CLUSTAL W (1.8) multiple sequence alignment DMPK_GEK_MRCKb -----------------------------FEIIK-----VIGRGAFG-----EVAVVKMK DMPK_GEK_MRCKa -----------------------------FEILK-----VIGRGAFG-----EVAVVKLK DMPK_GEK_DMPK2 -----------------------------FEILK-----VIGRGAFG-----EVTVVRQR DMPK_GEK_DMPK1 -----------------------------FEILK-----VIGRGAFS-----EVAVVKMK DMPK_ROCK_ROCK2 -----------------------------YDVVK-----VIGRGAFG-----EVQLVRHK DMPK_ROCK_ROCK1 -----------------------------YEVVK-----VIGRGAFG-----EVQLVRHK DMPK__CRIK -----------------------------FEVRS-----LVGCGHFA-----EVQVVREK NDR__NDR1 -----------------------------FESLK-----VIGRGAFG-----EVRLVQKK NDR__NDR2 -----------------------------FESLK-----VIGRGAFG-----EVRLVQKK NDR__LATS1 -----------------------------FVKIK-----TLGIGAFG-----EVCLARKV NDR__LATS2 -----------------------------FVKIK-----TLGIGAFG-----EVCLACKV MAST__MAST1 -----------------------------FDTIK-----LISNGAYG-----AVYLVRHR MAST__MAST4 -----------------------------FETIK-----LISNGAYG-----AVYFVRHK MAST__MAST2 -----------------------------FETIK-----LISNGAYG-----AVFLVRHK MAST__MAST3 -----------------------------FETIK-----LISNGAYG-----AVYLVRHR AKT__AKT1 -----------------------------FEYLK-----LLGKGTFG-----KVILVKEK AKT__AKT2 -----------------------------FDYLK-----LLGKGTFG-----KVILVREK AKT__AKT3 -----------------------------FDYLK-----LLGKGTFG-----KVILVREK SGK__SGK -----------------------------FHFLK-----VIGKGSFG-----KVLLARHK SGK__SGK3 -----------------------------FDFLK-----VIGKGSFG-----KVLLAKRK SGK__SGK2 -----------------------------FDFLK-----VIGKGNYG-----KVLLAKRK PKC_Alpha_PKCa -----------------------------FNFLM-----VLGKGSFG-----KVMLADRK PKC_Alpha_PKCb -----------------------------FNFLM-----VLGKGSFG-----KVMLSERK PKC_Alpha_PKCg -----------------------------FSFLM-----VLGKGSFG-----KVMLAERR PKC_Eta_PKCh -----------------------------FEFIR-----VLGKGSFG-----KVMLARVK PKC_Eta_PKCe -----------------------------FNFIK-----VLGKGSFG-----KVMLAELK PKC_Delta_PKCd -----------------------------FIFHK-----VLGKGSFG-----KVLLGELK PKC_Delta_PKCt -----------------------------FILHK-----MLGKGSFG-----KVFLAEFK PKC_Iota_PKCi -----------------------------FDLLR-----VIGRGSYA-----KVLLVRLK PKC_Iota_PKCz -----------------------------FDLIR-----VIGRGSYA-----KVLLVRLK PKN__PKN1 -----------------------------FKFLA-----VLGRGHFG-----KVLLSEFR PKN__PKN2 -----------------------------FRCCA-----VLGRGHFG-----KVLLAEYK PKN__PKN3 -----------------------------FRCLA-----VLGRGHFG-----KVLLVQFK RSK_MSK_MSK1 -----------------------------FELLK-----VLGTGAYG-----KVFLVRKI RSK_MSK_MSK2 -----------------------------FELLK-----VLGTGAYG-----KVFLVRKA RSK_p70_p70S6K -----------------------------FELLR-----VLGKGGYG-----KVFQVRKV RSK_p70_p70S6Kb -----------------------------FELLR-----VLGKGGYG-----KVFQVRKV RSK_RSK_RSK1 -----------------------------FELLK-----VLGQGSYG-----KVFLVRKV RSK_RSK_RSK2 -----------------------------FELLK-----VLGQGSFG-----KVFLVKKI RSK_RSK_RSK3 -----------------------------FELLK-----VLGQGSFG-----KVFLVRKV RSK_RSK_RSK4 -----------------------------FELLK-----VLGQGSFG-----KVFLVRKK GRK_BARK_BARK1 -----------------------------FSVHR-----IIGRGGFG-----EVYGCRKA GRK_BARK_BARK2 -----------------------------FSVHR-----IIGRGGFG-----EVYGCRKA GRK_GRK_GPRK4 -----------------------------FRHYR-----VLGKGGFG-----EVCACQVR GRK_GRK_GPRK5 -----------------------------FRQYR-----VLGKGGFG-----EVCACQVR GRK_GRK_GPRK6 -----------------------------FRQYR-----VLGKGGFG-----EVCACQVR GRK_GRK_RHOK -----------------------------FLDFR-----VLGKGGFG-----EVSACQMK GRK_GRK_GPRK7 -----------------------------FTEFR-----VLGKGGFG-----EVCAVQVK PKA__PRKX -----------------------------FDTLA-----TVGTGTFG-----RVHLVKEK PKA__PRKY -----------------------------CDALV-----TMGTGTFG-----RVHLVKEK PKA__PKACa -----------------------------FERIK-----TLGTGSFG-----RVMLVKHK PKA__PKACb -----------------------------FERKK-----TLGTGSFG-----RVMLVKHK PKA__PKACg -----------------------------FERLR-----TLGMGSFG-----RVMLVRHQ PKG__PKG1 -----------------------------FNIID-----TLGVGGFG-----RVELVQLK PKG__PKG2 -----------------------------LEIIA-----TLGVGGFG-----RVELVKVK PKB__PDK1 -----------------------------FKFGK-----ILGEGSFS-----TVVLAREL YANK__YANK2 -----------------------------FQILR-----AIGKGSFG-----KVCIVQKR YANK__YANK1 -----------------------------FEILR-----AIGKGSFG-----KVCIVQKN YANK__YANK3 -----------------------------FQILR-----AIGKGSFG-----KVCIVQKR RSK__SgK494 -----------------------------LKILG-----LVAKGSFG-----TVLKVLDC RSKL__RSKL2 CRVVGVIEKVQLVQDPATGGTFVVKSLPRCHMVSRERLTIIPHGVPYMTKLLRYFVSEDS RSKL__RSKL1 -----------------------------CSPLS---------GAN------EYIASTDT MAST__MASTL -----------------------------FSIVK-----PISRGAFG-----KVYLGQKG * DMPK_GEK_MRCKb ------NT-----------------ERIYAMKILNKWE---------------------- DMPK_GEK_MRCKa ------NA-----------------DKVFAMKILNKWE---------------------- DMPK_GEK_DMPK2 ------DT-----------------GQIFAMKMLHKWE---------------------- DMPK_GEK_DMPK1 ------QT-----------------GQVYAMKIMNKWD---------------------- DMPK_ROCK_ROCK2 ------AS-----------------QKVYAMKLLSKFE---------------------- DMPK_ROCK_ROCK1 ------ST-----------------RKVYAMKLLSKFE---------------------- DMPK__CRIK ------AT-----------------GDIYAMKVMKKKA---------------------- NDR__NDR1 ------DT-----------------GHVYAMKILRKAD---------------------- NDR__NDR2 ------DT-----------------GHIYAMKILRKSD---------------------- NDR__LATS1 ------DT-----------------KALYATKTLRKKD---------------------- NDR__LATS2 ------DT-----------------HALYAMKTLRKKD---------------------- MAST__MAST1 ------DT-----------------RQRFAMKKINKQN---------------------- MAST__MAST4 ------ES-----------------RQRFAMKKINKQN---------------------- MAST__MAST2 ------ST-----------------RQRFAMKKINKQN---------------------- MAST__MAST3 ------DT-----------------RQRFAIKKINKQN---------------------- AKT__AKT1 ------AT-----------------GRYYAMKILKKEV---------------------- AKT__AKT2 ------AT-----------------GRYYAMKILRKEV---------------------- AKT__AKT3 ------AS-----------------GKYYAMKILKKEV---------------------- SGK__SGK ------AE-----------------EVFYAVKVLQKKA---------------------- SGK__SGK3 ------LD-----------------GKFYAVKVLQKKI---------------------- SGK__SGK2 ------SD-----------------GAFYAVKVLQKKS---------------------- PKC_Alpha_PKCa ------GT-----------------EELYAIKILKKDV---------------------- PKC_Alpha_PKCb ------GT-----------------DELYAVKILKKDV---------------------- PKC_Alpha_PKCg ------GS-----------------DELYAIKILKKDV---------------------- PKC_Eta_PKCh ------ET-----------------GDLYAVKVLKKDV---------------------- PKC_Eta_PKCe ------GK-----------------DEVYAVKVLKKDV---------------------- PKC_Delta_PKCd ------GR-----------------GEYFAIKALKKDV---------------------- PKC_Delta_PKCt ------KT-----------------NQFFAIKALKKDV---------------------- PKC_Iota_PKCi ------KT-----------------DRIYAMKVVKKEL---------------------- PKC_Iota_PKCz ------KN-----------------DQIYAMKVVKKEL---------------------- PKN__PKN1 ------PS-----------------GELFAIKALKKGD---------------------- PKN__PKN2 ------NT-----------------NEMFAIKALKKGD---------------------- PKN__PKN3 ------GT-----------------GKYYAIKALKKQE---------------------- RSK_MSK_MSK1 S---GHDT-----------------GKLYAMKVLKKAT---------------------- RSK_MSK_MSK2 G---GHDA-----------------GKLYAMKVLRKAA---------------------- RSK_p70_p70S6K T---GANT-----------------GKIFAMKVLKKAM---------------------- RSK_p70_p70S6Kb Q---GTNL-----------------GKIYAMKVLRKAK---------------------- RSK_RSK_RSK1 K---GSDA-----------------GQLYAMKVLKKAT---------------------- RSK_RSK_RSK2 S---GSDA-----------------RQLYAMKVLKKAT---------------------- RSK_RSK_RSK3 T---RPDS-----------------GHLYAMKVLKKAT---------------------- RSK_RSK_RSK4 T---GPDA-----------------GQLYAMKVLKKAS---------------------- GRK_BARK_BARK1 ------DT-----------------GKMYAMKCLDKKR---------------------- GRK_BARK_BARK2 ------DT-----------------GKMYAMKCLDKKR---------------------- GRK_GRK_GPRK4 ------AT-----------------GKMYACKKLQKKR---------------------- GRK_GRK_GPRK5 ------AT-----------------GKMYACKRLEKKR---------------------- GRK_GRK_GPRK6 ------AT-----------------GKMYACKKLEKKR---------------------- GRK_GRK_RHOK ------AT-----------------GKLYACKKLNKKR---------------------- GRK_GRK_GPRK7 ------NT-----------------GKMYACKKLDKKR---------------------- PKA__PRKX ------TA-----------------KHFFALKVMSIPD---------------------- PKA__PRKY ------TA-----------------KHFFALKVMSIPD---------------------- PKA__PKACa ------ET-----------------GNHYAMKILDKQK---------------------- PKA__PKACb ------AT-----------------EQYYAMKILDKQK---------------------- PKA__PKACg ------ET-----------------GGHYAMKILNKQK---------------------- PKG__PKG1 ------SEE----------------SKTFAMKILKKRH---------------------- PKG__PKG2 ------NE-----------------NVAFAMKCIRKKH---------------------- PKB__PDK1 ------AT-----------------SREYAIKILEKRH---------------------- YANK__YANK2 ------DT-----------------KKMYAMKYMNKQK---------------------- YANK__YANK1 ------DT-----------------KKMYAMKYMNKQK---------------------- YANK__YANK3 ------DT-----------------EKMYAMKYMNKQQ---------------------- RSK__SgK494 -------TQ----------------KAVFAVKVVPKVK---------------------- RSKL__RSKL2 IFLHLEHVQGGTLWSHLLSQAHSRHSGLSSGSTQERMKAQLNPHLNLLTPARLPSGHAPG RSKL__RSKL1 --LKTEEVL------------------LFTDQTDD------------------------- MAST__MASTL -------------------------GKLYAVKVVKKAD---------------------- : . DMPK_GEK_MRCKb ---------------MLK-RAETACFREERD------VLVNGDC------QWITALHYAF DMPK_GEK_MRCKa ---------------MLK-RAETACFREERD------VLVNGDN------KWITTLHYAF DMPK_GEK_DMPK2 ---------------MLK-RAETACFREERD------VLVKGDS------RWVTTLHYAF DMPK_GEK_DMPK1 ---------------MLK-RGEVSCFREERD------VLVNGDR------RWITQLHFAF DMPK_ROCK_ROCK2 ---------------MIK-RSDSAFFWEERD------IMAFANS------PWVVQLFYAF DMPK_ROCK_ROCK1 ---------------MIK-RSDSAFFWEERD------IMAFANS------PWVVQLFYAF DMPK__CRIK ---------------LLA-QEQVSFFEEERN------ILSRSTS------PWIPQLQYAF