CLUSTAL W (1.83) multiple sequence alignment CG5790_Dmel FDVHCRIGSGTFSTVLLGTLQRERG----------------------LVETQRRRFAIKH CG8655_Dmel FDVHSRIGNGTFSTVLLGTLRRESH----------------------LPDSLRRKFAIKH CDC7_Mmus FKIKDKIGEGTFSSVYLATAQLQ--------------------------EGHEEKIALKH C34G6.5_Cele ------------------------------------------------------------ CDC7_Scer YKLIDKIGEGTFSSVYKAKDITGKITK--------------KFAS-HFWNYGSNYVALKK CDC7_Hsap FKIEDKIGEGTFSSVYLATAQLQ--------------------------VGPEEKIALKH Cdc7_Ddis YRILEKIGQGTFSGVYKSVCIDGP--------------------------NIGLIVALKR 7318_Tthe YLVNKELGRGGYGVVYKAYEYRDGV------------------------VNKKKKFAIKI Cdc7_Spur FTVLDKIGEGTFSSVYRATLKKT--------------------------PDCNQEFALKH CC1G_08833_Ccin YKLLDRLGTGTFSSVYKALDLRYHEYDNSPWLGHHPEESSAHFQSVPRPEGSRVFVAIKR AqueK154_Aque FNVLSKLGEGTFSSVYLASVKTD----------------------------SSVMVALKH CDC7_b_Smoe YRIEGVEGSGAYSVVFKARRFGDG-----------------------------RLFAIKC CDC7_a_Smoe YRIEGVEGSGAYSVVFKARRFGDG-----------------------------RLFAIKC GK046_Glam YKITQHVGKGAFSKVFLAYTPE------------------------------FQRRAIKR CG5790_Dmel HNP--------------------TNHPERILRELECMYR------------------IGG CG8655_Dmel HIP--------------------TSHPDRIMKELQCMTK------------------MGG CDC7_Mmus LIP--------------------TSHPMRIAAELQCLTV------------------AGG C34G6.5_Cele ---------------------------SMLSIELELLSE------------------LGG CDC7_Scer IYV--------------------TSSPQRIYNELNLLYI------------------MTG CDC7_Hsap LIP--------------------TSHPIRIAAELQCLTV------------------AGG Cdc7_Ddis VAP--------------------TSSPARILNEIHSLLR------------------VGG 7318_Tthe NFQ--------------------TVSPELIFSEIAFLTL------------------LKG Cdc7_Spur IIP--------------------TSHPSRILSELSCLVR------------------IGG CC1G_08833_Ccin IYV--------------------TSGPERIRNELFIMET------------------CRG AqueK154_Aque IIP--------------------TSSTTRIENEIRCLKI------------------MGG CDC7_b_Smoe ALFLSISFGPGLLLTILTGPLQGDKIAASVDKEIKLLKLFGWAYLYSRKISFDVSALHRG CDC7_a_Smoe ALFLCIFFGPGLLLTILTGPLQGDKIAASVDKEIKLLKL------------------FGG GK046_Glam IRL--------------------TAKPHQLLKEIEFLRR------------------LEG : *: : * CG5790_Dmel VENVIGINCCIRYND---NVAFIMPYMTHDRFHDIYR--SLNFPEIRDYLRNLLIALRHV CG8655_Dmel KENVVGIHCCMRYDA---SAAFVMPFMAHDRFQDFYT--RMDVPEIRQYMRNLLVALRHV CDC7_Mmus QDNVMGLKYCFRKND---HVVIAMPYLEHESFLDILN--SLSFQEVREYMYNLFVALKRI C34G6.5_Cele HFNIVKLFEFFHFNG---SVAIVLEHFPHCTATELLFHSKRDLSFALSYFRNLLYAVAYL CDC7_Scer SSRVAPLCDAKRVRD---QVIAVLPYYPHEEFRTFYR--DLPIKGIKKYIWELLRALKFV CDC7_Hsap QDNVMGVKYCFRKND---HVVIAMPYLEHESFLDILN--SLSFQEVREYMLNLFKALKRI Cdc7_Ddis HYNVSALFGALRYKD---QVTLILPFFEHDSFKDYFF--QMSNENIKHYLYALFDSLRHI 7318_Tthe QPCTPQMVDLFTQEE---KTHIVIEYFKYEPFIKFFA--ESNMEEIKHYIYQMLLAVKTL Cdc7_Spur CHNVMGVKLTVREKD---NIVIVMPHFKHNKFQDFYH--DMTVKEVQDYLRALFIALRRV CC1G_08833_Ccin ARHVSQLITAFRHHD---QVAIVMPYHRNEDFRRPTR--MTD-----------------K AqueK154_Aque KDNVIPIHASLRFQD---HTVLILPYFSHDRFIDYLP--TLTAEETRQYMHALFLALRNV CDC7_b_Smoe KHSIIRLEEVIRDGE---KQYLVLEHVEYDSIQSLKK--DISMNDLRSYGFHLFKALNYM CDC7_a_Smoe KHSIIRLEEVIRDGE---KKYLVLEHVEYDSIQSLKK--DISMNDLRSYGFHLFKALNYM GK046_Glam