CLUSTAL W (1.83) multiple sequence alignment CkIIalpha_Dmel YQLVRKLGRGKYSEVFEAINITTT-EKC-------------------------------- CK2a2_Mmus YQLVRKLGRGKYSEVFEAINITNN-ERV-------------------------------- CK2a1_Mmus YQLVRKLGRGKYSEVFEAINITNN-EKV-------------------------------- CKA2_Scer YEIINKIGRGKYSEVFSGRCIVNN-QKC-------------------------------- CKA1_Scer YEIENKVGRGKYSEVFQGVKLDSK-VKI-------------------------------- CK2a2_Hsap YQLVRKLGRGKYSEVFEAINITNN-ERV-------------------------------- CK2a1_Hsap YQLVRKLGRGKYSEVFEAINITNN-EKV-------------------------------- CK2_Ddis YEIIRKIGRGKYSEVFEGANIKNN-EKC-------------------------------- DDB0219953_Ddis YEVIQKIGRGKYSEVFSGIDIETS-DEV-------------------------------- 15737_Tthe YEVIRKLGRGKYSEVFEGINSLNN-EKC-------------------------------- 28298_Tthe YLVGSKLGSGKFSDVYLGYNKSNNYEKI-------------------------------- 1648_Tthe YEVIRKLGRGKYSEVFDGISVVTK-KRV-------------------------------- CK2a_Spur YQIVRKLGRGKYSEVFEAVNITSN-EKHSRKRWERFVHSENQHLVSPEALDFLDKLLRYD kin-3_Cele YQLVRKLGRGKYSEVFEGFKMSTD-EKV-------------------------------- CC1G_04406_Ccin YEIVRKVGRGKYSEVFEGINVVTE-EKC-------------------------------- AqueK108_Aque FQLVCKLGRGKYSEVFEGISVATN-EKV-------------------------------- CK2-1_Smoe YEVVRKVGRGKYSEVFEGINCVNN-EHC-------------------------------- CK2-2_Smoe YEVVRKVGRGKYSEVFEGINCVNN-EHC-------------------------------- GK027_Glam YEIGRKLGHGKYSDVFEGYCVDTD-SSV-------------------------------- : : *:* **:*:*: . . CkIIalpha_Dmel ------------------------------------------------------------ CK2a2_Mmus ------------------------------------------------------------ CK2a1_Mmus ------------------------------------------------------------ CKA2_Scer ------------------------------------------------------------ CKA1_Scer ------------------------------------------------------------ CK2a2_Hsap ------------------------------------------------------------ CK2a1_Hsap ------------------------------------------------------------ CK2_Ddis ------------------------------------------------------------ DDB0219953_Ddis ------------------------------------------------------------ 15737_Tthe ------------------------------------------------------------ 28298_Tthe ------------------------------------------------------------ 1648_Tthe ------------------------------------------------------------ CK2a_Spur HQERVTAREAMEHPYFYPVVKEQNRSMPPVMSTQPNTSTSATNSSSACTSPCFLFRLHSR kin-3_Cele ------------------------------------------------------------ CC1G_04406_Ccin ------------------------------------------------------------ AqueK108_Aque ------------------------------------------------------------ CK2-1_Smoe ------------------------------------------------------------ CK2-2_Smoe ------------------------------------------------------------ GK027_Glam ------------------------------------------------------------ CkIIalpha_Dmel --------VVKILKPVKKKKIKREIKILENLR---------------------------- CK2a2_Mmus --------VVKILKPVKKKKIKREVKILENLR---------------------------- CK2a1_Mmus --------VVKILKPVKKKKIKREIKILENLR---------------------------- CKA2_Scer --------VIKVLKPVKMKKIYRELKILTNLT---------------------------- CKA1_Scer --------VIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFI CK2a2_Hsap --------VVKILKPVKKKKIKREVKILENLR---------------------------- CK2a1_Hsap --------VVKILKPVKKKKIKREIKILENLR---------------------------- CK2_Ddis --------VIKVLKPVKKKKIKREIKILQNLC---------------------------- DDB0219953_Ddis --------VIKVLKPVQKLKIQREIKILESLN---------------------------- 15737_Tthe --------VIKVLKPIRKKKIKREISILKNLS---------------------------- 28298_Tthe --------LIKILRPNKIEKVQREISILTKVN---------------------------- 1648_Tthe --------VIKVLKPVKKRKIKREIKILQILK---------------------------- CK2a_Spur LALEPLKLAFPLCQPVKKKKIKREIKILENLR---------------------------- kin-3_Cele --------VVKILKPVKKKKIKREIKILENLR---------------------------- CC1G_04406_Ccin --------IIKVLKPVKKKKIKREIKILQNLA---------------------------- AqueK108_Aque --------VIKVLKPVKKKKIKREIKILENLR---------------------------- CK2-1_Smoe --------IIKILKPVKKKKIKREIKILQNLC---------------------------- CK2-2_Smoe --------IIKILKPVKKKKIKREIKILQNLC---------------------------- GK027_Glam --------VIKILKPVRRKKIYREIKILTNLL---------------------------- . : :* : *: **:.** : CkIIalpha_Dmel ----------GGTNIITLLAVVKDPVSRTPALIFEHVNNTDFKQLYQTLTDYEIRYYLFE CK2a2_Mmus ----------GGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYE CK2a1_Mmus ----------GGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYE CKA2_Scer ----------GGPNVVGLYDIVQDADSKIPALIFEEIKNVDFRTLYPTFKLPDIQYYFTQ CKA1_Scer RPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPKLTDLEIRFYMFE CK2a2_Hsap ----------GGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYE CK2a1_Hsap ----------GGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYE CK2_Ddis ----------GGPNIITLYDVVRDPQSKTPSLIFEYINNTDFKHLSPTLTDFDVRYYIRE DDB0219953_Ddis ----------GGPNIIPLLDSVKDQSSKVCSLVFPFVNKTDIRELVYTLDDYDIRYYIFE 15737_Tthe ----------GGPNIVQLLDIVKDPASKCTSFVFEYVNNIDYRELYPKLSDFDVRFYIFE 28298_Tthe ----------SIENVPKFYGITVDKYYQVPSLTI-------------------------- 1648_Tthe ----------GGPNIVELLDVVRDPASKTPSLIFEQIENVDFRSQFPNLTDLEIKFYMFE CK2a_Spur ----------GGPNIIALQAIVKDPVSRTPALIFEYVNNTDFKQLYQTLKDYEIRYYLFE kin-3_Cele ----------GGTNIITLLDVVKDPISRTPALIFEHVNNSDFKQLYQTLSDYDIRYYLYE CC1G_04406_Ccin ----------GGPNIVALLDVVRDPASKIPSLITEYVHNVEFKQLYPRFTDMDVRYYMFE AqueK108_Aque ----------GGPNIINLIDVVKDPWSRTPALVFEHVNNTDFKKLYTSLTDFDIRYYLYE CK2-1_Smoe ----------GGPNIVKLLDIVRDQQSKTPSLIFEYVNNTDFKTLYPTLTDYDIRYYLYE CK2-2_Smoe ----------GGPNIVKLLDIVRDQQSKTPSLIFEYVNNTDFKTLYPTLTDYDIRYYLYE GK027_Glam ----------AGPNCINLLDVVSVRDSDYPALILEHGG-LSLAHSVQMLNDEQIRIVLFQ . * : :: CkIIalpha_Dmel LLKALDYCHSMGIMHRDVKPHNVMIDHENRKLRLIDWGLAEFYHPGQEYNVRVASRYFKG CK2a2_Mmus LLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKG CK2a1_Mmus ILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKG CKA2_Scer LLIALDYCHSMGIMHRDVKPQNVMIDPTERKLRLIDWGLAEFYHPGVDYNVRVASRYHKG CKA1_Scer LLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKG CK2a2_Hsap LLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKG CK2a1_Hsap ILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKG CK2_Ddis LLHALDFCHSNGIMHRDVKPSNVMIDHQKRKLYLIDWGLAEFYHPNQDYNVRVASRPYKG DDB0219953_Ddis LLKAIDYTHSKGIIHRDIKPLNIAIDHSKRKLSLIDWGLAEYYHPGKNYNVRVASRHYKP 15737_Tthe VLKALDFCHSQGIMHRDVKPHNIMIDHEKKQLRLIDWGLAEYYFPGKDYNVRVASRYFKG 28298_Tthe -----YQAHKIGVIHRDIKSANIIINHEKRVLKVIDWGLSDIYFPYSFNFCKIGTVNYKA 1648_Tthe ILKALDYCHSKGIMHRDVKPQNIIVDPKNKILKLIDWGLAEFYHPGTDYNVRVASRYFKG CK2a_Spur LLKALDYSHSMGIMHRDVKPHNVMIDHENRRLRLIDWGLAEFYHPGQEYNVRVASRYFKG kin-3_Cele LLKALDFCHSQGIMHRDVKPHNVMIDAEKRELRLIDWGLAEFYHPRQDYNVRVASRYFKG CC1G_04406_Ccin LLKALDFCHSKGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPKTEYNVRVASRYFKG AqueK108_Aque LLKALDYAHSMGIMHRDVKPHNVMIDHEQRKLRLIDWGLAEFYHPNQEYNVRVASRYFKG CK2-1_Smoe LLKALDHCHSQGIMHRDVKPHNVMIDHEQRKLRLIDWGLAEFYHPGKEYNVRVASRYFKG CK2-2_Smoe LLKALDHCHSQGIMHRDVKPHNVMIDHEQRKLRLIDWGLAEFYHPGKEYNVRVASRYFKG GK027_Glam TLRALEWFHIHGIVHRDTKPGNIAYDPTSHRLKLLDYGLAEFYSYGTPLHHRVASRHYKS * *::*** *. *: : : * ::*:**:: * ::.: .* CkIIalpha_Dmel PELLVDYQM---YDYSLDMWSLGCMLASM---------IFRKEPFFHGHDNYDQLVRIAK CK2a2_Mmus PELLVDYQM---YDYSLDMWSLGCMLASM---------IFRKEPFFHGQDNYDQLVRIAK CK2a1_Mmus PELLVDYQM---YDYSLDMWSLGCMLASM---------IFRKEPFFHGHDNYDQLVRIAK CKA2_Scer PELLVNLNQ---YDYSLDLWSVGCMLAAI---------VFKKEPFFKGSSNPDQLVKIAT CKA1_Scer PELLVDYRM---YDYSLDLWSFGTMLASM---------IFKREPFFHGTSNTDQLVKIVK CK2a2_Hsap PELLVDYQM---YDYSLDMWSLGCMLASM---------IFRREPFFHGQDNYDQLVRIAK CK2a1_Hsap PELLVDYQM---YDYSLDMWSLGCMLASM---------IFRKEPFFHGHDNYDQLVRIAK CK2_Ddis PELLVDMED---YDYSLDMWSLGCMFAGM---------LFQKDPFFHGHDNIDQLVKIVK DDB0219953_Ddis PELLVNMFD---YDYSLDMWSLGCLFAGL---------ILDRDPFFNGDNNNDQLLKIVK 15737_Tthe PELLVDYQY---YDYSLDIWSLGAMFAGM---------IFKKEPFFQGNDNYDQLEKIAR 28298_Tthe PELILTDSYHINITPAVDIWASGVIIFQM---------MINSVPLIKGHNSYTALLDIIK 1648_Tthe PELLVDQNY---YDYSLDIWSTGTMFASMQQTQTQIIKIFKKEPFFQGADNQDQLIKIAK