CLUSTAL W (1.8) multiple sequence alignment Lmr__LMR1 LLYLKEIGRGWFGKVFLGEV------------N----SGIS----------SAQVVVKEL Lmr__LMR3 LSYLQEIGSGWFGKVILGEI------------F----SDYT----------PAQVVVKEL Lmr__LMR2 LNYIQEIGNGWFGKVLLGEI------------Y----TGTS----------VARVIVKEL CCK4__CCK4 LQPITTLGKSEFGEVFLAKA------------QGL-EEGVA----------ETLVLVKSL Ack__ACK LRLLEKLGDGSFGVVRRGEW------------DAP-SGKTV------------SVAVKCL Ack__TNK1 VCRGELLGSGCFGVVHRGLW------------TLP-SGKSV------------PVAVKSL EGFR__EGFR FKKIKVLGSGAFGTVYKGLW------------IPEGEKVKI------------PVAIKEL EGFR__HER2/ErbB2 LRKVKVLGSGAFGTVYKGIW------------IPDGENVKI------------PVAIKVL EGFR__HER4/ErbB4 LKRVKVLGSGAFGTVYKGIW------------VPEGETVKI------------PVAIKIL EGFR__HER3/ErbB3 LRKLKVLGSGVFGTVHKGVW------------IPEGESIKI------------PVCIKVI JakA__JAK1 LKRIRDLGEGHFGKVELCRY------------DPE-DNTGE------------QVAVKSL JakA__TYK2 LKKIRDLGEGHFGKVSLYCY------------DPTNDGTGE------------MVAVKAL JakA__JAK2 LKFLQQLGKGNFGSVEMCRY------------DPLQDNTGE------------VVAVKKL JakA__JAK3 LKYISQLGKGNFGSVELCRY------------DPLAHNTGA------------LVAVKQL Syk__SYK TLEDKELGSGNFGTVKKGYY------------QMK--KVVK------------TVAVKIL Syk__ZAP70 LIADIELGCGNFGSVRQGVY------------RMR--KKQI------------DVAIKVL Fak__FAK IELGRCIGEGQFGDVHQGIY------------MSP-ENPAL------------AVAIKTC Fak__PYK2 VVLNRILGEGLFGEVYEGVY------------TNH-KGEKI------------NVAVKTC Eph__EphA3 ISIDKVVGAGEFGEVCSGRL------------KLP-SKKEI------------SVAIKTL Eph__EphA5 ITIERVIGAGEFGEVCSGRL------------KLP-GKREL------------PVAIKTL Eph__EphA4 IKIEKVIGVGEFGEVCSGRL------------KVP-GKREI------------CVAIKTL Eph__EphA6 IRIERVIGAGEFGEVCSGRL------------KTP-GKREI------------PVAIKTL Eph__EphA7 IKIERVIGAGEFGEVCSGRL------------KLP-GKRDV------------AVAIKTL Eph__EphB1 VKIEEVIGAGEFGEVYKGRL------------KLP-GKREI------------YVAIKTL Eph__EphB2 VKIEQVIGAGEFGEVCSGHL------------KLP-GKREI------------FVAIKTL Eph__EphB3 VKIEEVIGAGEFGEVCRGRL------------KQP-GRREV------------FVAIKTL Eph__EphB4 VKIEEVIGAGEFGEVCRGRL------------KAP-GKKES------------CVAIKTL Eph__EphA8 IHIEKIIGSGDSGEVCYGRL------------RVP-GQRDV------------PVAIKAL Eph__EphA2 VTRQKVIGAGEFGEVYKGML------------KTSSGKKEV------------PVAIKTL Eph__EphA1 LMVDTVIGEGEFGEVYRGTL------------RLP-SQDCK------------TVAIKTL Eph__EphB6 IKIEEVIGTGSFGEVRQGRL------------QPR-GRREQ------------TVAIQAL Eph__EphA10 VTLERSLGGGRFGELCCGCL------------QLP-GRQEL------------LVAVHML DDR__DDR1 LRFKEKLGEGQFGEVHLCEV------------DSPQDLVSLDFPLNVRKGHPLLVAVKIL DDR__DDR2 LTFKEKLGEGQFGEVHLCEV------------EGMEKFKDKDFALDVSANQPVLVAVKML Trk__TRKB IVLKRELGEGAFGKVFLAEC------------YNLCPEQDK-----------ILVAVKTL Trk__TRKC IVLKRELGEGAFGKVFLAEC------------YNLSPTKDK-----------MLVAVKAL Trk__TRKA IVLKWELGEGAFGKVFLAEC------------HNLLPEQDK-----------MLVAVKAL Musk__MUSK IEYVRDIGEGAFGRVFQARA------------PGLLPYEPF-----------TMVAVKML Ror__ROR1 VRFMEELGECAFGKIYKGHL------------YLPG-MDHA-----------QLVAIKTL Ror__ROR2 VRFMEELGEDRFGKVYKGHL------------FGPAPGEQT-----------QAVAIKTL Abl__ABL ITMKHKLGGGQYGEVYEGVW------------KKY----------------SLTVAVKTL Abl__ARG ITMKHKLGGGQYGEVYVGVW------------KKY----------------SLTVAVKTL Src__HCK LKLEKKLGAGQFGEVWMATY------------NK-----------------HTKVAVKTM Src__LYN IKLVKRLGAGQFGEVWMGYY------------NN-----------------STKVAVKTL Src__LCK LKLVERLGAGQFGEVWMGYY------------NG-----------------HTKVAVKSL Src__BLK LRLVRKLGSGQFGEVWMGYY------------KN-----------------NMKVAIKTL Src__SRC LRLEVKLGQGCFGEVWMGTW------------NG-----------------TTRVAIKTL Src__YES LRLEVKLGQGCFGEVWMGTW------------NG-----------------TTKVAIKTL Src__FYN LQLIKRLGNGQFGEVWMGTW------------NG-----------------NTKVAIKTL Src__FGR ITLERRLGTGCFGDVWLGTW------------NG-----------------STKVAVKTL Src__FRK IQLLKRLGSGQFGEVWEGLW------------NN-----------------TTPVAVKTL Src__BRK FTLCRKLGSGYFGEVFEGLW------------KD-----------------RVQVAIKVI Src__SRM FALGRKLGEGYFGEVWEGLW------------LG-----------------SLPVAIKVI Tec__BTK LTFLKELGTGQFGVVKYGKW------------RG-----------------QYDVAIKMI Tec__BMX ITLLKELGSGQFGVVQLGKW------------KG-----------------QYDVAVKMI Tec__TEC LTFMRELGSGLFGVVRLGKW------------RA-----------------QYKVAIKAI Tec__TXK LAFIKEIGSGQFGVVHLGEW------------RS-----------------HIQVAIKAI Tec__ITK LTFVQEIGSGQFGLVHLGYW------------LN-----------------KDKVAIKTI Csk__CSK LKLLQTIGKGEFGDVMLGDY------------R------------------GNKVAVKCI Csk__CTK LTLGAQIGEGEFGAVLQGEY------------L------------------GQKVAVKNI Fer__FER VILGELLGKGNFGEVYKGTL------------K-D----------------KTSVAVKTC Fer__FES LVLGEQIGRGNFGEVFSGRL------------RAD----------------NTLVAVKSC FGFR__FGFR2 LTLGKPLGEGCFGQVVMAEA------------VGIDKDKPKE---------AVTVAVKML FGFR__FGFR3 LTLGKPLGEGCFGQVVMAEA------------IGIDKDRAAK---------PVTVAVKML FGFR__FGFR1 LVLGKPLGEGCFGQVVLAEA------------IGLDKDKPNR---------VTKVAVKML FGFR__FGFR4 LVLGKPLGEGCFGQVVRAEA------------FGMDPARPDQ---------ASTVAVKML Ret__RET LVLGKTLGEGEFGKVVKATA------------FHL-KGRAG----------YTTVAVKML VEGFR__KDR LKLGKPLGRGAFGQVIEADA------------FGIDKTAT-----------CRTVAVKML VEGFR__FLT1 LKLGKSLGRGAFGKVVQASA------------FGIKKSPT-----------CRTVAVKML VEGFR__FLT4 LHLGRVLGYGAFGKVVEASA------------FGIHKGSS-----------CDTVAVKML PDGFR__FMS LQFGKTLGAGAFGKVVEATA------------FGLGKEDA-----------VLKVAVKML PDGFR__KIT LSFGKTLGAGAFGKVVEATA------------YGLIKSDA-----------AMTVAVKML PDGFR__PDGFRa LVLGRVLGSGAFGKVVEGTA------------YGLSRSQP-----------VMKVAVKML PDGFR__PDGFRb LVLGRTLGSGAFGQVVEATA------------HGLSHSQA-----------TMKVAVKML PDGFR__FLT3 LEFGKVLGSGAFGKVMNATA------------YGISKTGV-----------SIQVAVKML Tie__TIE2 IKFQDVIGEGNFGQVLKAR---------------IKKDGL-----------RMDAAIKRM Tie__TIE1 ITFEDLIGEGNFGQVIRAM---------------IKKDGL-----------KMNAAIKML Axl__AXL VALGKTLGEGEFGAVMEGQL------------NQDD---S-----------ILKVAVKTM Axl__MER LILGKILGEGEFGSVMEGNL------------KQEDG--T-----------SLKVAVKTM Axl__TYRO3 FTLGRMLGKGEFGSVREAQL------------KQEDG--S-----------FVKVAVKML Met__MET VHFNEVIGRGHFGCVYHGTL------------LDNDG--K-----------KIHCAVKSL Met__RON THSDRVIGKGHFGVVYHGEY------------IDQAQ--N-----------RIQCAIKSL Ryk__RYK ITLKDVLQEGTFGRIFHGIL------------IDEKDPNK-----------EKQAFVKTV Alk__ALK ITLIRGLGHGAFGEVYEGQV------------SGMPNDPS-----------PLQVAVKTL Alk__LTK VTLLRALGHGAFGEVYEGLV------------IGLPGDSS-----------PLQVAIKTL Sev__ROS LTLRLLLGSGAFGEVYEGTA------------VDILGVGSG----------EIKVAVKTL InsR__INSR ITLLRELGQGSFGMVYEGNA------------RDIIKGEA-----------ETRVAVKTV InsR__IGF1R ITMSRELGQGSFGMVYEGVA------------KGVVKDEP-----------ETRVAIKTV InsR__IRR ISIIRELGQGSFGMVYEGLA------------RGLEAGEE-----------STPVALKTV JakB__Domain2_JAK1 LVQGEHLGRGTRTHIYSGTL------------MDYKD--DEGT----SEEKKIKVILKVL JakB__Domain2_TYK2 ITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGR----DRGQELRVVLKVL JakB__Domain2_JAK2 LIFNESLGQGTFTKIFKGVR------------REVGDY---------GQLHETEVLLKVL JakB__Domain2_JAK3 LEWHENLGHGSFTKIYRGCR------------HEVVD----------GEARKTEVLLKVM TK-Unique__SuRTK106 SEVLEQICSGSCGPIFRANMN-----------TGDPSKPK-------------SVILKAL : : :: Lmr__LMR1 QA-SASV---QEQMQFLE-EVQPYRALK-HSNLLQCLAQCAEV----------------- Lmr__LMR3 RA-SAGP---LEQRKFIS-EAQPYRSLQ-HPNVLQCLGLCVET----------------- Lmr__LMR2 KA-SANP---KEQDTFLK-NGEPYYILQ-HPNILQCVGQCVEA----------------- CCK4__CCK4 QS-KDE----QQQLDFRR-ELEMFGKLN-HANVVRLLGLCREA----------------- Ack__ACK KP-DVLS-QPEAMDDFIR-EVNAMHSLD-HRNLIRLYGVVLTP----------------- Ack__TNK1 RV-GPEGPMGTELGDFLR-EVSVMMNLE-HPHVLRLHGLVLGQ----------------- EGFR__EGFR RE-ATSP---KANKEILD-EAYVMASVD-NPHVCRLLGICLTS----------------- EGFR__HER2/ErbB2 RE-NTSP---KANKEILD-EAYVMAGVG-SPYVSRLLGICLTS----------------- EGFR__HER4/ErbB4 