C. elegans Protein Kinases


# Sequence Super-family Group Family Mammalian orthologue Mammalian homologue Specificity Worm name SH3 SH2 TMD FNIII Comment SP# Chrom BEGIN END STRAND
1 C12D8.10a Protein Kinase AGC AKT RACa_h (504aa 55%)     AKT-1 - - - - PH & STK domains NRP:AF072379 5 10,198,008 10,201,503 +
2 F28H6.1 Protein Kinase AGC AKT   RACa_h (500aa 53%)   AKT-2 - - - - R03E1, PH & STK domains NRP:AF072381 X 13,893,198 13,897,051 +
3 H42K12.1 Protein Kinase AGC AKT PDK1_h (312aa 40%)     PDK-1a, H33H01.A, H42K12 - - - -     X 1,046,511 1,048,303 +
4 W04B5.5 Protein Kinase AGC AKT PDK1_h (301aa 41%)       - - - -     3 1,966,640 1,973,586 -
5 C10H11.9 Protein Kinase AGC DMPK KIAA0619_h (1369aa 33%)     LET-502 - - - -   NRP:U85515 1 4,061,871 4,067,177 -
6 K08B12.5 Protein Kinase AGC DMPK MRCK_r (1611aa 37%)       - - - -     5 6,207,737 6,216,897 -
7 F19C6.1 Protein Kinase AGC GRK GRK6_h (598aa 55%)     YQR1_CAEEL - - - -   SP:Q09537 X 9,745,518 9,752,555 -
8 W02B3.2 Protein Kinase AGC GRK BARK1_h (690aa 64%)     YR22_CAEEL - - - -   SP:Q09639 3 658,822 662,740 +
9 M03C11.1 Protein Kinase AGC M03C11.1   PKACa_h (311aa 32%);     - - - -     3 9,833,854 9,836,450 -
10 C10C6.1 Protein Kinase AGC MAST MAST205_m (1311aa 37%)     KIN-4 - - - -     4 11,032,619 11,039,833 +
11 R166.5 Protein Kinase AGC MNK MNK1_h (404aa 44%)       - - - -     2 10,535,818 10,540,157 -
12 R11G1.4 Protein Kinase AGC NDR NDR_h (444aa 66%)       - - - -     X 3,392,039 3,404,894 -
13 T20F10.1 Protein Kinase AGC NDR LATS1_h (502aa 48%)       - - - -     1 9,624,284 9,629,991 -
14 F47F2.1 Protein Kinase AGC PKA PKX1_h (321aa 50%)       - - - -     X 3,643,260 3,647,813 +
15 ZK909.2a Protein Kinase AGC PKA PKACa_h (346aa 82%)     KAPC_CAEEL; PKAC; KIN-1; Cecatalpha - - - -   SP:P21137 2 11,883,078 11,890,034 -
16 B0545.1a Protein Kinase AGC PKC PKCd_h (672aa 48%)     KPC1_CAEEL; tpa-1; tpa-1a; tpa-1b; tpa-1c - - - -   SP:P34722 4 89,869 107,968 +
17 E01H11.1 Protein Kinase AGC PKC PKCa_h (659aa 68%)     PKC-2; KIN-11; PKC2; PKC2A; PKC2Bff09e5 - - - -     X 9,117,541 9,124,398 +
18 F09E5.1 Protein Kinase AGC PKC PKCi_h (587aa 58%)     PKC-3; Protein kinase c3 - - - -   SP:AF025666 2 5,369,258 5,372,862 +
19 F46F6.2 Protein Kinase AGC PKC PRK2_h (006aa 38%)       - - - -     X 10,150,898 10,155,431 +
20 F47D12 Protein Kinase AGC PKC   PRK2_h (281a 29%)     - - - -     3 5,780,725 5,780,747  
21 F57F5.5 Protein Kinase AGC PKC PKCe_h (577aa 63%)     KPC2_CAEEL; PKC1 - - - -   SP:P34885 5 11,964,514 11,968,418 -
22 T25E12.4a Protein Kinase AGC PKC EPK2_h (856aa 51%)       - - - - Y70C5D   5 16,671,801 16,712,306 +
23 W09C5.5 Protein Kinase AGC PKC PKCm_h (828aa 38%)       - - - -     1 12,800,097 12,808,059 -
24 C09G4.2 Protein Kinase AGC PKG   CGK_h (585aa 43%)     - - - -     4 8,138,178 8,152,759 +
25 F55A8.2a Protein Kinase AGC PKG CGK_h (714aa 49%)       - - - -     4 1,817,341 1,849,210 +
x C54G4.1N Protein Kinase AGC S6K MSK2_h (749aa 47%)       - - - - cat#2   1 7,347,216 7,348,711  
26 R04A9.5 Protein Kinase AGC S6K   p70S6K_h (313aa 51%)     - - - -     X 109,425 119,440 -