KSHIVQIKEI-RFSDATLQTTVITSYSDTDDFKSVIL--DFTPREIQAYMRSILTALSHL : . CG5790_Dmel HKF-------------------NVIHRDVKP--SNILYNRRTG--------KFLLCDFGL CG8655_Dmel HKF-------------------DVIHRDVKP--SNFLYNRRRR--------EFLLVDFGL CDC7_Mmus HQF-------------------GIVHRDVKP--SNFLYNRRLK--------KYALVDFGL C34G6.5_Cele HHN-------------------GYVHRDIKL--SNFLYSPQTQ--------RFRLVDFGL CDC7_Scer HSK-------------------GIIHRDIKP--TNFLFNLELG--------RGVLVDFGL CDC7_Hsap HQF-------------------GIVHRDVKP--SNFLYNRRLK--------KYALVDFGL Cdc7_Ddis HQN-------------------NICHRDVKP--TNFLYSIKNN--------SFLLIDFGL 7318_Tthe KSM-------------------GIYHRDVKP--GNFLYNTAEK--------KGILIDYGL Cdc7_Spur HKF-------------------NVIHRDVKP--GNFLYNRHSR--------KYALVDFGL CC1G_08833_Ccin HHC-------------------NKIMDDKPPVLGACLHTQPTEQYPHGHIRKKHQYDENL AqueK154_Aque HMH-------------------HIIHRDIKP--SNFLYHRASK--------RFQLIDFGL CDC7_b_Smoe HQK-------------------NVIHRDVKP--GNFLYSRKSK--------VGHLVDFNL CDC7_a_Smoe HQKVGLFFFFFVNTVFTFELLQNIIHRDVKP--GNFLYSRKSK--------VGHLVDFNL GK046_Glam EKL-------------------KIIHRDIKP--GNFLFERKTG--------KGLLIDFGL . * *. * .* CG5790_Dmel AQ-RIAD----------------------------------------------------- CG8655_Dmel AQ-HVNPP---------------------------------------------------- CDC7_Mmus AQ-GTRDTKIELLKFVQSEAQ-----------QEDCSRNKYHGVVGHKGLLSRPAPKTVD C34G6.5_Cele AT-VDRSKNECSRSHAVAA----------------------------------------- CDC7_Scer AE-AQMDY---------------------------------------------------- CDC7_Hsap AQ-GTHDTKIELLKFVQSEAQ-----------QERCSQNKSHIITGNKIPLSGPVPKELD Cdc7_Ddis AQ-EMPNSNSNSNSNSNSNSN-----------SNSNSNSNSNSNNNNNN----------- 7318_Tthe SE-IDDKFIENL-KEQQRQKK-----------D--------------------------- Cdc7_Spur AQ-AVPTRSSAKTTV-KPSTVGGVLHHDTPRPPQARKNTRRAVSTSE------------- CC1G_08833_Ccin VKEGQMDA---------------------------------------------------- AqueK154_Aque AH-HESSSGNKSETRSKGDSK--------------------------------------- CDC7_b_Smoe AL-EQDLAGRAK-RRLPNQNR-----------QMQCSLPADITFTEER------------ CDC7_a_Smoe ------------------------------------------------------------ GK046_Glam AQ-TLREVREFPLLRGQSKSR-----------KGVIHINLDRLMRQS------------- CG5790_Dmel ------------------------------------------------------------ CG8655_Dmel ------------------------------------------------------------ CDC7_Mmus QQCTPKTSV--KRSYT--QVHIKQGKDGK-ERSVGLSVQRSVFGERNFNIHSS------- C34G6.5_Cele ------------------------------------------------------------ CDC7_Scer ------------------------------------------------------------ CDC7_Hsap QQSTTKASV--KRPYTNAQIQIKQGKDGK-EGSVGLSVQRSVFGERNFNIHSS------- Cdc7_Ddis NNNNTNNNF--N--GNNSN----------NDFNNFINMNNSNSNNNNNN-NSNNNNNNNN 7318_Tthe ------------------------------------------------------------ Cdc7_Spur NKALTRVEP--KRTQSESHSKV--PKLVELDPNTFHSTDKSSRDRSNHRLDSV------N CC1G_08833_Ccin ------------------------------------------------------------ AqueK154_Aque ----------------------------------------------LNNIHV-------A CDC7_b_Smoe -NALLQ-------------------------------CSRLEA----------------D CDC7_a_Smoe ------------------------------------------------------------ GK046_Glam