CLUSTAL W (1.83) multiple sequence alignment Bub1_Dmel FEVSKMIGKGAYGSVYVGKH---------------------------LKSGKKVALKQER CG14030_Dmel FSIDKEVGRGSYGSVYKATD---------------------------SRTGNVVALKYQK BUBR1_Mmus LEIGKEIELGPEDYVIKQEHLTCDD--------------YRLFWVAPRSSAELTMIKASS BUB1_Mmus VYVNHLLGEGAFAQVFEAIHGDV-----------------R-----NAKSEQKCILKVQR R06C7.8_Cele LHIQTLIGQGGYAKVYRAVT----------------------------DDQRTVAVKYEV BUB1_Scer YCIRGELGEGGYATVYLAE----------------------------SSQGHLRALKVEK BUB1_Hsap VYVHHLLGEGAFAQVYEATQGDL-----------------N-----DAKNKQKFVLKVQK BUBR1_Hsap LEIEKEIELGNEDYCIKREYLICED--------------YKLFWVAPRNSAELTVIKVSS Bub1_Ddis -----------------------------------------------TSEDSWLSCKVQD BUB1_Spur YSVMEKVGEGAFATIYLAACLDALD--------------MT----DLDRDFRRVALKVQH CC1G_07078_Ccin FMLSEKLGEGGFGSVYKARDLGMRTGDDDDDDDDDDFDDFD----DDEENASMVAIKVVK AqueK151_Aque CSVIGKLAKGGFASVYNVK----------------------------MMNGSTKALKIQN BUB_a-2_Smoe ------------------------------------------------------------ BUB_a-1_Smoe ------------------------------------------------------------ Bub1_Dmel PTNYWEFYICLEIHSRLTSE----QMIPSYAHIDYALVGNNSSVYISE-FSDYGSLIGVC CG14030_Dmel PPNTWEIYICDQVLKRIKEP----EVLPGVMDISTAIIAPNASLIATE-FSPFGSLLDIN BUBR1_Mmus QPIPWDFYINLKLKERLNEDYDQ---------LCSCCQYQDGHVVWYQ-YINCSTLQNLL BUB1_Mmus PANSWEFYIGMQLMERLKPE-----VHHMFIKFYSAHLFKNGSILVGE-LYSYGTLLNVI R06C7.8_Cele PSCSWEVYICDQMRNRLKDRGLELMAKCCIMEVMDAYVYSTASLLVNQ-YHEYGTLLEYA BUB1_Scer PASVWEYYIMSQVEFRLRKS----TILKSIINASALHLFLDESYLVLN-YASQGTVLDLI BUB1_Hsap PANPWEFYIGTQLMERLKPS-----MQHMFMKFYSAHLFQNGSVLVGE-LYSYGTLLNAI BUBR1_Hsap QPVPWDFYINLKLKERLNEDFDH---------FCSCYQYQDGCIVWHQ-YINCFTLQDLL Bub1_Ddis PPSIWEFYIGNQIHQRLQERSLTI-SNSKFPTIHSLYYYTDKSIMLMDHTIDQGTLDDVV BUB1_Spur PPCPWEMYVIKELHARLSRLPSQIDVRPSIMTAECAHIYQDKSCMVTE-YKSKGTLLDLI CC1G_07078_Ccin PRNLWEYHALRRLHSALPAN-----LRRSLVLPHGLYAYGDESFLILD-LCTQGMLLDIV AqueK151_Aque PPCLWEVAIIEELHKRLKANDLLK-FSQCFMSVDAVHLYTNSSIIAYN-YYPHGTLLDLV BUB_a-2_Smoe -------------------------------------------------YGQHGTLQDVV BUB_a-1_Smoe -------------------------------------------------YGQHGTLQDVV : Bub1_Dmel NKVKSVT----NRNMDEYVVMHLSCQMLDIVDHLHAMGIIHADIKPDNFLLMKPIC---- CG14030_Dmel NKIRQAT----TKVMHESLVMHFSAQICNIVDHLHRQHIIHADIKPDNFLLMRVPN---- BUBR1_Mmus