CLUSTAL W (1.83) multiple sequence alignment VACAMKL_Hsap YDLG-QVIKTEEFCEIFRA--KDKTT---------------------------------- PRR1_Scer WKKV-RPIGSGNFSTVLLYELMDQSNPKLKQ----------------------------- MEK1_Scer WEITNRIVGNGTFGHVLIT--HNSKERDE------------------------------- VACAMKL_Mmus YDLG-QVIKTEEFCEIFRA--KDKTT---------------------------------- YKL171W_Scer HRLG-KIIGFGAWGIIREC--FDIET---------------------------------- YMR291W_Scer VTNH-NSLGDGNFSVVKEC--MNIHT---------------------------------- 5683_Tthe YKMI-KLIGKGSFGKVRLA--TNVNGK--------------------------------- CC1G_13697_Ccin -----QCLGTGSFATVHLA--FDPTH---------------------------------- CC1G_07362_Ccin FEVV-RVLGTGSYAVVYLV--REILSRPP------------------------------- CC1G_09141_Ccin LRLL-RPLGQGAFSAVWLA--EDLSSIPLVLSSKRSVRDLKRQASLQSKGSVSRKSSLKS CC1G_07180_Ccin YTLG-KVVGFGAFSTIRTG--VSE-S---------------------------------- AqueK053_Aque YSLG-EMLGKGAFGVVWEA--TSVNS---------------------------------- GK018_Glam YILM-KKLGSGGFSTVYKA--MDLST---------------------------------- . : : : . VACAMKL_Hsap ------------------------------------------------------------ PRR1_Scer ------------------------------------------------------------ MEK1_Scer ------------------------------D----------------------------- VACAMKL_Mmus ------------------------------------------------------------ YKL171W_Scer ------------------------------------------------------------ YMR291W_Scer ------------------------------------------------------------ 5683_Tthe ------------------------------------------------------------ CC1G_13697_Ccin ------------------------------------------------------------ CC1G_07362_Ccin -PSEDG--HMTTIG--------------SMDMDGT------------------------- CC1G_09141_Ccin PTSSRGVSRNSSMKRFMARVTGTQPSVDSLLLDGHVHHEGRETTWTSPDGHLHPMPPSSM CC1G_07180_Ccin ------------------------------------------------------------ AqueK053_Aque ------------------------------------------------------------ GK018_Glam ------------------------------------------------------------ VACAMKL_Hsap -----------------------------------------GKLHTCKKFQKRDG----- PRR1_Scer --------------------------------------------VAVKRLKYPEELSNVE MEK1_Scer -------------------------------------VCYHPENYAVKIIKLKP------ VACAMKL_Mmus -----------------------------------------GKLHTCKKFQKRDG----- YKL171W_Scer -----------------------------------------GVGRVIKIVKFKG------ YMR291W_Scer -----------------------------------------KDLYAMKLIKKQTV----- 5683_Tthe -------------------------------------------EFAVKSILKADA----- CC1G_13697_Ccin -----------------------------------------HKQVACKSIRTRREN---- CC1G_07362_Ccin ------------------------------------PQLEYGREYAIKLLSKANL----- CC1G_09141_Ccin HPSPSPSSSISSLPSPEVGLGASLSRQSSTSTRRSATSRAEARVVAVKLTPRRPEPNS-- CC1G_07180_Ccin -----------------------------------------GSTVAVKIVRRADLV---- AqueK053_Aque -----------------------------------------KEKFAIKMVHKDKP----- GK018_Glam -----------------------------------------AQIVALKISRKETSLE--- . * VACAMKL_Hsap -------------RK-VRKAAKNEIGILKMV-------------------KHPNILQLVD PRR1_Scer QINTSLRYKE--TLSRLENSLTRELQVLKSL-------------------NHPCIVKLLG MEK1_Scer ------------------NKFDKEARILLRL-------------------DHPNIIKVYH VACAMKL_Mmus -------------RK-VRKAAKNEIGILKMV-------------------KHPNILQLVD YKL171W_Scer -------------HQNIKKHVLREVAIWRTL-------------------KHNRILPLLD YMR291W_Scer -------------KN-KIQLIQREFDLLRSISEKIRDMEKKNEHSLDIFEGHHHILQLFD 5683_Tthe -------------GE-RYYLLRRELDIMKKV-------------------DHPNLVKFYE CC1G_13697_Ccin ---------------EVRQ-VLKEVRILMTL-------------------KHPNINEIYD