CLUSTAL W (1.8) multiple sequence alignment STE11__MAP3K2 -----WRLGKLLGQGAFG--RVYLCYDVDTGRELAVKQVQFDP------- STE11__MAP3K3 -----WRRGKLLGQGAFG--RVYLCYDVDTGRELASKQVQFDP------- STE11__MAP3K8 -----WTKGEILGKGAYG--TVY-CGLTSQGQLIAVKQVALDTS------ STE11__MAP3K1 -----WLKGQQIGLGAFS--SCYQAQDVGTGTLMAVKQVTYVRN------ STE11__MAP3K5 YEYDENGDRVVLGKGTYG--IVYAGRDLSNQVRIAIKEIPER-------- STE11__MAP3K7 -------ERVVLGKGTYG--IVYAGRDLSNQVRIAIKEIPER-------- STE11__MAP3K6 ----------VLGKGTYG--VVYAGRDRHTRVRIAIKEIPER-------- STE11__MAP3K4 -----WQRGNKIGEGQYG--KVYTCISVDTGELMAMKEIRFQP------- STE20_MST_MST1 -----FDVLEKLGEGSYG--SVYKAIHKETGQIVAIKQVPVES------- STE20_MST_MST2 -----FDVLEKLGEGSYG--SVFKAIHKESGQVVAIKQVPVES------- STE20_YSK_MST3 -----FTKLEKIGKGSFG--EVFKGIDNRTQKVVAIKIIDLEEA------ STE20_YSK_YSK1 -----FTKLDRIGKGSFG--EVYKGIDNHTKEVVAIKIIDLEEA------ STE20_YSK_MST4 -----FTKLQRIGKGSFG--EVFKGIDNRTQQVVAIKIIDLEEA------ STE20_KHS_KHS1 -----YELVQRVGSGTYG--DVYKARNVHTGELAAVKIIKLEP------- STE20_KHS_KHS2 -----FELIQRIGSGTYG--DVYKARNVNTGELAAIKVIKLEP------- STE20_KHS_GCK -----FELLQRVGAGTYG--DVYKARDTVTSELAAVKIVKLDP------- STE20_KHS_HPK1 -----YDLLQRLGGGTYG--EVFKARDKVSGDLVALKMVKMEP------- STE20_SLK_SLK -----WEIIGELGDGAFG--KVYKAQNKETSVLAAAKVIDTKS------- STE20_SLK_LOK -----WEIVGELGDGAFG--KVYKAKNKETGALAAAKVIETKS------- STE20_MSN_ZC1/HGK -----FELVEVVGNGTYG--QVYKGRHVKTGQLAAIKVMDVTE------- STE20_MSN_ZC3/MINK -----FELVEVVGNGTYG--QVYKGRHVKTGQLAAIKVMDVTE------- STE20_MSN_ZC2/TNIK -----FELVELVGNGTYG--QVYKGRHVKTGQLAAIKVMDVTG------- STE20_MSN_ZC4/NRK -----FSLDKTIGLGTYG--RIYLGLHEKTGAFTAVKVMNARKTPLPEIG STE20_NinaC_MYO3B -----WEIIETIGKGTYG--KVYKVTNKRDGSLAAVKILDPVS------- STE20_NinaC_MYO3A -----WEITETIGKGTYG--KVFKVLNKKNGQKAAVKILDPIH------- STE20_TAO_TAO2 -----FSDLREIGHGSFG--AVYFARDVRNSEVVAIKKMSYSGK------ STE20_TAO_TAO1 -----FTDLREIGHGSFG--AVYFARDVRTNEVVAIKKMSYSGK------ STE20_TAO_TAO3 -----FIGLHEIGHGSFG--AVYFATNAHTNEVVAIKKMSYSGK------ STE20_PAKA_PAK1 -----YTRFEKIGQGASG--TVYTAMDVATGQEVAIKQMNLQQ------- STE20_PAKA_PAK3 -----YTRFEKIGQGASG--TVYTALDIATGQEVAIKQMNLQQ------- STE20_PAKA_PAK2 -----YTRYEKIGQGASG--TVFTATDVALGQEVAIKQINLQK------- STE20_PAKB_PAK4 -----LDNFIKIGEGSTG--IVCIATVRSSGKLVAVKKMDLRK------- STE20_PAKB_PAK5 -----LANFIKIGEGSTG--IVCIATEKHTGKQVAVKKMDLRK------- STE20_PAKB_PAK6 -----LDSYVKIGEGSTG--IVCLAREKHSGRQVAVKMMDLRK------- STE20_FRAY_OSR1 -----YELQEVIGSGAT--AVVQAAYCAPKKEKVAIKRINLEKCQ----- STE20_FRAY_STLK3 -----YELQEVIGSGAT--AVVQAALCKPRQERVAIKRINLEKCQ----- STE20_STLK_STLK5 -----YELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACS----- STE20_STLK_STLK6 -----YELQVEIGRGFDNLTSVHLARHTPTGTLVTIKITNLENCN----- STE-Unique__COT ---YRNIGSDFIPRGAFG--KVYLAQDIKTKKRMACKLIPVDQFK----- STE-Unique__NIK -----ATHQLRLGRGSFG--EVHRMEDKQTGFQCAVKKVRLEVFR----- STE7__MAP2K1 -----FEKISELGAGNGG--VVFKVSHKPSGLVMARKLIHLEIK------ STE7__MAP2K2 -----FERISELGAGNGG--VVTKVQHRPSGLIMARKLIHLEIK------ STE7__MAP2K5 -----IRYRDTLGHGNGG--TVYKAYHVPSGKILAVKVILLDIT------ STE7__MAP2K6 -----LEPIMELGRGAYG--VVEKMRHVPSGQIMAVKRIRATVN------ STE7__MAP2K3 -----LVTISELGRGAYG--VVEKVRHAQSGTIMAVKRIRATVN------ STE7__MAP2K4 -----LKDLGEIGRGAYG--SVNKMVHKPSGQIMAVKRIRSTVD------ STE7__MAP2K7 -----LENLGEMGSGTCG--QVWKMRFRKTGHVIAVKQMRRSGN------ STE-Unique__Domain2_GCN2 -----VHKGKCIGSDEQLGKLVYNALETATGGFVLLYEWVLQWQKKMG-- : . STE11__MAP3K2 -----------DSPETSKEVNALECEIQLLKNFL-HERIVQYYG-CLRDP STE11__MAP3K3 -----------DSPETSKEVSALECEIQLLKNLQ-HERIVQYYG-CLRDR STE11__MAP3K8 -----------NKLAAEKEYRKLQEEVDLLKALK-HVNIVAYLGTCL--- STE11__MAP3K1 -----------TSSEQEEVVEALREEIRMMSHLN-HPNIIRMLGATC--- STE11__MAP3K5 ---------------DSRYSQPLHEEIALHKHLK-HKNIVQYLGSFS--- STE11__MAP3K7 ---------------DSRYSQPLHEEIALHKYLK-HRNIVQYLGSVS--- STE11__MAP3K6 ---------------DSRFSQPLHEEIALHRRLR-HKNIVRYLGSAS--- STE11__MAP3K4 --------------NDHKTIKETADELKIFEGIK-HPNLVRYFGVEL--- STE20_MST_MST1 ------------------DLQEIIKEISIMQQCD-SPHVVKYYGSYFKNT STE20_MST_MST2 ------------------DLQEIIKEISIMQQCD-SPYVVKYYGSYFKNT STE20_YSK_MST3 ----------------EDEIEDIQQEITVLSQCD-SPYVTKYYGSYLKDT STE20_YSK_YSK1 ----------------EDEIEDIQQEITVLSQCD-SPYITRYFGSYLKST STE20_YSK_MST4 ----------------EDEIEDIQQEITVLSQCD-SSYVTKYYGSYLKGS STE20_KHS_KHS1 ----------------GDDFSLIQQEIFMVKECK-HCNIVAYFGSYLSRE STE20_KHS_KHS2 ----------------GEDFAVVQQEIIMMKDCK-HPNIVAYFGSYLRRD STE20_KHS_GCK ----------------GDDISSLQQEITILRECR-HPNVVAYIGSYLRND STE20_KHS_HPK1 ----------------DDDVSTLQKEILILKTCR-HANIVAYHGSYLWLQ STE20_SLK_SLK ----------------EEELEDYMVEIDILASCD-HPNIVKLLDAFYYEN STE20_SLK_LOK ----------------EEELEDYIVEIEILATCD-HPYIVKLLGAYYHDG STE20_MSN_ZC1/HGK -----------------DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKS STE20_MSN_ZC3/MINK -----------------DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKS STE20_MSN_ZC2/TNIK -----------------DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKN STE20_MSN_ZC4/NRK RRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLS STE20_NinaC_MYO3B -----------------DMDEEIEAEYNILQFLPNHPNVVKFYGMFYKAD STE20_NinaC_MYO3A -----------------DIDEEIEAEYNILKALSDHPNVVRFYGIYFKKD STE20_TAO_TAO2 --------------QSNEKWQDIIKEVRFLQKLR-HPNTIQYRGCYLREH STE20_TAO_TAO1 --------------QSTEKWQDIIKEVKFLQRIK-HPNSIEYKGCYLREH STE20_TAO_TAO3 --------------QTHEKWQDILKEVKFLRQLK-HPNTIEYKGCYLKEH STE20_PAKA_PAK1 ----------------QPKKELIINEILVMRENK-NPNIVNYLDSYLVGD STE20_PAKA_PAK3 ----------------QPKKELIINEILVMRENK-NPNIVNYLDSYLVGD STE20_PAKA_PAK2 ----------------QPKKELIINEILVMKELK-NPNIVNFLDSYLVGD STE20_PAKB_PAK4 ----------------QQRRELLFNEVVIMRDYQ-HENVVEMYNSYLVGD STE20_PAKB_PAK5 ----------------QQRRELLFNEVVIMRDYH-HDNVVDMYSSYLVGD STE20_PAKB_PAK6 ----------------QQRRELLFNEVVIMRDYQ-HFNVVEMYKSYLVGE STE20_FRAY_OSR1 ----------------TS-MDELLKEIQAMSQCH-HPNIVSYYTSFVVKD STE20_FRAY_STLK3 ----------------TS-MDELLKEIQAMSQCS-HPNVVTYYTSFVVKD STE20_STLK_STLK5 ----------------NEMVTFLQGELHVSKLFN-HPNIVPYRATFIADN STE20_STLK_STLK6 ----------------EERLKALQKAVILSHFFR-HPNITTYWTVFTVGS STE-Unique__COT -----------------------PSDVEIQACFR-HENIAELYGAVLWGE STE-Unique__NIK -----------------------AEELMACAGLT-SPRIVPLYGAVREGP STE7__MAP2K1 ----------------PAIRNQIIRELQVLHEC-NSPYIVGFYGAFYSDG STE7__MAP2K2 ----------------PAIRNQIIRELQVLHEC-NSPYIVGFYGAFYSDG STE7__MAP2K5 ----------------LELQKQIMSELEILYKC-DSSYIIGFYGAFFVEN STE7__MAP2K6 ----------------SQEQKRLLMDLDISMRTVDCPFTVTFYGALFREG STE7__MAP2K3 ----------------SQEQKRLLMDLDINMRTVDCFYTVTFYGALFREG STE7__MAP2K4 ----------------EKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREG STE7__MAP2K7 ----------------KEENKRILMDLDVVLKSHDCPYIVQCFGTFITNT STE-Unique__Domain2_GCN2 --PFLTSQEKEKIDKCKKQIQGTETEFNSLVKLS-HPNVVRYLAMNLKEQ STE11__MAP3K2 Q---EKTLSIFMEYMPGGSIKDQLK---AYGA-----LT--ENGTRKYTR STE11__MAP3K3 A---EKTLTIFMEYMPGGSVKDQLK---AYGA-----LT--ESVTRKYTR STE11__MAP3K8 Q---ENTVSIFMEFVPGGSISSIIN---RFGP-----LP--EMVFCKYTK STE11__MAP3K1 E---KSNYNLFIEWMAGGSVAHLLS---KYGA-----FK--ESVVINYTE STE11__MAP3K5 E---NGFIKIFMEQVPGGSLSALLRS--KWGP-----LKDNEQTIGFYTK STE11__MAP3K7 