>YtaA_pdb_2Q83
-------------GEEGNSSELPLSAEDAKKLTELAENVLQGW-DVQ-AEKIDVIQGN---QMALVWKVHTD
------------------------------SGAVCLKRIHRPE--KKALFSIFAQDYLAK-KGMNVPGILPN
KKGS-----LYSKHGSFLFVVYDWIE--GRPFELTVKQDLEFIMKGLADFHTASVGYQ--------------
-----------------------------------------PPNGVPIFTKLGRWPNHYTKRCKQMETWKLM
AEAEK-ED-PFSQLYLQEIDGFIEDGLRIKDRLLQS------------------------------------
TYVPWTEQLKKSPNLCHQDYGTGNTLLGEN----------------------------------EQIWVIDL
DTVSFDLPIRDLRKMIIP-LLDT--TGVWDDETFNVMLNAYESRAPLTEEQKQVMFIDMLF--PYELYDVIR
-EKYVRKSA---LPKEE-LESAFEYERIKANAL---RQLI--------------------------------
---
>YtaA_B.subtilis
--MCPLMAENHEVIEEGNSSELPLSAEDAKKLTELAENVLQGW-DVQ-AEKIDVIQGN---QMALVWKVHTD
------------------------------SGAVCLKRIHRPE--KKALFSIFAQDYLAK-KGMNVPGILPN
KKGS-----LYSKHGSFLFVVYDWIE--GRPFELTVKQDLEFIMKGLADFHTASVGYQ--------------
-----------------------------------------PPNGVPIFTKLGRWPNHYTKRCKQMETWKLM
AEAEK-ED-PFSQLYLQEIDGFIEDGLRIKDRLLQS------------------------------------
TYVPWTEQLKKSPNLCHQDYGTGNTLLGEN----------------------------------EQIWVIDL
DTVSFDLPIRDLRKMIIP-LLDT--TGVWDDETFNVMLNAYESRAPLTEEQKQVMFIDMLF--PYELYDVIR
-EKYVRKSA---LPKEE-LESAFEYERIKANAL---RQLI--------------------------------
---
>YtaA_Anoxybacillus_flavithermu
----MSNRRGYMLIEPWIVDETMHEFFVPDYIEQMAEDVLRHY-DLS-VQSRQVVTTKPDKG-GAIWKLETN
------------------------------KGPKSLKLLHRRP--TRSLFSLGAQRYLVDVQKANVPPIVQT
TDGM-----DYVEGGGKLWFVAEWIEP-LFPVTKD-LEGAKQLCYALGEFHRLSKGYV--------------
-----------------------------------------PPKGAEIASRLYKWPKTYEKTINKMDWFRQL
AKAYR-EM-PASAMLLEVVDHFQAQARESFARLQQS------------------------------------
SYHQLVERGNSEWGLVHQDYGWSNGQMGAN----------------------------------G-MWIIDL
DGVAYDLPIRDLRKLISG-TMAD--LYRWDVHWVREMIRAYHEANPIDASLYDVLMIDLSL--PNEFYKNLK
-EVVYDPEL---FLNEQ-TMQLIETIVATDATK---WPVLAEIENDWKENGNR-------------------
---
>YtaA_B.cereus_AH1134
TVIREHKRMVIYVENNNEEAVYTLSPEEEQKLVELAATMIQHW-DIQ-ATTIELIQGG---QLALVWKIQTA
------------------------------DGPFCLKRIHRPE--KKALFSIHAQDYLAN-KGMRVPSIIPS
KLNQ-----LYTKHGPFLFVVYDWIE--GRPFELTMQEDLEMIMKGLADFHVASIGYK--------------
-----------------------------------------PPPGIPIFTKLGRWPNHYIKRFQQMEIWKTL
SATMP-DD-PFSQLYLAEIDTFILEAKQTHQRLLES------------------------------------
EYTKWTDELQTSPNLCHQDYGTGNSLLDPS----------------------------------NQIWVIDL
DTVSYDLPIRDLRKMIIP-LLDT--TGVWNENQFKIMINAYESVSPLTAEQKKIMFIDMLF--PYELYDVIR
-ERYVRKSP---LLADE-LAGAMEYEKIKSKAL---NILIEEL-----------------------------
---
>YtaA_B.cereus_cytotoxis
------------MENYNQEEGDTLSPEEEQKLVALAETMIKHW-DID-PTTIELIQGG---QLALVWKIHTS
------------------------------NGAFCLKRIHRPE--KKALFSIHAQDYLAK-KGMHVPSIIPN
KKNQ-----LYTKHSPFLFVVYDWIE--GRPFELTMKEDLEMIMKGLADFHLASIGYK--------------
-----------------------------------------PPPGVPIFTKLGRWPNHYIKRFQQMEIWKNL
SATLI-DD-PFSQMYLEEITPFITEAKHTYQRLLES------------------------------------
EYGQWTEQLQSAPNLCHQDYGTGNSLLAPN----------------------------------NQIWVIDL
DTVSYDLPIRDLRKMIIP-LLDT--TGVWNEDQFHIMINAYESVSPLTAEQKKIMFIDMLF--PYELYDVIR
-EKYVRKTP---LLAEE-LAGAMEYERIKSKAL---NILLKDF-----------------------------
---
>YtaA_B.halodurans
-----MEQERPQIITPWDLDGTLGENYVPDYIHEMAQDVLTHY-EFQ-ANGLEVITTKADKG-GLIWKMETD
------------------------------QGPKSLKILHRRP--SRSWFSLGAQEYLVKEKQARVPEIIRT
KTGE-----LAVEKGEKLWFVAEWIEP-LFQVTKD-LEGAKQLCHAIGEFHQLSKGYV--------------
-----------------------------------------PPDRAETASRIYRWPKTYQKIVKKMTWFKNI
ANLYP-EL-AASQLILQVIDRFEAQAIDALQRLEQS------------------------------------
SYHEMSAKGNEAWGLAHQDYGWSNGQMGPN----------------------------------G-MWIIDL
DGVAYDLPIRDLQKLITG-NDG--------------------------------------------------
------------------------------------------------------------------------
---
>YtaA_B.sp_14911
--------MERIEIVPWEVTDSMHEFFVPEYINELAAEVLKSY-DLS-VQSITVVTTKPDKG-GAIWKLETG
------------------------------SGPKSLKLLHRRP--TRSLFSLGAQEYLVDVQDARVPPIYKT
KEGH-----NYVEAGGKLWFAAEWIEP-LAPVTKD-LEGARQLCYALGEFHRLSKGYT--------------
-----------------------------------------PPPSAEIASRVLKWPKSYQKVLNKMDWLRNI
AAAYK-EM-PASESLKNAVGHFEEQAKQGIEKLKSS------------------------------------
AYGDLAAHGNEFWGLVHQDYGWSNGQMGSG----------------------------------G-MWIIDL
DGVAYDLPIRDLRKLITG-SMAD--LYRWDITWVREMIKAYHEAYPISPELYDLLLIDLSM--PNEFYKNLK
-EAVYEPEL---FLNEQ-TTQLIQTILDTDQTK---WPVLEEIQNDWKGAQSL-------------------
---
>YtaA_B.weihen
TVIREYKRMVVYVENHNEEAVYTLSPEEEQKLVALAETMIQHW-DIQ-ATTIELIQGG---QLALVWKIHTT
------------------------------DGPFCLKRIHRPE--KKALFSIHAQDYLAK-KGMRVPSIIPS
KVNQ-----LYTKHGPFLFVVYEWIE--GRPFELTMQEDLEMIMKGLADFHVASIGYK--------------
-----------------------------------------PPPGIPIFTKLGRWPNHYIKRFQQMEIWKNL
SATMP-DD-PFSQLYLAEIDAFILEAKHTHQRLLES------------------------------------
EYTKWTDELQTFPNLCHQDYGTGNSLLDPS----------------------------------NQIWVIDL
DTVSYDLPIRDLRKMIIP-LLDT--TGVWNADQFQIMINAYESVSPLTAEQKKIMFIDMLF--PYELYDVIR
-EKYVRKSP---LLANE-LAEAMEYERIKSKAL---NILIEEF-----------------------------
---
>YtaA_C.thermocellum_ATCC_27405
--------------------MNEVGKNPNMDLSKLASSVLEEY-GIE-PENISVVQSAN---IKTVWRIKTK
------------------------------DRELCLKRLKHPL--DKALFSVNAQDFIYNHGGN-VAGIIRD
KEGN-----LIHSFNDQLFVVYEWLYG--RDLSFVNADDLKSALHGLAKFHIASKGYV--------------
-----------------------------------------APEGAKVSSKLGRWPEQYKSMADKLSSWKEA
SLGKP-AS-ASVNAYLKNVDEMLDICHRAMELLNAS------------------------------------
KYAELAGENSKSAVLCHQDYGKGNALFTD-----------------------------------NGVYVIDL
DGVTWDHPGRDLRKIIGK-LSEN--RGAWSLDQIEKILDWYSEINPLSTADRELIYIDLMY--PHWFFGLVK
-NIFKNNKS---ESPSK-IEKTARLETSKVPLL---AEKLRDIKSQG-------------------------
---
>YtaA_Geobacillus.kaustophilus
--------MKDIVIEPWLVDETTHEFFIPEYIIQLAEEVLKNY-DLS-VQNMQIVTTKPDKG-GAIWKLETK
------------------------------SGPKSLKLLHRRP--TRSLFSLGAQEYLVEVRKARVPPIVKT
KDEK-----SYVEAGGKLWFVAEWIEP-LTPVTKD-LEGARKLCYALGEFHRLSKGYV--------------
-----------------------------------------PPKQAEMASRLHKWPKNYEKMITKMSWFRNI
AKYYP-EM-PASPPLLEVVDRFEEQARKGMERFLQS------------------------------------
SYVEFVKQGTAHWGLVHQDYGWSNGQMGAD----------------------------------G-MWIIDL
DGVAFDLPIRDLRKLISG-TMAD--LYKWDATWVREMILAYHEANPITPELYELLMIDLAM--PNEFYKNMK
-EVVYEPEI---FLNEQ-TAQLIQTIVETDQSK---WPVLAEIENDWKGVG---------------------
---
>YtaA_Geobacillus.thermodenitri
-------------MMADQTVYSTTSPVTNERLVHMARLLLKQW-DVE-AKAIEVIQSG---QMALVWKVYTD
------------------------------DGPKCLKRIHRPK--KKALFSIYAQDTLAK-KGLYVPRIIET
RNHR-----LFKQYGPFLFVLYDWIE--GTPFDLNVHDDLIAMIEALAHFHEQSVGYE--------------
-----------------------------------------PPPGVPVFSKLGKWPKHYMKRCRQLEAWKQL
AKLDR-DD-PFSRLYLAEIDRFIEKGEEVLQQLLES------------------------------------
YYETWVEQMKKRPSLCHQDYGTGNSLRGED----------------------------------GNVWIIDL
DTTAFDLPIRDVRKMMAP-FLFE--TDEKGKTKADIVLEAYEDVRPLTKKEKKVLFIDLLF--PYDLHELAV
-EKYIRNVP---ITEAE-LAEAMAYEQAKWEEI---ERRLDSL-----------------------------
---
>YtaA_Symbiobacterium.thermophi
KADRRGAQVSAVAPARRNQEEALPDLTVPPEIQDLAERAAKAW-DMK-VGSWTVAATKPEKGWGAIWRIETN
------------------------------RGPRALKLLHRPF--ERNLFSIGAQDYLVR-RKARVAPLVPT
RDGK-----LYTVVDGRMFIVAEWIQG-LRQAPKDTVDGAALLCSGLAEFHRRSLGYR--------------
-----------------------------------------PPSGAAPSSRLHRWPRVYRKLRTKLDWFEHL
ARAYR-EM-PASPLLLEVLPRFKAQADEAIRMLEAS------------------------------------
AYRKLAARGEEAWGLAHQDYGWSNGQVGPD----------------------------------GKVWIIDL
DGVAFDLAFRDLRKLITG-TMDD--RGDWDLTWMKAMIRAYHEVHPIEPEAMQVMLIDMYL--PNEFYKLVK
-DVLYDPN----LLDAT-MVQALQRLLITDEHK---QQALRELGLRRRG-----------------------
---
>YtaA_Brevibacillus.brevis
--MEQYVIKPWDTREGNVETPANWDLTVPPEVDAIAEQVIKEY-DMSVKSRTLITSKPDK--GGAIWRIETD
------------------------------KGPRSLKVLHRTP--ERSLYSVAFQEYVVK-QGARVPALIPA
RNGS-----LYVEKGGKLWIVTDWIAL--QPATKVDLVGAQELCYGLGEFHRHSKGYV--------------
-----------------------------------------PPAGAKNSSRLYRWPNHYQKIAKKIGWMREI
AKAYSETP--TSKSILAVVDHYEQRAWAALEKLKAS------------------------------------
AYPKMIKMGEAHWGLVHQDYGWSNGQNGP-----------------------------------GGLWVIDL
DGVSYDLPFRDLRKLITSTMDDM---GVWDVTWMRGMIEAYHKANPLDRESFEVLLNDMAV--PNEFYKHLK
-EMFYDPATFLSTEAEGILQRVLTGDQTKDAALAELAKDISKYEPGNYDQITEVVEPQRLASGIKELLPVGL
STP
>YtaA_Desulfotomaculum.acetoxidans
---------------------------MQENLLEIAKQVILDY-DIKPSVVELFQYGSIK----TVWKLYDS
------------------------------SGLYCLKRMRYDI--EKCLFSVNAQKYMLE-KGANLPDIVDN
IHGS-----SCTKYKGQTFVLYKWLAG--RQLKFEKKRDLKLLVKGLARFHLASAGYT--------------
-----------------------------------------AGSEILISSKLGRWPHQYSSMRDRLIRWKET
ARGKSRNK--LGRIYLEQADFFISLADKALELLEKS------------------------------------
GYSQWVNELQLRKTLCHQDYGESNTLWTG-----------------------------------KQLVVLDL
DGVAYDLPVRDLRKLIFKVMLLR---KGWHEDTWRKILTWYEAENPFTEEQRRILLIDLLF--PHEFHNTAK
-NPFHKGKES--------SANKLALVSSWEQQK---AAFLKKLL----------------------------
---
>CotS_B.subtilis
-------------------------MYQKEHEEQIVSEILSYY-PFH-IDHVALKSNK---SGRKIWEVETD
------------------------------HGPKLLKEAQMKP--ERMLFITQAHAHLQE-KGLPIAPIHQT
KNGG-----SCLGTDQVSYSLYDKVT--GKEMIYYDAEQMKKVMSFAGHFHHASKGYV--------------
-----------------------------------------CTDESKKRSRLGKWHKLYRWKLQELEGNMQI
AASYP-DD-VFSQTFLKHADKMLARGKEALRALDDS------------------------------------
EYETWTKETLEHGGFCFQDFTLARLTEIE-----------------------------------GEPFLKEL
HSITYDLPSRDLRILLNK-VMVK--LSVWDTDFMVALLAAYDAVYPLTEKQYEVLWIDLAF--PHLFCAIGH
-KYYLKQKK---TWSDEKYNWALQNMISVEESK---DSFLDKLPELYKKIKAYREAN---------------
---
>CotS_B.cereus_AH1134
------------------------MEETTGLESEHLKKVLSFY-PFE-ISNIFLQSSR---SGRTMWEVETE
------------------------------EGLKILKQAQMHP--KRMLFIAGAHLHLLQ-NGLPITKIHKT
KRGG-----FCIGSNEYAYVLYDKHQ--GKEVIYYNKEQLEKVLIYAGKFHQASEGYI--------------
-----------------------------------------PMKESKIRSRLGKWHKLYRWKLQELEGNKRI
ALSFP-DD-VFSTMFLEYVDKMLARGKKALQELNDP------------------------------------
YYDQWTKEVIASNSFCQQDFTLARFTEID-----------------------------------DAMFMKEL
HSITSDLPVRDLRIILNK-VMKK--MSVWDTNLAIHMLSAYNSENSFSEKQFRVLWTDLSF--PHLFCSIAH
-KYYLGQKR---SWSDEKYIWALQNIIALEDSK---EEFLRNFSDIYHEIKSNSGGK---------------
---
>CotS_B.cereus_cytotoxis
-----------------------MLEETPALEREHLNKVLGFY-PFE-INNITLQSSR---SGRTIWEVETE
------------------------------EGVKILKQAQMKP--ERMLFIAGAHLHLLQ-NGLPITQIHKT
KRGG-----FCIGSGEYAYVLYDKYQ--GKEVIYYNKEQLEKVLIYAGKFHKASEGYI--------------
-----------------------------------------PQIESKTRSRLGKWHKLYRWKLQELEGNKRI
AQSFP-ND-MFSTMFLEYVDKMLVRGKRALQEIDDP------------------------------------
FYNQWTKEIITNKSFCQQDFTLARFTEID-----------------------------------NAIFMKEL
HSITHDLPVRDLRIILNK-VMKK--MATWDIDLAIHMLSAYDLENSLSEKQFRILWTDLSF--PHLFCSIAH
-KYYLKQKR---SWSDEKYIWALQNVIALEDSK---EEFLQQFSDIYREIKSRNGGEIK-------------
---
>CotS_B.weihen
------------------------MEETTGLESEHLKKVLSFY-PFE-VSNIILQSSR---SGRTIWEVETE
------------------------------EGLKILKQAHMHP--KRMLFIAGAHLHLLQ-NGLPITKIHNT
KRGG-----FCIGSGEYAYVLYDKHQ--GKEVIYYNKEQLEKVLIYAGKFHQASEGYI--------------
-----------------------------------------PIQESKIRGRLGKWHKLYRWKLQELEGNKRI
ALSFP-DD-VFSTMFLEYVDKMLARGQRALQEINDP------------------------------------
YFDQWTKEVIASNSFCQQDFTLARFAEID-----------------------------------DAMFMKEL
HSITSDLPVRDLRIFLNK-VMKK--MSVWDTNLAIHMLSAYDSENSLSEKQYRVLWTDLSF--PHLFCAIAH
-KYYLGQKR---SWSDEKYIWALQNIIALEDSK---EEFLQNFSDIYHEIKSNSGGK---------------
---
>CotS_C.thermocellum_DSM_4150
----------------------------MPINHEPLFDVLSQY-DIK-VVSIRNESYK---DKKGVWWIQTP
------------------------------DEYKILKKISNSE--DTFKYILSAAEHLRK-NGVNIPAVYKT
KDGK-----DYVNINGTCYVLYEAVE--GKNPSYNSPEDFRAIVRELAGFHAASVGFS--------------
-----------------------------------------PPDNTKPKIHLGKWVEQYTEQVEDMNRFYQT
ELEKSEND-RIGKVIIEEFPAFYERAKQAIEGLKRK------------------------------------
EYQDWVEKVKSRGGLCHQDFAAGNLLKNPS----------------------------------GKIFVLDT
DSITIDIPARDIRKLLNK-IMKK--NGKWDLEILRKFIRIYQSENPLSFSEWTVVKFDLMF--PHLFLGAMN
-KFYYKRDK---EWSFEKYLKRINEMTALEKTI---TPVLENFDSIVYEEINQRKD----------------
---
>CotS_Geobacillus.thermodenitri
-----------------------------MQSQWIADKVLELY-PYE-VEQIELQVMRP---KETVWTVATD
------------------------------EGEKVLRQRATLP--ERMLFYAEAHWHLQQ-RQFPIAPLCRT
KNGG-----LCVAGGEQAYALYDAVS--GKEVGYYNVEQLENAFEFLGLFHAASQQFS--------------
-----------------------------------------PSSKAKKRNRLGKWPKAYTWKLQELSGYKKM
AAAFA-DD-PFSVLFFEAADAMIAAAEEATKRLESD------------------------------------
AYAEWTAGPNRWTGFIHKDISLSHLIETE-----------------------------------ETMMMSYL
PAVVIDLPVRDIQVLLHK-IMKK--MAVWDEELAARLLQAYHRVHPLTDDQYRLLEAELLF--PHLFASVAR
-KYYLKAKD---NWSDEKYMWEIQTAITVERSK---QDALRRTP-----LPSLL------------------
---
>CotS_Brevibacillus.brevis
-------------------------------MDDLIKKIQNKY-DMTVLQHKTIRDTP----KSLVIYLETT
------------------------------NGKFIGKAFPLQK--ERLHFILNAEAHLRK-NGVHIPDIQRT
KNNK-----RYITHKEKLFVLHQRLS--WPNIAYTSPLRMERIGTVLGKIHARSLGFS--------------
------------------------------------------SKYGKLYNGAEKWSAEYKTDLAALEKWELQ
HTGKNDRK---YATIAEYLPFFKQAGVTAKEHLLSSP-----------------------------------
YFSTWKREPLTKHFLCHGDFNNGNLLVSN-----------------------------------QRIAIIDW
EDVRYDFPSKDIARVLSLAMRKND---QWNEDLFSHLLRGYLRENPLSIRQLHLLFVDLAF--PHIIERFLR
------KKQ-----YDQMNIAEIQQFCNREALK--IAFMLDEMKAHV-------------------------
---
>CotS_1_Desulfotomaculum.acetoxidans
------------------------------MEKDNMKLVFKDVYGLDIYEVNVLAEQGR----KKVWGLQTS
------------------------------KGKKVWKRIPSSN--DRAGFMIRVMEYLIS-KGIKVPRVIKT
RFNK----NYYLSSQGEIYLLTDWVDG----IKPNFNDHLKEIVITLAKFHKYTAKIE--------------
------------------------------------------ANPSSVFDWRGIWPATYEKRQKRLSEIKQA
LRGNNEVS----GGLLKSIDYFLKKSKSAANSLENS------------------------------------
YYHVWLRRKGAKTGLCHRDFIPQNLSLTG----------------------------------AGELCIFDF
DTLTMDIPAMDLRKLINTCCKEK---GKWDVEIVKSVVNFYNSVNPLLDREWEVVFIDLMF--PHFFYSLLN
--KYYTESV----QVANYNIERIHETILFEKSK---KDMWKDFQDIMGERGEY-------------------
---
>CotS_2_Desulfotomaculum.acetoxidans
-----------------------------MSDVKSLRQVLAEYGLDNAKCSLLSDKGKK-----SVWKIETS
------------------------------NGYAVLKKMPGSP--SRTSWLARAVDHLGR-SGVNLAPLIPS
LKGS-----LSVTADQSGFILYRWLS----GRQPEFNRDLDAILESMACFHRGGKGFQ--------------
-----------------------------------------LSPEEHMRSHLGKWQDDYAKKRIILTQIRDE
KCHIMFDK--FSRQVFKYINHFIDKIVRMEKQLKAS------------------------------------
CYKEWVNRLGVNTCFCHQDFSPKNLRWHE-----------------------------------GKVYIFDY
DSLTLDIPARDIRKLINKLMKKK----SLDKILLNNIYQLYNKYNQITESEWRVVLTDLLF--PHLFYGIVT
KYYFKRAQD----WSKEKYIKKLESMINVELEK---DIVLSGLI----------------------------
---
>CotSL_Geobacillus.kaustophilus
---------------------------MASKRSRLLFDILSSY-DLT-GTEVDIMKELKN---DKVWLVRNK
K----------------------------TRERYVLKRLSEDK--TNFPILLHSKLYQEG----FHVPKIFQ
TKTD----QYYIHRKGHYYYLMDYIVPSGTKPSFQQRIEGLARFHAHSLFADWIG-----------------
----------------------------------------------PCPSSFPEPKDVLSAHRQKAAQLEEQ
AKAIDHGD-----TLSHIMEQMARIANQSYAWLEKS------------------------------------
NLADFCRTAKERKAICHGDYNSNNLLLAEN----------------------------------HEVMMIDF
DRAYYGLPLDDFRFLLVS-LMKNP--KNDAVKRTKLLFDLYFSICPLYAPYKSVYVADAMF--PHVFYSEAV
G--REKQKQ---ALHSPSSLDLLTRLAEQETKK---FAFLSDFFKSEG------------------------
---
>YutH_B.subtilis
---------------------------------MVKGTIKEKY-GIH-IRQLSMYQH--------TYQCFQT
-----------------------------PNSYFLIVPVSQFS--ETELAELYYMSQYLQEQSDPYVSVFIF
TKEG----ELTFEHEGKTYALLKAAPP-YSNRAF-------SIGAELAEFHRKGRGYP--------------
-------------------------------------------YEVKAAGRIGQWKDLWGKRIDQLEAFWQR
KVQTPPHE-PFDKKMIESFPYYLGLSENAIQYLVDT------------------------------------
-ELDDKPQAADSGTICHQRMERHTWS-------------------------------------PESLIRIPA
DWV-FDHASRDLAEYMRH-TFLHH-RQDFN-QQGFLFLQEYEQVTPLSSFSKRLLYSRLLF--PLHYFEIVE
--SYYMSSE---SE-KHYFEEQLDFILNDCGRY---EQFLNTAQEFMNMRAQKLF-VPRVSWLGKGSSR---
---
>YutH_B.amyloliquefaciens