CC1G_07362_Ccin -------------DEEALAAQMTEVTIHQSL------------------PLHPNIVTLHR CC1G_09141_Ccin --------PL--TEERTRVGFIREVEVLRHI-------------------SHPNITPLLA CC1G_07180_Ccin -------RTG--HAPEERKRLQHEASIWSSL-------------------SHEHILPLFS AqueK053_Aque -------------GSVSIQLLEREIQVLNHV-------------------DHPHIIKLVE GK018_Glam -------GDEHIAETKRWLFLNREAAIYHHL-------------------KHPNIVQLNS * : : * : . VACAMKL_Hsap V----------------FVTR-KEY---------------FIFLELATGREVFDWILDQG PRR1_Scer I--NN----------PIFVTS-KKPLCDLIIKTPRALPPCDMIMSYCPAGDLLAAVMARN MEK1_Scer T----------------FCDRNNHL---------------YIFQDLIPGGDLFSYLAKGD VACAMKL_Mmus V----------------FVTR-KEY---------------FIFLELATGREVFDWILDQG YKL171W_Scer W----------------KLDDNYAM---------------YCLTERINDGTLYDLVISWD YMR291W_Scer Y----------------FETA-DNI---------------VLITQLCQKGDLYEKIVENQ 5683_Tthe T----------------YHDD-KYL---------------HIVMEFVQGKELSQYCQERF CC1G_13697_Ccin ----------------TEEDN-GFI---------------HIFLQLCTGGDLFTYISTVN CC1G_07362_Ccin T----------------LETP-SFL---------------LLLLEYVPGEDLFYFLEQAR CC1G_09141_Ccin H----------------FSTP-TYH---------------VLVLPYLKGGDLLSLVNNDA CC1G_07180_Ccin A----------------LHT-SYAD---------------YFVTIYCPAGSLYDILKRDG AqueK053_Aque V----------------FETP-KKV---------------FMVLELCRGGELSDILKEKK GK018_Glam DPIFVNSTTGRIVLNPAYEPY-NEI---------------ALSMELCEGGDLHDFLALLC : VACAMKL_Hsap YYS----------------------------------E--RDTSNVVRQVLEAVAYLHSL PRR1_Scer ---G------------------------------RLEA--WLIQRIFTEVVLAVKYLHEN MEK1_Scer CL-T------------------------------SMSE--TESLLIVFQILQALNYLHDQ VACAMKL_Mmus YYS----------------------------------E--RDTSNVVRQVLEAVAYLHSL YKL171W_Scer EFKRSK-I--------------------------PFAERCRLTIFLSLQLLSALKYMHSK YMR291W_Scer CLDL---------------------------------E--TQVTSYCACLVSVLEFLHSQ 5683_Tthe EVNR------------------------------KFTE--SEVAFIVRKLLSALSHMHNL CC1G_13697_Ccin LKAD-R-P--------------------------GLCE--AES----------------- CC1G_07362_Ccin DHYEPQPSDFVMYNSRTPPTPSLLSNLHPSQLLSRTRL--RLIASMFSQMCDAVAACHST CC1G_09141_Ccin VW-G------------------------------RLSE--SVLRRIWCEICRAVGWMHSV CC1G_07180_Ccin RPA--------------------------------LPQ--DDAGMMFRQVVRGLRYLHEV AqueK053_Aque SFKEN-V----------------------------------------------------- GK018_Glam RS-D-K-Q--------------------------ARTE--HELLTILLQIAEALKYLHTL VACAMKL_Hsap --KIVHRNLKLENLVYYNRLK--------------------------------NSKIVIS PRR1_Scer --SIIHRDLKLENILLKYSFDDI-NSFRDS------------------PIYCKQNFIELA MEK1_Scer --DIVHRDLKLDNILLCTPEP--------------------------------CTRIVLA VACAMKL_Mmus --KIVHRNLKLENLVYYNRLK--------------------------------NSKIVIS YKL171W_Scer --TIVHGDIKLENCLLQKEGKK------------------------------SDWKVFLC YMR291W_Scer --GIVHRDLKAENVLFRLRVNENEKNLQGEHHG-------------DFKYDLLAHDLVLA 5683_Tthe --GIIHRDIKLENIMINES----------------------------------NLDVKIL CC1G_13697_Ccin ------------------------------------------------------------ CC1G_07362_Ccin --QVFHRDIKPENFIVTDGWVML-ANG----------------------RQERKVIVKLT CC1G_09141_Ccin --GIVHRDIKLENVLLTWDGLQSYSNLISTELSSTPTESSILSIPRPTVADLPTPIVKLT CC1G_07180_Ccin -AGLVHRDIKLENVLVDESG-----------------------------------VCRIG AqueK053_Aque ------------------------------------------------------------ GK018_Glam DSPITHNDISLRNILLAEGG-----------------------------------VWKLS VACAMKL_Hsap DFHLAKLEN--------------------------------------------------- PRR1_Scer DFGLCKKIEN-------------------------------------------------- MEK1_Scer DFGIAKDLNSN------------------------------------------------- VACAMKL_Mmus