E---NGYIKIFMEQVPGGSLSALLRS--KWGP-----MK--EPTIKFYTK STE11__MAP3K6 Q---GGYLKIFMEEVPGGSLSSLLRS--VWGP-----LKDNESTISFYTR STE11__MAP3K4 H---REEMYIFMEYCDEGTLEEVSR----LG------LQ--EHVIRLYSK STE20_MST_MST1 D------LWIVMEYCGAGSVSDIIR---LRNK----TLT--EDEIATILQ STE20_MST_MST2 D------LWIVMEYCGAGSVSDIIR---LRNK----TLI--EDEIATILK STE20_YSK_MST3 K------LWIIMEYLGGGSALDLLE---PG------PLD--ETQIATILR STE20_YSK_YSK1 K------LWIIMEYLGGGSALDLLK---PG------PLE--ETYIATILR STE20_YSK_MST4 K------LWIIMEYLGGGSALDLLR---AG------PFD--EFQIATMLK STE20_KHS_KHS1 K------LWICMEYCGGGSLQDIYH---VTG-----PLS--ELQIAYVCR STE20_KHS_KHS2 K------LWICMEFCGGGSLQDIYH---VTG-----PLS--ELQIAYVSR STE20_KHS_GCK R------LWICMEFCGGGSLQEIYH---ATG-----PLE--ERQIAYVCR STE20_KHS_HPK1 K------LWICMEFCGAGSLQDIYQ---VTG-----SLS--ELQISYVCR STE20_SLK_SLK N------LWILIEFCAGGAVDAVML---ELER----PLT--ESQIQVVCK STE20_SLK_LOK K------LWIMIEFCPGGAVDAIML---ELDR----GLT--EPQIQVVCR STE20_MSN_ZC1/HGK PPGHDDQLWLVMEFCGAGSITDLVK--NTKGN----TLK--EDWIAYISR STE20_MSN_ZC3/MINK PPGNDDQLWLVMEFCGAGSVTDLVK--NTKGN----ALK--EDCIAYICR STE20_MSN_ZC2/TNIK PPGMDDQLWLVMEFCGAGSVTDLIK--NTKGN----TLK--EEWIAYICR STE20_MSN_ZC4/NRK PPGQRHQLWMVMELCAAGSVTDVVR--MTSNQ----SLK--EDWIAYICR STE20_NinaC_MYO3B H-CVGGQLWLVLELCNGGSVTELVKGLLRCGQ----RLD--EAMISYILY STE20_NinaC_MYO3A K-VNGDKLWLVLELCSGGSVTDLVKGFLKRGE----RMS--EPLIAYILH STE20_TAO_TAO2 T------AWLVMEYCLG-SASDLLE---VHKK----PLQ--EVEIAAVTH STE20_TAO_TAO1 T------AWLVMEYCLG-SASDLLE---VHKK----PLQ--EVEIAAITH STE20_TAO_TAO3 T------AWLVMEYCLG-SASDLLE---VHKK----PLQ--EVEIAAITH STE20_PAKA_PAK1 E------LWVVMEYLAGGSLTDVVT--ET-------CMD--EGQIAAVCR STE20_PAKA_PAK3 E------LWVVMEYLAGGSLTDVVT--ET-------CMD--EGQIAAVCR STE20_PAKA_PAK2 E------LFVVMEYLAGGSLTDVVT--ETA------CMD--EAQIAAVCR STE20_PAKB_PAK4 E------LWVVMEFLEGGALTDIVT--HT-------RMN--EEQIAAVCL STE20_PAKB_PAK5 E------LWVVMEFLEGGALTDIVT--HT-------RMN--EEQIATVCL STE20_PAKB_PAK6 E------LWVLMEFLQGGALTDIVS--QV-------RLN--EEQIATVCE STE20_FRAY_OSR1 E------LWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLD--ESTIATILR STE20_FRAY_STLK3 E------LWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLE--EAIIATILK STE20_STLK_STLK5 E------LWVVTSFMAYGSAKDLICTHFMDG------MN--ELAIAYILQ STE20_STLK_STLK6 W------LWVISPFMAYGSASQLLRTYFPEG------MS--ETLIRNILF STE-Unique__COT T------VHLFMEAGEGGSVLEKLE---SCG-----PMR--EFEIIWVTK STE-Unique__NIK W------VNIFMELLEGGSLGQLVK---EQG-----CLP--EDRALYYLG STE7__MAP2K1 E------ISICMEHMDGGSLDQVLK---KAGR-----IP--EQILGKVSI STE7__MAP2K2 E------ISICMEHMDGGSLDQVLK---EAKR-----IP--EEILGKVSI STE7__MAP2K5 R------ISICTEFMDGGSLDVYR-------K-----MP--EHVLGRIAV STE7__MAP2K6 D------VWICMELMDTSLDKFYKQ---VIDK--GQTIP--EDILGKIAV STE7__MAP2K3 D------VWICMELMDTSLDKFYRK---VLDK--NMTIP--EDILGEIAV STE7__MAP2K4 D------CWICMELMSTSFDKFYKY---VYSVL-DDVIP--EEILGKITL STE7__MAP2K7 D------VFIAMELMGTCAEKLKKR---MQGP-----IP--ERILGKMTV STE-Unique__Domain2_GCN2 D--DSIVVDILVEHISGVSLAAHLS---HSG-----PIP--VHQLRRYTA : : STE11__MAP3K2 QILEGVHYLHS-NMILHRDIKGANILRDSTGN-VKLGDFGASKRLQTICL STE11__MAP3K3 QILEGMSYLHS-NMIVHRDIKGANILRDSAGN-VKLGDFGASKRLQTICM STE11__MAP3K8 QILQGVAYLHE-NCVVHRDIKGNNVMLMPTGI-IKLIDFGCARRLAWAGL STE11__MAP3K1 QLLRGLSYLHE-NQIIHRDVKGANLLIDSTGQRLRIADFGAAARLASKG- STE11__MAP3K5 QILEGLKYLHD-NQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAG--- STE11__MAP3K7 QILEGLKYLHE-NQIVHRDIKGDNVLVNTYSGVVKISDFGTSKRLAG--- STE11__MAP3K6 QILQGLGYLHD-NHIVHRDIKGDNVLINTFSGLLKISDFGTSKRLAG--- STE11__MAP3K4 QITIAINVLHE-HGIVHRDIKGANIFL-TSSGLIKLGDFGCSVKLKNNAQ STE20_MST_MST1 