Name	Accession	VAIK motif	K	HRD motif	DFG motif	Activity Prediction	HMM P score	Notes
AAK1	SK422	CALK	K	HRD	DFG	Active		
ABL	SK006	VAVK	K	HRD	DFG	Active		
ACK	SK009	VAVK	K	HRD	DFG	Active		
ACTR2	SK010	VAVK	K	HRD	DFG	Active		
ACTR2B	SK011	VAVK	K	HRD	DFG	Active		
AKT1	SK018	YAMK	K	YRD	DFG	Active		
AKT2	SK019	YAMK	K	YRD	DFG	Active		
AKT3	SK020	YAMK	K	YRD	DFG	Active		
ALK	SK024	VAVK	K	HRD	DFG	Active		
ALK1	SK025	VAVK	K	HRD	DLG	Active		
ALK2	SK026	VAVK	K	HRD	DLG	Active		
ALK4	SK028	VAVK	K	HRD	DLG	Active		
ALK7	SK405	VAVK	K	HRD	DLG	Active		
AMPKa1	SK032	VAVK	K	HRD	DFG	Active		
AMPKa2	SK033	VAVK	K	HRD	DFG	Active		
ANKRD3	SK546	LAIK	K	HLD	DFG	Active		
ARAF	SK036	VAVK	K	HRD	DFG	Active		
ARG	SK037	VAVK	K	HRD	DFG	Active		
ATM	SK038	QLVK	K	LGDRH	DLG	Active		HRD motif modified in PIKKs
ATR	SK039	MMCK	K	LGDRH	DFN	Active		HRD motif modified in PIKKs
AurA	SK407	LALK	K	HRD	DFG	Active		
AurB	SK406	VALK	K	HRD	DFG	Active		
AurC	SK043	VALK	K	HRD	DFG	Active		
AXL	SK044	VAVK	K	HRD	DFG	Active		
BARK1	SK045	YAMK	K	YRD	DLG	Active		
BARK2	SK478	YAMK	K	YRD	DLG	Active		
BIKE	SK704	CALK	K	HRD	DFG	Active		
BLK	SK049	VAIK	K	HRD	DFG	Active		
BMPR1A	SK027	VAVK	K	HRD	DLG	Active		
BMPR1B	SK030	VAVK	K	HRD	DLG	Active		
BMPR2	SK365	VAVK	K	HRD	DFG	Active		
BMX	SK417	VAVK	K	HRD	DFG	Active
BRAF	SK050	VAVK	K	HRD	DFG	Active
BRK	SK051	VAIK	K	HRD	DFG	Active
BRSK1	SK598	VAIK	K	HRD	DFG	Active
BRSK2	SK015	VAIK	K	HRD	DFG	Active
BTK	SK052	VAIK	K	HRD	DFG	Active
CaMK1a	SK056	VAIK	K	HRD	DFG	Active
CaMK1b	SK662	VALK	K	HRD	DFG	Active
CaMK1d	SK572	FAVK	K	HRD	DFG	Active
CaMK1g	SK021	FALK	K	HRD	DFG	Active
CaMK2a	SK057	YAAK	K	HRD	DFG	Active
CaMK2b	SK058	YAAK	K	HRD	DFG	Active
CaMK2d	SK703	YAAK	K	HRD	DFG	Active
CaMK2g	SK060	YAAK	K	HRD	DFG	Active
CaMK4	SK061	YALK	K	HRD	DFG	Active
CaMKK1	SK697	YAMK	K	HRD	DFG	Active
CaMKK2	SK482	YAMK	K	HRD	DFG	Active
caMLCK	SK536	LAAK	K	HLD	DFG	Active
CCRK	SK483	IALK	K	HRD	DFG	Active
CDC2	SK065	VAMK	K	HRD	DFG	Active
CDC7	SK066	IALK	K	HRD	DFG	Active
CDK10	SK294	VALK	K	HRD	DFG	Active
CDK11	SK443	YALK	K	HRD	DMG	Active
CDK2	SK067	VALK	K	HRD	DFG	Active
CDK3	SK068	VALK	K	HRD	DFG	Active
CDK4	SK069	VALK	K	HRD	DFG	Active
CDK5	SK070	VALK	K	HRD	DFG	Active
CDK6	SK071	VALK	K	HRD	DFG	Active
CDK7	SK055	VAIK	K	HRD	DFG	Active
CDK8	SK072	YALK	K	HRD	DMG	Active
CDK9	SK295	VALK	K	HRD	DFG	Active
CDKL1	SK203	VAIK	K	HRD	DFG	Active
CDKL2	SK202	VAIK	K	HRD	DFG	Active
CDKL3	SK509	VAIK	K	HRD	DFG	Active
CDKL4	SK466	VAVK	K	HRD	DFG	Active
CDKL5	SK361	VAIK	K	HRD	DFG	Active
CHED	SK076	VALK	K	HRD	DFG	Active
CHK1	SK078	VAVK	K	HRD	DFG	Active
CHK2	SK079	VAIK	K	HRD	DFG	Active
CK1a	SK082	VAVK	K	HRD	DFG	Active
CK1a2	SK541	VAVK	K	HRD	DFG	Active
CK1d	SK083	VAIK	K	HRD	DFG	Active
CK1e	SK084	VAIK	K	HRD	DFG	Active
CK1g1	SK647	VAIK	K	YRD	DFG	Active
CK1g2	SK086	VAIK	K	YRD	DFG	Active
CK1g3	SK087	VAIK	K	YRD	DFG	Active
CK2a1	SK088	VVVK	K	HRD	DWG	Active
CK2a2	SK089	VVVK	K	HRD	DWG	Active
CLIK1	SK493	VAVK	K	HRD	DFG	Active
CLIK1L	SK452	VAVK	K	HRD	DFG	Active