----------------------------------MKSIIKEKY-GIH-VRQLSVYQ---------KYQCFQT
-----------------------------PNSFFLIIPVSGFS--QSELTELYYMSQYLQEQSDPYVSVFIF
TKEG----ELTFEDEGKTYALLKAPIP-VSNRSF-------SVGGELAEFHRKGRGFP--------------
-------------------------------------------YEVKEAGRIGQWKDLWGKRVDQLESFWMQ
KIHMSPLE-PFEKKMIEAFPYYSGLAENAIQYLVDT------------------------------------
-ELDDNPGAEDSGTICHQRMERDTWS-------------------------------------EESLIRIPG
DWV-FDHAARDIAEYMRS-TYLYH-RDDLL-KDGFLFLQEYEQITPLSSFSKRLFYSRLLF--PLHFFETVE
--SYYISHD---SE-KQYYEEQLDYILADCTRY---EQFLQTCHNMMNVRSAQVF-VPPVAWLGKGISS---
---
>YutH_B.anthracis.Ames
----------------------------------MIHHIYEHY-HMH-VKELIPLG---------PYKSFWI
-----------------------------RNKIYVLVPIGEME--EEVLVEMKKLSDYMNQQGDITVATFVP
TIHG----YYVSEIEEQNYCLLKGMRA-LERHAI-------SLGSELSIFHKRGAFFP--------------
-------------------------------------------EEIEQLSRIGEWKALWEKRLDQLEKFWQS
QVMNHPTD-VFDQLFIESFPYYLGVAENAIQYVVDT------------------------------------
-EMDDTPQLTDAATICQERFTPLLWH-------------------------------------QTKRLKLPF
DWV-YDHPTRDIAELIRY-MMIEK-KKDWE-KTIVQFVTDYERNYSLSSFGWRLLFARLLF--PLHYFETVE
--RYYQTGN---EEQKSIYRDRLEAILHDVNRS---EQFMKHFYSSLRLPVDKLG-IRKLDWLS--------
---
>YutH_B.cereus_cytotoxis
---------------------------------MMIQHIYEHY-QMH-VKELIPLG---------PYKSFWI
-----------------------------RNKIYVLLPIGNME--EEVLVEMKKLSDYMNQQGDITVATFVP
TIHG----YYVSEIEEKNYCLLKGIRL-LERHAT-------PLGSELSLFHKRGAFFP--------------
-------------------------------------------EEIDKLSRIGEWKSLWEKRLDQLERFWQS
QVMNHPSD-VFDQLFIESFPYYLGIAENAIQYVVDT------------------------------------
-EIDDTPQLSDSATICQERFTPLLWQ-------------------------------------QTNRLKIPI
DWV-YDHPTRDIAEWMRS-IITEK-KKDSE-RLIVQFISEYERNYSLSSFGWRLLFARLLF--PLQYFETVE
--SYYQTDN---EEYKSVYRDRLEDILHDMNRS---EQFMKHFYEFFRLPVNKLG-IRKLDWLS--------
---
>YutH_B.cereus_G9241
----------------------------------MIHHIYEHY-HMH-VKELIPLG---------PYKSFWI
-----------------------------RNKIYVLVPIGEME--EEVLVEMKKLSDYMNQQGDITVATFVP
TIHG----YYVSEIEEQNYCLLKGMRA-LERHAT-------SLGSELSIFHKRGAFFP--------------
-------------------------------------------EEIEQLSRIGEWKALWEKRLDQLEKFWQS
QVMNHPTD-VFDQLFIESFPYYLGVAENAIQYVVDT------------------------------------
-EMDDTPQLTDAATICQERFTPLLWH-------------------------------------QTKRLKLPF
DWV-YDHPTRDIAELIRY-MMIEK-KKDWE-KTIVQFVTDYERNYSLSSFGWRLLFARLLF--PLHYFETVE
--RYYQTGN---EEQKSIYRDRLEAILHDVNRS---EQFMKHFYGSLRLPVDKLG-IRKLDWLS--------
---
>YutH_B.clausii
---------------------------------MLERNLYDQY-KLY-CDERFTVG---------PYEGFRA
-----------------------------NNQAYIILPKDECM--A-EEVEMMAFCDFMRQAGDESVLELVP
NRFN----QSSALIDGVEAYVFKVP-E-FNEFRGVRIQSEWDLGEQLFTWHKRGQQGR--------------
--------------------------------------------QHWKKASFPPWQELWATRLEQLEDWYQA
LVNQGPQT-TTDEAFLCTYPYFMGMTENAIQFAVDT------------------------------------
-QLDVKKELHDEPTICHRRFGETSWLYMSE---------------------------------RGHIVKPPT
AFL-YDHPARDLAEWIRE-NRPMG-EIRQNWERIASFFGGYEEWQVLTPYTWQMMYARLIF--PLHYFEVIE
--NYYQAQL---PHEQREYGKQFQQLLDRETSN---ADFLGELAEEAKLSRYPQM--PLLDWLKGQTL----
---
>YutH_B.coagulans
--------------------------------MMAQAIMKKYY-GID-VWQSFFDGK--------QVRYEA-
-----------------------------NGNLYTLVPVTNVS--ENVLVELYEMSRHLVTNGDRYASAFYP
SKEK----KFLVTDGDSDYVLLENRYK-KAPGNM-------RTGRKLAKFHLRGRTLS--------------
-------------------------------------------ATITETNRMGEWKNYWEMRLEQMEKAWYR
TVEEHPDH-PFERLFAETFPYYMGLCENAIQYVVDT------------------------------------
-EMDEAPGPGDAGTICHERFSNETWG-------------------------------------RKFIIHHPF
DWV-FDHACRDIAEWIRA-QYFKK-THTFR-PDVRAFLQQYVSLSPLSPFSWRLIFARLLF--PLHYFECVV
--SYFLTRF---------------------------------------------------------------
---
>YutH_B.coahuilensis
----------------------------------MEDIISKYF-GVE-MVSSIKDSQ--------YPRYHGK
-----------------------------DGLLYTIVNVTNTS--QEYLVELYKMTDHLKTSGDLYVSSFVQ
SIDN----KFLITKDDQDYVLLQNKKR-LRPKDK-------QIGRKLAKFHFRGRAIQ--------------
-------------------------------------------DKVEFTSRIGKWHELWEKRVNQLENACAS
IVHSGPTE-EFDRLVADAFPYYLGLAENAIQYLVDT------------------------------------
-EIEGEPEREDAGTVCHARFSNHSWG-------------------------------------KEYWIRFPF
DWV-FDHASRDIADWMRA-QYLTR-NRTYI-PDIQKFVQDYQTITPLSSFTWRLTYARLLF--PLHFFEVVE
--EYYTSKT---DHHRHEISDKLERYLKFSGDF---ERFLGSFFDIVQVPVYSRN-IPRIDWLSTSNK----
---
>YutH_B.halodurans
---------------------------------MFERNVYDSF-QLY-CDSRFRTG---------RFQGFYA
-----------------------------QGQPYLLVPREQIE--PDEEAAILEMGEYLQRAGDGTVLKLIK
AKTG----PLHAKIDGQDVYLFQIPYE-YERFG--MLQTDEDIGRHLATFHQAGAQYV--------------
-------------------------------------------GTAYQKGAYGKWPRLWEKRLEQLEEWHQR
LLAQGPRT-LVDEQFLFTFPYYLGMTENAIQFAVDA------------------------------------
-HYDEGGIERERGTICHKRFHNDTWIRL-----------------------------------ENGRLKVPT
EFV-YDHPSRDLAEWLRS-KELEIARPEDRALAIQSFLHAYGQHAPLTRLCRRFIFARLLF--PVHYFQTIE
--DYYSCQI---EEKRRTLEKEVLHLFEKETTH---EQFL-RMVQQQLFPNPHEL--PMVDWLLAEPLPTPF
ATR
>YutH_B.licheniformis
----------------------------MQEVMSVKELIKEKF-GIY-IRDLTSYL---------SYQAFHT
-----------------------------PNSMFLIVPVSHLS--QDELAELFSMSQYLQEQRDPYVSSFIL
TKDG----EMTFEENGVSYVLLQAAPR-MTNRSV-------SFGAELAEFHHKGRGYP--------------
-------------------------------------------YEVKETSRIGQWKELWGKRLDQLEQFWIQ
KTQARQLQ-PFEKQFIESFPYYLGLTENAIQYLADT------------------------------------
-ELDDQPQAADSGTICQQRLTCEALR-------------------------------------REPLIKIPM
EWV-FDHAARDLAEYAR--SLFHE-RKNFN--EIMLFLQQYEQAAPLSSFSKRLMYSRLLF--PLHYFETLE
--GYYISPE---SE-HHYFESRLDYLLSQAPAY---EQFLNGFQEMAGMRSAGLISMPPVNWLKRTP-----
---
>YutH_B.pumilus_7061
----------------------------MNAGENMKETIYHTF-GID-VRQLMPYG---------SYQSFQT
-----------------------------SEALFIIVPVSHLR--EEELTELFHISQYLLNAGDPYVAVFEL
TNEE----KPTFTHGKELYALLKAAPP-ISSRSF-------QQASELAAFHVRGRGFP--------------
-------------------------------------------YEVSETKRVGAWKELWAKRLDQLEGFWMQ
QMHQKPLE-RFEKKFIESFPYYLGLTENAIQYLVDT------------------------------------
-ELDDEPKECDSGTVCHQRFSRRTWP-------------------------------------HEQPLRLPV
DWV-FDHPTRDIAEYLRE-TFVQH-KEDLI-EEGFSFLQQYEQVTPLSSFSKRLLYSRLLF--PLHYFEIVE
--GYYMSGE---NE-KSYYEERLDYVLNDANRY---EYFLKVFQEMSAMRSGGSL-IPPVGWITGPLI----
---
>YutH_B.sp_14911
---------------------------------MLRQMLKQHF-GIQ-AEEELRIGL--------HEAFKK-
-----------------------------DNQLYIPMEVG-LE--EEDLAELSLIASHLQQTGDKTVSTFLQ
TTEG----KHSSVWEQKSYCVLKCPNA-QPRKGY-------QSGRKLAKFHYRGRLIS--------------
-------------------------------------------SPITRTSRIGQWKQLWEKRLDQMEKVWNS
MLFQQPEH-ELDRMFLETFPYYMGLAENSIQYLADA------------------------------------
-ELDDEPGPADSGTVCHERFVSSTWGS------------------------------------DDYLIKSPF
DWV-FDHASRDLAEWSRE-RYFRN-IKTYQ-PGLSQYLKEYQTVEPLTSFSWRLLYARLLF--PLHYFECIE
--NYYGNPT---EHQRHLSEEQLGRFLQHTGDH---EEFLGKFFEMAEVPAAKMK-LPPVDWLKR-------
---
>YutH_B.sp_SG-1
----------------------------------MEDILTKHY-GLQ-PERSFKDGR--------AERYMA-
-----------------------------DGSIYTIVNVTNRE--QDNLAELYNISEHMKKYGDRYVSSFVP
TAEG----RFLVNEKEQDYTVLKNNPH-SRNAEE-------KIGRKLAKFHHRGRAIE--------------
-------------------------------------------EKITHISRIGQWKTLWEKRIEQMEKAYQM
VIENHPVD-EFERMFIDSCPYYIGLAENAVQYLVDT------------------------------------
-EMDDNPVYTDSGTVCHERFSEGVWG-------------------------------------REITIRNPF
DWV-FDHGGRDIAEHVRE-RYFKR-QNTHQ-PDIQQFLRDYQSVEPLSSFSWRIVFARLLF--PLHYFETVE
--NYYLSES---EGQQFQMGEKLHGYLNSTRHY---EQFLGNFYGVGEVPVKSYG-IPVVTWLR--------
---
>YutH_B.thur_97-27
----------------------------------MIHHIYEHY-HMH-VKELIPLG---------PYKSFWI
-----------------------------RNKIYVLVPIGEME--EEVLVEMKKLSDYMNQQGDITVATFVP
TIHG----YYVSEIEEQNYCLLKGMRA-LERHAI-------SLGSELSIFHKRGAFFP--------------
-------------------------------------------EEIEQLSRIGEWKALWEKRLDQLEKFWQS
KVMNHPTD-VFDQLFIESFPYYLGVAENAIQYVVDT------------------------------------
-EMDDTPQLTDAATICQERFTPLLWH-------------------------------------QTKRLKLPF
DWV-YDHPTRDIAELIRY-MMIEK-KKDWE-KTIVQFVTDYERNYSLSSFGWRLLFARLLF--PLYYFETVE
--RYYQTGN---EEQKSIYRDRLEVILHDVNRS---EQFMKHFYSSLRLPVDKLG-IRKLDWLS--------
---
>YutH_B.weihen
----------------------------------MIQHIYEHY-HMH-VKELIPLG---------PYKSFWI
-----------------------------RNKIYVLVPIGEME--EEVLVEMKKLSDYMNQQGDITVSTFVP
TIHG----YYVSEIEEKNYCLLKGMRM-LERHAT-------SLGSELSIFHKRGAFFP--------------
-------------------------------------------EEVEQLSRIGEWKALWEKRLDQLERFWQS
QVMNHPSD-VFDQLFIESFPYYLGVAENAIQYVVDT------------------------------------
-EMDDTPQITDAATICQERFTPLLWQ-------------------------------------QTKRLKLPF
DWV-YDHPSRDIAECIRY-MMIEK-KKDWE-QTVVQFITDYERNYSLSSFGWRLLFARLLF--PLHYFETIE
--RYYQTGN---EEQKGIYRARLEIILHDVKRT---EQFMNHFYESFRLPVDKLG-IRKLDWLS--------
---
>YutH_Geobacillus.kaustophilus
----------------------------------MEEWVREQY-GMR-VERLERSG---------RHAAFWH
-----------------------------RQERFLLVPADGQS--EAEMEERQRMSRYLRAKGVDGVGELVK
TTSG----TYIASYNGQPLALVRAPLP--AARFR-------SLGRELAVMHECGRTCP--------------
-------------------------------------------WPIVACRRIGQWRELWAKRIDQMEAFWSS
KLASGPSS-LFDRLFIESFPYYLGLAENAVQYVADT------------------------------------
-EIDEEPGRIDYAAFCHERLPEAKWV-------------------------------------GGGEAKLPT
DWV-YDHCARDLAEWVRH-LYEKS-GLGCQ-RAVRQFFQEYEHAAPLSPFAWRLVYARLLF--PLSYFECVE
--AYYIAVD---ESERTRREGELRRLLDRSHEY---ERFLAAFAKIAGI-SNR-IRLPAVEWLPPA------
---
>YutH_Geobacillus.sp.WCH70
----------------------------------MQEFIRHEY-EIS-AERMGKIG---------RYYTFLY
-----------------------------KNQYYTVIPVHGRT--EAEIKELQKMSHYLISKGDVTVASFVP
TKSG----ELVAYNARQPIVMVRTSIP-PYARNI-------SIGRELAKFHQRGRTCP--------------
-------------------------------------------ISIIHCRRIGQWKEFWGTRLDQMEQFWRR
KIEMGITT-MFDRLFIESFPYYLGLAENAIQYVADT------------------------------------
-ELDEEPVGIDYATFCHERLPDAKWI-------------------------------------EGKEHKLAT
DWV-YDHCARDLAEWVRQ-IYTKR-QNASV-ERIRQFFRDYEQVTPLSAFAWRLIYARLLF--PLHYFECVE
--GYYISEG---EREKQAYEQTLRHIVNHSREH---EQFLASFVDIVGL-SNRQLHLPKIDWFSHVS-----
---
>YutH_Geobacillus.thermodenitri
----------------------------------MEKWVYEQY-GMR-VERLERRG---------THTAVWH
-----------------------------KRERFLIVPADGRS--EAEMEERQQMSRYLRTKGVGSVGELVK
TTSG----TYIATWDGKLMALVRAPLP--TARFR-------SLGRELAVIHEYGRSCP--------------
-------------------------------------------LPITACRRIGQWRELWAKRIDQMEAFWAN
MLATGPAS-PFDRLFIESFPYYLGLAENAIQYVADT------------------------------------
-ELDEEPLRIDYAAFCHERLPQAGWV-------------------------------------EGAEAKLPI
DWV-YDHCARDLAEWVRH-LYHQR-GLGCQ-RAVRQFFQDYGHLSPLSPFAWRLIYARLLF--PLPYFECVE
--SYYTAVD---RNEQVRYEGELHRLLDGSHEY---ERFLASFAEIAGI-SER-VRLPVIEWLPSA------
---
>YutH_Oceanobacillus.iheyensis
--------------------------------MPLTEMLSSLY-SIQ-PEGKRTIDS--------REGYTK-
------------------------------GEYIYFTISGRNR--ETILMEQATLAYHLKGNGFANVAYPIA
NSNG----DWFTSYGDDNWMVLELDMS--------SIRHSNDSGIQLGNIHQIGSSFQF-------------
--------------------------------------------EPKTISSYGKWKELWIEKLTFFEEEIQK
QAKEQQSD--YYRELMDILPYIVGISENAIQYLQES------------------------------------
-EKEQRVLETDQGTSCFVRWNP-----------------------------------------EGNQVLWTD
GFV-FDHPTRDIAEYIRW-CFVN----NRDKEDILQFLNDYQSYQPLSVFGWRVIYARLLF--PIHLYDLLE
E-GFTTRDM---SMLIQMQTIQENYEKQLRDFY---QIVGVNISDWQIPVVNWL------------------
---
>YutHL_Brevibacillus.brevis
--------------------------------MEEKELLQEKY-----GFELQGYRTTG-----ASKVLETD
------------------------------RGLYYMFEAPAGYK-YKSKFIEKVKQHLSQQQNIRLLKLVNT
TSGQ-----AHIVDDEQLYYLYRGVR------EAVPENPYYAGGQSLAQFHLATSDFSS-------------
------------------------------------------DKMFIPYSSLGNWPSTWQKKLRNFNEYRDA
MDEENVELAPMDEYLLTCFTYITQLGELSVQYLLDAG-----------------------------------
-YDKVVKETASLGKVAYQNFDQGYMLWKEK----------------------------------DVRLMAGE
WNWVLDMRTRDVGQWIKAETKRN----SWNEEAVSSFLDGYNSVSALLPAEYAVIYALMLY--PGRFLKLVE
TYMELPVEERQEVNIQAWQTQLEDELTKMEDGLRKYPLFIAERYDVSIPQIDWLWRKKDDQATSFRYEETQS
---
>YutHL_Clostridium.ramosum
-------------------------------MVSELEILQRFY-------QIYLEQE---------------
---------------------------------------------SDFFSFQGNFYYLCKVNNFTNDYPYYV
NALG----------LNGFMVVNNCFN---RPISMDYILYTYQIEDYHFEMFLQYSLRP--------------
---------------------------------------------LDIQVEVLKIKESWCAILDEAKCKIGN
YASRISHF----EHFVVLSYYYQGLGEAAISVLNEIK-----------------------------------
------------ETKLVAGIEHFNMIDN-------------------------------------YEMLCCP
ANLVIASRVKDLASSYKN------------NLISVEQLEQYIQISALTVDEIIYLYSRLLF--PSEFMQLAI
NDDCNDAQI------KKTLLNMYQNIDNQKASLVIAWQMLNKYTRLPKIAWL--------------------
---
>YutHL_Clostridium.spiroforme
--------------------------------MVSKLEILQRFYQIYLDYESDYFTYQ--------------
------------------------------GKQYYLCQIN------NFTNYYESYIHALNLIGFQVVYNCFN
RPVS------------MNHILYTYQN--------EQYNLERFIIQSLIPLN---------------------
-----------------------------------------------QKINILKVKESWCKILDEAKNKIGN
HASRINHF----EHFIVLSYYYQGLGECAISILNQIK-----------------------------------
-------EKELLSGIEHFIFEDSYG------------------------------------------ILCAP
GNLVIASRIKDLSAAYKN------------QLITINQLEEYINYIRLSNDELIYLYARLLF--PDIFFKNVI
KEDCNDSLM------KKKLLNIYQNIDNEKRTIKDAYQMLYNYVNIPYIPWL--------------------
---
>YsxE_B.subtilis
--------------------------------MEDTQSVLQEY-GLT-AQFIEPVSP-------LVWKVYTD
------------------------------YGIFALKKLK--E--GRGKHFTDHMVAIEEKGFRSFVPVYRT
NSGE---FFSAGIQYGDIYYLMPWLQF---DQEEERDQKHAYLFRETARLHERTAQELK-------------
------------------------------------------VRRDEIERYYGQTKKKWEQDKIFYEQFVDR
AEKEWYLS-PFELQAITYFSETISAVNFALERLEDW------------------------------------
-YESAKEKDVSRVVMNHGSLSIHHFLYNDA----------------------------------GTGYFTNF
ERASVGPPQNDLLGFYTK-MFRGF---PKACPECVEWFYGYTKSFPLREAEVSLFLSYMAY--PAAMYKVLN
G--YQTGKR---QHEKEECTQLLKAYWQMKN----IEPFVMKIHQIEQEKKFQAENESTS------------
---
>YsxE_B.amyloliquefaciens
--------------------------------MEAVQSVLQEY-GLA-AEYIEPVSP-------HVWKVYSN
------------------------------YGIFALKQLK--P--ARSSEFTDLMIEIEEKGYRSFVPICRT
YAGD----FFAGRQTENSYYLMPWLQY---DQEEERDQKHVYLFKEVAKLHSATVRDIQ-------------
------------------------------------------IRTEDISGFYEATKRDWENDKLVYEQFADR
AEKEWYLS-PFELQAVTYLTETVSAVNFALERLEEW------------------------------------
-FDAAKDHDKTRAVINHGSLSSRHFLYNDA----------------------------------GSGFFTNF
EKAALGPPQNDLLGFYSR-MFRSY---PKACPECLDWFYTYHKSFPLREAEISLFLSYMAY--PSAMYKVLK
R--YQTGQR---GSEKEECTQLLRAFWQMKN----VEPFLMKVHQIEREKKIKAENESSS------------
---
>YsxE_B.anthracis.Ames
---------------------------MDMELRNRYEPIVRQY-RLD-TQHMEEHGS--------VTKIYTN
------------------------------QGPYALKKIEGGK--LERNNFLHHIQYLKEKGFSNYVPIYHA
TDGN-----YILSDGTYNYYLMPWLER--AEGNGEDNDQYHKMFQTLGTLHQKTVKEET-------------
------------------------------------------YTEEDLEKHYTNISDRWESDGEMLEEFLVE
SEAKWYMS-PFELQYCTYYHHVMRAREFATKQLNEW------------------------------------
-NDAMKEKETTRITFVHGNVSLNHFLFDYE----------------------------------RNGYFISL
EKSKFATPVQDIVGFYSR-SLNTY---PIARSDRFEWYQMYQKNFPFTKEEQLLMFAYMTY--PSQFIRQIQ
S--YKKRRE---RRNEENELLGVKSLQQAHWLVSNIEYFLSQLQAAQQGNG---------------------
---
>YsxE_B.cereus_14579
---------------------------MDIELRNHYEPIVRQY-RLD-TQHMEEHGN--------VMKIYTN
------------------------------QGPYALKKIEGRK--LERNNFLHHIQYLKEKGFSNYVPIYHA
TDGS-----YILSDGTYNYYLMPWLER--AEGNGEDNDQYHKMFQTLGTLHQKTVKEET-------------
------------------------------------------YTEEDLEKHYTSISDRWENDGEMLEEFLVE
SESKWYMS-PFELQYCTYYHHVMRAREFATKQLNEW------------------------------------
-NDAMKEKEKTRITFVHGNVSLNHFLFDYE----------------------------------RNGYFISL
EKSKFATPVQDIVGFYSR-SLNTY---PIARSDRFEWFQMYQKNFPFTKEEQLLMFAYMTY--PSQFIRQIQ
S--YKKRRD---NRNEENELRGVKSLQQSHWLVSNIEYFLSQLQAAQQGNG---------------------
---
>YsxE_B.cereus_cytotoxis
---------------------------MDIELRNRYEPIVRRY-QLN-VEHIEEYGN--------VMKIYTN
------------------------------QGPYALKKLPNQR--LERNHFMHHIQFLKEKGFSNYVPIYHA
