CLUSTAL W (1.8) multiple sequence alignment CDKL__CDKL2 -YENLGLVGEGSYGMVMKCRNKDTG--RIVAIKKFLESDDD-KMVK-------------- CDKL__CDKL3 -YETLGKVGEGSYGTVMKCKHKNTG--QIVAIKIFYERPE--QSVN-------------- CDKL__CDKL1 -YEKIGKIGEGSYGVVFKCRNRDTG--QIVAIKKFLESEDD-PVIK-------------- CDKL__CDKL4 -YEKLAKTGEGSYGVVFKCRNKTSG--QVVAVKKFVESEDD-PVVK-------------- CDKL__CDKL5 -FEILGVVGEGAYGVVLKCRHKETH--EIVAIKKFKDSEEN-EEVK-------------- CDK_CDK7_CDK7 -YEKLDFLGEGQFATVYKARDKNTN--QIVAIKKIKLGHRSEAKDG-------------- CDK__CCRK -YCILGRIGEGAHGIVFKAKHVETG--EIVALKKVALRR---LEDG-------------- CDK_CDK10_CDK10 -FEKLNRIGEGTYGIVYRARDTQTD--EIVALKKVRMDK---EKDG-------------- CDK_PITSLRE_PITSLRE -FQCLNRIEEGTYGVVYRAKDKKTD--EIVALKRLKMEK---EKEG-------------- CDK_CRK7_CHED -FDIIGIIGEGTYGQVYKARDKDTG--EMVALKKVRLDN---EKEG-------------- CDK_CRK7_CRK7 -FDIIGIIGEGTYGQVYKARDKDTG--ELVALKKVRLDN---EKEG-------------- CDK_CDK9_CDK9 -YEKLAKIGQGTFGEVFKARHRKTG--QKVALKKVLMEN---EKEG-------------- CDK_CDC2_CDK2 -FQKVEKIGEGTYGVVYKARNKLTG--EVVALKKIRLDT---ETEG-------------- CDK_CDC2_CDK3 -FQKVEKIGEGTYGVVYKAKNRETG--QLVALKKIRLDL---EMEG-------------- CDK_CDC2_CDC2 -YTKIEKIGEGTYGVVYKGRHKTTG--QVVAMKKIRLES---EEEG-------------- CDK_CDK5_CDK5 -YEKLEKIGEGTYGTVFKAKNRETH--EIVALKRVRLDD---DDEG-------------- CDK_TAIRE_PCTAIRE1 -YIKLDKLGEGTYATVYKGKSKLTD--NLVALKEIRLEH---E-EG-------------- CDK_TAIRE_PCTAIRE2 -YIKLEKLGEGTYATVYKGRSKLTE--NLVALKEIRLEH---E-EG-------------- CDK_TAIRE_PCTAIRE3 -YVKLDKLGEGTYATVFKGRSKLTE--NLVALKEIRLEH---E-EG-------------- CDK_TAIRE_PFTAIRE1 -YEKLEKLGEGSYATVYKGKSKVNG--KLVALKVIRLQE---E-EG-------------- CDK_TAIRE_PFTAIRE2 -YLNLEKLGEGSYATVYKGISRING--QLVALKVISMNA---E-EG-------------- CDK_CDK4_CDK4 -YEPVAEIGVGAYGTVYKARDPHSG--HFVALKSVRVPN---GGGGGGG----------- CDK_CDK4_CDK6 -YECVAEIGEGAYGKVFKARDLKNGG-RFVALKRVRVQT---GEEG-------------- CDK_CDK8_CDK8 FEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEG-------TG-------------- CDK_CDK8_CDK11 FEYEGCKVGRGTYGHVYKARRKDGKDEKEYALKQIEG-------TG-------------- MAPK_ERK_Erk1 -YTQLQYIGEGAYGMVSSAYDHVRK--TRVAIKKIS-PFEHQTYCQ-------------- MAPK_ERK_Erk2 -YTNLSYIGEGAYGMVCSAYDNVNK--VRVAIKKIS-PFEHQTYCQ-------------- MAPK_ERK_Erk5 -YEIIETIGNGAYGVVSSARRRLTG--QQVAIKKIPNAFDVVTNAK-------------- MAPK_nmo_NLK -IEPDRPIGYGAFGVVWSVTDPRDG--KRVALKKMPNVFQNLVSCK-------------- MAPK_JNK_JNK1 -YQNLKPIGSGAQGIVCAAYDAILE--RNVAIKKLSRPFQNQTHAK-------------- MAPK_JNK_JNK3 -YQNLKPIGSGAQGIVCAAYDAVLD--RNVAIKKLSRPFQNQTHAK-------------- MAPK_JNK_JNK2 -YQQLKPIGSGAQGIVCAAFDTVLG--INVAVKKLSRPFQNQTHAK-------------- MAPK_p38_p38a -YQNLSPVGSGAYGSVCAAFDTKTG--LRVAVKKLSRPFQSIIHAK-------------- MAPK_p38_p38b -LQGLRPVGSGAYGSVCSAYDARLR--QKVAVKKLSRPFQSLIHAR-------------- MAPK_p38_p38g -YRDLQPVGSGAYGAVCSAVDGRTG--AKVAIKKLYRPFQSELFAK-------------- MAPK_p38_p38d -YVSPTHVGSGAYGSVCSAIDKRSG--EKVAIKKLSRPFQSEIFAK-------------- MAPK_Erk7_Erk7 -YLLRRQLGQGAYGIVWKAVDRRTG--EVVAIKKIFDAFRDKTDAQDMGFLLAPPTHTPV MAPK_ERK_Erk3 -YMDLKPLGCGGNGLVFSAVDNDCD--KRVAIKKIV--LTDPQSVK-------------- MAPK_ERK_Erk4 -FVDFQPLGFGVNGLVLSAVDSRAC--RKVAVKKIA--LSDARSMK-------------- RCK__MAK -YTTMRQLGDGTYGSVLMGKSNESG--ELVAIKRMKRKFYSWDECMN------------- RCK__ICK -YTTIRQLGDGTYGSVLLGRSIESG--ELIAIKKMKRKFYSWEECMN------------- RCK__MOK -YKAIGKIGEGTFSEVMKMQSLRDG--NYYACKQMKQRFESIEQVNN------------- GSK__GSK3A -YTDIKVIGNGSFGVVYQARLAETR--ELVAIKKVLQDK-----R--------------- GSK__GSK3B -YTDTKVIGNGSFGVVYQAKLCDSG--ELVAIKKVLQDK-----R--------------- CLK__CLK1 -YEIVDTLGEGAFGKVVECIDHKAGG-RHVAVKIVKNVD---RYCE-------------- CLK__CLK4 --EIVDTLGEGAFGKVVECIDHGMDG-MHVAVKIVKNVG---RYRE-------------- CLK__CLK2 -YEIVSTLGEGTFGRVVQCVDHRRGG-ARVALKIIKNVE---KYKE-------------- CLK__CLK3 -YEIVGNLGEGTFGKVVECLDHARGK-SQVALKIIRNVG---KYRE-------------- SRPK__SRPK2 -YHVIRKLGWGHFSTVWLCWDMQ-GK-RFVAMKVVKSAQ---HYTE-------------- SRPK__MSSK1 -YHVVRKLGWGHFSTVWLCWDIQ-RK-RFVALKVVKSAG---HYTE-------------- SRPK__SRPK1 -YHVIRKLGWGHFSTVWLSWDIQ-GK-KFVAMKVVKSAE---HYTE-------------- DYRK_Dyrk1_DYRK1B -YEIDSLIGKGSFGQVVKAYDHQ-TQ-ELVAIKIIKNKK---AFLN-------------- DYRK_Dyrk1_DYRK1A -YEIDSLIGKGSFGQVVKAYDRV-EQ-EWVAIKIIKNKK---AFLN-------------- DYRK_Dyrk2_DYRK2 -YEVLKVIGKGSFGQVVKAYDHK-VH-QHVALKMVRNEK---RFHR-------------- DYRK_Dyrk2_DYRK3 -YEVLKIIGKGSFGQVARVYDHK-LR-QYVALKMVRNEK---RFHR-------------- DYRK_Dyrk2_DYRK4 -YEVLETIGKGSFGQVAKCLDHK-NN-ELVALKIIRNKK---RFHQ-------------- DYRK_HIPK_HIPK1 -YEVLEFLGRGTFGQVAKCWKRS-TK-EIVAIKILKNHP---SYAR-------------- DYRK_HIPK_HIPK2 -YEVLEFLGRGTFGQVVKCWKRG-TN-EIVAIKILKNHP---SYAR-------------- DYRK_HIPK_HIPK3 -YEVLDFLGRGTFGQVVKCWKRG-TN-EIVAIKILKNHP---SYAR-------------- DYRK_HIPK_HIPK4 -YDIIEVLGKGTFGEVAKGWRRS-TG-EMVAIKILKNDA---YRNR-------------- DYRK_PRP4_PRP4 -YNVYGYTGQGVFSNVVRARDNARAN-QEVAVKIIRNNE---LMQK-------------- * . * * * . CDKL__CDKL2 ----KIAMREIKLLKQLR---HEN-----LVNLLEVCKK--------------KKRWYLV CDKL__CDKL3 ----KIAMREIKFLKQFH---HEN-----LVNLIEVFRQ--------------KKKIHLV CDKL__CDKL1 ----KIALREIRMLKQLK---HPN-----LVNLLEVFRR--------------KRRLHLV CDKL__CDKL4 ----KIALREIRMLKQLK---HPN-----LVNLIEVFRR--------------KRKMHLV CDKL__CDKL5 ----ETTLRELKMLRTLK---QEN-----IVELKEAFRR--------------RGKLYLV CDK_CDK7_CDK7 --INRTALREIKLLQELS---HPN-----IIGLLDAFGH--------------KSNISLV CDK__CCRK --FPNQALREIKALQEMED--NQY-----VVQLKAVFPH--------------GGGFVLA CDK_CDK10_CDK10 --IPISSLREITLLLRLR---HPN-----IVELKEVVVGN---------H---LESIFLV CDK_PITSLRE_PITSLRE --FPITSLREINTILKAQ---HPN-----IVTVREIVVGS---------N---MDKIYIV CDK_CRK7_CHED --FPITAIREIKILRQLT---HQS-----IINMKEIVTDKED----ALDFKKDKGAFYLV CDK_CRK7_CRK7 --FPITAIREIKILRQLI---HRS-----VVNMKEIVTDKQD----ALDFKKDKGAFYLV CDK_CDK9_CDK9 --FPITALREIKILQLLK---HEN-----VVNLIEICRTK------ASPYNRCKGSIYLV CDK_CDC2_CDK2 --VPSTAIREISLLKELN---HPN-----IVKLLDVIHT--------------ENKLYLV CDK_CDC2_CDK3 --VPSTAIREISLLKELK---HPN-----IVRLLDVVHN--------------ERKLYLV CDK_CDC2_CDC2 --VPSTAIREISLLKELR---HPN-----IVSLQDVLMQ--------------DSRLYLI CDK_CDK5_CDK5 --VPSSALREICLLKELK---HKN-----IVRLHDVLHS--------------DKKLTLV CDK_TAIRE_PCTAIRE1 --APCTAIREVSLLKDLK---HAN-----IVTLHDIIHT--------------EKSLTLV CDK_TAIRE_PCTAIRE2 --APCTAIREVSLLKDLK---HAN-----IVTLHDIVHT--------------DKSLTLV CDK_TAIRE_PCTAIRE3 --APCTAIREVSLLKNLK---HAN-----IVTLHDLIHT--------------DRSLTLV CDK_TAIRE_PFTAIRE1 --TPFTAIREASLLKGLK---HAN-----IVLLHDIIHT--------------KETLTLV CDK_TAIRE_PFTAIRE2 --VPFTAIREASLLKGLK---HAN-----IVLLHDIIHT--------------KETLTFV CDK_CDK4_CDK4 --LPISTVREVALLRRLEAFEHPN-----VVRLMDVCATS---------RTDREIKVTLV CDK_CDK4_CDK6 --MPLSTIREVAVLRHLETFEHPN-----VVRLFDVCTVS---------RTDRETKLTLV CDK_CDK8_CDK8 --ISMSACREIALLRELK---HPN-----VISLQKVFLSH---------A---DRKVWLL CDK_CDK8_CDK11 --ISMSACREIALLRELK---HPN-----VIALQKVFLSH---------S---DRKVWLL MAPK_ERK_Erk1 -----RTLREIQILLRF---RHEN-----VIGIRDILRAST---------LEAMRDVYIV MAPK_ERK_Erk2 -----RTLREIKILLRF---RHEN-----IIGINDIIRAPT---------IEQMKDVYIV MAPK_ERK_Erk5 -----RTLRELKILKHF---KHDN-----IIAIKDILRPTVP--------YGEFKSVYVV MAPK_nmo_NLK -----RVFRELKMLCFF---KHDN-----VLSALDILQPPH---------IDYFEEIYVV