CLK1	SK090	VAVK	K	HTD	DFG	Active
CLK2	SK091	VALK	K	HTD	DFG	Active
CLK3	SK092	VALK	K	HTD	DFG	Active
CLK4	SK484	VAVK	K	HTD	DFG	Active
COT	SK093	MACK	K	HHD	DFG	Active
CRIK	SK695	YAMK	K	HRD	DFG	Active
CRK7	SK485	VALK	K	HRD	DFG	Active
CSK	SK095	VAVK	K	HRD	DFG	Active
CTK	SK418	VAVK	K	HRD	DFG	Active
DAPK1	SK103	YAAK	K	HFD	DFG	Active
DAPK2	SK104	YAAK	K	HFD	DFG	Active
DAPK3	SK716	YAAK	K	HFD	DFG	Active
DCAMKL1	SK063	YALK	K	HRD	DFG	Active
DCAMKL2	SK527	FALK	K	HRD	DFG	Active
DCAMKL3	SK459	YAMK	K	HRD	DFG	Active		
DDR1	SK400	VAVK	K	HRD	DFG	Active		
DDR2	SK410	VAVK	K	HRD	DFG	Active		
DLK	SK110	VAVK	K	HRD	DFG	Active		
DMPK1	SK111	YAMK	K	HRD	DFG	Active		
DMPK2	SK112	FAMK	K	HRD	DFG	Active		
DNAPK	SK113	FLVK	K	IGDRH	DFG	Active		HRD motif modified in PIKKs
Domain2_MSK1	zSK242b	FAVK	K	HRD	DFG	Active		Second kinase domain
Domain2_MSK2	zSK243b	FAVK	K	HRD	DFG	Active		Second kinase domain
Domain2_Obscn	zSK601b	LAAK	K	HLD	DLG	Active		Second kinase domain
Domain2_RSK1	zSK336b	YAVK	K	HRD	DFG	Active		Second kinase domain
Domain2_RSK2	zSK337b	FAVK	K	HRD	DFG	Active		Second kinase domain
Domain2_RSK3	zSK338b	YAVK	K	HRD	DFG	Active		Second kinase domain
Domain2_RSK4	zSK518b	FAVK	K	HRD	DFG	Active		Second kinase domain
Domain2_SPEG	zSK537b	FVAK	K	HLD	DFG	Active		Second kinase domain
DRAK1	SK486	FAAK	K	HLD	DFG	Active		
DRAK2	SK487	YAAK	K	HLD	DFG	Active
DYRK1A	SK234	VAIK	K	HCD	DFG	Active
DYRK1B	SK114	VAIK	K	HCD	DFG	Active
DYRK2	SK115	VALK	K	HCD	DFG	Active
DYRK3	SK488	VALK	K	HCD	DFG	Active
DYRK4	SK116	VALK	K	HCD	DFG	Active
EGFR	SK118	VAIK	K	HRD	DFG	Active
EphA1	SK121	VAIK	K	HRD	DFG	Active
EphA2	SK122	VAIK	K	HRD	DFG	Active
EphA3	SK123	VAIK	K	HRD	DFG	Active
EphA4	SK124	VAIK	K	HRD	DFG	Active
EphA5	SK125	VAIK	K	HRD	DFG	Active
EphA6	SK646	VAIK	K	HRD	DFG	Active
EphA7	SK416	VAIK	K	HRD	DFG	Active
EphA8	SK126	VAIK	K	HRD	DFG	Active
EphB1	SK127	VAIK	K	HRD	DFG	Active
EphB2	SK128	VAIK	K	HRD	DFG	Active
EphB3	SK129	VAIK	K	HRD	DFG	Active
EphB4	SK130	VAIK	K	HRD	DFG	Active
Erk1	SK134	VAIK	K	HRD	DFG	Active
Erk2	SK135	VAIK	K	HRD	DFG	Active
Erk3	SK136	VAIK	K	HRD	DFG	Active
Erk4	SK137	VAVK	K	HRD	DFG	Active
Erk5	SK408	VAIK	K	HRD	DFG	Active
Erk7	SK465	VAIK	K	HRD	DFG	Active
FAK	SK138	VAIK	K	HRD	DFG	Active
FER	SK140	VAVK	K	HRD	DFG	Active
FES	SK142	VAVK	K	HRD	DFG	Active
FGFR1	SK143	VAVK	K	HRD	DFG	Active
FGFR2	SK144	VAVK	K	HRD	DFG	Active
FGFR3	SK145	VAVK	K	HRD	DFG	Active
FGFR4	SK147	VAVK	K	HRD	DFG	Active
FGR	SK148	VAVK	K	HRD	DFG	Active		
FLT1	SK150	VAVK	K	HRD	DFG	Active		
FLT3	SK149	VAVK	K	HRD	DFG	Active		
FLT4	SK151	VAVK	K	HRD	DFG	Active		
FMS	SK094	VAVK	K	HRD	DFG	Active		
FRAP	SK152	FLLK	K	LGDRH	DFG	Active		HRD motif modified in PIKKs
FRK	SK419	VAVK	K	HRD	DFG	Active		
Fused	SK199	VALK	K	HRD	DFG	Active		
FYN	SK153	VAIK	K	HRD	DFG	Active		
GAK	SK155	YALK	K	HRD	DFG	Active		
GCK	SK048	AAVK	K	HRD	DFG	Active		
GCN2	SK490	YAVK	K	HRD	DFG	Active		
GPRK4	SK156	YACK	K	YRD	DLG	Active		
GPRK5	SK157	YACK	K	YRD	DLG	Active		
GPRK6	SK158	YACK	K	YRD	DLG	Active		
GPRK7	SK578	YACK	K	YRD	DLG	Active		
GSK3A	SK162	VAIK	K	HRD	DFG	Active
GSK3B	SK163	VAIK	K	HRD	DFG	Active
HCK	SK164	VAVK	K	HRD	DFG	Active
HER2/ErbB2	SK166	VAIK	K	HRD	DFG	Active
HER4/ErbB4	SK168	VAIK	K	HRD	DFG	Active
HH498	SK494	VAIK	K	HRD	DFG	Active
HIPK1	SK169	VAIK	K	HAD	DFG	Active
HIPK2	SK495	VAIK	K	HAD	DFG	Active
HIPK3	SK314	VAIK	K	HAD	DFG	Active
HIPK4	SK582	VAIK	K	HAD	DFG	Active
HPK1	SK170	VALK	K	HRD	DFG	Active
HRI	SK496	VCMK	K	HRD	DFG	Active
HUNK	SK502	VAIK	K	HRD	DFG	Active
ICK	SK497	IAIK	K	HRD	DFG	Active
IGF1R	SK174	VAIK	K	HRD	DFG	Active
IKKa	SK175	IAIK	K	HRD	DLG	Active
IKKb	SK176	IAIK	K	HRD	DLG	Active
IKKe	SK193	VAVK	K	HRD	DFG	Active
INSR	SK178	VAVK	K	HRD	DFG	Active
IRAK1	SK179	YAVK	K	HGD	DFG	Active
IRAK4	SK257	VAVK	K	HRD	DFG	Active
IRE1	SK182	VAVK	K	HRD	DFG	Active
IRE2	SK498	VAVK	K	HRD	DFG	Active
IRR	SK183	VALK	K	HRD	DFG	Active
ITK	SK184	VAIK	K	HRD	DFG	Active
JAK1	SK185	VAVK	K	HRD	DFG	Active
JAK2	SK186	VAVK	K	HRD	DFG	Active
JAK3	SK187	VAVK	K	HRD	DFG	Active
JNK1	SK188	VAIK	K	HRD	DFG	Active
JNK2	SK189	VAVK	K	HRD	DFG	Active
JNK3	SK190	VAIK	K	HRD	DFG	Active
KDR	SK402	VAVK	K	HRD	DFG	Active
KHS1	SK191	AAVK	K	HRD	DFG	Active
KHS2	SK427	AAIK	K	HRD	DFG	Active
KIS	SK661	GALK	K	HAD	DFG	Active
KIT	SK201	VAVK	K	HRD	DFG	Active
LATS1	SK441	YATK	K	HRD	DFG	Active
LATS2	SK442	YAMK	K	HRD	DFG	Active
LCK	SK206	VAVK	K	HRD	DFG	Active
LIMK1	SK412	MVMK	K	HRD	DFG	Active
LIMK2	SK207	MVMK	K	HRD	DFG	Active
LKB1	SK208	RAVK	K	HKD	DLG	Active
LMR1	SK413	VVVK	K	HSD	DYG	Active
LMR2	SK414	VIVK	K	HSD	DYG	Active
LMR3	SK415	VVVK	K	HSD	DYG	Active
LOK	SK426	AAAK	K	HRD	DFG	Active
LRRK1	SK698	FHIK	K	FCD	DYG	Active
LRRK2	SK690	VAVK	K	YRD	DYG	Active
LTK	SK209	VAIK	K	HRD	DFG	Active
LYN	SK210	VAVK	K	HRD	DFG	Active
LZK	SK398	VAVK	K	HRD	DFG	Active
MAK	SK211	VAIK	K	HRD	DFG	Active
MAP2K1	SK217	MARK	K	HRD	DFG	Active
MAP2K2	SK218	MARK	K	HRD	DFG	Active
MAP2K3	SK238	MAVK	K	HRD	DFG	Active
MAP2K4	SK239	MAVK	K	HRD	DFG	Active
MAP2K5	SK219	LAVK	K	HRD	DFG	Active
MAP2K6	SK220	MAVK	K	HRD	DFG	Active
MAP2K7	SK230	IAVK	K	HRD	DFG	Active
MAP3K1	SK221	MAVK	K	HRD	DFG	Active
MAP3K2	SK222	LAVK	K	HRD	DFG	Active
MAP3K3	SK223	LASK	K	HRD	DFG	Active
MAP3K4	SK224	MAMK	K	HRD	DFG	Active
MAP3K5	SK225	IAIK	K	HRD	DFG	Active
MAP3K6	SK503	IAIK	K	HRD	DFG	Active
MAP3K7	SK681	IAIK	K	HRD	DFG	Active
MAP3K8	SK573	IAVK	K	HRD	DFG	Active
MAPKAPK2	SK212	FALK	K	HRD	DFG	Active
MAPKAPK3	SK213	CALK	K	HRD	DFG	Active
MAPKAPK5	SK214	FALK	K	HRD	DFG	Active
MARK1	SK215	VAVK	K	HRD	DFG	Active
MARK2	SK120	VAVK	K	HRD	DFG	Active
MARK3	SK096	VAIK	K	HRD	DFG	Active
MARK4	SK515	VAIK	K	HRD	DFG	Active
MAST1	SK345	FAMK	K	HRD	DFG	Active
MAST2	SK216	FAMK	K	HRD	DFG	Active
MAST3	SK196	FAIK	K	HRD	DFG	Active
MAST4	SK701	FAMK	K	HRD	DFG	Active
MASTL	SK455	YAVK	K	HRD	DFG	Active
MELK	SK298	VAIK	K	HRD	DFG	Active
MER	SK226	VAVK	K	HRD	DFG	Active
MET	SK227	CAVK	K	HRD	DFG	Active
MISR2	SK228	VAIK	K	HRD	DLG	Active
MLK1	SK232	VAVK	K	HRD	DFG	Active
MLK2	SK233	VAVK	K	HRD	DFG	Active
MLK3	SK356	VAVK	K	HRD	DFG	Active
MLK4	SK691	VAVK	K	HRD	DFG	Active
MNK1	SK235	YAVK	K	HRD	DFD	Active
MNK2	SK236	YAVK	K	HRD	DFD	Active
MOK	SK505	YACK	K	HRD	DFG	Active
MOS	SK237	VAIK	K	HLD	DFG	Active
MPSK1	SK506	YALK	K	HRD	DLG	Active
MRCKa	SK299	FAMK	K	HRD	DFG	Active
MRCKb	SK241	YAMK	K	HRD	DFG	Active
MSK1	SK242	YAMK	K	YRD	DFG	Active
MSK2	SK243	YAMK	K	YRD	DFG	Active
MSSK1	SK507	VALK	K	HTD	DLG	Active
MST1	SK244	VAIK	K	HRD	DFG	Active
MST2	SK245	VAIK	K	HRD	DFG	Active
MST3	SK246	VAIK	K	HRD	DFG	Active
MST4	SK431	VAIK	K	HRD	DFG	Active
MUSK	SK247	VAVK	K	HRD	DFG	Active
MYO3A	SK636	AAVK	K	HRD	DFG	Active
MYO3B	SK583	AAVK	K	HRD	DFG	Active
MYT1	SK248	YAVK	K	HLD	D--	Active
NDR1	SK249	YAMK	K	HRD	DFG	Active
NDR2	SK500	YAMK	K	HRD	DFG	Active
NEK1	SK250	YVIK	K	HRD	DFG	Active
NEK10	SK645	LAMK	K	HRD	DFG	Active
NEK11	SK574	KVLK	K	HRD	DFG	Active
NEK2	SK251	LVWK	K	HRD	DFG	Active
NEK3	SK252	FAMK	K	HRD	DFG	Active
NEK4	SK256	YVIK	K	HRD	DLG	Active
NEK5	SK558	CVIK	K	HRD	DFG	Active
NEK6	SK420	VALK	K	HRD	DLG	Active
NEK7	SK421	VALK	K	HRD	DLG	Active
NEK8	SK476	VIIK	K	HRD	DFG	Active
NEK9	SK470	VVWK	K	HRD	DYG	Active
NIK	SK253	CAVK	K	HGD	DFG	Active
NIM1	SK449	VAIK	K	HRD	DFG	Active
NLK	SK255	VALK	K	HRD	DFG	Active
NuaK1	SK195	VAIK	K	HRD	DFG	Active
NuaK2	SK472	VAIK	K	HRD	DFG	Active
Obscn	SK601	CAAK	K	HLD	DFG	Active
OSR1	SK428	VAIK	K	HRD	DFG	Active
p38a	SK264	VAVK	K	HRD	DFG	Active
p38b	SK342	VAVK	K	HRD	DFG	Active
p38d	SK344	VAIK	K	HRD	DFG	Active
p38g	SK343	VAIK	K	HRD	DFG	Active
p70S6K	SK265	FAMK	K	YRD	DFG	Active
p70S6Kb	SK266	YAMK	K	YRD	DFG	Active
PAK1	SK267	VAIK	K	HRD	DFG	Active
PAK2	SK268	VAIK	K	HRD	DFG	Active
PAK3	SK269	VAIK	K	HRD	DFG	Active
PAK4	SK430	VAVK	K	HRD	DFG	Active
PAK5	SK510	VAVK	K	HRD	DFG	Active
PAK6	SK429	VAVK	K	HRD	DFG	Active
PASK	SK499	VVVK	K	HRD	DFG	Active
PBK	SK529	WAVK	K	HGD	DVG	Active
PCTAIRE1	SK271	VALK	K	HRD	DFG	Active
PCTAIRE2	SK272	VALK	K	HRD	DFG	Active
PCTAIRE3	SK273	VALK	K	HRD	DFG	Active
PDGFRa	SK274	VAVK	K	HRD	DFG	Active
PDGFRb	SK275	VAVK	K	HRD	DFG	Active
PDK1	SK276	YAIK	K	HRD	DFG	Active
PEK	SK281	YAIK	K	HRD	DFG	Active
PFTAIRE1	SK282	VALK	K	HRD	DFG	Active
PFTAIRE2	SK462	VALK	K	HRD	DFG	Active
PHKg1	SK283	YAVK	K	HRD	DFG	Active
PHKg2	SK284	FAVK	K	HRD	DFG	Active
PIK3R4	SK262	VVVK	K	HGD	DFA	Active
PIM1	SK291	VAIK	K	HRD	DFG	Active
PIM2	SK292	VAIK	K	HRD	DFG	Active
PIM3	SK200	VAVK	K	HRD	DFG	Active
PITSLRE	SK297	VALK	K	HRD	DFG	Active
PKACa	SK300	YAMK	K	YRD	DFG	Active
PKACb	SK301	YAMK	K	YRD	DFG	Active
PKACg	SK302	YAMK	K	HRD	DFG	Active
PKCa	SK303	YAIK	K	YRD	DFG	Active
PKCb	SK304	YAVK	K	YRD	DFG	Active
PKCd	SK305	FAIK	K	YRD	DFG	Active
PKCe	SK306	YAVK	K	YRD	DFG	Active
PKCg	SK307	YAIK	K	YRD	DFG	Active
PKCh	SK270	YAVK	K	YRD	DFG	Active
PKCi	SK308	YAMK	K	YRD	DYG	Active
PKCt	SK310	FAIK	K	YRD	DFG	Active
PKCz	SK311	YAMK	K	YRD	DYG	Active
PKD1	SK309	VAIK	K	HCD	DFG	Active
PKD2	SK480	VAVK	K	HCD	DFG	Active
PKD3	SK489	VAIK	K	HCD	DFG	Active
PKG1	SK073	FAMK	K	YRD	DFG	Active
PKG2	SK075	FAMK	K	YRD	DFG	Active
PKN1	SK317	FAIK	K	YRD	DFG	Active
PKN2	SK318	FAIK	K	YRD	DFG	Active
PKN3	SK511	YAIK	K	YRD	DFG	Active
PKR	SK119	YVIK	K	HRD	DFG	Active
PLK1	SK315	FAGK	K	HRD	DFG	Active
PLK2	SK353	YAAK	K	HRD	DFG	Active
PLK3	SK316	YAVK	K	HRD	DFG	Active
PLK4	SK341	VAIK	K	HRD	DFG	Active
PRKX	SK313	FALK	K	YRD	DFG	Active
PRKY	SK320	FALK	K	YRD	DFG	Active
PRP4	SK321	VAVK	K	HAD	DFG	Active
PSKH1	SK322	YAIK	K	HRD	DFG	Active
PYK2	SK424	VAVK	K	HRD	DFG	Active
QIK	SK513	VAIK	K	HRD	DFG	Active
QSK	SK501	VAIK	K	HRD	DFG	Active
RAF1	SK324	VAVK	K	HRD	DFG	Active
RET	SK326	VAVK	K	HRD	DFG	Active
RHOK	SK327	YACK	K	YRD	DLG	Active
RIPK1	SK328	MIMK	K	HKD	DLG	Active
RIPK2	SK329	VAVK	K	HHD	DFG	Active
RIPK3	SK330	VAVK	K	HRD	DFG	Active		
ROCK1	SK331	YAMK	K	HRD	DFG	Active		
ROCK2	SK263	YAMK	K	HRD	DFG	Active		
RON	SK332	CAIK	K	HRD	DFG	Active		
ROR1	SK333	VAIK	K	HKD	DLG	Active		
ROR2	SK334	VAIK	K	HKD	DLG	Active		
ROS	SK335	VAVK	K	HRD	DFG	Active		
RSK1	SK336	YAMK	K	YRD	DFG	Active		
RSK2	SK337	YAMK	K	YRD	DFG	Active		
RSK3	SK338	YAMK	K	YRD	DFG	Active		
RSK4	SK518	YAMK	K	YRD	DFG	Active		
RYK	SK340	AFVK	K	HKD	DNA	Active		"Has failed experimentally to show catalytic activity. The unusual R-K change in HRD motif is also seen in three Drosophila homologs and may kill activity, or make it experimentally undetectable. However, a similar HKD motif is seen in several active kinases"
SBK	SK650	MALK	K	HRD	DFG	Active		
SGK	SK346	YAVK	K	YRD	DFG	Active		
SgK069	SK581	LALK	K	YRD	DFG	Active		
SgK085	SK709	LAAK	K	HLD	DFG	Active		
SGK2	SK523	YAVK	K	YRD	DFG	Active		
SgK288	SK658	YAIK	K	HLD	DFG	Active		
SGK3	SK525	YAVK	K	YRD	DFG	Active		
SgK494	SK491	FAVK	K	HRD	DFG	Active		
SgK496	SK516	CALK	K	HRD	DLG	Active		
SIK	SK604	VAIK	K	HRD	DFG	Active		
skMLCK	SK675	LAAK	K	HLD	DFG	Active		
SLK	SK348	AAAK	K	HRD	DFG	Active		
SMG1	SK665	YLFK	K	LGDRH	DYN	Active		HRD motif modified in PIKKs
smMLCK	SK231	WAGK	K	HLD	DFG	Active		
SNRK	SK625	VAVK	K	HRD	DFG	Active		
SPEG	SK537	FAAK	K	HLD	DFG	Active		
SRC	SK357	VAIK	K	HRD	DFG	Active		
SRM	SK425	VAIK	K	HRD	DFG	Active		
SRPK1	SK358	VAMK	K	HTD	DLG	Active		
SRPK2	SK359	VAMK	K	HTD	DLG	Active		
SSTK	SK524	VAIK	K	HRD	DFG	Active
STK33	SK463	WAIK	K	HRD	DFG	Active
STLK3	SK432	VAIK	K	HRD	DFG	Active
SYK	SK363	VAVK	K	HRD	DFG	Active
TAK1	SK364	VAIK	K	HRD	DFG	Active
TAO1	SK436	VAIK	K	HRD	DFG	Active
TAO2	SK362	VAIK	K	HRD	DFG	Active
TAO3	SK435	VAIK	K	HRD	DFG	Active
TBK1	SK531	FAIK	K	HRD	DFG	Active
TEC	SK366	VAIK	K	HRD	DFG	Active
TESK1	SK368	MVLK	K	HRD	DFG	Active
TESK2	SK532	MALK	K	HRD	DFG	Active
TGFBR1	SK029	VAVK	K	HRD	DLG	Active
TGFBR2	SK369	VAVK	K	HRD	DFG	Active
TIE1	SK370	AAIK	K	HRD	DFG	Active
TIE2	SK367	AAIK	K	HRD	DFG	Active
TLK1	SK373	AAVK	K	HYD	DFG	Active
TLK2	SK374	VAVK	K	HYD	DFG	Active
TNK1	SK375	VAVK	K	HRD	DFG	Active
Trad	SK533	VAVK	K	HLD	DLE	Active
Trio	SK376	VATK	K	HLD	DFG	Active
TRKA	SK377	VAVK	K	HRD	DFG	Active
TRKB	SK378	VAVK	K	HRD	DFG	Active
TRKC	SK379	VAVK	K	HRD	DFG	Active
TSSK1	SK705	VAIK	K	HRD	DFS	Active
TSSK2	SK474	VAVK	K	HRD	DFG	Active
TSSK3	SK471	VAIK	K	HRD	DFG	Active
TSSK4	SK534	VAVK	K	HRD	DFG	Active
TTBK1	SK526	VALK	K	HRD	DFG	Active
TTBK2	SK453	VALK	K	HRD	DFG	Active
TTK	SK383	YAIK	K	HSD	DFG	Active
TXK	SK384	VAIK	K	HRD	DFG	Active
TYK2	SK385	VAVK	K	HRD	DFG	Active
TYRO3	SK386	VAVK	K	HRD	DFG	Active
ULK1	SK387	VAVK	K	HRD	DFG	Active
ULK2	SK388	VAIK	K	HRD	DFG	Active
ULK3	SK450	VAIK	K	HLD	DFG	Active
Wee1	SK391	YAIK	K	HMD	D-E	Active
Wee1B	SK723	YAIK	K	HLD	DLG	Active
YANK1	SK624	YAMK	K	HRD	DFN	Active
YANK2	SK481	YAMK	K	HRD	DFN	Active
YANK3	SK469	YAMK	K	HRD	DFN	Active
YES	SK393	VAIK	K	HRD	DFG	Active
YSK1	SK395	VAIK	K	HRD	DFG	Active
ZAK	SK504	VAVK	K	HRD	DFG	Active
ZAP70	SK397	VAIK	K	HRD	DFG	Active
ZC1/HGK	SK437	AAIK	K	HRD	DFG	Active
ZC2/TNIK	SK438	AAIK	K	HRD	DFG	Active
ZC3/MINK	SK439	AAIK	K	HRD	DFG	Active			
ZC4/NRK	SK440	TAVK	K	HRD	DFG	Active			
IRAK3	SK181	YAVK	K	CGS	DFA	Active	2.00E-27		
SgK110	SK592	VALK	K	HAD	DLG	Active	9.00E-27		
PINK1	SK456	LAIK	K	HRD	DFG	Active	1.00E-20		
BUB1	SK409	FVLK	K	HGD	DLG	Active	4.00E-11		
VRK1	SK389	CVVK	K	HGD	DYG	Active	4.00E-10		
RNAseL	SK729	VAVK	K	HQD	DFD	Active	1.00E-09		
VRK2	SK390	CVVK	K	HGD	DYG	Active	3.00E-09		
SgK493	SK460	VALK	K	LLD	DLD	Active	6.00E-08		
BUBR1	SK053	TVIK	K	HGD	DFS	Active	0.003		
PRPK	SK464	PALE	E	HGD	DFG	Active - alternative K used	1.00E-05	"Missing the canonical K residue, but has a nearby K that is conserved in several orthologs."	Catalytic activity published
Wnk1	SK508	VAWC	C	HRD	DLG	Active - alternative K used		"All Wnk family kinases lack the canonical K but contain an upstream conserved K that for Wnk1 was shown to be required for catalytic activity (Xu et al, JBC (2000) 275:16795-801)"	
Wnk2	SK016	VAWC	C	HRD	DLG	Active - alternative K used		"All Wnk family kinases lack the canonical K but contain an upstream conserved K that for Wnk1 was shown to be required for catalytic activity (Xu et al, JBC (2000) 275:16795-801)"	
Wnk3	SK641	VAWC	C	HRD	DLG	Active - alternative K used		"All Wnk family kinases lack the canonical K but contain an upstream conserved K that for Wnk1 was shown to be required for catalytic activity (Xu et al, JBC (2000) 275:16795-801)"	
Wnk4	SK588	VAWC	C	HRD	DLG	Active - alternative K used		"All Wnk family kinases lack the canonical K but contain an upstream conserved K that for Wnk1 was shown to be required for catalytic activity (Xu et al, JBC (2000) 275:16795-801)"	
CASK	SK064	FAVK	K	HRD	GFG	Inactive - missing DFG	1.00E-74	"All family members (1 human, 1 fly, 1 worm) predicted to be inactive"
CCK4	SK411	VLVK	K	HKD	ALG	Inactive - missing DFG	3.00E-73	Experimentally fails to show catalytic activity; homologs in fly and hydra also predicted to be inactive
TTN	SK372	YMAK	K	HFD	EFG	Inactive - missing DFG	1.00E-60	
SuRTK106	SK530	VILK	K	HGD	 -LG	Inactive - missing DFG	1.00E-38	
SgK495	SK492	----	-	HRD	NFC	Inactive - missing DFG	6.00E-38	
Trb1	SK014	LRCK	K	LGD	SLE	Inactive - missing DFG	8.00E-36	"All members of this family (3 human, 1 fly) are predicted to be inactive)"