NDR__NDR1 ---------------MLE-KEQVGHIRAERD------ILVEADS------LWVVKMFYSF NDR__NDR2 ---------------MLE-KEQVAHIRAERD------ILVEADG------AWVVKMFYSF NDR__LATS1 ---------------VLL-RNQVAHVKAERD------ILAEADN------EWVVRLYYSF NDR__LATS2 ---------------VLN-RNQVAHVKAERD------ILAEADN------EWVVKLYYSF MAST__MAST1 ---------------LIL-RNQIQQAFVERD------ILTFAEN------PFVVGMFCSF MAST__MAST4 ---------------LIL-RNQIQQAFVERD------ILTFAEN------PFVVSMYCSF MAST__MAST2 ---------------LIL-RNQIQQAFVERD------ILTFAEN------PFVVSMFCSF MAST__MAST3 ---------------LIL-RNQIQQVFVERD------ILTFAEN------PFVVSMFCSF AKT__AKT1 ---------------IVA-KDEVAHTLTEN-------RVLQNSR-----HPFLTALKYSF AKT__AKT2 ---------------IIA-KDEVAHTVTES-------RVLQNTR-----HPFLTALKYAF AKT__AKT3 ---------------IIA-KDEVAHTLTES-------RVLKNTR-----HPFLTSLKYSF SGK__SGK ---------------ILK-KKEEKHIMSERN------VLLKNVK-----HPFLVGLHFSF SGK__SGK3 ---------------VLN-RKEQKHIMAERN------VLLKNVK-----HPFLVGLHYSF SGK__SGK2 ---------------ILK-KKEQSHIMAERS------VLLKNVR-----HPFLVGLRYSF PKC_Alpha_PKCa ---------------VIQ-DDDVECTMVEKR------VLALLDK-----PPFLTQLHSCF PKC_Alpha_PKCb ---------------VIQ-DDDVECTMVEKR------VLALPGK-----PPFLTQLHSCF PKC_Alpha_PKCg ---------------IVQ-DDDVDCTLVEKR------VLALGGRGPGGRPHFLTQLHSTF PKC_Eta_PKCh ---------------ILQ-DDDVECTMTEKR------ILSLARN-----HPFLTQLFCCF PKC_Eta_PKCe ---------------ILQ-DDDVDCTMTEKR------ILALARK-----HPYLTQLYCCF PKC_Delta_PKCd ---------------VLI-DDDVECTMVEKR------VLTLAAE-----NPFLTHLICTF PKC_Delta_PKCt ---------------VLM-DDDVECTMVEKR------VLSLAWE-----HPFLTHMFCTF PKC_Iota_PKCi ---------------VND-DEDIDWVQTEKH------VFEQASN-----HPFLVGLHSCF PKC_Iota_PKCz ---------------VHD-DEDIDWVQTEKH------VFEQASS-----NPFLVGLHSCF PKN__PKN1 ---------------IVA-RDEVESLMCEKR------ILAAVTSAG---HPFLVNLFGCF PKN__PKN2 ---------------IVA-RDEVDSLMCEKR------IFETVNSVR---HPFLVNLFACF PKN__PKN3 ---------------VLS-RDEIESLYCEKR------ILEAVGCTG---HPFLLSLLVCF RSK_MSK_MSK1 ---------------IVQKAKTTEHTRTERQ------VLEHIRQS-----PFLVTLHYAF RSK_MSK_MSK2 ---------------LVQRAKTQEHTRTERS------VLELVRQA-----PFLVTLHYAF RSK_p70_p70S6K ---------------IVRNAKDTAHTKAERN------ILEEVKH------PFIVDLIYAF RSK_p70_p70S6Kb ---------------IVRNAKDTAHTRAERN------ILESVKH------PFIVELAYAF RSK_RSK_RSK1 ---------------LK--VRDRVRSKMERD------ILAEVNH------PFIVKLHYAF RSK_RSK_RSK2 ---------------LK--VRDRVRTKMERD------ILVEVNH------PFIVKLHYAF RSK_RSK_RSK3 ---------------LK--VRDRVRTKMERD------ILADVNH------PFVVKLHYAF RSK_RSK_RSK4 ---------------LK--VRDRVRTKMERD------ILVEVNH------PFIVKLHYAF GRK_BARK_BARK1 ---------------IKM-KQGETLALNERI------MLSLVSTGD---CPFIVCMSYAF GRK_BARK_BARK2 ---------------IKM-KQGETLALNERI------MLSLVSTGD---CPFIVCMTYAF GRK_GRK_GPRK4 ---------------IKK-RKGEAMALNEKR------ILEKVQS------RFVVSLAYAY GRK_GRK_GPRK5 ---------------IKK-RKGESMALNEKQ------ILEKVNS------QFVVNLAYAY GRK_GRK_GPRK6 ---------------IKK-RKGEAMALNEKQ------ILEKVNS------RFVVSLAYAY GRK_GRK_RHOK ---------------LKK-RKGYQGAMVEKK------ILMKVHS------RFIVSLAYAF GRK_GRK_GPRK7 ---------------LKK-KGGEKMALLEKE------ILEKVSS------PFIVSLAYAF PKA__PRKX ---------------VIR-LKQEQHVHNEKS------VLKEVSH------PFLIRLFWTW PKA__PRKY ---------------VIR-RKQEQHVHNEKS------VLKEVSH------PFLIRLFWTW PKA__PKACa ---------------VVK-LKQIEHTLNEKR------ILQAVNF------PFLVKLEFSF PKA__PKACb ---------------VVK-LKQIEHTLNEKR------ILQAVNF------PFLVRLEYAF PKA__PKACg ---------------VVK-MKQVEHILNEKR------ILQAIDF------PFLVKLQFSF PKG__PKG1 ---------------IVD-TRQQEHIRSEKQ------IMQGAHS------DFIVRLYRTF PKG__PKG2 ---------------IVD-TKQQEHVYSEKR------ILEELCS------PFIVKLYRTF PKB__PDK1 ---------------IIK-ENKVPYVTRERD------VMSRLDH------PFFVKLYFTF YANK__YANK2 ---------------CIE-RDEVRNVFRELQ------IMQGLEH------PFLVNLWYSF YANK__YANK1 ---------------CVE-RNEVRNVFKELQ------IMQGLEH------PFLVNLWYSF YANK__YANK3 ---------------CIE-RDEVRNVFRELE------ILQEIEH------VFLVNLWYSF RSK__SgK494 ---------------VLQ-RDTVRQCKEEVS------IQRQINH------PFVHSLGDSW RSKL__RSKL2 QDRIALEPPRTSPNLLLAGEAPSTRPQREAEGEPTARTSTSGSSDL----PKAPGGHLHL RSKL__RSKL1 ----------------LAKEEPTSLFQRDSE------TK--GES----------G--LVL MAST__MASTL ---------------MIN-KNMTHQVQAERD------ALALSKS------PFIVHLYYSL : DMPK_GEK_MRCKb QDENH--------LYLVMDYYVGGDLLTLLSKFED-------------------KLPEDM DMPK_GEK_MRCKa QDDNN--------LYLVMDYYVGGDLLTLLSKFED-------------------RLPEDM DMPK_GEK_DMPK2 QDEEY--------LYLVMDYYAGGDLLTLLSRFED-------------------RLPPEL DMPK_GEK_DMPK1 QDENY--------LYLVMEYYVGGDLLTLLSKFGE-------------------RIPAEM DMPK_ROCK_ROCK2 QDDRY--------LYMVMEYMPGGDLVNLMSNYD---------------------VPEKW DMPK_ROCK_ROCK1 QDDRY--------LYMVMEYMPGGDLVNLMSNYD---------------------VPEKW DMPK__CRIK QDKNH--------LYLVMEYQPGGDLLSLLNRYED-------------------QLDENL NDR__NDR1 QDKLN--------LYLIMEFLPGGDMMTLLMKKD--------------------TLTEEE NDR__NDR2 QDKRN--------LYLIMEFLPGGDMMTLLMKKD--------------------TLTEEE NDR__LATS1 QDKDN--------LYFVMDYIPGGDMMSLLIRMG--------------------IFPESL NDR__LATS2 QDKDS--------LYFVMDYIPGGDMMSLLIRME--------------------VFPEHL