DFHLAKLEN--------------------------------------------------- YKL171W_Scer DFGMSCHFDEKHE----------------------------------------------- YMR291W_Scer DFGLAAEYNTS------------------------------------------------- 5683_Tthe DFGLSRDFSQS------------------------------------------------- CC1G_13697_Ccin ------------------------------------------------------------ CC1G_07362_Ccin DFGLSTTDI--------------------------------------------------- CC1G_09141_Ccin DFGLSRFIDIGNGE---------------------------------------------- CC1G_07180_Ccin DFGLSVRIGDVDDEDGMDHHHHEHHPIDGACTGNIHRAVSLSFPSKRHRAATTLGAAIAR AqueK053_Aque ------------------------------------------------------------ GK018_Glam DFTLVKPLADKK------------------------------------------------ VACAMKL_Hsap ------------GLIKEPCGTPEYLAPEVVGR-----------------QRYGRPVDCWA PRR1_Scer -----------NEMCTARCGSEDYVSPEILMG----------------VPYDGHLSDTWA MEK1_Scer ----------K-ERMHTVVGTPEYCAPEVGFRANRKAYQSFSRAATLEQRGYDSKCDLWS VACAMKL_Mmus ------------GLIKEPCGTPEYLAPEVVGR-----------------QRYGRPVDCWA YKL171W_Scer ------------PEPSKYIGSLPYASPELLDFPC-------------IVSPLGPASDIWA YMR291W_Scer ----------KVNSLKEFVGTISYIAPEIVKCKGV-GEMTPDQV--GKLDKYGCPVDIWA 5683_Tthe ----------QASILQSIVGTPLYVAPEVIN-----------------EQPYDQKSDSWS CC1G_13697_Ccin ------------------NGSHPFDND-------------------------ATYQSSWA CC1G_07362_Ccin ------------DSSDVDCGSAPYMSYECRNNIA--------------PTYRPRDADVWS CC1G_09141_Ccin --------RGQGEMLNTRCGSEAYAAPELVMGGGP------------RGVYDGRETDAWA CC1G_07180_Ccin HNSTRNRHAGQ-SSHVYQPGSLPYAAPELLLPNTA------------DMAPAHPGQDIWA AqueK053_Aque ------------------------------------------------------------ GK018_Glam ----------EVQMVTSLAGTKPFTAPEKLLQ-----------------GVFGPASDMYS VACAMKL_Hsap IGVIMYILLS-------GNPPFYEEVEE----------------------DDY--ENHDK PRR1_Scer LGVILYSLFE-------DRLPFDPPPNA----------------------SARQ---RSR MEK1_Scer LGVITHIMLT-------GISPFYGDGSE-------------------------------R VACAMKL_Mmus IGVIMYILLS-------GNPPFYEEVEE----------------------DDY--ENHDK YKL171W_Scer LGVMLYTMLV-------GKLPFNHEFEP----------------------R--------- YMR291W_Scer LGVLTYFMAF-------GYTPFDCTTDD----------------------E--------- 5683_Tthe MGVLMYYLIS-------GSHPFEASNI--------------------------------K CC1G_13697_Ccin DDADSYTSVPTESQQCLGSFSEHRQA---------------------------------- CC1G_07362_Ccin LGIVLINMLY-------HFNPW-------------------------------------- CC1G_09141_Ccin CGVVLYALVG-------RKLPFGEGVGIGMDGGHGTQSHINGERVHPPGYSSRKHAVERR CC1G_07180_Ccin LGVMLYALLT-------GHLPFNDSFEP----------------------R--------- AqueK053_Aque ---------------------T-------------------------------------- GK018_Glam YGVVAFACFV-------GNINLFLAP---------------------------------- VACAMKL_Hsap NLFRKILAGDYEF----------------------------------------------- PRR1_Scer ATSHRIARFDWRW----------------------------------------------- MEK1_Scer SIIQNAKIGKLNF----------------------------------------------- VACAMKL_Mmus NLFRKILAGDYEF----------------------------------------------- YKL171W_Scer -LRSLIKVGEFDRF---------------------------------------------- YMR291W_Scer -TLECISKCDYYV----------------------------------------------- 5683_Tthe ELFKNICSANFNF----------------------------------------------- CC1G_13697_Ccin RLKARIVEEEVVF----------------------------------------------- CC1G_07362_Ccin ------------------------------------------------------------ CC1G_09141_Ccin AWLMRIAKGEYEW----------------------------------------------- CC1G_07180_Ccin -LQMKILNGTFEIPADIGRGAERILQGCMERIITKRWTIAMVDEVSWGVGWGSAGDNATP AqueK053_Aque ------------------------------------------------------------ GK018_Glam NNFAEIP----------------------------------------------------- VACAMKL_Hsap ------------------------------------------------------------ PRR1_Scer ------------------------------------------------------------ MEK1_Scer ------------------------------------------------------------ VACAMKL_Mmus ------------------------------------------------------------ YKL171W_Scer ---------------------------------------------------SLAQ----- YMR291W_Scer ------------------------------------------------------------ 5683_Tthe ------------------------------------------------------------ CC1G_13697_Ccin ------------------------------------------------------------ CC1G_07362_Ccin ------------------------------------------------------------ CC1G_09141_Ccin ------------------------------------------------------------ CC1G_07180_Ccin DESQEDLLAFHAITSPLSAKSCSESRLDRLTIPESDEDDWQHEEHHFTRSAIEAGSRRSS AqueK053_Aque ------------------------------------------------------------ GK018_Glam ------------------------------------------------------------ VACAMKL_Hsap -----------------------------D------------------------------ PRR1_Scer -----------------------------Y------------------------------ MEK1_Scer -----------------------------K------------------------------ VACAMKL_Mmus -----------------------------D------------------------------ YKL171W_Scer -------------------------VCKFD------------------------------ YMR291W_Scer -----------------------------D------------------------------ 5683_Tthe -----------------------------R------------------------------ CC1G_13697_Ccin -----------------------------L------------------------------ CC1G_07362_Ccin ------------------------------------------------------------ CC1G_09141_Ccin -----------------------------P------------------------------ CC1G_07180_Ccin SRAKRSQSRAPMSARSHSRQCSPHRSARSSSRMYSGFSSAAVSRSHSPATSPLFENPPSR AqueK053_Aque ------------------------------------------------------------ GK018_Glam ------------------------------------------------------------ VACAMKL_Hsap -----------------------SPY----------------WD-DISQAAK-DLV---- PRR1_Scer -----------------------RL-SD-----------------YKTNVGK-QIV---- MEK1_Scer -----------------------LKQ----------------WD-IVSDNAK-SFV---- VACAMKL_Mmus -----------------------SPY----------------WD-DISQAAK-DLV---- YKL171W_Scer -----------------------RKKN---------------EG-TIGQGLY-DTV---- YMR291W_Scer -----------------------EQMM---------------HD-PKYEQFW-NFV---- 5683_Tthe -----------------------SSA----------------WS-GISKSAK-VLI---- CC1G_13697_Ccin -----------------------HCP----------------WS-NLPQ-AK-ALV---- CC1G_07362_Ccin ------------------------------------------------------------ CC1G_09141_Ccin -----------------------EVPSDAAAVEDGDGELVGPRL-ALSEGAK-RVV---- CC1G_07180_Ccin SRSQSRHRGRQPNKRCYFASRSPSPSW----------------V-PSTPSDI-SHISRLS AqueK053_Aque ------------------------------------------------------------ GK018_Glam -------------------------G----------------RGSLMDR-ARADLC---- VACAMKL_Hsap ----TRLMEVEQDQRITAEEAISHEWI PRR1_Scer ----ENTLT-RKNQRWSINEIYESPFV MEK1_Scer ----KDLLQTDVVKRLNSKQGLKHIWI VACAMKL_Mmus ----TRLMEVEQDQRITAEEAISHEWI YKL171W_Scer ----IGCLTIDLDKRWKLKRI--EEVL YMR291W_Scer ----QCCFTIDPAVRRSAKNLKQHPFI 5683_Tthe ----TQFLNLDPKSRISCEEALQSDWF CC1G_13697_Ccin ----QNLLVHDYRRRANVFEALDSEWM CC1G_07362_Ccin -------------------------TD CC1G_09141_Ccin ----GRLLVRDPKKRARIVDLWEDDWM CC1G_07180_Ccin LREPSEDLHLDSPPRGRTRFSLHHETF AqueK053_Aque -------------------------DF GK018_Glam ----S----------GTCYVCNPSDRV