NE-TTGP---KANVEFMD-EALIMASMD-HPHLVRLLGVCLSP----------------- EGFR__HER3/ErbB3 ED-KSGR---QSFQAVTD-HMLAIGSLD-HAHIVRLLGLCPGS----------------- JakA__JAK1 KP-ESGG---NHIADLKK-EIEILRNLY-HENIVKYKGICTEDG---------------- JakA__TYK2 KA-DCGP---QHRSGWKQ-EIDILRTLY-HEHIIKYKGCCEDQG---------------- JakA__JAK2 Q--HSTE---EHLRDFER-EIEILKSLQ-HDNIVKYKGVCYSAG---------------- JakA__JAK3 Q--HSGP---DQQRDFQR-EIQILKALH-SDFIVKYRGVSYGPG---------------- Syk__SYK KN-EANDP--ALKDELLA-EANVMQQLD-NPYIVRMIGICEAE----------------- Syk__ZAP70 K--QGTEK--ADTEEMMR-EAQIMHQLD-NPYIVRLIGVCQAE----------------- Fak__FAK KN--CTSDS--VREKFLQ-EALTMRQFD-HPHIVKLIGVITEN----------------- Fak__PYK2 KK-DCTLD---NKEKFMS-EAVIMKNLD-HPHIVKLIGIIEEE----------------- Eph__EphA3 KV-GYTE---KQRRDFLG-EASIMGQFD-HPNIIRLEGVVTK------------------ Eph__EphA5 KV-GYTE---KQRRDFLG-EASIMGQFD-HPNIIHLEGVVTK------------------ Eph__EphA4 KA-GYTD---KQRRDFLS-EASIMGQFD-HPNIIHLEGVVTK------------------ Eph__EphA6 KG-GHMD---RQRRDFLR-EASIMGQFD-HPNIIRLEGVVTKRSFPAIGVEAFCPSFLRA Eph__EphA7 KV-GYTE---KQRRDFLC-EASIMGQFD-HPNVVHLEGVVTR------------------ Eph__EphB1 KA-GYSE---KQRRDFLS-EASIMGQFD-HPNIIRLEGVVTK------------------ Eph__EphB2 KS-GYTE---KQRRDFLS-EASIMGQFD-HPNVIHLEGVVTK------------------ Eph__EphB3 KV-GYTE---RQRRDFLS-EASIMGQFD-HPNIIRLEGVVTK------------------ Eph__EphB4 KG-GYTE---RQRREFLS-EASIMGQFE-HPNIIRLEGVVTN------------------ Eph__EphA8 KA-GYTE---RQRRDFLS-EASIMGQFD-HPNIIRLEGVVTR------------------ Eph__EphA2 KA-GYTE---KQRVDFLG-EAGIMGQFS-HHNIIRLEGVISK------------------ Eph__EphA1 KD-TSPG---GQWWNFLR-EATIMGQFS-HPHILHLEGVVTK------------------ Eph__EphB6 WA-GGAE---SLQMTFLG-RAAVLGQFQ-HPNILRLEGVVTK------------------ Eph__EphA10 RD-SASD---SQRLGFLA-EALTLGQFD-HSHIVRLEGVVTR------------------ DDR__DDR1 RP-DATK---NARNDFLK-EVKIMSRLK-DPNIIRLLGVCVQD----------------- DDR__DDR2 RA-DANK---NARNDFLK-EIKIMSRLK-DPNIIHLLSVCITD----------------- Trk__TRKB K--DASD---NARKDFHR-EAELLTNLQ-HEHIVKFYGVCVEG----------------- Trk__TRKC K--DPTL---AARKDFQR-EAELLTNLQ-HEHIVKFYGVCGDG----------------- Trk__TRKA K--EASE---SARQDFQR-EAELLTMLQ-HQHIVRFFGVCTEG----------------- Musk__MUSK KE-EASA---DMQADFQR-EAALMAEFD-NPNIVKLLGVCAVG----------------- Ror__ROR1 KD-YNNP---QQWMEFQQ-EASLMAELH-HPNIVCLLGAVTQE----------------- Ror__ROR2 KD-KAEG---PLREEFRH-EAMLRARLQ-HPNVVCLLGVVTKD----------------- Abl__ABL KE-DTME-----VEEFLK-EAAVMKEIK-HPNLVQLLGVCTRE-P--------------- Abl__ARG KE-DTME-----VEEFLK-EAAVMKEIK-HPNLVQLLGVCTLE-P--------------- Src__HCK KP-GSMS-----VEAFLA-EANVMKTLQ-HDKLVKLHAVVTK--E--------------- Src__LYN KP-GTMS-----VQAFLE-EANLMKTLQ-HDKLVRLYAVVTRE-E--------------- Src__LCK KQ-GSMS-----PDAFLA-EANLMKQLQ-HQRLVRLYAVVTQ--E--------------- Src__BLK KE-GTMS-----PEAFLG-EANVMKALQ-HERLVRLYAVVTK--E--------------- Src__SRC KP-GTMS-----PEAFLQ-EAQVMKKLR-HEKLVQLYAVVSE--E--------------- Src__YES KP-GTMM-----PEAFLQ-EAQIMKKLR-HDKLVPLYAVVSE--E--------------- Src__FYN KP-GTMS-----PESFLE-EAQIMKKLK-HDKLVQLYAVVSE--E--------------- Src__FGR KP-GTMS-----PKAFLE-EAQVMKLLR-HDKLVQLYAVVSE--E--------------- Src__FRK KP-GSMD-----PNDFLR-EAQIMKNLR-HPKLIQLYAVCTLE-D--------------- Src__BRK SR-DNLL-----HQQMLQSEIQAMKKLR-HKHILALYAVVSVG-D--------------- Src__SRM KS-ANMK-----LTDLAK-EIQTLKGLR-HERLIRLHAVCSGG-E--------------- Tec__BTK KE-GSMS-----EDEFIE-EAKVMMNLS-HEKLVQLYGVCTKQ-R--------------- Tec__BMX KE-GSMS-----EDEFFQ-EAQTMMKLS-HPKLVKFYGVCSKE-Y--------------- Tec__TEC RE-GAMC-----EEDFIE-EAKVMMKLT-HPKLVQLYGVCTQQ-K--------------- Tec__TXK NE-GSMS-----EEDFIE-EAKVMMKLS-HSKLVQLYGVCIQR-K--------------- Tec__ITK RE-GAMS-----EEDFIE-EAEVMMKLS-HPKLVQLYGVCLEQ-A--------------- Csk__CSK KN-DAT------AQAFLA-EASVMTQLR-HSNLVQLLGVIVEEKG--------------- Csk__CTK KC-DVT------AQAFLD-ETAVMTKMQ-HENLVRLLGVILHQ----------------- Fer__FER KE-DLPQ---ELKIKFLQ-EAKILKQYD-HPNIVKLIGVCTQRQ---------------- Fer__FES RE-TLPP---DLKAKFLQ-EARILKQYS-HPNIVRLIGVCTQKQ---------------- FGFR__FGFR2 KD-DATE---KDLSDLVS-EMEMMKMIGKHKNIINLLGACTQ-DG--------------- FGFR__FGFR3 KD-DATD---KDLSDLVS-EMEMMKMIGKHKNIINLLGACTQ-GG--------------- FGFR__FGFR1 KS-DATE---KDLSDLIS-EMEMMKMIGKHKNIINLLGACTQ-DG--------------- FGFR__FGFR4 KD-NASD---KDLADLVS-EMEVMKLIGRHKNIINLLGVCTQ-EG--------------- Ret__RET KE-NASP---SELRDLLS-EFNVLKQVN-HPHVIKLYGACSQ-DG--------------- VEGFR__KDR KE-GATH---SEHRALMS-ELKILIHIGHHLNVVNLLGACTKPGG--------------- VEGFR__FLT1 KE-GATA---SEYKALMT-ELKILTHIGHHLNVVNLLGACTKQGG--------------- VEGFR__FLT4 KE-GATA---SEHRALMS-ELKILIHIGNHLNVVNLLGACTKPQG--------------- PDGFR__FMS KS-TAHA---DEKEALMS-ELKIMSHLGQHENIVNLLGACTH-GG--------------- PDGFR__KIT KP-SAHL---TEREALMS-ELKVLSYLGNHMNIVNLLGACTI-GG--------------- PDGFR__PDGFRa KP-TARS---SEKQALMS-ELKIMTHLGPHLNIVNLLGACTK-SG--------------- PDGFR__PDGFRb KS-TARS---SEKQALMS-ELKIMSHLGPHLNVVNLLGACTK-GG--------------- PDGFR__FLT3 KE-KADS---SEREALMS-ELKMMTQLGSHENIVNLLGACTL-SG--------------- Tie__TIE2 KE-YASK---DDHRDFAG-ELEVLCKLGHHPNIINLLGACEH-RG--------------- Tie__TIE1 KE-YASE---NDHRDFAG-ELEVLCKLGHHPNIINLLGACKN-RG--------------- Axl__AXL KIAICTR---SELEDFLS-EAVCMKEFD-HPNVMRLIGVCFQGSER-------------- Axl__MER KLDNSSH---REIEEFLS-EAACMKDFS-HPNVIRLLGVCIEMSS--------------- Axl__TYRO3 KADIIAS---SDIEEFLR-EAACMKEFD-HPHVAKLVGVSLRSRAK-------------- Met__MET NR-ITDI---GEVSQFLT-EGIIMKDFS-HPNVLSLLGICLRSEG--------------- Met__RON SR-ITEM---QQVEAFLR-EGLLMRGLN-HPNVLALIGIMLPPEG--------------- Ryk__RYK KD-QASE---IQVTMMLT-ESCKLRGLH-HRNLLPITHVCIEEGE--------------- Alk__ALK PE-VCSE---QDELDFLM-EALIISKFN-HQNIVRCIGVSLQSLP--------------- Alk__LTK PE-LCSP---QDELDFLM-EALIISKFR-HQNIVRCVGLSLRATP--------------- Sev__ROS KK-GSTD---QEKIEFLK-EAHLMSKFN-HPNILKQLGVCLLNEP--------------- InsR__INSR NE-SASL---RERIEFLN-EASVMKGFT-CHHVVRLLGVVSKGQP--------------- InsR__IGF1R NE-AASM---RERIEFLN-EASVMKEFN-CHHVVRLLGVVSQGQP--------------- InsR__IRR NE-LASP---RECIEFLK-EASVMKAFK-CHHVVRLLGVVSQGQP--------------- JakB__Domain2_JAK1 DPSHRD-----ISLAFFE-AASMMRQVS-HKHIVYLYGVCVRD----------------- JakB__Domain2_TYK2 DPSHHD-----IALAFYE-TASLMSQVS-HTHLAFVHGVCVRG----------------- JakB__Domain2_JAK2 DKAHRN-----YSESFFE-AASMMSKLS-HKHLVLNYGVCVCG----------------- JakB__Domain2_JAK3 DAKHKN-----CMESFLE-AASLMSQVS-YRHLVLLHGVCMAG----------------- TK-Unique__SuRTK106 KEPAGLH----EVQDFLG-RIQFHQYLGKHKNLVQLEGCCTEK----------------- : Lmr__LMR1 -------------------------TPYLLVMEFCPLGDLKGYLRSCRVA---------- Lmr__LMR3 -------------------------LPFLLIMEFCQLGDLKRYLRAQRPP---------- Lmr__LMR2 -------------------------IPYLLVFEFCDLGDLKAYLRSEQ------------ CCK4__CCK4 -------------------------EPHYMVLEYVDLGDLKQFLRISKSKD--------- Ack__ACK --------------------------PMKMVTELAPLGSLLDRLRKHQG----------- Ack__TNK1 --------------------------PLQMVMELAPLGSLHARLTAPAPT---------- EGFR__EGFR --------------------------TVQLITQLMPFGCLLDYVREHKD----------- EGFR__HER2/ErbB2 --------------------------TVQLVTQLMPYGCLLDHVRENRG----------- EGFR__HER4/ErbB4 --------------------------TIQLVTQLMPHGCLLEYVHEHKD----------- EGFR__HER3/ErbB3 --------------------------SLQLVTQYLPLGSLLDHVRQHRG----------- JakA__JAK1 ------------------------GNGIKLIMEFLPSGSLKEYLPKNKN----------- JakA__TYK2 ------------------------EKSLQLVMEYVPLGSLRDYLPR--H----------- JakA__JAK2 ------------------------RRNLKLIMEYLPYGSLRDYLQKHKE----------- JakA__JAK3 ------------------------RPELRLVMEYLPSGCLRDFLQRHRA----------- Syk__SYK --------------------------SWMLVMEMAELGPLNKYLQQNR------------ Syk__ZAP70 --------------------------ALMLVMEMAGGGPLHKFLVGKRE----------- Fak__FAK --------------------------PVWIIMELCTLGELRSFLQVRKY----------- Fak__PYK2 --------------------------PTWIIMELYPYGELGHYLERNKN----------- Eph__EphA3 ------------------------SKPVMIVTEYMENGSLDSFLRKHDA----------- Eph__EphA5 ------------------------SKPVMIVTEYMENGSLDTFLKKNDG----------- Eph__EphA4 ------------------------CKPVMIITEYMENGSLDAFLRKNDG----------- Eph__EphA6 GFLNSIQAPHPVPGGGSLPPRIPAGRPVMIVVEYMENGSLDSFLRKHDG----------- Eph__EphA7 ------------------------GKPVMIVIEFMENGALDAFLRKHDG----------- Eph__EphB1 ------------------------SRPVMIITEFMENGALDSFLRQNDG----------- Eph__EphB2 ------------------------STPVMIITEFMENGSLDSFLRQNDG----------- Eph__EphB3 ------------------------SRPVMILTEFMENCALDSFLRLNDG----------- Eph__EphB4 ------------------------SMPVMILTEFMENGALDSFLRLNDG----------- Eph__EphA8 ------------------------GRLAMIVTEYMENGSLDTFLRTHDG----------- Eph__EphA2 ------------------------YKPMMIITEYMENGALDKFLREKDG----------- Eph__EphA1 ------------------------RKPIMIITEFMENAALDAFLRERED----------- Eph__EphB6 ------------------------SRPLMVLTEFMELGPLDSFLRQREG----------- Eph__EphA10 ------------------------GSTLMIVTEYMSHGALDGFLRRHEG----------- DDR__DDR1 -------------------------DPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGD DDR__DDR2 -------------------------DPLCMITEYMENGDLNQFLSRH--E--PPNSSSSD Trk__TRKB -------------------------DPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNP- Trk__TRKC -------------------------DPLIMVFEYMKHGDLNKFLRAHGPNAMILVDGQPR Trk__TRKA -------------------------RPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGED- Musk__MUSK -------------------------KPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDL Ror__ROR1 -------------------------QPVCMLFEYINQGDLHEFLIMRSPHSDVGCSSDED Ror__ROR2 -------------------------QPLSMIFSYCSHGDLHEFLVMRSPHSDVG-STDDD Abl__ABL --------------------------PFYIITEFMTYGNLLDYLRECNRQE--------- Abl__ARG --------------------------PFYIVTEYMPYGNLLDYLRECNREE--------- Src__HCK --------------------------PIYIITEFMAKGSLLDFLKSDEGSK--------- Src__LYN --------------------------PIYIITEYMAKGSLLDFLKSDEGGK--------- Src__LCK --------------------------PIYIITEYMENGSLVDFLKTPSGIK--------- Src__BLK --------------------------PIYIVTEYMARGCLLDFLKTDEGSR--------- Src__SRC --------------------------PIYIVTEYMSKGSLLDFLKGETGKY--------- Src__YES --------------------------PIYIVTEFMSKGSLLDFLKEGDGKY--------- Src__FYN --------------------------PIYIVTEYMNKGSLLDFLKDGEGRA--------- Src__FGR --------------------------PIYIVTEFMCHGSLLDFLKNPEGQD--------- Src__FRK --------------------------PIYIITELMRHGSLQEYLQNDTGSK--------- Src__BRK --------------------------PVYIITELMAKGSLLELLRDSDEKV--------- Src__SRM --------------------------PVYIVTELMRKGNLQAFLGTPEGRA--------- Tec__BTK --------------------------PIFIITEYMANGCLLNYLREMRHR---------- Tec__BMX --------------------------PIYIVTEYISNGCLLNYLRSHGKG---------- Tec__TEC --------------------------PIYIVTEFMERGCLLNFLRQRQGH---------- Tec__TXK --------------------------PLYIVTEFMENGCLLNYLRENKGK---------- Tec__ITK --------------------------PICLVFEFMEHGCLSDYLRTQRGL---------- Csk__CSK --------------------------GLYIVTEYMAKGSLVDYLRSRGR----------- Csk__CTK --------------------------GLYIVMEHVSKGNLVNFLRTRGR----------- Fer__FER --------------------------PVYIIMELVSGGDFLTFLRRKK------------ Fer__FES --------------------------PIYIVMELVQGGDFLTFLRTEG------------ FGFR__FGFR2 --------------------------PLYVIVEYASKGNLREYLRARR------------ FGFR__FGFR3 --------------------------PLYVLVEYAAKGNLREFLRARR------------ FGFR__FGFR1 --------------------------PLYVIVEYASKGNLREYLQARR------------ FGFR__FGFR4 --------------------------PLYVIVECAAKGNLREFLRARR------------ Ret__RET --------------------------PLLLIVEYAKYGSLRGFLRESR------------ VEGFR__KDR --------------------------PLMVIVEFCKFGNLSTYLRSKRNEFVPYK----- VEGFR__FLT1 --------------------------PLMVIVEYCKYGNLSNYLKSKRDLFFLNK----- VEGFR__FLT4 --------------------------PLMVIVEFCKYGNLSNFLRAKRDAFSPCA----- PDGFR__FMS --------------------------PVLVITEYCCYGDLLNFLRRKAEAMLGPSLSP-- PDGFR__KIT --------------------------PTLVITEYCCYGDLLNFLRRKRDSFICSKQ---- PDGFR__PDGFRa --------------------------PIYIITEYCFYGDLVNYLHKNRDSFLSHHPEK-- PDGFR__PDGFRb --------------------------PIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRR PDGFR__FLT3 --------------------------PIYLIFEYCCYGDLLNYLRSKREKFHRTWT---- Tie__TIE2 --------------------------YLYLAIEYAPHGNLLDFLRKSR------------ Tie__TIE1 --------------------------YLYIAIEYAPYGNLLDFLRKSR------------ Axl__AXL ----------------------ESFPAPVVILPFMKHGDLHSFLLYSRLGD--------- Axl__MER ----------------------QGIPKPMVILPFMKYGDLHTYLLYSRLET--------- Axl__TYRO3 ----------------------GRLPIPMVILPFMKHGDLHAFLLASRIGE--------- Met__MET --------------------------SPLVVLPYMKHGDLRNFIRNE------------- Met__RON --------------------------LPHVLLPYMCHGDLLQFIRSP------------- Ryk__RYK --------------------------KPMVILPYMNWGNLKLFLRQCKLVE--------- Alk__ALK --------------------------R-FILLELMAGGDLKSFLRETRPRP--------- Alk__LTK --------------------------R-LILLELMSGGDMKSFLRHSRPHL--------- Sev__ROS --------------------------Q-YIILELMEGGDLLTYLRKARMAT--------- InsR__INSR --------------------------T-LVVMELMAHGDLKSYLRSLRPEA--------- InsR__IGF1R --------------------------T-LVIMELMTRGDLKSYLRSLRPEM--------- InsR__IRR --------------------------T-LVIMELMTRGDLKSHLRSLRPEA--------- JakB__Domain2_JAK1 -------------------------VENIMVEEFVEGGPLDLFMHRKSD----------- JakB__Domain2_TYK2 -------------------------PENSMVTEYVEHGPLDVWLRRERG----------- JakB__Domain2_JAK2 -------------------------DENILVQEFVKFGSLDTYLKKNKN----------- JakB__Domain2_JAK3 -------------------------DS-TMVQEFVHLGAIDMYLRKRGH----------- TK-Unique__SuRTK106 -------------------------LPLYMVLEDVAQGDLLGFLWTCRRDVMTMDG---- : : : Lmr__LMR1 ------------------------------------------------------------ Lmr__LMR3 ------------------------------------------------------------ Lmr__LMR2 ------------------------------------------------------------ CCK4__CCK4 ------------------------------------------------------------ Ack__ACK ------------------------------------------------------------ Ack__TNK1 ----P------------------------------------------------------- EGFR__EGFR ------------------------------------------------------------ EGFR__HER2/ErbB2 ------------------------------------------------------------ EGFR__HER4/ErbB4 ------------------------------------------------------------ EGFR__HER3/ErbB3 ------------------------------------------------------------ JakA__JAK1 ------------------------------------------------------------ JakA__TYK2 ------------------------------------------------------------ JakA__JAK2 ------------------------------------------------------------ JakA__JAK3 ------------------------------------------------------------ Syk__SYK ------------------------------------------------------------ Syk__ZAP70 ------------------------------------------------------------ Fak__FAK ------------------------------------------------------------ Fak__PYK2 ------------------------------------------------------------ Eph__EphA3 ------------------------------------------------------------ Eph__EphA5 ------------------------------------------------------------ Eph__EphA4 ------------------------------------------------------------ Eph__EphA6 ------------------------------------------------------------ Eph__EphA7 ------------------------------------------------------------ Eph__EphB1 ------------------------------------------------------------ Eph__EphB2 ------------------------------------------------------------ Eph__EphB3 ------------------------------------------------------------ Eph__EphB4 ------------------------------------------------------------ Eph__EphA8 ------------------------------------------------------------ Eph__EphA2 ------------------------------------------------------------ Eph__EphA1 ------------------------------------------------------------ Eph__EphB6 ------------------------------------------------------------ Eph__EphA10 ------------------------------------------------------------ DDR__DDR1 G----------------------------------------------------------- DDR__DDR2 ------------------------------------------------------------ Trk__TRKB ------------------------------------------------------------ Trk__TRKC ------------------------------------------------------------ Trk__TRKA ------------------------------------------------------------ Musk__MUSK SMRAQV------------------------------------------------------ Ror__ROR1 G----------------------------------------------------------- Ror__ROR2 R----------------------------------------------------------- Abl__ABL ------------------------------------------------------------ Abl__ARG ------------------------------------------------------------ Src__HCK ------------------------------------------------------------ Src__LYN ------------------------------------------------------------ Src__LCK ------------------------------------------------------------ Src__BLK ------------------------------------------------------------ Src__SRC ------------------------------------------------------------ Src__YES ------------------------------------------------------------ Src__FYN ------------------------------------------------------------ Src__FGR ------------------------------------------------------------ Src__FRK ------------------------------------------------------------ Src__BRK ------------------------------------------------------------ Src__SRM ------------------------------------------------------------ Tec__BTK ------------------------------------------------------------ Tec__BMX ------------------------------------------------------------ Tec__TEC ------------------------------------------------------------ Tec__TXK ------------------------------------------------------------ Tec__ITK ------------------------------------------------------------ Csk__CSK ------------------------------------------------------------ Csk__CTK ------------------------------------------------------------ Fer__FER ------------------------------------------------------------ Fer__FES ------------------------------------------------------------ FGFR__FGFR2 ------------PPGM-------------------------------------------- FGFR__FGFR3 ------------PPGL-------------------------------------------- FGFR__FGFR1 ------------PPGL-------------------------------------------- FGFR__FGFR4 ------------PPGP-------------------------------------------- Ret__RET ------------KVGPG-------------------------------------YLGSGG VEGFR__KDR ------------TKGARFRQGKDYVG-A--------IPVDLKRRLDSITSSQSSASSGFV VEGFR__FLT1 ------------DAALHMEPKKEKMEPG--------LEQGKKPRLDSVTSSESFASSGFQ VEGFR__FLT4 ------------EKSP---EQRGRFRAM--------VELARLDRRRPGSSDRVLFARFSK PDGFR__FMS ---------GQDPEGGVDYKNIHLEKKY-------VRRDSG-----FSSQGVDTYVEMRP PDGFR__KIT ----------EDHAEAALYKNLLHSKES-------SCSDSTNEY-MDMKPGVSYVVPTKA PDGFR__PDGFRa -PKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQR PDGFR__PDGFRb PPSAELYSNAL-PVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIES PDGFR__FLT3 ------------EIFKEHNFSFYPTFQS--------HPNSS----MPGSREVQIHPDSDQ Tie__TIE2 ------------VLET-------------------------------------------- Tie__TIE1 ------------VLET-------------------------------------------- Axl__AXL ------------------------------------------------------------ Axl__MER ------------------------------------------------------------ Axl__TYRO3 ------------------------------------------------------------ Met__MET ------------------------------------------------------------ Met__RON ------------------------------------------------------------ Ryk__RYK ------------------------------------------------------------ Alk__ALK ------------------------------------------------------------ Alk__LTK ------------------------------------------------------------ Sev__ROS ------------------------------------------------------------ InsR__INSR ------------------------------------------------------------ InsR__IGF1R ------------------------------------------------------------ InsR__IRR ------------------------------------------------------------ JakB__Domain2_JAK1 ------------------------------------------------------------ JakB__Domain2_TYK2 ------------------------------------------------------------ JakB__Domain2_JAK2 ------------------------------------------------------------ JakB__Domain2_JAK3 ------------------------------------------------------------ TK-Unique__SuRTK106 ------------------------------------------------------------ Lmr__LMR1 ------------ESMAPDP---------------RTLQRMACEVACGVLHLHRNNFVHSD Lmr__LMR3 ------------EGLSPELP----------PRDLRTLQRMGLEIARGLAHLHSHNYVHSD Lmr__LMR2 ------------EHMRGDS-------------QTMLLQRMACEVAAGLAAMHKLHFLHSD CCK4__CCK4 ------------EKLKSQP------------LSTKQKVALCTQVALGMEHLSNNRFVHKD Ack__ACK ------------------------------HFLLGTLSRYAVQVAEGMGYLESKRFIHRD Ack__TNK1 ------------------------------PLLVALLCLFLRQLAGAMAYLGARGLVHRD EGFR__EGFR ------------------------------NIGSQYLLNWCVQIAKGMNYLEDRRLVHRD EGFR__HER2/ErbB2 ------------------------------RLGSQDLLNWCMQIAKGMSYLEDVRLVHRD EGFR__HER4/ErbB4 ------------------------------NIGSQLLLNWCVQIAKGMMYLEERRLVHRD EGFR__HER3/ErbB3 ------------------------------ALGPQLLLNWGVQIAKGMYYLEEHGMVHRN JakA__JAK1 ------------------------------KINLKQQLKYAVQICKGMDYLGSRQYVHRD JakA__TYK2 ------------------------------SIGLAQLLLFAQQICEGMAYLHAHDYIHRD JakA__JAK2 ------------------------------RIDHIKLLQYTSQICKGMEYLGTKRYIHRD JakA__JAK3 ------------------------------RLDASRLLLYSSQICKGMEYLGSRRCVHRD Syk__SYK ------------------------------HVKDKNIIELVHQVSMGMKYLEESNFVHRD Syk__ZAP70 ------------------------------EIPVSNVAELLHQVSMGMKYLEEKNFVHRD Fak__FAK ------------------------------SLDLASLILYAYQLSTALAYLESKRFVHRD Fak__PYK2 ------------------------------SLKVLTLVLYSLQICKAMAYLESINCVHRD Eph__EphA3 ------------------------------QFTVIQLVGMLRGIASGMKYLSDMGYVHRD Eph__EphA5 ------------------------------QFTVIQLVGMLRGISAGMKYLSDMGYVHRD Eph__EphA4 ------------------------------RFTVIQLVGMLRGIGSGMKYLSDMSYVHRD Eph__EphA6 ------------------------------HFTVIQLVGMLRGIASGMKYLSDMGYVHRD Eph__EphA7 ------------------------------QFTVIQLVGMLRGIAAGMRYLADMGYVHRD Eph__EphB1 ------------------------------QFTVIQLVGMLRGIAAGMKYLAEMNYVHRD Eph__EphB2 ------------------------------QFTVIQLVGMLRGIAAGMKYLADMNYVHRD Eph__EphB3 ------------------------------QFTVIQLVGMLRGIAAGMKYLSEMNYVHRD Eph__EphB4 ------------------------------QFTVIQLVGMLRGIASGMRYLAEMSYVHRD Eph__EphA8 ------------------------------QFTIMQLVGMLRGVGAGMRYLSDLGYVHRD Eph__EphA2 ------------------------------EFSVLQLVGMLRGIAAGMKYLANMNYVHRD Eph__EphA1 ------------------------------QLVPGQLVAMLQGIASGMNYLSNHNYVHRD Eph__EphB6 ------------------------------QFSSLQLVAMQRGVAAAMQYLSSFAFVHRS Eph__EphA10 ------------------------------QLVAGQLMGLLPGLASAMKYLSEMGYVHRG DDR__DDR1 -------------QAAQGP-----------TISYPMLLHVAAQIASGMRYLATLNFVHRD DDR__DDR2 -----------------VR-----------TVSYTNLKFMATQIASGMKYLSSLNFVHRD Trk__TRKB -----------------PT-----------ELTQSQMLHIAQQIAAGMVYLASQHFVHRD