x T01H8.1aN Protein Kinase AGC S6K RSK2_h (698aa 62%)       - - - - cat#2   1 7,908,936 7,909,756  
27 Y47D3A.r Protein Kinase AGC S6K p70S6K_h (416aa 60%)       - - - -     3 10,685,797 10,691,671 +
28 W10G6.2 Protein Kinase AGC SGK SGK_h (383aa 52%)       - - - -     X 15,962,854 15,967,119 -
29 F28C10.3 Protein Kinase AGC Unique   RSK2_h (273aa 36%)     - - - -     X 257,053 260,650 -
30 F31E3.2 Protein Kinase AGC Unique   PKCi_h (330aa 29%)     - - - -     3 6,432,888 6,436,022 +
31 F42A10.4 Protein kinase Atypical MHCK EEF2-K_h     EEF-2 kinase - - - - Myosin heavy chain kinase, Elongation factor II kinase          
32 C38C3.5B Protein kinase Atypical A6       unc-60B/(unc-66)/ADF2/C38C3.5B/F53E2.C Actin binding protein that regulates the polymerization of actin; similar to mammalian cofilin and destrin - - - -            
33 F38E9.5 Protein kinase Atypical A6         - - - -            
34 ZK370.5 Protein kinase Atypical PDK       PDK_ce PYRUVATE DEHYDROGENASE KINASE - - - -            
35 F15A2.6 Protein Kinase CAMK AMPK AJ006701_h (657aa 48%)       - - - -     X 13,233,578 13,240,322 -
36 PAR2.3 Protein Kinase CAMK AMPK AMPK_h (552aa 44%)     YNA3_CAEEL - - - -   SP:P45894 3 8,197,486 8,201,298 -
37 T01C8.1 Protein Kinase CAMK AMPK AMPKa2_h (569aa 57%)       - - - -     X 16,507,594 16,510,694 +
38 W03G1.6 Protein Kinase CAMK AMPK KIAA0175_h (728aa 37%)       - - - -     4 464,100 476,498 -
39 F17E5.1a Protein Kinase CAMK CAMK CASK_h (976aa 47%)     LIN2_CAEEL; LIN-2 X - - -   SP:P54936 X 12,145,480 12,159,517 -
40 F32D8.1 Protein Kinase CAMK CAMK   KIAA0369_h (279aa 36%)     - - - -     5 10,830,989 10,832,370 +
41 K07A9.2 Protein Kinase CAMK CAMK CAMKI_h (264aa 66%)       - - - -     4 1,801,075 1,802,869 +
42 K11E8.1a Protein Kinase CAMK CAMK CAMKIIb_m (542aa 61%)     Unc-43 - - - -     4 9,916,027 9,930,661 -
43 R06A10.4 Protein Kinase CAMK CAMK PSK-H1_h (258aa 47%)       - - - -     1 978,214 983,939 -
44 Y75B8A.a Protein Kinase CAMK CAMK   KIAA0369_h (143aa 46%) partial     - - - - merge with Y79H2A.g   3 11,386,397 11,388,911 +
45 T08D2.7 Protein Kinase CAMK CHK2         - - - - was T08C2.e - T08D2.7 is truncated, FHA domain   5 20,269,698 20,270,271  
46 Y116F11.zz34 Protein Kinase CAMK CHK2   CHK2_h (271aa 28%)     - - - - reconstructed   5 20,083,784 20,085,680 -
47 Y60A3.b Protein Kinase CAMK CHK2 CHK2_h (373aa 32%)       - - - -     5 20,125,739 20,133,900 -
48 K12C11.4 Protein Kinase CAMK DAPK DAPK_h (1424aa 33%)       - - - -     1 1,159,485 1,182,054 -
49 B0496.3 Protein Kinase CAMK EMK KIAA0537_h (460aa 43%)     TAK - - - -     4 7,066,519 7,079,531 +
50 B0511.4 Protein Kinase CAMK EMK   TSSK-2_m (260aa 41%)     - - - -     1 9,956,598 9,957,886 +
51 C27D6 Protein Kinase CAMK EMK         - - - -     2 5,149,989 5,149,311  
52 F23C8.8 Protein Kinase CAMK EMK   149aa KIN1_sp 39%     - - - -     1 1,763,916 1,763,987  
53 F49C5.4 Protein Kinase CAMK EMK EMK1_h (255aa 47%)       - - - -     2 12,506,659 12,508,248 +
54 F53B3 Protein Kinase CAMK EMK         - - - -     X 2,599,490 2,600,954  