MDGN-----YILSDATYSYYLMPWLEK--VDGNDEDNGQYHKMFQTLAMLHKKTVREES-------------
------------------------------------------YTEEALENHYTNISDRWEQDGELLEKFLVQ
SESKWYMS-PFELQYCTYFHHVMRAWDFATKQLTDW------------------------------------
-YEVMKEKEKTRIALVHGNVSLNHFLFDYE----------------------------------RNGYFISL
ERSQFATPIQDIVGFYTR-SLNTY---PIARSDRFEWYQEYQKHFPFTKEEQLLMFAYLTY--PSPFIRQIR
--SYVNKKQ---VRNEQKEFKNVKMLQQSHWLVSNIEYFLSQLQAAQQENGS--------------------
---
>YsxE_B.clausii
-------------------------------MNPLYEAILFYY-DLQ-PRAIEQVGQK-------LIRVETD
------------------------------QGIFALKETDIDR--IRADEFVHAIRKLTKLRFRQFIPVLPT
KFGE-----YTLFAGDKSYYLMPWVN---EVDYQSRVSIEETIADHLGVIHRITVKTQP-------------
------------------------------------------AVKESLDGSCERLLARWDRHFLEMSRFADQ
AEQNRYIS-PFELTFLTHYGLLEQLAEGARNQLEKW------------------------------------
-YEATLEKRSYRSVLTHGRLSRHHAMATET----------------------------------NELLLFNF
EQASLDTPARDLAAFCRR-SFPY---ALWEEDEVFRWLHRYEQHLPLLDSEKHLLCAYLLY--PDPIYYAIG
D--YRHGG------NELEHVRRLEKRIMAMRKV---QRFVSKLAPAEEKKEA--------------------
---
>YsxE_B.coagulans
---------------------------MTDLSQQDINRIVKHY-GLN-AEYVGRYGK--------VYKIYTG
------------------------------QGIFALKKIA--P--QNGMGFIRHVQSLYQRGYNRIVPVYPA
LDGR-----YGVLYNGALYYLMPWLPN---EEKEARGEKHQKMFRELARLHSLSVKDT--------------
-----------------------------------------EISIEKRREYYEETLSRWYGQQDFLEEFLER
CEEQVYMS-PFALLYCTFYNETNQALKFSIRQLENW------------------------------------
-YEQSKEMEKARTVTIHGKISTEHFLYDER----------------------------------GLGYFTNF
ELAKNAAPFYDLLPFLSR-TLDSY---PSRFDDCVDWVKTYFSYFPLKEDEKSLFFSYLAY--PAPIIQTVE
--EYFANEG---KRHEARAVAKLQEKYWRMKNT---EYVVMQLSQGAAPAS---------------------
---
>YsxE_B.coahuilensis
---------------------------MDQQLMVKLKEIAQYY-QLE-LHLAERYGK--------CFKLYTN
------------------------------KGNYALKELP--A--ERGVDFVHQIQHLFQSGYNRIVPVYPT
SDGR-----YAVLYDSSLYYLMPWLLN---DEKEDYDGKHVKLFREVARMHSITSKEIP-------------
------------------------------------------IEQKARQEHYDEISLRWEKETEFMEEFLSR
CEEQDYMS-PFEQLFCLYYHESSLAIRFAKEKLDQW------------------------------------
-LEQSKEREKVRTVFVHGKLSTEHFLYDDR----------------------------------GTAYFSNF
EKMKQAAPFHDLLPFLSR-KLYTY---PKDQEEVYNWLDLYFRHFSFKR-----------------------
------------------------------------------------------------------------
---
>YsxE_B.halodurans
----------------------------MQQAQLPLEAILYQY-DLY-PEAVEDHGEN-------VKKLVTK
------------------------------HGLFALKKTQMTR--SQADWFVYCMRKLDRLGYRKVVPLVPT
KFGE-----YTLTDRDTSFYVMPWIESIPYNARESQEEKLADQLGVIHRLTVKTQPFS--------------
--------------------------------------------KEQLEASYNELRDRWDSRWLTMNRFADQ
AERKTYMS-PYELTLLTHFSFLEHMAHTAKESLEAW------------------------------------
-YETCLEKEKYRSVLCHGRLSRAHAFFNER----------------------------------HEPLLFNF
ERAALDTPARDLASFFRH-SFPH---ALWSEEEGHRWLYRYEQHLPLLEEEKRLLHAYLSF--PDPVIYGIE
A--YQQQSG---PPSEVKHVKRLEKRLLNLRRV---ERFSKSLLPTPAINESGLS-----------------
---
>YsxE_B.licheniformis
--------------------------------MEGIQSVLNEY-GLT-PEYMESVSS-------KVWKVYTD
------------------------------HGVFALKKLA--A--SRNTRFTEQMIMLEEKGYRQFVPVYRN
RTG-----EFLTQAGEDVCYLMPWLTL---EREEERDQKHEYMFKEIALLHQRTEKELG-------------
------------------------------------------VRREEILGHYERTKRKWEQQKQKYEAFIMK
AENEWYMS-PFQLQAAMYFKETISAADFALARLEDW------------------------------------
-HEAMREKESARMVLNHGHLSVRHFLYNDT----------------------------------GTGYFTNF
EKAGHAPPANDLIVFFTR-MFKTN---PVMCTECVNWFYTYHNVYPLREEEIGLFLSYMAY--PGPVFGVLN
R--YEHEKG---LGEKEACTRLLKAYWQMKN---AEPLVMSIHETEENRKLQEETESPSS------------
---
>YsxE_B.pumilus_7061
--------------------------------MDEIQSVLYEY-GLE-AEYVEPVSP-------AVVKVYTK
------------------------------QGVFALKRVK--A--SRHMQFTEQMLELESKGYRSFVPIYRT
KSGS---FFSSHRESQYAYYLMPWLTN---EKREEQDDKHEYLFQEIARLHKRTEVMMD-------------
------------------------------------------ITEQEIEAHYTQIKTKWETEKDMYERFIER
AEQTWYMS-PFELAAAMYFSEAMSASEFALERLEDW------------------------------------
-HEEMKDKETTRVVLNHGQLSIHHFLYNDV----------------------------------GTGHFTNF
ERSKKAAPIYDLLTFYYR-TFKTY---PTSCPECTSLFYTYQKGNPLREEELHLFLSYLAY--PQGLFDTVK
T--YE-AGG---QDEMESCQQLLRAYWQMKN----SEPTVMKIHEIEQARRLEEEQSASSSAE---------
---
>YsxE_B.sp_14911
--------------------------MEGSNRLAAVSPILKHY-AVQ-PHFVEDYGR--------TRKIYSD
------------------------------KGVFALKKLK--A--KHGTDFIRQVQSLYQKGYNRIVPIYPA
ADGR-----YAVFHESELYYLMPWLAN---EEKENRFERHQQMFRELARLHTLSLKEVN-------------
------------------------------------------VTSEERQEHYEKTLLAWEKETEFCEGFIDE
CERKQYMA-PFELLFCLYYHDITQALKFSKGKLKDW------------------------------------
-HEKTKDDEKARTVIIHGKVSTEHFLYDER----------------------------------GYGYFSNF
EKSRQASPLHDLLPFLSR-SLRSY---PKRSDESVEWLYTYFKYMPFKQDEMLLFQSYLAH--PGPVLREAE
N--YHKNRG---SADERKLVQQFQRQFWLLKNT---EYIVMRIDEIERQKQQAQEAAKAQAEQEGAPDNSS-
---
>YsxE_B.sp_SG-1
-----------------------------MANDQILTAVLKPY-GIK-PHFVEEFGK--------IVKVYTE
------------------------------KGTLAVKKIP--A--DTGVDFVRNVQHLFQSGYHRIVPIYPT
QDGR-----YAVWHENDLYYVMPWLAN---EVKENHFERHQTLFRELARLHTLSSKEQK-------------
------------------------------------------IRKEEREEHYETMNERWEKEQNFLEEYIEL
CEKEWYMS-PFQLSYCMFYGDASQALKFARKKFDSW------------------------------------
-YEVSKDLEKVRSVVVHGKISPEHFLYDER----------------------------------GSGYFSNF
ENTRISSPIHDLLPFLSR-TLKTY---PKAYDECFDWLMTYCSHFSFRNEEKLLFLSYLAY--PSGLISVVK
K-YHETPRE---KRNEIKFLRKLQHHYWLLKNT---EYIVMKWEEWEQRNKEAKQNAQEGASSS--------
---
>YsxE_B.thur_israel
---------------------------MDIELRNHYEPIVRQY-RLD-TQHMEEHGY--------VMKIYTN
------------------------------QGPYALKKIEGRK--LERNNFLHHIQYLKEKGFSNYVPIYHA
TDGN-----YILSDGTYNYYLMPWLER--AEGNGEDNDQYHKMFQTLGTLHQKTVKEET-------------
------------------------------------------YTEEDLEKHYTTISNRWENDGEMLEEFLVE
SESKWYMS-PLELQYCTYYHHVMRAREFATKQLNEW------------------------------------
-NDAMKEKDKTRITFVHGNVSLNHFLFDYE----------------------------------RNGYFISL
EKSKFAPPVQDIVGYYTR-SLDTY---PIARSDRFEWFQMYHKNFPFTKEEQLLMFAYMTY--PSQFIRQIG
--SYRKRKD---NRNEENELLEVKSLQQSHWLVSNIEYFLSQLQAAQQGNG---------------------
---
>YsxE_B.weihen
---------------------------MDIELRNRYEPIVRQY-RLD-TQHMEEHGS--------VMKIYTN
------------------------------QGPYALKKIQDRK--LERNNFLHHIQYLKEKGFSNYVPIYHT
TDGN-----YVLSDGAYSYYLMPWLER--AEGNGEDNDQYHKMFQTLGTLHQKTVKEET-------------
------------------------------------------YTEEDLEKHYTNISGRWENDGEILEEFLVE
SEAKWYMS-PFELQYCTYYHHVMRAREFATKQLSEW------------------------------------
-HDAMKEKEKTRTTFVHGNVSLNHFLFDYE----------------------------------RNGYFISL
EKSQFATPVQDIVSFYSR-SLNTY---PIARSDRFEWYQMYQKNFPFTKEEQLLMFAYMTY--PSHFIRQIQ
S--YTKRRK---SRNEENELRGVKILQQSHWLISNTEYFLSQLQAAQQGNG---------------------
---
>YsxE_Geobacillus.kaustophilus
----------------------------MAAQADRYEAVLAQY-GLR-PERMEQRGK--------AVKVYTN
------------------------------RGVFALKPLE--S--EQEAVAVWQSLQHG---GPRCLPLYLT
RRRS-----LFATEGGRLYYLQAWHDG----ESKVEKDAVDAFFRELARLHRATVRTIEVS-----------
--------------------------------------------EEEAAAYRKQKKDEWQRARMVWEERIER
YEAAWYMS-PFQLQCCTYFHEVMRAYSFAEERLDVW------------------------------------
-EETLKETKQWRIAWVHGKARLSHYIPP---------------------------------------YWISW
ERAHWNSPLFDVIAALRF-HVQTM---PPLGREWLEGMGEYEKELPLSDGERAFLYSHLAE--PRGFVRCLE
R-YEAASRN---ERNEREYVAALQRRYLAFKNM---EALVMHLVQRDAARQQEEAVDNEPPADESSNG----
---
>YsxE_Geobacillus.sp.WCH70
---------------------------MNRERIEMYTPILQQY-GLK-PFRVDDYGK--------VKKIHTN
------------------------------AGLFALKEIT--N--AREMAAIQQSYIFY---GKQSVPLYLS
KQG------FPFVSYGRHYYLMPWISS---DERKEKREHVRSFFRDLAYLHQKSLKQID-------------
------------------------------------------INEEEIRNYYENKKREWERQRAFLQSYVEK
CENAWYMS-PFQLQCCTYFHETMQAYWFAETELEKW------------------------------------
-YEKMKETKKWRIAWIHGKARLSHYIEMEN----------------------------------DNRYFFSW
ERASWNSPLFDVIIALRY-HMRTF---PPIGDEWVEGMEEYGKTLPMLEEEWSFLFSHLAQ--PHFLYRCIY
E-YEMKRQN---RKSEREYVSELQRRYFTMKNM---EYVVMRLVQRKEAEEAKSTPDETPPQ----------
---
>YsxE_Geobacillus.thermodenitri
----------------------------MAIRSETYRAVLHQY-GLQ-PQRIEQRGK--------AAKVYTD
------------------------------RGIFALKMLD--G--EQEAAAIWQSLHYY---GRHCPPVYWT
RHRS-----LFAAEGGRLYYLHAWQDG----EARAREETVRAFFHGLSRLHRATVRTVEVS-----------
--------------------------------------------EEEVAAYRKQKKEEWQRERTVWEERIEQ
YETAWYMS-PFQLQCCTYFHEVMRAYLFAEDQLTAW------------------------------------
-EEALQETKQWRVAWVHGKARLSHYVAP---------------------------------------YWISW
ERAHWNSPVYDLIAALRV-HVQTL---PPLGQEWMRGMDEYEKELPLSAGERAFLYSHLAE--PRGFVRCLE
Q-YEAAPRK---ERNERKYVAALQRCYFAFKNM---EAIVMHLVQRDAARQQEEAIKHEEPEQGDDSG----
---
>YsxE_Oceanobacillus.iheyensis
--------------------------------MDILKEVLEHY-SIY-PLEIEKVTN-------RLFRVHDG
------------------------------MRDYALKRSYLDE--NNIESWVSIYHVASERNISEILPVYVT
KDGS-----LYQKHEHFYYYLSPWVD---IPRNMDINYQIESTMQTLALIHKKTKQTER-------------
------------------------------------------IKIDKMKKDFEGFQSFNRNIPDGLKENIVH
FESRRYMS-PFELIACSQYKAVVHASELLQNKINAI------------------------------------
-FEQEEDSISWSKSLCHGKLDPSHCRGG---------------------------------------YLLNW
EEASFDHPSTDIANYFQH-ITGHY---DQPIEEMKQAFKLYRKTNHLTVKEIHLLTINLLN--PAHYIRVVQ
N--FTEQRT---KKSMLEQTRELQHQFRRLQFGMTWVDFIQEEYETINVDTN--------------------
---
>YsxEL_Clostridium.ramosum
-----------------------------------MNELIKEAYSLEVIGYIKVTKK--------VYKVKCR
------------------------------EGFFCLKFVEDNG----LTVVIDHIESLHLKCFLPVIRNYKK
QVLT--------SYEDKTFYLSPWLAS---DNAIVKELKLKFYYECLSYLHSTSFFNYS-------------
------------------------------------------VSKSFFKRQIEDIANIIHERQAYYNEIMSN
FEVLSYRS-PTGWMFVLNYHRIEGCLKKALELLECY------------------------------------
-EQYVCNLDTIRLCLTYNNFNYSHVMMKE-------------------------------------SKLISI
DQIKINLCIYDIYNMYQR--------IPEFIFDFDVILDSYFCKIKLLKEERLLLQCLLHV-VPIIELGHDE
INNIIMMSR------LLYYLDSISSLNKKLAID---------------------------------------
---
>YsxEL_Clostridium.spiroforme
---------------------------------MYVSKIIEEAYCLKVIGLIKVSQR--------VYKVKCN
------------------------------EGFFCLKFIENSN----LTVIFDHIESLHLECFLKVIKNVNH
QAIT--------IYEDKMFYLSRWIK---EDNMIVKELKLKFYYECLAYLHSKTFFNYS-------------
------------------------------------------ASKSFFKQQIEDLERIIHERKAYYNELMNN
FETMIYKS-PTGWMFVLNYHKIECCLKNALEILDCY------------------------------------
-RDYVCNLDTIRLCLTYNNFSYAHIMMKE-------------------------------------GKLISF
DHIKINLCIYDIYNMYQK--------IPELIFDFDVILDSYFCKLKLLKEEKLLLRCLLHV-VPIIKLGHDE
INNIIVMSR------LLYYLDSISSLNKKLSID---------------------------------------
---
>YsxEL_Brevibacillus.brevis
-----------------------------MSRYDDIAPLFKEYDMYAQSIDVLKEPN--------VFKATTP
------------------------------YGSFVCKRAQVPA--QRLVFVSDMLRQLQHRGWDGAVPFTYT
KYDD-----PFVQQGSTAYYVTPWQPG-SEEWAEQPLSWAPPALERLAELHHLTQNYRYD------------
-------------------------------------------DPRQVEPLVDSLLNRWRYWQEQMNKAATL
AQERKYPS-PFDLVFLANKEFIEEMAQTATDLLTDW------------------------------------
-RERHETHAHFRLSLIHGNPNPDHVVPDRS----------------------------------GKGRLLNF
DRASFDTPVRDLTLFYRTYFQMAG-----DEVGASQLYHRYAEIFPLQPEEIELMASFLSY--PERIMRDLD
--IYYHHPR---EWSELYAVQRFEKDMDRLMRL---HRWVQQAF----------------------------
---
>BSKC1_C.acetobutylicum
------------------MLDLKSYREKELASYDLDVELFNEF-NFS-VYNVMPLRK--------AFLISTD
------------------------------KGEKILKKIDYTI--EEFKFVLAAVNYIKNENEFNRIIDFNK
TQSG----EYYCIKNGDLYCVMDMIE--GKECEFSNPVDLSISSFGLGQLHSASEGFRYS------------
-------------------------------------------KIASKNICGK-MIKGFKRKKEEVNFLKKM
VNLYESLN-EFDEIFIKNVDYYLEQIDKSIDIMNKS------------------------------------
QYYKLCS-EEDKIVLCHHDLAHHNIIIK-----------------------------------DEEAYFIDF
DYAIIDLKVHDLSNIISK-AAK---VFNYSIDNSKIIISNYCKSNTLSKNEMEVLFGMLSF--PEDFYEIVK
--SYYTKRK---DWSNEEFINKMKRKMANEENR---VEFLKNFKEDLKI-----------------------
---
>BSKC1_C.beijerinckii
------------------MNRTKYSEKNYLCDYDLSLKFFEEL-GIK-VNDIVPLRK--------VFLVYTD
------------------------------EGNKILKRVNYDV--DRVNLISDSLDYVK--KSYEHVITYKR
FKDD----LCYKEWNGQIYIVMDILN--GREASFSNPVEIDLCAENIALMHKASKGLREYL-----------
-----------------------------------------KDKYKKDFLDIS-LKDKIKEAYDDLIWMKSL
VDTYKYKN-EFDKLFVNNVDKYLNEIKEVQNDLEKS------------------------------------
SYDNLRQ-DGDTIRLCHNDLAYHNFLTK-----------------------------------NNEINIIDF
DFMTIDLRVMDIWNFILK-CIK---NAAFDVDKMSTCINGYENVSILKKEEKELLYILIKF--PKDFYTISR
--DYYHKRK---NWEYEVYLSRFEGKLSNEDFR---YEFLKVLENKFFIGAEVKK-----------------
---
>BSKC1_C.botulinum_Eklund
--------------------------------------MFETY-DFK-IEDIIPVRK--------VYILITN
------------------------------KGNKILKKVDCSI--DELNFINSGINYIN-KNSFHRVFNFTK
TKDG----EVYVIWNKNIYCVMDLID--GRESEYSNPLDVMVVSRGLGQLHKACEGFRY-------------
-------------------------------------------KNKIRYLCGT-TIDAFKRKSEELKIFKNV
VKLIKNKT-EFDEIFMDNVDYYIGEIDRAIDVLEKS------------------------------------
NFYKLCS-EEDKIILCHHDLAHHNVLIK-----------------------------------DEEAYFVDF
DYSIIDLKVHDLCNFINK-VEK---RSAYNFDELQFILNNYYKYNNLTKTEMEVLYGMMIF--PQDFYTVAK
--EYYTRSK---DWGYDIFLDKLIKKNGLKQDK---REFLEKFRSDVVKG----------------------
---
>BSKC1_C.botulinum_Eklund_17B
------------------MNRIRYAERKSLCDYDLSFEFFNEL-GIN-INDISPVRN--------VFIIYTD
------------------------------NGNKILKKVDCNE--KKLTLINESLNYIK--DKYNNIITYSE
FENG----SIYKTWKDKTYVVMDLLD--GREACFTNPLEIKLCAENIALMHKASCGIREEL-----------
-----------------------------------------IKKLNEDFLDES-LEIKFKKAYDELSFFKEL
VSKYKYKN-EFDNLFINNVDKYLQDIIDVEELLSKS------------------------------------
KYIDLRK-NGQTISLCHNDLAYHNFLIK-----------------------------------KENVSIIDF
DFLTIDLRIMDIADFILK-SIK---NSAFDIDKMLLAINSYEDVLPLMQEEKEILYILLYF--PRDFYNISR
--DYYYKRK---KWDYEVYLNRFNSKLNNEQFR---KDFIKEYKYYILSEH---------------------
---
>BSKC1_C.botulinum_Langeland
-------------------MDKLN--KNYLKKYNLSSDLFDQY-DFI-IKDIYPIRN--------VYIIDTS
------------------------------KGKKILKKVNYTV--EELKFIEEIIDYIK--IGFKRIMDFEK
NIQG----DIYTIYKGEMYCLMDLID--GRECQFSNPLDLKISSVALAQMHKASKGFTT-------------
-------------------------------------------NFNKRVLNGK-SIEKFKIQKEEMNFFKKI
ANIHKNKN-EFDNLFLSEIDCYIDEISKSINILENS------------------------------------
HYYDICK-ENDKISICHHDLAYHNILIK-----------------------------------EDEAYFIDF
DYAILDLKVNDLCNFITK-VIK---NFAFDINKANIILNSYSSIYSITDKELEVLYGLLSF--PYDFYDISK
--NYYTKRK---DWEDEVFLNRLIKKCNYKEDR---EEFLKNFKDNIL------------------------
---
>BSKC1_C.butyricum_5521
------------------MNRIKYSEKEYLCDYDLSLNFFNAA-GIK-VNDIIPLRK--------VFVLSTD
------------------------------EGNKILKKVNYSV--EKIEFISESLDYLK--KKYKNIISYNK
LKNN----LNYIKWKDDIYIVMDILD--GREASFSNPVEIELCANNIALMHNASKGLIAYL-----------
-----------------------------------------NDKYNKDFIDDS-FKIKIKKALDELEYMKSI
ASRYKYKN-EFDNLFLDNVDKYIDDIKYVEEDLDKS------------------------------------
SYDNLRK-NYDNITICHNDLAYHNFLIK-----------------------------------NSEVSIIDF
DYMTLDLRVCDISDFLLK-AIK---NSAFDMDKMILAIDSYEKSSILMKEEKELIYIYLKF--PKDFYSITR
--DYYFKRK---KWDYDVYLNRLCNKLDNDFFR---QEFMNEYKKIIL------------------------
---
>BSKC1_C.kluyveri
------------------MIDRYSE-KKYLTGYDLCVELFDRF-DLK-VYDVIPIRK--------VYMVSSD
------------------------------KGKKIFKKLEYTL--DELNFINELLTYVR--SKFPRVVNFVE
NKEG----DIYTIWNGDMYCIMDVVY--GRECNFSNPIDLSIAAEGLGEFHLASEGFKT-------------
-------------------------------------------NIKNKYNNGK-LIDIFNRRIQEIEFFQNI
ANIHEKKT-EFDEIFIKNSSYYIEQIKKSESMLEES------------------------------------
YYYKLCS-EEDKIVVCHHDLAYHNILIN-----------------------------------NNEAYFVDF
DYAIIDLKVHDLCNFINK-VVK---NFAFDIEKAKLIIDNYCNKNTLSNRELEVLYAMLNF--PNDFYTISR
--DYYTKRK---DWREEIFLDRLKRKIRYKEDR---EEFLEEFKNKILN-----------------------
---
>BSKC1_C.novyi
--------------------------------------MFEAY-DFK-IEEIIPVRK--------VYILITD
------------------------------KGNKILKKIDYSI--NELNFINSGINYIN-KNSFHRVFNFTK
TKDG----EVYVNWNKNIYCVMDLID--GRESEYSNPLDVMVVSRGLGQLHKACEGFRY-------------