Trk__TRKC ---------------QAKG-----------ELGLSQMLHIASQIASGMVYLASQHFVHRD Trk__TRKA ---------------VAPG-----------PLGLGQLLAVASQVAAGMVYLAGLHFVHRD Musk__MUSK -------------SSPGPP-----------PLSCAEQLCIARQVAAGMAYLSERKFVHRD Ror__ROR1 ---------------TVKS-----------SLDHGDFLHIAIQIAAGMEYLSSHFFVHKD Ror__ROR2 ---------------TVKS-----------ALEPPDFVHLVAQIAAGMEYLSSHHVVHKD Abl__ABL -------------------------------VNAVVLLYMATQISSAMEYLEKKNFIHRD Abl__ARG -------------------------------VTAVVLLYMATQISSAMEYLEKKNFIHRD Src__HCK -------------------------------QPLPKLIDFSAQIAEGMAFIEQRNYIHRD Src__LYN -------------------------------VLLPKLIDFSAQIAEGMAYIERKNYIHRD Src__LCK -------------------------------LTINKLLDMAAQIAEGMAFIEERNYIHRD Src__BLK -------------------------------LSLPRLIDMSAQIAEGMAYIERMNSIHRD Src__SRC -------------------------------LRLPQLVDMAAQIASGMAYVERMNYVHRD Src__YES -------------------------------LKLPQLVDMAAQIADGMAYIERMNYIHRD Src__FYN -------------------------------LKLPNLVDMAAQVAAGMAYIERMNYIHRD Src__FGR -------------------------------LRLPQLVDMAAQVAEGMAYMERMNYIHRD Src__FRK -------------------------------IHLTQQVDMAAQVASGMAYLESRNYIHRD Src__BRK -------------------------------LPVSELLDIAWQVAEGMCYLESQNYIHRD Src__SRM -------------------------------LRLPPLLGFACQVAEGMSYLEEQRVVHRD Tec__BTK -------------------------------FQTQQLLEMCKDVCEAMEYLESKQFLHRD Tec__BMX -------------------------------LEPSQLLEMCYDVCEGMAFLESHQFIHRD Tec__TEC -------------------------------FSRDVLLSMCQDVCEGMEYLERNSFIHRD Tec__TXK -------------------------------LRKEMLLSVCQDICEGMEYLERNGYIHRD Tec__ITK -------------------------------FAAETLLGMCLDVCEGMAYLEEACVIHRD Csk__CSK -----------------S------------VLGGDCLLKFSLDVCEAMEYLEGNNFVHRD Csk__CTK -----------------A------------LVNTAQLLQFSLHVAEGMEYLESKKLVHRD Fer__FER -----------------D------------ELKLKQLVKFSLDAAAGMLYLESKNCIHRD Fer__FES -----------------A------------RLRVKTLLQMVGDAAAGMEYLESKCCIHRD FGFR__FGFR2 -----EYSYDINRVPEEQ-------------MTFKDLVSCTYQLARGMEYLASQKCIHRD FGFR__FGFR3 -----DYSFDTCKPPEEQ-------------LTFKDLVSCAYQVARGMEYLASQKCIHRD FGFR__FGFR1 -----EYCYNPSHNPEEQ-------------LSSKDLVSCAYQVARGMEYLASKKCIHRD FGFR__FGFR4 -----DLSPDGPRSSEGP-------------LSFPVLVSCAYQVARGMQYLESRKCIHRD Ret__RET S----RNSSSLDHPDERA-------------LTMGDLISFAWQISQGMQYLAEMKLVHRD VEGFR__KDR E----EKSLSDVEEEEAPED--LYKD----FLTLEHLICYSFQVAKGMEFLASRKCIHRD VEGFR__FLT1 E----DKSLSDVEEEEDSDG--FYKE----PITMEDLISYSFQVARGMEFLSSRKCIHRD VEGFR__FLT4 T----EGGARRASPDQEAED--LWLS----PLTMEDLVCYSFQVARGMEFLASRKCIHRD PDGFR__FMS V---STSSN--DSFSEQDLD----KEDGR-PLELRDLLHFSSQVAQGMAFLASKNCIHRD PDGFR__KIT D---KRRSVRIGSYIERDVTPAIMEDDEL-ALDLEDLLSFSYQVAKGMAFLASKNCIHRD PDGFR__PDGFRa SLYDRPASYKKKSMLDSEVKNLLSDDNSE-GLTLLDLLSFTYQVARGMEFLASKNCVHRD PDGFR__PDGFRb SNYMAPYDNYVPSAPERTCRATLINE-SP-VLSYMDLVGFSYQVANGMEFLASKNCVHRD PDGFR__FLT3 ISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRD Tie__TIE2 -----DPAFAIANSTAST-------------LSSQQLLHFAADVARGMDYLSQKQFIHRD Tie__TIE1 -----DPAFAREHGTAST-------------LSSRQLLRFASDAANGMQYLSEKQFIHRD Axl__AXL -------------Q--P------------VYLPTQMLVKFMADIASGMEYLSTKRFIHRD Axl__MER -------------G--P------------KHIPLQTLLKFMVDIALGMEYLSNRNFLHRD Axl__TYRO3 -------------N--P------------FNLPLQTLIRFMVDIACGMEYLSSRNFIHRD Met__MET ----------------T------------HNPTVKDLIGFGLQVAKAMKYLASKKFVHRD Met__RON ----------------Q------------RNPTVKDLISFGLQVARGMEYLAEQKFVHRD Ryk__RYK -------------ANNP------------QAISQQDLVHMAIQIACGMSYLARREVIHKD Alk__ALK -------------SQPS-------------SLAMLDLLHVARDIACGCQYLEENHFIHRD Alk__LTK -------------GQPS-------------PLVMRDLLQLAQDIAQGCHYLEENHFIHRD Sev__ROS -------------FYGP-------------LLTLVDLVDLCVDISKGCVYLERMHFIHRD InsR__INSR -------------ENNPG----R------PPPTLQEMIQMAAEIADGMAYLNAKKFVHRD InsR__IGF1R -------------ENNPV----L------APPSLSKMIQMAGEIADGMAYLNANKFVHRD InsR__IRR -------------ENNPG----L------PQPALGEMIQMAGEIADGMAYLAANKFVHRD JakB__Domain2_JAK1 ------------------------------VLTTPWKFKVAKQLASALSYLEDKDLVHGN JakB__Domain2_TYK2 ------------------------------HVPMAWKMVVAQQLASALSYLENKNLVHGN JakB__Domain2_JAK2 ------------------------------CINILWKLEVAKQLAWAMHFLEENTLIHGN JakB__Domain2_JAK3 ------------------------------LVPASWKLQVVKQLAYALNYLEDKGLPHGN TK-Unique__SuRTK106 ---------------------------LLYDLTEKQVYHIGKQVLLALEFLQEKHLFHGD . : * . Lmr__LMR1 LALRNCLLTADL--------TVKIGDYGLAHCKYR---EDY--FVTADQLWVPLRWIAPE Lmr__LMR3 LALRNCLLTSDL--------TVRIGDYGLAHSNYK---EDY--YLTPERLWIPLRWAAPE Lmr__LMR2 LALRNCFLTSDL--------NVKVGDYGIGFSRYK---EDY--IETDDKKVFPLRWTAPE CCK4__CCK4 LAARNCLVSAQR--------QVKVSALGLSKDVYN---SEY--YHFR-QAWVPLRWMSPE Ack__ACK LAARNLLLATRD--------LVKIGDFGLMRALPQN--DDH--YVMQEHRKVPFAWCAPE Ack__TNK1 LATRNLQLASPR--------TIKVADFGLVRPLGGA--RGR--YVMGGPRPIPYTWCAPE EGFR__EGFR LAARNVLVKTPQ--------HVKITDFGLAKLLGAE--EKE--YHAEG-GKVPIKWMALE EGFR__HER2/ErbB2 LAARNVLVKSPN--------HVKITDFGLARLLDID--ETE--YHADG-GKVPIKWMALE EGFR__HER4/ErbB4 LAARNVLVKSPN--------HVKITDFGLARLLEGD--EKE--YNADG-GKMPIKWMALE EGFR__HER3/ErbB3 LAARNVLLKSPS--------QVQVADFGVADLLPPD--DKQ--LLYSE-AKTPIKWMALE JakA__JAK1 LAARNVLVESEH--------QVKIGDFGLTKAIETD--KEY--YTVKDDRDSPVFWYAPE JakA__TYK2 LAARNVLLDNDR--------LVKIGDFGLAKAVPEG--HEY--YRVREDGDSPVFWYAPE JakA__JAK2 LATRNILVENEN--------RVKIGDFGLTKVLPQD--KEY--YKVKEPGESPIFWYAPE JakA__JAK3 LAARNILVESEA--------HVKIADFGLAKLLPLD--KDY--YVVREPGQSPIFWYAPE Syk__SYK LAARNVLLVTQH--------YAKISDFGLSKALRAD--ENY--YKAQTHGKWPVKWYAPE Syk__ZAP70 LAARNVLLVNRH--------YAKISDFGLSKALGAD--DSY--YTARSAGKWPLKWYAPE Fak__FAK IAARNVLVSSND--------CVKLGDFGLSRYME-D--STY--YKASK-GKLPIKWMAPE Fak__PYK2 IAVRNILVASPE--------CVKLGDFGLSRYIE-D--EDY--YKASV-TRLPIKWMSPE Eph__EphA3 LAARNILINSNL--------VCKVSDFGLSRVLEDDP-EAA--YTTR-GGKIPIRWTSPE Eph__EphA5 LAARNILINSNL--------VCKVSDFGLSRVLEDDP-EAA--YTTR-GGKIPIRWTAPE Eph__EphA4 LAARNILVNSNL--------VCKVSDFGMSRVLEDDP-EAA--YTTR-GGKIPIRWTAPE Eph__EphA6 LAARNILVNSNL--------VCKVSDFGLSRVLEDDP-EAA--YTTT-GGKIPIRWTAPE Eph__EphA7 LAARNILVNSNL--------VCKVSDFGLSRVIEDDP-EAV--YTTT-GGKIPVRWTAPE Eph__EphB1 LAARNILVNSNL--------VCKVSDFGLSRYLQDDTSDPT--YTSSLGGKIPVRWTAPE Eph__EphB2 LAARNILVNSNL--------VCKVSDFGLSRFLEDDTSDPT--YTSALGGKIPIRWTAPE Eph__EphB3 LAARNILVNSNL--------VCKVSDFGLSRFLEDDPSDPT--YTSSLGGKIPIRWTAPE Eph__EphB4 LAARNILVNSNL--------VCKVSDFGLSRFLEENSSDPT--YTSSLGGKIPIRWTAPE Eph__EphA8 LAARNVLVDSNL--------VCKVSDFGLSRVLEDDP-DAA--YTTT-GGKIPIRWTAPE Eph__EphA2 LAARNILVNSNL--------VCKVSDFGLSRVLEDDP-EAT--YTTS-GGKIPIRWTAPE Eph__EphA1 LAARNILVNQNL--------CCKVSDFGLTRLLDD--FDGT--YETQ-GGKIPIRWTAPE Eph__EphB6 LSAHSVLVNSHL--------VCKVARLGHSPQGPS----------------CLLRWAAPE Eph__EphA10 LAARHVLVSSDL--------VCKISGFGRGPRDRSE---AV--YTTM-SGRSPALWAAPE DDR__DDR1 LATRNCLVGENF--------TIKIADFGMSRNLYAG---DY--YRVQGRAVLPIRWMAWE DDR__DDR2 LATRNCLVGKNY--------TIKIADFGMSRNLYSG---DY--YRIQGRAVLPIRWMSWE Trk__TRKB LATRNCLVGENL--------LVKIGDFGMSRDVYST---DY--YRVGGHTMLPIRWMPPE Trk__TRKC LATRNCLVGANL--------LVKIGDFGMSRDVYST---DY--YRVGGHTMLPIRWMPPE Trk__TRKA LATRNCLVGQGL--------VVKIGDFGMSRDIYST---DY--YRVGGRTMLPIRWMPPE Musk__MUSK LATRNCLVGENM--------VVKIADFGLSRNIYSA---DY--YKANENDAIPIRWMPPE Ror__ROR1 LAARNILIGEQL--------HVKISDLGLSREIYSA---DY--YRVQSKSLLPIRWMPPE Ror__ROR2 LATRNVLVYDKL--------NVKISDLGLFREVYAA---DY--YKLLGNSLLPIRWMAPE Abl__ABL LAARNCLVGENH--------LVKVADFGLSRLMTG---DT---YTAHAGAKFPIKWTAPE Abl__ARG LAARNCLVGENH--------VVKVADFGLSRLMTG---DT---YTAHAGAKFPIKWTAPE Src__HCK LRAANILVSASL--------VCKIADFGLARVIE----DNE--YTAREGAKFPIKWTAPE Src__LYN LRAANVLVSESL--------MCKIADFGLARVIE----DNE--YTAREGAKFPIKWTAPE