CLUSTAL W (1.8) multiple sequence alignment RIPK__ANKRD3 FTGWEKVGSGGFG-QVYKVRHVH------W-KTWLAIKC-----------------SPSL RIPK__SgK288 ---WRLVASGGFS-QVFQARHRR------W-RTEYAIKC-----------------APCL RIPK__RIPK2 LADLRYLSRGASG-TVSSARHAD------W-RVQVAVKH-----------------LHIH RIPK__RIPK3 LENQELVGKDGFG-TVFRAQHRK------W-GYDVAVKI-----------------VNSK RIPK__RIPK1 FLESAELDSGGFG-KVSLCFHRT------Q-GLMIMKTV-----------------YKGP LISK_LIMK_LIMK2 LIHGEVLGKGFFG-QAIKVTHKA------T-GKVMVMKE-----------------LIRC LISK_LIMK_LIMK1 LIHGEVLGKGCFG-QAIKVTHRE------T-GEVMVMKE-----------------LIRF LISK_TESK_TESK1 FHCAEKIGAGFFS-EVYKVRHRQ------S-GQVMVLK-------------------MNK LISK_TESK_TESK2 ----EKIGSGFFS-EVFKVRHRA------S-GQVMALK-------------------MNT RAF__BRAF ITVGQRIGSGSFG-TVYKGKWHG------D-VAVKMLN------------------VTAP RAF__RAF1 VMLSTRIGSGSFG-TVYKGKWHG------D-VAVKILK------------------VVDP RAF__ARAF VQLLKRIGTGSFG-TVFRGRWHG------D-VAVKVLK------------------VSQP RAF__KSR1 VELGEPIGQGRWG-RVHRGRWHG------E-VAIRLLE------------------MDGH RAF__KSR2 LEIGELIGKGRFG-QVYHGRWHG------E-VAIRLID------------------IERD MLK_HH498_HH498 IEFHEIIGSGSFG-KVYKGRCRN------KIVAIKRYRAN----------------TYCS MLK_TAK1_TAK1 IEVEEVVGRGAFG-VVCKAKWRA------KDVAIKQIES--------------------- MLK_LZK_DLK ILDLQWVGSGAQG-AVFLGRFHG------EEVAVKKVRD--------------------- MLK_LZK_LZK ISELQWLGSGAQG-AVFLGKFRA------EEVAIKKVRE--------------------- MLK_MLK_MLK1 LTLEEIIGIGGFG-KVYRAFWIG------DEVAVKAARH--------------------- MLK_MLK_MLK3 LRLEEVIGIGGFG-KVYRGSWRG------ELVAVKAARQ--------------------- MLK_MLK_MLK4 LELKELIGAGGFG-QVYRATWQG------QEVAVKAARQ--------------------- MLK_MLK_MLK2 LQLEEIIGVGGFG-KVYRALWRG------EEVAVKAARL--------------------- MLK_MLK_ZAK LQFFENCGGGSFG-SVYRAKWIS------QDKEVAVKKL--------------------- STKR_Type1_ALK1 VALVECVGKGRYG-EVWRGLWHG------ESVAVKIFSS--------------------- STKR_Type1_ALK2 ITLLECVGKGRYG-EVWRGSWQG------ENVAVKIFSS--------------------- STKR_Type1_ALK4 IVLQEIIGKGRFG-EVWRGRWRG------GDVAVKIFSS--------------------- STKR_Type1_TGFbR1 IVLQESIGKGRFG-EVWRGKWRG------EEVAVKIFSS--------------------- STKR_Type1_ALK7 IVLQEIVGKGRFG-EVWHGRWCG------EDVAVKIFSS--------------------- STKR_Type1_BMPR1A IQMVRQVGKGRYG-EVWMGKWRG------EKVAVKVFFT--------------------- STKR_Type1_BMPR1B IQMVKQIGKGRYG-EVWMGKWRG------EKVAVKVFFT--------------------- STKR_Type2_ACTR2 LQLLEVKARGRFG-CVWKAQLLN------EYVAVKIFPI--------------------- STKR_Type2_ACTR2B LQLLEIKARGRFG-CVWKAQLMN------DFVAVKIFPL--------------------- STKR_Type2_TGFbR2 IELDTLVGKGRFA-EVYKAKLKQNTSEQFETVAVKIFPY--------------------- STKR_Type2_MISR2 LCFSQVIREGGHA-VVWAGQLQG------KLVAIKAFPP--------------------- STKR_Type2_BMPR2 LKLLELIGRGRYG-AVYKGSLDE------RPVAVKVFSF--------------------- LRRK__LRRK2 TVHGADHGDGSFG-SVYRAAYEG------EEVAVKIFN---------------------- LRRK__LRRK1 EDEGSVLGQGGSGTVIYRARYQG------QPVAVKRFHIKKFKNFANVPADTMLRHLRAT