QHS---------EFVTHEIIVLIIYNLLTIVEKLHRAEIVHGDLSPRSLILRNRIHDPYD BUB1_Mmus NLYKNTS----EKVMPQALVLTFAIRMLYMVEQVHSCEIIHGDIKPDNFILGHRFLEQAD R06C7.8_Cele NNMKDPN---------WHITCFLITQMARVVKEVHASKIIHGDIKPDNFMITRKIDDKWG BUB1_Scer NLQREKAID-GNGIMDEYLCMFITVELMKVLEKIHEVGIIHGDLKPDNCMIRLEKPG-EP BUB1_Hsap NLYKNTP----EKVMPQGLVISFAMRMLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDD BUBR1_Hsap QHS---------EYITHEITVLIIYNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPYD Bub1_Ddis SST--NG-----VPMEEPLAMFHCIELLKMIEDLHLVGIIHGNICANNLHFLFGQT-S-D BUB1_Spur NKVKAVN----KKDLSEDWVLFFAIEILQTVEYMHRCKIIHGDIKPDNFLINTDNDENFT CC1G_07078_Ccin NNAASAGISQAGACLDELLVIFFTIELLRLVEGMHSAGFIHGDLKIDNCLLRLEDVPGGA AqueK151_Aque NTCRTTS-----KKLTEAVLLYYTTEICQLVEALHCCGIIHADIKPDNIMLRDIRP-I-- BUB_a-2_Smoe NAYLAHS-----LKMDELLCMYYTIEMLRMLEVLHGVGIIHADFKPDNLLIRNES----- BUB_a-1_Smoe NAYLAHS-----LKMDELLCMYYTIEMLRMLEVLHGVGIIHADFKPDNLLIRNDRYLLVS . .: :. :* ::*.:: : Bub1_Dmel ------------ADPNEVSLQLIDFGVSIDMKLFPDN--QTFNYVHHDDLF----K---- CG14030_Dmel ------------VDSPLPSLRLIDFGCAIDMTLFPDGEKTKFRKVVQTDGF----T---- BUBR1_Mmus -----------YVNKDDHAVRIMDFSYSVDLRVQLDA--FAYSGFRTAQIL----E---- BUB1_Mmus ------------E-DLATGLALIDLGQSIDMKLFPKG--TVFTGKCETSGF----Q---- R06C7.8_Cele KD--------ALMSNDSFVIKIIDWGRAIDMMPL-KN--QRFKGRAGTEAF----D---- BUB1_Scer --LGAHYMRNGEDGWENKGIYLIDFGRSFDMTLLPPG--TKFKSNWKADQQ----D---- BUB1_Hsap ------------EDDLSAGLALIDLGQSIDMKLFPKG--TIFTAKCETSGF----Q---- BUBR1_Hsap ------------CNKNNQALKIVDFSYSVDLRVQLDV--FTLSGFRTVQIL----E---- Bub1_Ddis WPDW--TAGECKGAWKSKGFTLTDFSRSIDTTIYSQD--ARYQSPIELLPIGTPLEWLKI BUB1_Spur -----------CSQEPSSLVKLIDFGRSIDMTLFPEG--TVFTAKCKTSGF----N---- CC1G_07078_Ccin AAWSSLYQPSGEGGWQYKGLKVIDFGRTIDTRLFPAD--QQFIAEWPTDER----D---- AqueK151_Aque -TDY--------TSIRGRGVCLLDFGRAIDAQSFPRG--TQFVGSCGTDSF----Q---- BUB_a-2_Smoe --RG--------LCLALQGLCLIDWGRSIDMRLFPEG--TEFLADSKTSAF----R---- BUB_a-1_Smoe VPRG--------LCLALQGLCLIDWGRSIDMRLFPEG--TEFFADSKTSAF----R---- . : * . :.