Src__LCK LRAANILVSDTL--------SCKIADFGLARLIE----DNE--YTAREGAKFPIKWTAPE Src__BLK LRAANILVSEAL--------CCKIADFGLARIID----S-E--YTAQEGAKFPIKWTAPE Src__SRC LRAANILVGENL--------VCKVADFGLARLIE----DNE--YTARQGAKFPIKWTAPE Src__YES LRAANILVGENL--------VCKIADFGLARLIE----DNE--YTARQGAKFPIKWTAPE Src__FYN LRSANILVGNGL--------ICKIADFGLARLIE----DNE--YTARQGAKFPIKWTAPE Src__FGR LRAANILVGERL--------ACKIADFGLARLIK----DDE--YNPCQGSKFPIKWTAPE Src__FRK LAARNVLVGEHN--------IYKVADFGLARVFKV---DNEDIYESRHEIKLPVKWTAPE Src__BRK LAARNILVGENT--------LCKVGDFGLARLIKE---D---VY-LSHDHNIPYKWTAPE Src__SRM LAARNVLVDDGL--------ACKVADFGLARLLKD---D---IYSPSSSSKIPVKWTAPE Tec__BTK LAARNCLVNDQG--------VVKVSDFGLSRYVLD---DE---YTSSVGSKFPVRWSPPE Tec__BMX LAARNCLVDRDL--------CVKVSDFGMTRYVLD---DQ---YVSSVGTKFPVKWSAPE Tec__TEC LAARNCLVSEAG--------VVKVSDFGMARYFLD---DQ---YTSSSGAKFPVKWCPPE Tec__TXK LAARNCLVSSTC--------IVKISDFGMTRYVLD---DE---YVSSFGAKFPIKWSPPE Tec__ITK LAARNCLVGENQ--------VIKVSDFGMTRFVLD---DQ---YTSSTGTKFPVKWASPE Csk__CSK LAARNVLVSEDN--------VAKVSDFGLTKEASS---TQD--TG-----KLPVKWTAPE Csk__CTK LAARNILVSEDL--------VAKVSDFGLAKAERK---GLD--SS-----RLPVKWTAPE Fer__FER LAARNCLVGENN--------VLKISDFGMSRQEDG---GVY--SSSG-LKQIPIKWTAPE Fer__FES LAARNCLVTEKN--------VLKISDFGMSREEAD---GVY--AASGGSRQVPVKWTAPE FGFR__FGFR2 LAARNVLVTENN--------VMKIADFGLARDINN---IDY--YKKTTNGRLPVKWMAPE FGFR__FGFR3 LAARNVLVTEDN--------VMKIADFGLARDVHN---LDY--YKKTTNGRLPVKWMAPE FGFR__FGFR1 LAARNVLVTEDN--------VMKIADFGLARDIHH---IDY--YKKTTNGRLPVKWMAPE FGFR__FGFR4 LAARNVLVTEDN--------VMKIADFGLARGVHH---IDY--YKKTSNGRLPVKWMAPE Ret__RET LAARNILVAEGR--------KMKISDFGLSRDVYE---EDS--YVKRSQGRIPVKWMAIE VEGFR__KDR LAARNILLSEKN--------VVKICDFGLARDIYK---DPD--YVRKGDARLPLKWMAPE VEGFR__FLT1 LAARNILLSENN--------VVKICDFGLARDIYK---NPD--YVRKGDTRLPLKWMAPE VEGFR__FLT4 LAARNILLSESD--------VVKICDFGLARDIYK---DPD--YVRKGSARLPLKWMAPE PDGFR__FMS VAARNVLLTNGH--------VAKIGDFGLARDIMN---DSN--YIVKGNARLPVKWMAPE PDGFR__KIT LAARNILLTHGR--------ITKICDFGLARDIKN---DSN--YVVKGNARLPVKWMAPE PDGFR__PDGFRa LAARNVLLAQGK--------IVKICDFGLARDIMH---DSN--YVSKGSTFLPVKWMAPE PDGFR__PDGFRb LAARNVLICEGK--------LVKICDFGLARDIMR---DSN--YISKGSTFLPLKWMAPE PDGFR__FLT3 LAARNVLVTHGK--------VVKICDFGLARDIMS---DSN--YVVRGNARLPVKWMAPE Tie__TIE2 LAARNILVGENY--------VAKIADFGLSR---G---QEV--YVKKTMGRLPVRWMAIE Tie__TIE1 LAARNVLVGENL--------ASKIADFGLSR---G---EEV--YVKKTMGRLPVRWMAIE Axl__AXL LAARNCMLNENM--------SVCVADFGLSKKIYN---GDYY--RQGRIAKMPVKWIAIE Axl__MER LAARNCMLRDDM--------TVCVADFGLSKKIYS---GDYY--RQGRIAKMPVKWIAIE Axl__TYRO3 LAARNCMLAEDM--------TVCVADFGLSRKIYS---GDYY--RQGCASKLPVKWLALE Met__MET LAARNCMLDEKF--------TVKVADFGLARDMYD---KEYYSVHNKTGAKLPVKWMALE Met__RON LAARNCMLDESF--------TVKVADFGLARDILD---REYYSVQQHRHARLPVKWMALE Ryk__RYK LAARNCVIDDTL--------QVKITDNALSRDLFP---MDYH--CLGDNENRPVRWMALE Alk__ALK IAARNCLLTCPG-----PGRVAKIGDFGMARDIYR---ASYY--RKGGCAMLPVKWMPPE Alk__LTK IAARNCLLSCAG-----PSRVAKIGDFGMARDIYR---ASYY--RRGDRALLPVKWMPPE Sev__ROS LAARNCLVSVKDY---TSPRIVKIGDFGLARDIYK---NDYY--RKRGEGLLPVRWMAPE InsR__INSR LAARNCMVAHDF--------TVKIGDFGMTRDIYE---TDYY--RKGGKGLLPVRWMAPE InsR__IGF1R LAARNCMVAEDF--------TVKIGDFGMTRDIYE---TDYY--RKGGKGLLPVRWMSPE InsR__IRR LAARNCMVSQDF--------TVKIGDFGMTRDVYE---TDYY--RKGGKGLLPVRWMAPE JakB__Domain2_JAK1 VCTKNLLLAREG-IDSECGPFIKLSDPGIPITVLS-----------RQECIERIPWIAPE JakB__Domain2_TYK2 VCGRNILLARLG-LAEGTSPFIKLSDPGVGLGALS-----------REERVERIPWLAPE JakB__Domain2_JAK2 VCAKNILLIREEDRKTGNPPFIKLSDPGISITVLP-----------KDILQERIPWVPPE JakB__Domain2_JAK3 VSARKVLLAREG--ADGSPPFIKLSDPGVSPAVLS-----------LEMLTDRIPWVAPE TK-Unique__SuRTK106 VAARNILMQSDL--------TAKLCGLGLAYEVYTRG-------AISSTQTIPLKWLAPE : : : . * . * Lmr__LMR1 LVDEVHSNLLVVDQTKSGNVWSLGVTIWELFELGT-QPYPQ---------------HSD- Lmr__LMR3 LLGELHGTFMVMDQSRESNIWSLGVTLWELFEFGA-QPYRH---------------LSD- Lmr__LMR2 LVTSFQDRLLTADQTKYSNIWSLGVTLWELFDNAA-QPYSN---------------LSN- CCK4__CCK4 AILEG-------DFSTKSDVWAFGVLMWEVFTHGE-MPHGG---------------QAD- Ack__ACK SLKTR-------TFSHASDTWMFGVTLWEMFTYGQ-EPWIG---------------LNG- Ack__TNK1 SLRHG-------AFSSASDVWMFGVTLWEMFSGGE-EPWPG---------------VPP- EGFR__EGFR SILHR-------IYTHQSDVWSYGVTVWELMTFGS-KPYDG---------------IPA- EGFR__HER2/ErbB2 SILRR-------RFTHQSDVWSYGVTVWELMTFGA-KPYDG---------------IPA- EGFR__HER4/ErbB4 CIHYR-------KFTHQSDVWSYGVTIWELMTFGG-KPYDG---------------IPT- EGFR__HER3/ErbB3 SIHFG-------KYTHQSDVWSYGVTVWELMTFGA-EPYAG---------------LRL- JakA__JAK1 CLMQS-------KFYIASDVWSFGVTLHELLTYCD-SDSSPMALFLKMIGPTH-GQMTV- JakA__TYK2 CLKEY-------KFYYASDVWSFGVTLYELLTHCD-SSQSPPTKFLELIGIAQ-GQMTV- JakA__JAK2 SLTES-------KFSVASDVWSFGVVLYELFTYIE-KSKSPPAEFMRMIGNDKQGQMIV- JakA__JAK3 SLSDN-------IFSRQSDVWSFGVVLYELFTYCD-KSCSPSAEFLRMMGCER-DVPAL- Syk__SYK CINYY-------KFSSKSDVWSFGVLMWEAFSYGQ-KPYRG---------------MKG- Syk__ZAP70 CINFR-------KFSSRSDVWSYGVTMWEALSYGQ-KPYKK---------------MKG- Fak__FAK SINFR-------RFTSASDVWMFGVCMWEILMHGV-KPFQG---------------VKN- Fak__PYK2 SINFR-------RFTTASDVWMFAVCMWEILSFGK-QPFFW---------------LEN- Eph__EphA3 AIAYR-------KFTSASDVWSYGIVLWEVMSYGE-RPYWE---------------MSN- Eph__EphA5 AIAFR-------KFTSASDVWSYGIVMWEVVSYGE-RPYWE---------------MTN- Eph__EphA4 AIAYR-------KFTSASDVWSYGIVMWEVMSYGE-RPYWD---------------MSN- Eph__EphA6 AIAYR-------KFSSASDAWSYGIVMWEVMSYGE-RPYWE---------------MSN- Eph__EphA7 AIQYR-------KFTSASDVWSYGIVMWEVMSYGE-RPYWD---------------MSN- Eph__EphB1 AIAYR-------KFTSASDVWSYGIVMWEVMSFGE-RPYWD---------------MSN- Eph__EphB2 AIQYR-------KFTSASDVWSYGIVMWEVMSYGE-RPYWD---------------MTN- Eph__EphB3 AIAYR-------KFTSASDVWSYGIVMWEVMSYGE-RPYWD---------------MSN- Eph__EphB4 AIAFR-------KFTSASDAWSYGIVMWEVMSFGE-RPYWD---------------MSN- Eph__EphA8 AIAFR-------TFSSASDVWSFGVVMWEVLAYGE-RPYWN---------------MTN- Eph__EphA2 AISYR-------KFTSASDVWSFGIVMWEVMTYGE-RPYWE---------------LSN- Eph__EphA1 AIAHR-------IFTTASDVWSFGIVMWEVLSFGD-KPYGE---------------MSN- Eph__EphB6 VIAHG-------KHTTSSDVWSFGILMWEVMSYGE-RPYWD---------------MSE- Eph__EphA10 TLQFG-------HFSSASDVWSFGIIMWEVMAFGE-RPYWD---------------MSG- DDR__DDR1 CILMG-------KFTTASDVWAFGVTLWEVLMLCRAQPFGQ---------------LTD- DDR__DDR2 SILLG-------KFTTASDVWAFGVTLWETFTFCQEQPYSQ---------------LSD- Trk__TRKB SIMYR-------KFTTESDVWSLGVVLWEIFTYGK-QPWYQ---------------LSN- Trk__TRKC SIMYR-------KFTTESDVWSFGVILWEIFTYGK-QPWFQ---------------LSN- Trk__TRKA SILYR-------KFTTESDVWSFGVVLWEIFTYGK-QPWYQ---------------LSN- Musk__MUSK SIFYN-------RYTTESDVWAYGVVLWEIFSYGL-QPYYG---------------MAH- Ror__ROR1 AIMYG-------KFSSDSDIWSFGVVLWEIFSFGL-QPYYG---------------FSN- Ror__ROR2 AIMYG-------KFSIDSDIWSYGVVLWEVFSYGL-QPYCG---------------YSN- Abl__ABL SLAYN-------KFSIKSDVWAFGVLLWEIATYGM-SPYPG---------------IDL- Abl__ARG SLAYN-------TFSIKSDVWAFGVLLWEIATYGM-SPYPG---------------IDL- Src__HCK AINFG-------SFTIKSDVWSFGILLMEIVTYGR-IPYPG---------------MSN- Src__LYN AINFG-------CFTIKSDVWSFGILLYEIVTYGK-IPYPG---------------RTN- Src__LCK AINYG-------TFTIKSDVWSFGILLTEIVTHGR-IPYPG---------------MTN- Src__BLK AYHFG-------VFTIKADVWSFGVLLMEVVTYGR-VPYPG---------------MSN- Src__SRC AALYG-------RFTIKSDVWSFGILLTELTTKGR-VPYPG---------------MVN- Src__YES AALYG-------RFTIKSDVWSFGILQTELVTKGR-VPYPG---------------MVN- Src__FYN AALYG-------RFTIKSDVWSFGILLTELVTKGR-VPYPG---------------MNN- Src__FGR AALFG-------RFTIKSDVWSFGILLTELITKGR-IPYPG---------------MNK- Src__FRK AIRSN-------KFSIKSDVWSFGILLYEIITYGK-MPYSG---------------MTG- Src__BRK ALSRG-------HYSTKSDVWSFGILLHEMFSRGQ-VPYPG---------------MSN- Src__SRM AANYR-------VFSQKSDVWSFGVLLHEVFTYGQ-CPYEG---------------MTN- Tec__BTK