IRAK__IRAK1 FSEELKIGEGGFG-CVYRAVMRN------TVYAVKRLKE--------------------- IRAK__IRAK3 FHKDFLIGEGEIF-EVYRVEIQN------LTYAVKLFKQ--------------------- IRAK__IRAK2 FNQNRKISQGTFA-DVYRGHRHG------KPFVFKKLRE--------------------- IRAK__IRAK4 SVGGNKMGEGGFG-VVYKGYVNN------TTVAVKKLAA--------------------- MLK_ILK_ILK LNFLTKLNENHSG-ELWKGRWQG------NDIVVKVLKVR------------------DW TKL-Unique__MLKL -----LLRENEVS-TLYKGEYHR------APVAIKVFKK--------------------- . RIPK__ANKRD3 HVDDR---ERMELLEEAKKMEMAKFRYILPVYGICREP-------VGLVMEYMETGSLEK RIPK__SgK288 PPDAASS-DVNYLIEEAAKMKKIKFQHIVSIYGVCKQP-------LGIVMEFMANGSLEK RIPK__RIPK2 TPLLDS--ERKDVLREAEILHKARFSYILPILGICNEPE-----FLGIVTEYMPNGSLNE RIPK__RIPK3 AISRE----VK-AMASLDNEFVLRLEGVIEKVNWDQDPK------PALVTKFMENGSLSG RIPK__RIPK1 NCIEHN----EALLEEAKMMNRLRHSRVVKLLGVIIEEG-----KYSLVMEYMEKGNLMH LISK_LIMK_LIMK2 DEETQ-----KTFLTEVKVMRSLDHPNVLKFIGVLYKDK-----KLNLLTEYIEGGTLKD LISK_LIMK_LIMK1 DEETQ-----RTFLKEVKVMRCLEHPNVLKFIGVLYKDK-----RLNFITEYIKGGTLRG LISK_TESK_TESK1 LPSNR-----GNTLREVQLMNRLRHPNILRFMGVCVHQG-----QLHALTEYMNGGTLEQ LISK_TESK_TESK2 LSSNR-----ANMLKEVQLMNRLSHPNILR---------------------YINSGNLEQ RAF__BRAF TPQQL-----QAFKNEVGVLRKTRHVNILLFMG-YSTKP-----QLAIVTQWCEGSSLYH RAF__RAF1 TPEQF-----QAFRNEVAVLRKTRHVNILLFMG-YMTKD-----NLAIVTQWCEGSSLYK RAF__ARAF TAEQA-----QAFKNEMQVLRKTRHVNILLFMG-FMTRP-----GFAIITQWCEGSSLYH RAF__KSR1 NQDHL-----KLFKKEVMNYRQTRHENVVLFMGACMNPP-----HLAIITSFCKGRTLHS RAF__KSR2 NEDQL-----KAFKREVMAYRQTRHENVVLFMGACMSPP-----HLAIITSLCKGRTLYS MLK_HH498_HH498 KSDVD------MFCREVSILCQLNHPCVIQFVGACLNDPS----QFAIVTQYISGGSLFS MLK_TAK1_TAK1 ESERK------AFIVELRQLSRVNHPNIVKLYGACLN-------PVCLVMEYAEGGSLYN MLK_LZK_DLK LKETD-----------IKHLRKLKHPNIITFKGVCTQAP-----CYCILMEFCAQGQLYE MLK_LZK_LZK QNETD-----------IKHLRKLKHPNIIAFKGVCTQAP-----CYCIIMEYCAHGQLYE MLK_MLK_MLK1 DPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEP-----NLCLVMEFARGGPLNR MLK_MLK_MLK3 DPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEP-----NLCLVMEYAAGGPLSR MLK_MLK_MLK4 DPEQDAAAAAESVRREARLFAMLRHPNIIELRGVCLQQP-----HLCLVLEFARGGALNR MLK_MLK_MLK2 DPEKDPAVTAEQVCQEARLFGALQHPNIIALRGACLNPP-----HLCLVMEYARGGALSR MLK_MLK_ZAK LKIEK----------EAEILSVLSHRNIIQFYGVILEPP-----NYGIVTEYASLGSLYD STKR_Type1_ALK1 RDEQS-----WFRETEIYNTVLLRHDNILGFIASDMTSRN-SSTQLWLITHYHEHGSLYD STKR_Type1_ALK2 RDEKS-----WFRETELYNTVMLRHENILGFIASDMTSRH-SSTQLWLITHYHEMGSLYD STKR_Type1_ALK4 REERS-----WFREAEIYQTVMLRHENILGFIAADNKDNG-TWTQLWLVSDYHEHGSLFD STKR_Type1_TGFbR1 REERS-----WFREAEIYQTVMLRHENILGFIAADNKDNG-TWTQLWLVSDYHEHGSLFD STKR_Type1_ALK7 RDERS-----WFREAEIYQTVMLRHENILGFIAADNKDNG-TWTQLWLVSEYHEQGSLYD STKR_Type1_BMPR1A TEEAS-----WFRETEIYQTVLMRHENILGFIAADIKGTG-SWTQLYLITDYHENGSLYD STKR_Type1_BMPR1B TEEAS-----WFRETEIYQTVLMRHENILGFIAADIKGTG-SWTQLYLITDYHENGSLYD STKR_Type2_ACTR2 