CLUSTAL W (1.8) multiple sequence alignment CAMKL_AMPK_AMPKa1 YILGDT-LGVGTFGKVKVGKHELTGHKVAVKILNRQKI--RS----LD-V CAMKL_AMPK_AMPKa2 YVLGDT-LGVGTFGKVKIGEHQLTGHKVAVKILNRQKI--RS----LD-V CAMKL_BRSK_BRSK2 YRLEKT-LGKGQTGLVKLGVHCVTCQKVAIKIVNREKL---S----ES-V CAMKL_BRSK_BRSK1 YRLEKT-LGKGQTGLVKLGVHCITGQKVAIKIVNREKL---S----ES-V CAMKL_MARK_MARK2 YRLLKT-IGKGNFAKVKLARHILTGKEVAVKIIDKTQL---N----SS-S CAMKL_MARK_MARK1 YRLQKT-IGKGNFAKVKLARHVLTGREVAVKIIDKTQL---N----PT-S CAMKL_MARK_MARK3 YRLLKT-IGKGNFAKVKLARHILTGREVAIKIIDKTQL---N----PT-S CAMKL_MARK_MARK4 YRLLRT-IGKGNFAKVKLARHILTGREVAIKIIDKTQL---N----PS-S CAMKL_QIK_QIK YDIEGT-LGKGNFAVVKLGRHRITKTEVAIKIIDKSQL---D----AV-N CAMKL_QIK_SIK YDIERT-LGKGNFAVVKLARHRVTKTQVAIKIIDKTRL---D----SS-N CAMKL_QIK_QSK YEIDRT-IGKGNFAVVKRATHLVTKAKVAIKIIDKTQL---D----EE-N CAMKL_NuaK_NuaK1 YELQET-LGKGTYGKVKRATERFSGRVVAIKSIRKDKI--KD----EQ-D CAMKL_NuaK_NuaK2 YEFLET-LGKGTYGKVKKARE-SSGRLVAIKSIRKDKI--KD----EQ-D CAMKL_HUNK_HUNK YLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRA--KK----DTYV CAMKL_MELK_MELK YELHET-IGTGGFAKVKLACHILTGEMVAIKIMDKNTL--GS----D--- CAMKL_NIM1_NIM1 YRIRGE-IGSGNFSQVKLGIHSLTKEKVAIKILDKTKL--DQ----KT-- CAMKL_SNRK_SNRK YDLDKT-LGRGHFACGTCSRHVFTGEKVAVKVIDKTKL--DT----LA-- CAMKL_CHK1_CHK1 WDLVQT-LGEGAYGEVQLAVNRVTEEAVAVKIVDMKRA--VD----CP-- CAMKL_LKB_LKB1 YLMGDL-LGEGSYGKVKEVLDSETLCRRAVKILKKKKL--RR----IPNG TSSK__SSTK YKLGRT-IGEGSYSKVKVATSKKYKGTVAIKVVDRRRA--PP----DFVN TSSK__TSSK3 YQLGKT-IGEGTYSKVKEAFSKKHQRKVAIKVIDKMGG--PS----EFIQ TSSK__TSSK2 YIVGIN-LGKGSYAKVKSAYSERLKFNVAVKIIDRRKT--PT----DFVE TSSK__TSSK1 YLLGIN-LGEGSYAKVKSAYSERLKFNVAIKIIDRKKA--PA----DFLE TSSK__TSSK4 YEVGKA-IGHGSYGSVYEAFYTKQKVMVAVKIISKKKA--SD----DYLN PIM__PIM3 YQVGAV-LGSGGFGTVYAGSRIADGLPVAVKHVVKERV--TE--WGSLG- PIM__PIM1 YQVGPL-LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRI--SD--WGELPN PIM__PIM2 YRLGPL-LGKGGFGTVFAGHRLTDRLQVAIKVIPRNRV--LG--WSPLSD CAMKL_PASK_PASK YSTMSP-LGSGAFGFVWTAVDKEKNKEVVVKFIKKEKV--LEDCWIEDPK CAMK-Unique__STK33 YTFGRI-LGKGSFGIVIEATDKETETKWAIKKVNKEKA--GS------SA DAPK__DAPK1 YDTGEE-LGSGQFAVVKKCREKSTGLQYAAKFIKKRRT--KSSR--RGVS DAPK__DAPK3 YEMGEE-LGSGQFAIVRKCRQKGTGKEYAAKFIKKRRL--SSSR--RGVS DAPK__DAPK2 YDIGEE-LGSGQFAIVKKCREKSTGLEYAAKFIKKRQS--RASR--RGVS DAPK__DRAK1 LCPGRE-LGRGKFAVVRKCIKKDSGKEFAAKFMRKRRK--GQD------C DAPK__DRAK2 ILTSKE-LGRGKFAVVRQCISKSTGQEYAAKFLKKRRR--GQD------C MLCK__caMLCK VCQHEV-LGGGRFGQVHRCTEKSTGLPLAAKIIKVKSA---KD------- MLCK__SgK085 VSKTEI-LGGGRFGQVHKCEETATGLKLAAKIIKTRGM---KD------- MLCK__skMLCK MNSKEA-LGGGKFGAVCTCMEKATGLKLAAKVIKKQTP---KD------- MLCK__smMLCK YDIEER-LGSGKFGQVFRLVEKKTRKVWAGKFFKAYSA---KE------- MLCK__TTN YMIAED-LGRGEFGIVHRCVETSSKKTYMAKFVKVKG----TD------- Trio__Trio YSEVAE-LGRGRFSVVKKCDQKGTKRAVATKFVNKKL----MK------- Trio__Trad YTELNE-IGRGRFSIVKKCIHKATRKDVAVKFVSKKM----KK------- Trio__SPEG YDIHQE-IGRGAFSYLRRIVERSSGLEFAAKFIPSQA----KP------- Trio__Obscn YEVKEE-IGRGVFGFVKRVQHKGNKILCAAKFIPLRS----RT------- Trio__Domain2_SPEG YTFLEE-KARGRFGVVRACRENATGRTFVAKIVPYAA----EG------- Trio__Domain2_Obscn FAFQTQ-IQRGRFSVVRQCWEKASGRALAAKIIPYHP----KD------- PKD__PKD1 -IFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRF--PT--KQESQ- PKD__PKD3 -IFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRF--PT--KQESQ- PKD__PKD2 -IFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRF--PT--KQESQ- RAD53__CHK2 -YIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKF--AIGSAREADP CAMK1__CaMK1a YDFRDV-LGTGAFSEVILAEDKRTQKLVAIKCIAKEA---LEGK------ CAMK1__CaMK1d FEFKET-LGTGAFSEVVLAEEKATGKLFAVKCIPKKA---LKGK------ CAMK1__CaMK1g FIFMEV-LGSGAFSEVFLVKQRLTGKLFALKCI-KKS---PAFR------ CAMK1__CaMK1b YEIRER-LGSGAFSEVVLAQERGSAHLVALKCIPKKA---LRGK------ CAMK-Unique__VACAMKL YDLGQV-IKTEEFCEIFRAKDKTTGKLHTCKKFQKRD---GRKV------ CAMK1__CaMK4 FEVESE-LGRGATSIVYRCKQKGTQKPYALKVLKKT----VDK------- PSK__PSKH1 YDIKAL-IGRGSFSRVVRVEHRATRQPYAIKMIETKY---REG------- PSK__PSKH2 YDIKAL-IGTGSFSRVVRVEQKTTKKPFAIKVMETRE---REG------- DCAMKL__DCAMKL1 YKVGRT-IGDGNFAVVKECVERSTAREYALKIIKKSK---CRGK------ DCAMKL__DCAMKL2 YKIGKV-IGDGNFAVVKECIDRSTGKEFALKIIDKAK---CCGK------ DCAMKL__DCAMKL3 YETGRV-IGDGNFAVVKECRHRETRQAYAMKIIDKSR---LKGK------ PHK__PHKg1 YEPKEI-LGRGVSSVVRRCIHKPTSQEYAVKVIDVTGGGSFSPEE-VREL PHK__PHKg2 YDPKDV-IGRGVSSVVRRCVHRATGHEFAVKIMEVTAER-LSPEQ-LEEV CAMK2__CaMK2a YQLFEE-LGKGAFSVVRRCVKVLAGQEYAAKIINTKK---LSAR-----D CAMK2__CaMK2d YQLFEE-LGKGAFSVVRRCMKIPTGQGYAAKIINTKK---LSAR-----D CAMK2__CaMK2b YQLYED-IGKGAFSVVRRCVKLCTGHEYAAKIINTKK---LSAR-----D CAMK2__CaMK2g YQLFEE-LGKGAFSVVRRCVKKTSTQEYAAKIINTKK---LSAR-----D CASK__CASK YELCEV-IGKGPFSVVRRCINRETGQQFAVKIVDVAK---FTSSP-G-LS MAPKAPK_MAPKAPK_MAPKAPK2 -KVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQD--------------- MAPKAPK_MAPKAPK_MAPKAPK3 -QLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYD--------------- MAPKAPK_MAPKAPK_MAPKAPK5 -INWTQKLGAGISGPVRVCVKKSTQERFALKILLD--------------- RSKb_MSKb_Domain2_MSK1 -DLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRM------------- RSKb_MSKb_Domain2_MSK2 -------LGQGSFSVCRRCRQRQSGQEFAVKILSRRL------------- RSKb_RSKb_Domain2_RSK2 -YEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDK-S------------- RSKb_RSKb_Domain2_RSK3 -YVVKETIGVGSYSECKRCVHKATNMEYAVKVIDK-S------------- RSKb_RSKb_Domain2_RSK1 -YEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDK-S------------- RSKb_RSKb_Domain2_RSK4 -YELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDK-S------------- Trbl__Trb1 ---------LAEREHVSRALCIHTGRELRCKVFPIK-------------- Trbl__Trb2 ----YLLLEPLEGDHVFRAVHLHSGEELVCKVFDIS-------------- Trbl__Trb3 ------LLEPEEGGRAYQALHCPTGTEYTCKVYPVQ-------------- CAMK-Unique__SgK495 -------------------------------------------------- MAPKAPK_MNK_MNK1 YKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAG----HS------ MAPKAPK_MNK_MNK2 -QLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPG----HI------ CAMKL_AMPK_AMPKa1 VGKIRREIQNLKLFR----HPHIIKLYQVISTPS----------DIFMVM CAMKL_AMPK_AMPKa2 VGKIKREIQNLKLFR----HPHIIKLYQVISTPT----------DFFMVM CAMKL_BRSK_BRSK2 LMKVEREIAILKLIE----HPHVLKLHDVYENKK----------YLYLVL CAMKL_BRSK_BRSK1 LMKVEREIAILKLIE----HPHVLKLHDVYENKK----------YLYLVL CAMKL_MARK_MARK2 LQKLFREVRIMKVLN----HPNIVKLFEVIETEK----------TLYLVM CAMKL_MARK_MARK1 LQKLFREVRIMKILN----HPNIVKLFEVIETEK----------TLYLVM CAMKL_MARK_MARK3 LQKLFREVRIMKILN----HPNIVKLFEVIETQK----------TLYLIM CAMKL_MARK_MARK4 LQKLFREVRIMKGLN----HPNIVKLFEVIETEK----------TLYLVM CAMKL_QIK_QIK LEKIYREVQIMKMLD----HPHIIKLYQVMETKS----------MLYLVT CAMKL_QIK_SIK LEKIYREVQLMKLLN----HPHIIKLYQVMETKD----------MLYIVT CAMKL_QIK_QSK LKKIFREVQIMKMLC----HPHIIRLYQVMETER----------MIYLVT CAMKL_NuaK_NuaK1 MVHIRREIEIMSSLN----HPHIISIYEVFENKD----------KIVIIM CAMKL_NuaK_NuaK2 LMHIRREIEIMSSLN----HPHIIAIHEVFENSS----------KIVIVM CAMKL_HUNK_HUNK TKNLRREGQIQQMIR----HPNITQLLDILETEN----------SYYLVM CAMKL_MELK_MELK LPRIKTEIEALKNLR----HQHICQLYHVLETAN----------KIFMVL CAMKL_NIM1_NIM1 QRLLSREISSMEKLH----HPNIIRLYEVVETLS----------KLHLVM CAMKL_SNRK_SNRK TGHLFQEVRCMKLVQ----HPNIVRLYEVIDTQT----------KLYLIL CAMKL_CHK1_CHK1 -ENIKKEICINKMLN----HENVVKFYG--HRREGN--------IQYLFL CAMKL_LKB_LKB1 EANVKKEIQLLRRLR----HKNVIQLVDVLYNEEKQ--------KMYMVM TSSK__SSTK -KFLPRELSILRGVR----HPHIVHVFEFIEVCNG---------KLYIVM TSSK__TSSK3 -RFLPRELQIVRTLD----HKNIIQVYEMLESADG---------KICLVM TSSK__TSSK2 -RFLPREMDILATVN----HGSIIKTYEIFETSDG---------RIYIIM TSSK__TSSK1 -KFLPREIEILAMLN----HCSIIKTYEIFETSHG---------KVYIVM TSSK__TSSK4 -KFLPREIQVMKVLR----HKYLINFYRAIESTS----------RVYIIL PIM__PIM3 GATVPLEVVLLRKVGAAGGARGVIRLLDWFERPD----------GFLLVL PIM__PIM1 GTRVPMEVVLLKKV--SSGFSGVIRLLDWFERPD----------SFVLIL PIM__PIM2 SVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQE----------GFMLVL CAMKL_PASK_PASK LGKVTLEIAILSRV----EHANIIKVLDIFENQG----------FFQLVM CAMK-Unique__STK33 VKLLEREVNILKSVK----HEHIIHLEQVFETPK----------KMYLVM DAPK__DAPK1 REDIEREVSILKEIQ----HPNVITLHEVYENKT----------DVILIL DAPK__DAPK3 REEIEREVNILREIR----HPNIITLHDIFENKT----------DVVLIL DAPK__DAPK2 REEIEREVSILRQVL----HHNVITLHDVYENRT----------DVVLIL DAPK__DRAK1 RMEIIHEIAVLELAQD---NPWVINLHEVYETAS----------EMILVL DAPK__DRAK2 RAEILHEIAVLELAKS---CPRVINLHEVYENTS----------EIILIL MLCK__caMLCK REDVKNEINIMNQLS----HVNLIQLYDAFESKH----------SCTLVM MLCK__SgK085 KEEVKNEISVMNQLD----HANLIQLYDAFESKN----------DIVLVM MLCK__skMLCK KEMVLLEIEVMNQLN----HRNLIQLYAAIETPH----------EIVLFM MLCK__smMLCK KENIRQEISIMNCLH----HPKLVQCVDAFEEKA----------NIVMVL MLCK__TTN QVLVKKEISILNIAR----HRNILHLHESFESME----------ELVMIF Trio__Trio RDQVTHELGILQSLQ----HPLLVGLLDTFETPT----------SYILVL Trio__Trad KEQAAHEAALLQHLQ----HPQYITLHDTYESPT----------SYILIL Trio__SPEG KASARREARLLARLQ----HDCVLYFHEAFERRR----------GLVIVT Trio__Obscn RAQAYRERDILAALS----HPLVTGLLDQFETRK----------TLILIL Trio__Domain2_SPEG KRRVLQEYEVLRTLH----HERIMSLHEAYITPR----------YLVLIA Trio__Domain2_Obscn KTAVLREYEALKGLR----HPHLAQLHAAYLSPR----------HLVLIL PKD__PKD1 ---LRNEVAILQNLH----HPGVVNLECMFETPER----------VFVVM PKD__PKD3 ---LRNEVAILQNLH----HPGIVNLECMFETPER----------VFVVM PKD__PKD2 ---LRNEVAILQSLR----HPGIVNLECMFETPEK----------VFVVM RAD53__CHK2 ALNVETEIEILKKLN----HPCIIKIKNFFDA-ED----------YYIVL CAMK1__CaMK1a EGSMENEIAVLHKIK----HPNIVALDDIYESGG----------HLYLIM CAMK1__CaMK1d ESSIENEIAVLRKIK----HENIVALEDIYESPN----------HLYLVM CAMK1__CaMK1g DSSLENEIAVLKKIK----HENIVTLEDIYESTT----------HYYLVM CAMK1__CaMK1b EALVENEIAVLRRIS----HPNIVALEDVHESPS----------HLYLAM CAMK-Unique__VACAMKL RKAAKNEIGILKMVK----HPNILQLVDVFVTRK----------EYFIFL CAMK1__CaMK4 -KIVRTEIGVLLRLS----HPNIIKLKEIFETPT----------EISLVL PSK__PSKH1 REVCESELRVLRRVR----HANIIQLVEVFETQE----------RVYMVM PSK__PSKH2 REACVSELSVLRRVS----HRYIVQLMEIFETED----------QVYMVM DCAMKL__DCAMKL1 EHMIQNEVSILRRVK----HPNIVLLIEEMDVPT----------ELYLVM DCAMKL__DCAMKL2 EHLIENEVSILRRVK----HPNIIMLVEEMETAT----------ELFLVM DCAMKL__DCAMKL3 EDMVDSEILIIQSLS----HPNIVKLHEVYETDM----------EIYLIL PHK__PHKg1 REATLKEVDILRKVSG---HPNIIQLKDTYETNT----------FFFLVF PHK__PHKg2 REATRRETHILRQVAG---HPHIITLIDSYESSS----------FMFLVF CAMK2__CaMK2a HQKLEREARICRLLK----HPNIVRLHDSISEEG----------HHYLIF CAMK2__CaMK2d HQKLEREARICRLLK----HPNIVRLHDSISEEG----------FHYLVF CAMK2__CaMK2b HQKLEREARICRLLK----HSNIVRLHDSISEEG----------FHYLVF CAMK2__CaMK2g