STLKGLEYLHF-MRKIHRDIKAGNILLNTE-GHAKLADFGVAGQLTDTMA STE20_MST_MST2 STLKGLEYLHF-MRKIHRDIKAGNILLNTE-GHAKLADFGVAGQLTDTMA STE20_YSK_MST3 EILKGLDYLHS-EKKIHRDIKAANVLLSEH-GEVKLADFGVAGQLTDTQI STE20_YSK_YSK1 EILKGLDYLHS-ERKIHRDIKAANVLLSEQ-GDVKLADFGVAGQLTDTQI STE20_YSK_MST4 EILKGLDYLHS-EKKIHRDIKAANVLLSEQ-GDVKLADFGVAGQLTDTQI STE20_KHS_KHS1 ETLQGLAYLHT-KGKMHRDIKGANILLTDH-GDVKLADFGVAAKITATIA STE20_KHS_KHS2 ETLQGLYYLHS-KGKMHRDIKGANILLTDN-GHVKLADFGVSAQITATIA STE20_KHS_GCK ERLKGLHHLHS-QGKIHRDIKGANLLLTLQ-GDVKLADFGVSGELTASVA STE20_KHS_HPK1 EVLQGLAYLHS-QKKIHRDIKGANILINDA-GEVRLADFGISAQIGATLA STE20_SLK_SLK QTLDALNYLHD-NKIIHRDLKAGNILFTLD-GDIKLADFGVSAKNTRTIQ STE20_SLK_LOK QMLEALNFLHS-KRIIHRDLKAGNVLMTLE-GDIRLADFGVSAKNLKTLQ STE20_MSN_ZC1/HGK EILRGLAHLHI-HHVIHRDIKGQNVLLTEN-AEVKLVDFGVSAQLDRTVG STE20_MSN_ZC3/MINK EILRGLAHLHA-HKVIHRDIKGQNVLLTEN-AEVKLVDFGVSAQLDRTVG STE20_MSN_ZC2/TNIK EILRGLSHLHQ-HKVIHRDIKGQNVLLTEN-AEVKLVDFGVSAQLDRTVG STE20_MSN_ZC4/NRK EILQGLAHLHA-HRVIHRDIKGQNVLLTHN-AEVKLVDFGVSAQVSRTNG STE20_NinaC_MYO3B GALLGLQHLHN-NRIIHRDVKGNNILLTTE-GGVKLVDFGVSAQLTSTRL STE20_NinaC_MYO3A EALMGLQHLHN-NKTIHRDVKGNNILLTTE-GGVKLVDFGVSAQLTSTRH STE20_TAO_TAO2 GALQGLAYLHS-HNMIHRDVKAGNILLSEP-GLVKLGDFGSASIMAPA-- STE20_TAO_TAO1 GALQGLAYLHS-HTMIHRDIKAGNILLTEP-GQVKLADFGSASMASPA-- STE20_TAO_TAO3 GALHGLAYLHS-HALIHRDIKAGNILLTEP-GQVKLADFGSASMASPA-- STE20_PAKA_PAK1 ECLQALEFLHS-NQVIHRDIKSDNILLGMD-GSVKLTDFGFCAQITPEQS STE20_PAKA_PAK3 ECLQALDFLHS-NQVIHRDIKSDNILLGMD-GSVKLTDFGFCAQITPEQS STE20_PAKA_PAK2 ECLQALEFLHA-NQVIHRDIKSDNVLLGME-GSVKLTDFGFCAQITPEQS STE20_PAKB_PAK4 AVLQALSVLHA-QGVIHRDIKSDSILLTHD-GRVKLSDFGFCAQVSKEVP STE20_PAKB_PAK5 SVLRALSYLHN-QGVIHRDIKSDSILLTSD-GRIKLSDFGFCAQVSKEVP STE20_PAKB_PAK6 AVLQALAYLHA-QGVIHRDIKSDSILLTLD-GRVKLSDFGFCAQISKDVP STE20_FRAY_OSR1 EVLEGLEYLHK-NGQIHRDVKAGNILLGED-GSVQIADFGVSAFLATGGD STE20_FRAY_STLK3 EVLEGLDYLHR-NGQIHRDLKAGNILLGED-GSVQIADFGVSAFLATGGD STE20_STLK_STLK5 GVLKALDYIHH-MGYVHRSVKASHILISVD-GKVYLSGLRSNLSMISHGQ STE20_STLK_STLK6 GAVRGLNYLHQ-NGCIHRSIKASHILISGD-GLVTLSGLSHLHSLVKHGQ STE-Unique__COT HVLKGLDFLHS-KKVIHHDIKPSNIVFMS--TKAVLVDFGLSVQMTED-- STE-Unique__NIK QALEGLEYLHS-RRILHGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGL STE7__MAP2K1 AVIKGLTYLREKHKIMHRDVKPSNILVNSR-GEIKLCDFGVSGQLIDSMA STE7__MAP2K2 AVLRGLAYLREKHQIMHRDVKPSNILVNSR-GEIKLCDFGVSGQLIDSMA STE7__MAP2K5 AVVKGLTYLWS-LKILHRDVKPSNMLVNTR-GQVKLCDFGVSTQLVNSIA STE7__MAP2K6 SIVKALEHLHSKLSVIHRDVKPSNVLINAL-GQVKMCDFGISGYLVDSVA STE7__MAP2K3 SIVRALEHLHSKLSVIHRDVKPSNVLINKE-GHVKMCDFGISGYLVDSVA STE7__MAP2K4 ATVKALNHLKENLKIIHRDIKPSNILLDRS-GNIKLCDFGISGQLVDSIA STE7__MAP2K7 AIVKALYYLKEKHGVIHRDVKPSNILLDER-GQIKLCDFGISGRLVDSKA STE-Unique__Domain2_GCN2 QLLSGLDYLHS-NSVVHKVLSASNVLVDAE-GTVKITDYSISKRLADICK .: : :* :. :. : . STE11__MAP3K2 SGTG----MKSVTGTPYWMSPEVISG-----QGYGRKADIWSVACTVVEM STE11__MAP3K3 SGTG----MRSVTGTPYWMSPEVISG-----EGYGRKADVWSLGCTVVEM STE11__MAP3K8 NGTHS-DMLKSMHGTPYWMAPEVINE-----SGYGRKSDIWSIGCTVFEM STE11__MAP3K1 TGAG--EFQGQLLGTIAFMAPEVLRG-----QQYGRSCDVWSVGCAIIEM STE11__MAP3K5 -INP---CTETFTGTLQYMAPEIIDKGP---RGYGKAADIWSLGCTIIEM STE11__MAP3K7 -VNP---CTETFTGTLQYMAPEIIDQGP---RGYGAPADIWSLGCTIIEM STE11__MAP3K6 -ITP---CTETFTGTLQYMAPEIIDQGP---RGYGKAADIWSLGCTVIEM STE11__MAP3K4 TMPG---EVNSTLGTAAYMAPEVITRAKG--EGHGRAADIWSLGCVVIEM STE20_MST_MST1 K-R------NTVIGTPFWMAPEVIQEI-----GYNCVADIWSLGITAIEM STE20_MST_MST2 K-R------NTVIGTPFWMAPEVIQEI-----GYNCVADIWSLGITSIEM STE20_YSK_MST3 K-R------NTFVGTPFWMAPEVIKQS-----AYDSKADIWSLGITAIEL STE20_YSK_YSK1 K-R------NTFVGTPFWMAPEVIKQS-----AYDFKADIWSLGITAIEL