MAST__MAST1 ETRRH--------LCMVMEYVEGGDCATLLKNIG--------------------ALPVEM MAST__MAST4 ETRRH--------LCMVMEYVEGGDCATLMKNMG--------------------PLPVDM MAST__MAST2 DTKRH--------LCMVMEYVEGGDCATLLKNIG--------------------ALPVDM MAST__MAST3 ETRRH--------LCMVMEYVEGGDCATLLKNMG--------------------PLPVDM AKT__AKT1 QTHDR--------LCFVMEYANGGELFFHLSRER--------------------VFSEDR AKT__AKT2 QTHDR--------LCFVMEYANGGELFFHLSRER--------------------VFTEER AKT__AKT3 QTKDR--------LCFVMEYVNGGELFFHLSRER--------------------VFSEDR SGK__SGK QTADK--------LYFVLDYINGGELFYHLQRER--------------------CFLEPR SGK__SGK3 QTTEK--------LYFVLDFVNGGELFFHLQRER--------------------SFPEHR SGK__SGK2 QTPEK--------LYFVLDYVNGGELFFHLQRER--------------------RFLEPR PKC_Alpha_PKCa QTVDR--------LYFVMEYVNGGDLMYHIQQVG--------------------KFKEPQ PKC_Alpha_PKCb QTMDR--------LYFVMEYVNGGDLMYHIQQVG--------------------RFKEPH PKC_Alpha_PKCg QTPDR--------LYFVMEYVTGGDLMYHIQQLG--------------------KFKEPH PKC_Eta_PKCh QTPDR--------LFFVMEFVNGGDLMFHIQKSR--------------------RFDEAR PKC_Eta_PKCe QTKDR--------LFFVMEYVNGGDLMFQIQRSR--------------------KFDEPR PKC_Delta_PKCd QTKDH--------LFFVMEFLNGGDLMYHIQDKG--------------------RFELYR PKC_Delta_PKCt QTKEN--------LFFVMEYLNGGDLMYHIQSCH--------------------KFDLSR PKC_Iota_PKCi QTESR--------LFFVIEYVNGGDLMFHMQRQR--------------------KLPEEH PKC_Iota_PKCz QTTSR--------LFLVIEYVNGGDLMFHMQRQR--------------------KLPEEH PKN__PKN1 QTPEH--------VCFVMEYSAGGDLMLHIHS-D--------------------VFSEPR PKN__PKN2 QTKEH--------VCFVMEYAAGGDLMMHIHT-D--------------------VFSEPR PKN__PKN3 QTSSH--------ARFVTEFVPGGDLMMQIHE-D--------------------VFPEPQ RSK_MSK_MSK1 QTETK--------LHLILDYINGGELFTHLSQRE--------------------RFTEHE RSK_MSK_MSK2 QTDAK--------LHLILDYVSGGEMFTHLYQRQ--------------------YFKEAE RSK_p70_p70S6K QTGGK--------LYLILEYLSGGELFMQLEREG--------------------IFMEDT RSK_p70_p70S6Kb QTGGK--------LYLILECLSGGELFTHLEREG--------------------IFLEDT RSK_RSK_RSK1 QTEGK--------LYLILDFLRGGDLFTRLSKEV--------------------MFTEED RSK_RSK_RSK2 QTEGK--------LYLILDFLRGGDLFTRLSKEV--------------------MFTEED RSK_RSK_RSK3 QTEGK--------LYLILDFLRGGDLFTRLSKEV--------------------MFTEED RSK_RSK_RSK4 QTEGK--------LYLILDFLRGGDVFTRLSKEV--------------------LFTEED GRK_BARK_BARK1 HTPDK--------LSFILDLMNGGDLHYHLSQHG--------------------VFSEAD GRK_BARK_BARK2 HTPDK--------LCFILDLMNGGDLHYHLSQHG--------------------VFSEKE GRK_GRK_GPRK4 ETKDA--------LCLVLTIMNGGDLKFHIYNLG------------------NPGFDEQR GRK_GRK_GPRK5 ETKDA--------LCLVLTIMNGGDLKFHIYNMG------------------NPGFEEER GRK_GRK_GPRK6 ETKDA--------LCLVLTLMNGGDLKFHIYHMG------------------QAGFPEAR GRK_GRK_RHOK ETKAD--------LCLVMTIMNGGDIRYHIYNVNEE----------------NPGFPEPR GRK_GRK_GPRK7 ESKTH--------LCLVMSLMNGGDLKFHIYNVG------------------TRGLDMSR PKA__PRKX HDERF--------LYMLMEYVPGGELFSYLRNRG--------------------RFSSTT PKA__PRKY HEERF--------LYMLMEYVPGGELFSYLRNRG--------------------HFSSTT PKA__PKACa KDNSN--------LYMVMEYVPGGEMFSHLRRIG--------------------RFSEPH PKA__PKACb KDNSN--------LYMVMEYVPGGEMFSHLRRIG--------------------RFSEPH PKA__PKACg KDNSY--------LYLVMEYVPGGEMFSRLQRVG--------------------RFSEPH PKG__PKG1 KDSKY--------LYMLMEACLGGELWTILRDRG--------------------SFEDST PKG__PKG2 KDNKY--------VYMLLEACLGGELWSILRDRG--------------------SFDEPT PKB__PDK1 QDDEK--------LYFGLSYAKNGELLKYIRKIG--------------------SFDETC YANK__YANK2 QDEED--------MFMVVDLLLGGDLRYHLQQNV--------------------HFTEGT YANK__YANK1 QDEED--------MFMVVDLLLGGDLRYHLQQNV--------------------HFKEET YANK__YANK3 QDEED--------MFMVVDLLLGGDLRYHLQQNV--------------------QFSEDT RSK__SgK494 QGKRH--------LFIMCSYCS-TDLYSLWSAVG--------------------CFPEAS RSKL__RSKL2 QARRAGQNSDAGPPRGLTWVPEGAGPVLGGCGRGMDQSCLSADGAGRGCGRATWSVREEQ RSKL__RSKL1 EGDKE-----------IHQIFEDLDKKLALASR--------------------FYIPEGC MAST__MASTL QSANN--------VYLVMEYLIGGDVKSLLHIYG--------------------YFDEEM . . DMPK_GEK_MRCKb ARFYIGEMVLAIDSIHQ-LHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMN--------- DMPK_GEK_MRCKa ARFYLAEMVIAIDSVHQ-LHYVHRDIKPDNILMDMNGHIRLADFGSCLKLM--------- DMPK_GEK_DMPK2 AQFYLAEMVLAIHSLHQ-LGYVHRDVKPDNVLLDVNGHIRLADFGSCLRLN--------- DMPK_GEK_DMPK1 ARFYLAEIVMAIDSVHR-LGYVHRDIKPDNILLDRCGHIRLADFGSCLKLR--------- DMPK_ROCK_ROCK2 AKFYTAEVVLALDAIHS-MGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMD--------- DMPK_ROCK_ROCK1 ARFYTAEVVLALDAIHS-MGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMN--------- DMPK__CRIK IQFYLAELILAVHSVHL-MGYVHRDIKPENILVDRTGHIKLVDFGSAAKMN--------- NDR__NDR1 TQFYIAETVLAIDSIHQ-LGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYR NDR__NDR2 TQFYISETVLAIDAIHQ-LGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFYR NDR__LATS1 ARFYIAELTCAVESVHK-MGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQ NDR__LATS2 ARFYIAELTLAIESVHK-MGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQ MAST__MAST1 ARMYFAETVLALEYLHN-YGIVHRDLKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLYE MAST__MAST4 