VLMYS-------KFSSKSDIWAFGVLMWEIYSLGK-MPYER---------------FTN- Tec__BMX VFHYF-------KYSSKSDVWAFGILMWEVFSLGK-QPYDL---------------YDN- Tec__TEC VFNYS-------RFSSKSDVWSFGVLMWEVFTEGR-MPFEK---------------YTN- Tec__TXK VFLFN-------KYSSKSDVWSFGVLMWEVFTEGK-MPFEN---------------KSN- Tec__ITK VFSFS-------RYSSKSDVWSFGVLMWEVFSEGK-IPYEN---------------RSN- Csk__CSK ALREK-------KFSTKSDVWSFGILLWEIYSFGR-VPYPR---------------IPL- Csk__CTK ALKHG-------KFTSKSDVWSFGVLLWEVFSYGR-APYPK---------------MSL- Fer__FER ALNYG-------RYSSESDVWSFGILLWETFSLGV-CPYPG---------------MTN- Fer__FES ALNYG-------RYSSESDVWSFGILLWETFSLGA-SPYPN---------------LSN- FGFR__FGFR2 ALFDR-------VYTHQSDVWSFGVLMWEIFTLGG-SPYPG---------------IPV- FGFR__FGFR3 ALFDR-------VYTHQSDVWSFGVLLWEIFTLGG-SPYPG---------------IPV- FGFR__FGFR1 ALFDR-------IYTHQSDVWSFGVLLWEIFTLGG-SPYPG---------------VPV- FGFR__FGFR4 ALFDR-------VYTHQSDVWSFGILLWEIFTLGG-SPYPG---------------IPV- Ret__RET SLFDH-------IYTTQSDVWSFGVLLWEIVTLGG-NPYPG---------------IPP- VEGFR__KDR TIFDR-------VYTIQSDVWSFGVLLWEIFSLGA-SPYPG---------------VKID VEGFR__FLT1 SIFDK-------IYSTKSDVWSYGVLLWEIFSLGG-SPYPG---------------VQMD VEGFR__FLT4 SIFDK-------VYTTQSDVWSFGVLLWEIFSLGA-SPYPG---------------VQIN PDGFR__FMS SIFDC-------VYTVQSDVWSYGILLWEIFSLGL-NPYPG---------------ILVN PDGFR__KIT SIFNC-------VYTFESDVWSYGIFLWELFSLGS-SPYPG---------------MPVD PDGFR__PDGFRa SIFDN-------LYTTLSDVWSYGILLWEIFSLGG-TPYPG---------------MMVD PDGFR__PDGFRb SIFNS-------LYTTLSDVWSFGILLWEIFTLGG-TPYPE---------------LPMN PDGFR__FLT3 SLFEG-------IYTIKSDVWSYGILLWEIFSLGV-NPYPG---------------IPVD Tie__TIE2 SLNYS-------VYTTNSDVWSYGVLLWEIVSLGG-TPYCG---------------MTC- Tie__TIE1 SLNYS-------VYTTKSDVWSFGVLLWEIVSLGG-TPYCG---------------MTC- Axl__AXL SLADR-------VYTSKSDVWSFGVTMWEIATRGQ-TPYPG---------------VEN- Axl__MER SLADR-------VYTSKSDVWAFGVTMWEIRTRGM-TPYPG---------------VQN- Axl__TYRO3 SLADN-------LYTVQSDVWAFGVTMWEIMTRGQ-TPYAG---------------IEN- Met__MET SLQTQ-------KFTTKSDVWSFGVVLWELMTRGA-PPYPD---------------VNT- Met__RON SLQTY-------RFTTKSDVWSFGVLLWELLTRGA-PPYRH---------------IDP- Ryk__RYK SLVNN-------EFSSASDVWAFGVTLWELMTLGQ-TPYVD---------------IDP- Alk__ALK AFMEG-------IFTSKTDTWSFGVLLWEIFSLGY-MPYPS---------------KSN- Alk__LTK AFLEG-------IFTSKTDSWSFGVLLWEIFSLGY-MPYPG---------------RTN- Sev__ROS SLMDG-------IFTTQSDVWSFGILIWEILTLGH-QPYPA---------------HSN- InsR__INSR SLKDG-------VFTTSSDMWSFGVVLWEITSLAE-QPYQG---------------LSN- InsR__IGF1R SLKDG-------VFTTYSDVWSFGVVLWEIATLAE-QPYQG---------------LSN- InsR__IRR SLKDG-------IFTTHSDVWSFGVVLWEIVTLAE-QPYQG---------------LSN- JakB__Domain2_JAK1 CVEDSKN------LSVAADKWSFGTTLWEICYNGE-IPLKD---------------KTL- JakB__Domain2_TYK2 CLPGGANS-----LSTAMDKWGFGATLLEICFDGE-APLQS---------------RSP- JakB__Domain2_JAK2 CIENPKN------LNLATDKWSFGTTLWEICSGGD-KPLSA---------------LDS- JakB__Domain2_JAK3 CLREAQT------LSLEADKWGFGATVWEVFSGVT-MPISA---------------LDP- TK-Unique__SuRTK106 RLLLR-------PASIRADVWSFGILLYEMVTLGA-PPYPE---------------VPP- : * . * Lmr__LMR1 QQVLA-----YTVREQQLKLPKPQLQLTLSDRWYE-VMQFCWLQ-PEQRPTAEEVHLLLS Lmr__LMR3 EEVLA-----FVVRQQHVKLARPKLKLPYADYWYD-ILQSCWRP-PAQRPSASDLQLQLT Lmr__LMR2 LDVLN-----QVIRERDTKLPKPQLEQPYSDRWYE-VLQFCWLS-PEKRPAAEDVHRLLT CCK4__CCK4 DEVLA-----DLQAG-KARLPQP---EGCPSKLYR-LMQRCWALSPKDRPSFSEIASAL- Ack__ACK SQILH-----KIDKEG-ERLPRP---EDCPQDIYN-VMVQCWAHKPEDRPTFVALRDFL- Ack__TNK1 YLILQ-----RLEDR--ARLPRP---PPSSRALYS-LALRCWAPHPADRPSFSHLEGLL- EGFR__EGFR SEISS-----ILEKG--ERLPQP---PICTIDVYM-IMVKCWMIDADSRPKFRELIIEFS EGFR__HER2/ErbB2 REIPD-----LLEKG--ERLPQP---PICTIDVYM-IMVKCWMIDSECRPRFRELVSEFS EGFR__HER4/ErbB4 REIPD-----LLEKG--ERLPQP---PICTIDVYM-VMVKCWMIDADSRPKFKELAAEFS EGFR__HER3/ErbB3 AEVPD-----LLEKG--ERLAQP---QICTIDVYM-VMVKCWMIDENIRPTFKELANEF- JakA__JAK1 TRLVN-----TLKEG--KRLPCP---PNCPDEVYQ-LMRKCWEFQPSNRTSFQNLIEGFE JakA__TYK2 LRLTE-----LLERG--ERLPRP---DKCPCEVYH-LMKNCWETEASFRPTF-------- JakA__JAK2 FHLIE-----LLKNN--GRLPRP---DGCPDEIYM-IMTECWNNNVNQRPSFRDLALRVD JakA__JAK3 CRLLE-----LLEEG--QRLPAP---PACPAEVHE-LMKLCWAPSPQDRPSFSALGPQLD Syk__SYK SEVTA-----MLEKG--ERMGCP---AGCPREMYD-LMNLCWTYDVENRPGF-------- Syk__ZAP70 PEVMA-----FIEQG--KRMECP---PECPPELYA-LMSDCWIYKWEDRPDFL------- Fak__FAK NDVIG-----RIENG--ERLPMP---PNCPPTLYS-LMTKCWAYDPSRRPRFTELKAQL- Fak__PYK2 KDVIG-----VLEKG--DRLPKP---DLCPPVLYT-LMTRCWDYDPSDRPRFTELVCSLS Eph__EphA3 QDVIK-----AVDEG--YRLPPP---MDCPAALYQ-LMLDCWQKDRNNRPKFEQIVSI-- Eph__EphA5 QDVIK-----AVEEG--YRLPSP---MDCPAALYQ-LMLDCWQKERNSRPKFDEIVNM-- Eph__EphA4 QDVIK-----AIEEG--YRLPPP---MDCPIALHQ-LMLDCWQKERSDRPKFGQIVNM-- Eph__EphA6 QDVIL-----SIEEG--YRLPAP---MGCPASLHQ-LMLHCWQKERNHRPKFTDIVSFL- Eph__EphA7 QDVIK-----AIEEG--YRLPAP---MDCPAGLHQ-LMLDCWQKERAERPKFEQIVGI-- Eph__EphB1 QDVIN-----AIEQD--YRLPPP---MDCPAALHQ-LMLDCWQKDRNSRPRFAEIVNTL- Eph__EphB2 QDVIN-----AIEQD--YRLPPP---MDCPSALHQ-LMLDCWQKDRNHRPKFGQIVNTL- Eph__EphB3 QDVIN-----AVEQD--YRLPPP---MDCPTALHQ-LMLDCWVRDRNLRPKFSQIVNTL- Eph__EphB4 QDVIN-----AIEQD--YRLPPP---PDCPTSLHQ-LMLDCWQKDRNARPRFPQVVSALD Eph__EphA8 RDVIS-----SVEEG--YRLPAP---MGCPHALHQ-LMLDCWHKDRAQRPRFSQIVSVL- Eph__EphA2 HEVMK-----AINDG--FRLPTP---MDCPSAIYQ-LMMQCWQQERARRPKFADIVSI-- Eph__EphA1 QEVMK-----SIEDG--YRLPPP---VDCPAPLYE-LMKNCWAYDRARRPHFQKLQAHLE Eph__EphB6 QEVLN-----AIEQE--FRLPPP---PGCPPGLHL-LMLDTWQKDRARRPHFDQLVAAF- Eph__EphA10 QDVIK-----AVEDG--FRLPPP---RNCPNLLHR-LMLDCWQKDPGERPRFSQIHSI-- DDR__DDR1 EQVIENAGEFFRDQGRQVYLSRP---PACPQGLYE-LMLRCWSRESEQRPPFSQLHRFL- DDR__DDR2 EQVIENTGEFFRDQGRQTYLPQP---AICPDSVYK-LMLSCWRRDTKNRPSFQEIHLLL- Trk__TRKB NEVIE-----CITQGR--VLQRP---RTCPQEVYE-LMLGCWQREPHMRKNIKGIHTLL- Trk__TRKC TEVIE-----CITQGR--VLERP---RVCPKEVYD-VMLGCWQREPQQRLNIKEIYKI-- Trk__TRKA TEAID-----CITQGR--ELERP---RACPPEVYA-IMRGCWQREPQQRHSIKDVHARLQ Musk__MUSK EEVIY-----YVRDGN--ILSCP---ENCPVELYN-LMRLCWSKLPADRPSFTSIHRI-- Ror__ROR1 QEVIE-----MVRKRQ--LLPCS---EDCPPRMYS-LMTECWNEIPSRRPRFKDIHVRLR Ror__ROR2 QDVVE-----MIRNRQ--VLPCP---DDCPAWVYA-LMIECWNEFPSRRPRFKDIHSRLR Abl__ABL SQVYE-----LLEKD--YRMERP---EGCPEKVYE-LMRACWQWNPSDRPSFAEIHQAF- Abl__ARG SQVYD-----LLEKG--YRMEQP---EGCPPKVYE-LMRACWKWSPADRPSFAETHQAF- Src__HCK PEVIR-----ALERG--YRMPRP---ENCPEELYN-IMMRCWKNRPEERPTFEYIQSVLD Src__LYN ADVMT-----ALSQG--YRMPRV---ENCPDELYD-IMKMCWKEKAEERPTFDYLQSVLD Src__LCK PEVIQ-----NLERG--YRMVRP---DNCPEELYQ-LMRLCWKERPEDRPTFDYLRSVLE Src__BLK PEVIR-----NLERG--YRMPRP---DTCPPELYRGVIAECWRSRPEERPTFEFLQSVLE Src__SRC REVLD-----QVERG--YRMPCP---PECPESLHD-LMCQCWRKEPEERPTFEYLQAF-- Src__YES REVLE-----QVERG--YRMPCP---QGCPESLHE-LMNLCWKKDPDERPTFEYIQSFL- Src__FYN REVLE-----QVERG--YRMPCP---QDCPISLHE-LMIHCWKKDPEERPTFEYLQSFL- Src__FGR REVLE-----QVEQG--YHMPCP---PGCPASLYE-AMEQTWRLDPEERPTFEYLQSFL- Src__FRK AQVIQ-----MLAQN--YRLPQP---SNCPQQFYN-IMLECWNAEPKERPTFETLRWKLE Src__BRK HEAFL-----RVDAG--YRMPCP---LECPPSVHK-LMLTCWCRDPEQRPCFKALRERLS Src__SRM HETLQ-----QIMRG--YRLPRP---AACPAEVYV-LMLECWRSSPEERPSFATLREKL- Tec__BTK SETAE-----HIAQG--LRLYRP---HLASEKVYT-IMYSCWHEKADERPTFKILLSNIL Tec__BMX SQVVL-----KVSQG--HRLYRP---HLASDTIYQ-IMYSCWHELPEKRPTFQQLLSSIE Tec__TEC YEVVT-----MVTRG--HRLYQP---KLASNYVYE-VMLRCWQEKPEGRPSFEDLLRTI- Tec__TXK LQVVE-----AISEG--FRLYRP---HLAPMSIYE-VMYSCWHEKPEGRPTFAELLRAVT Tec__ITK SEVVE-----DISTG--FRLYKP---RLASTHVYQ-IMNHCWKERPEDRPAFSRLLRQL- Csk__CSK KDVVP-----RVEKG--YKMDAP---DGCPPAVYE-VMKNCWHLDAAMRPSFLQLREQL- Csk__CTK KEVSE-----AVEKG--YRMEPP---EGCPGPVHV-LMSSCWEAEPARRPPFRKLAEKL- Fer__FER QQARE-----QVERG--YRMSAP---QHCPEDISK-IMMKCWDYKPENRPKFSELQKELT Fer__FES QQTRE-----FVEKG--GRLPCP---ELCPDAVFR-LMEQCWAYEPGQRPSFSTIYQELQ FGFR__FGFR2 EELFK-----LLKEG--HRMDKP---ANCTNELYM-MMRDCWHAVPSQRPTFKQLVEDL- FGFR__FGFR3 