Gene MAP3K3 (Mouse)

MAP3K3

Species: Mouse
Alias: MAP3K3, Map3k3
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: STE
Family: STE11
Subfamily: MEKK2

Sequence

Name Sequence Type Origin Length Description Download
MAP3K3.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 261 Kinase domain by global Sugen HMM Fasta, JSON
MAP3K3.NA RNA Sugen 3161 None Fasta, JSON
MAP3K3.AA Protein Sugen 626 None Fasta, JSON

Protein domain

Protein domains of MAP3K3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PB1 MAP3K3.AA PB1 44-123 21 2.1e-21 78.37 SMART 1-95 (95) Show / Hide 
Range on Protein: 44-123
Range on HMM: 1-95/95
Sequence Identity: 21% (20 aa)

DVRIKFEH-NGERRIIAFSRPVRYEDVEHKVTTVFGQ----PLDLHYM--NNEL--SILLKNQDDLDKAIDILDR------SSSMKSLRILLLSQ
.|..|. . .|. |.....|.....|. .||. ..|.    | .|.|   ....   .......||.......|.      ||..|.||...   
PVDVKCRYVGGDTRRFSVPRDWSFDDLMSKVAQRCGHDNDQPFTLKYQLPDEDGDAWVTITCDEDLQEMMEMYDSLESQNKSSCWKTLRLHVFPF
PB1 MAP3K3.AA PB1 44-123 24 2.4e-20 74.85 Pfam 1-86 (86) Show / Hide 
Range on Protein: 44-123
Range on HMM: 1-86/86
Sequence Identity: 24% (21 aa)

DVRIKFEHNGERRI--IAFSRPVRYEDVEHKVTTVFGQ--PLDLHYMNNEL--SILLKNQDDLDKAIDILDRS-SSMKSLRILLLSQ
.||||... |..|.  | ..|....||. |||. ....  .....| ....   .......||...... ..| .|| .||...  .
TVRIKCRYGGDIRRFIIHVRRNISFEDLMHKVEQRCKCDHTFKYQYPDEDGDDWVTITCDEDLQEMMEEYRSSEKSM-TLRLHVFPS
Kinase MAP3K3.AA MEKK2 362-622 88 8e-217 726.6 In-house 1-262 (262) Show / Hide 
Range on Protein: 362-622
Range on HMM: 1-262/262
Sequence Identity: 88% (231 aa)

WRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKILTIFMEYMPGGSVKDQLKAYGAL
||||||||||||||||.|||||||||||.||||||||.|||.|||.||||||||||||||||||||||||||..||.|.|||||||||||||||||||||
WRRGKLLGQGAFGRVYVCYDVDTGRELAVKQVQFDPDNPETRKEVQALECEIQLLKNLQHERIVQYYGCLRDNQEKTLSIFMEYMPGGSVKDQLKAYGAL

TESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGIRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEML
||.|||||||||||||.|||..||||||||||||||||.|||||||||||||||||||..||..||||||||||||||.||||||||||||.||||||||
TETVTRKYTRQILEGMHYLHDHMIVHRDIKGANILRDSSGNVKLGDFGASKRLQTICMHITGMKSVTGTPYWMSPEVINGEGYGRKADVWSIGCTVVEML

TEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFLRRIFVEARQ-RPSAEELLTHHFA
||||||||||||||||||||||||||||.|.|.|.||||.|.|||..| ||||||||.|||.
TEKPPWAEYEAMAAIFKIATQPTNPQLPQHVSQHARDFLKRCFVEIKQDRPSAEELLRHHFV
Kinase MAP3K3.AA STE11 362-622 47 1.4e-165 556.33 In-house 1-303 (303) Show / Hide 
Range on Protein: 362-622
Range on HMM: 1-303/303
Sequence Identity: 47% (143 aa)

WRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDS---PETSKEVSA------LECEIQLLKNLQHERIVQYYG-CLRDRAEKILTIFMEYMPGGSV
|..|...|.||||.||.|..||||...| ||.......   ....||...      ...||.|.|.|.|..||.||| ||.|.... . |||||.||||.
WQKGEIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFMEYCPGGSL

KDQLK-AYGA--LTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGN-VKLGDFGASKRLQTICMSGTG-------IRSVTGTPY--------
.. |.  .|.  ..|.|.||||.|||||..||||..|.||||||||||.|| || .||.|||..|||..||.....       ..|.|||||        
SSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPM

WMSPEVISGEG---YGRKADVWSLGCTVVEMLTEKPPWAEYEA--MAAIFKIATQ-PTNPQLPSHIS------EHGRDFLRRIFVEARQ-RPSAEELLTH
||.||||..||   ||||||.|||||||.||.| ||||..|..  |||.|||...  . |..|.|.|      |..|||||. |.   . ||.| .|| |
WMAPEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLLQH

HFA
.| 
PFI
Kinase MAP3K3.AA STE11-Unclassified 362-622 41 1.5e-111 376.87 In-house 1-308 (308) Show / Hide 
Range on Protein: 362-622
Range on HMM: 1-308/308
Sequence Identity: 41% (127 aa)

WRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDS---PETSKE-VSALECEIQLLKNLQHERIVQYYGCLRDRAEKILTIFMEYMPGGSVKDQLKA
|  |...|.|.||.||.| ...||  .| ||.    ..   ..  || . ... |...||.| |. |||||||  ...|... ||||||||||.   |. 
WQKGEFIGKGSFGQVYKCMNCNTGEFMAVKQIEIHDYNSQQEDMQKEMIQSIQKEMKVLKQLNHKNIVQYYGCEIHKHEDCINIFMEYMPGGSIWSMLNK

YGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQ------------------TICMSG----TGIRSVTGTPY---
||.. |.|..|||.||||| .||||. |.|||||||||| |. |..|| |||..|                     .|| .         |  ||||   
YGCFDEMVIKKYTKQILEGLAYLHSHGIIHRDIKGANILIDFDGICKLTDFGCAKQIEFDRTRTVRMNKIQNFDHYKICQHINSQQNHCKSMQGTPYQPF

WMSPEVIS---GEGYGRKADVWSLGCTVVEMLTEKPPWAEYEA---MAAIFKIATQPTNPQLPSHIS-----------EHGRDFLRRIF-VEARQRPSAE
||.||||.    .|..||.|.|||||||.|| | |.||. ...   |.||.||.   . ||.|.| |           . ..||||. | .    ||.| 
WMAPEVIKNSTQTGHCRKSDIWSLGCTVIEMATGKHPWSNCQNDNFMWAIMKIVMSNQIPQIPEHLSPVCDFISCWISQECKDFLRKCFQIDPKKRPTAN

ELLTHHFA
.|| | | 
QLLQHPFI
Kinase MAP3K3.AA STE 362-622 30 3.8e-104 352.29 In-house 1-359 (359) Show / Hide 
Range on Protein: 362-622
Range on HMM: 1-359/359
Sequence Identity: 30% (110 aa)

WRRGKLLGQGAFGRVYLCYDVD---------------TGRELASKQVQFDPDSPETSK-------------EVSALECEIQLLKNLQ--HERIVQYYGCL
|.. . .|.|||| ||......               ||.  | ||. .......  .             |.  .. ||...|...  |. ||.|||| 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

R-----DRAEKILTIFMEYMPGGSVKDQLK-AYGALT-------------ESVTRKYTRQILEG-MSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGAS
      . ..  | |.||||.|||. | .|  || .              ||. ....||||.| ..||||. |.|||||.||||      ||| ||| .
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVC

KRLQTICM------------SGTGIR-SVTGTPYWMSPEVISG------EGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQ----------
..|. ..             .. . | ...||| ||.||||..       ||..|.|.||||||..||.| ||||...  | |.| |..           
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL

----PTNPQLPSHIS-------------------EHGRDFLRRIFVEARQ-RPSAEELLT--HHFA
    .. |.||.|.|                   .. .||... ..   . ||.|..||   | | 
CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase MAP3K3.AA S_TKc 362-622 31 2.6e-97 330.51 SMART 1-231 (231) Show / Hide 
Range on Protein: 362-622
Range on HMM: 1-231/231
Sequence Identity: 31% (88 aa)

WRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKILTIFMEYMPG--GSVKDQLKAYG
.. ....|.||||.||.|....|||. | |..               .. |||.||. .|. ||..|.. .|   . | ..|||..|  |...| .| .|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRG

A------LTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGIRSVTGTPYWMSPEVISGEGYGR-KADVWS
       ..| ..|.|..||.... |.||. |.|||.| .||| |.  ..|..||| ...|          ... |||..|.|||.   |||. |.|.||
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWS

LGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFLRRIFV-EARQRPSAEELLT-------HHFA
.||.. |||. .||.     |...||.             |. ..||.|.... . ..||.| |.|.       | . 
CGCILYEMLCGYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MAP3K3.AA MEKK15 362-622 45 1.1e-95 324.16 In-house 1-264 (264) Show / Hide 
Range on Protein: 362-622
Range on HMM: 1-264/264
Sequence Identity: 45% (123 aa)

WRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDP-DSPETSKEVSALECEIQLLKNLQHERIVQYYG-CLRDRAEKILTIFMEYMPGGSVKDQLKAYG
|..|..||.||.| || |   .||  .| |||. |  |  .. ..   |  |..||| |.|  || | | ||    . .. |||...||||.   .  .|
WKKGNILGKGAYGTVY-CGLTNTGQLIAVKQVELDEIDKEKAKQQYRKLQEEVDLLKTLKHKNIVAYLGVCLE---DNVVNIFMQFVPGGSISSIINRFG

ALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTG---IRSVTGTPYWMSPEVISGEGYGRKADVWSLGCT
.| | |  |||.|||.|. ||| | .|||||||.|..  . | .|| |||  |||    ...|    ..|. |||||| ||||   |||||.|.||.|||
PLDEMVFCKYTKQILQGVQYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCAKRLCWQGINRTHSDMLKSMRGTPYWMAPEVIMETGYGRKSDIWSIGCT

VVEMLTEKPPWAEYEAMAAIFKIATQ-PTNPQLPSHISEHGRDFLRRIFV-EARQRPSAEELLTHHFA
| || | |||||. . |||.| | ..    |||| . ||  |.| |     .   ||.| .|| | | 
VFEMATRKPPWADMDRMAAMFYIGAHRDPMPQLPVKFSEDARMFVRMCLTRDQHERPTASQLLKHPFI
Kinase MAP3K3.AA Pkinase 362-622 30 4e-78 270.66 Pfam 1-293 (293) Show / Hide 
Range on Protein: 362-622
Range on HMM: 1-293/293
Sequence Identity: 30% (91 aa)

WRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKILTIFMEYMPGG----SVKDQLK-
...|. .|.|.||.||.|....||.. | |..  . ....  ..   |  |||..|.|.|. ||..|.. .|  .. . . |||..||    . .| .. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-SEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST

-AYGAL--TESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNV----KLGDFGASKRLQTICMSGTGIRSVTGTPYWMSPEVIS-GEGYGRKA
 ..|..  .| . ..| .|||.|. |.||. |.|||.| .||| |. |..    |..||| .| ..    ...   ...|||..|.||||  |..||.|.
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DVWSLGCTVVEMLTEKPPWAEY------EAMAAIFKIATQPTNPQLPSHIS-------------------EHGRDFLRRIF-VEARQRPSAEELLTHHFA
|.||.||.. |||. .||. .       . |. |..|   |.  . |  .|                   | ..||..... .   .||.||..| | . 
DMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase MAP3K3.AA ASK 367-622 41 6.2e-72 238.51 In-house 1-254 (254) Show / Hide 
Range on Protein: 367-622
Range on HMM: 1-254/254
Sequence Identity: 41% (110 aa)

LLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKILTIFMEYMPGGSVKDQLKA-YGALT--E
 ||.|..| ||   | .| . .| | ..        |..|  |  ||.| |.|.|. |||| ||  .  .. . |||| .||||. . |.. .| .   |
VLGKGTYGIVYAGRDMHTQVRIAIKEIPE-----RDSRYVQPLHEEIALHKQLRHRNIVQYLGC--CSENGYFKIFMEQVPGGSLSALLRSKWGPMKDNE

SVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDS-AGNVKLGDFGASKRLQTICMSGTGIRSVTGTPYWMSPEVI--SGEGYGRKADVWSLGCTVVEM
.  . ||.|||||..||| | |||||||| |.|    .| ||. ||| .|||  |        . |||  .| ||||     |||. ||.||.|||.|||
NTMNFYTKQILEGLKYLHENQIVHRDIKGDNVLVNTYSGVVKISDFGTCKRLAGINPC---TETFTGTLQYMAPEVIDQGQRGYGKPADIWSFGCTMVEM