STE20_YSK_MST4 K-R------NTFVGTPFWMAPEVIQQS-----AYDSKADIWSLGITAIEL STE20_KHS_KHS1 K-R------KSFIGTPYWMAPEVAAVE--KNGGYNQLCDIWAVGITAIEL STE20_KHS_KHS2 K-R------KSFIGTPYWMAPEVAAVE--RKGGYNQLCDLWAVGITAIEL STE20_KHS_GCK K-R------RSFIGTPYWMAPEVAAVE--RKGGYNELCDVWALGITAIEL STE20_KHS_HPK1 R-R------LSFIGTPYWMAPEVAAVA--LKGGYNELCDIWSLGITAIEL STE20_SLK_SLK R-R------DSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEM STE20_SLK_LOK K-R------DSFIGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEM STE20_MSN_ZC1/HGK R-R------NTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEM STE20_MSN_ZC3/MINK R-R------NTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEM STE20_MSN_ZC2/TNIK R-R------NTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEM STE20_MSN_ZC4/NRK R-R------NSFIGTPYWMAPEVIDCDEDPRRSYDYRSDVWSVGITAIEM STE20_NinaC_MYO3B R-R------NTSVGTPFWMAPEVIACEQQYDSSYDARCDVWSLGITAIEL STE20_NinaC_MYO3A R-R------NTSVGTPFWMAPEVIACEQQLDTTYDARCDTWSLGITAIEL STE20_TAO_TAO2 ---------NSFVGTPYWMAPEVILAMD--EGQYDGKVDVWSLGITCIEL STE20_TAO_TAO1 ---------NSFVGTPYWMAPEVILAMD--EGQYDGKVDVWSLGITCIEL STE20_TAO_TAO3 ---------NSFVGTPYWMAPEVILAMD--EGQYDGKVDIWSLGITCIEL STE20_PAKA_PAK1 K-R------STMVGTPYWMAPEVVTRK-----AYGPKVDIWSLGIMAIEM STE20_PAKA_PAK3 K-R------STMVGTPYWMAPEVVTRK-----AYGPKVDIWSLGIMAIEM STE20_PAKA_PAK2 K-R------STMVGTPYWMAPEVVTRK-----AYGPKVDIWSLGIMAIEM STE20_PAKB_PAK4 R-R------KSLVGTPYWMAPELISRL-----PYGPEVDIWSLGIMVIEM STE20_PAKB_PAK5 K-R------KSLVGTPYWMAPEVISRL-----PYGTEVDIWSLGIMVIEM STE20_PAKB_PAK6 K-R------KSLVGTPYWMAPEVISRS-----LYATEVDIWSLGIMVIEM STE20_FRAY_OSR1 ITR--NKVRKTFVGTPCWMAPEVMEQ----VRGYDFKADIWSFGITAIEL STE20_FRAY_STLK3 VTR--NKVRKTFVGTPCWMAPEVMEQ----VRGYDFKADMWSFGITAIEL STE20_STLK_STLK5 RQRVVHDFPKYSVKVLPWLSPEVLQQN---LQGYDAKSDIYSVGITACEL STE20_STLK_STLK6 RHRAVYDFPQFSTSVQPWLSPELLRQD---LHGYNVKSDIYSVGITACEL STE-Unique__COT -----VYFPKDLRGTEIYMSPEVILCR-----GHSTKADIYSLGATLIHM STE-Unique__NIK G-KS-LLTGDYIPGTETHMAPEVVLGR-----SCDAKVDVWSSCCMMLHM STE7__MAP2K1 NS---------FVGTRSYMSPERLQG-----THYSVQSDIWSMGLSLVEM STE7__MAP2K2 NS---------FVGTRSYMAPERLQG-----THYSVQSDIWSMGLSLVEL STE7__MAP2K5 KT---------YVGTNAYMAPERISG-----EQYGIHSDVWSLGISFMEI STE7__MAP2K6 KTI--------DAGCKPYMAPERINP-ELNQKGYSVKSDIWSLGITMIEL STE7__MAP2K3 KTM--------DAGCKPYMAPERINP-ELNQKGYNVKSDVWSLGITMIEM STE7__MAP2K4 KTR--------DAGCRPYMAPERIDP-SASRQGYDVRSDVWSLGITLYEL STE7__MAP2K7 KTR--------SAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVEL STE-Unique__Domain2_GCN2 E--------DVFEQTRVRFSDNALPY------KTGKKGDVWRLGLLLLSL :: : * : : STE11__MAP3K2 LTEKPPW---AEFE------------------------------------ STE11__MAP3K3 LTEKPPW---AEYE------------------------------------ STE11__MAP3K8 ATGKPPL---ASMD------------------------------------ STE11__MAP3K1 ACAKPPWNAEKHSN------------------------------------ STE11__MAP3K5 ATGKPPFY--ELGE------------------------------------ STE11__MAP3K7 ATSKPPFH--ELGE------------------------------------ STE11__MAP3K6 ATGRPPFH--ELGS------------------------------------ STE11__MAP3K4 VTGKRPWH--EYEH------------------------------------ STE20_MST_MST1 AEGKPPYADIHPMR------------------------------------ STE20_MST_MST2 AEGKPPYADIHPMR------------------------------------ STE20_YSK_MST3 ARGEPPHSELHPMK------------------------------------ STE20_YSK_YSK1 AKGEPPNSDLHPMR------------------------------------ STE20_YSK_MST4 AKGEPPNSDMHPMR------------------------------------ STE20_KHS_KHS1 GELQPPMFDLHPMR------------------------------------ STE20_KHS_KHS2 