NQYLTDLTAQGEETYYTARMSLKEGQ---------------------------------- CG5790_Dmel ------------------------------------------------------------ CG8655_Dmel ------------------------------------------------------------ CDC7_Mmus ---ISHESPA----------EKLIKQSKTVDIIS--RK----L-ATKK--TAISTKAMNS C34G6.5_Cele ------------------------------------------------------------ CDC7_Scer ------------------------------------------------------------ CDC7_Hsap ---ISHESPA----------VKLMKQSKTVDVLS--RK----L-ATKK--KAISTKVMNS Cdc7_Ddis NNNNNNNNNSNNNNNSNNSQEEIILPS------------------TN---EN-------- 7318_Tthe -------------------------------------PEIQ----------KKI------ Cdc7_Spur EDDLKKKVPAMIARGSENTAEVIIAPSKEKKPTKPPKP----VILTRN-CAAIATRGVTR CC1G_08833_Ccin -------------------RKKS-----------------------K------------- AqueK154_Aque AE------P----------------------LRK--RK----L-SSKR--SS-------- CDC7_b_Smoe AE------D----------FDKMLKRLRSADYKS--QEHMQPVQMTRKPLREYVTSNIPS CDC7_a_Smoe ------------------------------------------------------------ GK046_Glam ------TVPA----------AH----------------------VTGS--NAAASTNVVR CG5790_Dmel ----------------------------------DEMHASRAGTPGYRPPEVLLRYPKQS CG8655_Dmel -------------------------------AK-KEVHASRAGTPGYRPPEVLLKYPDQT CDC7_Mmus -VMRETARSCP--AVLTCDCYGSDRVCSVCLSR-RQQVAPRAGTPGFRAPEVLTKCPDQT C34G6.5_Cele -------MERD--P-ECCSCKGTSSPCMFCRGKPKRENYNVVGTPGVRAPELLFGIGLCH CDC7_Scer -----------------------------KSTR-RIKRANRAGTRGFRAPEVLMKCGAQS CDC7_Hsap AVMRKTASSCP--ASLTCDCYATDKVCSICLSR-RQQVAPRAGTPGFRAPEVLTKCPNQT Cdc7_Ddis GTTTSNASSTS--NTTSSSSSSSNKSKNLRNDP-KPQPAPRAGTRGFRAPEVLLKYNKQT 7318_Tthe ------------------DLYQNIKKC-----E-KIVGKNKIGTESFMPLESILRYRDQG Cdc7_Spur -RLQDMPK-TP--Q-GICGCYGLPRVCDVCMAK-KNQVAPRAGTPGFRSPEVLLKCPDQT CC1G_08833_Ccin -----------------MHAHSVGI--LDKDTR-MPMKANRAGTRGFRAPEVLLKCGQQS AqueK154_Aque RSTDERAVSNS--GLLCPTRHSMSEVCGFCLGR-NGQVAARAGTPGFRAPEVLLKCSHQT CDC7_b_Smoe NQARKRVGLKP---TLVTDIKPLATIYPSCSLD-RR-RIACVGTKGYGAPEVLLGSP-QT CDC7_a_Smoe ------------------------------------------------------------ GK046_Glam -PNDDTAERLPIAGYINK---------DHSTFR-PLPPSAHSGTHGYRAPEILVPVRNQD CG5790_Dmel TAVDVWAAGVIMLSLLSGLHPFFKAP----------------------HDCGALAEIINL CG8655_Dmel TAVDVWAAGVIFLSIMSTVYPFFKAP----------------------NDFIALAEIVTI CDC7_Mmus TAIDMWSAGVIFLSLLSGRYPFYKAS----------------------DDLTALAQIMTI C34G6.5_Cele PSIDIFSCGIVLLSLVSVKHPFFMPK----------------------DETENIMHLAFL CDC7_Scer TKIDIWSVGVILLSLLGRRFPMFQSL----------------------DDADSLLELCTI CDC7_Hsap TAIDMWSAGVIFLSLLSGRYPFYKAS----------------------DDLTALAQIMTI Cdc7_Ddis TAIDIWSVGVILLCMISGRYPFFISP----------------------DDMTSLAEIVSI 7318_Tthe YQVDIWPIGVVFLQFLLKKYNIFNNVRMQNKPNQNKNNHNKSGQIKNTYFITFILELANI Cdc7_Spur TAVDMWAAGVIFLSILSGRYPFFRAP----------------------DDFTALAQIMSI CC1G_08833_Ccin GAVDVWSAGIILLFFLTRKFPIFQSN----------------------DDIEALMELAAI AqueK154_Aque TGKEMV------------------------------------------------------ CDC7_b_Smoe VKVDIWSAAVTLLQIATGRLPFSNGG-----------------------VPKTIQEIAKL CDC7_a_Smoe ------------------------------------------------------------ GK046_Glam CKIDSWSVGVILIQILTGKTSLFRGNP--------------------TVDIYEILAIRSI