ARMYFAETVLALEYLHN-YGIVHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMSMTTNLYE MAST__MAST2 VRLYFAETVLALEYLHN-YGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYE MAST__MAST3 ARLYFAETVLALEYLHN-YGIVHRDLKPDNLLITSLGHIKLTDFGLSKIGLMSMATNLYE AKT__AKT1 ARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKD------- AKT__AKT2 ARFYGAEIVSALEYLHS-RDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISD------- AKT__AKT3 TRFYGAEIVSALDYLHS-GKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITD------- SGK__SGK ARFYAAEIASALGYLHS-LNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEH------- SGK__SGK3 ARFYAAEIASALGYLHS-IKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAI------- SGK__SGK2 ARFYAAEVASAIGYLHS-LNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEP------- PKC_Alpha_PKCa AVFYAAEISIGLFFLHK-RGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMD------- PKC_Alpha_PKCb AVFYAAEIAIGLFFLQS-KGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWD------- PKC_Alpha_PKCg AAFYAAEIAIGLFFLHN-QGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFP------- PKC_Eta_PKCh ARFYAAEIISALMFLHD-KGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICN------- PKC_Eta_PKCe SRFYAAEVTSALMFLHQ-HGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILN------- PKC_Delta_PKCd ATFYAAEIMCGLQFLHS-KGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFG------- PKC_Delta_PKCt ATFYAAEIILGLQFLHS-KGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLG------- PKC_Iota_PKCi ARFYSAEISLALNYLHE-RGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRP------- PKC_Iota_PKCz ARFYAAEICIALNFLHE-RGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGP------- PKN__PKN1 AIFYSACVVLGLQFLHE-HKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGY------- PKN__PKN2 AVFYAACVVLGLQYLHE-HKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGY------- PKN__PKN3 ARFYVACVVLGLQFLHE-KKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGF------- RSK_MSK_MSK1 VQIYVGEIVLALEHLHK-LGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVAD------- RSK_MSK_MSK2 VRVYGGEIVLALEHLHK-LGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTE------- RSK_p70_p70S6K ACFYLAEISMALGHLHQ-KGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHD------- RSK_p70_p70S6Kb ACFYLAEITLALGHLHS-QGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHE------- RSK_RSK_RSK1 VKFYLAELALALDHLHS-LGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDH------- RSK_RSK_RSK2 VKFYLAELALALDHLHS-LGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDH------- RSK_RSK_RSK3 VKFYLAELALGLDHLHS-LGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDH------- RSK_RSK_RSK4 VKFYLAELALALDHLHQ-LGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQ------- GRK_BARK_BARK1 MRFYAAEIILGLEHMHN-RFVVYRDLKPANILLDEHGHVRISDLGLACDFSKK------- GRK_BARK_BARK2 MRFYATEIILGLEHVHN-RFVVYRDLKPANILLDEHGHARISDLGLACDFSKK------- GRK_GRK_GPRK4 AVFYAAELCCGLEDLQR-ERIVYRDLKPENILLDDRGHIRISDLGLATEIPEG------- GRK_GRK_GPRK5 ALFYAAEILCGLEDLHR-ENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEG------- GRK_GRK_GPRK6 AVFYAAEICCGLEDLHR-ERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEG------- GRK_GRK_RHOK ALFYTAQIICGLEHLHQ-RRIVYRDLKPENVLLDNDGNVRISDLGLAVELLDG------- GRK_GRK_GPRK7 VIFYSAQIACGMLHLHE-LGIVYRDMKPENGLLDDLGNCRLSDLGLAVEMKGG------- PKA__PRKX GLFYSAEIICAIEYLHS-KEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVD-------- PKA__PRKY GLFYSAEIICAIEYLHS-KEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVD-------- PKA__PKACa ARFYAAQIVLTFEYLHS-LDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG-------- PKA__PKACb ARFYAAQIVLTFEYLHS-LDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKG-------- PKA__PKACg ACFYAAQVVLAVQYLHS-LDLIHRDLKPENLLIDQQGYLQVTDFGFAKRVKG-------- PKG__PKG1 TRFYTACVVEAFAYLHS-KGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFG------- PKG__PKG2 SKFCVACVTEAFDYLHR-LGIIYRDLKPENLILDAEGYLKLVDFGFAKKIGSG------- PKB__PDK1 TRFYTAEIVSALEYLHG-KGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPE------- YANK__YANK2 VKLYICELALALEYLQR-YHIIHRDIKPDNILLDEHGHVHITDFNIATVVKGA------- YANK__YANK1 VKLFICELVMALDYLQN-QRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRE------- YANK__YANK3 VRLYICEMALALDYLRG-QHIIHRDVKPDNILLDERGHAHLTDFNIATIIKDG------- RSK__SgK494 IRLFAAELVLVLCYLHD-LGIMHRDVKMENILLDERGHLKLTDFGLSRHVPQG------- RSKL__RSKL2 VKQWAAEMLVALEALHE-QGVLCRDLHPGNLLLDQAGHIRLTYFGQWSEVEP-------- RSKL__RSKL1 IQRWAAEMVVALDALHR-EGIVCRDLNPNNILLNDRGHIQLTYFSRWSEVED-------- MAST__MASTL AVKYISEVALALDYLHR-HGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNR------- . :: : **:: * :: : . DMPK_GEK_MRCKb -------------------------------------DDGTVQSSVAVGTPDYISP---- DMPK_GEK_MRCKa -------------------------------------EDGTVQSSVAVGTPDYISP---- DMPK_GEK_DMPK2 -------------------------------------TNGMVDSSVAVGTPDYISP---- DMPK_GEK_DMPK1 -------------------------------------ADGTVRSLVAVGTPDYLSP---- DMPK_ROCK_ROCK2 -------------------------------------ETGMVHCDTAVGTPDYISP---- DMPK_ROCK_ROCK1 -------------------------------------KEGMVRCDTAVGTPDYISP---- DMPK__CRIK -------------------------------------SNKMVNAKLPIGTPDYMAP---- NDR__NDR1 NLNHSLPSDFTFQNMNSKR------------KAETWKRNRRQLAFSTVGTPDYIAP---- NDR__NDR2 NLTHNPPSDFSFQNMNSKR------------KAETWKKNRRQLAYSTVGTPDYIAP---- NDR__LATS1 SGDHPRQDSMDFSNEWGDPSSCRCGDRLKPLERRAARQHQRCLAHSLVGTPNYIAP---- NDR__LATS2 KGSHVRQDSMEPSDLWDDVSNCRCGDRLKTLEQRARKQHQRCLAHSLVGTPNYIAP---- MAST__MAST1 G--------------------------------HIEKDAREFLDKQVCGTPEYIAP---- MAST__MAST4 G--------------------------------HIEKDAREFLDKQVCGTPEYIAP---- MAST__MAST2 G--------------------------------HIEKDAREFLDKQVCGTPEYIAP---- MAST__MAST3 G--------------------------------HIEKDAREFIDKQVCGTPEYIAP---- AKT__AKT1 --------------------------------------G--ATMKTFCGTPEYLAP---- AKT__AKT2 --------------------------------------G--ATMKTFCGTPEYLAP---- AKT__AKT3 --------------------------------------A--ATMKTFCGTPEYLAP---- SGK__SGK --------------------------------------N--STTSTFCGTPEYLAP---- SGK__SGK3 --------------------------------------S--DTTTTFCGTPEYLAP---- SGK__SGK2 --------------------------------------E--DTTSTFCGTPEYLAP---- PKC_Alpha_PKCa --------------------------------------G--VTTRTFCGTPDYIAP---- PKC_Alpha_PKCb --------------------------------------G--VTTKTFCGTPDYIAP---- PKC_Alpha_PKCg --------------------------------------G--TTTRTFCGTPDYIAP---- PKC_Eta_PKCh --------------------------------------G--VTTATFCGTPDYIAP---- PKC_Eta_PKCe --------------------------------------G--VTTTTFCGTPDYIAP---- PKC_Delta_PKCd --------------------------------------E--SRASTFCGTPDYIAP---- PKC_Delta_PKCt --------------------------------------D--AKTNTFCGTPDYIAP---- PKC_Iota_PKCi --------------------------------------G--DTTSTFCGTPNYIAP---- PKC_Iota_PKCz --------------------------------------G--DTTSTFCGTPNYIAP---- PKN__PKN1 --------------------------------------G--DRTSTFCGTPEFLAP---- PKN__PKN2 --------------------------------------G--DRTSTFCGTPEFLAP---- PKN__PKN3 --------------------------------------G--DRTSTFCGTPEFLAP---- RSK_MSK_MSK1 --------------------------------------ET-ERAYSFCGTIEYMAP---- RSK_MSK_MSK2 --------------------------------------EK-ERTFSFCGTIEYMAP---- RSK_p70_p70S6K --------------------------------------G--TVTHTFCGTIEYMAP---- RSK_p70_p70S6Kb --------------------------------------G--AVTHTFCGTIEYMAP---- RSK_RSK_RSK1 --------------------------------------D--KRAYSFCGTIEYMAP---- RSK_RSK_RSK2 --------------------------------------E--KKAYSFCGTVEYMAP---- RSK_RSK_RSK3 --------------------------------------E--KKAYSFCGTVEYMAP---- RSK_RSK_RSK4 --------------------------------------E--KKAYSFCGTVEYMAP---- GRK_BARK_BARK1 --------------------------------------K----PHASVGTHGYMAP---- GRK_BARK_BARK2 --------------------------------------K----PHASVGTHGYMAP---- GRK_GRK_GPRK4 --------------------------------------Q---RVRGRVGTVGYMAP---- GRK_GRK_GPRK5 --------------------------------------D---LIRGRVGTVGYMAP---- GRK_GRK_GPRK6 --------------------------------------Q---TIKGRVGTVGYMAP---- GRK_GRK_RHOK --------------------------------------Q--SKTKGYAGTPGFMAP---- GRK_GRK_GPRK7 --------------------------------------K---PITQRAGTNGYMAP---- PKA__PRKX ------------------------------------------RTWTLCGTPEYLAP---- PKA__PRKY ------------------------------------------RTWTLCGTPEYLAP---- PKA__PKACa ------------------------------------------RTWTLCGTPEYLAP---- PKA__PKACb ------------------------------------------RTWTLCGTPEYLAP---- PKA__PKACg ------------------------------------------RTWTLCGTPEYLAP---- PKG__PKG1 --------------------------------------K---KTWTFCGTPEYVAP---- PKG__PKG2 --------------------------------------Q---KTWTFCGTPEYVAP---- PKB__PDK1 --------------------------------------SKQARANSFVGTAQYVSP---- YANK__YANK2 -----------------------------------------ERASSMAGTKPYMAP---- YANK__YANK1 -----------------------------------------TQITTMAGTKPYMAP---- YANK__YANK3 -----------------------------------------ERATALAGTKPYMAP---- RSK__SgK494 -----------------------------------------AQAYTICGTLQYMAP---- RSKL__RSKL2 ------------------------------------------QCCGEAVDNLYSAP---- RSKL__RSKL1 ------------------------------------------SCDSDAIERMYCAP---- MAST__MASTL ----------------------------------------DINMMDILTTPSMAKPRQDY * DMPK_GEK_MRCKb -----EILQ---AMEDG--MGKYGPECDWWSLGVCMYEMLYGETPFYAE---------SL DMPK_GEK_MRCKa -----EILQ---AMEDG--KGRYGPECDWWSLGVCMYEMLYGETPFYAE---------SL DMPK_GEK_DMPK2 -----EILQ---AMEEG--KGHYGPQCDWWSLGVCAYELLFGETPFYAE---------SL DMPK_GEK_DMPK1 -----EILQ---AVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYAD---------ST DMPK_ROCK_ROCK2 -----EVLK---SQGGD---GFYGRECDWWSVGVFLYEMLVGDTPFYAD---------SL DMPK_ROCK_ROCK1 -----EVLK---SQGGD---GYYGRECDWWSVGVFLYEMLVGDTPFYAD---------SL DMPK__CRIK -----EVLT---VMNGD-GKGTYGLDCDWWSVGVIAYEMIYGRSPFAEG---------TS NDR__NDR1 -----EVFM---QTG-------YNKLCDWWSLGVIMYEMLIGYPPFCSE---------TP NDR__NDR2 -----EVFM---QTG-------YNKLCDWWSLGVIMYEMLIGYPPFCSE---------TP NDR__LATS1 -----EVLL---RTG-------YTQLCDWWSVGVILFEMLVGQPPFLAQ---------TP NDR__LATS2 -----EVLL---RKG-------YTQLCDWWSVGVILFEMLVGQPPFLAP---------TP MAST__MAST1 -----EVIL---RQG-------YGKPVDWWAMGIILYEFLVGCVPFFGD---------TP MAST__MAST4 -----EVIL---RQG-------YGKPVDWWAMGIILYEFLVGCVPFFGD---------TP MAST__MAST2 -----EVIL---RQG-------YGKPVDWWAMGIILYEFLVGCVPFFGD---------TP MAST__MAST3 -----EVIF---RQG-------YGKPVDWWAMGVVLYEFLVGCVPFFGD---------TP AKT__AKT1 -----EVLE---DND-------YGRAVDWWGLGVVMYEMMCGRLPFYNQ---------DH AKT__AKT2 -----EVLE---DND-------YGRAVDWWGLGVVMYEMMCGRLPFYNQ---------DH AKT__AKT3 -----EVLE---DND-------YGRAVDWWGLGVVMYEMMCGRLPFYNQ---------DH SGK__SGK -----EVLH---KQP-------YDRTVDWWCLGAVLYEMLYGLPPFYSR---------NT SGK__SGK3 -----EVIR---KQP-------YDNTVDWWCLGAVLYEMLYGLPPFYCR---------DV SGK__SGK2 -----EVLR---KEP-------YDRAVDWWCLGAVLYEMLHGLPPFYSQ---------DV PKC_Alpha_PKCa -----EIIA---YQP-------YGKSVDWWAYGVLLYEMLAGQPPFDGE---------DE PKC_Alpha_PKCb -----EIIA---YQP-------YGKSVDWWAFGVLLYEMLAGQAPFEGE---------DE PKC_Alpha_PKCg -----EIIA---YQP-------YGKSVDWWSFGVLLYEMLAGQPPFDGE---------DE PKC_Eta_PKCh -----EILQ---EML-------YGPAVDWWAMGVLLYEMLCGHAPFEAE---------NE PKC_Eta_PKCe -----EILQ---ELE-------YGPSVDWWALGVLMYEMMAGQPPFEAD---------NE PKC_Delta_PKCd -----EILQ---GLK-------YTFSVDWWSFGVLLYEMLIGQSPFHGD---------DE PKC_Delta_PKCt -----EILL---GQK-------YNHSVDWWSFGVLLYEMLIGQSPFHGQ---------DE PKC_Iota_PKCi -----EILR---GED-------YGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTE PKC_Iota_PKCz -----EILR---GEE-------YGFSVDWWALGVLMFEMMAGRSPFDII--TDNPDMNTE PKN__PKN1 -----EVLT---DTS-------YTRAVDWWGLGVLLYEMLVGESPFPGD---------DE PKN__PKN2 -----EVLT---ETS-------YTRAVDWWGLGVLIYEMLVGESPFPGD---------DE PKN__PKN3 -----EVLT---QEA-------YTQAVDWWALGVLLYEMLVGECPFPGD---------TE RSK_MSK_MSK1 -----DIVRG-GDSG-------HDKAVDWWSLGVLMYELLTGASPFTVD---------GE RSK_MSK_MSK2 -----EIIR--SKTG-------HGKAVDWWSLGILLFELLTGASPFTLE---------GE RSK_p70_p70S6K -----EILM---RSG-------HNRAVDWWSLGALMYDMLTGAPPFTGE---------NR RSK_p70_p70S6Kb -----EILV---RSG-------HNRAVDWWSLGALMYDMLTGSPPFTAE---------NR RSK_RSK_RSK1 -----EVVN---RRG-------HTQSADWWSFGVLMFEMLTGSLPFQGK---------DR RSK_RSK_RSK2 -----EVVN---RRG-------HTQSADWWSFGVLMFEMLTGTLPFQGK---------DR RSK_RSK_RSK3 -----EVVN---RQG-------HSHSADWWSYGVLMFEMLTGSLPFQGK---------DR RSK_RSK_RSK4 -----EVVN---RRG-------HSQSADWWSYGVLMFEMLTGTLPFQGK---------DR GRK_BARK_BARK1 -----EVLQ--KGVA-------YDSSADWFSLGCMLFKLLRGHSPFRQH---------KT GRK_BARK_BARK2 -----EVLQ--KGTA-------YDSSADWFSLGCMLFKLLRGHSPFRQH---------KT GRK_GRK_GPRK4 -----EVVN--NEK--------YTFSPDWWGLGCLIYEMIQGHSPFKKY---------KE GRK_GRK_GPRK5 -----EVLN--NQR--------YGLSPDYWGLGCLIYEMIEGQSPFRGR---------KE GRK_GRK_GPRK6 -----EVVK--NER--------YTFSPDWWALGCLLYEMIAGQSPFQQR---------KK GRK_GRK_RHOK -----ELLQ--GEE--------YDFSVDYFALGVTLYEMIAARGPFRAR---------GE GRK_GRK_GPRK7 -----EILM--EKVS-------YSYPVDWFAMGCSIYEMVAGRTPFKDY---------KE PKA__PRKX -----EVIQ---SKG-------HGRAVDWWALGILIFEMLSGFPPFFDD----------- PKA__PRKY -----EVIQ---SKG-------HGRAVDWWALGILIFEMLSGFPPFFDD----------- PKA__PKACa -----EIIL---SKG-------YNKAVDWWALGVLIYEMAAGYPPFFAD----------- PKA__PKACb -----EIIL---SKG-------YNKAVDWWALGVLIYEMAAGYPPFFAD----------- PKA__PKACg -----EIIL---SKG-------YNKAVDWWALGVLIYEMAVGFPPFYAD----------- PKG__PKG1 -----EIIL---NKG-------HDISADYWSLGILMYELLTGSPPFSGP----------- PKG__PKG2 -----EVIL---NKG-------HDFSVDFWSLGILVYELLTGNPPFSGV----------- PKB__PDK1 -----ELLT---EKS-------ACKSSDLWALGCIIYQLVAGLPPFRAG----------- YANK__YANK2 -----EVFQVYMDRGPG-----YSYPVDWWSLGITAYELLRGWRPYEIH---------SV YANK__YANK1 -----EMFSS--RKGAG-----YSFAVDWWSLGVTAYELLRGRRPYHIR---------SS YANK__YANK3 -----EIFHSFVNGGTG-----YSFEVDWWSVGVMAYELLRGWRPYDIH---------SS RSK__SgK494 -----EVLS---GGP-------YNHAADWWSLGVLLFSLATGKFPVAAER--------DH RSKL__RSKL2 -----EVGG----IS------ELTEACDWWSFGSLLYELLTGMALSQSH----------- RSKL__RSKL1 -----EVGA----IT------EETEACDWWSLGAVLFELLTGKTLVECH----------- MAST__MASTL SRTPGQVLSLISSLGFN-----TPIAEKNQDPANILSACLSETSQLSQG-------LVCP :: . . DMPK_GEK_MRCKb VET----YGKIMNHEERFQFPSHVTDVSEEAKDLIQRLIC-SRERRLGQ----NGIEDFK DMPK_GEK_MRCKa VET----YGKIMNHKERFQFPAQVTDVSENAKDLIRRLIC-SREHRLGQ----NGIEDFK DMPK_GEK_DMPK2 VET----YGKIMNHEDHLQFPPDVPDVPASAQDLIRQLLC-RQEERLGR----GGLDDFR DMPK_GEK_DMPK1 AET----YGKIVHYKEHLSLPLVDEGVPEEARDFIQRLLC-PPETRLGR----GGAGDFR DMPK_ROCK_ROCK2 VGT----YSKIMDHKNSLCFP-EDAEISKHAKNLICAFLT-DREVRLGR----NGVEEIR DMPK_ROCK_ROCK1 VGT----YSKIMNHKNSLTFP-DDNDISKEAKNLICAFLT-DREVRLGR----NGVEEIK DMPK__CRIK ART----FNNIMNFQRFLKFP-DDPKVSSDFLDLIQSLLC-GQKERLK-------FEGLC NDR__NDR1 QET----YKKVMNWKETLTFP-PEVPISEKAKDLILRFCC-EWEHRIGA----PGVEEIK NDR__NDR2 QET----YRKVMNWKETLVFP-PEVPISEKAKDLILRFCI-DSENRIGN----SGVEEIK NDR__LATS1 LET----QMKVINWQTSLHIP-PQAKLSPEASDLIIKLCR-GPEDRLGK----NGADEIK NDR__LATS2 TET----QLKVINWENTLHIP-AQVKLSPEARDLITKLCC-SADHRLGR----NGADDLK MAST__MAST1 EEL----FGQVIS--DDILWPEGDEALPTEAQLLISSLLQTNPLVRLGA----GGAFEVK