Kinase Family Mean % Identity between ePK domain orthologs Lowest % Identity between ePK domain orthologs Highest % Identity between ePK domain orthologs CASK 100.0 100.0 100.0 CAMK2 99.9 99.6 100.0 TLK 99.8 99.6 100.0 CK2 99.7 99.3 100.0 Tie 99.6 99.6 99.6 PDK1 99.6 99.6 99.6 AKT 99.6 99.2 100.0 PSK 99.6 99.6 99.6 PKD 99.6 99.2 100.0 Abl 99.6 99.6 99.6 CK1 99.5 98.5 100.0 PKG 99.4 98.8 100.0 Wnk 99.4 98.5 100.0 TTBK 99.2 98.4 100.0 CAMK1 99.1 98.0 100.0 GSK 99.1 98.2 100.0 NKF4 99.1 98.8 99.4 MLK 98.8 95.3 100.0 PKC 98.7 92.5 100.0 FGFR 98.6 97.1 100.0 FAK 98.5 97.7 99.2 RAF 98.4 95.8 100.0 STE7 98.3 94.3 100.0 EGFR 98.3 96.1 99.6 Ryk 98.1 98.1 98.1 STE20 98.0 91.0 100.0 DYRK 98.0 90.2 100.0 CDK 97.9 94.0 100.0 STKR 97.9 85.9 100.0 CLK 97.9 94.3 100.0 RSK 97.8 92.9 100.0 Trk 97.7 95.6 99.3 NDR 97.7 96.1 98.7 STE11 97.6 94.7 99.6 VPS15 97.5 97.5 97.5 PLK 97.5 95.7 99.6 SGK 97.4 94.6 99.2 Syk 97.4 95.6 99.2 Ror 97.4 96.1 98.7 MAPKAPK 97.4 96.2 98.6 Eph 97.4 90.2 100.0 CAMKL 97.3 88.9 100.0 Musk 97.2 97.2 97.2 RCK 97.0 96.1 97.9 DMPK 96.9 92.0 100.0 LISK 96.7 95.7 97.4 NRBP 96.7 94.2 99.2 Axl 96.6 93.6 98.9 DAPK 96.6 94.6 98.9 Csk 96.5 93.9 99.2 MAPK 96.5 76.5 100.0 MAST 96.4 87.3 99.6 RSKb 96.4 89.1 100.0 Ack 96.2 93.5 98.8 MLCK 96.2 94.5 98.8 PKN 96.2 90.8 99.2 CAMKK 96.0 93.4 98.6 IKK 95.8 91.5 98.0 InsR 95.8 93.7 97.4 NAK 95.7 93.0 98.5 Slob 95.6 95.6 95.6 CCK4 95.5 95.5 95.5 ULK 95.5 85.4 98.9 Ret 95.4 95.4 95.4 DCAMKL 95.1 89.5 98.4 PIM 95.0 92.2 97.6 YANK 95.0 93.1 97.7 PKA 94.9 86.7 99.2 CDKL 94.8 91.9 100.0 PHK 94.8 93.3 96.3 Tec 94.8 87.7 98.8 Trio 94.7 88.1 99.6 Fer 94.5 92.9 96.1 CAMK-Unique 94.5 83.5 100.0 PDGFR 94.9 93.1 94.9 VEGFR 93.2 91.5 96.3 GRK 94.3 85.6 99.6 LRRK 94.2 94.1 94.4 Src 94.2 81.5 99.6 TSSK 94.1 89.6 97.3 DDR 94.0 92.9 95.1 SRPK 94.0 90.6 97.6 NEK 93.7 80.5 99.6 Lmr 93.7 92.0 95.9 SCY1 93.6 90.0 97.3 Met 93.5 89.3 97.7 Alk 93.5 88.9 98.1 TBCK 93.4 93.4 93.4 RGC 93.3 86.5 99.3 AUR 93.0 91.2 94.8 Sev 93.0 93.0 93.0 Trbl 92.9 81.9 99.2 JakA 92.4 82.7 97.8 IRE 92.2 89.7 94.7 RAD53 92.1 92.1 92.1 STE-Unique 91.5 89.2 95.7 WEE 90.7 81.8 95.6 JakB 89.8 83.1 95.5 TOPK 89.5 89.5 89.5 TTK 88.4 88.4 88.4 Bud32 87.7 87.7 87.7 VRK 86.6 81.3 93.6 NKF3 85.6 83.0 88.2 Other-Unique 85.4 65.6 99.3 RIPK 84.2 71.5 94.7 Haspin 83.4 83.4 83.4 IRAK 82.6 72.0 87.7 PEK 82.1 67.8 89.7 CDC7 82.0 82.0 82.0 BUB 82.0 81.5 82.5 NKF2 81.3 81.3 81.3 TK-Unique 80.9 80.9 80.9 RSKL 79.3 74.4 84.3 NKF1 79.2 52.7 98.5 NKF5 78.3 78.3 78.3 MOS 75.1 75.1 75.1 TKL-Unique 68.7 68.7 68.7