CK2a_Spur PELLVDYQL---YDYSLDMWSLGCMLASM---------IFRKEPFFHGHDNYDQLVRIAK kin-3_Cele PELLVDYQC---YDYSLDMWSLGCMLASM---------IFRKEPFFHGHDNYDQLVRIAK CC1G_04406_Ccin PELLVDFQE---YDYSLDMWSYGCMFASM---------IFRKEPFFHGHDNYDQLVKITK AqueK108_Aque PELLVDLQE---YDYSLDMWSFGCMLASM---------IFKKEPFFHGHDNYDQLVRIGK CK2-1_Smoe PELLVDLQD---YDYSLDMWSLGCMFAGM---------IFRKEPFFYGHDNHDQLVKIAK CK2-2_Smoe PELLVDLQD---YDYSLDMWSLGCMFAGM---------IFRKEPFFYGHDNHDQLVKIAK GK027_Glam PEILVNYQL---YDYSLDIWSLGTLAAGL---------IFKRHPFFRGTNNINQLDKIVE **::: ::*:*: * : : :: *:: * .. * * CkIIalpha_Dmel VLGTEELYAYLDKYNIDLDPRFHDILQ-----RHSRKRWERFVHSDNQHLVS-PEALDFL CK2a2_Mmus VLGTDELYGYLKKYHIDLDPHFNDILG-----QHSRKRWENFIHSENRHLVS-PEALDLL CK2a1_Mmus VLGTEDLYDYIDKYNIELDPRFNDILG-----RHSRKRWERFVHSENQHLVS-PEALDFL CKA2_Scer VLGTKELLGYLGKYGLHLPSEYDNIMR-----DFTKKSWTHFITSETK-LAV-PEVVDLI CKA1_Scer VLGTSDFEKYLLKYEITLPREFYDM-D-----QYIRKPWHRFINDGNKHLSGNDEIIDLI CK2a2_Hsap VLGTEELYGYLKKYHIDLDPHFNDILG-----QHSRKRWENFIHSENRHLVS-PEALDLL CK2a1_Hsap VLGTEDLYDYIDKYNIELDPRFNDILG-----RHSRKRWERFVHSENQHLVS-PEALDFL CK2_Ddis ILGTEEFYAYLDKYGIVVDHTILSIIG-----KHPKKPWSRFITKENQHLAV-PEAIDFL DDB0219953_Ddis VLGTDDLFNFLDKFGLSLTDEQSSLIK-----PRQKSNWERFIPYENDDIAQ-PDAIDFL 15737_Tthe VLGTNELYDYLNTYNLELDPKFEGILG-----KHTKKPWSKFVNNDNKNLAV-NEAIDLL 28298_Tthe IFGYKDVMRLSSWSGIPLNPQIYKEIQENKIYTEKGKGLKQLIDQDNVKYAD-PLGLDLI 1648_Tthe VLGTEDLHKYLRKYDLTLDVSYHKILG-----SYAKKPWVKFITEENKHLCH-EQAIDLL CK2a_Spur VLGTDELYEYLDKYQIELDPRFNDILG-----RHSRKRWERFVHSENQHLVS-PEALDFL kin-3_Cele VLGTDELYEYIARYHIDLDPRFNDILG-----RHSRKRWERFIHAENQHLVT-PEALDFL CC1G_04406_Ccin VLGTDDLYAYIEKYNIRLDSQYDEILG-----RYPRKPWTRFITSENQRYIS-NEAIDFL AqueK108_Aque VLGTEELYEYIDRYKIDLDPRFSDTLG-----RHSRKRWERYVHGENQHLVS-REALDLL CK2-1_Smoe VLGTDELNAYLNKYHLELDAHFESMVG-----RHSRKPWSKFINNDNQHLVN-PEALDFL CK2-2_Smoe VLGTDELNAYLNKYHLELDAHFESMVG-----RHSRKPWSKFINNDNQHLVN-PEALDFL GK027_Glam VLGSADFFAMINKYNIKLSSSRTYDLQ-----GYERMQFDAFTNHDNHYLVT-DQALDFL ::* :. : : . :*:: CkIIalpha_Dmel DKLLRYDHVDRLTAREAMAHPYF CK2a2_Mmus DKLLRYDHQQRLTAKEAMEHPYF CK2a1_Mmus DKLLRYDHQSRLTAREAMEHPYF CKA2_Scer DNLLRYDHQERLTAKEAMDHKFF CKA1_Scer DNLLRYDHQERLTAKEAMGHPWF CK2a2_Hsap DKLLRYDHQQRLTAKEAMEHPYF CK2a1_Hsap DKLLRYDHQSRLTAREAMEHPYF CK2_Ddis EKLLRYDPAERLTTREAMEHPYF DDB0219953_Ddis DKLLRYDPTERLTAKEAMKHPYF 15737_Tthe SKMLVYDHAQRITPKEAMQHAYF 28298_Tthe DKMLKILPNERISAKEALDHPYF 1648_Tthe SKMLIYDNALRITPKDAMEHPYF CK2a_Spur DKLLRYDHQERVTAREAMEHPYF kin-3_Cele DKLLRYDHAERLTAQEAMGHEYF CC1G_04406_Ccin DKLLRYDHQDRLTAREAQMQPYF AqueK108_Aque DKLLRYDHRERLSAKEAMGHPYF CK2-1_Smoe DKLLRYDHQERLTAREAMAHAYF CK2-2_Smoe DKLLRYDHQERLTAREAMAHAYF GK027_Glam NKTLVYDPEKRLTVREALLHPYF .: * *:: ::* : :*