-------------------------------------------KNKTRYLCGT-TIDTFKRKGEELKIFKNV
VKLIKNKT-EFDEIFIENVDYYIGEVDRAIDVLERS------------------------------------
NFYKLCS-EEDKIILCHHDLAHHNVLIK-----------------------------------DEEAHFVDF
DYSIIDLKVHDLCNFINK-VEK---RSAYNFDELHFILNNYYKHNNLTKTEMEVLYGMMIF--PQDFYTVAK
--AYYTRSK---DWSYDVFLDKLIKKNGLKQDK---REFLEKFRTEIIKE----------------------
---
>BSKC1_C.perfringens_13
------------------MNKIRYKDEKYLCRYDLDIKLFEAL-GLD-IFDLRPNRN--------VFLLDTK
------------------------------QGKKILKMINYDD--DRLNFIIHSTEYLR--ERYDGILKINK
LPNG----EWRFKWKGNYYILLDYFE--GTEFNIANPIELEIITDAVAKLHNAGMGIQEAT-----------
-----------------------------------------SKEMNEKNSELFKLKDYFKNSKKDLEKLKEI
VGSYKYKN-EFDEIFIKEVDYHLSDVEKCIDLLEKS------------------------------------
KYDDLCR-DKEKITLCHNDLAYHNILFN-----------------------------------QNKVSFIDF
DYCNINLRVIDLCNFIIK-SIK---RFGFSLEMYDSIIEKYDKLNNLSKEEKELMYIYLRF--PHDFYTVSM
--QYYYKLK---DWKYESFLNKLERKLEYTKEK---EILLNHINN---------------------------
---
>BSKC1_C.sporogenes
-------------------MDKLN--KSYLKKYNLSLDLFDQY-DFI-VKDIYPIRN--------VYIIDTN
------------------------------KGKKILKKVDYTL--EELKFIEEIIDYIK--IQFGRIMEFEK
NIQG----DIYTIYKGEMYCLMDLID--GRECQFSNPLDLKISSAALAKMHKASKGFTT-------------
-------------------------------------------NFNKRVLNGK-SIEKFKIQKEEMNFFKKM
ANIHKNKN-EFDNLFLSEIDYYIDEISKSINILENS------------------------------------
HYYDICK-ENDKISICHHDLAYHNILIK-----------------------------------EDKAYFIDF
DYAILDLKVNDLCNFITK-VIK---NFGFDISKANIILNSYSDVYSITDKELEVLYGLLSF--PYDFYDISK
--NYYTKRK---DWDDEVFLNRLIKKCNYKEDR---KEFLKDFRDNLL------------------------
---
>BSKC1_C.tetani
-------------------MKGIYSTRNYLAQYDLDSTLFENF-KVK-PKEVLPLRS--------VFIISDE
------------------------------TGEKILKKVNYTV--DELEFIKKGLNYVN--RSFNRTINFLE
TKDN----KPYVIWNDSIYCMMNLVE--GRESDYSNPMDLIVATEALAELHYAGKGFYS-------------
-------------------------------------------DIQSKNNLGK-IIKNFKRKEREMELFREL
ALIYNNKS-KFNNIFIENADYLIDKIKKSIKILENS------------------------------------
CYYKLCS-MEEKRVFCHHDLAYHNIIIN-----------------------------------KDKGYFVDF
DYAIVDLRVHDLCNFITK-WVK---SSAYDIEKCSKILEVYNKMNPLNGKEIEVLYGMLTF--PQEIFSIVK
--GYYTENK---NWSEESSIDKLKKKIDLEEFK---EDFLKDFQGFI-------------------------
---
>BSKC2_Anaerocellum_thermophilum
---------------------MYIFMGTP-----ELKLVEENY-YIK-IDEIKQIKSN-------AYFVKTK
D-----------------------------GKEFFLKVSRVAK--DYVDFIIKIFSHLKNTSFKSHLIDFQK
TIDGG---FYFLDENKKVYLLCKWID--GRSADFRNVYDLRRVVSILYHLHLASLSFA--------------
-----------------------------------------EEI---KDSFYPSYQEVFCRKYSQVIQMKNI
IHQKDNLS-YFDEIFLNVLSRFEDRFVESIHMIKKI------------------------------------
EDYFKEENQ---KVLIHHDPAHHNFIFSE----------------------------------KG-VYLIDF
DYAMVDYSVHDFANLGVR-VLK---TNDWDRNMFRIYLKFLQDKNILNKFWLQTFWILMYF--PQEIWQIGL
--QYYFEKQ---PWTEEYFLKRLKGSERIQEEK---EMIIKEFAGGIFKWH---------------------
---
>BSKC2_C.acetobutylicum
-------------------------MNSV----EINEFLKNNY-NIN-AEASQKIKN--------VYRVNSS
------------------------------SKNYCLKCIHYDY--GHVLFIVKAMEHLKENGFD-KIPEIIP
TSSG----EKFIKFRSCYVYLTEWLD--ARVCNFDNPIDLYTAVKALSSLHLKSRSFE--------------
-----------------------------------------VTDNMNPRVGWFNWRENFKRRKDEILKFKKI
ICDKEKKT-EFDNLYMKLMEEELSKADKSIQDIENS------------------------------------
EYVNKMNEEFRLKGFCHHDYAHHNILIDK----------------------------------EGKAHIIDF
DYCMLDTHLHDLSSILIR-KMK---NGLWDMKCCLFILNTYNEDYKIENNDIPIMASFMEF--PQGYWQVGL
--QYYVEKQ---PWTEEFFMSRLNKIYKDKDER---QEFLEDFMKFKYL-----------------------
---
>BSKC2_C.beijerinckii
-------------------------MENNKEILKIKGYIEENY-NLN-VEDIEKVKN--------SYKVITR
------------------------------DERYCLKVVKYEF--SHFYFILSAMKHLQRNGFG-DIPEFIM
NREK----KEYGNINGKYAYLTKWIP--SRVSNYDNPIELSMVSNELAKLHECSKGFT--------------
-----------------------------------------LKKEMKPRIGWFSWIDVFETRRREILDFKNR
ISQKAYKS-NFDLLYLDNMEKELNRAEKSIVGLQKN------------------------------------
NYVKVMEKEVLSRGFCHHDYAHHNILIDN----------------------------------KKNINIIDF
DYCILDSHLHDVSSLLIR-SMK---DGKWESDKCNLILNAYSERIEIRKEELPIIREFIRF--PQAFWQIGL
--QVYWEQQ---PWGEEFFINKLEKYLNDCEFR---EKFIDSYFSGGN------------------------
---
>BSKC2_C.botulinum_A_3502
-------------------------MDKS----EIISIVENNY-NIN-INSIEKIKN--------VYKIISD
S-----------------------------NKTYAFKIIKYEF--NHFLFIISCMKHLQYNNFS-KIPQIIP
NNKG----LDYIKIGDFYGYITEWIEG-SRQCNYSNPVEVMMAANKLGQLHEKSKNFY--------------
-----------------------------------------ITENMKPRIGWFKWPKTFQTRKDEILDFEKR
ILNKNKKS-EFDNFYINILEDEIERADRSIKNLCET------------------------------------
NYLNVMLRQIEDRCFCHHDYANHNILIDS----------------------------------ENQIYIIDF
DYCMLDTKLHDLASILIR-VMK---NGKWDLKSAELILNSYRKESYIDKESIPIIAAFMEF--PQDYWQIGI
--QHYWEKQ---PWSEEFFFNKLNRYHEDREER---QEFIEKFRRINI------------------------
---
>BSKC2_C.botulinum_Eklund
-------------------------METE----ELRNLLQREY-EIN-ITSIEKIKS--------IYRVVAD
------------------------------NKEFCLKVIGYEF--GHFFFILNVIKHLQNNGFC-KIPELIK
NKNG----FDYIKIENKYAYFTPWIK--ARQSNYDNPIDLNMATKKLAELHLKSRGFN--------------
-----------------------------------------VTENMNPRIGWLRWIKTYKTRKNEILDFKSR
INKKYKKS-KFDCMYLGIMDEEIKRADMAIFNLSNS------------------------------------
NYIEKMKKEILYRGFCHHDYAYHNVLIDD----------------------------------KNCVNIIDF
DYCMLDTHLHDLSSLLIR-RMK---YGKWDTKNASEILEIYNSINKVEYDDVAIMAAFMEF--PQDYWQRGI
--QYYWEKK---PWGEEFFIKKLERYIEDREEK---EQFIEDFRNKGIEKL---------------------
---
>BSKC2_C.botulinum_Eklund_17B
-------------------------MRNNDMVLKIKNYIEENY-EIE-VDNLEKVKN--------SYKIISK
------------------------------DKGYSIKIIKYNF--EHFYFILSAIKHLQQNKFS-KIPEFIR
TKNG----KEYISLDGKYAYLTEWIP--SRVSNYDNPLELAKVSNKLAELHECSKNFT--------------
-----------------------------------------INDRMQPRIGWFSWEDVFKTRSNEILDFKNR
ISQKANKS-NFDLLYLKNIDKELKRAEKSIEGLKRN------------------------------------
NYMEIMKKEVFKSGFCHHDYANHNILIDN----------------------------------NNEINIIDF
DYCILDSHLHDLSSLCIR-SMK---YGKWEDKKADLILKNYQDIIELKKEEIPLMREFIRF--PQCFWQLGI
--QVYWEQQ---SWGEEFFINKLNKYLDDCYER---EAFIEDYFKGGD------------------------
---
>BSKC2_C.butyricum_5521
-------------------------MNDSNNTIKIKKFIEENY-DLT-VEKVEKVKN--------SYKVITS
------------------------------HGTYSLKTIKYEF--PHFYFILSAMKHLQENGFT-DMPEFIL
NNRE----KEFGLMDKKYVYLTEWIP--SRLSNFDNPIELSLVATELAKLHKSSCGFN--------------
-----------------------------------------VTEKMKARIGWFSWEEVFETRKNEILDFRNR
IYQKAYKS-DFDLLYLDNINSEIKRAEKSIEGLKKN------------------------------------
NYIKVMEKEIFRRGFCHHDYAHHNILVDN----------------------------------RGKFKIIDF
DYCILDSHLHDVSSLFIR-SMK---DGKWSDRKADVILYSYEKIFEIEKNELPIMREFIRF--PQAFWQIGL
--QVYWEQQ---PWGEEFFLNKLQRYLEDCDER---EEFIDSYFKGGD------------------------
---
>BSKC2_C.kluyveri
-------------------------MDIL----KVREYVEDAY-DLH-IEFIEKIKS--------IYRIHTN
------------------------------CNEYCLKVINYDY--GHFLFIISAIKHLQNKRFR-SIPKIIK
TKDE----KDYIKMENSYAYLCEWII--CRECNYDNPLDILVATSKLGELHKKSYNFQ--------------
-----------------------------------------VTKDMNPRIGWFKWIDTFKHRQEEMINFRKI
ILEKESKS-EFDTLYLNHIDREIELAEKSIDHLKKS------------------------------------
NYMENMKKEIKNMGFCHHDYANHNILIDA----------------------------------KGEVNIIDF
DYCILDTHLHDLSSLLLR-RMK---NGKWNMNNAIFIIDTYSSINDVKEEDIPIMAAFIEF--PQDFWQLGI
--QYYMEEQ---PWGKDFFMKKLKKIFKDKEEK---LEFIDEFRNWKYN-----------------------
---
>BSKC2_C.novyi
-------------------------METE----ELKNLLQREY-GIN-ITSIEKVKS--------IYRIVSD
------------------------------NKEFCLKVIEYEF--GHFFFILNAIKHLQNSGFS-KIPKIIK
TKSG----SDYIKIGNNYAYFTPWIK--ARQSNYDNPIDLNMATKKLAELHLKSRGFN--------------
-----------------------------------------VTESMNPRIGWLTWIKTYKTRKNEILDFRNR
INKRYKKS-KFDCMYLGIMDEELKRADIAISNLIKS------------------------------------
NYIEKMKKEILYRGFCHHDYAYHNVLIDD----------------------------------KNCVNIIDF
DYCMLDTHLHDLSSLLIR-RMK---YGKWDISNASEILEIYNTINKVYSDDIPVMAAFMEF--PQDYWQRGI
--QYYWEEK---PWGEEFFIKKLERYMEDREEK---QQFIEEFRNKGIKGL---------------------
---
>BSKC2_C.perfringens_13
-------------------------MEHD----YIKDKILLNY-GIE-VKEVIKVKN--------TYKIITS
------------------------------DEEYCLKVIKYQY--PHFYFIVSAQKHLMKNGFN-SIPKILD
TIDG----KDYVRLDDKLAYLTPWVK--CRECDYKNKWDLSLAAKKLSELHNSSEGFV--------------
-----------------------------------------INRDLKPRIAWGKWYKIFETRGEEILDFKKR
IYQKAYMS-DFDKLYLSIMDEELKRVERTLSHIKTS------------------------------------
GYFDYMKKEVKKLGFCHHDYANHNVLLLE----------------------------------NNEINIIDF
DYCILDSHLHDLSSLCIR-TMK---EGRWDLNLFKYIIESYSKNKEVRNEEFPIIASFIEF--PQAYWQLGL
--QYYWEQQ---PWEEEHFLKKLGKYEKDREFR---QNFVDELSNFTLR-----------------------
---
>BSKC2_C.sporogenes
--------------------------------------MENNY-DIN-INSIEKIKN--------VYKIISD
S-----------------------------NKAYAFKIIKYEF--NHFLFIISCMKHLQCNNFS-KIPEIIP
NNKG----LDYIKIGDFYGYITEWIDD-SRQCNYSNPVEVMMAANKLGQLHEKSKNFY--------------
-----------------------------------------ITEYMKPRIGWFKWPKTFQTRKDEILDFKKR
ILNKNKKS-EFDNFYISILEDEIERADRSIKNLCET------------------------------------
NYLNVMLKQIEDRCFCHHDYANHNILIDS----------------------------------ENQIYIIDF
DYCMLDTKLHDLASILIR-VMK---NGKWDLKSAELILNSYSEESYIDKEYILIMAAFMEF--PQDYWQIGI
--QYYWEKQ---PWSEEFFFSKLNRYYADREER---QEFIEKFRKINI------------------------
---
>BSKC2_C.tetani
-------------------------MENR----YIKKLVEDKY-NIK-AIHVEKIKN--------VYKIKSN
------------------------------RKNFCLKLLKYRS--QETLFITSAINHLYNNGFK-NTPKIIQ
TVDK----KDCISLGDYYGYLTPWIE--TRHCNYEDPRDVQLAAFTLGQLHKNSINFS--------------
-----------------------------------------WNKYIKSRYRMGRWIQDFNSKKSDISFFKNE
IDKKDKPS-YFDNLFRKVIDEELRRIDKSIYNLERS------------------------------------
DYLNKIQSEKKKNPFCHHDYANHNVLIDK----------------------------------NDSVYIIDF
DYCILDTHLHDLCSLIIR-VMK---NGKWNIENAKKIMDSYSLNYSINKKDIKIMAAFIEF--PQDFWQVGL
--QYYAEKQ---PWKEKVFINKIKRIVDDREAK---QEFVEEFRCINYGSGGCYD-----------------
---
>BSKC2_Caldicellulosiruptor.sacchar
-------------------------MEKI-----NFKLVEENY-SIK-IERIKQIKTN-------AYFIKTK
D-----------------------------KKKYFLKLSRVDK--SRVDFIMDVYSHLKKTSFKSHLIDFER
TIDGG---FYFLDNFGRVCLLCKWID--GRGADYKTFSDLKVIVSILDHLHTSTICFA--------------
-----------------------------------------KQE---DRMHLPCYEEIFQNKYSQIKTMENI
IHQKEVYS-TFDKCFLKTIHRFENRFAECICFVKKI------------------------------------
GSYFRMSNQ---KVLIHHDPAHHNFIFAE----------------------------------DN-VYLIDF
DYAVFDYDVHDFVNLGVR-ILK---TNEWNIDIFKFYLKLLREKGIPKKFWFEVFWILMLF--PQEIWQVGL
--QYYFEKQ---PWTEEYFLKRLKGAIEIQTRK---EMIVNKVVGGKLNWH---------------------
---
>BSKC3_C.acetobutylicum
-----------------MIEKTNPSHI-LLPEDSIKKYILPKY-NLQ-DAEILQIKFKD----TEKQRAVYK
--------------------------LTLGSKKYCLKKVYYDK--GELLFVYSTTEWFFRHGIN--VTRILP
TLDN----SRFVIYSGMIFILMPWID--GLKCNYDKKEDLFKASKNLAHMHKCSQKFF--------------
-----------------------------------------SIQGSSIRYGFEHIYLSNKKHFEQILSFFNK
A--YEIND-SFSKIALNNCDLCIKLSKIALNASSRI------------------------------------
-ESRN-----FKKSLCHLDYVNKNIIFDK----------------------------------NNDIWVIDF
DKCKFDYSVHDISYFMRR-IMKRD-NTRWNSELLINMLNVYEQINPLNLDEYLYILSYLVF--PQKFWKICK
--DYYNNLS---RCNKAAFINLIKSTTKYSELH---LKFAYNFSNYIEGKFNVSLNL---------------
---
>BSKC3_C.beijerinckii
-----------------MGTEVLSLQESNLSPEIIKQNVLPYY-NLQ-NSQISIIKFKD----TDKQRAVYR
--------------------------VNYKDKNYCLKKVYYNL--NDLLYVYSAIEWLYRNNIR--VSKLLP
TIDN----NRFVSYRDMLFILTPWIE--GEKCNFDNLDHVLISVRKLSEIHSVSRKFR--------------
-----------------------------------------PILGSSAKEGFEDYYISTLKHFEDLLKASNE
S--FKYKD-SFSRQFISSFDINLRLAKLSLDISNKI------------------------------------
-DNNE-----LSKSLCHGDYVNKNLIFPP----------------------------------DLDPWVIDF
DKCKVDYSAKDLAYFMRR-LLKRE-NTKWNVELALSILDAYNELCPLTHSDLRYLISYICF--PQKYWRISR
--DYYRNIH---KCNKSAFLTLIINATSKTNLQ---YDFALDIINQVQKKFNMTLL----------------
---
>BSKC3_C.botulinum_A_3502
-----------------MAYAAKSFDIDLLSEENVKKYVLPKY-NLQ-TADICQIKFKN----TEKQRAVYK
--------------------------VTYGNNCYCLKKVYYDE--SDLLFVYSAVEWFYRNGIR--VPRILP
ACDG----NRFVNYNNMFFILTPWIQ--GEKCDYDRTEHIIYSIENLGRMHVSVENFV--------------
-----------------------------------------PIKGSRVKEKKDSIYRSHEKHFFHLLNCSNY
A--FKEKD-KFSDFFLKNFEKNILLARTSVDIAHSI------------------------------------
-NNKN-----LHRCLCHLDYVNKNIILSP----------------------------------NNDIWVIDF
DKCAIDYRVHDIGYFLRR-LLRRK-NTNWDATLAVEILEYYDKFIPLNLDEYKYILSYLSF--PQKFWKISR
--DYYKNIN---KCNKKSFQKILKSSVEDIDNQ---SEFVYLFGKHIESRFGRDLIY---------------
---
>BSKC3_C.botulinum_Eklund
-----------------MADTAKLYNTSIFSEENMKKSVLPYY-NLD-NAEVTAIKFKD----TAKQRAVYR
--------------------------ITTDKKEYCLKKVYFGK--KELLFVYSAIEWLYRHDIN--IPRLLP
NSSC----GRFVEYNNMLFILTPWID--GVKCEYNYEEHITKSCSNLAKIHKRSFDFF--------------
-----------------------------------------PIAGSTYRKGCGNLYKSISKHFDNLLLNSNY
A--FKYRD-YFSKSFLNKFNEGIILAKNSTEALSRV------------------------------------
-NFSN-----LKTSLCHMDYVNKNLIFDK----------------------------------DDNLWIIDL
DKCRIDYCIHDLAYFFRR-LLRRY-ETNWDLDILLLCLDSYEKILPLNVDEYNYLLGYLSF--PQKYWKLSR
--DYYKNIK---KCNKKAFVNMLSKASRDFDKQ---IEFSNKFSAYINKKFN--------------------
---
>BSKC3_C.botulinum_Eklund_17B
-----------------MEPELNLLEKSNLSPDTIKNTVLKHY-NLQ-NAKVDIVKFKD----TAKQRAVYK
--------------------------VEDNNKCYCLKKVYYDL--PDLLYVYSANEWVYRYGIQ--VPKFIP
TVNN----NRFVYYSDMLFILTPWID--GVKCNFDDLNHVILSIKKLANMHLVSTDFQ--------------
-----------------------------------------PILGSSYKVGLDDYYISTLKHFEQLLTISNQ
A--FKYKD-DFSKEFISNFDVNLYLAKLSLDIAYNI------------------------------------
-DNED-----LSTSLCHGDYVNKNIIFTK----------------------------------DLETCIIDF
DKCKVDYCAKDLAYFMRR-LLKRE-NTNWNVNLALSIIKNYNEIFKLTPSDLRYLLAYICF--PQKYWRISR
--DYYRNIS---KCNKTAFLTLLKNTTSKSIAQ---YNFALELLMNIKNEFNILLI----------------
---
>BSKC3_C.butyricum_5521
-----------------MNSEFQALQNSSLSPEAIQRYVLPKF-NLQ-NAQISIIKFKD----TEKQRAVYR
--------------------------VDYNNNSYCLKKVYYEL--DDLLYVYSAIEWLYRNKIR--VPKLLP
TIDN----NRFAQFNDMLFILTPWIE--GEKCSFDNMNHIELSIKKLAQIHSISRTFK--------------
-----------------------------------------PILGSNLKEGFDDYYISTLKHFQDLLKSSND
S--FKYKD-KFSKKFISDFDLNFRLAKISLDMSNKI------------------------------------
-EPSQ-----LSRSLCHGDYVNKNILIPD----------------------------------DNDPWIIDF
DKCKMDYCARDLSYFLRR-LLKRE-NTKWDLDLSLNILKTYNNITPLTESDIYYIISYICF--PQKYWKISR
--DYFKNVH---KCNKNSFFTLLNNASSKSEYQ---YDFAVNII----EKLNL-------------------
---
>BSKC3_C.kluyveri
--------------------------MDLLSEENVKEHVLPKY-NMA-NADITRIKFKD----TNKQRAVYK
--------------------------ISYLNKNYCLKKVYFDE--GNLLFVYSAIEWLFRNNIN--VPRILP
TIHK----ERFVKYNNMLFILTPWID--GIKCDYDNSSHLFSTTLNLAKMHNRSKNFI--------------
-----------------------------------------PIDKSYKRNNFQNIYTSFEKHFRQLLNCSNL
S--FRYQD-KFSKLFLKNFEVNSTLAEIALTVSSNI------------------------------------
-NYNN-----LTTSLCHLDYVNKNIIFDN----------------------------------NNKIWVIDF
DKCSIDYCSHDLSYFLRR-FLKRN-NINWDLNTAIKCLSLYEEVSSLTLDDYKYIISYLSF--PQKFWKISR
--DYYNNIT---KCNMSSFFYLLKKASNNTINQ---LEFTIGLGKYTEKKFNTTIN----------------
---
>BSKC3_C.novyi
-----------------MADTAKLYNSSIFSEENIKKSVLPHY-NLD-DAEVTAIKFKD----TAKQRAVYR
--------------------------ITTDKNEYCLKKVYFQK--KELLFVYSAIEWLYRHDIN--IPRLLP
SSSF----GRFVEYNDMLFILTPWID--GVKCEYNYEEHITKACSNLAKIHKRSFDFF--------------
-----------------------------------------PIPGSTYRKGCGNLHKSMCKHFENLLSNSNH
A--FKYKD-YFSKSFLNKFNEGFILGKNSTEALSKV------------------------------------
-NFKN-----LKTSLCHMDYVNKNLIFDK----------------------------------DDNLWIIDL
DKCRIDYCIHDLAYFFRR-LLRRY-ETNWDLDILLMCLESYEKILPLNVDEYNYLLGYLSF--PQKYWKLSR
--DYYKNIK---KCNKKAFVNMLSKSSRDFDKQ---IDFSYKFANYINKRFN--------------------
---
>BSKC3_C.perfringens_13
-----------------MGKHSKKFNEADEIFNAVESIVLPMY-NLE-NYSIENIKFKN----TDKNRAVYK
LIDD----------------------INNPKNTFCLKKVYYDE--GTLLFIYSVMEWFARNEIK--LPKMLP
SKFN----GRFVKANNMLFMLCPWVK--GEKCNFDNLQHILLSIENLAKMHNCSRNFK--------------
-----------------------------------------AIEGSLIKTGFDSLYISTLKHFNKILSSFNT
ATKMKHKD-KFSSIFLDVFDENIYLAKEALLVSGSI------------------------------------