HQKLEREARICRLLK----HPNIVRLHDSISEEG----------FHYLVF CASK__CASK TEDLKREASICHMLK----HPHIVELLETYSSDG----------MLYMVF MAPKAPK_MAPKAPK_MAPKAPK2 CPKARREVELHWRASQ---CPHIVRIVDVYEN------LYAGRKCLLIVM MAPKAPK_MAPKAPK_MAPKAPK3 SPKARQEVDHHWQASG---GPHIVCILDVYEN------MHHGKRCLLIIM MAPKAPK_MAPKAPK_MAPKAPK5 RPKARNEVRLHMMCAT---HPNIVQIIEVFANSVQFPHESSPRARLLIVM RSKb_MSKb_Domain2_MSK1 EANTQKEITALKLCEG---HPNIVKLHEVFHD----------QLHTFLVM RSKb_MSKb_Domain2_MSK2 EANTQREVAALRLCQS---HPNVVNLHEVHHD----------QLHTYLVL RSKb_RSKb_Domain2_RSK2 KRDPTEEIEILLRYGQ---HPNIITLKDVYDD----------GKYVYVVT RSKb_RSKb_Domain2_RSK3 KRDPSEEIEILLRYGQ---HPNIITLKDVYDD----------GKHVYLVT RSKb_RSKb_Domain2_RSK1 KRDPSEEIEILLRYGQ---HPNIITLKDVYDD----------GKFVYLVM RSKb_RSKb_Domain2_RSK4 KRDPSEEIEILMRYGQ---HPNIITLKDVFDD----------GRYVYLVT Trbl__Trb1 --HYQDKIRPYIQLPS---HSNITGIVEVILGET----------KAYVFF Trbl__Trb2 --CYQESLAPCFCLSA---HSNINQITEIILGET----------KAYVFF Trbl__Trb3 --EALAVLEPYARLPP---HKHVARPTEVLAGTQ----------LLYAFF CAMK-Unique__SgK495 -------------------------------------------------- MAPKAPK_MNK_MNK1 RSRVFREVETLYQCQG---NKNILELIEFFEDDT----------RFYLVF MAPKAPK_MNK_MNK2 RSRVFREVEMLYQCQG---HRNVLELIEFFEEED----------RFYLVF CAMKL_AMPK_AMPKa1 EYVSGG--ELFDYIC-K---NGRLDEKESRRLFQQILSGVDYCHRHM-VV CAMKL_AMPK_AMPKa2 EYVSGG--ELFDYIC-K---HGRVEEMEARRLFQQILSAVDYCHRHM-VV CAMKL_BRSK_BRSK2 EHVSGG--ELFDYLV-K---KGRLTPKEARKFFRQIISALDFCHSHS-IC CAMKL_BRSK_BRSK1 EHVSGG--ELFDYLV-K---KGRLTPKEARKFFRQIVSALDFCHSYS-IC CAMKL_MARK_MARK2 EYASGG--EVFDYLV-A---HGRMKEKEARAKFRQIVSAVQYCHQKF-IV CAMKL_MARK_MARK1 EYASGG--EVFDYLV-A---HGRMKEKEARAKFRQIVSAVQYCHQKY-IV CAMKL_MARK_MARK3 EYASGG--KVFDYLV-A---HGRMKEKEARSKFRQIVSAVQYCHQKR-IV CAMKL_MARK_MARK4 EYASAG--EVFDYLV-S---HGRMKEKEARAKFRQIVSAVHYCHQKN-IV CAMKL_QIK_QIK EYAKNG--EIFDYLA-N---HGRLNESEARRKFWQILSAVDYCHGRK-IV CAMKL_QIK_SIK EFAKNG--EMFDYLT-S---NGHLSENEARKKFWQILSAVEYCHDHH-IV CAMKL_QIK_QSK EYASGG--EIFDHLV-A---HGRMAEKEARRKFKQIVTAVYFCHCRN-IV CAMKL_NuaK_NuaK1 EYASKG--ELYDYIS-E---RRRLSERETRHFFRQIVSAVHYCHKNG-VV CAMKL_NuaK_NuaK2 EYASRG--DLYDYIS-E---RQQLSEREARHFFRQIVSAVHYCHQNR-VV CAMKL_HUNK_HUNK ELCPGG--NLMHKIY-E---KKRLEESEARRYIRQLISAVEHLHRAG-VV CAMKL_MELK_MELK EYCPGG--ELFDYII-S---QDRLSEEETRVVFRQIVSAVAYVHSQG-YA CAMKL_NIM1_NIM1 EYAGGG--ELFGKIS-T---EGKLSEPESKLIFSQIVSAVKHMHENQ-II CAMKL_SNRK_SNRK ELGDGG--DMFDYIMKH---EEGLNEDLAKKYFAQIVHAISYCHKLH-VV CAMKL_CHK1_CHK1 EYCSG--GELFDRIE-P---DIGMPEPDAQRFFHQLMAGVVYLHGIG-IT CAMKL_LKB_LKB1 EYCVCGMQEMLDSVP-----EKRFPVCQAHGYFCQLIDGLEYLHSQG-IV TSSK__SSTK EAAAT---DLLQAVQ-R---NGRIPGVQARDLFAQIAGAVRYLHDHH-LV TSSK__TSSK3 ELAEGG--DVFDCVL-N---GGPLPESRAKALFRQMVEAIRYCHGCG-VA TSSK__TSSK2 ELGVQG--DLLEFIK-C---QGALHEDVARKMFRQLSSAVKYCHDLD-IV TSSK__TSSK1 ELAVQG--DLLELIK-T---RGALHEDEARKKFHQLSLAIKYCHDLD-VV TSSK__TSSK4 ELAQGG--DVLEWIQ-R---YGACSEPLAGKWFSQLTLGIAYLHSKS-IV PIM__PIM3 ERPEPA-QDLFDFIT-E---RGALDEPLARRFFAQVLAAVRHCHSCG-VV PIM__PIM1 ERPEPV-QDLFDFIT-E---RGALQEELARSFFWQVLEAVRHCHNCG-VL PIM__PIM2 ERPLPA-QDLFDYIT-E---KGPLGEGPSRCFFGQVVAAIQHCHSRG-VV CAMKL_PASK_PASK EKHGSG-LDLFAFID-R---HPRLDEPLASYIFRQLVSAVGYLRLKD-II CAMK-Unique__STK33 ELCEDG--ELKEILD-R---KGHFSENETRWIIQSLASAIAYLHNND-IV DAPK__DAPK1 ELVAGG--ELFDFLAEK----ESLTEEEATEFLKQILNGVYYLHSLQ-IA DAPK__DAPK3 ELVSGG--ELFDFLAEK----ESLTEDEATQFLKQILDGVHYLHSKR-IA DAPK__DAPK2 ELVSGG--ELFDFLAQK----ESLSEEEATSFIKQILDGVNYLHTKK-IA DAPK__DRAK1 EYAAGG--EIFDQCVADR--EEAFKEKDVQRLMRQILEGVHFLHTRD-VV DAPK__DRAK2 EYAAGG--EIFSLCLPEL--AEMVSENDVIRLIKQILEGVYYLHQNN-IV MLCK__caMLCK EYVDGG--ELFDRITDEK---YHLTELDVVLFTRQICEGVHYLHQHY-IL MLCK__SgK085 EYVDGG--ELFDRIIDES---YNLTELDTILFMKQICEGIRHMHQMY-IL MLCK__skMLCK EYIEGG--ELFERIVDED---YHLTEVDTMVFVRQICDGILFMHKMR-VL MLCK__smMLCK EIVSGG--ELFERIIDED---FELTERECIKYMRQISEGVEYIHKQG-IV MLCK__TTN EFISGL--DIFERINTSA---FELNEREIVSYVHQVCEALQFLHSHN-IG Trio__Trio EMADQG--RLLDCVVRWG----SLTEGKIRAHLGEVLEAVRYLHNCR-IA Trio__Trad ELMDDG--RLLDYLMNHD----ELMEEKVAFYIRDIMEALQYLHNCR-VA Trio__SPEG ELCT-E--ELLERIARKP----TVCESEIRAYMRQVLEGIHYLHQSH-VL Trio__Obscn ELCSSE--ELLDRLYRKG----VVTEAEVKVYIQQLVEGLHYLHSHG-VL Trio__Domain2_SPEG ESCGNR--ELLCGLSDRF----RYSEDDVATYMVQLLQGLDYLHGHH-VL Trio__Domain2_Obscn ELCSGP--ELLPCLAERA----SYSESEVKDYLWQMLSATQYLHNQH-IL PKD__PKD1 EKLHG---DMLEMILSSE--KGRLPEHITKFLITQILVALRHLHFKN-IV PKD__PKD3 EKLHG---DMLEMILSSE--KSRLPERITKFMVTQILVALRNLHFKN-IV PKD__PKD2 EKLHG---DMLEMILSSE--KGRLPERLTKFLITQILVALRHLHFKN-IV RAD53__CHK2 ELMEGG--ELFDKVVGNK----RLKEATCKLYFYQMLLAVQYLHENG-II CAMK1__CaMK1a QLVSGG--ELFDRIVEKG----FYTERDASRLIFQVLDAVKYLHDLG-IV CAMK1__CaMK1d QLVSGG--ELFDRIVEKG----FYTEKDASTLIRQVLDAVYYLHRMG-IV CAMK1__CaMK1g QLVSGG--ELFDRILERG----VYTEKDASLVIQQVLSAVKYLHENG-IV CAMK1__CaMK1b ELVTGG--ELFDRIMERG----SYTEKDASHLVGQVLGAVSYLHSLG-IV CAMK-Unique__VACAMKL ELATGR--EVFDWILDQG----YYSERDTSNVVRQVLEAVAYLHSLK-IV CAMK1__CaMK4 ELVTGG--ELFDRIVEKG----YYSERDAADAVKQILEAVAYLHENG-IV PSK__PSKH1 ELATGG--ELFDRIIAKG----SFTERDATRVLQMVLDGVRYLHALG-IT PSK__PSKH2 ELATGG--ELFDRLIAQG----SFTERDAVRILQMVADGIRYLHALQ-IT DCAMKL__DCAMKL1 ELVKGG--DLFDAITSTN----KYTERDASGMLYNLASAIKYLHSLN-IV DCAMKL__DCAMKL2 ELVKGG--DLFDAITSST----KYTERDGSAMVYNLANALRYLHGLS-IV