QDKQS-----WQNEYEVYSLPGMKHENILQFIGAEKRGTS-VDVDLWLITAFHEKGSLSD STKR_Type2_ACTR2B QDKQS-----WQSEREIFSTPGMKHENLLQFIAAEKRGSN-LEVELWLITAFHDKGSLTD STKR_Type2_TGFbR2 EEYAS-----WKTEKDIFSDINLKHENILQFLTAEERKTE-LGKQYWLITAFHAKGNLQE STKR_Type2_MISR2 RSVAQ-----FQAERALYELPGLQHDHIVRFITASRGGPGRLLSGPLLVLELHPKGSLCH STKR_Type2_BMPR2 ANRQN-----FINEKNIYRVPLMEHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCK LRRK__LRRK2 -KHTS----LRLLRQELVVLCHLHHPSLISLLAAGIRP-------RMLVMELASKGSLDR LRRK__LRRK1 DAMKN----FSEFRQEASMLHALQHPCIVALIGISIHP-------LCFALELAPLSSLNT IRAK__IRAK1 NADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNG-----FYCLVYGFLPNGSLED IRAK__IRAK3 EKKMQCKKHWKRFLSELEVLLLFHHPNILELAAYFTETE-----KFCLIYPYMRNGTLFD IRAK__IRAK2 TACSSPGSIERFFQAELQICLRCCHPNVLPVLGFCAARQ-----FHSFIYPYMANGSLQD IRAK__IRAK4 MVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGD-----DLCLVYVYMPNGSLLD MLK_ILK_ILK STRKS-----RDFNEECPRLRIFSHPNVLPVLGACQSPP---APHPTLITHWMPYGSLYN TKL-Unique__MLKL LQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTP-PQFSIVMEYCELGTLRE : * RIPK__ANKRD3 LLASEP---------------LPWDLRFRIIHETAVGMNFLHCMAP--------P-LLHL RIPK__SgK288 VLSTHS---------------LCWKLRFRIIHETSLAMNFLHSIKP--------P-LLHL RIPK__RIPK2 LLHRKTEY-----------PDVAWPLRFRILHEIALGVNYLHNMTP--------P-LLHH RIPK__RIPK3 LLQSQCP--------------RPWPLLCRLLKEVVLGMFYLHDQNP--------V-LLHR RIPK__RIPK1 VLKAEMS--------------TPLSVKGRIILEIIEGMCYLHGKG-----------VIHK LISK_LIMK_LIMK2 FLRSMD--------------PFPWQQKVRFAKGIASGMAYLHSMC-----------IIHR LISK_LIMK_LIMK1 IIKSMDS-------------QYPWSQRVSFAKDIASGMAYLHSMN-----------IIHR LISK_TESK_TESK1 LLSSPE--------------PLSWPVRLHLALDIARGLRYLHSKG-----------VFHR LISK_TESK_TESK2 LLDSNL--------------HLPWTVRVKLAYDIAVGLSYLHFKG-----------IFHR RAF__BRAF HLHIIET-------------KFEMIKLIDIARQTAQGMDYLHAKS-----------IIHR RAF__RAF1 HLHVQET-------------KFQMFQLIDIARQTAQGMDYLHAKN-----------IIHR RAF__ARAF HLHVADT-------------RFDMVQLIDVARQTAQGMDYLHAKN-----------IIHR RAF__KSR1 FVRDPKT-------------SLDINKTRQIAQEIIKGMGYLHAKG-----------IVHK RAF__KSR2 VVRDAKI-------------VLDVNKTRQIAQEIVKGMGYLHAKG-----------ILHK MLK_HH498_HH498 LLH-------------EQKRILDLQSKLIIAVDVAKGMEYLHNLT--------QP-IIHR MLK_TAK1_TAK1 VLHGA-----------EPLPYYTAAHAMSWCLQCSQGVAYLHSMQP-------KA-LIHR MLK_LZK_DLK VLRAG--------------RPVTPSLLVDWSMGIAGGMNYLH--LH-------K--IIHR MLK_LZK_LZK VLRAG--------------RKITPRLLVDWSTGIASGMNYLH--LH-------K--IIHR MLK_MLK_MLK1 VLSG---------------KRIPPDILVNWAVQIARGMNYLHDEAI-------VP-IIHR MLK_MLK_MLK3 ALAG---------------RRVPPHVLVNWAVQIARGMHYLHCEAL-------VP-VIHR MLK_MLK_MLK4 ALAAANAAPDPRAPGPRRARRIPPHVLVNWAVQIARGMLYLHEEAF-------VP-ILHR MLK_MLK_MLK2 VLAG---------------RRVPPHVLVNWAVQVARGMNYLHNDAP-------VP-IIHR MLK_MLK_ZAK YINSN------------RSEEMDMDHIMTWATDVAKGMHYLHMEAP-------VK-VIHR STKR_Type1_ALK1 FLQR---------------QTLEPHLALRLAVSAACGLAHLHVEIFGTQ---GKPAIAHR