-NDKN-----LSRSLCHGDYVNKNILIDN-----------------------------------TDVWVIDF
DKASLNYSMYDLCYFMRR-LLKRS-NTNWDIDLTRKILKTYNSIAPLTEDDFKYVFSYLAF--PQKYWRLSK
--DYYNNIK---KCNKSMFVESLKEVSLDTYAQ---VRFVGELRTLFSTEFKIKV-----------------
---
>BSKC3_C.sporogenes
-----------------MAYVAKSFDINLLSEENVKKYVLPKY-NLQ-TADICQIKFKN----TEKQRAVYK
--------------------------VTYGNSCYCLKKVYYDE--ADLLFVYSAVEWFYRNGIK--VPRILP
ACDG----NRFVNYNNMFFILTPWIE--GQKCDYDRKEHIIYSIENLGKMHVSVENFV--------------
-----------------------------------------PIKGSKVKEKNDSIYRSHEKHFFHLLNSSNY
A--FKEKD-KFSDFFLKNFEKNILLAKTSVDIAHSI------------------------------------
-NNKN-----LHRCLCHLDYVNKNIILSP----------------------------------NNDIWVIDF
DKCAIDYRVHDIGYFLRR-LLRRK-NTNWDAKLATEILEYYDKFIPLNLDEYKYILSYLSF--PQKFWKISR
--DYYKNIN---KCNKKSFQKILKSSVEDIDNQ---SKFVYLFGKHIEYKFGENLIC---------------
---
>BSKC3_C.tetani
-----------------MSSITNASDLQLLSEENVRLNVLKHY-NLE-NSIVTQIKFKN----TDKQRAVYK
--------------------------VSHGSKNYCLKKVYFPE--EELLFVYSAIEWMHRYNIK--VPRILP
TLES----NRFVNYENMLFILTPWIE--GCKCDYDNPIHVTRSTENLSLMHHHSSKFF--------------
-----------------------------------------PILGSDNREKFDNVYDTTEKRFNQLLECSNL
A--FKYKD-KFSKYFLSHFDANLNTAKNILALSCTI------------------------------------
-NHNN-----LQKNLCHLDYVNKNIILDN----------------------------------NNNVWVIDF
DKCRIDYRVHDIGYFMRR-YLRRD-NTSWDVKKAIECIEIYEGINPLNLDEHKYILCYIGF--PQKFWKISR
--DYYRNIK---RCNKNSFFKVLTSSIEKEKEQ---DDFVIDFLKYIEDKFNIKLS----------------
---
>BSKC4_Anaerocellum_thermophilum
-------------------------------MIALREEITQFF-DIE-VFYFMPIRD--------ILVLSTD
------------------------------RGLKCFKRVDYSI--ETLLFIHGGKEHLV-SRGFIDIDRFNL
SKEG----LPYVMLGDEIYVLTDWID--ARECELENPIELKAATEKLAMMHEASIGYTN-------------
-----------------------------------------VPEGARVRDDLGKLLTKFEKRCNEFLRMRKM
AEKK--KS-MFDYEYLFTYSYYFDLAKEALEKLKNS------------------------------------
NYLKLCDEAREKRGFIHRDYSYHNILYTH----------------------------------DGDVYIIDF
DYLTYDLRIVDLTSFMQK-VLK---RIHWDIKTGESILNWYSNVSPLNKDELELVYIILLF--PYRYWKTCN
--RYYNGKK---SWSEKAFTNKLHEVIAEKEFH---YDFIRWLEKLI-------------------------
---
>BSKC4_C.acetobutylicum
--------------------------------MMREFEIERQF-NIK-IEYIKPNKG--------VYFVKTN
------------------------------KGNKCLKKINYGI--QKLLFVYAAKEHLI-NNGFKYVDKYCL
NTEG----NPYALVNEDIYTLSEWIE--GRECSFYDTEDLVKASKTLAKMHECSKGYE--------------
-----------------------------------------PPENSKLKSDLGRWPHLIEKRVKALDKMRDM
ARKKGNKK-DFDMNYIKNVDFFKEQGIKSMNVLKNS------------------------------------
KYESLCAVAEEEKGFCHHDYTYHNIIINN----------------------------------EDNVYVIDF
DYCKRELRAYDISNFMIK-VLK---RSNWSMKTAELILDSYSSISKLDDDEYGVIYAFLIF--PQRFWRLAN
--RYYYNEV---NWGQNTFNNKMEELIEERERY---IKFIEDFREAYNLQ----------------------
---
>BSKC4_C.beijerinckii
--------------------------------MMREFEIERQF-NIK-IEKIKANKG--------VYYLKTD
------------------------------KGERCLKKINYGP--QKLLFVYGAKEHLR-KNGFNNLDKYYL
NING----EPYALVNEDLYTLSEWLE--GRECDFHNIDEVKIAAKTLANLHEASKGYD--------------
-----------------------------------------PPENSKLKSDLGRWPHLIEKRIKSLDKMRDM
VRKKSIKS-DFDMLYLKSMEFYKEIGKKSLVTLNES------------------------------------
DYYELCAIAENEKSFCHHDFTYHNIILSD----------------------------------SMDVHVIDF
DYCKREVRTFDISNFMIK-VLK---RVEWNLEFATAIIESYDSVSKLKPEEYKVLYAYLQF--PQRYWRLAN
--RYYYNEV---NWGQNTFAGKLESIIHEQEKY---LEFLEKFKNEYKI-----------------------
---
>BSKC4_C.botulinum_A_3502
--------------------------------MMREFEIERQF-NIK-IEKLKPHRG--------VYHLKTN
------------------------------EGDRCLKKINYGV--QKLLFVSGAKEHLM-KNGFDYVDNYFL
NLNE----EPYALVNEDIYTLSEWIE--GRECNFRDKEDLISAARALAYLHIASKGYE--------------
-----------------------------------------PPENSKLKTDLGRWPNLMKKRVRSLDKMREM
IRKNNNKT-DFDLSYIKNIEFYKELGKRSMKVLEDS------------------------------------
AYMEICKKTEEEKSFCHHDYTYHNIIIDK----------------------------------NDTINVIDF
DYCKREIKTYDISNFMIK-VLK---RVDWNIEYAELILNSYTAINPLKEEEYRTLFAFLLF--PQRFWRLSN
--RYYYNEV---TWPSNTFNKKMEELISEKDKY---INFIEEFKKIYSQKE---------------------
---
>BSKC4_C.botulinum_Eklund
--------------------------------MMREFEIERQF-DIR-IESIKPNKG--------VYFLKTN
------------------------------KGNKCLKRINYGV--QKLWFVYGAKEHLI-NHGFNTVDKYSL
NVDG----DPYAIVNEDIYTLSEWIE--GRECDFHNDDDIKNAAKALAKMHIASKDYD--------------
-----------------------------------------PPENSKLKTDLGRWPHLMEKRVKALDKMRNM
ARKKNRKG-DFDLNYIKTMEFYKKLGIRALNVLNNS------------------------------------
KYMDICAYTEEQKTFCHHDFTYHNIVIDN----------------------------------DNNVNVIDF
DYCKREVRVYDISNFITK-VLK---RRDWNIDCAKIIIDSYNEVSPLAEDEYKVLFAFLLF--PQRFWRLGN
--RYYYNEV---NWATNTFNRKIENLVAEQDEY---MEFIEDFKEVYNQNEDI-------------------
---
>BSKC4_C.botulinum_Eklund_17B
--------------------------------MMREFEIERQF-DIK-IETIKANKG--------VYYLKTN
------------------------------KGERCLKRINYGP--QKLLFVYGAKEHLI-KNGFGDLDRYYL
NVND----EPYALVNEDLYTLSEWLE--GRECDFRNIDEVKIAAKTLACMHEASKGYD--------------
-----------------------------------------PPENSKLKSDLGRWPHLMEKRTKSLDKMKDI
IRKKNIKN-DFDMIYLKSVEFYRELGKQALQTLKES------------------------------------
NYYELCMIAEEEKTFCHHDFTYHNIIIDS----------------------------------NEKPHIIDF
DYCKREVRTFDISNFMIK-VLK---RVDWNIDFAKAIIESYNSVSKLRDDEYKVLFAYLQF--PQRYWRLAN
--RYYYNEV---NWGQNTFTNKLSSIIEEKDKF---LSFLNEFKKEYNIE----------------------
---
>BSKC4_C.butyricum_5521
--------------------------------MMREFEIERQF-NIK-IEKIKANKG--------VYYLKTD
------------------------------KGERCLKKINYGP--QKLLFVYGAKEHLR-KNGFSNLDKYYL
NIDG----EPYALVNEDLYTLSEWLD--GKECDFHNIEEVKIAAKTLANLHEASKGYD--------------
-----------------------------------------PPENSKLKSDLGRWPHLMEKRIKSLDKMRDM
VRKKNIKN-DFDLIYIQSMEFYKEIGKKALQTLKES------------------------------------
DYYELCMAAENEKSFCHHDFTYHNIIIGE----------------------------------NKDVHVIDF
DYCKREVRTFDISNFMIK-VLK---RVEWNFDFAVAIIDTYNSVSKLKDEEYKVLYSYLQF--PQRYWRLAN
--RYYYNEV---NWGQNTFAGKLSSIINEQEKY---LQFLDKFKNHYKL-----------------------
---
>BSKC4_C.cellulolyticum
-------------------------------MNEFERELQLNY-NLK-IKSLTNFRD--------MFLADTD
------------------------------IGKKLIKIASVKR--ERINFIGEVKEHLFNNG-FIHIDRNIP
TVKG----DYSIQFNEQTVYITDYIE--GRECNLESKEETIGCAGLLAKMHRASYGFV--------------
-----------------------------------------CSENSLGRSELGRLPGSYRKRLDEIKKLRKN
AQKG--RM-KFDNLVSKNIDYFYEVGEQALDLLLIS------------------------------------
DYYGLVEEAQKNRTISHHDFNHHNIYIQ-----------------------------------NNEMFLINF
EHCCYDLKVYDLINLLRR-KMR---KCNWDINEAVIILNEYSRYEALSGSDMVLMKIMLMF--PQKFWRVIN
--KYYNSRK---SWSEQSYLLRIQEVIDEAQCH---RVFLEKFSAL--------------------------
---
>BSKC4_C.kluyveri
--------------------------------MMREFEIERQF-NVK-IENIKPSRG--------VYLLKTD
------------------------------KGMKCLKKINYGT--QKLLFVYGAKEHLI-KNGFPHVDKYSI
NIEG----NPYAIINEDIYTLSEWIK--GRECDFKNREDVINAAKCLANMHIASKGYE--------------
-----------------------------------------PPENSKLKTDLGRWHHLMEKRVKALDKMKDM
GRKKNNKG-NFDLNYMKAVKFYKDFGKKAIEVLQDS------------------------------------
KYDELCSITEGEKGFCHHDFTYHNIVVDE----------------------------------DDTFNVIDF
DYCKRELRSYDISSFMIK-VLK---RSNWNIENARLIIDSYNEVSPIKEEEYKVIYAFLLF--PQRFWRLAN
--RYYYNEV---NWPTNTFNKKLEELIAEQEKY---IDFIEKFKEIYSEK-NI-------------------
---
>BSKC4_C.novyi
--------------------------------MMREFEIERQF-DIR-IESIKPNKG--------VYFLKTN
------------------------------KGNKCLKRINYGV--QKLWFVYGAKEHLI-NHGFTTVDKYSL
NVEG----DPYAIVNEDIYTLSEWIE--GRECDFHNDDDIRKAAKALANMHIASKDYD--------------
-----------------------------------------PPENSKLKTDLGRWPHLMEKRVKALDKMRNM
ARKKNRKG-DFDLNYIKTMDFYKKLGIRALNVLNSS------------------------------------
KYMDICAYTEAQKTFCHHDFTYHNIIIDN----------------------------------DDRVNVIDF
DYCKREVRVYDISNFITK-VLK---RRDWNIDCAKIIIDSYNEVSPLNEDEYKVLFAFLLF--PQRFWRLGN
--RYYYNEV---NWATNTFNRKIENLISEQDKY---MKFIEDFKEVYNQKEDI-------------------
---
>BSKC4_C.perfringens_13124
--------------------------------MMREFEIERQF-DIK-IEKLKPNKG--------VYYLKSN
------------------------------KGDRCLKRINYGT--QKLLFVYGAKEHLA-KNGFEHIDRYFL
NIED----EPYALVNEDLYTLSNWIK--GRECDFTNIEEVKLAAKKLAELHEASKGYD--------------
-----------------------------------------PPENSKLKSDLGRWPYLMEKRGKALEKMRGM
ARKKNLKK-DFDIIYIKNVDFYKELAIRATKILNNS------------------------------------
KYLSLCEEAEAEKVFCHHDYTYHNIIIGD----------------------------------DNEVYIIDF
DYCKREIRTYDIANFMKK-VLK---RVDWNIEYAEAIIDAYNTVSPLREEEYEVLYAYLLF--PQRYWRLAN
--RYYYNEV---MWGQNIFINKINNIINEKESY---MKFIEEFKSKYNQVG---------------------
---
>BSKC4_C.sporogenes
--------------------------------MMREFEIERQF-NIK-IEKLKPHRG--------VYHLKTN
------------------------------EGDRCLKKINYGV--QKLLFVSGAKEHLM-KNGFNYVDNYFL
NLNE----EPYALVNEDIYTLSEWIE--GRECNFRDKEDLILAARALAYLHIASKGYE--------------
-----------------------------------------PPENSKLKTDLGRWPNLMKKRVRSLDKMREM
IRKNNNKT-DFDLSYIKNIEFYKELGKRSMKVLEDS------------------------------------
AYMEICKKTEEEKSFCHHDYTYHNIIIDK----------------------------------NNDINVIDF
DYCKREIKTYDISNFMIK-VLK---RVDWNIEYAELILNSYTAINPLKQEEYRTLFAFLLF--PQRFWRLSN
--RYYYNEV---TWPSNTFNKKMEELISEKDKY---INFIEEFKKIYSQKE---------------------
---
>BSKC4_C.tetani
-----------------------------MITMMREFEIERQF-DIK-IEKLKPNKG--------VYFLRTN
------------------------------EGTRCLKKINYGI--QKLLFVYGAKEHLV-KNGFPKVDRYYM
NTYG----EPFAIVNEDIYTLSEWID--GREADFKNKEDVANAAKSLAHMHIASKGYE--------------
-----------------------------------------PPENSKLKTDLWRWPSLMNKRVRALEKMRHM
TRKRNNKN-EFEMNYIKNVQFYKDLGIRAINVLESS------------------------------------
AYEDLCKISEEDKNFCHHDYTYHNIIIDE----------------------------------DDSINVIDF
DYCKREIRAYDISSFMIK-VLK---RVDWDIEYAKLILESYNKEYPLREEEYRVLFAFLLF--PQRFWRLSN
--RYFYNET---NWATKSFDRKMSRLIDEQDAY---MKFIENFKTDYDQKE---------------------
---
>BSKC4_C.thermocellum_ATCC_27405
-------------------------------MQDLDKELSRIY-DFD-IDKIYPLKN--------YYVIETS
------------------------------EGKRILKSVNCSP--ERIMFVHGAKEHLY-SNGFKNIDRYVC
NKSK----SPASFINGILYTVSESVE--GRECDFNNRDDVIRASKTLAMLHKTSKGYI--------------
-----------------------------------------PPQNSIIRSDLGKLPEYFSKRLEEIKRTKKM
AQRE--RN-EFDYLVLEYIDYFYELGENALEKIHNS------------------------------------
KYYDVVKKSQEERLFCHHDYTHCNIICK-----------------------------------DLETSVINF
EHCTFDLKVYDVANLLRR-KMR---KCNWDINEAMVIIDAYTSIEPISKEEFEILEIMLQF--PQKFWRVVN
--RYYNSRR---IKREKNFIARFNEVIEEIEYH---KRFLNEFNKIVQ------------------------
---
>BSKC4_Caldicellulosiruptor.sacchar
-------------------------------MILLREEITQFF-DIE-VFYFMPIRD--------ILVLSTD
------------------------------SGLKCFKKVDYSV--ETLLFIHGGKEHLV-SRGFLDIDRFNL
SKAG----EPYVILNDDIYVLTDWID--ARECELENPIELKAAAEKLALMHEASYGYTD-------------
-----------------------------------------VPQGARIRDDLGKLMTRFEKRCNEFSRMRKM
AEKR--KS-MFDYEYLFTYSYYYELAKEAFEKIKNS------------------------------------
KYSSLCEEARQKRGFIHRDYSYHNILYTQ----------------------------------DGDVYIIDF
DYLTYDLRVVDIASFMQK-VLK---RIHWDIKTGESIINWYSNISPLSKDELELIYIILLF--PYRYWKTCN
--RYYNGKK---SWSEKVFTAKLNEVISERDFH---YDFIKWLEKQI-------------------------
---
>BSKC5_C.acetobutylicum
-----------------MSETEDSIVGIKDKELKMIRKILNRY-EMK-LVDIKKIRS--------IYKIKTE
------------------------------NSTVCLKKVSHEF--KKVENGNYLVRELK-KNNFNNIADYIS
TKDG----KLIVFYKNLAFYLTEWVD--GEECNLNDINEAINASKLLAKFHLATQNIN--------------
-----------------------------------------FHKIKLKNNNSKNWVEIFAKCLRDMESFKSI
IQNKRIKN-KFDFMYEDLIESYYNRGLFSIKILNES------------------------------------
SYFKIIKGSNNKKTVCHNSFYYQNIIKG-----------------------------------KKDYYIIHL
NSIIIDLPITDLCKMIRT-LMTKK-EYMWNFEKAKQIIQAYNSVNKLSKDEMEVMLALIAF--PHKFWKLGK
--KRYVRHK---NWSENKYINKLNKIVLNNKCE---QSFIEEYISYLDDIKEFTNFN---------------
---
>BSKC5_C.botulinum_A_3502
--------------MGNRRVINYDESEITKKERQMINKVLSKY-NFN-VIDFSKVRS--------MYKVETT
------------------------------TGNKCLKRTRHGK--YKIRNGFIFAEELK-NVGFNNIASYYK
TKDD----RNYIKYKKWAFYATEWID--GDECDLNDIVEAENCAKTLAHFHKATQKID--------------
-----------------------------------------INRLKVKS-HLKKWPKRFNKRISDMDRFKNN
IENKKIKN-EFDIIYKEYIDSFYERAMVALSFLNKS------------------------------------
DYYKLSKEAQANKTLCHHSFYYQNIIKK-----------------------------------GREYYIIDL
DNIIIDLQVNDLGKYIRR-LMTKK-SYQWDFEKTKRIIEAYNSENKLTKEDLEVMLSLVIF--PHKFWKLGK
--KRYIKHK---RWPETKYMKKLNKIIKYDDMQ---REFLENYIKYLEQYE---------------------
---
>BSKC5_C.sporogenes
--------------MGNRRVINYDESHITKKERQMINKVLSKY-NFN-VIDFSKVRS--------VYKVETA
------------------------------TGNKCLKRTRHGK--YKIRNGFIFVEELK-NVGFNNVASYYK
SKDN----RNYIKYKKWVFYATEWID--GDECDLNDIVEAENCAKTLAQFHKATQEID--------------
-----------------------------------------INRLEVKS-HLKKWPKRFNKRISDMDRFKNN
IENKKIKN-EFDITYKDYIDSFYERAMVALSFLNKS------------------------------------
DYYKLSKEAEKNKSLCHHSFYYQNIIKK-----------------------------------GKEYYIIDL
DSIIIDLQVNDLGKYIRR-LMTKK-SYQWDFEKAKRIIEAYSSENKLTKQDLEVMLSLIIF--PHKFWKLGK
--KRYIKHK---HWPETRYMKKLNKIIKYDVMQ---REFLESYLKYLEQYE---------------------
---
>BSKC5_C.tetani
-------MVLEVILMRDRNLTNCKR-EITEKEKKFIKKILKNY-ELQ-VLSIERVRS--------VYKVETN
------------------------------CGNICLKEIAKNK--RKPVNGSILVEELD-KHGFPYIAKYFK
TTDD----HLFVKYNKSYYYVTEWIN--GHECNLNDINEARKCMKLMANFHITTFKID--------------
-----------------------------------------GSKLKLRN-NLKNWPKIFFSKLKDIQYFKHI
IKNKRVVT-EFDNLYNSVIDDFYNMGITALHLLNSS------------------------------------
DYYSLSRKANSKRSICHDSIYYQNIIKK-----------------------------------DDDYYLIDL
DSIKIDIHINDLGKVIRR-LMFKK-EYQWDFNKAKELIEAYSSANPLDKADLGAMLSIIVF--PHKFWKLGK
--NRYVKEK---HWSEEKYIKKLNKLIDFDVLQ---QKFIKDYITYVQHYK---------------------
---
>BSKC6_C.acetobutylicum
------------------------------------------------------------------------
------------------------------------------------------------------------
--------------------------------------KAIEQIQIIADFHRIARGYNG-------------
------------------------------------------LDVKTIKNKIGKLVGQYKIHAKKLKKYADM
KKKSSNLT-MFEEYFLNTCESVIERCEKCLGHINDD------------------------------------
EYMEIIKRSMRNNDICLGNCYFENLWKNG------------------------------------NIFLADY
SDIAFNMVEIDGVKFIGK-LKS-----NSLDLNFELLIDKYIEAENIKSESKNLMKALISY--PSEYIKCVE
--RYERNSD---ESLEDRFVKRLAKSIRKDGES-----II--------------------------------
---
>BSKC6_C.beijerinckii
------------------------------------------------------------------------
------------------------------------------------------------------------
--------------------------------------DIVSQVDLIIEFHKLLLGGN--------------
-----------------------------------------LTGLSKIKSTIGREVESYKVQIRKLQKNYSY
VSSKTCTN-EIENIILSNGKIMLEKANKAINYIYEH------------------------------------
DYFGVIRRSMNREEICLGKVDKSNLRKNN-----------------------------------EKIEVCTI
KGMTYNLVEEDLYNYIKK-LQR-----KEINIDEEELIKLFVHGSHLSFNSFDYLRGLCSY--PKDFLKFWE
--RYRDSRK---DNTREIYNIQNEECKGSRKARND-EQLLNGLKKSLKYESKNFII----------------
---
>BSKC6_C.botulinum_A_3502
------------------------------------------------------------------------
------------------------------------------------------------------------
--------------------------------------LVIEQLRIISLFHKNTLGNKS-------------
------------------------------------------YIRGGIKNKTGSIVEKYKLDLKKINKYIRS
LKDKEINNTDLEKLILDYMPNYINRAEKVIENIYEN------------------------------------
GYINLVWRSMDRKEICLGKTYFNNIRYNKG------------------------------------IEVIDI
NKCSYNMVEMDCIELLYK-VNK-----KNSSVDIERLCKIFCEFESLNDESYKFILYMLSY--PYSLIKCCT
--KYMKEKD---SDKEKHYMDRFNKAMKLDSNS-----FV--------------------------------
---
>BSKC6_C.kluyveri
------------------------------------------------------------------------
------------------------------------------------------------------------
---------------------------------------IKEQISIISEFHKRTLGYTG-------------
------------------------------------------VMNKRLDNNIGRVVERYKIYIRKLKKYLEQ
ISSYKNKS-NFEEKLNEVGEGYLIRAERCMENVYKN------------------------------------
NYIDLILRSMSRVEMCLTDIYFDNLRKAK------------------------------------DIQVINI