DCAMKL__DCAMKL3 EYVQGG--DLFDAIIESV----KFPEPDAALMIMDLCKALVHMHDKS-IV PHK__PHKg1 DLMKRG--ELFDYLTEKV----TLSEKETRKIMRALLEVICTLHKLN-IV PHK__PHKg2 DLMRKG--ELFDYLTEKV----ALSEKETRSIMRSLLEAVSFLHANN-IV CAMK2__CaMK2a DLVTGG--ELFEDIVARE----YYSEADASHCIQQILEAVLHCHQMG-VV CAMK2__CaMK2d DLVTGG--ELFEDIVARE----YYSEADASHCIQQILESVNHCHLNG-IV CAMK2__CaMK2b DLVTGG--ELFEDIVARE----YYSEADASHCIQQILEAVLHCHQMG-VV CAMK2__CaMK2g DLVTGG--ELFEDIVARE----YYSEADASHCIHQILESVNHIHQHD-IV CASK__CASK EFMDGA--DLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNN-II MAPKAPK_MAPKAPK_MAPKAPK2 ECLDGG--ELFSRIQDRG--DQAFTEREASEIMKSIGEAIQYLHSIN-IA MAPKAPK_MAPKAPK_MAPKAPK3 ECMEGG--ELFSRIQERG--DQAFTEREAAEIMRDIGTAIQFLHSHN-IA MAPKAPK_MAPKAPK_MAPKAPK5 EMMEGG--ELFHRISQH----RHFTEKQASQVTKQIALALRHCHLLN-IA RSKb_MSKb_Domain2_MSK1 ELLNGG--ELFERIKKK----KHFSETEASYIMRKLVSAVSHMHDVG-VV RSKb_MSKb_Domain2_MSK2 ELLRGG--ELLEHIRKK----RHFSESEASQILRSLVSAVSFMHEEAGVV RSKb_RSKb_Domain2_RSK2 ELMKGG--ELLDKILRQ----KFFSEREASAVLFTITKTVEYLHAQG-VV RSKb_RSKb_Domain2_RSK3 ELMRGG--ELLDKILRQ----KFFSEREASFVLHTIGKTVEYLHSQG-VV RSKb_RSKb_Domain2_RSK1 ELMRGG--ELLDRILRQ----RYFSEREASDVLCTITKTMDYLHSQG-VV RSKb_RSKb_Domain2_RSK4 DLMKGG--ELLDRILKQ----KCFSEREASDILYVISKTVDYLHCQG-VV Trbl__Trb1 EKDFG---DMHSYVRSR----KRLREEEAARLFKQIVSAVAHCHQSA-IV Trbl__Trb2 ERSYG---DMHSFVRTC----KKLREEEAARLFYQIASAVAHCHDGG-LV Trbl__Trb3 TRTHG---DMHSLVRSR----HRIPEPEAAVLFRQMATALAHCHQHG-LV CAMK-Unique__SgK495 --------NLQHYVIKE----KRLSERETVVIFYDVVRVVEALHQKN-IV MAPKAPK_MNK_MNK1 EKLQGG--SILAHIQKQ----KHFNEREASRVVRDVAAALDFLHTKG-IA MAPKAPK_MNK_MNK2 EKMRGG--SILSHIHKR----RHFNELEASVVVQDVASALDFLHNKG-IA : : : CAMKL_AMPK_AMPKa1 HRDLKPEN-VLLDAH--------MN-AKIADFGLS--------------- CAMKL_AMPK_AMPKa2 HRDLKPEN-VLLDAH--------MN-AKIADFGLS--------------- CAMKL_BRSK_BRSK2 HRDLKPEN-LLLDEK--------NN-IRIADFGMA--------------- CAMKL_BRSK_BRSK1 HRDLKPEN-LLLDEK--------NN-IRIADFGMA--------------- CAMKL_MARK_MARK2 HRDLKAEN-LLLDAD--------MN-IKIADFGFS--------------- CAMKL_MARK_MARK1 HRDLKAEN-LLLDGD--------MN-IKIADFGFS--------------- CAMKL_MARK_MARK3 HRDLKAEN-LLLDAD--------MN-IKIADFGFS--------------- CAMKL_MARK_MARK4 HRDLQAEN-LLLDAE--------AN-IKIADFGFS--------------- CAMKL_QIK_QIK HRDLKAEN-LLLDNN--------MN-IKIADFGFG--------------- CAMKL_QIK_SIK HRDLKTEN-LLLDGN--------MD-IKLADFGFG--------------- CAMKL_QIK_QSK HRDLKAEN-LLLDAN--------LN-IKIADFGFS--------------- CAMKL_NuaK_NuaK1 HRDLKLEN-ILLDDN--------CN-IKIADFGLS--------------- CAMKL_NuaK_NuaK2 HRDLKLEN-ILLDAN--------GN-IKIADFGLS--------------- CAMKL_HUNK_HUNK HRDLKIEN-LLLDED--------NN-IKLIDFGLSNCA------------ CAMKL_MELK_MELK HRDLKPEN-LLFDEY--------HK-LKLIDFGL--CA------------ CAMKL_NIM1_NIM1 HRDLKAEN-VFYTSN--------TC-VKVGDFGFS--------------- CAMKL_SNRK_SNRK HRDLKPENVVFFEKQ--------GL-VKLTDFGFS--------------- CAMKL_CHK1_CHK1 HRDIKPEN-LLLDER--------DN-LKISDFGLATVF------------ CAMKL_LKB_LKB1 HKDIKPGN-LLLTTG--------GT-LKISDLGVAEAL------------ TSSK__SSTK HRDLKCEN-VLLSPDE-------RR-VKLTDFGFGR-------------- TSSK__TSSK3 HRDLKCEN-ALLQG---------FN-LKLTDFGFAKV------------- TSSK__TSSK2 HRDLKCEN-LLLDKD--------FN-IKLSDFGFSKRC-----------L TSSK__TSSK1 HRDLKCDN-LLLDKD--------FN-IKLSDFSFSKRC-----------L TSSK__TSSK4 HRDLKLEN-LLLDK-W-------EN-VKISDFGFAKMVPSNQPVGCSPSY PIM__PIM3 HRDIKDEN-LLVDLRS-------GE-LKLIDFGSG--------------- PIM__PIM1 HRDIKDEN-ILIDLNR-------GE-LKLIDFGSG--------------- PIM__PIM2 HRDIKDEN-ILIDLRR-------GC-AKLIDFGSG--------------- CAMKL_PASK_PASK HRDIKDEN-IVIAEDF-------T--IKLIDFGSA--------------- CAMK-Unique__STK33 HRDLKLENIMVKSSLIDDNNEINLN-IKVTDFGLAVK------------- DAPK__DAPK1 HFDLKPENIMLLDRNV-----PKPR-IKIIDFGLAH-------------- DAPK__DAPK3 HFDLKPENIMLLDKNV-----PNPR-IKLIDFGIAH-------------- DAPK__DAPK2 HFDLKPENIMLLDKNI-----PIPH-IKLIDFGLAH-------------- DAPK__DRAK1 HLDLKPQNILLTSE-S-----PLGD-IKIVDFGLSR-------------- DAPK__DRAK2 HLDLKPQNILLSSI-Y-----PLGD-IKIVDFGMSR-------------- MLCK__caMLCK HLDLKPENILCVNQ-------TGHQ-IKIIDFGLAR-------------- MLCK__SgK085 HLDLKPENILCVNR-------DAKQ-IKIIDFGLAR-------------- MLCK__skMLCK HLDLKPENILCVNT-------TGHL-VKIIDFGLAR-------------- MLCK__smMLCK HLDLKPENIMCVNK-------TGTR-IKLIDFGLAR-------------- MLCK__TTN HFDIRPENIIYQTR-------RSST-IKIIEFGQAR-------------- Trio__Trio HLDLKPENILVDESLA-----KP-T-IKLADFGDAV-------------- Trio__Trad HLDIKPENLLIDLRIP-----VP-R-VKLIDLEDAV-------------- Trio__SPEG HLDVKPENLLVWDGAA-----GEQQ-VRICDFGNAQ-------------- Trio__Obscn HLDIKPSNILMVHPAR-------ED-IKICDFGFAQ-------------- Trio__Domain2_SPEG HLDIKPDNLLLAPDNA----------LKIVDFGSAQ-------------- Trio__Domain2_Obscn HLDLRSENMIITEYNL----------LKVVDLGNAQ-------------- PKD__PKD1 HCDLKPENVLLASADP------FPQ-VKLCDFGFAR-------------- PKD__PKD3 HCDLKPENVLLASAEP------FPQ-VKLCDFGFAR-------------- PKD__PKD2 HCDLKPENVLLASADP------FPQ-VKLCDFGFAR-------------- RAD53__CHK2 HRDLKPENVLLSSQEE------DCL-IKITDFGHSK-------------- CAMK1__CaMK1a HRDLKPENLLYYSLDED------SK-IMISDFGLSKM------------- CAMK1__CaMK1d HRDLKPENLLYYSQDEE------SK-IMISDFGLSKM------------- CAMK1__CaMK1g HRDLKPENLLYLTPEEN------SK-IMITDFGLSKM------------- CAMK1__CaMK1b