STKR_Type1_ALK2 YLQL---------------TTLDTVSCLRIVLSIASGLAHLHIEIFGTQ---GKPAIAHR STKR_Type1_ALK4 YLNR---------------YTVTIEGMIKLALSAASGLAHLHMEIVGTQ---GKPGIAHR STKR_Type1_TGFbR1 YLNR---------------YTVTVEGMIKLALSTASGLAHLHMEIVGTQ---GKPAIAHR STKR_Type1_ALK7 YLNR---------------NIVTVAGMIKLALSIASGLAHLHMEIVGTQ---GKPAIAHR STKR_Type1_BMPR1A FLKC---------------ATLDTRALLKLAYSAACGLCHLHTEIYGTQ---GKPAIAHR STKR_Type1_BMPR1B YLKS---------------TTLDAKSMLKLAYSSVSGLCHLHTEIFSTQ---GKPAIAHR STKR_Type2_ACTR2 FLKA---------------NVVSWNELCHIAETMARGLAYLHEDIPGLK-DGHKPAISHR STKR_Type2_ACTR2B YLKG---------------NIITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHR STKR_Type2_TGFbR2 YLTR---------------HVISWEDLRKLGSSLARGIAHLHSDHTPCG--RPKMPIVHR STKR_Type2_MISR2 YLTQ---------------YTSDWGSSLRMALSLAQGLAFLHEERWQNG--QYKPGIAHR STKR_Type2_BMPR2 YLSL---------------HTSDWVSSCRLAHSVTRGLAYLHTELPRGD--HYKPAISHR LRRK__LRRK2 LLQQDK-------------ASLTRTLQHRIALHVADGLRYLHSAM-----------IIYR LRRK__LRRK1 VLSENARD--------SSFIPLGHMLTQKIAYQIASGLAYLHKKN-----------IIFC IRAK__IRAK1 RLHCQTQACPP----------LSWPQRLDILLGTARAIQFLHQDSP---------SLIHG IRAK__IRAK3 RLQCVGDTAP-----------LPWHIRIGILIGISKAIHYLHNVQP--------CSVICG IRAK__IRAK2 RLQGQGGSDP-----------LPWPQRVSICSGLLCAVEYLHG-----------LEIIHS IRAK__IRAK4 RLSCLDGTPP-----------LSWHMRCKIAQGAANGINFLHEN-----------HHIHR MLK_ILK_ILK VLHEGTN------------FVVDQSQAVKFALDMARGMAFLHTLEP---------LIPRH TKL-Unique__MLKL LLDREK--------------DLTLGKRMVLVLGAARGLYRLHHSEAP---------ELHG : .: ** RIPK__ANKRD3 DLKPANILLDAH--------YHVKISDFGLAKCNGLS-H---------------SHDLSM RIPK__SgK288 DLKPGNILLDSN--------MHVKISDFGLSKWMEQSTR---------------MQYIER RIPK__RIPK2 DLKTQNILLDNE--------FHVKIADFGLSKWRMMSLS---------------QSRSSK RIPK__RIPK3 DLKPSNVLPDPE--------LHVKLADFGLSTFQGGS------------------QSGTG RIPK__RIPK1 DLKPENILVDND--------FHIKIADLGLASFKMWSKLNN-------EEHNELREVDGT LISK_LIMK_LIMK2 DLNSHNCLIKLDK--------TVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKK LISK_LIMK_LIMK1 DLNSHNCLVRENK--------NVVVADFGLARLMVDEKTQP------EGLRSLKKPDRKK LISK_TESK_TESK1 DLTSKNCLVRREDR-----GFTAVVGDFGLAEKIPVYREGA----------------RKE LISK_TESK_TESK2 DLTSKNCLIKRDEN-----GYSAVVADFGLAEKIPDVSMGS----------------EK- RAF__BRAF DLKSNNIFLHED--------LTVKIGDFGLATVKSRWSGSH------------------Q RAF__RAF1 DMKSNNIFLHEG--------LTVKIGDFGLATVKSRWSGSQ------------------Q RAF__ARAF DLKSNNIFLHEG--------LTVKIGDFGLATVKTRWSGAQ------------------P RAF__KSR1 DLKSKNVFYDNGKV------VITDFGLFGISGVVREGRREN------------------Q RAF__KSR2 DLKSKNVFYDNGKV------VITDFGLFSISGVLQAGRRED------------------K MLK_HH498_HH498 DLNSHNILLYE-------DGHAV-VADFGESRFLQSL--DED-----------------N MLK_TAK1_TAK1 DLKPPNLLLVA-------GGTVLKICDFGTACDIQT-----------------------H MLK_LZK_DLK DLKSPNMLITY-------DD-VVKISDFGTSKELSD----KS-----------------T MLK_LZK_LZK DLKSPNVLVTH-------TD-AVKISDFGTSKELSD----KS-----------------T MLK_MLK_MLK1 DLKSSNILILQKVENGDLSNKILKITDFGLAREWH-----RT-----------------T MLK_MLK_MLK3 DLKSNNILLLQPIESDDMEHKTLKITDFGLAREWH-----KT-----------------T MLK_MLK_MLK4 DLKSSNILLLEKIEHDDICNKTLKITDFGLAREWH-----RT-----------------T MLK_MLK_MLK2 DLKSINILILEAIENHNLADTVLKITDFGLAREWH-----KT-----------------T MLK_MLK_ZAK DLKSRNVVIAA-------DG-VLKICDFGASRFHN-----HT-----------------T STKR_Type1_ALK1 DFKSRNVLVKS--------NLQCCIADLGLAVMHSQ---GSD-------------YLDIG STKR_Type1_ALK2 DLKSKNILVKK--------NGQCCIADLGLAVMHSQ---STN-------------QLDVG STKR_Type1_ALK4 DLKSKNILVKK--------NGMCAIADLGLAVRHDA---VTD-------------TIDIA STKR_Type1_TGFbR1 DLKSKNILVKK--------NGTCCIADLGLAVRHDS---ATD-------------TIDIA STKR_Type1_ALK7 DIKSKNILVKK--------CETCAIADLGLAVKHDS---ILN-------------TIDIP STKR_Type1_BMPR1A DLKSKNILIKK--------NGSCCIADLGLAVKFNS---DTN-------------EVDVP STKR_Type1_BMPR1B DLKSKNILVKK--------NGTCCIADLGLAVKFIS---DTN-------------EVDIP STKR_Type2_ACTR2 DIKSKNVLLKN--------NLTACIADFGLALKFEA---GKS-------------AGD-- STKR_Type2_ACTR2B DFKSKNVLLKS--------DLTAVLADFGLAVRFEP---GKP-------------PGD-- STKR_Type2_TGFbR2 DLNSSNILVKN--------DLTCCLCDFGLSLRLDP---TLS-------------VDDLA STKR_Type2_MISR2 DLSSQNVLIRE--------DGSCAIGDLGLALVLPG--LTQPPAW------TPTQPQGPA STKR_Type2_BMPR2 DLNSRNVLVKN--------DGTCVISDFGLSMRLTGNRLVRP---------G---EEDNA LRRK__LRRK2 DLKPHNVLLFTLYPN---AAIIAKIADYGIAQYCCR----------------------MG LRRK__LRRK1 DLKSDNILVWSLDVK---EHINIKLSDYGISRQSFH----------------------EG IRAK__IRAK1 DIKSSNVLLDER--------LTPKLGDFGLARFSRFAG--SSP---------SQSSMVAR IRAK__IRAK3 SISSANILLDDQ--------FQPKLTDFAMAHFR--S---HLE---------HQSCTINM IRAK__IRAK2 NVKSSNVLLDQN--------LTPKLAHP-MAHLCP-----VNK---------RSKYTMMK IRAK__IRAK4 DIKSANILLDEA--------FTAKISDFGLARAS------------------EKFAQTVM MLK_ILK_ILK ALNSRSVMIDED------MTARISMADVKFSFQCPG------------------------ TKL-Unique__MLKL KIRSSNFLVTQG--------YQVKLAGFELRKTQTSMSLGTTR----------------E . . . . . RIPK__ANKRD3 DGLFG-TIAYLPPERIREKSR-------LFDTKHDVYSFAIVIWGVLTQ----------- RIPK__SgK288 SALRG-MLSYIPPEMFLESNK-------APGPKYDVYSFAIVIWELLTQ----------- RIPK__RIPK2 SAPEGGTIIYMPPENYEPGQKS------RASIKHDIYSYAVITWEVLSR----------- RIPK__RIPK3 SGEPGGTLGYLAPELFVNVNR-------KASTASDVYSFGILMWAVLAG----------- RIPK__RIPK1 AKKNGGTLYYMAPEHLNDVNA-------KPTEKSDVYSFAVVLWAIFAN----------- LISK_LIMK_LIMK2 RYTVVGNPYWMAPEMLNGK---------SYDETVDIFSFGIVLCEIIG------------ LISK_LIMK_LIMK1 RYTVVGNPYWMAPEMINGR---------SYDEKVDVFSFGIVLCEIIG------------ LISK_TESK_TESK1 PLAVVGSPYWMAPEVLRGE---------LYDEKADVFAFGIVLCELIA------------ LISK_TESK_TESK2 -LAVVGSPFWMAPEVLRDE---------PYNEKADVFSYGIILCEIIA------------ RAF__BRAF FEQLSGSILWMAPEVIRMQ------DKNPYSFQSDVYAFGIVLYELMTG----------- RAF__RAF1 VEQPTGSVLWMAPEVIRMQ------DNNPFSFQSDVYSYGIVLYELMTG----------- RAF__ARAF LEQPSGSVLWMAAEVIRMQ------DPNPYSFQSDVYAYGVVLYELMTG----------- RAF__KSR1 LKLSHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVYAFGTVWYELQAR----------- RAF__KSR2 LRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAR----------- MLK_HH498_HH498 MTKQPGNLRWMAPEVFTQCTR--YT---I---KADVFSYALCLWEILTG----------E MLK_TAK1_TAK1 MTNNKGSAAWMAPEVFEGSN---YS---E---KCDVFSWGIILWEVITR----------R MLK_LZK_DLK KMSFAGTVAWMAPEVIRNEP---VS---E---KVDIWSFGVVLWELLTG----------E MLK_LZK_LZK KMSFAGTVAWMAPEVIRNEP---VS---E---KVDIWSFGVVLWELLTG----------E MLK_MLK_MLK1 KMSAAGTYAWMAPEVIRASM---FS---K---GSDVWSYGVLLWELLTG----------E MLK_MLK_MLK3 QMSAAGTYAWMAPEVIKAST---FS---K---GSDVWSFGVLLWELLTG----------E MLK_MLK_MLK4 KMSTAGTYAWMAPEVIKSSL---FS---K---GSDIWSYGVLLWELLTG----------E MLK_MLK_MLK2 KMSAAGTYAWMAPEVIRLSL---FS---K---SSDVWSFGVLLWELLTG----------E MLK_MLK_ZAK HMSLVGTFPWMAPEVIQSLP---VS---E---TCDTYSYGVVLWEMLTR----------E STKR_Type1_ALK1 NNPRVGTKRYMAPEVLDEQIR--TDC-FESYKWTDIWAFGLVLWEIARRTIVN--G-IVE STKR_Type1_ALK2 NNPRVGTKRYMAPEVLDETIQ--VDC-FDSYKRVDIWAFGLVLWEVARRMVSN--G-IVE STKR_Type1_ALK4 PNQRVGTKRYMAPEVLDETIN--MKH-FDSFKCADIYALGLVYWEIARRCNSG--G-VHE STKR_Type1_TGFbR1 PNHRVGTKRYMAPEVLDDSIN--MKH-FESFKRADIYAMGLVFWEIARRCSIG--G-IHE STKR_Type1_ALK7 QNPKVGTKRYMAPEMLDDTMN--VNI-FESFKRADIYSVGLVYWEIARRCSVG--G-IVE STKR_Type1_BMPR1A LNTRVGTKRYMAPEVLDESLN--KNH-FQPYIMADIYSFGLIIWEMARRCITG--G-IVE STKR_Type1_BMPR1B PNTRVGTKRYMPPEVLDESLN--RNH-FQSYIMADMYSFGLILWEVARRCVSG--G-IVE STKR_Type2_ACTR2 THGQVGTRRYMAPEVLEGAIN--FQ--RDAFLRIDMYAMGLVLWELASRCTAA--DGPVD STKR_Type2_ACTR2B THGQVGTRRYMAPEVLEGAIN--FQ--RDAFLRIDMYAMGLVLWELVSRCKAA--DGPVD STKR_Type2_TGFbR2 NSGQVGTARYMAPEVLESRMN--LEN-AESFKQTDVYSMALVLWEMTSRCNAV--G-EVK STKR_Type2_MISR2 AIMEAGTQRYMAPELLDKTLD--LQDWGMALRRADIYSLALLLWEILSRCPDLRPDSSPP STKR_Type2_BMPR2 AISEVGTIRYMAPEVLEGAVN--LRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVP LRRK__LRRK2 IKTSEGTPGFRAPEVARGN--------VIYNQQADVYSFGLLLYDILTT--------G-- LRRK__LRRK1 ALGVEGTPGYQAPEIRP-R--------IVYDEKVDMFSYGMVLYELLS------------ IRAK__IRAK1 TQTVRGTLAYLPEEYIKTG---------RLAVDTDTFSFGVVVLETLAG----------- IRAK__IRAK3 TSSSSKHLWYMPEEYIRQG---------KLSIKTDVYSFGIVIMEVLTG----------- IRAK__IRAK2 THLLRTSAAYLPEDFIRVG---------QLTKRVDIFSCGIVLAEVLTG----------- IRAK__IRAK4 TSRIVGTTAYMAPEALR-G---------EITPKSDIYSFGVVLLEIITG----------- MLK_ILK_ILK ---RMYAPAWVAPEALQKKPE------DTNRRSADMWSFAVLLWELVTR----------- TKL-Unique__MLKL KTDRVKSTAYLSPQELEDVFY-------QYDVKSEIYSFGIVLWEIATG----------- . : : :: . RIPK__ANKRD3 --KKPFADE-KNILHIMVKVVKGHRPEL----PPVC------------------------ RIPK__SgK288 --KKPYSG--FNMMMIIIRVAAGMRPSL----QPVS------------------------ RIPK__RIPK2 --KQPFEDV-TNPLQIMYSVSQGHRPVI----NEES------------------------ RIPK__RIPK3 --REVELPT-EPSLVYEAVCNRQNRPSL----AELP------------------------ RIPK__RIPK1 --KEPYENA-ICEQQLIMCIKSGNRPDV----DDIT------------------------ LISK_LIMK_LIMK2 ------QVY-ADPDCLPRTLDFGLNVKL----FWEK------------------------ LISK_LIMK_LIMK1 ------RVN-ADPDYLPRTMDFGLNVRG----FLDR------------------------ LISK_TESK_TESK1 ------RVP-ADPDYLPRTEDFGLDVPA----FRT------------------------- LISK_TESK_TESK2 ------RIQ-ADPDYLPRTENFGLDYDA----FQH------------------------- RAF__BRAF --QLPYSNI-NNRDQIIFMVGRG-YLSP----DLSK------------------------ RAF__RAF1 --ELPYSHI-NNRDQIIFMVGRG-YASP----DLSK------------------------ RAF__ARAF --SLPYSHI-GCRDQIIFMVGRG-YLSP----DLSK------------------------ RAF__KSR1 --DWPLKNQ-A-AEASIWQIGSGEGMKR----VLTS------------------------ RAF__KSR2 --EWPFKTQ-P-AEAIIWQMGTG--MKP----NLSQ------------------------ MLK_HH498_HH498 ---IPFAHL-KPAAAAADMAYHH-IRPP----IGYS------------------------ MLK_TAK1_TAK1 ---KPFDEI-GGPAFRIMWAVHNGTRPP----LIKN------------------------ MLK_LZK_DLK ---IPYKDV-DSSAIIWGVGSNS-LHLP----VPSS------------------------ MLK_LZK_LZK ---IPYKDV-DSSAIIWGVGSNS-LHLP----VPST------------------------ MLK_MLK_MLK1 ---VPFRGI-DGLAVAYGVAMNK-LALP----IPST------------------------ MLK_MLK_MLK3 ---VPYRGI-DCLAVAYGVAVNK-LTLP----IPST------------------------ MLK_MLK_MLK4 ---VPYRGI-DGLAVAYGVAVNK-LTLP----IPST------------------------ MLK_MLK_MLK2 ---VPYREI-DALAVAYGVAMNK-LTLP----IPST------------------------ MLK_MLK_ZAK ---VPFKGL-EGLQVAWLVVEKN-ERLT----IPSS------------------------ STKR_Type1_ALK1 DYRPPFYDV-VPNDPSFEDMKKVVCVDQ----QTPT------------------------ STKR_Type1_ALK2 DYKPPFYDV-VPNDPSFEDMRKVVCVDQ----QRPN------------------------ STKR_Type1_ALK4 EYQLPYYDL-VPSDPSIEEMRKVVCDQK----LRPN------------------------ STKR_Type1_TGFbR1 DYQLPYYDL-VPSDPSVEEMRKVVCEQK----LRPN------------------------ STKR_Type1_ALK7 EYQLPYYDM-VPSDPSIEEMRKVVCDQK----FRPS------------------------ STKR_Type1_BMPR1A EYQLPYYNM-VPSDPSYEDMREVVCVKR----LRPI------------------------ STKR_Type1_BMPR1B EYQLPYHDL-VPSDPSYEDMREIVCIKK----LRPS------------------------ STKR_Type2_ACTR2 EYMLPFEEE-IGQHPSLEDMQEVVVHKK----KRPV------------------------ STKR_Type2_ACTR2B EYMLPFEEE-IGQHPSLEELQEVVVHKK----MRPT------------------------ STKR_Type2_TGFbR2 DYEPPFGSK-VREHPCVESMKDNVLRDR----GRPE------------------------ STKR_Type2_MISR2 PFQLAYEAE-LGNTPTSDELWALAVQER----RRPY------------------------ STKR_Type2_BMPR2 EYQMAFQTE-VGNHPTFEDMQVLVSREK----QRPK------------------------ LRRK__LRRK2 --GRIVEGL-KFPNEFDELEIQGKLPDP----VKEY------------------------ LRRK__LRRK1 -------GQ-RPALGHHQLQIAKKLSKG----IRPV------------------------ IRAK__IRAK1 --QRAVKTHGARTKYLKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIYKKHL IRAK__IRAK3 --CRVVLDD-PKHIQLRDLLRELMEKRG--LDSCLS----------------------FL IRAK__IRAK2 --IPAMDNN-RSPVYLKDLLLSEIPSSTASLCSRKTG--------------------VEN IRAK__IRAK4 --LPAVDEH-REPQLLLDIKEEIEDEEK----TIED----------------------YI MLK_ILK_ILK --EVPFADL-SNMEIGMKVALEG---------LRPT------------------------ TKL-Unique__MLKL --DIPFQG--CNSEKIRKLVAVKRQQEP----LGED------------------------ RIPK__ANKRD3 RARPR-----ACSHLIRLMQRCWQGDPRVRPTFQEITSETED------ RIPK__SgK288 DQWPS-----EAQQMVDLMKRCWDQDPKKRPCFL-------------- RIPK__RIPK2 LPYDIP----HRARMISLIESGWAQNPDERPSFL-------------- RIPK__RIPK3 QAGPETP---GLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVF---- RIPK__RIPK1 EYCPR--------EIISLMKLCWEANPEARPTFPGIEEKF-------- LISK_LIMK_LIMK2 FVPTD-----CPPAFFPLAAICCRLEPESRPAFSKLEDSF-------- LISK_LIMK_LIMK1 YCPPN-----CPPSFFPITVRCCDLDPEKRPSFVKLEHWL-------- LISK_TESK_TESK1 LVGDD-----CPLPFLLLAIHCCNLEPSTRAPFTEITQHLEWI----- LISK_TESK_TESK2 MVG-D-----CPPDFLQLTFNCCNMDPKLRPSFVEIGKTL-------- RAF__BRAF VRS-N-----CPKAMKRLMAECLKKKRDERPLFPQILASIEL------ RAF__RAF1 LYK-N-----CPKAMKRLVADCVKKVKEERPLFPQILSSIEL------ RAF__ARAF ISS-N-----CPKAMRRLLSDCLKFQREERPLFPQILATI-------- RAF__KSR1 VS--------LGKEVSEILSACWAFDLQERPSFSLLMDM--------- RAF__KSR2 IG--------MGKEISDILLFCWAFEQEERPTFTKLMDM--------- MLK_HH498_HH498 IPKPISS----------LLIRGWNACPEGRPEFSEVVMKLEECL---- MLK_TAK1_TAK1 LPKPIES----------LMTRCWSKDPSQRPSMEEIVKI--------- MLK_LZK_DLK CPDGFKI----------LLRQCWNSKPRNRPSFRQILLHL-------- MLK_LZK_LZK CPDGFKI----------LMKQTWQSKPRNRPSFRQTLMHL-------- MLK_MLK_MLK1 CPEPFAK----------LMEDCWNPDPHSRPSFTNILDQL-------- MLK_MLK_MLK3 CPEPFAQ----------LMADCWAQDPHRRPDFASILQQL-------- MLK_MLK_MLK4 CPEPFAK----------LMKECWQQDPHIRPSFALILEQL-------- MLK_MLK_MLK2 CPEPFAR----------LLEECWDPDPHGRPDFGSILKRLEVI----- MLK_MLK_ZAK CPRSFAE----------LLHQCWEADAKKRPSFKQIISI--------- STKR_Type1_ALK1 IPNRLAA-DPVLSGLAQMMRECWYPNPSARLTALRIKKTL-------- STKR_Type1_ALK2 IPNRWFS-DPTLTSLAKLMKECWYQNPSARLTALRIKKTL-------- STKR_Type1_ALK4 IPNWWQS-YEALRVMGKMMRECWYANGAARLTALRIKKTL-------- STKR_Type1_TGFbR1 IPNRWQS-CEALRVMAKIMRECWYANGAARLTALRIKKTL-------- STKR_Type1_ALK7 IPNQWQS-CEALRVMGRIMRECWYANGAARLTALRIKKTI-------- STKR_Type1_BMPR1A VSNRWNS-DECLRAVLKLMSECWAHNPASRLTALRIKKTL-------- STKR_Type1_BMPR1B FPNRWSS-DECLRQMGKLMTECWAHNPASRLTALRVKKTL-------- STKR_Type2_ACTR2 LRDYWQK-HAGMAMLCETIEECWDHDAEARLSA--------------- STKR_Type2_ACTR2B IKDHWLK-HPGLAQLCVTIEECWDHDAEARLSAGCVEERVSL------ STKR_Type2_TGFbR2 IPSFWLN-HQGIQMVCETLTECWDHDPEARLTAQCVAERFS------- STKR_Type2_MISR2 IPSTWRCFATDPDGLRELLEDCWDADPEARLTAECVQQRLAALAHPQE STKR_Type2_BMPR2 FPEAWKENSLAVRSLKETIEDCWDQDAEARLTAQCAEERMAELMMIWE LRRK__LRRK2 GCAP-------WPMVEKLIKQCLKENPQERPTSAQVFDI--------- LRRK__LRRK1 LGQPEEV---QFRRLQALMMECWDTKPEKRPLALSVVSQMKDPTF--- IRAK__IRAK1 DPRPGPCPPELGLGLGQLACCCLHRRAKRRPPMTQVYERLEKL----- IRAK__IRAK3 DKKVPPCPRNFSAKLFCLAGRCAATRAKLRPSMDEVLNTL-------- IRAK__IRAK2 VMAKEICQKYLEKGAGRLPEDCAEALATA------------------- IRAK__IRAK4 DKKMNDADSTSVEAMYSGASQCRHEKKNKSPDIKKVHQLL-------- MLK_ILK_ILK IPPGIS-----P-HVCKLMKICMNEDPAKRPKFDMIVPILEKM----- TKL-Unique__MLKL CPS----------ELREIIDECRAHDPSVRPSVDEILKKLSTF-----