55 H39E23.1 Protein Kinase CAMK EMK C-TAK1_h (1018aa 45%)     PAR-1 - - - -     5 14,062,096 14,075,694 -
56 Y38H8A.4 Protein Kinase CAMK EMK TSSK-2_m (289aa 38%)       - - - -     4 13,179,516 13,181,125 -
57 ZK524.4 Protein Kinase CAMK EMK SNRK_r (513aa 51%) C-TAK1_h (637aa 37%)     - - - -     4 10,499,182 10,500,269 -
58 C44C8.6 Protein Kinase CAMK MAPKAP MAPKAP3_h (335aa 59%)       - - - -     4 865,637 870,622 -
59 K08F8.1 Protein Kinase CAMK MAPKAP   MAPKAP3_h (375aa 42%)     - - - -     2 8,735,603 8,738,544 +
60 C24G7.5C Protein Kinase CAMK MLCK   MLCK_h (752aa 28%)     - - - X PK 43-195, IG 859-919, FN 938-1027, PK 1102-1352   1 3,446,469 3,447,323  
x C24G7.5N Protein Kinase CAMK MLCK         - - - - cat#1   1 3,439,213 3,439,769  
61 F12F3.2 Protein Kinase CAMK MLCK   Titin_h (2291aa 24%)     - - - X 2877aa w FN and IG domains; TMD=2849-2873 (C-terminal)   5 6,064,366 6,075,845 -
62 ZC373.4 Protein Kinase CAMK MLCK MLCK_h (784aa 30%)       - - - -     X 9,816,290 9,823,287 -
63 ZK617.1a Protein Kinase CAMK MLCK Titin_h (3643aa 27%)     PJK4; twitchin; unc-22 - - - X >6000aa w FN and IG domains, no TMD NRP:1942207 2 5,283,184 5,284,824 +
64 Y50D7.Con462 Protein Kinase CAMK PhK PhKg_m (356aa 45%)       - - - -            
65 C54G4.1C Protein Kinase CAMK S6K   MSK1_h (753aa 47%)     - - - - cat#1   1 7,349,312 7,351,052  
66 T01H8.1aC Protein Kinase CAMK S6K   RSK3_h (694aa 63%)     - - - - cat#1   1 7,907,871 7,908,220  
67 C28A5.6 Protein Kinase CKI C28A5.6     Worm   - - - - Unique C-terminal motif   3 3,861,013 3,866,717 -
68 K09C6.1 Protein Kinase CKI C28A5.6     Worm   - - - - Unique C-terminal motif   5 907,587 910,896 +
69 C44C10.7 Protein Kinase CKI C44C10.7     Worm   - - - -     X 11,440,516 11,441,785 -
70 F16B12.7 Protein Kinase CKI C44C10.7     Worm   - - - -     X 13,854,036 13,855,205 +
71 K08H2.5 Protein Kinase CKI C44C10.7     Worm   - - - -     X 12,986,600 12,987,769 -
72 B0207.7 Protein Kinase CKI CKI     Worm   - - - -     1 5,276,610 5,278,195 -
73 B0218.5 Protein Kinase CKI CKI     Worm   - - - -     4 7,770,273 7,771,466 -
74 C03C10.1 Protein Kinase CKI CKI CKIa_h (315aa 86%) CKIg2_h (289aa 52%)   YKL1_CAEEL - - - -   SP:P42168 3 3,522,011 3,523,709 -
75 C03C10.2 Protein Kinase CKI CKI   CKId_h (221aa 31%)   YKL2_CAEEL - - - -   SP:P42169 3 3,528,061 3,530,500 +
76 C04G2.2 Protein Kinase CKI CKI     Worm   - - - -     4 9,681,766 9,683,367 +
77 C05C12.1 Protein Kinase CKI CKI     Worm   - - - -     4 10,847,185 10,848,891 +
78 C08F8.6 Protein Kinase CKI CKI     Worm   - - - -     4 10,755,975 10,757,477 -
79 C09B9.4 Protein Kinase CKI CKI     Worm   - - - -     4 4,950,539 4,952,210 -
80 C09D4.3 Protein Kinase CKI CKI     Worm   - - - -     1 4,810,707 4,813,333 +
81 C14A4.13 Protein Kinase CKI CKI     Worm   - - - -     2 10,609,933 10,611,925 +
82 C17C3.11 Protein Kinase CKI CKI     Worm   - - - -     2 5,527,065 5,528,256 +
83 C25H3.1 Protein Kinase CKI CKI     Worm   - - - - extended based on U64854 homology   2 5,689,395 5,690,125 +
84 C27D8.1 Protein Kinase CKI CKI     Worm   - - - -     4 12,514,248 12,515,665 +
85