EELFK-----LLKEG--HRMDKP---ANCTHDLYM-IMRECWHAAPSQRPTFKQLVEDL- FGFR__FGFR1 EELFK-----LLKEG--HRMDKP---SNCTNELYM-MMRDCWHAVPSQRPTFKQLVEDL- FGFR__FGFR4 EELFS-----LLREG--HRMDRP---PHCPPELYG-LMRECWHAAPSQRPTFKQLVEAL- Ret__RET ERLFN-----LLKTG--HRMERP---DNCSEEMYR-LMLQCWKQEPDKRPVFADISKDLE VEGFR__KDR EEFCR-----RLKEG--TRMRAP---DYTTPEMYQ-TMLDCWHGEPSQRPTFSELVEHL- VEGFR__FLT1 EDFCS-----RLREG--MRMRAP---EYSTPEIYQ-IMLDCWHRDPKERPRFAELVEKL- VEGFR__FLT4 EEFCQ-----RLRDG--TRMRAP---ELATPAIRR-IMLNCWSGDPKARPAFSELVEIL- PDGFR__FMS SKFYK-----LVKDG--YQMAQP---AFAPKNIYS-IMQACWALEPTHRPTFQQICSFL- PDGFR__KIT SKFYK-----MIKEG--FRMLSP---EHAPAEMYD-IMKTCWDADPLKRPTFKQIVQLI- PDGFR__PDGFRa STFYN-----KIKSG--YRMAKP---DHATSEVYE-IMVKCWNSEPEKRPSFYHLSEIV- PDGFR__PDGFRb EQFYN-----AIKRG--YRMAQP---AHASDEIYE-IMQKCWEEKFEIRPPFSQLVLLL- PDGFR__FLT3 ANFYK-----LIQNG--FKMDQP---FYATEEIYI-IMQSCWAFDSRKRPSFPNLTSFL- Tie__TIE2 AELYE-----KLPQG--YRLEKP---LNCDDEVYD-LMRQCWREKPYERPSFAQILVSL- Tie__TIE1 AELYE-----KLPQG--YRMEQP---RNCDDEVYE-LMRQCWRDRPYERPPFAQIALQL- Axl__AXL SEIYD-----YLRQG--NRLKQP---ADCLDGLYA-LMSRCWELNPQDRPSFTELREDLE Axl__MER HEMYD-----YLLHG--HRLKQP---EDCLDELYE-IMYSCWRTDPLDRPTFSVLRL--- Axl__TYRO3 AEIYN-----YLIGG--NRLKQP---PECMEDVYD-LMYQCWSADPKQRPSF-------- Met__MET FDITV-----YLLQG--RRLLQP---EYCPDPLYE-VMLKCWHPKAEMRPSFSELVSRIS Met__RON FDLTH-----FLAQG--RRLPQP---EYCPDSLYQ-VMQQCWEADPAVRPTF-------- Ryk__RYK FEMAA-----YLKDG--YRIAQP---INCPDELFA-VMACCWALDPEERPKFQQLVQCL- Alk__ALK QEVLE-----FVTSG--GRMDPP---KNCPGPVYR-IMTQCWQHQPEDRPNFAIILERIE Alk__LTK QEVLD-----FVVGG--GRMDPP---RGCPGPVYR-IMTQCWQHEPELRPSFASILERLQ Sev__ROS LDVLN-----YVQTG--GRLEPP---RNCPDDLWN-LMTQCWAQEPDQRPTFHRIQNQL- InsR__INSR EQVLK-----FVMDG--GYLDQP---DNCPERVTD-LMRMCWQFNPNMRPTFLEIVNLL- InsR__IGF1R EQVLR-----FVMEG--GLLDKP---DNCPDMLFE-LMRMCWQYNPKMRPSFLEIISSIK InsR__IRR EQVLK-----FVMDG--GVLEEL---EGCPLQLQE-LMSRCWQPNPRLRPSFTHILDSIQ JakB__Domain2_JAK1 IEKER-----FYESR--CRPVTP------SCKELADLMTRCMNYDPNQRPFFRAIMRDIN JakB__Domain2_TYK2 SEKEH-----FYQRQ--HRLPEP------SCPQLATLTSQCLTYEPTQRPSFRTILRDL- JakB__Domain2_JAK2 QRKLQ-----FYEDR--HQLPAP------KWAELANLINNCMDYEPDFRPSFRAIIRDLN JakB__Domain2_JAK3 AKKLQ-----FYEDR--QQLPAP------KWTELALLIQQCMAYEPVQRPSFRAVIRDLN TK-Unique__SuRTK106 TSILE-----HLQRR--KIMKRP---SSCTHTMYS-IMKSCWRWREADRPSPRELRLRL- * Lmr__LMR1 YL----------------------------------------- Lmr__LMR3 YLLSERPPRPPPPPPPPRDGPFPWPWPPAHSAPRPGTLSSPFP Lmr__LMR2 YL----------------------------------------- CCK4__CCK4 ------------------------------------------- Ack__ACK ------------------------------------------- Ack__TNK1 ------------------------------------------- EGFR__EGFR ------------------------------------------- EGFR__HER2/ErbB2 ------------------------------------------- EGFR__HER4/ErbB4 ------------------------------------------- EGFR__HER3/ErbB3 ------------------------------------------- JakA__JAK1 AL----------------------------------------- JakA__TYK2 ------------------------------------------- JakA__JAK2 QI----------------------------------------- JakA__JAK3 MLWSGSRGCETHAFTAHPEGKHHSLS----------------- Syk__SYK ------------------------------------------- Syk__ZAP70 ------------------------------------------- Fak__FAK ------------------------------------------- Fak__PYK2 DVYQ--------------------------------------- Eph__EphA3 ------------------------------------------- Eph__EphA5 ------------------------------------------- Eph__EphA4 ------------------------------------------- Eph__EphA6 ------------------------------------------- Eph__EphA7 ------------------------------------------- Eph__EphB1 ------------------------------------------- Eph__EphB2 ------------------------------------------- Eph__EphB3 ------------------------------------------- Eph__EphB4 KMIRNPASLKIVARENGGASHPLL------------------- Eph__EphA8 ------------------------------------------- Eph__EphA2 ------------------------------------------- Eph__EphA1 QL----------------------------------------- Eph__EphB6 ------------------------------------------- Eph__EphA10 ------------------------------------------- DDR__DDR1 ------------------------------------------- DDR__DDR2 ------------------------------------------- Trk__TRKB ------------------------------------------- Trk__TRKC ------------------------------------------- Trk__TRKA AL----------------------------------------- Musk__MUSK ------------------------------------------- Ror__ROR1 SWEGLSSHTSSTTPSGGNATTQTTSLSASPVS----------- Ror__ROR2 AWGNLSNYNSSAQTSGASNTTQTSSLSTSPVS----------- Abl__ABL ------------------------------------------- Abl__ARG ------------------------------------------- Src__HCK ------------------------------------------- Src__LYN ------------------------------------------- Src__LCK ------------------------------------------- Src__BLK ------------------------------------------- Src__SRC ------------------------------------------- Src__YES ------------------------------------------- Src__FYN ------------------------------------------- Src__FGR ------------------------------------------- Src__FRK DYF---------------------------------------- Src__BRK SF----------------------------------------- Src__SRM ------------------------------------------- Tec__BTK D------------------------------------------ Tec__BMX P------------------------------------------ Tec__TEC ------------------------------------------- Tec__TXK E------------------------------------------ Tec__ITK ------------------------------------------- Csk__CSK ------------------------------------------- Csk__CTK ------------------------------------------- Fer__FER I------------------------------------------ Fer__FES S------------------------------------------ FGFR__FGFR2 ------------------------------------------- FGFR__FGFR3 ------------------------------------------- FGFR__FGFR1 ------------------------------------------- FGFR__FGFR4 ------------------------------------------- Ret__RET K------------------------------------------ VEGFR__KDR ------------------------------------------- VEGFR__FLT1 ------------------------------------------- VEGFR__FLT4 ------------------------------------------- PDGFR__FMS ------------------------------------------- PDGFR__KIT ------------------------------------------- PDGFR__PDGFRa ------------------------------------------- PDGFR__PDGFRb ------------------------------------------- PDGFR__FLT3 ------------------------------------------- Tie__TIE2 ------------------------------------------- Tie__TIE1 ------------------------------------------- Axl__AXL ------------------------------------------- Axl__MER ------------------------------------------- Axl__TYRO3 ------------------------------------------- Met__MET A------------------------------------------ Met__RON ------------------------------------------- Ryk__RYK ------------------------------------------- Alk__ALK Y------------------------------------------ Alk__LTK Y------------------------------------------ Sev__ROS ------------------------------------------- InsR__INSR ------------------------------------------- InsR__IGF1R E------------------------------------------ InsR__IRR E------------------------------------------ JakB__Domain2_JAK1 K------------------------------------------ JakB__Domain2_TYK2 ------------------------------------------- JakB__Domain2_JAK2 SLF---------------------------------------- JakB__Domain2_JAK3 SLISSDYELLSDPTP---------------------------- TK-Unique__SuRTK106 -------------------------------------------