KNCCYNMVEMDLVYFLNK-IKR-----KGIDINFSELIKSFCIEESLDDNSLQFILSIISY--PYQFMKCCN
--RYRYNTK---NWTEDEYLLRLDKSINEDGES-----LI--------------------------------
---
>BSKC6_C.novyi
------------------------------------------------------------------------
------------------------------------------------------------------------
--------------------------------------EIINQLYIISEFHKKAMGYN--------------
-----------------------------------------DYIGHRLEDKRGRTIEQYKVYIKRVKRKIND
IMHNSPQN-DFEELLLGYGKDYLNRAEKSIKNIYDI------------------------------------
GYLEIMKRSMDRNEICLGNTYFNSLRKIK------------------------------------FIEALNL
EKCFYDLVEIDAATFFRK-LMK-----KNLKLDYKKLVDKFCEFEDLDDRSNVFLQSLIAY--PTEFMKCCN
KYITSTKYM---MYDNRLNINKSKDKLKKIIRC--DYNILCEGGVENFTECKI-------------------
---
>BSKC6_C.perfringens_13
------------------------------------------------------------------------
------------------------------------------------------------------------
--------------------------------------DPLEYLNTLSEIHKEFLKEE--------------
------------------------------------------------NRIKFKFRNDIWKQVQIFKLWSRR
VERLEDSN--------GLINKALDASKKSLDCIYNI------------------------------------
NYKELIRRAMEREEVCIGRIYYEVKNGEK------------------------------------RIFIKNT
EDIKFNMVEEDYYNYLKK-IRGN------YKDELKDLLLEVVEKESLDFKSYVYINSLIQY--PYNSMRYLQ
N-NYIKDLK---IKSNELEELLLKDYLI--------------------------------------------
---
>BSKC6_C.tetani
------------------------------------------------------------------------
------------------------------------------------------------------------
---------------------------------------LEKQLYIINDFHKRIMGYKN-------------
-------------------------------------------IKDRLDSGIGKTVEEYKVYIKKVNRDLKR
IKSEGPRN-AFENKFLEVGEEHIEKGKAAIKNIYKN------------------------------------
DYYSLITRSMQNKEIILDKVDFKHLIKEE-----------------------------------EFIKVKTI
SKCKYNLVEMDCFYLLSR-YKR-----KGVNLNYYMLIDRFCHMENLGQSSYQFILSLLSF--PYEFVKTII
--NYRYDRK---SLSDYEYLVILEKLIEQ-------KDLISI------------------------------
---
>BSKC6L_Anaerocellum_thermophilum
--------------------------------MALKQKFKLHY-GFD-IKELKKFKD--------GYLLKTG
------------------------------KEEYLLKKTKMSP--AEIVFIFHCHQHLKDNRFVNFEKIIPT
KDGC-----PYLRIDKVTYVLIEHFK---KEPVELSEKQVISCIEFINSFHAASTNLKS-------------
------------------------------------------AVGARYNVQYGKDRITARNMYSMFVKLKEK
PQLIKNEK--LRNIILRTIDLNIEYVKKALEILEDD------------------------------------
RYLEVISRSMQENRFIHGKLTIYNIYKCYS-----------------------------------KLRLANM
FNLELNVREKDIATFVKS-LIKI----DKNFDFEECINKFY--VTSYDNYKKCLVLAMILL--PYEYFSLLK
K-IIRFRDL---DWASEEFEEKFTILCEKEQYK---DKILASLH----------------------------
---
>BSKC6L_Caldicellulosiruptor.sacch
--------------------------------MALKNIISLQY-GMN-IKSMKQLQN--------EFLIKTA
------------------------------KAEYIAKKVKLSP--AEIVFIYHCQEHLKENRFVSFEKILPT
KDGC-----PYLRFDKSVYVLIEHFK---KEPIEIVDKEISNCVEFINMFHAASTNLTS-------------
------------------------------------------TVGARYKASYGKDRIAARNMYSVFTKVKQN
PNLIKNDS--LKKVILKTIDKNIEYVEKATKILEDD------------------------------------
RYLDIIGRSMQENRFIHGKLTLQNIVRSY-----------------------------------NKLRLLNM
FDVELNIREKDIATFVKS-LLKR----NKDLDFDEIIGRFY--ITSFDQYRQKLILALLLL--PYEYFSVIK
K-LLKLGNL---EWAFRGFEEKINRICEKDEYK---HKILTSLH----------------------------
---
>BSKC7_Bacteroides.pectinophilus
-------------------------------MNEKALSVIGQY-GLEVRKSVRTRGG---------IAVLTD
------------------------------DGYKLLYECTRSD--SYYERENMITAGIKRTGFEYIDTYVMT
AEGT----LFSQDAQGRKYILKDWFD--AQECDIRNETHVAMAAGTLAVLHGHMMNMDK-------------
------------------------------------------CEHELKYNNATDMRMKFDKHTKEMRMVGNY
LKGKKNKN-EFEMLMRRSLMTFHEEALIAAQELEEMD-----------------------------------
-YGSRIEKARTSYEMCHGSYNYHNVLFTD-----------------------------------RGCAVTGF
EHCCVDCQINDLYQFMRK-LLEK---NGWDARAGHSVIEAYSEVRPVSDDDMKLLRINFLY--PEKFWKVIN
--FYNNSNK---SWIPRKSIEKLEGVLAQNDAR---RAFIETLH----------------------------
---
>BSKC7_Clostridium.hylemonae
----------------------MLYKVQGNVMQEYELNVLDQY-NID-VTGTRKTRG--------AILCDTQ
------------------------------QGLLLLREVTTSE--KRIPALCELYEYLKSQGYEWTDPILLN
KEGE----YVSTAEDGGKYILKQWYQ--GRECDIRKPAELLAAAGNLAKLHTVMCHEL--------------
---------------------------------------------EQGAPAGAHLGEEYIRHNRELKKVRRF
MRGLSPKG-EFEFAFLKYFDQMYQWADLALEELERS------------------------------------
DYDALYEDSMERGCMTHGEYNYHNILILSGAAAAGEAVPASVSGRNAPRGADYRPHGSHSAREPLRIATTNF
DKFKKDIQVEDLYYFLRK-VMEK---HGWKERLGDNMLNAYSAIHPLSSGETEYIKNRLIY--PEKFWKIAD
--SYYHSNK---AWISVKSIEKLNVAIRQTEEK---KRFLENIFSFHL------------------------
---
>BSKC7_Roseburia.intestinalis
------MNKQTLSYDEETRGKTVINHMGGVFLYNRPEQILEQY-ELE-VKSISRGRD--------SYQCDTE
------------------------------QGPKILREYRGSK--ERAGFLADMLDHLSGQGRTVETV-MRT
KEGE----PFSVNEEETKYILYQAFP--GAECDTKNRADMLSAVRELALLHQSAQNYEG-------------
------------------------------------------SVPEFLKSGQNNLLLLYEKRNRELNKVRNY
IRAKKKKN-DFEMMFAVWYPEYVKKAQETTDILKDLG-----------------------------------
-------IQEQLIGFCHGDYNQHNVIFSR-----------------------------------EGIAVVHF
ENFLYQESVGDLANFIRK-MMEK---NNWNAGLGMDLIRGYDRVRKLSPEELKYLYVYLAY--PEKFWKIAN
--RYYNSHK---AWLSGRNIEKLEKVVAQEDAR---EQFLQMLFHFTV------------------------
---
>BSKC7_Anaerostipes.caccae
-------------------------------MNDKYKILLDQY-DLH-VDYLKRGRG--------EIICGTD
------------------------------QGLFALSATKLSE--ERLAVEHQWKEELIDQGFTKIDQYIEN
KEHE----FISYDKYYEPFVMRRTFN--GTECNIHSPSDLSSACRNLASFHRASGRIP--------------
-------------------------------------------YRADYGTPHFSLTKSYHQRRRELKSIWKY
IGSRKNKG-DFEYLFLQEIQPFWKQLEDSSAKMEEL------------------------------------
--------TGLREGWCHGSYNHHNVLMGP-----------------------------------HGTATLHF
EHFYYGYPLTDLYYFIRK-ALEK---NEYQFSICETMLKGYSKVQRLTMNDYSFLYVLFLY--PEKLWKISN
--QYMNHKK---HWVSPRYLNKLQDIVDLKEKR---EKFLLQYHNFYNVF----------------------
---
>BSKC7_C.bolteae
-------------------------------MNEKYVEALEQY-DME-VRAVRKGRG--------SWICETD
------------------------------QGCRLLKEYRGTA--RRLEFEDEVLGRLDTRGSLRADRYLRN
REGG----LMTVTGDGTRYILKDWFL--DRECNIKDGYEIRQALSRLAMLHSQLRKIEFK------------
------------------------------------------EEWNMGSILSGPLEEELERHNREMQRARNY
IRSKRKKT-EFELCVIGSYQMFYDQALEAVQGIRELWPGADELPSEGTGPYNTGKCLKLGPYQEDQDALEAA
EVQPPVKKDRKPLYLCHGDLDQHHVLMGG-----------------------------------NYTAIIEY
NRMHLGIQISDLYRFMRK-VMEK---HGWNLDLGLSMLDSYERVLPMEPKERGCLYYLFLY--PEKYWKQLN
--FYYNANK---AWIPARNTDKLRGLEEQQQAR---NSFLKRLKADCKGCV---------------------
---
>BSKC7_C.L2-50
----------------------MKTIQGGDFLSEKMSEVYEAY-DME-ILGAVRGRG--------SMILKTD
------------------------------QGIRQISPFDGSE--ERLEQEREFKENLYETGFHHIDRCVPN
REGE----LITCDRYGNPYVMREYFE--GRECNPGSICDLNQAAANLAIFHIRGRELY--------------
--------------------------------------------AKEGRTYAYREPGNFRRKTQEMKKIRSF
ISKRPTKN-DFELLYIEAYDAFYRQAIDCQAMMDAC------------------------------------
----DRTNIAGHIGYCHGAYNYHSVLFCG-----------------------------------GYLATVNF
DRFHVGYQLIDLYQFIRK-VMEK---NNYNFNMAVKIIEEYDRILPLTGEDYRYIYILYSY--PEKFWKVSN
--RYMNSRK---CWISPANLEKLSKLITDEQEK---QKFLSDFCNHYGFTS---------------------
---
>BSKC7_C.nexile
-------------------------------MKENEVSVLDQY-DID-IKSTRRIRG--------AILCATN
------------------------------QGLFVLRELMISE--KRIPMLHKLYVHMMENGCDRVDAVIEN
KEHEL----FSTSEDGIKYVVKRWYD--GKECDIRKEQEIVGATKNLAKLHKVLRGPIDFG-----------
------------------------------------------EESETFVMEGEDLRKEYCRHNREMKKVRAF
IRGKVGKG-EFELMFLKYFDAMYDWAQSASARLEQS------------------------------------
EYELLMQQSREKTTITHGEYNYHNVLMMQ-----------------------------------DGIATTNF
EHFHQDVQLADLYYFLRK-TMEK---NHWNVMLGDKMLEAYSEILPLGEREMEYLAISLSY--PEKFWKAAN
--SYYRSSK---AWIPMKSVEKLEVAIHQTEEK---KHFLEAIFSFHL------------------------
---
>BSKC7_C.phytofermentans
-------------------------------MEDRSQEVLGKY-DLR-IYNTYRTRG--------AYVLETD
------------------------------QGLKLLCGYEGGE--GRLEFEDTIKQQIAANGYENTDGYVRN
CAGS----ILSVNSIGEKFVIKNWYD--GEECNLKKEDKICLATSNLARLHNCMVGIEVS------------
-------------------------------------------SEQKQCYQQGNLFTILEKRTRELKRVKSY
IRERKQKN-EFEVCYLSECEQFYQDALYAMEYMKQI------------------------------------
PYCTLMCNSLDRGMICHGNYTYHNVFILNLNKAA------------------NQLCSAAEVHESDMVATSNF
EKAVLGLQITDLYQFIRK-VMEK---NDWNISMGQNILKEYQKQRTLSKAEKHLLYVLLLY--PEKFWKITN
--YYYNNKK---SWIPQKNVQKLITLTDQIDSK---KEFLDQLLKA--------------------------
---
>BSKC7_C.scindens
-------------------------------MQEYELGVLEQY-NIE-VISTRKTRG--------AILCDTD
------------------------------QGLLLLKEVRVSE--KRIPALFELYEYLYSQGYGRIDRIILT
REGE----CLSALEDGSRYMLKSWFK--GRECDVKKPAELLAASGNLAKLHILMCHELG-------------
----------------------------------------------SNVTAGAHLKDEYLRHNRELKKVRKF
MRGIAPKG-EFEFAFLKHFDQIYQWADAAIAELENS------------------------------------
DYESLYQDSVKNCCMTHGEYNYHNILMVQG--------------------------DYNYKKEPYRIATTNF
EKFKRDVQVEDLYYFLRK-VMEK---HGWKERLGDNMINAYSAIRPITDAELEYLKVRLIY--PEKFWKIAN
--SYYHSNK---AWISIKSIEKLNTSIKQTEEK---RRFLEDIFSFHL------------------------
---
>BSKC7_C.sp.SS2
VYPIYTFMASFYHIPSLIFISLEVEHKGGSMLNEKYQALLDQY-DIS-VSHTRRGRG--------CVLCFGE
------------------------------NDVYALSQTSLSE--ERLCAVSEWTLAMHDHHFYKTDQYILN
KDGY----FLTFDRYYETFALRKTYL--GTECDIHALKDIRSSAENLASFHNHCLAIS--------------
-------------------------------------------FSSENLRKYTSISTYYEQKYLELKSIARY
IRKRKKKG-VFEYLFLEQTKAFWEQMERSIQILNET------------------------------------
--------IPSRRGWCHGAYNHHNIIMTS-----------------------------------SAPATIHF
EHFYHGYPILDVYYFLKK-TLEK---NNYNFAFCETFLSNYDRFMPLSKDDLLCLYGLFLF--PEKFWKISN
--QYMAHKK---HWISPRYIEKLEEFIHNKEAR---SIFLEKYVQIYNVFS---------------------
---
>BSKC7_Coprococcus.eutactus
-----------------------------------MGEVYEAY-DME-VQGIGRGRG--------AIILMTD
------------------------------KGIRQVAALNGTD--ERLLQEKQFKDSIYEKGFCYIDRVVPN
SDEE----LVTCDRYGNPFVCREYFQ--GRECSASNIRDLEKAVINLAQFHKAGRELYE-------------
---------------------------------------------DEGSREYDKMPGNLDRKLRELRRIRNF
VSRRNKKN-DFEIQYIRAFDYFYRQADRCLKLFEEN------------------------------------
-----FKCNEKWIGYCHGSYNYHSVMFCDG-----------------------------------YIATTNF
DRFHVGYQLVDLYQFMRK-AMEK---NRYDIEMARDILSAYSQIRHLDKEDYEFIYLMYSF--PEKFWKISN
--RYMNSRK---SYISPVLMEKLQKVIEDDQEK---LKILSEINDTYGLHKLTN------------------
---
>BSKC7_Dorea.formicigenerans
------------------------------MQDYERDNILEQY-EIA-VNSTRKTRG--------AILCSTD
------------------------------KGVFLMREVGVSE--KRLPALIELYEYFMDYGYQTIDMPVKN
REGD----YVTKGFDGSIYMLRRMPP--GRECDVRRAAELFEAAGNLAKIHLLMRKKI--------------
---------------------------------------------MENVSEAENLEEGYIRHNRELRKVRAY
IRNVSPKG-EFEYLFLEYFDQMEAWADAAVKSLKAS------------------------------------
GYKQLYQQSIDAGYMVHGEYNYHNILFDATS------------------------EKDNYGHRKLNVYTVNF
DHFKKNVQVEDLYYFLRK-AMEK---QGFKEWISDGILNAYSAIIPLGKNELEYLKNRLMY--PEKFFKVAN
--SYYHSNK---AWISIKNVEKMQMAVRQMKEK---EHFLNHFFDARI------------------------
---
>BSKC7_Dorea.longicatena
-------------------------------MQEFEQKILEQY-DIE-VSSTRKVRG--------AVLCETN
------------------------------KGLFLLKEITTSE--KRIPALCELYTRLYEQGYHRIDYVVTN
RNGE----YISALDNGDRYILKKCFA--GRECDIKKTREIFEAAGNLAKLHIIMRYEL--------------
---------------------------------------------EHGIPEGTKTDEKYRRHNRELKKVRQF
TRKVVPKG-EFEFAFLKQFDQMYQWAEAAVEELERS------------------------------------
DYEKLYAEEMKKSGMIHGEYNYHNIIMTK-----------------------------------EGIATTNF
EKFRRDIQVEDLYYFLRK-VLEK---SGWKIRLGDGMLNAYSAIHPLTEGEMEYLKIRLIY--PEKFWKTAN
--SYYCTNK---AWISVKNIEKLQTAIRQTEEK---KMFLKEVFGFEL------------------------
---
>BSKC7_Epulopiscium.sp
-------------------------------MRNIPKDLLNEY-DLE-VYRSQYNRN--------NFILDTN
------------------------------KGKYILRKVNTQH--EQIIFMYEAINHLYKNGFTQTEIIYPT
KKNL-----PYVTLTGQTYILQSHKN--SLEIEFKNTEDIIAIIKLLANFHKCGLNLKT-------------
------------------------------------------SVHDASPIHMKDVYSYFTKRIKETNTLKKA
IQPLSQKT-EFEAMFLKDYKDYLDLENLALMCINEN------------------------------------
SCTSLIKHATTNRTLAHNEYKYHSVGKTN-----------------------------------SQLYLLNI
DKCGINMQIQDLSSILSK-IMQK---NSWDIEFLKILLTEYENIRPLSIDERAVLKALLIF--PEKFASMCN
N--YLQCKR---RNNYSMFLVKWENMLVYKEKQ---LAASKYIKENL-------------------------
---
>BSKC7_Eubacterium.ventriosum
-------------------------------MNERALTVFEQY-ELD-ITETFKIRG--------NYGCNTP
------------------------------DGKYILQEYDNSN--DKMVSMKSLYNHLESSGIKTDYVIPNK
EDRY-----VSVSEDGYTYILKKWFE--SQECNINEEKHIVMGAANLGRFHTLCQNSQR-------------
-----------------------------------------FMEETKGFHPGKNMLVIYEKHNKEIINIRNY
IKKRKNKN-YFELALKEMLVEYYSQADEALKALRQTG-----------------------------------
-YGKMYNNALEHKNLNHGSYNHHNIVLLN-----------------------------------GKIAMINM
SKINYAPAIQDVYDYLRK-VMEK---NNWNIDLGRKVLAEYESKKIINQEEHNILKIMFSY--PEKFWKIIN
--YYFNSNK---AWYSEKNEEKLKQLQNQEEIR---KKFIENM-----------------------------
---
>BSKC7_Ruminococcus.gnavus
----------------MNPPCFRRGKVQGASMREYELEVLEQY-DIE-VISTRKTRG--------AYFCNTK
------------------------------EGLMLLGPAGISV--GRAPLMYVLLCYLESRHGMKVDTPIFT
KAGK----LFSVSQDGTKYMLKKWVS--GRECEVRRERDVLEAAQALGLLHQRMDWGEILGDG---------
----------------------AWTKEKMQEMIPQASDHEPVLEIELKPFAGRDMLSELRRHNRELKKVRAF
IRSRVTKN-EFERRFLAHFERMYEMAQSVTERMECS------------------------------------
GYPELYKDNLKAGKLIHGDYNYHNIWISS-----------------------------------GRIAVTNF
EHFRMDVQVQDLYYFLRK-VMEK---YQWKESLGRKILEMYESVRPLEDREKEFLALCLAY--PEKFWKTAN
--LYSNSNK---ARIPEKSVEKLQTAIGQQAEK---ERFLENIFTFHL------------------------
---
>BSKC7_Ruminococcus.lactaris
-------------------------------MREYEQEVREQY-EIE-IKSTRRTRG--------AFFCVGN
----------------------------ADTEVFLMKETLASE--KRAALLYLTLNRLEKTGKLKVDAPVFS
RDGK----LIVAARDGTRYMMKKWYS--GRECDMKKEQELLLAAEKLGILHTHLKWQEPTAGELETLLCKYA
VRSEDAAVSESGAVSENAAVSGNGAVSEKKEKEPVPQQQFPEEEFQVCPPAARSPLDEMLRHNREMKKVRSF
IRKRVVKN-EFEALYLKHFEAMYEKACAITAAMEQS------------------------------------
GCMQIYEKNVAENRMMHGDYNYHNILILP-----------------------------------GDTAITNF
EHMRIGIQVQDLYYFLRK-AMEK---YRWKQKLGVGIIRAYERQRRLEPGEWEYLGLQLAY--PEKFWKTAS
--SYCRSNK---AWLPEKSVEKLELAVNQEEEK---TNFLKTIFGIHL------------------------
---
>BSKC7_Ruminococcus.obeum
------------------------------------------------------------------------
------------------------------------------------------------------------
------------------------------------------------------------------------
-----------------------------------------MHIPTVEYYIEPSLENGYLRHNQELKKIRSF
IRKRGASS-PFEKIYLATVEDFLRDGEEAYAALRES------------------------------------
GYQELRQKAETEGEVCHGEYNQHNVLILK-----------------------------------SGTAVTNF
EHWGFDTQMADLYRFMRK-ILEK---YNWDVRFGKEMLKAYHEIKPVSKEEWKNLKIRFSY--PEKYWKLAN
--YYYTHRK---TWISVKNTEKLQNLIRQREAW---KRYCASFFF---------------------------
---
>BSKC7_Ruminococcus.torques
------------------------------MREEYELEVLEKY-DIE-VKSTRRIRG--------AFFCIGS
ELKSGRVGDFGDCLQSRSVPFGAAGDYDTKERPMLLKETKLSE--RRALFLYDALSEIERCGNVKVDTPVFT
KEGE----LRAASREGAFYMLKKWYQ--GRECDVRQEQDVVRAAAKLAVLHKDMEKLAVK------------
-------------------------------------------IRPGADAQGKNPVEEVRRYNRELKKIRSF
IRSRPVKN-DFEILFLENFEKMYRTADDILARMETS------------------------------------
GCRKLFEESVSKGSVVHGDYNYHNLIMLR-----------------------------------DDIAVTDF
EHMHTDIQIKDFCYFLRK-AMEK---NQWKQKTGQKILEAYEEVRPLSEREKEFAALSLAY--PGKFKKIAG
--SYYRSNK---AHLSEKNVEKLQICIRQTEEK---YEFLSRIFPLNL------------------------
---
>BSKH1_Heliobacterium.modesticaldu
-------------------------MKTVYGIMGIDPRVLLAY-RMR-PRRIEPVRG--------AYRIEDT
------------------------------GGVWVLKRFPHAV--EDLQFIFRAQHHLAARGFRRFSPIRLT
PQGA-----LCLSVGSEHWLCSAWVE--GRECDFDRWRDLAATAAAVAEFHYAGRGFIASEFAG--------
------------------------------------RCLWQRWPQIIATKTAQLEACRRVAVERMEQRVHAG
GEEPDDST-EFDRLFLTHADTLLAEAREACALLDHS------------------------------------
AYSMLMEREAAGGGLCHHDLAHHNVIIDD----------------------------------EGQIFFLDF
DHAVMDTRLHDVGSLLIR-ALK---RDRWSVEKGVNLLSAYHDAYPLSQAEREVLVAFLSF--PNDFWQYVY