LTEKPPWAEY-EAMAAIFKIATQPTNPQLPSHISEHGRDFLRRIF-VEARQRPSAEELLTHHFA
 | |||. |  |. ||.||.    . |..|. .|.. ..|..| | .....|.||..||   | 
ATGKPPFHELGEPQAAMFKVGMYKKHPEIPEELSAECKNFILRCFEPDPCKRASAQDLLQDPFL
Kinase MAP3K3.AA STE20 362-622 33 3e-68 233.04 In-house 1-288 (288) Show / Hide 
Range on Protein: 362-622
Range on HMM: 1-288/288
Sequence Identity: 33% (98 aa)

WRRGKLLGQGAFGRVYLCYDVDTGRE----LASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAE--KILTIFMEYMPGGSVKDQL
.   . .|||..| ||..|...||..     | |..  .....|  .|.  .. ||. .|...|. ||.|||.     .    | | |||. |||. | .
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQ-DEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIM

K---AYG------ALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGI-----RSVTGTPYWMSPEVISG
|     |       ..|.     .|..|.| .||||| |.|||||..||| .. |.||| ||| .  |..     .        .. ||||||.||||..
KHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHG-R-D-TMQFKRNTFVGTPYWMAPEVIQC

-----EGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIA--TQPTNPQL---PSHISEHGRDFLRRIFV-EARQRPSAEELLTHHFA
      ||. |.|.|||| |  ||.. .|| ... .| |.|.|.  . |. .     |.. | . .||. .  . .  .||.|..||.| | 
MEGPDKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase MAP3K3.AA MEKK4 362-622 37 1.9e-66 226.8 In-house 1-271 (271) Show / Hide 
Range on Protein: 362-622
Range on HMM: 1-271/271
Sequence Identity: 37% (103 aa)

WRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKILTIFMEYMPGGSVKDQLKAYGAL
| ||   |.| || || | ..||.. .| | . | ..   . |..     ||  .  . |.  | |||    | |  . |||||   |  .   .  | .
WQRGDHIGEGQFGKVYTCMNMDTHEVMAMKEMRFQRNDHKAIKNIAD---EIKIFEGIKHPNLVRYYGVEVHREE--MYIFMEYCSQGTLERVCHLGGNM

TESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTIC--MSGTGIRSVTGTPYWMSPEVIS---GE-------GYGRKAD
 | ..|.|| |.| ...|||.  |||||||.|||  |. . .|||||| | .||     | |  . |  ||. .| |||..   ..       |.|| ||
QEHMIRQYTKQLLRAVNYLHQHGIVHRDIKPANIFLDKCTVLKLGDFGCSVKLQNHSQTMPGE-FQSTMGTAAYMAPEVYTYTEKDETTGSYSGHGRAAD

VWSLGCTVVEMLTEKPPWA---EYEAMAAIFKIATQPTNPQLPSHISEHGRDFLRRIF-VEARQRPSAEELLTHHFA
.|||||.|||| | | ||.   .|.   .|      .. |. |   |  |.||.   .     .|. | ||| | |.
IWSLGCVVVEMMTGKRPWHGQTQYDHNFQIMYKVGMGHYPHIPDKMSPEGKDFFDHCLEHDPKDRWTANELLDHTFC
Kinase MAP3K3.AA CAMK 367-622 20 7.7e-64 204.31 In-house 1-425 (425) Show / Hide 
Range on Protein: 367-622
Range on HMM: 1-425/425
Sequence Identity: 20% (87 aa)

LLGQGAFGRVYLCYDVDTG------------RELASKQVQFD--PDSPE---------------------TSKEVSALECEIQLLKNLQ-------HERI
 ||.|.|| |.||..  |.            .. | | .  .  .|.                       . |    .. ||...|.||       |. |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQYYGCLRDRA-----------------EKILTIFM---EYMPGG----SVKDQLKAY---------------GALTESVTRKYTRQILEGMSYLHSNMI
.. |    |.                  .| . ..|   ||..||     . | ...                | .||. .|.| |||.... |.||. |
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDIKGANILRDSA-----------------GNVKLGDFGASKRLQTICMS--------------------GTGIRSVTGTPYWMS-PEVISG------
||||.|  ||| |.                  .|.|. ||| .....    .                    |   . . |||. |. |||..|      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------EGYGRKADVWSLGCTVVEMLTEKPPWAE----------------YEAMAAIFKIATQPTNPQLPS-------------------HISEHGRD
        ..||.|.|.||.|.    ||. .||. .                || .  | |   .   |...                    ..|.  .|
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