Trb2	SK160	LVCK	K	LRD	SLE	Inactive - missing DFG	7.00E-35	"All members of this family (3 human, 1 fly) are predicted to be inactive)"
Trb3	SK694	YTCK	K	LRD	NLE	Inactive - missing DFG	3.00E-23	"All members of this family (3 human, 1 fly) are predicted to be inactive)"
SgK269	SK649	YAVK	K	HCD	NFS	Inactive - missing DFG	8.00E-06	
SgK223	SK643	YAVK	K	HRD	NFL	Inactive - missing DFG	9.00E-06	
Haspin	SK692	VAIK	K	HRD	TLN	Inactive - missing DFG	0.002	"Missing C-term, but shown to have activity."
PSKH2	SK602	FAIK	K	HRN	DFG	Inactive - missing HRD	1.00E-76	
ILK	SK177	IVVK	K	RHA	---	Inactive - missing HRD	5.00E-64	"Experimentally shown to have catalytic activity, which is lost when catalytic K is mutated to E (Persad et al (2000) PNAS 97 (7) 3207-12). Orthologs in fly and worm are also missing catalytic residues."
HSER	SK171	VILK	K	HGR	DFG	Inactive - missing HRD	8.00E-56	"All RGC group kinase domains (5 human, 6 fly, 26 worm) are predicted to be inactive"
HER3/ErbB3	SK167	VCIK	K	HRN	DFG	Inactive - missing HRD	2.00E-50	Experimentally fails to show catalytic activity
ANPb	SK035	VAIK	K	HGS	DYG	Inactive - missing HRD	2.00E-41	"All RGC group kinase domains (5 human, 6 fly, 26 worm) are predicted to be inactive"
CYGF	SK099	VWLK	K	HGR	DYG	Inactive - missing HRD	5.00E-36	"All RGC group kinase domains (5 human, 6 fly, 26 worm) are predicted to be inactive"
ANPa	SK034	VAVK	K	HGN	DYG	Inactive - missing HRD	6.00E-33	"All RGC group kinase domains (5 human, 6 fly, 26 worm) are predicted to be inactive"
VACAMKL	SK062	HTCK	K	HRN	DFH	Inactive - missing HRD	4.00E-31	
Domain2_JAK1	zSK185b	VILK	K	HGN	DPG	Inactive - missing HRD	1.00E-26	"Second kinase domain; believed to have a regulatory role. All secondary domains of Jak family kinases (4 from human, 1 from fly) are predicted to be inactive"
CYGD	SK097	VWLK	K	HGR	DHG	Inactive - missing HRD	4.00E-26	"Aparcio and Applebury (JBC, 1996) do show kinase activity in crude extracts, maybe artefactual. All RGC group kinase domains (5 human, 6 fly, 26 worm) are predicted to be inactive"
SgK071	SK521	KQVE	E	HRN	DLS	Inactive - missing HRD	9.00E-25	
Domain2_JAK2	zSK186b	VLLK	K	HGN	DPG	Inactive - missing HRD	1.00E-24	"Second kinase domain; believed to have a regulatory role. All secondary domains of Jak family kinases (4 from human, 1 from fly) are predicted to be inactive"
Domain2_TYK2	zSK385b	VVLK	K	HGN	DPG	Inactive - missing HRD	6.00E-23	"Second kinase domain; believed to have a regulatory role. All secondary domains of Jak family kinases (4 from human, 1 from fly) are predicted to be inactive"
Domain2_JAK3	zSK187b	VLLK	K	HGN	DPG	Inactive - missing HRD	1.00E-07	"Second kinase domain; believed to have a regulatory role. All secondary domains of Jak family kinases (4 from human, 1 from fly) are predicted to be inactive"
SgK396	SK652	ILLK	K	HGS	DFD	Inactive - missing HRD	9.00E-05	"All RGC group kinase domains (5 human, 6 fly, 26 worm) are predicted to be inactive"
STLK6	SK434	VTIK	K	HRS	GLS	"Inactive - missing HRD, DFG"	4.00E-36	"Both human family members are predicted to be inactive, as are 1 worm and 1 fly homolog. Another worm homolog has HRD and DFG motifs, but the predicions lacks the N-terminal end of the kinase domain"
MLKL	SK458	KVFK	K	HGK	ELR	"Inactive - missing HRD, DFG"	2.00E-29	
IRAK2	SK180	FVFK	K	HSN	HP-	"Inactive - missing HRD, DFG"	2.00E-22	
SgK307	SK699	VTVK	K	HRS	NLE	"Inactive - missing HRD, DFG"	0.001	
KSR2	SK605	VAIR	R	HKD	LFS	Inactive - missing K	5.00E-60	
KSR1	SK205	VAIR	R	HKD	LFG	Inactive - missing K	7.00E-55	
ULK4	SK457	VAIL	L	FCD	NFC	"Inactive - missing K, DFG"	2.00E-35	
RSKL1	SK517	LKTE	E	CRD	YFS	"Inactive - missing K, DFG"	3.00E-25	"All family members (2 human, 1 fly, 1 worm) are predicted to be inactive. "
RSKL2	SK473	LHLE	E	CRD	YFG	"Inactive - missing K, DFG"	1.00E-18	"All family members (2 human, 1 fly, 1 worm) are predicted to be inactive. "
Domain2_GCN2	zSK490b	WVLQ	Q	HKV	DYS	"Inactive - missing K, HRD"	9.00E-21	"Second kinase domain. All GCN2 family kinases (1 human, 1 fly , 1 worm, 1 yeast) have a domain which is predicted to be inactive."
STLK5	SK433	VTVR	R	HRS	GLR	"Inactive - missing K, HRD, DFG"	3.00E-40	"Both human family members are predicted to be inactive, as are 1 worm and 1 fly homolog. Another worm homolog has HRD and DFG motifs, but the predicions lacks the N-terminal end of the kinase domain"
TBCK	SK664	LTPN	N	HRA	KFG	"Inactive - missing K, HRD, DFG"	5.00E-38	
EphA10	SK627	VAVH	H	HRG	GFG	"Inactive - missing K, HRD, DFG"	2.00E-37	
EphB6	SK132	VAIQ	Q	HRS	RLG	"Inactive - missing K, HRD, DFG"	5.00E-36	
NRBP1	SK479	VVWN	N	HGN	VAP	"Inactive - missing K, HRD, DFG"	1.00E-18	"All family members (2 human, 1 fly, 1 worm) are predicted to be in active. "
NRBP2	SK520	VVWN	N	HGN	ALP	"Inactive - missing K, HRD, DFG"	2.00E-14	"All family members (2 human, 1 fly, 1 worm) are predicted to be in active. "
SCYL2	SK475	VAVF	F	HGN	GFD	"Inactive - missing K, HRD, DFG"	2.00E-14	"All members of this family (3 human, 4 fly, 2 worm, 1 yeast) are predicted to be inactive"
Slob	SK528	LVLS	S	YGH	DLE	"Inactive - missing K, HRD, DFG"	3.00E-05	
SgK196	SK628	VALS	S	TRV	NFS	"Inactive - missing K, HRD, DFG"	0.0004	Very divergent kinase-like domain
SCYL3	SK468	ASVF	F	HNN	GME	"Inactive - missing K, HRD, DFG"	0.002	"All members of this family (3 human, 4 fly, 2 worm, 1 yeast) are predicted to be inactive"
VRK3	SK535	----	-	HGN	GYG	"Inactive - missing K, HRD, DFG"	0.01	
SCYL1	SK454	VSIF	F	HNN	GLD	"Inactive - missing K, HRD, DFG"	0.02	"All members of this family (3 human, 4 fly, 2 worm, 1 yeast) are predicted to be inactive"
SgK424	SK707	----	-	---	---	"Inactive - missing K, HRD, DFG"	0.33	"Very poor kinase domain homology, but is a clear homolog of SGK307, which has a divergent kinase domain"
TRRAP	SK380	YLVM	M	LNRLN	YFR	"Inactive - missing K, HRD, DFG"	(atypical)	"HRD motif modified in PIKKs. All family members (1 human, 1 fly, 1 worm, 1 yeast) are predicted to be inactive"