HRDLKPENLLYATPFED------SK-IMVSDFGLSKI------------- CAMK-Unique__VACAMKL HRNLKLENLVYYNRLKN------SK-IVISDFHLAKL------------- CAMK1__CaMK4 HRDLKPENLLYATPAPD------AP-LKIADFGLSKI------------- PSK__PSKH1 HRDLKPENLLYYHPGTD------SK-IIITDFGLASA------------- PSK__PSKH2 HRNLKPENLLYYHPGEE------SK-ILITDFGLAYS------------- DCAMKL__DCAMKL1 HRDIKPENLLVYEHQDG------SKSLKLGDFGLATI------------- DCAMKL__DCAMKL2 HRDIKPENLLVCEYPDG------TKSLKLGDFGLATV------------- DCAMKL__DCAMKL3 HRDLKPENLLVQRNEDK------STTLKLADFGLAKH------------- PHK__PHKg1 HRDLKPENILLDDNMN----------IKLTDFGFSCQ------------- PHK__PHKg2 HRDLKPENILLDDNMQ----------IRLSDFGFSCH------------- CAMK2__CaMK2a HRDLKPENLLLASKLKG------AA-VKLADFGLAIE------------- CAMK2__CaMK2d HRDLKPENLLLASKSKG------AA-VKLADFGLAIE------------- CAMK2__CaMK2b HRDLKPENLLLASKCKG------AA-VKLADFGLAIE------------- CAMK2__CaMK2g HRDLKPENLLLASKCKG------AA-VKLADFGLAIE------------- CASK__CASK HRDVKPHCVLLASKENS------AP-VKLGGFGVAIQ------------- MAPKAPK_MAPKAPK_MAPKAPK2 HRDVKPENLLYTSKRPN------AI-LKLTDFGFAK-------------- MAPKAPK_MAPKAPK_MAPKAPK3 HRDVKPENLLYTSKEKD------AV-LKLTDFGFAK-------------- MAPKAPK_MAPKAPK_MAPKAPK5 HRDLKPENLLFKDNSLD------AP-VKLCDFGFAK-------------- RSKb_MSKb_Domain2_MSK1 HRDLKPENLLFTDENDN------LE-IKIIDFGFAR-------------- RSKb_MSKb_Domain2_MSK2 HRDLKPENILYADDTPG------AP-VKIIDFGFAR-------------- RSKb_RSKb_Domain2_RSK2 HRDLKPSNILYVDESGN------PESIRICDFGFAK-------------- RSKb_RSKb_Domain2_RSK3 HRDLKPSNILYVDESGN------PECLRICDFGFAK-------------- RSKb_RSKb_Domain2_RSK1 HRDLKPSNILYRDESGS------PESIRVCDFGFAK-------------- RSKb_RSKb_Domain2_RSK4 HRDLKPSNILYMDESAS------ADSIRICDFGFAK-------------- Trbl__Trb1 LGDLKLRKFVFST--EE------RTQLRLESLEDTH-------------- Trbl__Trb2 LRDLKLRKFIFKD--EE------RTRVKLESLEDAY-------------- Trbl__Trb3 LRDLKLCRFVFAD--RE------RKKLVLENLEDSC-------------- CAMK-Unique__SgK495 HRDLKLGNMVLN---KR------THRITITNFCLGK-------------- MAPKAPK_MNK_MNK1 HRDLKPENILCESP-EK------VSPVKICDFDLGS-------------- MAPKAPK_MNK_MNK2 HRDLKPENILCEHP-NQ------VSPVKICDFDLGS-------------- ::: : : CAMKL_AMPK_AMPKa1 NMMSDG-EF-------LRTSCGSPNYAAPEVIS-G--------------- CAMKL_AMPK_AMPKa2 NMMSDG-EF-------LRTSCGSPNYTAPEVIS-G--------------- CAMKL_BRSK_BRSK2 SLQVGD-SL-------LETSCGSPHYACPEVIR-G--------------- CAMKL_BRSK_BRSK1 SLQVGD-SL-------LETSCGSPHYACPEVIK-G--------------- CAMKL_MARK_MARK2 NEFTFG-NK-------LDTFCGSPPYAAPELFQ-G--------------- CAMKL_MARK_MARK1 NEFTVG-NK-------LDTFCGSPPYAAPELFQ-G--------------- CAMKL_MARK_MARK3 NEFTVG-GK-------LDTFCGSPPYAAPELFQ-G--------------- CAMKL_MARK_MARK4 NEFTLG-SK-------LDTFCGSPPYAAPELFQ-G--------------- CAMKL_QIK_QIK NFFKSG-EL-------LATWCGSPPYAAPEVFE-G--------------- CAMKL_QIK_SIK NFYKSG-EP-------LSTWCGSPPYAAPEVFE-G--------------- CAMKL_QIK_QSK NLFTPG-QL-------LKTWCGSPPYAAPELFE-G--------------- CAMKL_NuaK_NuaK1 NLYQKD-KF-------LQTFCGSPLYASPEIVN-G--------------- CAMKL_NuaK_NuaK2 NLYHQG-KF-------LQTFCGSPLYASPEIVN-G--------------- CAMKL_HUNK_HUNK GILGYS-DP-------FSTQCGSPAYAAPELLA-R--------------- CAMKL_MELK_MELK KPKGNK-DYH------LQTCCGSLAYAAPELIQ-G--------------- CAMKL_NIM1_NIM1 TVSKKG-EM-------LNTFCGSPPYAAPELFR-D--------------- CAMKL_SNRK_SNRK NKFQPG-KK-------LTTSCGSLAYSAPEILL-G--------------- CAMKL_CHK1_CHK1 -RYNNR-ERL------LNKMCGTLPYVAPELLK-R--------------- CAMKL_LKB_LKB1 -HPFAA-DDT------CRTSQGSPAFQPPEIANGL--------------- TSSK__SSTK -QAHGY-PDL------STTYCGSAAYASPEVLL-G--------------- TSSK__TSSK3 -LPKSH-REL------SQTFCGSTAYAAPEVLQ-G--------------- TSSK__TSSK2 RDSNGR-IIL------SKTFCGSAAYAAPEVLQ-S--------------- TSSK__TSSK1 RDDSGR-MAL------SKTFCGSPAYAAPEVLQ-G--------------- TSSK__TSSK4 RQVNCF-SHL------SQTYCGSFAYACPEILR-G--------------- PIM__PIM3 -ALLK--DTV------YTDFDGTRVYSPPEWIR-Y--------------- PIM__PIM1 -ALLK--DTV------YTDFDGTRVYSPPEWIR-Y--------------- PIM__PIM2 -ALLH--DEP------YTDFDGTRVYSPPEWIS-R--------------- CAMKL_PASK_PASK -AYLER-GKL------FYTFCGTIEYCAPEVLM-G--------------- CAMK-Unique__STK33 -KQSRS-EAM------LQATCGTPIYMAPEVIS-A--------------- DAPK__DAPK1 -KIDFG--NE------FKNIFGTPEFVAPEIVN----------------- DAPK__DAPK3 -KIEAG--NE------FKNIFGTPEFVAPEIVN----------------- DAPK__DAPK2 -EIEDG--VE------FKNIFGTPEFVAPEIVN----------------- DAPK__DRAK1 -ILKNS--EE------LREIMGTPEYVAPEILS----------------- DAPK__DRAK2 -KIGHA--CE------LREIMGTPEYLAPEILN----------------- MLCK__caMLCK -RYKPR--EK------LKVNFGTPEFLAPEVVN----------------- MLCK__SgK085 -RYKPR--EK------LKVNFGTPEFLAPEVVN----------------- MLCK__skMLCK -RYNPN--EK------LKVNFGTPEFLSPEVVN----------------- MLCK__smMLCK -RLENA--GS------LKVLFGTPEFVAPEVIN----------------- MLCK__TTN -QLKPG--DN------FRLLFTAPEYYAPEVHQ----------------- Trio__Trio -QLNTT--YY------IHQLLGNPEFAAPEIIL----------------- Trio__Trad -QISGH--FH------IHHLLGNPEFAAPEVIQ----------------- Trio__SPEG -ELTPG--EP------QYCQYGTPEFVAPEIVN----------------- Trio__Obscn -NITPA--EL------QFSQYGSPEFVSPEIIQ----------------- Trio__Domain2_SPEG -PYNPQALRP------LGHRTGTLEFMAPEMVK----------------- Trio__Domain2_Obscn -SLSQEKVLP------SDKFKDYLETMAPELLE----------------- PKD__PKD1 -IIGEK--SF------RRSVVGTPAYLAPEVLRNK--------------- PKD__PKD3 -IIGEK--SF------RRSVVGTPAYLAPEVLRSK--------------- PKD__PKD2 -IIGEK--SF------RRSVVGTPAYLAPEVLLNQ--------------- RAD53__CHK2 -ILGET--SL------MRTLCGTPTYLAPEVLVSVG-------------- CAMK1__CaMK1a --EDPGS--V------LSTACGTPGYVAPEVLAQ---------------- CAMK1__CaMK1d --EGKGD--V------MSTACGTPGYVAPEVLAQ---------------- CAMK1__CaMK1g --EQNG---I------MSTACGTPGYVAPEVLAQ---------------- CAMK1__CaMK1b --QAGN---M------LGTACGTPGYVAPELLEQ---------------- CAMK-Unique__VACAMKL --ENG----L------IKEPCGTP-----EYLGN---------------- CAMK1__CaMK4 --VEHQV--L------MKTVCGTPGYCAPEILRG---------------- PSK__PSKH1 --RKKGDDCL------MKTTCGTPEYIAPEVLVR---------------- PSK__PSKH2 --GKKSGDWT------MKTLCGTPEYIAPEVLLR---------------- DCAMKL__DCAMKL1 --VDG----P------LYTVCGTPTYVAPEIIAE---------------- DCAMKL__DCAMKL2 --VEG----P------LYTVCGTPTYVAPEIIAE---------------- DCAMKL__DCAMKL3 --VVR----P------IFTVCGTPTYVAPEILSE---------------- PHK__PHKg1 --LE--PGER------LREVCGTPSYLAPEIIECSMNED----------- PHK__PHKg2 --LE--PGEK------LRELCGTPGYLAPEILKCSMDET----------- CAMK2__CaMK2a --VEG-EQQA------WFGFAGTPGYLSPEVLRK---------------- CAMK2__CaMK2d --VQG-DQQA------WFGFAGTPGYLSPEVLRK---------------- CAMK2__CaMK2b --VQG-DQQA------WFGFAGTPGYLSPEVLRK---------------- CAMK2__CaMK2g --VQG-EQQA------WFGFAGTPGYLSPEVLRK---------------- CASK__CASK --LGE-SGLV------AGGRVGTPHFMAPEVVKR---------------- MAPKAPK_MAPKAPK_MAPKAPK2 -ETTSH--NS------LTTPCYTPYYVAPEVLGPEK-------------- MAPKAPK_MAPKAPK_MAPKAPK3 -ETT-Q--NA------LQTPCYTPYYVAPEVLGPEK-------------- MAPKAPK_MAPKAPK_MAPKAPK5 -IDQ----GD------LMTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSP RSKb_MSKb_Domain2_MSK1 -LKPPD-NQP------LKTPCFTLHYAAPELLNQNG-------------- RSKb_MSKb_Domain2_MSK2 -LRPQSPGVP------MQTPCFTLQYAAPELLAQQG-------------- RSKb_RSKb_Domain2_RSK2 -QLRAE-NGL------LMTPCYTANFVAPEVLKRQG-------------- RSKb_RSKb_Domain2_RSK3 -QLRAE-NGL------LMTPCYTANFVAPEVLKRQG-------------- RSKb_RSKb_Domain2_RSK1 -QLRAG-NGL------LMTPCYTANFVAPEVLKRQG-------------- RSKb_RSKb_Domain2_RSK4 -QLRGE-NGL------LLTPCYTANFVAPEVLMQQG-------------- Trbl__Trb1 -IMKGEDDA-------LSDKHGCPAYVSPEILNTTG-------------- Trbl__Trb2 -ILRGDDDS-------LSDKHGCPAYVSPEILNTSG-------------- Trbl__Trb3 -VLTGPDDS-------LWDKHACPAYVGPEILSSRA-------------- CAMK-Unique__SgK495 -HLVSEGDL-------LKDQRGSPAYISPDVLSGR--------------- MAPKAPK_MNK_MNK1 -GMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQ------------ MAPKAPK_MNK_MNK2 -GIKLNGDCSPISTPELLTPCGSAEYMAPELVEAFSEE------------ : CAMKL_AMPK_AMPKa1 -RLYAGPEVDIWSSGVILYALLCGTLPFDDD---------------HVPT CAMKL_AMPK_AMPKa2 -RLYAGPEVDIWSCGVILYALLCGTLPFDDE---------------HVPT CAMKL_BRSK_BRSK2 -EKYDGRKADVWSCGVILFALLVGALPFDDD---------------NLRQ CAMKL_BRSK_BRSK1 -EKYDGRRADMWSCGVILFALLVGALPFDDD---------------NLRQ CAMKL_MARK_MARK2 -KKYDGPEVDVWSLGVILYTLVSGSLPFDGQ---------------NLKE CAMKL_MARK_MARK1 -KKYDGPEVDVWSLGVILYTLVSGSLPFDGQ---------------NLKE CAMKL_MARK_MARK3 -KKYDGPEVDVWSLGVILYTLVSGSLPFDGQ---------------NLKE CAMKL_MARK_MARK4 -KKYDGPEVDIWSLGVILYTLVSGSLPFDGH---------------NLKE CAMKL_QIK_QIK -QQYEGPQLDIWSMGVVLYVLVCGALPFDGP---------------TLPI CAMKL_QIK_SIK -KEYEGPQLDIWSLGVVLYVLVCGSLPFDGP---------------NLPT CAMKL_QIK_QSK -KEYDGPKVDIWSLGVVLYVLVCGALPFDGS---------------TLQN CAMKL_NuaK_NuaK1 -RPYRGPEVDSWALGVLLYTLVYGTMPFDGF---------------DHKN CAMKL_NuaK_NuaK2 -KPYTGPEVDSWSLGVLLYILVHGTMPFDGH---------------DHKI CAMKL_HUNK_HUNK -KKY-GPKIDVWSIGVNMYAMLTGTLPFTVEP-------------FSLRA CAMKL_MELK_MELK -KSYLGSEADVWSMGILLYVLMCGFLPFDDD---------------NVMA CAMKL_NIM1_NIM1 -EHYIGIYVDIWALGVLLYFMVTGTMPFRAE---------------TVAK CAMKL_SNRK_SNRK -DEYDAPAVDIWSLGVILFMLVCGQPPFQEA---------------NDSE CAMKL_CHK1_CHK1 -REFHAEPVDVWSCGIVLTAMLAGELPWDQPS-------------DSCQE CAMKL_LKB_LKB1 -DTFSGFKVDIWSAGVTLYNITTGLYPFE--G-------------DNIYK TSSK__SSTK -IPYDPKKYDVWSMGVVLYVMVTGCMPFD--D-------------SDIAG TSSK__TSSK3 -IPHDSKKGDVWSMGVVLYVMLCASLPFD--D-------------TDIPK TSSK__TSSK2 -IPYQPKVYDIWSLGVILYIMVCGSMPYD--D-------------SDIRK TSSK__TSSK1 -IPYQPKVYDIWSLGVILYIMVCGSMPYD--D-------------SNIKK TSSK__TSSK4 -LPYNPFLSDTWSMGVILYTLVVAHLPFD--D-------------TNLKK PIM__PIM3 -HRYHGRSATVWSLGVLLYDMVCGDIPFE-----------------QDEE PIM__PIM1 -HRYHGRSAAVWSLGILLYDMVCGDIPFE-----------------HDEE PIM__PIM2 -HQYHALPATVWSLGILLYDMVCGDIPFE-----------------RDQE CAMKL_PASK_PASK -NPYRGPELEMWSLGVTLYTLVFEENPFC-----------------ELEE CAMK-Unique__STK33 -HDY-SQQCDIWSIGVVMYMLLRGEPPFLAS---------------SEAK DAPK__DAPK1 -YEPLGLEADMWSIGVITYILLSGASPFLGD---------------TKQE DAPK__DAPK3 -YEPLGLEADMWSIGVITYILLSGASPFLGE---------------TKQE DAPK__DAPK2 -YEPLGLEADMWSIGVITYILLSGASPFLGD---------------TKQE DAPK__DRAK1 -YDPISMATDMWSIGVLTYVMLTGISPFLGN---------------DKQE DAPK__DRAK2 -YDPITTATDMWNIGIIAYMLLTHTSPFVGE---------------DNQE MLCK__caMLCK -YEFVSFPTDMWSVGVITYMLLSGLSPFLGE---------------TDAE MLCK__SgK085 -YDFVSFPTDMWSVGVIAYMLLSGLSPFLGD---------------NDAE MLCK__skMLCK -YDQISDKTDMWSMGVITYMLLSGLSPFLGD---------------DDTE MLCK__smMLCK -YEPIGYATDMWSIGVICYILVSGLSPFMGD---------------NDNE MLCK__TTN -HDVVSTATDMWSLGTLVYVLLSGINPFLAE---------------TNQQ Trio__Trio -GNPVSLTSDTWSVGVLTYVLLSGVSPFLDD---------------SVEE Trio__Trad -GIPVSLGTDIWSIGVLTYVMLSGVSPFLDE---------------SKEE Trio__SPEG -QSPVSGVTDIWPVGVVAFLCLTGISPFVGE---------------NDRT Trio__Obscn -QNPVSEASDIWAMGVISYLSLTCSSPFAGE---------------SDRA Trio__Domain2_SPEG -GEPIGSATDIWGAGVLTYIMLSGRSPFYEP---------------DPQE Trio__Domain2_Obscn -GQGAVPQTDIWAIGVTAFIMLSAEYPVSSE---------------GARD PKD__PKD1 ---GYNRSLDMWSVGVIIYVSLSGTFPFNEDE-----------------D PKD__PKD3 ---GYNRSLDMWSVGVIIYVSLSGTFPFNEDE-----------------D PKD__PKD2 ---GYNRSLDMWSVGVIMYVSLSGTFPFNEDE-----------------D RAD53__CHK2 -TAGYNRAVDCWSLGVILFICLSGYPPFSEHRT--------------QVS CAMK1__CaMK1a -KP-YSKAVDCWSIGVIAYILLCGYPPF-YDEN--------------DAK CAMK1__CaMK1d -KP-YSKAVDCWSIGVIAYILLCGYPPF-YDEN--------------DSK CAMK1__CaMK1g -KP-YSKAVDCWSIGVITYILLCGYPPF-YEET--------------ESK CAMK1__CaMK1b -KP-YGKAVDVWALGVISYILLCGYPPF-YDES--------------DPE CAMK-Unique__VACAMKL -PP-FYEEVE------------EDD----YENH--------------DKN CAMK1__CaMK4 -CA-YGPEVDMWSVGIITYILLCGFEPF-YDERG-------------DQF PSK__PSKH1 -KP-YTNSVDMWALGVIAYILLSGTMPF-EDDN--------------RTR PSK__PSKH2 -KP-YTSAVDMWALGVITYALLSGFLPF-DDES--------------QTR DCAMKL__DCAMKL1 -TG-YGLKVDIWAAGVITYILLCGFPPFRGSGDD-------------QEV DCAMKL__DCAMKL2 -TG-YGLKVDIWAAGVITYILLCGFPPFRSENNL-------------QED DCAMKL__DCAMKL3 -KG-YGLEVDMWAAGVILYILLCGFPPFRSPERD-------------QDE PHK__PHKg1 -HPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQ---------------ML PHK__PHKg2 -HPGYGKEVDLWACGVILFTLLAGSPPFWHRRQ---------------IL CAMK2__CaMK2a -DP-YGKPVDLWACGVILYILLVGYPPFWDEDQ---------------HR CAMK2__CaMK2d -DP-YGKPVDMWACGVILYILLVGYPPFWDEDQ---------------HR CAMK2__CaMK2b -EA-YGKPVDIWACGVILYILLVGYPPFWDEDQ---------------HK CAMK2__CaMK2g -DP-YGKPVDIWACGVILYILLVGYPPFWDEDQ---------------HK CASK__CASK -EP-YGKPVDVWGCGVILFILLSGCLPFYG-TK---------------ER MAPKAPK_MAPKAPK_MAPKAPK2 ----YDKSCDMWSLGVIMYILLCGYPPFYSNHG-----------LAISPG MAPKAPK_MAPKAPK_MAPKAPK3 ----YDKSCDMWSLGVIMYILLCGFPPFYSNTG-----------QAISPG MAPKAPK_MAPKAPK_MAPKAPK5 TPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHS----------RTIPKD RSKb_MSKb_Domain2_MSK1 ----YDESCDLWSLGVILYTMLSGQVPFQSHDRSLT--------CTSAVE RSKb_MSKb_Domain2_MSK2 ----YDESCDLWSLGVILYMMLSGQVPFQGASGQGG--------QSQAAE RSKb_RSKb_Domain2_RSK2 ----YDAACDIWSLGVLLYTMLTGYTPFANGPDD------------TPEE RSKb_RSKb_Domain2_RSK3 ----YDEGCDIWSLGILLYTMLAGYTPFANGPSD------------TPEE RSKb_RSKb_Domain2_RSK1 ----YDAACDIWSLGILLYTMLAGFTPFANGPDD------------TPEE RSKb_RSKb_Domain2_RSK4 ----YDAACDIWSLGVLFYTMLAGYTPFANGPND------------TPEE Trbl__Trb1 --TYSGKAADVWSLGVMLYTLLVGRYPFH---------------DSDPSA Trbl__Trb2 --SYSGKAADVWSLGVMLYTMLVGRYPFH---------------DIEPSS Trbl__Trb3 --SYSGKAADVWSLGVALFTMLAGHYPFQ---------------DSEPVL CAMK-Unique__SgK495 --PYRGKPSDMWALGVVLFTMLYGQFPFY---------------DSIPQE MAPKAPK_MNK_MNK1 -ATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNK MAPKAPK_MNK_MNK2 -ASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNM CAMKL_AMPK_AMPKa1 LFKKICDGIFY-T-PQY--LNPSVISLLKHMLQVDPMKRASIKDIREHEW CAMKL_AMPK_AMPKa2 LFKKIRGGVFY-I-PEY--LNRSVATLLMHMLQVDPLKRATIKDIREHEW CAMKL_BRSK_BRSK2 LLEKVKRGVFH-M-PHF--IPPDCQSLLRGMIEVDAARRLTLEHIQKHIW CAMKL_BRSK_BRSK1 LLEKVKRGVFH-M-PHF--IPPDCQSLLRGMIEVEPEKRLSLEQIQKHPW CAMKL_MARK_MARK2 LRERVLRGKYR-I-PFY--MSTDCENLLKKFLILNPSKRGTLEQIMKDRW CAMKL_MARK_MARK1 LRERVLRGKYR-I-PFY--MSTDCENLLKKLLVLNPIKRGSLEQIMKDRW CAMKL_MARK_MARK3 LRERVLRGKYR-I-PFY--MSTDCENLLKRFLVLNPIKRGTLEQIMKDRW CAMKL_MARK_MARK4 LRERVLRGKYR-V-PFY--MSTDCESILRRFLVLNPAKRCTLEQIMKDKW CAMKL_QIK_QIK LRQRVLEGRFR-I-PYF--MSEDCEHLIRRMLVLDPSKRLTIAQIKEHKW CAMKL_QIK_SIK LRQRVLEGRFR-I-PFF--MSQDCESLIRRMLVVDPARRITIAQIRQHRW CAMKL_QIK_QSK LRARVLSGKFR-I-PFF--MSTECEHLIRHMLVLDPNKRLSMEQICKHKW CAMKL_NuaK_NuaK1 LIRQISSGEYR-E-PT---QPSDARGLIRWMLMVNPDRRATIEDIANHWW CAMKL_NuaK_NuaK2 LVKQISNGAYR-E-PP---KPSDCLGLIRWLLMVNPTRRATLEDVASHWW CAMKL_HUNK_HUNK LYQKMVDKEMNPL-PTQ--LSTGAISFLRSLLEPDPVKRPNIQQALANRW CAMKL_MELK_MELK LYKKIMRGKYD-V-PKW--LSPSSILLLQQMLQVDPKKRISMKNLLNHPW CAMKL_NIM1_NIM1 LKKSILEGTYS-V-PPH--VSEPCHRLIRGVLQQIPTERYGIDCIMNDEW CAMKL_SNRK_SNRK TLTMIMDCKYT-V-PSH--VSKECKDLITRMLQRDPKRRASLEEIENHPW CAMKL_CHK1_CHK1 YSDWKEKKTYL-N-PWK-KIDSAPLALLHKILVENPSARITIPDIKKDRW CAMKL_LKB_LKB1 LFENIGKGSYA-I-PG--DCGPPLSDLLKGMLEYEPAKRFSIRQIRQHSW TSSK__SSTK LPRRQKRG-VL-Y-PEGLELSERCKALIAELLQFSPSARPSAGQVARNCW TSSK__TSSK3 MLWQQQKG-VS-F-PTHLSISADCQDLLKRLLEPDMILRPSIEEVSWHPW TSSK__TSSK2 MLRIQKEHRVD-F-PRSKNLTCECKDLIYRMLQPDVSQRLHIDEILSHSW TSSK__TSSK1 MLRIQKEHRVN-F-PRSKHLTGECKDLIYHMLQPDVNRRLHIDEILSHCW TSSK__TSSK4 LLRETQKE-VT-F-PANHTISQECKNLILQMLR-QATKRATILDIIKDSW PIM__PIM3 ILRGRLLFRRR--------VSPECQQLIRWCLSLRPSERPSLDQIAAHPW PIM__PIM1 IIRGQVFFRQR--------VSSECQHLIRWCLALRPSDRPTFEEIQNHPW PIM__PIM2 ILEAELHFPAH--------VSPDCCALIRRCLAPKPSSRPSLEEILLDPW CAMKL_PASK_PASK TVEAAIHPPYL--------VSKELMSLVSGLLQPVPERRTTLEKLVTDPW CAMK-Unique__STK33 LFELIRKGELHFENAVWNSISDCAKSVLKQLMKVDPAHRITAKELLDNQW DAPK__DAPK1 TLANVSAVNYEFEDEYFSNTSALAKDFIRRLLVKDPKKRMTIQDSLQHPW DAPK__DAPK3 TLTNISAVNYDFDEEYFSNTSELAKDFIRRLLVKDPKRRMTIAQSLEHSW DAPK__DAPK2 TLANITAVSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPW DAPK__DRAK1 TFLNISQMNLSYSEEEFDVLSESAVDFIRTLLVKKPEDRATAEECLKHPW DAPK__DRAK2 TYLNISQVNVDYSEETFSSVSQLATDFIQSLLVKNPEKRPTAEICLSHSW MLCK__caMLCK TMNFIVNCSWDFDADTFEGLSEEAKDFVSRLLVKEKSCRMSATQCLKHEW MLCK__SgK085 TLNNILACRWDLEDEEFQDISEEAKEFISKLLIKEKSWRISASEALKHPW MLCK__skMLCK TLNNVLSGNWYFDEETFEAVSDEAKDFVSNLIVKDQRARMNAAQCLAHPW MLCK__smMLCK TLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKNRLDCTQCLQHPW MLCK__TTN IIENIMNAEYTFDEEAFKEISIEAMDFVDRLLVKERKSRMTASEALQHPW Trio__Trio TCLNICRLDFSFPDDYFKGVSQKAKEFVCFLLQEDPAKRPSAALALQEQW Trio__Trad TCINVCRVDFSFPHEYFCGVSNAARDFINVILQEDFRRRPTAATCLQHPW Trio__SPEG TLMNIRNYNVAFEETTFLSLSREARGFLIKVLVQD-RLRPTAEETLEHPW Trio__Obscn TLLNVLEGRVSWSSPMAAHLSEDAKDFIKATLQRAPQARPSAAQCLSHPW Trio__Domain2_SPEG TEARIVGGRFDAFQ-LYPNTSQSATLFLRKVLSVHPWSRPSLQDCLAHPW Trio__Domain2_Obscn LQRGLRKGLVRLSR-CYAGLSGGAVAFLRSTLCAQPWGRPCASSCLQCPW PKD__PKD1 IHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLSHPW PKD__PKD3 INDQIQNAAFMYPPNPWREISGEAIDLINNLLQVKMRKRYSVDKSLSHPW PKD__PKD2 INDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKSLSHPW RAD53__CHK2 LKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPW CAMK1__CaMK1a LFEQILKAEYEFDSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPW CAMK1__CaMK1d LFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPW CAMK1__CaMK1g LFEKIKEGYYEFESPFWDDISESAKDFICHLLEKDPNERYTCEKALSHPW CAMK1__CaMK1b LFSQILRASYEFDSPFWGDISESAKDFIRHLLERDPQKRFTCQQALRHLW CAMK-Unique__VACAMKL LFRKILAGDYEFDSPYWDDISQAAKDLVTRLMEVEQDQRITAEEAISHEW CAMK1__CaMK4 MFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLDPKKRLTTFQALQHPW PSK__PSKH1 LYRQILRGKYSYSGEPWPSVSNLAKDFIDRLLTVDPGARMTALQALRHPW PSK__PSKH2 LYRKILKGKYNYTGEPWPSISHLAKDFIDKLLILEAGHRMSAGQALDHPW DCAMKL__DCAMKL1 LFDQILMGQVDFPSPYWDNVSDSAKELITMMLLVDVDQRFSAVQVLEHPW DCAMKL__DCAMKL2 LFDQILAGKLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGQILSHPW DCAMKL__DCAMKL3 LFNIIQLGHFEFLPPYWDNISDAAKDLVSRLLVVDPKKRYTAHQVLQHPW PHK__PHKg1 MLRMIMSGNYQFGSPEWDDYSDTVKDLVSRFLVVQPQNRYTAEEALAHPF PHK__PHKg2 MLRMIMEGQYQFSSPEWDDRSSTVKDLISRLLQVDPEARLTAEQALQHPF CAMK2__CaMK2a LYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPW CAMK2__CaMK2d LYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPW CAMK2__CaMK2b LYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPW CAMK2__CaMK2g LYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPW CASK__CASK LFEGIIKGKYKMNPRQWSHISESAKDLVRRMLMLDPAERITVYEALNHPW MAPKAPK_MAPKAPK_MAPKAPK2 MKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPW MAPKAPK_MAPKAPK_MAPKAPK3 MKRRIRLGQYGFPNPEWSEVSEDAKQLIRLLLKTDPTERLTITQFMNHPW MAPKAPK_MAPKAPK_MAPKAPK5 MRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPERRLTIEGVLDHPW RSKb_MSKb_Domain2_MSK1 IMKKIKKGDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEW RSKb_MSKb_Domain2_MSK2 IMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKLEGLRGSSW RSKb_RSKb_Domain2_RSK2 ILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPW RSKb_RSKb_Domain2_RSK3 ILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPW RSKb_RSKb_Domain2_RSK1 ILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQVLKHPW RSKb_RSKb_Domain2_RSK4 ILLRIGNGKFSLSGGNWDNISDGAKDLLSHMLHMDPHQRYTAEQILKHSW Trbl__Trb1 LFSKIRRGQFCIPEH----ISPKARCLIRSLLRREPSERLTAPEILLHPW Trbl__Trb2 LFSKIRRGQFNIPET----LSPKAKCLIRSILRREPSERLTSQEILDHPW Trbl__Trb3 LFGKIRRGAYALPAG----LSAPARCLVRCLLRREPAERLTATGILLHPW CAMK-Unique__SgK495 LFRKIKAAEYTIPEDGR--VSENTVCLIRKLLVLDPQQRLAAADVLEAL- MAPKAPK_MNK_MNK1 LFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPW MAPKAPK_MNK_MNK2 LFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPW .: : * CAMKL_AMPK_AMPKa1 F CAMKL_AMPK_AMPKa2 F CAMKL_BRSK_BRSK2 Y CAMKL_BRSK_BRSK1 Y CAMKL_MARK_MARK2 M CAMKL_MARK_MARK1 M CAMKL_MARK_MARK3 I CAMKL_MARK_MARK4 I CAMKL_QIK_QIK M CAMKL_QIK_SIK M CAMKL_QIK_QSK M CAMKL_NuaK_NuaK1 V CAMKL_NuaK_NuaK2 V CAMKL_HUNK_HUNK L CAMKL_MELK_MELK I CAMKL_NIM1_NIM1 M CAMKL_SNRK_SNRK L CAMKL_CHK1_CHK1 Y CAMKL_LKB_LKB1 F TSSK__SSTK L TSSK__TSSK3 L TSSK__TSSK2 L TSSK__TSSK1 M TSSK__TSSK4 V PIM__PIM3 M PIM__PIM1 M PIM__PIM2 M CAMKL_PASK_PASK V CAMK-Unique__STK33 L DAPK__DAPK1 I DAPK__DAPK3 I DAPK__DAPK2 I DAPK__DRAK1 L DAPK__DRAK2 L MLCK__caMLCK L MLCK__SgK085 L MLCK__skMLCK L MLCK__smMLCK L MLCK__TTN L Trio__Trio L Trio__Trad L Trio__SPEG F Trio__Obscn F Trio__Domain2_SPEG L Trio__Domain2_Obscn L PKD__PKD1 L PKD__PKD3 L PKD__PKD2 L RAD53__CHK2 L CAMK1__CaMK1a I CAMK1__CaMK1d I CAMK1__CaMK1g I CAMK1__CaMK1b V CAMK-Unique__VACAMKL I CAMK1__CaMK4 V PSK__PSKH1 V PSK__PSKH2 V DCAMKL__DCAMKL1 V DCAMKL__DCAMKL2 V DCAMKL__DCAMKL3 I PHK__PHKg1 F PHK__PHKg2 F CAMK2__CaMK2a I CAMK2__CaMK2d I CAMK2__CaMK2b V CAMK2__CaMK2g V CASK__CASK L MAPKAPK_MAPKAPK_MAPKAPK2 I MAPKAPK_MAPKAPK_MAPKAPK3 I MAPKAPK_MAPKAPK_MAPKAPK5 L RSKb_MSKb_Domain2_MSK1 L RSKb_MSKb_Domain2_MSK2 L RSKb_RSKb_Domain2_RSK2 I RSKb_RSKb_Domain2_RSK3 V RSKb_RSKb_Domain2_RSK1 V RSKb_RSKb_Domain2_RSK4 I Trbl__Trb1 F Trbl__Trb2 F Trbl__Trb3 L CAMK-Unique__SgK495 - MAPKAPK_MNK_MNK1 V MAPKAPK_MNK_MNK2 V