MAST__MAST4 EEL----FGQVIS--DEINWPEKDE----------------------------------- MAST__MAST2 EEL----FGQVIS--DEIVWPEGDEALPPDAQDLTSKLLHQNPLERLGT----GSAYEVK MAST__MAST3 EEL----FGQVVS--DEIMWPEGDEALPADAQDLITRLLRQSPLDRLGT----GGTHEVK AKT__AKT1 EKL----FELILME--EIRFP---RTLGPEAKSLLSGLLKKDPKQRLGGGS--EDAKEIM AKT__AKT2 ERL----FELILME--EIRFP---RTLSPEAKSLLAGLLKKDPKQRLGGGP--SDAKEVM AKT__AKT3 EKL----FELILME--DIKFP---RTLSSDAKSLLSGLLIKDPNKRLGGGP--DDAKEIM SGK__SGK AEM----YDNILNK--PLQLK---PNITNSARHLLEGLLQKDRTKRLG-AK--DDFMEIK SGK__SGK3 AEM----YDNILHK--PLSLR---PGVSLTAWSILEELLEKDRQNRLG-AK--EDFLEIQ SGK__SGK2 SQM----YENILHQ--PLQIP---GGRTVAACDLLQSLLHKDQRQRLG-SK--ADFLEIK PKC_Alpha_PKCa DEL----FQSIMEH--NVSYP---KSLSKEAVSICKGLMTKHPAKRLGCGP--EGERDVR PKC_Alpha_PKCb DEL----FQSIMEH--NVAYP---KSMSKEAVAICKGLMTKHPGKRLGCGP--EGERDIK PKC_Alpha_PKCg EEL----FQAIMEQ--TVTYP---KSLSREAVAICKGFLTKHPGKRLGSGP--DGEPTIR PKC_Eta_PKCh DDL----FEAILND--EVVYP---TWLHEDATGILKSFMTKNPTMRLGSLT-QGGEHAIL PKC_Eta_PKCe DDL----FESILHD--DVLYP---VWLSKEAVSILKAFMTKNPHKRLGCVASQNGEDAIK PKC_Delta_PKCd DEL----FESIRVD--TPHYP---RWITKESKDILEKLFEREPTKRLGVTG------NIK PKC_Delta_PKCt EEL----FHSIRMD--NPFYP---RWLEKEAKDLLVKLFVREPEKRLGVRG------DIR PKC_Iota_PKCi DYL----FQVILEK--QIRIP---RSLSVKAASVLKSFLNKDPKERLGCHP-QTGFADIQ PKC_Iota_PKCz DYL----FQVILEK--PIRIP---RFLSVKASHVLKGFLNKDPKERLGCRP-QTGFSDIK PKN__PKN1 EEV----FDSIVND--EVRYP---RFLSAEAIGIMRRLLRRNPERRLGSSE--RDAEDVK PKN__PKN2 EEV----FDSIVND--EVRYP---RFLSTEAISIMRRLLRRNPERRLGASE--KDAEDVK PKN__PKN3 EEV----FDCIVNM--DAPYP---GFLSVQGLEFIQKLLQKCPEKRLGAGE--QDAEEIK RSK_MSK_MSK1 KNSQAEISRRILKS--EPPYP---QEMSALAKDLIQRLLMKDPKKRLGCGP--RDADEIK RSK_MSK_MSK2 RNTQAEVSRRILKC--SPPFP---PRIGPVAQDLLQRLLCKDPKKRLGAGP--QGAQEVR RSK_p70_p70S6K KKT----IDKILKC--KLNLP---PYLTQEARDLLKKLLKRNAASRLGAGP--GDAGEVQ RSK_p70_p70S6Kb KKT----MDKIIRG--KLALP---PYLTPDARDLVKKFLKRNPSQRIGGGP--GDAADVQ RSK_RSK_RSK1 KET----MALILKA--KLGMP---QFLSGEAQSLLRALFKRNPCNRLGAGI--DGVEEIK RSK_RSK_RSK2 KET----MTMILKA--KLGMP---QFLSPEAQSLLRMLFKRNPANRLGAGP--DGVEEIK RSK_RSK_RSK3 KET----MTLILKA--KLGMP---QFLSTEAQSLLRALFKRNPANRLGSGP--DGAEEIK RSK_RSK_RSK4 NET----MNMILKA--KLGMP---QFLSAEAQSLLRMLFKRNPANRLGS----EGVEEIK GRK_BARK_BARK1 KDK-HEIDRMTLTM--AVELP---DSFSPELRSLLEGLLQRDVNRRLGCLG--RGAQEVK GRK_BARK_BARK2 KDK-HEIDRMTLTV--NVELP---DTFSPELKSLLEGLLQRDVSKRLGCHG--GGSQEVK GRK_GRK_GPRK4 KVKWEEVDQRIKND--TEEYS---EKFSEDAKSICRMLLTKNPSKRLGCRG--EGAAGVK GRK_GRK_GPRK5 KVKREEVDRRVLET--EEVYS---HKFSEEAKSICKMLLTKDAKQRLGCQE--EGAAEVK GRK_GRK_GPRK6 KIKREEVERLVKEV--PEEYS---ERFSPQARSLCSQLLCKDPAERLGCRG--GSAREVK GRK_GRK_RHOK KVENKELKHRIISE--PVKYP---DKFSQASKDFCEALLEKDPEKRLGFRD--ETCDKLR GRK_GRK_GPRK7 KVSKEDLKQRTLQD--EVKFQH--DNFTEEAKDICRLFLAKKPEQRLRSR---EKSDDPR PKA__PRKX NPFGI--YQKILAG--KIDFP---RHLDFHVKDLIKKLLVVDRTRRLG--NMKNGANDVK PKA__PRKY NPFGI--YQKILAG--KLYFP---R----------------------------------- PKA__PKACa QPIQI--YEKIVSG--KVRFP---SHFSSDLKDLLRNLLQVDLTKRFG--NLKNGVNDIK PKA__PKACb QPIQI--YEKIVSG--KVRFP---SHFSSDLKDLLRNLLQVDLTKRFG--NLKNGVSDIK PKA__PKACg QPIQI--YEKIVSG--RVRFP---SKLSSDLKDLLRSLLQVDLTKRFG--NLRNGVGDIK PKG__PKG1 DPMKT--YNIILRGIDMIEFP---KKIAKNAANLIKKLCRDNPSERLG--NLKNGVKDIQ PKG__PKG2 DQMMT--YNLILKGIEKMDFP---RKITRRPEDLIRRLCRQNPTERLG--NLKNGINDIK PKB__PDK1 NEYLI--FQKIIKL--EYDFP---EKFFPKARDLVEKLLVLDATKRLGC-EEMEGYGPLK YANK__YANK2 TPI-----DEILNMFKVERVHYS-STWCKGMVALLRKLLTKDPESRVS------SLHDIQ YANK__YANK1 TSS-----KEIVHTFETTVVTYP-SAWSQEMVSLLKKLLEPNPDQRFS------QLSDVQ YANK__YANK3 NAV-----ESLVQLFSTVSVQYV-PTWSKEMVALLRKLLTVNPEHRLS------SLQDVQ RSK__SgK494 VAM----LASVTHS--DSEIP---ASLNQGLSLLLHELLCQNPLHRLR------YLHHFQ RSKL__RSKL2 P--------SGIQAHTQLQLP---EWLSRPAASLLTELLQFEPTRRLGMGE--GGVSKLK RSKL__RSKL1 P--------AGINTHTTLNMP---ECVSEEARSLIQQLLQFNPLERLGAGV--AGVEDIK MAST__MASTL MSVDQKDTTPYSSKLLKSCLETVASNPGMPVKCLTSNLLQ--SRKRLAT-----SSASSQ DMPK_GEK_MRCKb KHAFF DMPK_GEK_MRCKa KHPFF DMPK_GEK_DMPK2 NHPFF DMPK_GEK_DMPK1 THPFF DMPK_ROCK_ROCK2 QHPFF DMPK_ROCK_ROCK1 RHLFF DMPK__CRIK CHPFF NDR__NDR1 SNSFF NDR__NDR2 GHPFF NDR__LATS1 AHPFF NDR__LATS2 AHPFF MAST__MAST1 QHSFF MAST__MAST4 ----- MAST__MAST2 QHPFF MAST__MAST3 QHPFF AKT__AKT1 QHRFF AKT__AKT2 EHRFF AKT__AKT3 RHSFF SGK__SGK SHVFF SGK__SGK3 NHPFF SGK__SGK2 NHVFF PKC_Alpha_PKCa EHAFF PKC_Alpha_PKCb EHAFF PKC_Alpha_PKCg AHGFF PKC_Eta_PKCh RHPFF PKC_Eta_PKCe QHPFF PKC_Delta_PKCd IHPFF PKC_Delta_PKCt QHPLF PKC_Iota_PKCi GHPFF PKC_Iota_PKCz SHAFF PKN__PKN1 KQPFF PKN__PKN2 KHPFF PKN__PKN3 VQPFF RSK_MSK_MSK1 EHLFF RSK_MSK_MSK2 NHPFF RSK_p70_p70S6K AHPFF RSK_p70_p70S6Kb RHPFF RSK_RSK_RSK1 RHPFF RSK_RSK_RSK2 RHSFF RSK_RSK_RSK3 RHVFY RSK_RSK_RSK4 RHLFF GRK_BARK_BARK1 ESPFF GRK_BARK_BARK2 EHSFF GRK_GRK_GPRK4 QHPVF GRK_GRK_GPRK5 RHPFF GRK_GRK_GPRK6 EHPLF GRK_GRK_RHOK AHPLF GRK_GRK_GPRK7 KHHFF PKA__PRKX HHRWF PKA__PRKY ----- PKA__PKACa NHKWF PKA__PKACb THKWF PKA__PKACg NHKWF PKG__PKG1 KHKWF PKG__PKG2 KHRWL PKB__PDK1 AHPFF YANK__YANK2 SVPYL YANK__YANK1 NFPYM YANK__YANK3 AAPAL RSK__SgK494 VHPFF RSKL__RSKL2 SHPFF RSKL__RSKL1 SHPFF MAST__MASTL SHTFI