MAPK_JNK_JNK1 -----RAYRELVLMKCV---NHKN-----IIGLLNVFTPQKS--------LEEFQDVYIV MAPK_JNK_JNK3 -----RAYRELVLMKCV---NHKN-----IISLLNVFTPQKT--------LEEFQDVYLV MAPK_JNK_JNK2 -----RAYRELVLLKCV---NHKN-----IISLLNVFTPQKT--------LEEFQDVYLV MAPK_p38_p38a -----RTYRELRLLKHM---KHEN-----VIGLLDVFTPARS--------LEEFNDVYLV MAPK_p38_p38b -----RTYRELRLLKHL---KHEN-----VIGLLDVFTPATS--------IEDFSEVYLV MAPK_p38_p38g -----RAYRELRLLKHM---RHEN-----VIGLLDVFTPDET--------LDDFTDFYLV MAPK_p38_p38d -----RAYRELLLLKHM---QHEN-----VIGLLDVFTPASS--------LRNFYDFYLV MAPK_Erk7_Erk7 FLSLQRTFREITLLQEFG--DHPN-----IISLLDVIRAEN-----------D-RDIYLV MAPK_ERK_Erk3 -----HALREIKIIRRL---DHDN-----IVKVFEILGPSGSQLTDDVGSLTELNSVYIV MAPK_ERK_Erk4 -----HALREIKIIRRL---DHDN-----IVKVYEVLGPKG---TDLQGELFKFSVAYIV RCK__MAK -------LREVKSLKKLN---HAN-----VIKLKEVIRE--------------NDHLYFI RCK__ICK -------LREVKSLKKLN---HAN-----VVKLKEVIRE--------------NDHLYFI RCK__MOK -------LREIQALRRLNP--HPN-----ILMLHEVVFDRK------------SGSLALI GSK__GSK3A -----FKNRELQIMRKLD---HCN-----IVRLRYFFYSSGE--------KKDELYLNLV GSK__GSK3B -----FKNRELQIMRKLD---HCN-----IVRLRYFFYSSGE--------KKDEVYLNLV CLK__CLK1 -----AARSEIQVLEHLNTTDPN--STFRCVQMLEWFEHHG--------------HICIV CLK__CLK4 -----AARSEIQVLEHLNSTDPN--SVFRCVQMLEWFDHHG--------------HVCIV CLK__CLK2 -----AARLEINVLEKINEKDPD--NKNLCVQMFDWFDYHG--------------HMCIS CLK__CLK3 -----AARLEINVLKKIKEKDKE--NKFLCVLMSDWFNFHG--------------HMCIA SRPK__SRPK2 -----TALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGM----------NGIHVCMV SRPK__MSSK1 -----TAVDEIKLLKCVRDSDPSDPKRETIVQLIDDFRISGV----------NGVHVCMV SRPK__SRPK1 -----TALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGV----------NGTHICMV DYRK_Dyrk1_DYRK1B -----QAQIELRLLELMNQHDTEM--KYYIVHLKRHFMFRN--------------HLCLV DYRK_Dyrk1_DYRK1A -----QAQIEVRLLELMNKHDTEM--KYYIVHLKRHFMFRN--------------HLCLV DYRK_Dyrk2_DYRK2 -----QAAEEIRILEHLRKQDKDN--TMNVIHMLENFTFRN--------------HICMT DYRK_Dyrk2_DYRK3 -----QAAEEIRILEHLKKQDKTG--SMNVIHMLESFTFRN--------------HVCMA DYRK_Dyrk2_DYRK4 -----QALMELKILEALRKKDKDN--TYNVVHMKDFFYFRN--------------HFCIT DYRK_HIPK_HIPK1 -----QGQIEVSILSRLSSENAD---EYNLVRSYECFQHKN--------------HTCLV DYRK_HIPK_HIPK2 -----QGQIEVSILARLSTESAD---DYNFVRAYECFQHKN--------------HTCLV DYRK_HIPK_HIPK3 -----QGQIEVSILARLSTENAD---EYNFVRAYECFQHRN--------------HTCLV DYRK_HIPK_HIPK4 -----IIKNELKLLHCMRGLDPE---EAHVIRFLEFFHDAL--------------KFYLV DYRK_PRP4_PRP4 -----TGLKELEFLKKLNDADPDD--KFHCLRLFRHFYHKQ--------------HLCLV * : : . CDKL__CDKL2 FEFVDHTILDDLELFP--------NGLDYQVVQKYLFQIINGIGFCHSHN--IIHRDIKP CDKL__CDKL3 FEFIDHTVLDELQHYC--------HGLESKRLRKYLFQILRAIDYLHSNN--IIHRDIKP CDKL__CDKL1 FEYCDHTVLHELDRYQ--------RGVPEHLVKSITWQTLQAVNFCHKHN--CIHRDVKP CDKL__CDKL4 FEYCDHTLLNELERNP--------NGVADGVIKSVLWQTLQALNFCHIHN--CIHRDIKP CDKL__CDKL5 FEYVEKNMLELLEEMP--------NGVPPEKVKSYIYQLIKAIHWCHKND--IVHRDIKP CDK_CDK7_CDK7 FDFMETDLEVIIKDNS--------LVLTPSHIKAYMLMTLQGLEYLHQHW--ILHRDLKP CDK__CCRK FEFMLSDLAEVVRHAQ--------RPLAQAQVKSYLQMLLKGVAFCHANN--IVHRDLKP CDK_CDK10_CDK10 MGYCEQDLASLLENMP--------TPFSEAQVKCIVLQVLRGLQYLHRNF--IIHRDLKV CDK_PITSLRE_PITSLRE MNYVEHDLKSLMETMK--------QPFLPGEVKTLMIQLLRGVKHLHDNW--ILHRDLKT CDK_CRK7_CHED FEYMDHDLMGLLESGL--------VHFYENHIKSFMRQLMEGLDYCHKKN--FLHRDIKC CDK_CRK7_CRK7 FEYMDHDLMGLLESGL--------VHFSEDHIKSFMKQLMEGLEYCHKKN--FLHRDIKC CDK_CDK9_CDK9 FDFCEHDLAGLLSNVL--------VKFTLSEIKRVMQMLLNGLYYIHRNK--ILHRDMKA CDK_CDC2_CDK2 FEFLHQDLKKFMDASA-------LTGIPLPLIKSYLFQLLQGLAFCHSHR--VLHRDLKP CDK_CDC2_CDK3 FEFLSQDLKKYMDSTP-------GSELPLHLIKSYLFQLLQGVSFCHSHR--VIHRDLKP CDK_CDC2_CDC2 FEFLSMDLKKYLDSIPP------GQYMDSSLVKSYLYQILQGIVFCHSRR--VLHRDLKP CDK_CDK5_CDK5 FEFCDQDLKKYFDSCN--------GDLDPEIVKSFLFQLLKGLGFCHSRN--VLHRDLKP CDK_TAIRE_PCTAIRE1 FEYLDKDLKQYLDDCG--------NIINMHNVKLFLFQLLRGLAYCHRQK--VLHRDLKP CDK_TAIRE_PCTAIRE2 FEYLDKDLKQYMDDCG--------NIMSMHNVKLFLYQILRGLAYCHRRK--VLHRDLKP CDK_TAIRE_PCTAIRE3 FEYLDSDLKQYLDHCG--------NLMSMHNVKIFMFQLLRGLAYCHHRK--ILHRDLKP CDK_TAIRE_PFTAIRE1 FEYVHTDLCQYMDKHP--------GGLHPDNVKLFLFQLLRGLSYIHQRY--ILHRDLKP CDK_TAIRE_PFTAIRE2 FEYMHTDLAQYMSQHP--------GGLHPHNVRLFMFQLLRGLAYIHHQH--VLHRDLKP CDK_CDK4_CDK4 FEHVDQDLRTYLDKAP-------PPGLPAETIKDLMRQFLRGLDFLHANC--IVHRDLKP CDK_CDK4_CDK6 FEHVDQDLTTYLDKVP-------EPGVPTETIKDMMFQLLRGLDFLHSHR--VVHRDLKP CDK_CDK8_CDK8 FDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHYLHANW--VLHRDLKP CDK_CDK8_CDK11 FDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHANW--VLHRDLKP MAPK_ERK_Erk1 QDLMETDLYKLLKS-QQ---------LSNDHICYFLYQILRGLKYIHSAN--VLHRDLKP MAPK_ERK_Erk2 QDLMETDLYKLLKT-QH---------LSNDHICYFLYQILRGLKYIHSAN--VLHRDLKP MAPK_ERK_Erk5 LDLMESDLHQIIHSSQP---------LTLEHVRYFLYQLLRGLKYMHSAQ--VIHRDLKP MAPK_nmo_NLK TELMQSDLHKIIVSPQP---------LSSDHVKVFLYQILRGLKYLHSAG--ILHRDIKP MAPK_JNK_JNK1 MELMDANLCQVIQ-ME----------LDHERMSYLLYQMLCGIKHLHSAG--IIHRDLKP MAPK_JNK_JNK3 MELMDANLCQVIQ-ME----------LDHERMSYLLYQMLCGIKHLHSAG--IIHRDLKP MAPK_JNK_JNK2 MELMDANLCQVIH-ME----------LDHERMSYLLYQMLCGIKHLHSAG--IIHRDLKP MAPK_p38_p38a THLMGADLNNIVKCQK----------LTDDHVQFLIYQILRGLKYIHSAD--IIHRDLKP MAPK_p38_p38b TTLMGADLNNIVKCQAGAHQGA--RLALDEHVQFLVYQLLRGLKYIHSAG--IIHRDLKP MAPK_p38_p38g MPFMGTDLGKLMKHEK----------LGEDRIQFLVYQMLKGLRYIHAAG--IIHRDLKP MAPK_p38_p38d MPFMQTDLQKIMG-ME----------FSEEKIQYLVYQMLKGLKYIHSAG--VVHRDLKP MAPK_Erk7_Erk7 FEFMDTDLNAVIRKGG---------LLQDVHVRSIFYQLLRATRFLHSGH--VVHRDQKP MAPK_ERK_Erk3 QEYMETDLANVLEQGP----------LLEEHARLFMYQLLRGLKYIHSAN--VLHRDLKP MAPK_ERK_Erk4 QEYMETDLARLLEQGT----------LAEEHAKLFMYQLLRGLKYIHSAN--VLHRDLKP RCK__MAK FEYMKENLYQLMKDRN--------KLFPESVIRNIMYQILQGLAFIHKHG--FFHRDMKP RCK__ICK FEYMKENLYQLIKERN--------KLFPESAIRNIMYQILQGLAFIHKHG--FFHRDLKP RCK__MOK CELMDMNIYELIRGRR--------YPLSEKKIMHYMYQLCKSLDHIHRNG--IFHRDVKP GSK__GSK3A LEYVPETVYRVARHFTK-----AKLTIPILYVKVYMYQLFRSLAYIHSQG--VCHRDIKP GSK__GSK3B LDYVPETVYRVARHYSR-----AKQTLPVIYVKLYMYQLFRSLAYIHSFG--ICHRDIKP CLK__CLK1 FELLGLSTYDFIKEN-------GFLPFRLDHIRKMAYQICKSVNFLHSN--KLTHTDLKP CLK__CLK4 FELLGLSTYDFIKEN-------SFLPFQIDHIRQMAYQICQSINFLHHN--KLTHTDLKP CLK__CLK2 FELLGLSTFDFLKDN-------NYLPYPIHQVRHMAFQLCQAVKFLHDN--KLTHTDLKP CLK__CLK3 FELLGKNTFEFLKEN-------NFQPYPLPHVRHMAYQLCHALRFLHEN--QLTHTDLKP SRPK__SRPK2 FEVLGHHLLKWIIKS-------NYQGLPVRCVKSIIRQVLQGLDYLHSKC-KIIHTDIKP SRPK__MSSK1 LEVLGHQLLKWIIKS-------NYQGLPVPCVKSIVRQVLHGLDYLHTKC-KIIHTDIKP SRPK__SRPK1 FEVLGHHLLKWIIKS-------NYQGLPLPCVKKIIQQVLQGLDYLHTKC-RIIHTDIKP DYRK_Dyrk1_DYRK1B FELLSYNLYDLLRNT-------HFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKP DYRK_Dyrk1_DYRK1A FEMLSYNLYDLLRNT-------NFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKP DYRK_Dyrk2_DYRK2 FELLSMNLYELIKKN-------KFQGFSLPLVRKFAHSILQCLDALHKNR--IIHCDLKP DYRK_Dyrk2_DYRK3 FELLSIDLYELIKKN-------KFQGFSVQLVRKFAQSILQSLDALHKNK--IIHCDLKP DYRK_Dyrk2_DYRK4 FELLGINLYELMKNN-------NFQGFSLSIVRRFTLSVLKCLQMLSVEK--IIHCDLKP DYRK_HIPK_HIPK1 FEMLEQNLYDFLKQN-------KFSPLPLKYIRPILQQVATALMKLKSLG--LIHADLKP DYRK_HIPK_HIPK2 FEMLEQNLYDFLKQN-------KFSPLPLKYIRPVLQQVATALMKLKSLG--LIHADLKP DYRK_HIPK_HIPK3 