AELQPPMFDLHPMR------------------------------------ STE20_KHS_GCK GELQPPLFHLHPMR------------------------------------ STE20_KHS_HPK1 AELQPPLFDVHPLR------------------------------------ STE20_SLK_SLK AEIEPPHHELNPMR------------------------------------ STE20_SLK_LOK AQIEPPHHELNPMR------------------------------------ STE20_MSN_ZC1/HGK AEGAPPLCDMHPMR------------------------------------ STE20_MSN_ZC3/MINK AEGAPPLCDMHPMR------------------------------------ STE20_MSN_ZC2/TNIK AEGAPPLCDMHPMR------------------------------------ STE20_MSN_ZC4/NRK AEGAPPLCNLQPLE------------------------------------ STE20_NinaC_MYO3B GDGDPPLFDMHPVK------------------------------------ STE20_NinaC_MYO3A GDGDPPLADLHPMR------------------------------------ STE20_TAO_TAO2 AERKPPLFNMNAMS------------------------------------ STE20_TAO_TAO1 AERKPPLFNMNAMS------------------------------------ STE20_TAO_TAO3 AERKPPLFNMNAMS------------------------------------ STE20_PAKA_PAK1 IEGEPPYLNENPLR------------------------------------ STE20_PAKA_PAK3 VEGEPPYLNENPLR------------------------------------ STE20_PAKA_PAK2 VEGEPPYLNENPLR------------------------------------ STE20_PAKB_PAK4 VDGEPPYFNEPPLK------------------------------------ STE20_PAKB_PAK5 IDGEPPYFNEPPLQ------------------------------------ STE20_PAKB_PAK6 VDGEPPYFSDSPVQ------------------------------------ STE20_FRAY_OSR1 ATGAAPYHKYPPMK------------------------------------ STE20_FRAY_STLK3 ATGAAPYHKYPPMK------------------------------------ STE20_STLK_STLK5 ANGHVPFKDMPATQ------------------------------------ STE20_STLK_STLK6 ASGQVPFQDMHRTQ------------------------------------ STE-Unique__COT QTGTPPWVKRYPRSA----------------------------------- STE-Unique__NIK LNGCHPWTQFFRG------------------------------------- STE7__MAP2K1 AVGRYPIPPPDAKELELMFG-CQVEGDAAETP---PRPRTPGRPLSSYGM STE7__MAP2K2 AVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRPPGRPVSGHGM STE7__MAP2K5 QKNQGSLMP----------------------------------------- STE7__MAP2K6 AILRFPYDSWG--------------------------------------- STE7__MAP2K3 AILRFPYESWG--------------------------------------- STE7__MAP2K4 ATGRFPYPKWN--------------------------------------- STE7__MAP2K7 ATGQFPYKNCK--------------------------------------- STE-Unique__Domain2_GCN2 SQGQECG------------------------------------------- STE11__MAP3K2 -------AMAAIFKIATQP-TNPKLP------------------------ STE11__MAP3K3 -------AMAAIFKIATQP-TNPQLP------------------------ STE11__MAP3K8 -------RMAAMFYIGAHRGLMPPLP------------------------ STE11__MAP3K1 -------HLALIFKIASAT-TAPSIP------------------------ STE11__MAP3K5 -------PQAAMFKVGMFK-VHPEIP------------------------ STE11__MAP3K7 -------PQAAMFKVGMFK-IHPEIP------------------------ STE11__MAP3K6 -------PQAAMFQVGMYK-VHPPMP------------------------ STE11__MAP3K4 -------NFQIMYKVGMG--HKPPIP------------------------ STE20_MST_MST1 ----------AIFMIPTN--PPPTFRK----------------------- STE20_MST_MST2 ----------AIFMIPTN--PPPTFRK----------------------- STE20_YSK_MST3 ----------VLFLIPKN--NPPTLEG----------------------- STE20_YSK_YSK1 ----------VLFLIPKN--SPPTLEG----------------------- STE20_YSK_MST4 ----------VLFLIPKN--NPPTLVG----------------------- STE20_KHS_KHS1 ----------ALFLMSKSNFQPPKLKD----------------------- STE20_KHS_KHS2 ----------ALFLMTKSNFQPPKLKD----------------------- STE20_KHS_GCK ----------ALMLMSKSSFQPPKLRD----------------------- STE20_KHS_HPK1 ----------VLFLMTKSGYQPPRLKE----------------------- STE20_SLK_SLK ----------VLLKIAKS--EPPTLAQ----------------------- STE20_SLK_LOK ----------VLLKIAKS--DPPTLLT----------------------- STE20_MSN_ZC1/HGK ----------ALFLIPRN--PPPRLK------------------------ STE20_MSN_ZC3/MINK ----------ALFLIPRN--PPPRLK------------------------ STE20_MSN_ZC2/TNIK ----------ALFLIPRN--PAPRLK------------------------ STE20_MSN_ZC4/NRK ----------ALFVILRE--SAPTVK------------------------ STE20_NinaC_MYO3B ----------TLFKIPRN--PPPTLLH----------------------- STE20_NinaC_MYO3A ----------ALFKIPRN--PPPKLRQ----------------------- STE20_TAO_TAO2 ----------ALYHIAQN--ESPVLQ------------------------ STE20_TAO_TAO1 ----------ALYHIAQN--ESPTLQ------------------------ STE20_TAO_TAO3 ----------ALYHIAQN--DSPTLQ------------------------ STE20_PAKA_PAK1 ----------ALYLIATN--GTPELQN----------------------- STE20_PAKA_PAK3 ----------ALYLIATN--GTPELQN----------------------- STE20_PAKA_PAK2 ----------ALYLIATN--GTPELQN----------------------- STE20_PAKB_PAK4 ----------AMKMIRDN--LPPRLKN----------------------- STE20_PAKB_PAK5 ----------AMRRIRDS--LPPRVKD----------------------- STE20_PAKB_PAK6 ----------AMKRLRDS--PPPKLKN----------------------- STE20_FRAY_OSR1 ----------VLMLTLQN--DPPS--------------------LETGVQ STE20_FRAY_STLK3 ----------VLMLTLQN--DPPT--------------------LETGVE STE20_STLK_STLK5 ----------MLLEKLNG--TVPCLLDTSTIPAEELTMSPSRSVANSGLS STE20_STLK_STLK6 ----------MLLQKLKG--PPYSPLDISIFPQSESRMKNSQSGVDSGIG STE-Unique__COT --------YPSYLYIIHK--QAPPLED----------------------- STE-Unique__NIK ----------PLCLKIAS--EPPPVRE----------------------- STE7__MAP2K1 DSRPPMAIFELLDYIVNE--PPPKLP------------------------ STE7__MAP2K2 DSRPAMAIFELLDYIVNE--PPPKLP------------------------ STE7__MAP2K5 --------LQLLQCIVDE--DSPVLP------------------------ STE7__MAP2K6 ------TPFQQLKQVVEE--PSPQLP------------------------ STE7__MAP2K3 ------TPFQQLKQVVEE--PSPQLP------------------------ STE7__MAP2K4 ------SVFDQLTQVVKG--DPPQLSNS---------------------- STE7__MAP2K7 ------TDFEVLTKVLQE--EPPLLPG----------------------- STE-Unique__Domain2_GCN2 -----------EYPVT-------IP------------------------- STE11__MAP3K2 ----------------------PHVSDYTRDFLKRIFVEAKL-RPSADEL STE11__MAP3K3 ----------------------SHISEHGRDFLRRIFVEARQ-RPSAEEL STE11__MAP3K8 ----------------------DHFSENAADFVRMCLTRDQHERPSALQL STE11__MAP3K1 ----------------------SHLSPGLRDVALRCLELQPQDRPPSREL STE11__MAP3K5 ----------------------ESMSAEAKAFILKCFEPDPDKRACANDL STE11__MAP3K7 ----------------------EALSAEARAFILSCFEPDPHKRATTAEL STE11__MAP3K6 ----------------------SSLSAEAQAFLLRTFEPDPRLRASAQTL STE11__MAP3K4 ----------------------ERLSPEGKDFLSHCLESDPKMRWTASQL STE20_MST_MST1 ---------------------PELWSDNFTDFVKQCLVKSPEQRATATQL STE20_MST_MST2 ---------------------PELWSDDFTDFVKKCLVKNPEQRATATQL STE20_YSK_MST3 -----------------------NYSKPLKEFVEACLNKEPSFRPTAKEL STE20_YSK_YSK1 -----------------------QHSKPFKEFVEACLNKDPRFRPTAKEL STE20_YSK_MST4 -----------------------DFTKSFKEFIDACLNKDPSFRPTAKEL STE20_KHS_KHS1 ---------------------KTKWSSTFHNFVKIALTKNPKKRPTAERL STE20_KHS_KHS2 ---------------------KMKWSNSFHHFVKMALTKNPKKRPTAEKL STE20_KHS_GCK ---------------------KTRWTQNFHHFLKLALTKNPKKRPTAEKL STE20_KHS_HPK1 ---------------------KGKWSAAFHNFIKVTLTKSPKKRPSATKM STE20_SLK_SLK ---------------------PSRWSSNFKDFLKKCLEKNVDARWTTSQL STE20_SLK_LOK ---------------------PSKWSVEFRDFLKIALDKNPETRPSAAQL STE20_MSN_ZC1/HGK ---------------------SKKWSKKFFSFIEGCLVKNYMQRPSTEQL STE20_MSN_ZC3/MINK ---------------------SKKWSKKFIDFIDTCLIKTYLSRPPTEQL STE20_MSN_ZC2/TNIK ---------------------SKKWSKKFQSFIESCLVKNHSQRPATEQL STE20_MSN_ZC4/NRK ---------------------SSGWSRKFHNFMEKCTIKNFLFRPTSANM STE20_NinaC_MYO3B ---------------------PEKWCEEFNHFISQCLIKDFERRPSVTHL STE20_NinaC_MYO3A ---------------------PELWSAEFNDFISKCLTKDYEKRPTVSEL STE20_TAO_TAO2 ---------------------SGHWSEYFRNFVDSCLQKIPQDRPTSEVL STE20_TAO_TAO1 ---------------------SNEWSDYFRNFVDSCLQKIPQDRPTSEEL STE20_TAO_TAO3 ---------------------SNEWTDSFRRFVDYCLQKIPQERPTSAEL STE20_PAKA_PAK1 ---------------------PEKLSAIFRDFLNRCLDMDVEKRGSAKEL STE20_PAKA_PAK3 ---------------------PERLSAVFRDFLNRCLEMDVDRRGSAKEL STE20_PAKA_PAK2 ---------------------PEKLSPIFRDFLNRCLEMDVEKRGSAKEL STE20_PAKB_PAK4 ---------------------LHKVSPSLKGFLDRLLVRDPAQRATAAEL STE20_PAKB_PAK5 ---------------------LHKVSSVLRGFLDLMLVREPSQRATAQEL STE20_PAKB_PAK6 ---------------------SHKVSPVLRDFLERMLVRDPQERATAQEL STE20_FRAY_OSR1 D-----------------KEMLKKYGKSFRKMISLCLQKDPEKRPTAAEL STE20_FRAY_STLK3 D-----------------KEMMKKYGKSFRKLLSLCLQKDPSKRPTAAEL STE20_STLK_STLK5 DSLTTST-PRPSNGDSPSHPYHRTFSPHFHHFVEQCLQRNPDARPSASTL STE20_STLK_STLK6 ESVLVSSGTHTVNSDRLHTPSSKTFSPAFFSLVQLCLQQDPEKRPSASSL STE-Unique__COT --------------------IADDCSPGMRELIEASLERNPNHRPRAADL STE-Unique__NIK --------------------IPPSCAPLTAQAIQEGLRKEPIHRVSAAEL STE7__MAP2K1 ---------------------SGVFSLEFQDFVNKCLIKNPAERADLKQL STE7__MAP2K2 ---------------------NGVFTPDFQEFVNKCLIKNPAERADLKML STE7__MAP2K5 ---------------------VGEFSEPFVHFITQCMRKQPKERPAPEEL STE7__MAP2K6 ---------------------ADKFSAEFVDFTSQCLKKNSKERPTYPEL STE7__MAP2K3 ---------------------ADRFSPEFVDFTAQCLRKNPAERMSYLEL STE7__MAP2K4 --------------------EEREFSPSFINFVNLCLTKDESKRPKYKEL STE7__MAP2K7 ---------------------HMGFSGDFQSFVKDCLTKDHRKRPKYNKL STE-Unique__Domain2_GCN2 ----------------------SDLPADFQDFLKKCVCLDDKERWSPQQL * : STE11__MAP3K2 LRHMFV------------- STE11__MAP3K3 LTHHFA------------- STE11__MAP3K8 LKHSFL------------- STE11__MAP3K1 LKHPVF------------- STE11__MAP3K5 LVDEFL------------- STE11__MAP3K7 LREGFL------------- STE11__MAP3K6 LGDPFL------------- STE11__MAP3K4 LDHSFV------------- STE20_MST_MST1 LQHPFV------------- STE20_MST_MST2 LQHPFI------------- STE20_YSK_MST3 LKHKFI------------- STE20_YSK_YSK1 LKHKFI------------- STE20_YSK_MST4 LKHKFI------------- STE20_KHS_KHS1 LTHTFV------------- STE20_KHS_KHS2 LQHPFV------------- STE20_KHS_GCK LQHPFT------------- STE20_KHS_HPK1 LSHQLV------------- STE20_SLK_SLK LQHPFV------------- STE20_SLK_LOK LEHPFV------------- STE20_MSN_ZC1/HGK LKHPFI------------- STE20_MSN_ZC3/MINK LKFPFI------------- STE20_MSN_ZC2/TNIK MKHPFI------------- STE20_MSN_ZC4/NRK LQHPFV------------- STE20_NinaC_MYO3B LDHPFI------------- STE20_NinaC_MYO3A LQHKFI------------- STE20_TAO_TAO2 LKHRFV------------- STE20_TAO_TAO1 LKHIFV------------- STE20_TAO_TAO3 LRHDFV------------- STE20_PAKA_PAK1 LQHQFL------------- STE20_PAKA_PAK3 LQHPFL------------- STE20_PAKA_PAK2 LQHPFL------------- STE20_PAKB_PAK4 LKHPFL------------- STE20_PAKB_PAK5 LGHPFL------------- STE20_PAKB_PAK6 LDHPFL------------- STE20_FRAY_OSR1 LRHKFF------------- STE20_FRAY_STLK3 LKCKFF------------- STE20_STLK_STLK5 LNHSFF------------- STE20_STLK_STLK6 LSHVFF------------- STE-Unique__COT LKHEAL------------- STE-Unique__NIK GGKVNRALQQVGGLKSPWR STE7__MAP2K1 MVHAFI------------- STE7__MAP2K2 TNHTFI------------- STE7__MAP2K5 MGHPFI------------- STE7__MAP2K6 MQHPFF------------- STE7__MAP2K3 MEHPFF------------- STE7__MAP2K4 LKHPFI------------- STE7__MAP2K7 LEHSFI------------- STE-Unique__Domain2_GCN2 LKHSFI-------------