--AYYFESL---AQPPEYHIKRLKRFLNHQKQR---RRFLNEFPGRL-------------------------
---
>BSKH2_Heliobacterium.modesticaldu
---------------------------MAETAEQLVELIRREY-GLH-VRAIQRLTP--------VWRLETD
------------------------------IGPLCLKRVGYDE--GKLGFICAAMEHLRRQGFTRSPVLLPS
REGRL---DYRDTGRDGWLFLTDWVAD--RPCNFSEEAHILAAAATLAEFHQYAKGLT--------------
-----------------------------------------SPDLSRRRGHWMRWPRLLAGRTADLHRYETL
GARAPIER--------ELLKTQIRQAQRALAVLERS------------------------------------
EFGRIAAASQMEKTFVHRDIAARNFVLNYR----------------------------------DEAHLIDF
DYCRCDLHLVDIARLLER-VLR---YHRWSYSLGQKILSVYEETTPLQPSEYPVLLAFLLF--PQRFWRLYR
R-RYDGFIS---DASEFSRDLRQLQAEQRQKGF-----FLRRFAEEYCWGFLHRHGFDCIVEAETFLNEEGL
LAE
>BSKH3_Heliobacterium.modesticaldu
---------------MASILAPALRKGEMTMRDGQESPKLSKW-DMD-ALQEYPYTVTAADRQGNFWRLETN
------------------------------RGIKAFYRHEEKA--DRVAETHAMLEHLAERGFRRASRFIRT
RDGR-----PFAQRGPYTYVLTDWLP--GRSTDFQRDDDLRQAARTLAAIHWSGAGFH--------------
------------------------------------------GGGEKDAQKVSRLLKTLADRREALQWYRQL
AQMKRQTS-EVDRLLKEWGPEFEQKATRALRRVADT------------------------------------
---MVKPSGEAGWTICHRDWREGNLHLDG-----------------------------------ARLAVTGW
DSCGPDLPAAELAQFLRR-VADA--RGRWDVESGMQIIDAYRETGNLGTGDRELLVGLLEF--PQRFWSLVA
G--HYRGAG---EPSTPELLRREIAEEAGR------QDFVASLERHLGTGN---------------------
---
>BSKH4_Heliobacterium.modesticaldu
LGNAMTVGNDAFFRNEPALSGNASLAPDLRAERETLVDLLAEY-DLT-LRSLHR------------------
------------------------------QGGRFLAETDRGP--LRVEFLEGEKALQRGRNITAALKHLRE
KGFTQ---ERVIPWGDRAYYLYNKLP--GRSAKLDASRDLQEAGRSLALLHRGGRGFQ--------------
-------------------------------------------PVEPSVAAPLDIPGQFAWGRQVAADWLAT
VGRQRFFS-DSDHLLRENLPKLTERGEKGFAWMEAA------------------------------------
-YQEKRRQTEQEGALCHGDYGAASLLKTQ-----------------------------------QTFWVDRF
NHCRCDIPVTELAQFISN-IVR-SSRDGW--KEAIYVVEGYESVEKLNEADWRILLGCLII--PFDLFEHLE
G-KIRTEPA---NTIEIIPDRKLQDQGFRRTRRT-IETCNRAYAAAYRLAAQAELALPI-------------
---
>BSKA1_Alicyclobacillus.acidocaldarius_LAA1
------------------------------MDAGEFADLVRRAYGIEADAIVQKRT---------VWGIVAG
------------------------------TSRYILKRARPQDSEERLRGLADILSCYPRLGVAAARPLETV
YGTMR-----VSGGSGAWYYLQPWLE--GRHVDASDEAERLAVTRALARAQRAAPRGA--------------
---------------------------------------------ALRALRTVTLRDKWRAKLELLERLQAI
P---------VEAEIAESLRRIAARARAVYASYLDEAR----------------------------------
----------RPLAFCHRDLAPHNVLVGPG----------------------------------GSVMFIDF
DHAGYDDPFSDPIQWVSHVAYLVP----LCPSAYRRLWLTYAQAAELDEAELVSLVRLGAW--PDIALRALA
--EAFRGGQ------PGSRMWRLRYALRCEEDR---ARLHDAWLRELEA-----------------------
---
>BSKA2_Alicyclobacillus.acidocaldarius_LAA1
HLLAELLSPPAFLPSQTSLAAPPSESGRHPAPNAVSPAATVAERPPREADEMRGSGRTAEDTERPNSRSQAP
PIPQSVVSKYDLAIQQRHADGNIEVWTDGKGRRYAAKRSSITP--DHCRTMYQCLRHAQEQGFTKFARFVTT
SSNAP-----YVRHGDFTYYVTEWVS--GQPANFGLPEHVAQTAYTLAQFHEATRSFR--------------
-------------------------------------------TDWKPDEAADDVFGLFQARSRDLRHMWLR
ADRKKEKD-AFDQLLLSMREDLYRDAAESLALLEDR------------------------------------
DVIAYLEAERSSGGWCHLDVIPSNCLYTAQ----------------------------------HQVVLIDF
ELARPAPRALDMAHLLRRSLERG----NWDGHLAYACFLHFDAVRSIPKAEYRAVEAILRF--PYLPWRIAH
ARYHFGADP--------SQLDALQRYAMQEEKR---QAFLASLRQQVEHLGE--------------------
---
>BSKA1_Alicyclobacillus.acidocaldarius_DSM_446
-----------------------------------MADLVRRAYGIEADAIVHKRT---------VWGIVAG
------------------------------TSRYILKRARPQDSEERLRALADVLSHYPRLGVAAARPLETV
RGTMR-----VSDGRGVWYYLQPWLE--GRHVDASDESERLAVTRALARAQRAAPAKG--------------
---------------------------------------------ALLALQTATLRDKWRAKLQLLERLKAI
P---------VEAEIAESLHRIAARARAVYASYLDEAR----------------------------------
----------RPLAFCHRDLAPHNVLVGPG----------------------------------GSVMFIDF
DHAGYDDPFSDPIQWVSHVAYLVP----LCSGAYRRLWLAYAQAAELDEAELVSLVRLGAW--PDIALRALA
--EAFRGAQ------SASRMWRLRYALRCEEDR---ARLHDAWLRELEA-----------------------
---
>BSKA2_Alicyclobacillus.acidocaldarius_DSM_446
HLLAELLAPPAFLSSQPSPDAPPSESRRHPAPNAVSPAATVAERPPREADEMRGSRRTAEDAARLGSRSQAP
LIPQAVVSKYDLAIQQRHADGNIEVWTDSKGRRYAAKRSSIAP--AHCRIMVQCLRHAQEQGFTKFARFVTT
SSNAP-----YVRHGDFTYYVTEWVS--GQPANFGLPEHVAQTAYTLAQFHEATRSFR--------------
-------------------------------------------TDWKPDEAADDVFGLFQARWRDLRQMWLG
ADRKREKD-AFDQLLLSMRDELHRDAAESLALFEDR------------------------------------
DVIAYLEAERSSGGWCHLDVIPSNCLYTP----------------------------------QHQVVLIDF
ELARPAPRALDMAHLLRRSLERG----NWDGHLAYACFLHFDAVRNIPKSEYRAVEAILRF--PYLPWRIAH
ARYHFAADP--------SQLDALQQYAVQAEKR---QAFLASLRQQVEHLGE--------------------
---
>BSKB1_Brevibacillus.brevis
------------------------------MNKGILSTIEKAF--RCQIYGVKPKRN--------VNLLKTD
------------------------------RGHWILKGYKQVE---KAVWVTELADALYQKGFHHTVQYVES
QEGA-----KIFTFEDRHYTIMKMID--GHEADNGSLFDVKKTAETLARFHVAAQGFP--------------
------------------------------------------IAHSYAYEGKPALLDKWESRLEYFERLMWS
LEQKGPQT-KLEQLISQQADHVLRDGKELLQSAYKLP-----------------------------------
-LTPEMFLAMERGTLAHRDVASHNFLLTER----------------------------------GNCYLIDL
DTVGHDLQLVDLVQLMSRMLLMQ----EYRMDSFVEAMEAYSNVNYLSDTQIWAVHQLLRY--PDNFLREVT
--GLYSQRP---GYHMKGVMQLIQMEGKVMANR---QRFLNDGERIFQRSPWGHYHFVG-------------
---
>HSK2_pdb_2PPQ
------------------------MAVYTDITEDELRNFLTQY-DVGSLTSYKGIAEG---VENSNFLLHTT
------------------------------KDPLILTLYEKRVEKNDLPFFLGLMQHLAA-KGLSCPLPLPR
KDGE-----LLGELSGRPAALISFLE--GMWLRKPEAKHCREVGKALAAMHLASEGFE--------------
-----------------------------------------I-----KRPN-ALSVDGWKVLWDKSEERA--
-----------DEVEKGLREEIRPEIDYLAAH----------------------------------------
WPKDLP------AGVIHADLFQDNVFFL------------------------------GDE----LSGLIDF
YFACNDLLAYDVSICLNAWCFEK--DGAYNVTKGKALLEGYQSVRPLSEAELEALPLLSRGSALRFFLTRLY
-DWLTTPAGAL-VVKKD-PLEYLRKLRFHRT-I---ANVAEYGLAGE-------------------------
---
>gi|13425070|AAK25326
------------------------MAVYTDITDQELEAFLEGY-DLGAPLAFKGIAEG---VENSNFLLETE
------------------------------KGRYILTVYERRVKAEDLPYFLNMLTWLAD-RGYPSARPIPT
RSGA-----TLSSLRGKPAAIVEFLP--GLSVRKPTAAHCREAGEGLAWLHLAGEGYP--------------
-----------------------------------------G-----RRAN-DLGQAAWSPLFSKHRKAA--
-----------EDLKPGLSATIDNDLAQLSLM----------------------------------------
WPRNLP------TGTIHADYFPDNVFFQ-----------------------------SNGK----FAAAIDF
YFACDDAYAYDVAVTLNAWCFEA--DGSFNITAAKALLNGYERRRPLSPIEKEALPILARGAAMRFFLTRLA
-DWGSTPAGAL-VRPKD-PLEYERKLAVHRE-G---LVLFA-------------------------------
---
>gi|13476235|NP_107805
------------------------MAVYTDVAEGELGAFLKHY-PVGDLLSYKGIAEG---TENSNFLLHTS
------------------------------SGSYILTLYEKRVEKADLPFFLGLMGHLAN-KGVSCPLPVTA
HDGS-----VIGTLAGRPAVIITFLE--GLSLRRPTATHCAEVGKALAALHLAGADFP--------------
-----------------------------------------M-----TRPN-ALAIDGWRKLWNAARDRA--
-----------DEVEPGLAAEVDADFADFERN----------------------------------------
WPRGLP------AGIIHADLFPDNVFFL------------------------------GEK----LSGLIDF
YFACDDLYAYDVATCLNAWCFEK--DFSFNLTKGKALLAGYQSVRPLSGEEKAALPMLSRGSALRFMLTRLY
-DWLTVSDGGL-VMKRD-PTEYIRRMRFHRA-I---KSASEYGLA---------------------------
---
>gi|15073844|CAC45485
------------------------MAVYTDITEDELIRFLAAY-EVGSLTSYKGIAEG---VENSNFLLHTT
------------------------------KGAYILTLYEKRVNADDLPFFLGLMHHLAE-RGLSCPLPLPR
ADGK-----LLGTLSGRPAAVISFLE--GMWLRKPEAQHCREVGRALASMHQAGEGFP--------------
-----------------------------------------L-----KRPN-ALSVEGWRPLWRNSEARA--
-----------DEVQAGLKDEIATELAFIEEH----------------------------------------
WPKDLP------EGVIHADLFPDNVFFL------------------------------GDR----LSGLIDF
YFACNDFLAYDVAICLNSWCFEK--DGSYNITKGMALLSGYESVRRLTAEEIEALPLLARGSALRFFLTRLY
-DWLMTPPGAL-VVKKD-PLEYLTKIRFHRA-I---VSSAEYGLRREEAPA---------------------
---
>gi|17429253|CAD15940
------------------------MAVFTPVTNAEIALWLEQY-DVGTVRALRGIPSG---IENTNFFLTTE
------------------------------KDEYVVTLFE-RLTSEQLPFYLYLMQHLAQ-HGICVPAPIPG
RDGA-----ILRPLKGKPATIVTRLP--GRSNLAPTTSECAIVGDMLARMHLAGRDYP--------------
-----------------------------------------R-----HQPN-LRSLP-W---WNEVVPDIQ-
-----------PFVQGATRELLVAELAHQQRFFG-----------------------------------SAD
YA-ALP------EGPCHCDLFRDNVLFE----------------------------PATDSQPERLGGFFDF
YFAGVDKWLFDVAVTVNDWCVDL--ATALDAERMRAMLRAYHAVRPFTDAEARHWRDMLRAAAYRFWVSRLW
-DFHLPRDAEL-LQPHD-PTHFERVLRERVR-A---EGLTLDIPEPCN------------------------
---
>gi|19714489|AAL95118
------------------------MGVFINLFQDEIDFIEEKY-KI-KILEIKNIDNG---ILNSNFYVKAK
------------------------------NKKYILRIYEANRTIDEEKQELILLDKIAN-F-IPVSKAIRN
IDNE-----YISILNNKKFALFEYVD--GNSITKIDTYIIREIAMNLGKFHSFSKEIS--------------
-----------------------------------------F-----EKYN-RKTRIDFNFYYNEIKKSKI-
-----------DFKFKRELLNLADEINSYDFS----------------------------------------
---TLP------SGIIHGDIFPDNVLLD-----------------------------EYNN----IKVIFDF
NESYYAPFIFDIAIVINFWIRIK--DFDFENNFIRDFFNYYSKYRKITKEELKLLDIACKKTALTFIFLRIE
-KIENSYQKAISIEEKS-YLDLIKLIDEYEK-----------------------------------------
---
>gi|23010066|ZP_00050886
------------------------MAVYTDVSDEALRAFLSEY-DLGELVSYKGIAEG---VENSNFFLQTG
------------------------------TGTYILTLYEKRVSEADLPFFINLMGHLAR-AGLACPLPVRN
RAGT-----ALGRLCGRPAAIVTFLK--GVSLSHPSAEHCRALGAALAGLHAAGRDFP--------------
-----------------------------------------M-----VREN-NLSVAAWRPLFAQAEAQA--
-----------DTVAPGLAARTRADLDLLEAA----------------------------------------
WPQGLP------SGVIHADLFTDNVFFI------------------------------GDA----VSGLIDF
YFACTDAFAYDLAISLNAWCFDA--DGTFHRNKAGAMIAGYDAVRKLEPAEIAALPVLARGAAMRFMLTRLV
-DWLNVPPGAW----------CSRRF----------------------------------------------
---
>gi|23347272|AAN29419
------------------------MAVYTDINEIELGAFLRHY-DIGTLTSYKGIAEG---VENSNYLLHTS
------------------------------SGSFILTLYEKRTNREDLPFFLGLMQHLAK-RGLECPQPVVR
NDGA-----MIGQLAGRPAAIVTFLE--GMWMRRPTVAHCEAVGEGLAHMHLAGADFP--------------
-----------------------------------------M-----RRRN-GLTLPDWRPLWNLSRKCA--
-----------DTVERGLVAETEADLDFLEKN----------------------------------------
WPADLP------QGVIHADLFPDNAFFL------------------------------GDR----LSGFIDF
YFACTDILAYDVAVCLNAWCFEK--DFSYNRTKGAALLRGYTSVRPLSEAEADALPVLARGAAVRFMLTRLY
-DWLTVPAGSF-VVKKD-PMEYVRRMRFHRQ-I---ESAAEYGLEMQGVAA---------------------
---
>gi|24981467|AAN65755
------------------------MSVFTPVTRPELETFLAPY-ELGRLLDFQGIAAG---TENSNFFVSLE
------------------------------QGEFVLTLIE-RGPSEDMPFFIELLDTLHG-ADMPVPYAIRD
RDGN-----GLRELCGKPALLQPRLS--GKHIKAPNNQHCAQVGELLAHIHLATREHI--------------
-----------------------------------------I-----ERRT-DRGLD-W---MLASGAELL-
-----------PRLTAEQAALLQPALDEISAH----------------------------------------
KALALP------RANLHADLFRDNVMFE------------------------------GTH----LTGVIDF
YNACSGPMLYDIAITVNDWCLDE--QGAVDVPRAQALLAAYAALRPFTAAEAELWPEMLRVGCVRFWLSRL-
-IAAESFAGMD-VMIHD-PSEFEVRLAQRQQ-V---ALHLPFAL----------------------------
---
>gi|27376426|NP_767955
------------------------MAVYTDVAADELADFLSQY-DLGELLSYKGIAEG---VENSNFLLHTT
------------------------------KGSFILTLYEKRVAKNDLPFFLALMTHLAE-HGVNCPLPVKG
RDGE-----ALRELSGRPAAIITFLE--GVWPRKPNAAHCAGVGEGLARMHLAGANFA--------------
-----------------------------------------I-----RRAN-ALSVAGWRPLFDAAASRA--
-----------DEVQPGLRAFLAAELDYLASG---------------------------------------V
WPTNLP------EGVIHADLFNDNVFFL------------------------------GDK----LSGIIDF
TFACNDMLAYDVAICLNAWCFEP--DHSFNVTKARAFLNAYGRVRKLSEAEEAALPLLARGAAIRFLLTRLV
-DWLNVPPGAL-VRPKD-PLEYVRKLRFHQS-V---SSVRDYGLMPSGLVA---------------------
---
>gi|30249442|NP_841512
------------------------MSVFTPVTKEQLAVWLKNY-SLGSLIDLQGISSG---IENTNYLVTTT
------------------------------QDKFILTLFE-KLTSTELPFYLNLMAHLSE-QSIPCPRPVES
QNHR-----LLGQLNGKPACIVTFLP--GRSMVQVAEKQCAQVGEMLARMHLAGRNYS--------------
-----------------------------------------G-----WNQN-PRGLN-W---WQTTAETVM-
-----------PFLSSSEQNLLDEELQFQAAQ---------------------------------------M
TA-NLP------QSVIHADLFRDNVLFT------------------------------SDG----IGGVIDF
YFACNDTLLYDLAITANDWCTLT--DGIMDKTRMHALVTAYHAVRPLTADEHSAWPAMLRAGALRFWLSRLY
-DYYLPRPGEL-THKKD-PGHFKRILEHHLS-N---PGVLPSFQA---------------------------
---
>gi|32043065|ZP_00140327
------------------------MSVFTPLERSTLEAFLAPY-DLGRLRDFRGIAEG---SENSNFFVSLE
------------------------------HGEFVLTLVE-RGPVQDLPFFIELLDVLHE-DGLPVPYALRT
RDGE-----ALRRLEGKPALLQPRLA--GRHERQPNAHHCQEVGDLLGHLHAATRGRI--------------
-----------------------------------------L-----ERPS-DRGLP-W---MLEQGANLA-
-----------PRLPEQARALLAPALAEIAAL-------------------------------------DAE
RP-ALP------RANLHADLFRDNVLFD------------------------------GPH----LAGLIDF
YNACSGWMLYDLAITLNDWCSNA--DGSLDPARARALLAAYANRRPFTALEAEHWPSMLRVACVRFWLSRL-
-IAAEAFAGQD-VLIHD-PAEFEMRLAQRQN-V---EIHLPFAL----------------------------
---
>gi|33596532|NP_884175
------------------------MAVFTSVSDQDARTLLARF-DLGDLVSLRGITAG---IENTNFFLNTT
------------------------------RGEYVLTLFE-VLTQEQLPFYIELMYHLAA-RGIPVPQPQTL
RDGT-----RLTTLHGKPCAIVTRLP--GGYEPAPGPDHCRLAGATLARAHLAGQDFP--------------
-----------------------------------------L-----RQPN-LRGLP-W---WQATAPKVL-
-----------PFLEPGQARLLEAELADQQAHAA-----------------------------------TAL
WQ-SLP------SGPAHCDLFRDNVLFA------------------------------GTFDDPLMGGFIDF
YFAGCDTWLFDVAVSVNDWCIVR--DTEFVPELVHGWLQAYAEVRPFTDAERQAWPVMLRAAALRFWLSRLY
-DFYLPRPAQT-LKPHD-PRHFERVLQARHR-H---PAPDLPKSEAAA------------------------
---
>gi|34102085|AAQ58452
------------------------MSVYTTVSRESLQHWLQGY-ALGQLLELKGIAAG---ITNTNYFVTTT
------------------------------HGRYVLTLFE-TLHLDELPYYLTLMSHLAK-HGVACPAPVAD
HTDR-----FASTLAGKPACLVSCLG--GQDVSHPSAEQCRAVGETLAQMHKAGATFP--------------
-----------------------------------------L-----QMKN-PRGPR-W---WSRTAQQLY-
-----------PQLPADQAELLREEIQFQDSH---------------------------------------R
FD-HLP------SGVIHADLFRDNVLLN------------------------------GNH----ISGFIDF
YYACNDILLYDVAIAVNDWARLD--DGELDGGLAKAFLEGYQSERPLEAAERDCWPVMLRAAALRFWVSRLQ
-DLYQPASGEL-TYTKD-PAVFQNLLLGHRL-R---QDFWLD------------------------------
---
>gi|39937330|NP_949606
------------------------MAVYTDVAADELADFLSRY-DIGDLLSYKGIAEG---VENSNFLLHTS
------------------------------RGYFILTLYEKRVARDDLPFFLSLMTHLAD-SGINCPQPVAD
REGR-----TLATLAGRPAAIISFLD--GVWPRKPSVVHCAGVGQALAKMHLAGRDFA--------------
-----------------------------------------M-----KRAN-ALSVAGWRPLFAAAEARA--
-----------DEVQPGLRDFLAAELSYLESG---------------------------------------V
WPSDLP------QGLIHADLFPDNVFFI------------------------------GDE----VSGIIDF
TFACNDLLAYDVAICLNAWCFEA--DHAFNVTKARALLSAYTRERPLDAAEQAALPLLARGAALRFLLTRLV
-DWLNVPEGAL-VKPKD-PMEYVRKLRFQQN-V---AGIRDYGVEIAGAVA---------------------
---
>gi|47572521|ZP_00242564
------------------------MAVFTEVGFDEAAALAHKV-GLGPLKALKPIKAG---IENTNYFLTAE
------------------------------RGEYVLTLFE-RLSAEQLPFYLHLMKHLAG-RDILVPMPQSD
AHGE-----ILHALCGKPAAIVERLR--GGHVLAPSAAHCQQVGAMLARMHEAGRDYP--------------
-----------------------------------------Y-----HQPN-LRGLA-W---WDETVPQIL-
-----------TFLAPPQRALLEDELAFQHSV--------------------------------------SA
SAAALP------RGPIHADLFRDNVMFDEDA-------------------------EGRSQ----LTGFFDF
YFAGVDRLAFDIAVCLNDWCIDL--ASRLLEDRAAAFVTAYAEVRQLTGDELRLLPALLRAAALRFWISRLW
-DVHLPREASM-LVPHD-PTHFERVLRERIA-T---PWHPASR-----------------------------
---
>gi|48733055|ZP_00266798
------------------------MSVFTPLARPELETFLAPY-GLGRLLDFQGIAAG---SENTNFFISME
------------------------------KGEFVLTLVE-RGPVQEMPFFIDLLDVLHE-ADLPVPYALRT
TDGV-----ALRELKGKPALLQPRLA--GKHIKQANAQHCAQVGDLQAHLHLATQDNM--------------
-----------------------------------------I-----KRKT-DRGLD-W---MLEEGTQFL-
-----------SHLSDEPRALLQKALDEITQQ----------------------------------------
RELALP------RANIHADLFRDNAMFE------------------------------GTH----LTGLIDF
YNACSGPMLYDVAIALNDWCSDD--NGLIDGPRARAFLGAYAALRPFTAAEAELWPTMLRVACVRFWLSRL-