FEMLEQNLYDFLKQN-------KFSPLPLKVIRPILQQVATALKKLKSLG--LIHADLKP DYRK_HIPK_HIPK4 FELLEQNLFEFQKEN-------NFAPLPARHIRTVTLQVLTALARLKELA--IIHADLKP DYRK_PRP4_PRP4 FEPLSMNLREVLKKYG------KDVGLHIKAVRSYSQQLFLALKLLKRCN--ILHADIKP * * * CDKL__CDKL2 ENILVS-----------------------------------------------------Q CDKL__CDKL3 ENILVS-----------------------------------------------------Q CDKL__CDKL1 ENILIT-----------------------------------------------------K CDKL__CDKL4 ENILIT-----------------------------------------------------K CDKL__CDKL5 ENLLIS-----------------------------------------------------H CDK_CDK7_CDK7 NNLLLD-----------------------------------------------------E CDK__CCRK ANLLIS-----------------------------------------------------A CDK_CDK10_CDK10 SNLLMT-----------------------------------------------------D CDK_PITSLRE_PITSLRE SNLLLS-----------------------------------------------------H CDK_CRK7_CHED SNILLN-----------------------------------------------------N CDK_CRK7_CRK7 SNILLN-----------------------------------------------------N CDK_CDK9_CDK9 ANVLIT-----------------------------------------------------R CDK_CDC2_CDK2 QNLLIN-----------------------------------------------------T CDK_CDC2_CDK3 QNLLIN-----------------------------------------------------E CDK_CDC2_CDC2 QNLLID-----------------------------------------------------D CDK_CDK5_CDK5 QNLLIN-----------------------------------------------------R CDK_TAIRE_PCTAIRE1 QNLLIN-----------------------------------------------------E CDK_TAIRE_PCTAIRE2 QNLLIN-----------------------------------------------------E CDK_TAIRE_PCTAIRE3 QNLLIN-----------------------------------------------------E CDK_TAIRE_PFTAIRE1 QNLLIS-----------------------------------------------------D CDK_TAIRE_PFTAIRE2 QNLLIS-----------------------------------------------------H CDK_CDK4_CDK4 ENILVT-----------------------------------------------------S CDK_CDK4_CDK6 QNILVT-----------------------------------------------------S CDK_CDK8_CDK8 ANILVMGEGP-------------------------------------------------E CDK_CDK8_CDK11 ANILVMGEGP-------------------------------------------------E MAPK_ERK_Erk1 SNLLSN-----------------------------------------------------T MAPK_ERK_Erk2 SNLLLN-----------------------------------------------------T MAPK_ERK_Erk5 SNLLVN-----------------------------------------------------E MAPK_nmo_NLK GNLLVN-----------------------------------------------------S MAPK_JNK_JNK1 SNIVVK-----------------------------------------------------S MAPK_JNK_JNK3 SNIVVK-----------------------------------------------------S MAPK_JNK_JNK2 SNIVVK-----------------------------------------------------S MAPK_p38_p38a SNLAVN-----------------------------------------------------E MAPK_p38_p38b SNVAVN-----------------------------------------------------E MAPK_p38_p38g GNLAVN-----------------------------------------------------E MAPK_p38_p38d GNLAVN-----------------------------------------------------E MAPK_Erk7_Erk7 SNVLLD-----------------------------------------------------A MAPK_ERK_Erk3 ANLFINT----------------------------------------------------E MAPK_ERK_Erk4 ANIFIST----------------------------------------------------E RCK__MAK ENLLCMG----------------------------------------------------- RCK__ICK ENLLCMG----------------------------------------------------- RCK__MOK ENILIK------------------------------------------------------ GSK__GSK3A QNLLVDP----------------------------------------------------D GSK__GSK3B QNLLLDP----------------------------------------------------D CLK__CLK1 ENILFVQ-----------------------------------------SDYTEAYNPKIK CLK__CLK4 ENILFVK-----------------------------------------SDYVVKYNSKMK CLK__CLK2 ENILFVN-----------------------------------------SDYELTYNLEKK CLK__CLK3 ENILFVN-----------------------------------------SEFETLYNEHKS SRPK__SRPK2 ENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTAPQQKPIGKISKNKKKKLKKKQK SRPK__MSSK1 ENILLCVGDAYIRRLAAEATEWQQAGAPPPSRSIVSTAPQEVLTGKLSKNKRKKMRRKRK SRPK__SRPK1 ENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAPQPKPADKMSKNKKKKLKKKQK DYRK_Dyrk1_DYRK1B ENILLCN---------------------------------------------------PK DYRK_Dyrk1_DYRK1A ENILLCN---------------------------------------------------PK DYRK_Dyrk2_DYRK2 ENILLKQ---------------------------------------------------QG DYRK_Dyrk2_DYRK3 ENILLKH---------------------------------------------------HG DYRK_Dyrk2_DYRK4 ENIVLYQ---------------------------------------------------KG DYRK_HIPK_HIPK1 ENIMLVD---------------------------------------------------PV DYRK_HIPK_HIPK2 ENIMLVD---------------------------------------------------PS DYRK_HIPK_HIPK3 ENIMLVD---------------------------------------------------PV DYRK_HIPK_HIPK4 ENIMLVD---------------------------------------------------QT DYRK_PRP4_PRP4 DNILVNE----------------------------------------------------S *: CDKL__CDKL2 SG---------------------------------------------------------- CDKL__CDKL3 SG---------------------------------------------------------- CDKL__CDKL1 HS---------------------------------------------------------- CDKL__CDKL4 QG---------------------------------------------------------- CDKL__CDKL5 ND---------------------------------------------------------- CDK_CDK7_CDK7 NG---------------------------------------------------------- CDK__CCRK SG---------------------------------------------------------- CDK_CDK10_CDK10 KG---------------------------------------------------------- CDK_PITSLRE_PITSLRE AG---------------------------------------------------------- CDK_CRK7_CHED RG---------------------------------------------------------- CDK_CRK7_CRK7 SG---------------------------------------------------------- CDK_CDK9_CDK9 DG---------------------------------------------------------- CDK_CDC2_CDK2 EG---------------------------------------------------------- CDK_CDC2_CDK3 LG---------------------------------------------------------- CDK_CDC2_CDC2 KG---------------------------------------------------------- CDK_CDK5_CDK5 NG---------------------------------------------------------- CDK_TAIRE_PCTAIRE1 RG---------------------------------------------------------- CDK_TAIRE_PCTAIRE2 KG---------------------------------------------------------- CDK_TAIRE_PCTAIRE3 RG---------------------------------------------------------- CDK_TAIRE_PFTAIRE1 TG---------------------------------------------------------- CDK_TAIRE_PFTAIRE2 LG---------------------------------------------------------- CDK_CDK4_CDK4 GG---------------------------------------------------------- CDK_CDK4_CDK6 SG---------------------------------------------------------- CDK_CDK8_CDK8 RG---------------------------------------------------------- CDK_CDK8_CDK11 RG---------------------------------------------------------- MAPK_ERK_Erk1 TC---------------------------------------------------------- MAPK_ERK_Erk2 