CG5790_Dmel FGDMPVRK---------------------------------------------------- CG8655_Dmel FGDQA------------------------------------------------------- CDC7_Mmus RGSRETIQAAKAFGKSVLCS-KEVPAQDLR---ALCERLRG------------------- C34G6.5_Cele LGSETIEKMAHSEGLRVTLS-EKLPPADYY---HLIL----------------------- CDC7_Scer FGWKELRKCAWSD----------------------------------------------- CDC7_Hsap RGSRETIQAAKTFGKSILCS-KEVPAQDLR---KLCERLRG------------------- Cdc7_Ddis IGTKKIVDIAHLLEKKISIS-HSIPPTPWR---DLSRRLRS------------------- 7318_Tthe FGSDAVIELCRKYEYEVSLP-NELPKGPI------------------------------- Cdc7_Spur MGTEETTEAAKVNGKNLLCN-VKLPAMELK---TMCRQLRL------------------- CC1G_08833_Ccin FGRKKMESVATLHARKFATNVPDIPQDQVK-WTTMIEKLNPDLLTPPTPKEHFYPYTLPS AqueK154_Aque ------------------CC-PDVPAADLK---CLCHALRK------------------- CDC7_b_Smoe CGTRELKELVGTK---KTCF-LEVAVQELK---HDCDGT--------------------- CDC7_a_Smoe ------------------------------------------------------------ GK046_Glam IGTDRFIQGMSRLKADFSLT-AGAPMPQAIALEELAEWY--------------------- CG5790_Dmel ------------------------------------------------------------ CG8655_Dmel ------------------------------------------------------------ CDC7_Mmus -------LD------STTP-RSASGP-PGNASYDP--AASKNTDHKAS-RVQAAQAQHSE C34G6.5_Cele ------------------------------------------------------------ CDC7_Scer ------------------------------------------------------------ CDC7_Hsap -------MD------SSTP-KLTSDI-QGHASHQP--AISEKTDHKASCLVQTPPGQYSG Cdc7_Ddis -----------------------------ESS---------------------------- 7318_Tthe -------------------------------NFK-------------------------- Cdc7_Spur -------GA-----VQRRQ-SKSSQS-NGESSKRRRRSINQTSPPKE-ETVGSPESQRSV CC1G_08833_Ccin YRAKLRQEEERRQQRQQDPHRTPTRSSRHEQSQED--DIESDAAPPTSHLTSSSPLLFPR AqueK154_Aque -------SN------QQTT-SRPTKK-KRPSSPD-------------------------- CDC7_b_Smoe -------------------------------SIS-------------------------- CDC7_a_Smoe ------------------------------------------------------------ GK046_Glam ------------------------------------------------------------ CG5790_Dmel ---------------------------TAPAVAYDLLSRLLEVNPQKRITAEEALKHPFF CG8655_Dmel ----------------------------IPPSAYDLLDRLLEINPHKRITAEEALKHPFF CDC7_Mmus DSLY-KRDNDGYWSHPKDCTSNSEGWDSVPDEAYDLLDKLLDLNPASRITAEAALLHAFF C34G6.5_Cele ---------------------------------------C------LRFGFDHVRRHCSS CDC7_Scer -----------------------------HYWCFQVLEQCFEMDPQKRSSAEDLLKTPFF CDC7_Hsap NSFK-KGDSNSCEHCFDEYNTNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFF Cdc7_Ddis -----------------------CDKQDVPVELYDLLERCLDPNPLTRITASEALLHP-F 7318_Tthe ---------------------EIIKKEEFDDVANDLLTKLIALDQADRISVEDALNHPFF Cdc7_Spur GSV----------------GSEEGLVDQFPDTAYDLLGRLLELDPHKRITAEQALKHPFL CC1G_08833_Ccin SSPANNVDEDSPS---PGSDSLQTSWEQGIRDAMDLVTKLLEPESVKRITPAAALAHPFL AqueK154_Aque ---------------------PEVDPDSFPSSAFDLLYKCLDVNPKTRLTATLALKHPFF CDC7_b_Smoe ---------------------EWIKSPELPSSFLDLISKCLKANPEERISAREAMQHEFF CDC7_a_Smoe -----------------------------------------------------------A GK046_Glam ---------------------NPDLLAVLPASCFDLCRKLLEFDPESRLSATEALSHPFL