* Bub1_Dmel CIEMRTGRPWTYQLDLYGLVSVMH-VLLFGRY-MEV------VQRSPSTIWMP-KTNVP- CG14030_Dmel CIEMQEGRSWSYETDLFCIAATVH-VMLFGDY-MQP------QKK--GSSWEI-RQKLP- BUBR1_Mmus GQKILANCSSPYHVDLLGIADLAH-LLLFKEH-LHV------FWD--GLLWKL-SQSTS- BUB1_Mmus CPEMLSNKPWNYQIDYFGVAATIY-CMLFGSY-MKV------KNE--GGVWKP-EGLFR- R06C7.8_Cele CPEMVDGRSWTYQADYFGFAATMA-VVVAGKY-AQL------TGASV-GDYSL-NVDIKR BUB1_Scer CWEMRAGKPWSYEADYYGLAGVIH-SMLFGKF-IET-----IQLQNG--RCKL-KNPFK- BUB1_Hsap CVEMLSNKPWNYQIDYFGVAATVY-CMLFGTY-MKV------KNE--GGECKP-EGLFR- BUBR1_Hsap GQKILANCSSPYQVDLFGIADLAH-LLLFKEH-LQV------FWD--GSFWKL-SQNIS- Bub1_Ddis NQSSTTNVGWSYNLDYLGICKVMFHILTCGKEELKL------SLSQQTGKLEIINQSII- BUB1_Spur CTEMQSDQPWTYQVDYYGIAGTVH-CLMFGKY-MKV------FRE--GGIWKM-TSKVP- CC1G_07078_Ccin CFEIREGRPWTYQTDYFGLAGIIY-CMLFGKY-ITSSAVVQVQGQHGETRYKI-GTPLK- AqueK151_Aque CIQMLNNEPWSWHTDLHCIAGTVH-VLLHLDY-MEV------IKNAMTGEYVP-SKSLP- BUB_a-2_Smoe CIEMMEERPWTYQVDGYGLCCIVH-CMLH------------------------------- BUB_a-1_Smoe CIEMVEERPWTYQVDGYGLCCIVH-CMLH------------------------------- . :. * . : Bub1_Dmel R---YFQ-RTMWENIFRTLLNIRDCR--TMPNLQQL------------------------ CG14030_Dmel R---YLK-KHVWTKFFGDLLNMQA-D--KLPALHEMRLIF---E---------------- BUBR1_Mmus E---LKD-SELWNKFFVRILNASDKS--TVSVLGEL------------------------ BUB1_Mmus R---LPH-LDMWEEFFHIMLNIPDCH--NLPSLDFL------------------------ R06C7.8_Cele R---NIL-RDACYDVINRFLNIPSCD--SLPDWNILIKSF-------------------- BUB1_Scer R---YWK-KEIWGVIFDLLLNSGQASNQALPMTEKIVEIRNLIESHLEQHAENHLRNVIL BUB1_Hsap R---LPH-LDMWNEFFHVMLNIPDCH--HLPSLDLL------------------------ BUBR1_Hsap E---LKD-GELWNKFFVRILNANDEA--TVSVLGEL------------------------ Bub1_Ddis QKDSFSELDTLWLPFLTTLLNHNGENGN--QQTTTTTYIL---K---------------- BUB1_Spur R---CAK-V-DWKGFFHTLLNVPSCDPSDLPHLGDL------------------------ CC1G_07078_Ccin R---YWQ-ADLWNRLFDILL---------------------------------------- AqueK151_Aque R---NYD-RVLWMKFFTDLLNWSGEGQ---PDMKALTQPL---S---------------- BUB_a-2_Smoe ------------------------------------------------------------ BUB_a-1_Smoe ------------------------------------------------------------ Bub1_Dmel ---------------RTQL CG14030_Dmel ----E-EAYRMDSELQKQI BUBR1_Mmus -----------------AA BUB1_Mmus ---------------RQNM R06C7.8_Cele -------S-EI--WNEKFE BUB1_Scer SIEEELSHFQYKGKPSRRF BUB1_Hsap ---------------RQKL BUBR1_Hsap -----------------AA Bub1_Ddis ----Q-QR-NLFENYLQSN BUB1_Spur ---------------RRQL CC1G_07078_Ccin ------------------N AqueK151_Aque ----R-KL-SL--NVSHLK BUB_a-2_Smoe ------------------G BUB_a-1_Smoe ------------------G