TC---------------------------------------------------------- MAPK_ERK_Erk5 NC---------------------------------------------------------- MAPK_nmo_NLK NC---------------------------------------------------------- MAPK_JNK_JNK1 DC---------------------------------------------------------- MAPK_JNK_JNK3 DC---------------------------------------------------------- MAPK_JNK_JNK2 DC---------------------------------------------------------- MAPK_p38_p38a DC---------------------------------------------------------- MAPK_p38_p38b DC---------------------------------------------------------- MAPK_p38_p38g DC---------------------------------------------------------- MAPK_p38_p38d DC---------------------------------------------------------- MAPK_Erk7_Erk7 NC---------------------------------------------------------- MAPK_ERK_Erk3 DL---------------------------------------------------------- MAPK_ERK_Erk4 DL---------------------------------------------------------- RCK__MAK PE---------------------------------------------------------- RCK__ICK PE---------------------------------------------------------- RCK__MOK QD---------------------------------------------------------- GSK__GSK3A TA---------------------------------------------------------- GSK__GSK3B TA---------------------------------------------------------- CLK__CLK1 RD---------------------------------------------------------- CLK__CLK4 RD---------------------------------------------------------- CLK__CLK2 RD---------------------------------------------------------- CLK__CLK3 CE---------------------------------------------------------- SRPK__SRPK2 RQAELLEKRLQEIEELEREAERKIIEENITSAAPSNDQDGEYCPEVKLKTTGLEEAAEAE SRPK__MSSK1 QQKRLLEERLRDLQRLE--------------------------------A--MEAATQAE SRPK__SRPK1 RQAELLEKRMQEIEEMEKESG----------------------PGQKRPNKQEESESPVE DYRK_Dyrk1_DYRK1B RS---------------------------------------------------------- DYRK_Dyrk1_DYRK1A RS---------------------------------------------------------- DYRK_Dyrk2_DYRK2 RS---------------------------------------------------------- DYRK_Dyrk2_DYRK3 RS---------------------------------------------------------- DYRK_Dyrk2_DYRK4 QA---------------------------------------------------------- DYRK_HIPK_HIPK1 RQP--------------------------------------------------------- DYRK_HIPK_HIPK2 RQP--------------------------------------------------------- DYRK_HIPK_HIPK3 RQP--------------------------------------------------------- DYRK_HIPK_HIPK4 RCP--------------------------------------------------------- DYRK_PRP4_PRP4 KT---------------------------------------------------------- CDKL__CDKL2 ------------------------------------------------------------ CDKL__CDKL3 ------------------------------------------------------------ CDKL__CDKL1 ------------------------------------------------------------ CDKL__CDKL4 ------------------------------------------------------------ CDKL__CDKL5 ------------------------------------------------------------ CDK_CDK7_CDK7 ------------------------------------------------------------ CDK__CCRK ------------------------------------------------------------ CDK_CDK10_CDK10 ------------------------------------------------------------ CDK_PITSLRE_PITSLRE ------------------------------------------------------------ CDK_CRK7_CHED ------------------------------------------------------------ CDK_CRK7_CRK7 ------------------------------------------------------------ CDK_CDK9_CDK9 ------------------------------------------------------------ CDK_CDC2_CDK2 ------------------------------------------------------------ CDK_CDC2_CDK3 ------------------------------------------------------------ CDK_CDC2_CDC2 ------------------------------------------------------------ CDK_CDK5_CDK5 ------------------------------------------------------------ CDK_TAIRE_PCTAIRE1 ------------------------------------------------------------ CDK_TAIRE_PCTAIRE2 ------------------------------------------------------------ CDK_TAIRE_PCTAIRE3 ------------------------------------------------------------ CDK_TAIRE_PFTAIRE1 ------------------------------------------------------------ CDK_TAIRE_PFTAIRE2 ------------------------------------------------------------ CDK_CDK4_CDK4 ------------------------------------------------------------ CDK_CDK4_CDK6 ------------------------------------------------------------ CDK_CDK8_CDK8 ------------------------------------------------------------ CDK_CDK8_CDK11 ------------------------------------------------------------ MAPK_ERK_Erk1 ------------------------------------------------------------ MAPK_ERK_Erk2 ------------------------------------------------------------ MAPK_ERK_Erk5 ------------------------------------------------------------ MAPK_nmo_NLK ------------------------------------------------------------ MAPK_JNK_JNK1 ------------------------------------------------------------ MAPK_JNK_JNK3 ------------------------------------------------------------ MAPK_JNK_JNK2 ------------------------------------------------------------ MAPK_p38_p38a ------------------------------------------------------------ MAPK_p38_p38b ------------------------------------------------------------ MAPK_p38_p38g ------------------------------------------------------------ MAPK_p38_p38d ------------------------------------------------------------ MAPK_Erk7_Erk7 ------------------------------------------------------------ MAPK_ERK_Erk3 ------------------------------------------------------------ MAPK_ERK_Erk4 ------------------------------------------------------------ RCK__MAK ------------------------------------------------------------ RCK__ICK ------------------------------------------------------------ RCK__MOK ------------------------------------------------------------ GSK__GSK3A ------------------------------------------------------------ GSK__GSK3B ------------------------------------------------------------ CLK__CLK1 ------------------------------------------------------------ CLK__CLK4 ------------------------------------------------------------ CLK__CLK2 ------------------------------------------------------------ CLK__CLK3 ------------------------------------------------------------ SRPK__SRPK2 TAKDNGEAEDQEEKEDAEKENIEKDEDDVDQELANIDPTWIESPKTNGHIENGPFSLEQQ SRPK__MSSK1 ---DSG------------------------------------------------------ SRPK__SRPK1 RPLKENPPNKMTQEKLEESSTIGQDQTLMERDTEG----------GAAEINCNGVIEVIN DYRK_Dyrk1_DYRK1B ------------------------------------------------------------ DYRK_Dyrk1_DYRK1A ------------------------------------------------------------ DYRK_Dyrk2_DYRK2 ------------------------------------------------------------ DYRK_Dyrk2_DYRK3 ------------------------------------------------------------ DYRK_Dyrk2_DYRK4 ------------------------------------------------------------ DYRK_HIPK_HIPK1 ------------------------------------------------------------ DYRK_HIPK_HIPK2 ------------------------------------------------------------ DYRK_HIPK_HIPK3 ------------------------------------------------------------ DYRK_HIPK_HIPK4 ------------------------------------------------------------ DYRK_PRP4_PRP4 ------------------------------------------------------------ CDKL__CDKL2 ------------------------------------------------------------ CDKL__CDKL3 ------------------------------------------------------------ CDKL__CDKL1 ------------------------------------------------------------ CDKL__CDKL4 ------------------------------------------------------------ CDKL__CDKL5 ------------------------------------------------------------ CDK_CDK7_CDK7 ------------------------------------------------------------ CDK__CCRK ------------------------------------------------------------ CDK_CDK10_CDK10 ------------------------------------------------------------ CDK_PITSLRE_PITSLRE ------------------------------------------------------------ CDK_CRK7_CHED ------------------------------------------------------------ CDK_CRK7_CRK7 ------------------------------------------------------------ CDK_CDK9_CDK9 ------------------------------------------------------------ CDK_CDC2_CDK2 ------------------------------------------------------------ CDK_CDC2_CDK3 ------------------------------------------------------------ CDK_CDC2_CDC2 ------------------------------------------------------------ CDK_CDK5_CDK5 ------------------------------------------------------------ CDK_TAIRE_PCTAIRE1 ------------------------------------------------------------ CDK_TAIRE_PCTAIRE2 ------------------------------------------------------------ CDK_TAIRE_PCTAIRE3 ------------------------------------------------------------ CDK_TAIRE_PFTAIRE1 ------------------------------------------------------------ CDK_TAIRE_PFTAIRE2 ------------------------------------------------------------ CDK_CDK4_CDK4 ------------------------------------------------------------ CDK_CDK4_CDK6 ------------------------------------------------------------ CDK_CDK8_CDK8 ------------------------------------------------------------ CDK_CDK8_CDK11 ------------------------------------------------------------ MAPK_ERK_Erk1 ------------------------------------------------------------ MAPK_ERK_Erk2 ------------------------------------------------------------ MAPK_ERK_Erk5 ------------------------------------------------------------ MAPK_nmo_NLK ------------------------------------------------------------ MAPK_JNK_JNK1 ------------------------------------------------------------ MAPK_JNK_JNK3 ------------------------------------------------------------ MAPK_JNK_JNK2 ------------------------------------------------------------ MAPK_p38_p38a ------------------------------------------------------------ MAPK_p38_p38b ------------------------------------------------------------ MAPK_p38_p38g ------------------------------------------------------------ MAPK_p38_p38d ------------------------------------------------------------ MAPK_Erk7_Erk7 ------------------------------------------------------------ MAPK_ERK_Erk3 ------------------------------------------------------------ MAPK_ERK_Erk4 ------------------------------------------------------------ RCK__MAK ------------------------------------------------------------ RCK__ICK ------------------------------------------------------------ RCK__MOK ------------------------------------------------------------ GSK__GSK3A ------------------------------------------------------------ GSK__GSK3B ------------------------------------------------------------ CLK__CLK1 ------------------------------------------------------------ CLK__CLK4 ------------------------------------------------------------ CLK__CLK2 ------------------------------------------------------------ CLK__CLK3 ------------------------------------------------------------ SRPK__SRPK2 LDDEDDDEEDCPNPEEYNLDEPNAESDYTYSSSYEQFNGELPNGRHKIPESQFPEFSTSL SRPK__MSSK1 ----------------LRLDG-G--SGSTSSS--G-FSGSL-----------FSPASCSI SRPK__SRPK1 YTQNSNNETLRHKEDLHNANDCDVQNLNQESSFLSLPNGDSS-------TSQETDSCTPI DYRK_Dyrk1_DYRK1B ------------------------------------------------------------ DYRK_Dyrk1_DYRK1A ------------------------------------------------------------ DYRK_Dyrk2_DYRK2 ------------------------------------------------------------ DYRK_Dyrk2_DYRK3 ------------------------------------------------------------ DYRK_Dyrk2_DYRK4 ------------------------------------------------------------ DYRK_HIPK_HIPK1 ------------------------------------------------------------ DYRK_HIPK_HIPK2 ------------------------------------------------------------ DYRK_HIPK_HIPK3 ------------------------------------------------------------ DYRK_HIPK_HIPK4 ------------------------------------------------------------ DYRK_PRP4_PRP4 ------------------------------------------------------------ CDKL__CDKL2 ------------------------------------------------------------ CDKL__CDKL3 ------------------------------------------------------------ CDKL__CDKL1 ------------------------------------------------------------ CDKL__CDKL4 ------------------------------------------------------------ CDKL__CDKL5 ------------------------------------------------------------ CDK_CDK7_CDK7 ------------------------------------------------------------ CDK__CCRK ------------------------------------------------------------ CDK_CDK10_CDK10 ------------------------------------------------------------ CDK_PITSLRE_PITSLRE ------------------------------------------------------------ CDK_CRK7_CHED ------------------------------------------------------------ CDK_CRK7_CRK7 ------------------------------------------------------------ CDK_CDK9_CDK9 ------------------------------------------------------------ CDK_CDC2_CDK2 ------------------------------------------------------------ CDK_CDC2_CDK3 ------------------------------------------------------------ CDK_CDC2_CDC2 ------------------------------------------------------------ CDK_CDK5_CDK5 ------------------------------------------------------------ CDK_TAIRE_PCTAIRE1 ------------------------------------------------------------ CDK_TAIRE_PCTAIRE2 ------------------------------------------------------------ CDK_TAIRE_PCTAIRE3 ------------------------------------------------------------ CDK_TAIRE_PFTAIRE1 ------------------------------------------------------------ CDK_TAIRE_PFTAIRE2 ------------------------------------------------------------ CDK_CDK4_CDK4 ------------------------------------------------------------ CDK_CDK4_CDK6 ------------------------------------------------------------ CDK_CDK8_CDK8 ------------------------------------------------------------ CDK_CDK8_CDK11 ------------------------------------------------------------ MAPK_ERK_Erk1 ------------------------------------------------------------ MAPK_ERK_Erk2 ------------------------------------------------------------ MAPK_ERK_Erk5 ------------------------------------------------------------ MAPK_nmo_NLK ------------------------------------------------------------ MAPK_JNK_JNK1 ------------------------------------------------------------ MAPK_JNK_JNK3 ------------------------------------------------------------ MAPK_JNK_JNK2 ------------------------------------------------------------ MAPK_p38_p38a ------------------------------------------------------------ MAPK_p38_p38b ------------------------------------------------------------ MAPK_p38_p38g ------------------------------------------------------------ MAPK_p38_p38d ------------------------------------------------------------ MAPK_Erk7_Erk7 ------------------------------------------------------------ MAPK_ERK_Erk3 ------------------------------------------------------------ MAPK_ERK_Erk4 ------------------------------------------------------------ RCK__MAK ------------------------------------------------------------ RCK__ICK ------------------------------------------------------------ RCK__MOK ------------------------------------------------------------ GSK__GSK3A ------------------------------------------------------------ GSK__GSK3B ------------------------------------------------------------ CLK__CLK1 ------------------------------------------E----------------- CLK__CLK4 ------------------------------------------E----------------- CLK__CLK2 ------------------------------------------E----------------- CLK__CLK3 ------------------------------------------E----------------- SRPK__SRPK2 FSGSLEPVACGSVLSEGSPLTEQEESSPSHDRSRTVSASSTGDL-------PKAKTRAAD SRPK__MSSK1 LSGSSNQRETGGLLSPSTPFG------------------------------------ASN SRPK__SRPK1 TSEVSDTMVCQSSSTVGQSFSEQHISQLQESIRAEIPCEDEQEQEHNGPLDNKGKSTAGN DYRK_Dyrk1_DYRK1B ------------------------------------------------------------ DYRK_Dyrk1_DYRK1A ------------------------------------------------------------ DYRK_Dyrk2_DYRK2 ------------------------------------------------------------ DYRK_Dyrk2_DYRK3 ------------------------------------------------------------ DYRK_Dyrk2_DYRK4 ------------------------------------------------------------ DYRK_HIPK_HIPK1 ------------------------------------------------------------ DYRK_HIPK_HIPK2 ------------------------------------------------------------ DYRK_HIPK_HIPK3 ------------------------------------------------------------ DYRK_HIPK_HIPK4 ------------------------------------------------------------ DYRK_PRP4_PRP4 ------------------------------------------------------------ CDKL__CDKL2 --------------VVKLCDFGFARTLAA-----PGEVYT---DYVATRWYRAPELLVGD CDKL__CDKL3 --------------ITKLCDFGFARTLAA-----PGDIYT---DYVATRWYRAPELVLKD CDKL__CDKL1 --------------VIKLCDFGFARLLTG-----PSDYYT---DYVATRWYRSPELLVGD CDKL__CDKL4 --------------IIKICDFGFAQILI------PGDAYT---DYVATRWYRAPELLVGD CDKL__CDKL5 --------------VLKLCDFGFARNLSE----GNNANYT---EYVATRWYRSPELLLG- CDK_CDK7_CDK7 --------------VLKLADFGLAKSFG--SP-NRA--YT---HQVVTRWYRAPELLFGA CDK__CCRK --------------QLKIADFGLARVFS--PDGSRL--YT---HQVATRWYRAPELLYGA CDK_CDK10_CDK10 --------------CVKTADFGLARAYG--VP-VKP--MT---PKVVTLWYRAPELLLGT CDK_PITSLRE_PITSLRE --------------ILKVGDFGLAREYG--SP-LKA--YT---PVVVTLWYRAPELLLGA CDK_CRK7_CHED --------------QIKLADFGLARLYS-SEE-SRP--YT---NKVITLWYRPPELLLGE CDK_CRK7_CRK7 --------------QIKLADFGLARLYN-SEE-SRP--YT---NKVITLWYRPPELLLGE CDK_CDK9_CDK9 --------------VLKLADFGLARAFSLAKN-SQPNRYT---NRVVTLWYRPPELLLGE CDK_CDC2_CDK2 --------------AIKLADFGLARAFG--VP-VRT--YT---HEVVTLWYRAPEILLGC CDK_CDC2_CDK3 --------------AIKLADFGLARAFG--VP-LRT--YT---HEVVTLWYRAPEILLGS CDK_CDC2_CDC2 --------------TIKLADFGLARAFG--IP-IRV--YT---HEVVTLWYRSPEVLLGS CDK_CDK5_CDK5 --------------ELKLADFGLARAFG--IP-VRC--YS---AEVVTLWYRPPDVLFGA CDK_TAIRE_PCTAIRE1 --------------ELKLADFGLARAKS--IP-TKT--YS---NEVVTLWYRPPDILLGS CDK_TAIRE_PCTAIRE2 --------------ELKLADFGLARAKS--VP-TKT--YS---NEVVTLWYRPPDVLLGS CDK_TAIRE_PCTAIRE3 --------------ELKLADFGLARAKS--VP-TKT--YS---NEVVTLWYRPPDVLLGS CDK_TAIRE_PFTAIRE1 --------------ELKLADFGLARAKS--VP-SHT--YS---NEVVTLWYRPPDVLLGS CDK_TAIRE_PFTAIRE2 --------------ELKLADFGLARAKS--IP-SQT--YS---SEVVTLWYRPPDALLGA CDK_CDK4_CDK4 --------------TVKLADFGLARIYS--Y--QMA--LT---PVVVTLWYRAPEVLLQS CDK_CDK4_CDK6 --------------QIKLADFGLARIYS--F--QMA--LT---SVVVTLWYRAPEVLLQS CDK_CDK8_CDK8 --------------RVKIADMGFARLFN--SP-LKP--LADLDPVVVTFWYRAPELLLGA CDK_CDK8_CDK11 --------------RVKIADMGFARLFN--SP-LKP--LADLDPVVVTFWYRAPELLLGA MAPK_ERK_Erk1 --------------DLKICDFGLAR-I-ADPEHDHTGFLT---EYVATRWYRAPEIMLNS MAPK_ERK_Erk2 --------------DLKICDFGLAR-V-ADPDHDHTGFLT---EYVATRWYRAPEIMLNS MAPK_ERK_Erk5 --------------ELKIGDFGMARGL-CTSPAEHQYFMT---EYVATRWYRAPELMLSL MAPK_nmo_NLK --------------VLKICDFGLAR----VEELDESRHMT---QEVVTQYYRAPEILMGS MAPK_JNK_JNK1 --------------TLKILDFGLAR------TAGTSFMMT---PYVVTRYYRAPEVILG- MAPK_JNK_JNK3 --------------TLKILDFGLAR------TAGTSFMMT---PYVVTRYYRAPEVILG- MAPK_JNK_JNK2 --------------TLKILDFGLAR------TACTNFMMT---PYVVTRYYRAPEVILG- MAPK_p38_p38a --------------ELKILDFGLAR------HTDD--EMT---GYVATRWYRAPEIMLNW MAPK_p38_p38b --------------ELRILDFGLAR------QADE--EMT---GYVATRWYRAPEIMLNW MAPK_p38_p38g --------------ELKILDFGLAR------QADS--EMT---GYVVTRWYRAPEVILNW MAPK_p38_p38d --------------ELKILDFGLAR------HADA--EMT---GYVVTRWYRAPEVILSW MAPK_Erk7_Erk7 --------------TVKLCDFGLARSLGDLPEGPEDQAVT---EYVATRWYRAPEVLLSS MAPK_ERK_Erk3 --------------VLKIGDFGLAR--IMDPHYSHKGHLS---EGLVTKWYRSPRLLLSP MAPK_ERK_Erk4 --------------VLKIGDFGLAR--IVDQHYSHKGYLS---EGLVTKWYRSPRLLLSP RCK__MAK --------------LVKIADFGLAR------ELRSQPPYT---DYVSTRWYRAPEVLLRS RCK__ICK --------------LVKIADFGLAR------EIRSKPPYT---DYVSTRWYRAPEVLLRS RCK__MOK --------------VLKLGDFGSCR------SVYSKQPYT---EYISTRWYRAPECLLTD GSK__GSK3A --------------VLKLCDFGSAKQLVR-----GEPNVS----YICSRYYRAPELIFGA GSK__GSK3B --------------VLKLCDFGSAKQLVR-----GEPNVS----YICSRYYRAPELIFGA CLK__CLK1 --------RTLINPDIKVVDFGSATYDDEH--------HS---TLVSTRHYRAPEVILAL CLK__CLK4 --------RTLKNTDIKVVDFGSATYDDEH--------HS---TLVSTRHYRAPEVILAL CLK__CLK2 --------RSVKSTAVRVVDFGSATFDHEH--------HS---TIVSTRHYRAPEVILEL CLK__CLK3 --------KSVKNTSIRVADFGSATFDHEH--------HT---TIVATRHYRPPEVILEL SRPK__SRPK2 LLVNPLDPRNADKIRVKIADLGNACWVHKH--------FT---EDIQTRQYRSIEVLIGA SRPK__MSSK1 LLVNPLEPQNADKIKIKIADLGNACWVHKH--------FT---EDIQTRQYRAVEVLIGA SRPK__SRPK1 FLVNPLEPKNAEKLKVKIADLGNACWVHKH--------FT---EDIQTRQYRSLEVLIGS DYRK_Dyrk1_DYRK1B --------------AIKIVDFGSSCQLGQR--------IY---QYIQSRFYRSPEVLLGT DYRK_Dyrk1_DYRK1A --------------AIKIVDFGSSCQLGQR--------IY---QYIQSRFYRSPEVLLGM DYRK_Dyrk2_DYRK2 --------------GIKVIDFGSSCYEHQR--------VY---TYIQSRFYRAPEVILGA DYRK_Dyrk2_DYRK3 --------------STKVIDFGSSCFEYQK--------LY---TYIQSRFYRAPEIILGS DYRK_Dyrk2_DYRK4 --------------SVKVIDFGSSCYEHQK--------VY---TYIQSRFYRSPEVILGH DYRK_HIPK_HIPK1 -----Y--------RVKVIDFGSASHVSKA-------VCS---TYLQSRYYRAPEIILGL DYRK_HIPK_HIPK2 -----Y--------RVKVIDFGSASHVSKA-------VCS---TYLQSRYYRAPEIILGL DYRK_HIPK_HIPK3 -----Y--------RVKVIDFGSASHVSKT-------VCS---TYLQSRYYRAPEIILGL DYRK_HIPK_HIPK4 -----F--------RVKVIDFGSASIFSEVRY-----VKE---PYIQSRFYRAPEILLGL DYRK_PRP4_PRP4 --------------ILKLCDFGSASHVADN-------DIT---PYLVSRFYRAPEIIIGK : *:* . : : **. : CDKL__CDKL2 VKYGKAVDVWAIGCLVTEMFMG-EPLFPG---------DSDIDQLYHIMMCLGNLIPRHQ CDKL__CDKL3 TSYGKPVDIWALGCMIIEMATG-NPYLPS---------SSDLDLLHKIVLKVGNLSPHLQ CDKL__CDKL1 TQYGPPVDVWAIGCVFAELLSG-VPLWPG---------KSDVDQLYLIRKTLGDLIPRHQ CDKL__CDKL4 TQYGSSVDIWAIGCVFAELLTG-QPLWPG---------KSDVDQLYLIIRTLGKLIPRHQ CDKL__CDKL5 APYGKSVDMWSVGCILGELSDG-QPLFPG---------ESEIDQLFTIQKVLGPLPSEQM CDK_CDK7_CDK7 RMYGVGVDMWAVGCILAELLLR-VPFLPG---------DSDLDQLTRIFETLGTPTEEQW CDK__CCRK RQYDQGVDLWSVGCIMGELLNG-SPLFPG---------KNDIEQLCYVLRILGTPNPQVW CDK_CDK10_CDK10 TTQTTSIDMWAVGCILAELLAH-RPLLPG---------TSEIHQIDLIVQLLGTPSENIW CDK_PITSLRE_PITSLRE KEYSTAVDMWSVGCIFGELLTQ-KPLFPG---------KSEIDQINKVFKDLGTPSEKIW CDK_CRK7_CHED ERYTPAIDVWSCGCILGELFTK-KPIFQA---------NQELAQLELISRICGSPCPAVW CDK_CRK7_CRK7 ERYTPAIDVWSCGCILGELFTK-KPIFQA---------NLELAQLELISRLCGSPCPAVW CDK_CDK9_CDK9 RDYGPPIDLWGAGCIMAEMWTR-SPIMQA---------NTEQHQLALISQLCGSITPEVW CDK_CDC2_CDK2 KYYSTAVDIWSLGCIFAEMVTR-RALFPG---------DSEIDQLFRIFRTLGTPDEVVW CDK_CDC2_CDK3 KFYTTAVDIWSIGCIFAEMVTR-KALFPG---------DSEIDQLFRIFRMLGTPSEDTW CDK_CDC2_CDC2 ARYSTPVDIWSIGTIFAELATK-KPLFHG---------DSEIDQLFRIFRALGTPNNEVW CDK_CDK5_CDK5 KLYSTSIDMWSAGCIFAELANAGRPLFPG---------NDVDDQLKRIFRLLGTPTEEQW CDK_TAIRE_PCTAIRE1 TDYSTQIDMWGVGCIFYEMATG-RPLFPG---------STVEEQLHFIFRILGTPTEETW CDK_TAIRE_PCTAIRE2 SEYLTQIDMWGVGCIFFEMASG-RPLFPG---------STVEDELHLIFRLLGTPSQETW CDK_TAIRE_PCTAIRE3 TEYSTPIDMWGVGCIHYEMATG-RPLFPG---------STVKEELHLIFRLLGTPTEETW CDK_TAIRE_PFTAIRE1 TEYSTCLDMWGVGCIFVEMIQG-VAAFPGM--------KDIQDQLERIFLVLGTPNEDTW CDK_TAIRE_PFTAIRE2 TEYSSELDIWGAGCIFIEMFQG-QPLFPGV--------SNILEQLEKIWEVLGVPTEDTW CDK_CDK4_CDK4 T-YATPVDMWSVGCIFAEMFRR-KPLFCG---------NSEADQLGKIFDLIGLPPEDDW CDK_CDK4_CDK6 S-YATPVDLWSVGCIFAEMFRR-KPLFRG---------SSDVDQLGKILDVIGLPGEEDW CDK_CDK8_CDK8 RHYTKAIDIWAIGCIFAELLTS-EPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPADKDW CDK_CDK8_CDK11 RHYTKAIDIWAIGCIFAELLTS-EPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDW MAPK_ERK_Erk1 KGYTKSIDIWSVGCILAEMLSN-RPIFPG---------KHYLDQLNHILGILGSPSQEDL MAPK_ERK_Erk2 KGYTKSIDIWSVGCILAEMLSN-RPIFPG---------KHYLDQLNHILGILGSPSQEDL MAPK_ERK_Erk5 HEYTQAIDLWSVGCIFGEMLAR-RQLFPG---------KNYVHQLQLIMMVLGTPSPAVI MAPK_nmo_NLK RHYSNAIDIWSVGCIFAELLGR-RILFQA---------QSPIQQLDLITDLLGTPSLEAM MAPK_JNK_JNK1 MGYKENVDLWSVGCIMGEMVCH-KILFPG---------RDYIDQWNKVIEQLGTPCPEFM MAPK_JNK_JNK3 MGYKENVDIWSVGCIMGEMVRH-KILFPG---------RDYIDQWNKVIEQLGTPCPEFM MAPK_JNK_JNK2 MGYKENVDIWSVGCIMGELVKG-CVIFQG---------TDHIDQWNKVIEQLGTPSAEFM MAPK_p38_p38a MHYNQTVDIWSVGCIMAELLTG-RTLFPG---------TDHINQLQQIMRLTGTPPAYLI MAPK_p38_p38b MHYNQTVDIWSVGCIMAELLQG-KALFPG---------SDYIDQLKRIMEVVGTPSPEVL MAPK_p38_p38g MRYTQTVDIWSVGCIMAEMITG-KTLFKG---------SDHLDQLKEIMKVTGTPPAEFV MAPK_p38_p38d MHYNQTVDIWSVGCIMAEMLTG-KTLFKG---------KDYLDQLTQILKVTGVPGTEFV MAPK_Erk7_Erk7 HRYTLGVDMWSLGCILGEMLRG-RPLFPG---------TSTLHQLELILETIPPPSEEDL MAPK_ERK_Erk3 NNYTKAIDMWAAGCIFAEMLTG-KTLFAG---------AHELEQMQLILESIPVVHEEDR MAPK_ERK_Erk4 NNYTKAIDMWAAGCILAEMLTG-RMLFAG---------AHELEQMQLILETIPVIREEDK RCK__MAK SVYSSPIDVWAVGSIMAELYML-RPLFPG---------TSEVDEIFKICQVLGTPKKSDW RCK__ICK TNYSSPIDVWAVGCIMAEVYTL-RPLFPG---------ASEIDTIFKICQVLGTPKKTDW RCK__MOK GFYTYKMDLWSAGCVFYEIASL-QPLFPG---------VNELDQISKIHDVIGTPAQKIL GSK__GSK3A TDYTSSIDVWSAGCVLAELLLG-QPIFPG---------DSGVDQLVEIIKVLGTPTREQI GSK__GSK3B TDYTSSIDVWSAGCVLAELLLG-QPIFPG---------DSGVDQLVEIIKVLGTPTREQI CLK__CLK1 G-WSQPCDVWSIGCILIEYYLG-FTVFPTHD---------SKEHLAMMERILGPLPKHMI CLK__CLK4 G-WSQPCDVWSIGCILIEYYLG-FTVFQTHD---------SKEHLAMMERILGPIPQHMI CLK__CLK2 G-WSQPCDVWSIGCIIFEYYVG-FTLFQTHD---------NREHLAMMERILGPIPSRMI CLK__CLK3 G-WAQPCDVWSIGCILFEYYRG-FTLFQTHE---------NREHLVMMEKILGPIPSHMI SRPK__SRPK2 G-YSTPADIWSTACMAFELATG-DYLFEPHSGE---DYSRDEDHIAHIIELLGSIPRHFA SRPK__MSSK1 E-YGPPADIWSTACMAFELATG-DYLFEPHSGE---DYSRDEDHIAHIVELLGDIPPAFA SRPK__SRPK1 G-YNTPADIWSTACMAFELATG-DYLFEPHSGE---EYTRDEDHIALIIELLGKVPRKLI DYRK_Dyrk1_DYRK1B P-YDLAIDMWSLGCILVEMHTG-EPLFSGSN---------EVDQMNRIVEVLGIPPAAML DYRK_Dyrk1_DYRK1A P-YDLAIDMWSLGCILVEMHTG-EPLFSGAN---------EVDQMNKIVEVLGIPPAHIL DYRK_Dyrk2_DYRK2 R-YGMPIDMWSLGCILAELLTG-YPLLPGED---------EGDQLACMIELLGMPSQKLL DYRK_Dyrk2_DYRK3 R-YSTPIDIWSFRCILAELLTG-QPLFPGED---------EGDQLACMMELLGMPPPKLL DYRK_Dyrk2_DYRK4 P-YDVAIDMWSLGCITAELYTG-YPLFPGEN---------EVEQLACIMEVLGLPPAGFI DYRK_HIPK_HIPK1 P-FCEAIDMWSLGCVIAELFLG-WPLYPGAS---------EYDQIRYISQTQGLPAEYLL DYRK_HIPK_HIPK2 P-FCEAIDMWSLGCVIAELFLG-WPLYPGDS---------EYDQIRYISQTQGLPAEYLL DYRK_HIPK_HIPK3 P-FCEAIDMWSLGCVIAELFLG-WPLYPGAL---------EYDQIRYISQTQGLPGEQLL DYRK_HIPK_HIPK4 P-FCEKVDVWSLGCVMAELHLG-WPLYPGNN---------EYDQVRYICETQGLPKPHLL DYRK_PRP4_PRP4 S-YDYGIDMWSVGCTLYELYTG-KILFPGKT---------NNHMLKLAMDLKGKMPNKMI *:*. * CDKL__CDKL2 ELFNKNPVFAG-------VRLPEIKERE----------------------------PLER CDKL__CDKL3 NIFSKSPIFAG-------VVLPQVQHPK----------------------------NARK CDKL__CDKL1 QVFSTNQYFSG-------VKIPDPEDME----------------------------PLEL CDKL__CDKL4 SIFKSNGFFHG-------ISIPEPEDME----------------------------TLEE CDKL__CDKL5 KLFYSNPRFHG-------LRFPAVNHPQ----------------------------SLER CDK_CDK7_CDK7 PDMCSLPDY---------VTFKSFPGI-----------------------------PLHH CDK__CCRK PELTELPDYN-------KISFKEQVPM-----------------------------PLEE CDK_CDK10_CDK10 PGFSKLPLV-------GQYSLRKQPYNN----------------------------LKHK CDK_PITSLRE_PITSLRE PGYSELPAV-------KKMTFSEHPYNN----------------------------LRKR CDK_CRK7_CHED PDVIKLPYF-------NTMKPKKQYRRK----------------------------LREE CDK_CRK7_CRK7 PDVIKLPYF-------NTMKPKKQYRRR----------------------------LREE CDK_CDK9_CDK9 PNVDNYELY-------EKLELVKGQKRK----------------------------VKDR CDK_CDC2_CDK2 PGVTSMPDY-------KPS-FPKWARQ-----------------------------DFSK CDK_CDC2_CDK3 PGVTQLPDY-------KGS-FPKWTRK-----------------------------GLEE CDK_CDC2_CDC2 PEVESLQDY-------KNT-FPKWKPG-----------------------------SLAS CDK_CDK5_CDK5 PSMTKLPDY-------KP--YPMYPATT----------------------------SLVN CDK_TAIRE_PCTAIRE1 PGILSNEEF-------KTYNYPKYRAE-----------------------------ALLS CDK_TAIRE_PCTAIRE2 PGISSNEEF-------KNYNFPKYKPE-----------------------------PLIN CDK_TAIRE_PCTAIRE3 PGVTAFSEF-------RTYSFPCYLPQ-----------------------------PLIN CDK_TAIRE_PFTAIRE1 PGVHSLPHF-------KPERFTLYSSK-----------------------------NLRQ CDK_TAIRE_PFTAIRE2 PGVSKLPNY-------NPEWFPLPTPR-----------------------------SLHV CDK_CDK4_CDK4 PRDVSLP---------RGA-FPPRGPR-----------------------------PVQS CDK_CDK4_CDK6 PRDVALP---------RQA-FHSKSAQ-----------------------------PIEK CDK_CDK8_CDK8 EDIKKMPEHSTLMKDFRRNTYTNCSLIK----------------------------YMEK CDK_CDK8_CDK11 EDIRKMPEYPTLQKDFRRTTYANSSLIK----------------------------YMEK MAPK_ERK_Erk1 NCIINMKAR-------NYLQSLPSKTK----------------------------VAWAK MAPK_ERK_Erk2 NCIINLKAR-------NYLLSLPHKNK----------------------------VPWNR MAPK_ERK_Erk5 QAVGAERVR-------AYIQSLPPRQP----------------------------VPWET MAPK_nmo_NLK R-TACEGAK-------AHILRGPHKQPSL--------------------------PVLYT MAPK_JNK_JNK1 KKLQP-TVR-------TYVENRPKYAG----------------------------YSFEK MAPK_JNK_JNK3 KKLQP-TVR-------NYVENRPKYAG----------------------------LTFPK MAPK_JNK_JNK2 KKLQP-TVR-------NYVENRPKYPG----------------------------IKFEE MAPK_p38_p38a NRMPSHEAR-------NYIQSLTQMPK----------------------------MNFAN MAPK_p38_p38b AKISSEHAR-------TYIQSLPPMPQ----------------------------KDLSS MAPK_p38_p38g QRLQSDEAK-------NYMKGLPELEK----------------------------KDFAS MAPK_p38_p38d QKLNDKAAK-------SYIQSLPQTPR----------------------------KDFTQ MAPK_Erk7_Erk7 LALGSGCRA-------SVLHQLGSRPR----------------------------QTLDA MAPK_ERK_Erk3 QELLS-VIP-------VYIRNDMTEPH----------------------------KPLTQ MAPK_ERK_Erk4 DELLR-VMP-------SFVS-STWEVK----------------------------RPLRK RCK__MAK PEGYQLASS-------MNFRFPQCVPI-----------------------------NLKT RCK__ICK PEGYQLSSA-------MNFRWPQCVPN-----------------------------NLKT RCK__MOK TK-FKQSRA-------MNFDFPFKKGS-----------------------------GIPL GSK__GSK3A REMNP--NYT-------EFKFPQIKAH-----------------------------PWTK GSK__GSK3B REMNP--NYT-------EFKFPQIKAH-----------------------------PWTK CLK__CLK1 QKTRKRKYFHHDRLDWDEHSSAGRYVS----------------------------RACKP CLK__CLK4 QKTRKRKYFHHNQLDWDEHSSAGRYVR----------------------------RRCKP CLK__CLK2 RKTRKQKYFYRGRLDWDENTSAGRYVR----------------------------ENCKP CLK__CLK3 HRTRKQKYFYKGGLVWDENSSDGRYVK----------------------------ENCKP SRPK__SRPK2 LSGKYSREFFNRRGELRHITKLKPWS------------------------------LFDV SRPK__MSSK1 LSGRYSREFFNRRGELRHIHNLKHWG------------------------------LYEV SRPK__SRPK1 VAGKYSKEFFTKKGDLKHITKLKPWG------------------------------LFEV DYRK_Dyrk1_DYRK1B DQAPKARKYFERLP--GGGWTLRRTK---ELRKDYQGPGTRR-LQEVLGVQTG--GPGGR DYRK_Dyrk1_DYRK1A DQAPKARKFFEKLP--DGTWNLKKTK---DGKREYKPPGTRK-LHNILGVETG--GPGGR DYRK_Dyrk2_DYRK2 DASKRAKNFVSSK---GYPRYCTVTT---LSDGSVVLNGGR----SRRGKLRG--PPESR DYRK_Dyrk2_DYRK3 EQSKRAKYFINSK---GIPRYCSVTT---QADGRVVLVGGR----SRRGKKRG--PPGSK DYRK_Dyrk2_DYRK4 QTASRRQTFFDSK---GFPKNITNN----------------------RGKKR---YPDSK DYRK_HIPK_HIPK1 SAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDL DYRK_HIPK_HIPK2 SAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDL DYRK_HIPK_HIPK3 NVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTVMDL DYRK_HIPK_HIPK4 HAACKAHHFF-------------------------------------------------- DYRK_PRP4_PRP4 RKGVFKDQHFDQNLNFMYIEVDKVTER------------------EKVTVMSTINPTKDL CDKL__CDKL2 RYP------------KLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFF CDKL__CDKL3 KYP------------KLNGLLADIVHACLQIDPADRISSSDLLHHEYF CDKL__CDKL1 KFP------------NISYPALGLLKGCLHMDPTERLTCEQLLHHPYF CDKL__CDKL4 KFS------------DVHPVALNFMKGCLKMNPDDRLTCSQLLESSYF CDKL__CDKL5 RYLG-----------ILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTF CDK_CDK7_CDK7 IFSAAG------------DDLLDLIQGLFLFNPCARITATQALKMKYF CDK__CCRK VLPDVS------------PQALDLLGQFLLYPPHQRIAASKALLHQYF CDK_CDK10_CDK10 F-PWLS------------EAGLRLLHFLFMYDPKKRATAGDCLESSYF CDK_PITSLRE_PITSLRE FGALLS------------DQGFDLMNKFLTYFPGRRISAEDGLKHEYF CDK_CRK7_CHED FVFIP-------------AAALDLFDYMLALDPSKRCTAEQALQCEFL CDK_CRK7_CRK7 FSFIP-------------SAALDLLDHMLTLDPSKRCTAEQTLQSDFL CDK_CDK9_CDK9 LKAYVRD-----------PYALDLIDKLLVLDPAQRIDSDDALNHDFF CDK_CDC2_CDK2 VVPPLD------------EDGRSLLSQMLHYDPNKRISAKAALAHPFF CDK_CDC2_CDK3 IVPNLE------------PEGRDLLMQLLQYDPSQRITAKTALAHPYF CDK_CDC2_CDC2 HVKNLD------------ENGLDLLSKMLIYDPAKRISGKMALNHPYF CDK_CDK5_CDK5 VVPKLN------------ATGRDLLQNLLKCNPVQRISAEEALQHPYF CDK_TAIRE_PCTAIRE1 HAPRLD------------SDGADLLTKLLQFEGRNRISAEDAMKHPFF CDK_TAIRE_PCTAIRE2 HAPRLD------------SEGIELIRKFLQYESKKRVSAEEAMKHVYF CDK_TAIRE_PCTAIRE3 HAPRLD------------TDGIHLLSSLLLYESKSRMSAEAALSHSYF CDK_TAIRE_PFTAIRE1 AWNKLSYV----------NHAEDLASKLLQCSPKNRLSAQAALSHEYF CDK_TAIRE_PFTAIRE2 VWNRLGRV----------PEAEDLASQMLKGFPRDRVSAQEALVHDYF CDK_CDK4_CDK4 VVPEME------------ESGAQLLLEMLTFNPHKRISAFRALQHSYL CDK_CDK4_CDK6 FVTDID------------ELGKDLLLKCLTFNPAKRISAYSALSHPYF CDK_CDK8_CDK8 HKVKPD------------SKAFHLLQKLLTMDPIKRITSEQAMQDPYF CDK_CDK8_CDK11 HKVKPD------------SKVFLLLQKLLTMDPTKRITSEQALQDPYF MAPK_ERK_Erk1 LFPK------------SDSKALDLLDRMLTFNPNKRITVEEALAHPYL MAPK_ERK_Erk2 LFPN------------ADSKALDLLDKMLTFNPHKRIEVEQALAHPYL MAPK_ERK_Erk5 VYPG------------ADRQALSLLGRMLRFEPSARISAAAALRHPFL MAPK_nmo_NLK LSSQ------------ATHEAVHLLCRMLVFDPSKRISAKDALAHPYL MAPK_JNK_JNK1 LFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYI MAPK_JNK_JNK3 LFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI MAPK_JNK_JNK2 LFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYI MAPK_p38_p38a VFIG------------ANPLAVDLLEKMLVLDSDKRITAAQALAHAYF MAPK_p38_p38b IFRG------------ANPLAIDLLGRMLVLDSDQRVSAAEALAHAYF MAPK_p38_p38g ILTN------------ASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF MAPK_p38_p38d LFPR------------ASPQAADLLEKMLELDVDKRLTAAQALTHPFF MAPK_Erk7_Erk7 LLPP-----------DTSPEALDLLRRLLVFAPDKRLSATQALQHPYV MAPK_ERK_Erk3 LLPG------------ISREALDFLEQILTFSPMDRLTAEEALSHPYM MAPK_ERK_Erk4 LLPE------------VNSEAIDFLEKILTFNPMDRLTAEMGLQHPYM RCK__MAK LIPNAS------------NEAIQLMTEMLNWDPKKRPTASQALKHPYF RCK__ICK LIPNAS------------SEAVQLLRDMLQWDPKKRPTASQALRYPYF RCK__MOK LTTNLS------------PQCLSLLHAMVAYDPDERIAAHQALQHPYF GSK__GSK3A VFKSRTP-----------PEAIALCSSLLEYTPSSRLSPLEACAHSFF GSK__GSK3B VFRPRTP-----------PEAIALCSRLLEYTPTARLTPLEACAHSFF CLK__CLK1 LKEFM------LSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFF CLK__CLK4 LKEFM------LCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFF CLK__CLK2 LRRYL------TSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFF CLK__CLK3 LKSYM------LQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFF SRPK__SRPK2 LVEKY------GWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWL SRPK__MSSK1 LMEKY------EWPLEQATQFSAFLLPMMEYIPEKRASAADCLQHPWL SRPK__SRPK1 LVEKY------EWSQEEAAGFTDFLLPMLELIPEKRATAAECLRHPWL DYRK_Dyrk1_DYRK1B RAGEP------GHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFF DYRK_Dyrk1_DYRK1A RAGES------GHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF DYRK_Dyrk2_DYRK2 EWGNA------LKGCDDPL-FLDFLKQCLEWDPAVRMTPGQALRHPWL DYRK_Dyrk2_DYRK3 DWGTA------LKGCDDYL-FIEFLKRCLHWDPSARLTPAQALRHPWI DYRK_Dyrk2_DYRK4 DLTMV------LKTYDTS--FLDFLRRCLVWEPSLRMTPDQALKHAWI DYRK_HIPK_HIPK1 EGTDM------LAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFV DYRK_HIPK_HIPK2 EGSDM------LVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFV DYRK_HIPK_HIPK3 EGSDL------LAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFV DYRK_HIPK_HIPK4 -------------------------KRMLTWESHERISPSAALRHPFV DYRK_PRP4_PRP4 LADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQ---- . *