-IAAESFAGQD-VLIHD-PKEFEQRLAQRQT-V---STPLPFAL----------------------------
---
>gi|48766095|ZP_00270645
------------------------MAVYTDVSDDDLTTFLEGY-DIGRLRACKGIAEG---VENSNFLLVTD
------------------------------RGPHILTLYEKRVNPDDLPFFLGLLRHLAA-RDIPCPQPVAG
RDGA-----VLHTLCDRPAAIVTFLD--GVWPKRPEVRHCAQLGEALARLHLAGGDYA--------------
-----------------------------------------P-----TRRN-SLSVDGWRPLFDAAAERA--
-----------DSVKPGLRAELETELDALEAL----------------------------------------
WPHDLP------TGIIHADLFPDNVFFV------------------------------DDT----LSGLIDF
YFACDDFLAYDLAVCLNAWCFEG--EREFNVTKARHMLTRYEKVRPLSDAEFAALPLLARGAAMRFLLTRLY
-DWLNTPPGAM-VRPKD-PMEYYHKLAFHRA-V---SGPGAYGLSR--------------------------
---
>gi|48851216|ZP_00305458
------------------------MAVYTQIGAEDMAALVAEF-DVGELVSAKGIAEG---VSNSNWLLDTT
GRDGK-------------------------GARFILTMYEFRIELEDLPYFLSLLDHLAG-RGCAVPRTIHD
RAGA-----LYRMRGDKALALIEFLP--GVSVSEPTPAQARAVGTALAQMHLASADFA--------------
-----------------------------------------G-----SREN-GMGLAEWQRLFDACGAEGL-
-----------ARIDPDLAGLVAEHMPRIAAQ----------------------------------------
WPADLP------RSVIHADLFPDNVLML------------------------------GDK----VTGLIDF
YFACNDIMAYDVAVTHAAWCFDG--SGSFDPAVSAALLEGYESVRPLLPEERAALPLLAQGAAMRFTSSRAY
-DWLNTPADAL-VVRKD-PMAFARRLQFYAA-N---PAIFDTNAFA--------------------------
---
>gi|49475239|YP_033280
------------------------MAVHTDIHPNDLKAFLTRY-SIGSLLSYQGIVEG---IENSNFMLYTT
------------------------------EGKFILTLYEQRISKDDLPFFCNLMQHLGR-RGVPCPQPVIQ
NNGM-----MIGELAGRPAAIITFLE--GEWVRQSNIYHCCEVGCSLAQLHLAAQDFS--------------
-----------------------------------------L-----SRRN-TLSLVDWKCLWKRCQVRK--
-----------DPLLREFGKKIDTELAFLEEN----------------------------------------
WPSILP------TGIIHADLFNDNVFFL------------------------------NDR----LSGIIDF
YFACNDFWAYDLAICLNAWCFEH--DHSYNLIKARGLLESYQKIRPLVPLELNAIVLLARGAALRFLLTRLY
-DWFNTPPGSV-VVKKD-PWEYWHKLCFFSN-V---GSLSELGF----------------------------
---
>gi|50086377|YP_047887
------------------------MSVYTPLSLQEVQAFALPY-GL-EVIDLIPIQGG---IENTNYFLVAN
N-----------------------------QQQYVLTVFE-ELDEQGASELPPVLQHLGQ-AHVPVAVPL-N
YEGK-----FIHRIAQKPAQIAPRIA--GEHPIPSNIAQVKSIAAAQASLHLALQNYS--------------
-----------------------------------------L-----ARSN-SRNHQFW----TAVGESLK-
-----------PVMSTEDLNLLNQVYVQFNQL----------------------------------------
REPDLP------CGWIHSDMFRDNTLFV------------------------------GDE----LEGILDF
SELNQDDFLFDIAISINDFCTEY--PEAYDHDKLQAFVDAYQSVRSLTQDEHTCLPIYLAMAACRFWLMRLR
-NAQEGRIGDD-IMQKN-PLEMRNMLVDRLQ-A---MAK---------------------------------
---
>gi|56477689|YP_159278
------------------------MSVFTPVSTEELSPWLGRY-AVGRLVGLQGISAG---VQNSNFFVTTT
------------------------------LGRYVLTLFE-GIPRAELPFYLHLMAHLAR-HGLPVPAPIAD
RDNE-----YLGTLSGRPAALVRRLS--GHSEMTPGADHCARVGAMLAGLHLAGLSYG--------------
-----------------------------------------R-----RQDN-PRGAA-W---RDVAAARVR-
-----------PFLPADEQALLDAELAFQEGV---------------------------------------A
DD-RLP------QGVIHADLFRDNVLWD------------------------------DGL----IGGVIDF
YFAGHDALLFDVAVTVNDWCTTP--GGELDPSRAEALLAAYHAERPFEAAERDAWPAMLRGAALRFWLSRAE
-DFHLPKAGEM-VLVKP-PAEYRDILRRHIA-A---PHSLPV------------------------------
---
>gi|56544070|AAV90224
------------------------MAVYTSVSDEEVSSFLDLYPDSGRLLSIKGITEG---VENSNYLITTD
------------------------------VRSYILTLYEKRVNPEELPFFMALTDHLAA-ENLPVPKAWKS
RDGK-----QIQTLAGRPACLIEFLQ--GRWTPTPNAEQTRATGEMLGKMHKSLTHFS--------------
-----------------------------------------E-----NRKN-SLDLENWHILAEKCGFEAM-
-----------NQIEAHMGDEVKKELDYLDKF----------------------------------------
WPKDLP------RSVIHADLFPDNVLFE------------------------------GDS----LKGVIDF
YFACTEVRAWDLAITYSAWCFDQ--EDHFLADHAKALIKGYHQSFALTEEERAAFIVLLRGAALRFLLTRAW
-DWVNTPPDAL-VVPKD-PRDFFKRLRFYRE-A---SLESLGF-----------------------------
---
>gi|58038660|YP_190624
------------------------MAVYTELAAETLEAFLGTY-DIGTLVSFHGIAEG---VENSNFLLRTT
------------------------------EGDFILTLFERRVNARELPWFLGLMQYLAG-RGLNCPLPVSD
RSGT-----ALRSLADRPAAITTFLP--GVSATQLDANLCLELGKVLARLHIAGEGYD--------------
-----------------------------------------A-----VRPN-ALSPAAWGPLLDSCGESG--
-----------DELSPGLTAEVRKALQNVEAA----------------------------------------
WPADLP------RGQIHADLFPDNVFFQ------------------------------NGQ----VSGLIDF
YFACTDFLAYDLAICLNAWCFRD--EKTFEPSFAAAIMQGYESVRPLSDAEKAALPTLCQGAAIRFLLTRLY
-DWINTPADAL-VTRKD-PLAYLRRLRHFQS-A---SHV---------------------------------
---
>gi|61102021|ZP_00377475
------------------------MAVYTHLSAEDLARLIGHY-DVGKLVSAKGIAEG---ISNSNWLVETT
GSDGN-------------------------GARFILTMYERRIDLSDLPFFLGLLDHLSA-KGVPVPRTIHD
RDGA-----SSRMVDDKAVALIEYLP--GVSVGHPTPEQARAVGIALADLHLASTDFA--------------
-----------------------------------------L-----TREN-DLRPRDWAAILADAGAGAI-
-----------GTIDRALPSVIEESLSDLLEH----------------------------------------
WPEDLP------SSIVHADLFPDNVLML------------------------------GSR----VSALIDF
YFSCHDITAYDLAVTHVAWSFTA--GGDYRTEVGAALLEGYQSVRPLSQSEIAALPLLAQGAAMRFIATRIQ
-DWLDTPADAL-VTRKD-PMDFARRLQFYRR-D---GEKVFNA-----------------------------
---
>gi|66857339|ZP_00401391
------------------------MALYTVLSSEQIADAIRSF-GLPAPDRVQPEPKG---SVNTNYHLWTG
------------------------------GERWFLRLNE-GKTDADVRFEAEVQRYLHE-ARFPVARLRLA
ADGR-----PWVPVEGKQAMLFAYAA--GEEISRAGPERCRRVGEQLGRLHELASGFV--------------
-----------------------------------------P-----ERRN-PYAPERVRGWISELRPDGG-
-----------GDADRAALPMLDDELARADRL----------------------------------------
-P-GAP------RGLVHGDLFIDNVLWI------------------------------GDR----VGAVLDW
EMSCVDPFAYDLGVAVNAWCYVD----RYDPARAAALLAGYRSRRRLEPETADALYPWARYAALRFTASRIH
-AFHRAALGADRLAWKD-WRRYRDRLAALRD-M---GEGGFRALLGV-------------------------
---
>gi|67153489|ZP_00415234
------------------------MSVFTPLERHELETFVAPY-GLGRLLDFQGIAEG---SENSNFFVTLE
------------------------------QGEYVLTLVE-RGQMDDLPFFIELLDVLHA-ADLPVPYALRT
GDGL-----ALRKLAGKPALLQPRLS--GRHVQEPNAQHCREVGTLLARLHLATCKSP--------------
-----------------------------------------L-----PRPS-DRGLE-W---MLEKGPELA-
-----------LQLPDEQLPLLREALAEVARL----------------------------------------
KSLALP------TANLHADLFRDNALFD------------------------------GPH----LTGVIDF
YNAFAGPMLYDLAIAVNDWCSKE--DGSLDPQLTQAMLAAYSAKRPFRAAEAELWPAMLRIACLRFWLSRL-
-IAAQAFAGQQ-VLIHD-PEVFRRRLQARRH-V---QVALPFAL----------------------------
---
>gi|67665008|ZP_00462276
------------------------MAVFTAVSDSDLAQWMRHY-ELGDVLAFRGIPSG---IENSNFFLTTT
------------------------------RGEYVLTIFE-KLTAQQLPFYLDLMRHLAA-HGVPVPDPIPR
DDGA-----LFGELHGKPAAIVTKLD--GAAELAPGVEHCIEVGQMLARLHLAGRDYP--------------
-----------------------------------------R-----NQPN-LRSLP-W---WQENVPAIV-
-----------PFITDAQRALLEGELAHQAGFFA-----------------------------------SDD
YA-ALP------AGPCHCDLFRDNVLFAHAA-------------------------PGTGH-DVRLGGFFDF
YFAGCDKWLFDVAVTVNDWCVDL--ATVLDVARADALLRAYQTVRPFTAEERRHWSDMLRAGAYRFWVSRLY
-DFYLPRAAEM-LKPHD-PGHFERILRERIA-H---TPALPEIQTACN------------------------
---
>gi|67676179|ZP_00472930
------------------------MAVFTPLTETQVASFLERF-DVGALRALEGVPSG---TENSTFFVTTD
------------------------------RDRFVLTLFE-QGESDELPFFVALLDYLAE-HRLPVPGPVHD
RDGV-----ALQQLAERPALLFPRLP--GRHPEAPTLAQCHALGDALGRMHKVSQRFE--------------
-----------------------------------------G-----QRPN-PRDLH-W---LASAQHKVM-
-----------SYLAADDQRLMGDEIDAYQVA----------------------------------------
FGSPLP------QGAIHGDLFRDNTLFD------------------------------GDR----LGGIIDF
YNGCTGDLLFDLAIVVNDWASDA--DGHLDRERYTALLAAYQARRPLTATERELWPMMLRMTALRYWLSRLL
-VVYVDPPAHD-LTPKD-PGEYRRLLLTRLA-H---GAPPLPAPVSST------------------------
---
>gi|67911229|ZP_00509606
------------------------MAVFTEVSFDEAAAFLNAL-NLGQLQSIKGAAGG---IENTNYFVDTD
------------------------------QGHYVLTLFE-RLTFEQLPYYLHLMKHLAA-RGIPVPDPAEN
GKGE-----ILHRLKGKPTAVVNKLR--GHSELAPTPAHCAAVGEMLARMHLAGLDYP--------------
-----------------------------------------R-----QQPN-LRGLA-W---WNETVPVVL-
-----------PHLTPEQRSLILGELAYQNHV--------------------------------------TD
SSRSLP------RGAVHADLFRDNVMFE------------------------------DGK----LTGFFDF
YFAGCDTFLFDIGVCLNDWCIDL--DSAQDSARADAFVAAYQSVRRLTAQERTLLPAMQRAGALRFWISRLW
-DFHLPREAAV-LKAHD-PGHFERVLRQRLT-D---PYAL--------------------------------
---
>gi|68191236|EAN05893
------------------------MAVYTDISEEELTAFLRHY-PVGKLLSYKGIAEG---TENSNYLLHTT
------------------------------AGAYILTLYERRVDRSDLPFFLGLMEHLAR-KGVSCPLPVKR
LDDG-----LIGELAGRPAALITFLE--GMWMRRPTALHCGQVGKALADLHQAAEDFP--------------
-----------------------------------------L-----KRPN-ALGPEGWRRLWEGAKARA--
-----------DEVEPGLAREVDAEFALLERD----------------------------------------
WPKDLP------SGVIHADLFPDNVFFL------------------------------GGE----LSGLIDF
YFACNDLLAYDLATCLNAWCFEK--DISYNLTKGAALLAGYQAVRPLTREEIEMLPLLARGSALRFMLTRLY
-DWLTIPDGAL-VKKRD-PLEYLRRLRFHRQ-V---RTASEYGIELA-------------------------
---
>gi|68213440|ZP_00565272
------------------------MSVFTTVSFEQMQQWLKGY-DLGELLDLQGIASG---ITNTNYFVTTD
------------------------------NGRYVLTLFE-EHSAEELPNFLDLMTHLAE-RGIPCPHPVKN
NAGR-----ALGELNGKPAALVSCLA--GRSLDNPMPQHCAAIGEVLARMHIAGASFK--------------
-----------------------------------------A-----GMSN-LRGQE-W---RIATAAKVA-
-----------PFLDEENHRMLDAQLEFERTF---------------------------------------D
TR-RLP------RGVIHADLFRDNVLMD------------------------------GDK----VGGVIDF
YYACHDALLYDIAIAVNDWCVNA--DCTLDAVRVRAFLDAYHAIRPLTGEEHAAWPGMLRVAAMRFWLSRLN
-DLYFPQAGEL-THAKD-PAYFERILKHSIA-A---REQILAVWVNAH------------------------
---
>gi|68247351|EAN29437
------------------------MSVYTTLTLAELGPFLARH-DIGQPLSLEGISAG---VVNTNYRLTTS
------------------------------RGIYILTLIE-SGERDYLPWMLALLAHYRE-RGVPCPLPIAD
NRRQ-----MLHTLKNRPAILVSFLD--GELPNPLTPGHAWQAGRLLARLHHGAQSFD--------------
-----------------------------------------Y-----PREN-PLGPVAWRSILAQLTPMLQ-
-----------EDVT--TLELLQKTLIESETV----------------------------------------
LFKTLP------SGIGHADLFPDNTLFD------------------------------GEV----LTGAIDF
HYACTLPWIYDLAISLCAWGFDE--EGAPRPKMMSELWRGYAEARPIDPDELQIVPVAMRAAALRFSLTRLR
-DFHFPRQGLQ-VTRKN-PAAFLRLLHWLWE-N---PSIIKQLGHP--------------------------
---
>gi|68538785|ZP_00578561
------------------------MAVYTHVEPDDLAALVAQY-DIGTVVSCKGIAEG---VENSNFLLETT
------------------------------RGRFILTLYEKRVSEGDLPFFVELLDHLAK-RGCPVPAMIRD
REGR-----AIQQVSERAACIIQFLP--GISLTHPTPGQCQAAGAAMGAMHRAVADFA--------------
-----------------------------------------G-----AREN-SMGHRHWRAIAQGAGD--L-
-----------DAVIPGLQAIVDEELDHLDAH----------------------------------------
WPRDLP------AHVVHADLFPDNVLML------------------------------GER----VTGLIDF
YFAASDFRAYDVAVTHASWTFST--DGDCDIGRASALMRGYAREVALTDEEFAALPLLARGAALRFLLTRAH
-DWIHTPPGAL-VTRKD-PAPFLARLRRYQA-A---DAAALFSAA---------------------------
---
>gi|69930059|ZP_00626936
------------------------MAVYTDVAADELADFLKAY-DIGELLSYKGIAEG---VENSNYLLHTT
------------------------------AGSFFLTLYEKRVAVDDLPFFLGLMGHLAT-HGIVCPQPVKA
RNGE-----ALGCLAGRPAAIIDFLE--GVWPRKPNVTHCAAVGAALAKLHLAGRDFP--------------
-----------------------------------------M-----RRAN-ALSVSSWRPLFEQATPCI--
-----------DTVQHGLHDFLKAELDHLERH----------------------------------------
WPQNLP------AGVIHADLFPDNVLFL------------------------------GDR----LSGLIDF
YFACNDFFAYDVAICLNAWCFEP--DHSFNVTKARALLGAYNRERALSEAEQAALPLLARGAALRFLLTRLV
-DFLNVPAGAL-VKPKD-PLEYVRKLRFQQS-V---GNIREYGVAASGLVA---------------------
---
>gi|71039606|AAZ19914
------------------------MSVYTQLTDDQFSAFCQRF-GV-SFACAIPITQG---IKNSNWFIQTT
DDVDG-------------------------AHSYVFTLFE-ERPLEDIEKMAVILNQLDG-K-LPVAAPLSL
VDSAEKC--YVIRYDNKAITLVPCLA--GSHPQQTTQAMCHEIGTALAMLHETLQALQ--------------
-----------------------------------------P-----SEQY-GVPLYPW----SDVRDRER-
-----------QFMPADEAKLMSDIWQSYTDL----------------------------------------
--ATLP------KGLCHLDMFADNTLWNLSL-------------------------NNSQKGEESLTGLLDF
TEVSVEHYVMDIAITINDFCTTW--GDNFDRSKMAAFLQGYESKRSLGADEKRALPVMLAKAAVIFWLLRLY
-NRTEGRTGDN-IMVKN-PDLMKRLAAYHWS-H---VEKAKNTVFVLLDNL---------------------
---
>gi|71082833|YP_265552
------------------------MAVYTKLIKKDISSLINNY-QINKIEKFQGIKKG---IENTNYLLKTK
------------------------------QNKFILTIFEKRVKKKDLPFFMNLMEKLNH-KKIICPKPLRT
KKGT-----HITNIKTKSACIVTFLE--GKDKTILNNKNCFDVGKNIAKFHKVTTKLK--------------
-----------------------------------------L-----YRQN-SMSIHRLNGLLKTIKFKS--
-----------NQITPNLKNTLNLCLKDIKNK----------------------------------------
WPKNLP------QGIIHGDLFIDNIFFN------------------------------KNK----FSGFIDF
YFSSNDYLIYEIAICINALCFDK--KKKFNSSKIKNLINGYESIRTLSKKEKDALNVMCRGAALRYLLTRIY
-DYFNTPKTAL-IKIKD-PIEYLQKLIIHNN-L---GHYKDYYK----------------------------
---
>gi|71736460|YP_272566
------------------------MSVFTPLARPELEAFLAPY-GLGRLLDYQGIAAG---SENTNYFISLE
------------------------------QGEFVLTLVE-RGPVQEMPFFIELLDVLHD-ADLPVPYALRT
TDGE-----ALRQLADKPALLQPRLP--GKHISEPNTQHCVQIGELLANLHLATREQV--------------
-----------------------------------------L-----ERKT-DRGLD-W---MLSEGRNFL-
-----------SHLGETQRALLEKSLQEIEDF----------------------------------------
KPMALP------RANLHADLFRDNVLFE------------------------------GTH----LTGLIDF
YNACSGPMLYDLAIALNDWCSRE--NGQLDAVRARALLGAYAGLRPFTAAESKLWTTMLRIACVRFWLSRL-
-IAAETFAGQD-VLIHD-PAEFERRLAERQE-A---HIALPFAL----------------------------
---
>gi|71905808|YP_283395
------------------------MSVYTKVGRDELAAWLQPL-GLGELIDHAGIAAG---MQNSNYFVTTT
------------------------------SGRFVLTLFE-RVDLSALDFYLALQDTLAQ-RGIPCPQPLAD
GGGR-----YWRMLCDKPAALLTCLS--GAALETPGAAHCHAVGAMLAHLHLAAANMP--------------
-----------------------------------------N-----PLPN-PCGAN-W---RQTVGAALL-
-----------PLVSAEEHDLLADELAYQALQ---------------------------------------D
WS-KLP------RGVIHADLFRDNVLWD-----------------------------STGR----LTGVLDF
YFAGEDAWLFDLAVVANDWC--------FDETTLATLLAGYTTQRPLIEAERAAWPAMRRAAALRFWLLRLE
-VRHQPRAGEV-VTIKN-PDDFRHLLARFRL-A---PEALPR------------------------------
---
>gi|72605596|EAO41582
------------------------MAVYTEVSTQEARALLRQL-KLGELTAMQGCTKG---IENTNYFVSTE
------------------------------QGDYVLTLFE-RLTLAQLPFYLRLMKHLAE-RGIPVPEPSAN
ARGD-----LVFEFKAKPAAVVTRLR--GSSELSPTPAHCAAIGTTLAKMHLAARDFP--------------
-----------------------------------------L-----SQPN-LRGLA-W---WNETVPVVL-
-----------PHVNPTQAALLQSELAYQNHVAA-----------------------------------SSA
YA-ALP------RGPIHADLFRDNVMFD------------------------------NGQGQLELTGVFDF
YFAGVDSWLFDLAVCLNDWCIDL--DTTHDGERFQSFLRAYSAVRPLESAERALLPALLRAAALRFWISRLW
-DYYLPRPASL-LQPHD-PAHFERVLQQRVM-H---PQAANSLEMQP-------------------------
---
>gi|73540573|YP_295093
------------------------MAVFTTVSHDEIASWLLDY-DLGEVRELRGIASG---IENSNFFLTTE
------------------------------QDEYVLTIFE-RLTFDQLPYYLHLMAHLAT-RGITVPAPIPA
RDGE-----ILRALKGKPATIVTRLP--GASQLAPDAEHCAEVGDMLARMHLAGQDYP--------------
-----------------------------------------R-----QQPN-LRSLP-W---WQQTEAEIV-
-----------PFLDAQQRTLLQQEIAHQAAFFG-----------------------------------SAD
YA-ALP------GGPCHCDLFRDNALFE----------------------------EVGGH--HRLGGFFDF
YFAGNDKWLFDLAVTVNDWCIDL--ASELDNARAHAMVQAYHAVRPLSATEAAHWRDMLRAGALRFWVSRLW
-DFYLPREADM-LQPHD-PTHFERILRRRLA-M---TADAAALAWI--------------------------
---
>gi|7379161|CAB83710
------------------------MSVYTSVSDDEMRGFLSGY-DLGEFVSLQGIAQG---ITNSNYFLTTT
------------------------------SGRYVLTVFE-VLKQEELPFFLELNRHLSM-KGVAVAAPVAR
KDGR-----LDSVLAGKPACLVACLK--GSDTALPTAEQCFHTGAMLAKMHLAAADFP--------------
-----------------------------------------L-----EMEN-PRYDA-W---WTEACARLL-
-----------PVLSQDDAALLRAEIDALKDN---------------------------------------L
GN-HLP------SGIIHADLFKDNVLLD------------------------------GGQ----VSGFIDF
YYACRGNFMYDLAIAVNDWARTA--DNKLDEALKKAFIGGYEGVRPLSAEEKAYFPTAQRAGCIRFWVSRLL
-DFHFPQAGEM-TFIKD-PNAFRNLLLSLG------------------------------------------
---