FLRRIFV-EARQRPSAEELLTHHFA
..|.. . .  .|...|. | | . 
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase MAP3K3.AA MEKK1 362-621 38 1.8e-60 207.24 In-house 1-266 (266) Show / Hide 
Range on Protein: 362-621
Range on HMM: 1-266/266
Sequence Identity: 38% (102 aa)

WRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQF-DPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKILTIFMEYMPGGSVKDQLKAYGA
| .|  .| |||   |   || ||  .| ||. .    | .    . ..  ||...  . |  |.   |   . .     .| | ||||||   || |||
WTKGQQIGTGAFSSCYMAQDVKTGTLMAVKQITYCRNNSSDQEDVMEEIRKEIRMMAHFNHPHIIRMMGATCHDSH--YNVFIEWMPGGSVAHLLKDYGA

LTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGN-VKLGDFGASKRLQT-ICMSGTGIRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVV
  .||. .|. |.. |.|||| | |.|||.|||| | || |      |||.  |.   |   .       ||   | |||  |. |||  |.|| || ..
FKNSVVINYIHQVCRGLSYLHDNQIIHRDVKGANLLMDSTGHHLRIADFGTAARMNSDITRTDEFQGQFLGTIAFMAPEVLRGQQYGRSCDIWSVGCCII

EMLTEKPPWAEYEA---MAAIFKIATQPTNPQLPSHISEHGRDF-LRRIFVEARQRPSAEELLTH-HF
|| . ||||        .. |||||   | |  |.| |   ||  ||   ..   ||   ||| |  |
EMCCTKPPWNNEKHSNHYQLIFKIASANTPPPIPEHLSPGLRDITLRCLEAQPQDRPPVMELLKHPVF
Kinase MAP3K3.AA Pkinase_Tyr 362-509 32 5.9e-25 85.15 Pfam 1-156 (270) Show / Hide 
Range on Protein: 362-509
Range on HMM: 1-156/270
Sequence Identity: 32% (52 aa)

WRRGKLLGQGAFGRVYLCYDV----DTGRELASKQVQFDPDSPETSKE---VSALECEIQLLKNL-QHERIVQYYGCLRDRAEK-ILTIFMEYMPGGSVK
 . || ||.||||.||...      .|. . | | .      . ...|     ..  |....|.| .|. ||..||.  |. |   . | |||||.|. .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK-----EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLL

DQLKAY----GALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFG
| |..     ..|| .   .. .|| .||.||.|. ..|||.   |.| .. . || .|||
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFG
Kinase MAP3K3.AA TyrKc 362-621 25 1.1e-17 62.95 SMART 1-280 (280) Show / Hide 
Range on Protein: 362-621
Range on HMM: 1-280/280
Sequence Identity: 25% (75 aa)

WRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNL--QHERIVQYYGCLRDRAE-----KILTIFMEYMPGGSVKDQ
 . || || ||||.||..      .. | | .. |         . ..  |......|  .|. ||. ||. ..  .     . | | |||||.|. || 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LKAYGA-LTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRL----------QTICMSG--TGI--RSVTGTPYWMSPEVI
|....  |. .   ..  || .||.||||. ..|||.   |.| .. . || .||| |. .          ... ...   |     .     ||.||.|
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI----RWMAPECI

SGEGYGRKADVWSLGCTVVEMLTE-KPPWAE-----YEAMAAIFKIATQPTNPQLPS-------HISEHGRDFLRRIFVE-ARQRPSAEELLTHHF
    .  | |||| | .  |..|  ..|. .      ..  .| .. .    || |.       . ..   .  ..   | . .||. .|.  . |
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase MAP3K3.AA Pkinase_Tyr 533-569 35 0.000181 15.76 Pfam 180-218 (270) Show / Hide 
Range on Protein: 533-569
Range on HMM: 180-218/270
Sequence Identity: 35% (14 aa)

WMSPEVISGEGYGRKADVWSLGCTVVEMLT-EKPP-WAE
||.||.|.   .  | |||| | .  |..|  . | ...
WMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPG