CLUSTAL W (1.83) multiple sequence alignment PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 KQ---------------------------------------------------------- DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 KHKHKSKKSHHKHKHHKENKDGHRRHKHKHKKHKSKKDEEPPVATPAADESESDIELEDT CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 IPLPKFEPKIPPPPPPPNSRRESGRKERGRGGDDTLAALEKQKELLQAQLLATAEDEHSG CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 MNLIAQGYQSDEEEGEDDESALKQSLSKWIRPESSSSKPSSKSELKDSERSEKRKRERED CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ETSQKKQHRSKSPATERSSGSSRVDNGDAKSSQSRTNRDSHIASDRKHSKDSDSRRDSRK CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 SSPSATKSEQRESRDSREPRDSRKSSGRDGRASPKRELKSGEKSRRESSRDSKPIRSRSP CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 -----------------------------GRVDDAKDKSRKRKSVEDEQPSSKRREDDDG PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 KKERVFTEPARSRPSPPRRSPPPRRPPSPPARRPDQPLGRRGRSPIERRGRSPLERRIRS CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 KRKHKHRKHKHRSSHRKHISKEVDLDVVPAAMACEAEDGEILEPTEDGIVLKEEGNGSSE PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 SRSPAVVDRFDRRRGASPPRRFGDMSRNRRRWSRSPDRRGRRGRWGRSRSKSPRDKFKGS CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 SEKDVEQEIEAPKSERGSPRRSRDGSPPRDNVDRKHSSPDRRHRGSSVDRKRRSRSKESV PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 LSEGLSLKQESSDDEIPDVDLDEEEDEEAVIERRRRERQQLMQKYKVAPAESATSSPAQG CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 RENARHHSRVASPDRKRRRSRSRDRGDERSRRHAYSPDRRRRSRSREHDEREKYPRKRAE PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 PSEPSSTPQSPQASEQGGSTAQSQDTDDEDDDEEEEEEDEEEDDSEKSSSSDSDDDSSEV CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 SRDRHIKDDRGARDDERHYNRDRNRRDREELSEKQETTQSETIEREEENQDEYLERVAHQ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ESKASSDDDDDDEEDDEGDAARIEEEERLREEEEEAEQEKRREMERKRLKEAFPQSDSED CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 LAEQEEDIEKVKEESRKRRQAILEKHKMQQSQPEEPAETMKVSKPLTAAEPDSGEGIIDP PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 EESAANSKKGEGSLDKNLSDIVKPKSDKEQAMANNGLDMFSEVDMFKMSPSTREGIGQMG CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 STPLSLGKSALPNGTILKRNAGGLGEGSPPKSEKPADMFCDIFGESPAEIRKAGTRDTLA PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 --------------------KKKEDGELSGEEDEYKSPKQKKSDKDDRKKSKRSSRSHSS DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 PENPSLTDNWDDEEGYYRVRI--------------------------------------- CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------VHPLDELGFSQGRKSSQTHNDQKHKGAARHKSMEARSERSGPESTDEPQVSNIR PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 IDTSGLTDNWDDADGYYTYRV--------------------------------------- PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 RRTNDKISDSTKSNKKDKDHKDSSRRRSKSRSKDRKDQQKRKYSRSRSRSYPNDRNGTKQ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP STRKEAAEDGKPEESCLASRPTSSANSSNQKGGQDKARGSGDGSERSSGFPRLPPVRLKS PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 RHLDNLYQRTQIKNGKCNQIYGSQKRNTKFSNDKFLFSNSKNLSEAFYIDSYFYSLNSSK DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP VEKIPDEWVAHCRVGSDADVEMDPLDASSFALGSFLDVPVGQDILSSGTKRCAAINRPSV PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 KDKDRDNAKEKDRKRSKSPTKDKDRKNDRKRSKSPRSSNNGKRKSSRSKSPKREDSRRDK DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP SHGIVEDPSASFANAGDGSAAEYPDEYWDSDAYEDDDDPGYTRRPIDDEKEFLASEINYP PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 DSKSGYRDNEKKSNYGSNRDRESRRSEENNTRESKQLTLEEEEERNDRYYNDFDDSDSDY DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP SEEERARIEHNPAQQGTTYGKYDDDDRSYVESYFSGEEYYRGRDARDNNGDADVDALCGA PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 YQRVNDRKYKSSRRSKSRSKNRDRKKSKSKGRKDDKNKDKDKERSKNSGNGDNSKSSKDK DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ADELSFRPHANDYDGQLLDSEELKQIRSEPAWQGFVVQGNAIRKDQAATTANDQDDFSRE PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 KEEEAKKAQQPETIDDDEDLNMEIEDSDDERERKKQEFLNMIKVQGMQMQKQEASQTFSK DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP IRETYLAESSDGEVGSLQDCDFQGRNGFLDVEKRRQQCFKQGGPSSAEEEHDIVLQYYNR PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ENNQNNQTQNKNDQDVVDDKLKVKDSENLENQNFADENSEEQLFDDTGLNPNDVLDDDDV DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP PWGHKAQANGCEEVDRNGSVETQLAEEQLGAFQFGGFSFPSPSSAGDVDGSRAESGRSLW PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 NIANTINDDYKEEVDESHSLTHRHSIDKAQLDHLKFLEDMRNQEIKGGIPDMPEQPILKQ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP STREISSRGEEVDQFANGFVGPDDTLASWKRKSNESSPIISGGEDHELRLALSTHSTVSP PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 KRKSINSEKLEGKFSNNDQLDEENKLHKLDDQEDSEEETDMFGDDIDKIINKSNDGKLQI DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP GSTEDSLSVEEERVDDEDVDAQRDETEAAAAYDEEAIAVHEHFHRLQAEEEEFETFDLKI PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 --------------------------YNVYGYTG-QGVFSNVVRARDNAR---------- HIPK4_Hsap_HIPK --------------------------YDIIEVLG-KGTFGEVAKGWRRS----------- HIPK3_Hsap_HIPK --------------------------YEVLDFLG-RGTFGQVVKCWKRG----------- HIPK2_Hsap_HIPK --------------------------YEVLEFLG-RGTFGQVVKCWKRG----------- HIPK1_Hsap_HIPK --------------------------YEVLEFLG-RGTFGQVAKCWKRS----------- smi35A_Dmel_DYRK2 --------------------------YEILEVIG-KGSFGQVIRALDHK----------- mnb_Dmel_DYRK1 --------------------------YEIDSLIG-KGSFGQVVKAYDHE----------- Dyrk3_Dmel_DYRK2 --------------------------YEMLKIIG-KGSFGQVIKAYDHK----------- CG17090_Dmel_HIPK --------------------------YEVLEFLG-RGTFGQVVKCWKRG----------- PRP4_Mmus_PRP4 --------------------------YNVYGYTG-QGVFSNVVRARDNAR---------- HIPK4_Mmus_HIPK --------------------------YDIIEVLG-KGTFGEVAKGWRRS----------- HIPK3_Mmus_HIPK --------------------------YEVLDFLG-RGTFGQVVKCWKRG----------- HIPK2_Mmus_HIPK --------------------------YEVLEFLG-RGTFGQVVKCWKRG----------- HIPK1_Mmus_HIPK --------------------------YEVLEFLG-RGTFGQVAKCWKRS----------- DYRK4_Mmus_DYRK2 --------------------------YEVLEMIG-KGSFGQVAKCLDHK----------- DYRK3_Mmus_DYRK2 --------------------------YEVLKIIG-KGSFGQVARVYDHK----------- DYRK2_Mmus_DYRK2 --------------------------YEVLKVIG-KGSFGQVVKAYDHK----------- DYRK1B_Mmus_DYRK1 --------------------------YEIDSLIG-KGSFGQVVKAYDHQ----------- DYRK1A_Mmus_DYRK1 --------------------------YEIDSLIG-KGSFGQVVKAYDRV----------- mbk-2_Cele_DYRK2 --------------------------YEVLKVIG-KGSFGQVIKAFDHK----------- mbk-1_Cele_DYRK1 --------------------------ILSDTPVG-KGSFGQVTKAYDTL----------- hpk-1_Cele_HIPK --------------------------YEVLEFLG-KGTFGQVVKAWKKG----------- F22D6.5_Cele_PRP4 --------------------------YRVVGFTG-AGVFGNVCRCNDQT----------- C36B7.2_Cele_DYRK2 --------------------------YTIDKVIG-QGCYGVVGEATDGK----------- C36B7.1_Cele_DYRK2 --------------------------YSIDEVLS-SGYYAQVFRCTDKK----------- DYRK4_Hsap_DYRK2 --------------------------YEVLETIG-KGSFGQVAKCLDHK----------- DYRK3_Hsap_DYRK2 --------------------------YEVLKIIG-KGSFGQVARVYDHK----------- DYRK2_Hsap_DYRK2 --------------------------YEVLKVIG-KGSFGQVVKAYDHK----------- DYRK1B_Hsap_DYRK1 --------------------------YEIDSLIG-KGSFGQVVKAYDHQ----------- DYRK1A_Hsap_DYRK1 --------------------------YEIDSLIG-KGSFGQVVKAYDRV----------- YAK1_Scer_YAK --------------------------YLVLDILG-QGTFGQVVKCQNLL----------- Dyrk1_Ddis_DYRK1 --------------------------FEIISSLG-KGSFGQVVKAFDSV----------- Dyrk2_Ddis_DYRK2 --------------------------FEIVSILG-QGSFCQVVKGYDYK----------- Prp4_Ddis_PRP4 --------------------------YQIFSPIG-SGVFSTVVSAKETKT---------- YakA_Ddis_YAK --------------------------YKVLDSLG-QGTFGQVVKCKNCD----------- 22349_Tthe_YAK --------------------------YIIEDMLG-KGTFGQVAKCSKNG----------- 10580_Tthe_DyrkP --------------------------YQIMEYLG-SAAFSKAIQCQDKQ----------- 22423_Tthe_DyrkP --------------------------YQVMEYLG-SAAFSKAIQCLDLV----------- 5306_Tthe_DYRK2 --------------------------YEIKEFLG-KGSFGQVLKVFDHK----------- 5356_Tthe_DYRK2 --------------------------YELIEALG-KGSFGQVIKVFDHK----------- 5655_Tthe_DYRK2 --------------------------YELLECLG-KGSFGSVVKVFDHK----------- 15575_Tthe_PRP4 VKGANAECDDEQNYFKILIGEVLNGKYRVIQKCG-KGVFANVCKAEQLD----------- DYRK1_Spur_DYRK1 --------------------------YEIDSLIG-KGSFGQVAKAYDHQ----------- DYRK2_Spur_DYRK2 --------------------------YEVLKILG-KGSFGQVVKVYDHK----------- DYRK4_Spur_DYRK2 --------------------------YEILEVIG-KGSFGQVVKAFDHK----------- HIPKa_Spur_HIPK --------------------------YEVLEFLG-RGTFGQVVKCWKRG----------- HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 -------------------GESLDKRYAVYGYTG-QGVFSNVVRARDTAR---------- CG7028_Dmel_PRP4 --------------------------YLVNGYTG-QGVFSNVVRGRDQAR---------- CC1G_13957_Ccin_DYRK2 --------------------------YEVVDTLG-KGSFGQVLNCRDHC----------- CC1G_04865_Ccin_PRP4 --------------------------YQVFSSLG-QGMFANVVRARVLKDENGKDLAVDG CC1G_14245_Ccin_YAK --------------------------YLILDILG-QGTFGQVVKCQNMK----------- AqueK110_Aque_DYRK1 --------------------------R--------------------------------- AqueK111_Aque_DYRK1 --------------------------YEIDSLIG-KGSFGQVVKAFDLE----------- AqueK112_Aque_DYRK2 --------------------------YEIREIIG-KGSFGQVVKVFDHK----------- AqueK113_Aque_DYRK2 --------------------------YEVLKVLG-KGSFGQVLKAYDHK----------- AqueK114_Aque_HIPK --------------------------YDVLDRLG-RGTFGQVVRAWKKN----------- AqueK115_Aque_PRP4 --------------------------YMVYGYTG-QGVFSNVVRARDTSR---------- AqueK116_Aque_PRP4 --------------------------YMVYGYTG-HGVFSNVVRARDTSR---------- DYRK2_b_Smoe_DYRK2 --------------------------YEILGKLG-RGSFGQVLKCTDHK----------- DYRK2_a_Smoe_DYRK2 --------------------------YEILGKLG-RGSFGQVLKCTDHK----------- DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP IHRKNRTGFEEDKDFQVLINSVIAGRYHVTEFLG-AAAFSKAIQAHDLF----------- PRP4_e_Smoe_PRP4 --------------------------YQVKASIG-SGMFSTVFLAKSLFP---------- PRP4_d_Smoe_PRP4 --------------------------YQVKASIG-SGMFSTVFLAKSLLP---------- PRP4_b_Smoe_PRP4 --------------------------YEIASSHG-RGVFSTVVRARDTKAGR-------- PRP4_a_Smoe_PRP4 -------------------GEVLDNRYEIASSHG-RGVFSTVVRARDTKAGR-------- PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK --------------------------YVVKEMLG-QGTFGQVVKCWSDR----------- YAK_a_Smoe_YAK --------------------------YVVKEMLG-QGTFGQVVKCWSDR----------- YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 --------------------------YCAERPLG-QGSFGRVVLAKDTV----------- GK034_Glam_DYRK2 --------------------------YELVSKLG-SGSFGKVYKALDHK----------- GK033_Glam_DYRK2 --------------------------YKLLKMVG-SATFSNVFSCLDLK----------- GK032_Glam_DYRK2 --------------------------YEIYKTIFEDSAFSVTLKARDLK----------- PRP4_Hsap_PRP4 ----ANQEVAVKIIRNNELMQKTGLKELEFLKKLND-AD---P-DDKFHCLRLFRHFYHK HIPK4_Hsap_HIPK ----TGEMVAIKILKNDAYRNRIIKNELKLLHCMRG-LDPE-----EAHVIRFLEFFHDA HIPK3_Hsap_HIPK ----TNEIVAIKILKNHPSYARQGQIEVSILARLST-ENAD-----EYNFVRAYECFQHR HIPK2_Hsap_HIPK ----TNEIVAIKILKNHPSYARQGQIEVSILARLST-ESAD-----DYNFVRAYECFQHK HIPK1_Hsap_HIPK ----TKEIVAIKILKNHPSYARQGQIEVSILSRLSS-ENAD-----EYNFVRSYECFQHK smi35A_Dmel_DYRK2 ----TNTHVAIKIIRNKKRFLNQAVVELNILDELRE-KDAD----GSHNVIHMLDYTYFR mnb_Dmel_DYRK1 ----EQCHVAIKIIKNKKPFLNQAQIEVKLLEMMNR-ADAE----NKYYIVKLKRHFMWR Dyrk3_Dmel_DYRK2 ----THEHVALKIVRNEKRFHRQAQEEIRILHHLRR-HDKY----NTMNIIHMFDYFTFR CG17090_Dmel_HIPK ----TSEIVAIKILKNHPSYARQGQIEVSILSRLSQ-ENAD-----EFNFVRAFECFQHK PRP4_Mmus_PRP4 ----ANQEVAVKIIRNNELMQKTGLKELEFLKKLND-AD---P-DDKFHCLRLFRHFYHK HIPK4_Mmus_HIPK ----TGEMVAIKILKNDAYRSRIIKNELKLLRCVRG-LDPD-----EAHVIRFLEFFHDA HIPK3_Mmus_HIPK ----TNEIVAIKILKNHPSYARQGQIEVSILARLST-ENAD-----EYNFVRAYECFQHR HIPK2_Mmus_HIPK ----TNEIVAIKILKNHPSYARQGQIEVSILARLST-ESAD-----DYNFVRAYECFQHK HIPK1_Mmus_HIPK ----TKEIVAIKILKNHPSYARQGQIEVSILSRLSS-ENAD-----EYNFVRSYECFQHK DYRK4_Mmus_DYRK2 ----NNELVALKIIRNKKRFHHQALVELKILEALRR-KDKD----NNHNVVHMKDFFYFR DYRK3_Mmus_DYRK2 ----LRQYVALKMVRNEKRFHRQAAEEIRILEHLKK-QDKT----GSMNVIHMLESFTFR DYRK2_Mmus_DYRK2 ----VHQHVALKMVRNEKRFHRQAAEEIRILEHLRK-QDKD----NTMNVIHMLENFTFR DYRK1B_Mmus_DYRK1 ----TQELVAIKIIKNKKAFLNQAQIELRLLELMNQ-HDTE----MKYYIVHLKRHFMFR DYRK1A_Mmus_DYRK1 ----EQEWVAIKIIKNKKAFLNQAQIEVRLLELMNK-HDTE----MKYYIVHLKRHFMFR mbk-2_Cele_DYRK2 ----YQQYVALKLVRNEKRFHRQADEEIRILDHLRR-QDSD----GTHNIIHMLDYFNFR mbk-1_Cele_DYRK1 ----NKEEVAIKIIKNKKTFFDQAQIEIHLLELTNA-HDKD----NKYNIVTLKGHFVHR hpk-1_Cele_HIPK ----TSEIVAIKILKKHPSYARQGQIEVSILSRLSN-ENSE-----EFNFVRAFECFNHK F22D6.5_Cele_PRP4 ----KGNTVAVKIIRNNEVMYKTGLRELEVLRKLNE-AD---K-EDKYHCLRLFRTFKHH C36B7.2_Cele_DYRK2 ----TKQKVAIRMVSKL---APRIYRETEMIMYISS-ID---P-DHTFDCVRMLDYNVFR C36B7.1_Cele_DYRK2 ----TDKKVCIKLKNRN---LSTTYEETIILLRIHQ-LN---R-QNNSNCVRMLDYDHFR DYRK4_Hsap_DYRK2 ----NNELVALKIIRNKKRFHQQALMELKILEALRK-KDKD----NTYNVVHMKDFFYFR DYRK3_Hsap_DYRK2 ----LRQYVALKMVRNEKRFHRQAAEEIRILEHLKK-QDKT----GSMNVIHMLESFTFR DYRK2_Hsap_DYRK2 ----VHQHVALKMVRNEKRFHRQAAEEIRILEHLRK-QDKD----NTMNVIHMLENFTFR DYRK1B_Hsap_DYRK1 ----TQELVAIKIIKNKKAFLNQAQIELRLLELMNQ-HDTE----MKYYIVHLKRHFMFR DYRK1A_Hsap_DYRK1 ----EQEWVAIKIIKNKKAFLNQAQIEVRLLELMNK-HDTE----MKYYIVHLKRHFMFR YAK1_Scer_YAK ----TKEILAVKVVKSRTEYLTQSITEAKILELLNQKID---P-TNKHHFLRMYDSFVHK Dyrk1_Ddis_DYRK1 ----LKEYVAIKIIKNKVPFYNQALIEIRLLELMNN-KDPE----DQYKIIKLKHHFKFR Dyrk2_Ddis_DYRK2 ----TGEMVALKILRNQKRFHNQALTEIKILEYLKT-NDPN----STASIVHLNNYFYFR Prp4_Ddis_PRP4 -----NEDVVIKIIRNRPSMHRSGLKEIEILQKISN-TPTS-S-NQKSHCIQMKDHFNYR YakA_Ddis_YAK ----TDELVAIKILKNKQAYFQQGRLEIQTLKSLNDQHD---P-EDKNHILRLLDSFIHK 22349_Tthe_YAK ----TNDLFAVKVIKNRPAYFQQAKNEILLLRVLNK-QEEQNGENYQKRIVNLVDFFVFR 10580_Tthe_DyrkP ----TGQMLCMKIIENNKDYFDQSIDEIKLLKYINY-NG---D-VDEKNVLKVYDYFYHK 22423_Tthe_DyrkP ----TNRVMCMKIIENNKDYFDQSIDEIKLLRYINY-NG---D-VDEKNVLRYFDYFYHK 5306_Tthe_DYRK2 ----RKEYAALKVIRNKQKFHEQALIELNILHYIKE-KDYD----NQTNIVKIRDFVIFR 5356_Tthe_DYRK2 ----RKEYSALKIIRNKKNFYNQAIVELNILKYIKD-NDPQ----NQTNIVKIKDFVIFR 5655_Tthe_DYRK2 ----RKEFLALKVIRNKKKFHNQALIELNILSYIKE-QDKD----EATNIVRIKDFVIFR 15575_Tthe_PRP4 ----NGKMVAIKILRSNEIMRDSGEREKEIIQKLNL-ND---K-NDRKHIVRLKNVFEHQ DYRK1_Spur_DYRK1 ----EQEYVAIKIIKNKKPFLNQAQIEVRLLELMNK-HDAD----SKYYIVKLKRHFMFR DYRK2_Spur_DYRK2 ----TNQHIAVKMVRNEKRFHRQAQEEIRILEHLRK-QDKD----NNMNLIHMFESFSFR DYRK4_Spur_DYRK2 ----LGEMIAIKIIRNKKRFHHQALIEVKILDALRR-KDRD----NSHNVVHMREYFYYR HIPKa_Spur_HIPK ----TNEIVAIKILKNHPSYARQGQIEVSILARLSA-ENAD-----DFNLVRAYEYFQHK HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ----GKLDVAIKIIRNNDLMQKTGMKELEYLKRLND-QD---R-EDKFHCVRLFRSFSYR CG7028_Dmel_PRP4 ----GQANVAIKIIRNNEIMHKTGLRELEILKKLND-AD---P-EDRFHCLRLYRHFFHK CC1G_13957_Ccin_DYRK2 ----TGESVAVKIIRNKKRFHHQALVEIKILDNLRK-WDAD----EKHHVLKMTEHFYFR CC1G_04865_Ccin_PRP4 VAPESLREVAIKIIRSQESMYKAGLKEAQILQKLRA-LD---P-EDKKHIVKLERTFEHR CC1G_14245_Ccin_YAK ----THEIVAVKVIKNKPAYFNQSMMEVTILEMLNKTCD---P-NDEHHLLRLRDSFIHR AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ----EREWVAIKVIKNKRAFYQQALIEKRLLELLNS-RDPE----GKYYIVSLKRSFTFR AqueK112_Aque_DYRK2 ----TNQHIALKIIRNKKRFHHQALVEVKILDSLRK-RDRD----NQYNIIHMFDYFYFR AqueK113_Aque_DYRK2 ----MQTHIALKVVRNEKRFHRQAQEEVKILEHLRR-QDKD----NAHNIIHMIDHFTFR AqueK114_Aque_HIPK ----TSEIVAIKILKSTPSYAKQGQMEVDVLSKLSR-LSPD-----EGSFVKAYESFQHH AqueK115_Aque_PRP4 ----SSQEVAIKIIRNNEMMHKTGMAELEILKKLNA-TD---P-DDKFHCIRLFSNFFHK AqueK116_Aque_PRP4 ----SSQEVAIKIIRNNEMMHKTGMAELEILKKLNA-TD---P-DDKFHCIRLFSNFFHK DYRK2_b_Smoe_DYRK2 ----YKVPRAIKIIRNKKQFTQQAFIEINLLEFLRN-KAAE-E-GVDYNIVTIYESFEFR DYRK2_a_Smoe_DYRK2 ----YKVPRAIKIIRNKKQFTQQAFIEINLLEFLRN-KAAE-E-GVDYNIVTIYESFEFR DYRKP-2_Smoe_DYRKP ----------MKIIKNNKDFFDQSLDEIKLLKYINK-HD---P-ADKYHILRLYDYFYHR DYRKP-1_Smoe_DYRKP ----TGMDVCMKIIKNNKDFFDQSLDEIKLLKYINK-HD---P-ADKYHILRLYDYFYHR PRP4_e_Smoe_PRP4 ---ECEQEVAIKIPRKNDLMLRSAKSELQILKKVAE-PEAT---NKDNHCVKLLDSFVYR PRP4_d_Smoe_PRP4 ---ECQQEVAIKIPRKNDLMLRSAKSELQILKKVAE-PEAT---NKDNHCVKLLDSFVYR PRP4_b_Smoe_PRP4 ---GEPEEVAIKIIRSNETMFKAGQMELIILNKLAG-AD---L-ENKRHCVRLLSSFEYR PRP4_a_Smoe_PRP4 ---GEPEEVAIKIIRSNETMFKAGQMELIILNKLAG-AD---L-ENKRHCVRLLSSFEYR PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ----ENGYVAVKVIKNQPAYYQQALVEIEILKMLNRDFD---P-DNQHHIVRILDWFLFE YAK_a_Smoe_YAK ----ENGYVAVKVIKNQPAYYQQALVEIEILKMLNRDFD---P-DNQHHIVRILDWFLFE YAK_d_Smoe_YAK -------IVTRKTVDDK------------------------------------------- GK031_Glam_DYRK1 ----NNAYVAIKIMKAGKLFTHKGREEAEIMSLLSD-ED---P-PIS---CKFIESFMQG GK034_Glam_DYRK2 ----EQQFVALKIIKNRKRFQRQGLVEVKILELLRD-NDPN----GDQCCVKVLSSFYFR GK033_Glam_DYRK2 ----DNVTYCLKIIKQEKEFFDQAIDEVHLLELLKD-ID---P-NNNINIIKIHDYFYFR GK032_Glam_DYRK2 ----EGKDVCLKVVNNEKDTLDQCLNEIRLLTYINK-HD---P-TGK-HFVRMTDYFYYG PRP4_Hsap_PRP4 QHLCLVFEPLSMNLREVLKKYGKD-------VG----LHIKAVRSYSQQLFLALKLLKR- HIPK4_Hsap_HIPK LKFYLVFELLEQNLFEFQKE-NNF-------AP----LPARHIRTVTLQVLTALARLK-- HIPK3_Hsap_HIPK NHTCLVFEMLEQNLYDFLKQ-NKF-------SP----LPLKVIRPILQQVATALKKLK-- HIPK2_Hsap_HIPK NHTCLVFEMLEQNLYDFLKQ-NKF-------SP----LPLKYIRPVLQQVATALMKLK-- HIPK1_Hsap_HIPK NHTCLVFEMLEQNLYDFLKQ-NKF-------SP----LPLKYIRPILQQVATALMKLK-- smi35A_Dmel_DYRK2 KHLCITFELMSLNLYELIKK-NNY-------NG----FSMSLIRRFCNSIVKCLRLLY-- mnb_Dmel_DYRK1 NHLCLVFELLSYNLYDLLRN-TNF-------RG----VSLNLTRKFAQQLCTALLFLSTP Dyrk3_Dmel_DYRK2 NHTCITFELLSINLYELIKK-NGF-------KG----FSLQLVRKFAHSLLQCLDALY-- CG17090_Dmel_HIPK NHTCLVFEMLEQNLYDFLKQ-NKF-------SP----LPLKYIRPILEQVLTALLKLK-- PRP4_Mmus_PRP4 QHLCLVFEPLSMNLREVLKKYGKD-------VG----LHIKAVRSYSQQLFLALKLLKR- HIPK4_Mmus_HIPK LKFYLVFELLEQNLFEFQKE-NNF-------AP----LPARHIRTVTLQVLRALARLK-- HIPK3_Mmus_HIPK NHTCLVFEMLEQNLYDFLKQ-NKF-------SP----LPLKVIRPVLQQVATALKKLK-- HIPK2_Mmus_HIPK NHTCLVFEMLEQNLYDFLKQ-NKF-------SP----LPLKYIRPVLQQVATALMKLK-- HIPK1_Mmus_HIPK NHTCLVFEMLEQNLYDFLKQ-NKF-------SP----LPLKYIRPILQQVATALMKLK-- DYRK4_Mmus_DYRK2 NHLCITFELLGINLYELMKN-NSF-------HG----FNLSIVRRFTFSILKCLHMLY-- DYRK3_Mmus_DYRK2 NHVCMAFELLSIDLYELIKK-NKF-------QG----FSVQLVRKFAQSILQSLDALH-- DYRK2_Mmus_DYRK2 NHICMTFELLSMNLYELIKK-NKF-------QG----FSLPLVRKFAHSILQCLDALH-- DYRK1B_Mmus_DYRK1 NHLCLVFELLSYNLYDLLRN-THF-------RG----VSLNLTRKLAQQLCTALLFLATP DYRK1A_Mmus_DYRK1 NHLCLVFEMLSYNLYDLLRN-TNF-------RG----VSLNLTRKFAQQMCTALLFLATP mbk-2_Cele_DYRK2 NHKCITFELLSINLYELIKR-NKF-------QG----FSLMLVRKFAYSMLLCLDLLQ-- mbk-1_Cele_DYRK1 AHLCLVFELLSYNLYDLLKN-TSF-------RG----VSLNLARKFAQQLGKTLLFLSSP hpk-1_Cele_HIPK SHTCLVFEMLEQNLYDFLKQ-NKF-------MP----LPLNAIRPILFQVLTALLKLK-- F22D6.5_Cele_PRP4 NHLCLVFENLSMNLRELLKKYGQK-------DG----LHLKAVRSYAQQLLLALRLLKK- C36B7.2_Cele_DYRK2 GFHYVVTDLFDTSVKKYIKE-HHP-------NG----IALENVAAMGRKILKGLVFLHE- C36B7.1_Cele_DYRK2 GHHFIVLENYQTDLASYLCGRSKL-------T-------PREYIPMIKSIVHGLKFLHQ- DYRK4_Hsap_DYRK2 NHFCITFELLGINLYELMKN-NNF-------QG----FSLSIVRRFTLSVLKCLQMLS-- DYRK3_Hsap_DYRK2 NHVCMAFELLSIDLYELIKK-NKF-------QG----FSVQLVRKFAQSILQSLDALH-- DYRK2_Hsap_DYRK2 NHICMTFELLSMNLYELIKK-NKF-------QG----FSLPLVRKFAHSILQCLDALH-- DYRK1B_Hsap_DYRK1 NHLCLVFELLSYNLYDLLRN-THF-------RG----VSLNLTRKLAQQLCTALLFLATP DYRK1A_Hsap_DYRK1 NHLCLVFEMLSYNLYDLLRN-TNF-------RG----VSLNLTRKFAQQMCTALLFLATP YAK1_Scer_YAK NHLCLVFELLSNNLYELLKQ-NKF-------HG----LSIQLIRTFTTQILDSLCVLK-- Dyrk1_Ddis_DYRK1 NHLCIVTELLSYNLYDLLRN-THF-------HG----VSLNLIKKFAHQILTALFFMSTP Dyrk2_Ddis_DYRK2 NHLILTFELLSMNLYDFLKV-NHF-------QG----YNLNLVRRFGAQILTSLRFLS-- Prp4_Ddis_PRP4 NHLCIVFEPMSMSLHQLIKKYGKD-------IG----LSLNAVRVYAKQLFLALKHIKN- YakA_Ddis_YAK MHLCIVFELLSVNLFELIKQ-NNF-------RG----LSTNLIKVFLIQILDALIVLA-- 22349_Tthe_YAK NHFCLVFEMLELSLYDYLKN-TKF-------CG----FSFSVIAQWTKSILEGMVIAE-- 10580_Tthe_DyrkP EHLFIVTELLKDNLYEFYKF-NRE-------NETQPYFTLGRLQKITQQILIGLDYIHS- 22423_Tthe_DyrkP EHLFIITELLEENLYEFYKF-NRE-------NEQQRYFTVGRLQKITQQILVALDFIHS- 5306_Tthe_DYRK2 NHVCLVFELLSINLYDLLRN-NKF-------QG----LSLELIRRFAIQLLNAISFLK-- 5356_Tthe_DYRK2 SHVGLL-------------------------------------------------FLT-- 5655_Tthe_DYRK2 KHVI----------------------------------------------LNSINFLR-- 15575_Tthe_PRP4 KHMCLVFECFAMNLRDALKEYGKG-------KG----FSLDVVRSYAYQIFVALTHLKK- DYRK1_Spur_DYRK1 NHLCLVFELLSYNLYDLLRN-TNF-------RG----VSLNLTRKFAQQMCTALLFLATP DYRK2_Spur_DYRK2 NHICITFELLSMNLYELIKK-NKF-------QG----FSLQLVRKFAHSLLQCLEGLH-- DYRK4_Spur_DYRK2 NHLCITFELLGMNLYELIKK-NNF-------QG----FSVALIRRFAFSLLQCLRMLH-- HIPKa_Spur_HIPK NHTCLVFELLEKNLYDFLKQ-SKF-------RP----LPLKHIRPTLQQVLVALLKLK-- HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 QHLCLVFEPLSMNLREVLKRYGKD-------VG----LHIKAVRSYTQQLFLALKLLKR- CG7028_Dmel_PRP4 QHLCMVFEPLAMNLREVLKKYGKN-------VG----LHIKAVRSYTQQLFLALKLLKK- CC1G_13957_Ccin_DYRK2 NHLCIATELLSINLYELIKA-NGF-------VG----FTTALIRRFTTQMLMSLSLMR-- CC1G_04865_Ccin_PRP4 GHLCLVFENLSMNLREVVKRFGKD-------VG----LNIRAVRAYAHQLFLALSLLRK- CC1G_14245_Ccin_YAK SHLCLVFELLSSNLYELIKQ-NQF-------QG----LSTQLVKVFMAQLLDALTVLK-- AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 GHLCFVFELLSYNLYELLRN-TNF-------RG----VSLNLTRKFAQQLCTALLFLSTH AqueK112_Aque_DYRK2 NHLCITFELMGMNLYELIKK-NNF-------QG----FSISLIRRFAYSMLQCLKILY-- AqueK113_Aque_DYRK2 NHVCITFELLSMNLYELIKK-NKF-------QG----FSLALVRKFAHSILQCLDSLY-- AqueK114_Aque_HIPK GHICIVFELLHINLYDYLKQ-SRF-------DP----LPLKYIRPIAQQVLCCLEKLA-- AqueK115_Aque_PRP4 NHLCLVFESMSMNIREVLRKYGKN-------IG----LHIKAVRSYSQQLLLALKLMKR- AqueK116_Aque_PRP4 NHLCLVFESMSMNIREVLRKYGKN-------IG----LHIKAVRSYSQQLLLALKLMKR- DYRK2_b_Smoe_DYRK2 GHLCLSFAVHDISLFDMLKK-NHF-------EG----FNLSLVKCFARQVLVSLQFLH-- DYRK2_a_Smoe_DYRK2 GHLCLSFAVHDISLFDMLKK-NHF-------EG----FNLSLVKCFARQVLVSLQFLH-- DYRKP-2_Smoe_DYRKP EHLFIVCELLRANLYEFHKY-NRD-------SGGEVYFTMPRLQSITRQCLEALEFLHG- DYRKP-1_Smoe_DYRKP EHLFIVCELLRANLYEFHKY-NRD-------SGGEVYFTMPRLQSITRQCLEALEFLHG- PRP4_e_Smoe_PRP4 EHLCLVMESLDLNLRQITNKYGRN-------RG----INLKTICVYAHQLMVALQHLAH- PRP4_d_Smoe_PRP4 EHLCLVMEFLDLNLRQITNKYGRN-------RG----INLKTICVYAHQLMVALQHLAH- PRP4_b_Smoe_PRP4 NHLCLVFESLHMNLREILKKFGRN-------IG----ISLAAVRSYARQLFTALKHLRN- PRP4_a_Smoe_PRP4 NHLCLVFESLHMNLREILKKFGRN-------IG----ISLAAVRSYARQLFTALKHLRN- PRP4_c_Smoe_PRP4 EHLCLVMESLDLNLRQITNKYGRN-------RG----INLKTICVYAHQLMVALQHLAH- YAK_b_Smoe_YAK QHLCIAFELLSHNLYELIKV-NRH-------RG----ISLHLLRIFTKQILDSLGVLR-- YAK_a_Smoe_YAK QHLCIAFELLSHNLYELIKV-NRH-------RG----ISLHLLRIFTKQILDSLGVLR-- YAK_d_Smoe_YAK -------------------------------------------MSIMTQLLEALQVLE-- GK031_Glam_DYRK1 NHYCIVMEALGSNLYHLLKS-TKM-------QG----FPLQTIRVWARKYLTSFKKLQHE GK034_Glam_DYRK2 SHLCIAFELLSINLYELLTK-KDL-------KG----LSLSLVRKFSLQLLIAFAYAR-- GK033_Glam_DYRK2 EHLLLKFTLLGEDLYTHFNR-REK-------KGQPNDYTIPVIRDMARQVLKALDYIHR- GK032_Glam_DYRK2 HRLIIIFELLTSNLFSYYSA-REAALPRTLLNPLATIFTMPRLQHIARQILESLDFLHR- PRP4_Hsap_PRP4 -CNILHADIKPDNILVNE-S------KTILKLCDFGSASHVADN---DITPYLVSRFYRA HIPK4_Hsap_HIPK ELAIIHADLKPENIMLVDQT----RCPFRVKVIDFGSASIFSEVRYV-KEPYIQSRFYRA HIPK3_Hsap_HIPK SLGLIHADLKPENIMLVDPV----RQPYRVKVIDFGSASHVSKTVC---STYLQSRYYRA HIPK2_Hsap_HIPK SLGLIHADLKPENIMLVDPS----RQPYRVKVIDFGSASHVSKAVC---STYLQSRYYRA HIPK1_Hsap_HIPK SLGLIHADLKPENIMLVDPV----RQPYRVKVIDFGSASHVSKAVC---STYLQSRYYRA smi35A_Dmel_DYRK2 KENIIHCDLKPENILLKQRG----SS--SIKVIDFGSSCYVDRK-I---YTYIQSRFYRS mnb_Dmel_DYRK1 ELNIIHCDLKPENILLCNPK----RS--AIKIVDFGSSCQLGQR-I---YHYIQSRFYRS Dyrk3_Dmel_DYRK2 KNDIIHCDMKPENVLLKQQG----RS--GIKVIDFGSSCFENQR-I---YTYIQSRFYRA CG17090_Dmel_HIPK QLGLIHADLKPENIMLVDPV----RQPYRVKVIDFGSASHVSKTVC---NTYLQSRYYRA PRP4_Mmus_PRP4 -CNILHADIKPDNILVNE-S------KTILKLCDFGSASHVADN---DITPYLVSRFYRA HIPK4_Mmus_HIPK ELAIIHADLKPENIMLVDQT----RCPFRVKVIDFGSASIFSEVRYV-KEPYIQSRFYRA HIPK3_Mmus_HIPK SLGLIHADLKPENIMLVDPV----RQPYRVKVIDFGSASHVSKTVC---STYLQSRYYRA HIPK2_Mmus_HIPK SLGLIHADLKPENIMLVDPS----RQPYRVKVIDFGSASHVSKAVC---STYLQSRYYRA HIPK1_Mmus_HIPK SLGLIHADLKPENIMLVDPV----RQPYRVKVIDFGSASHVSKAVC---STYLQSRYYRA DYRK4_Mmus_DYRK2 VEKIIHCDLKPENIVLYQRG----QV--TVKVIDFGSSCYEHQK-V---YTYIQSRFYRS DYRK3_Mmus_DYRK2 KNKIIHCDLKPENILLKHHG----RS--ATKVIDFGSSCFEYQK-L---YTYIQSRFYRA DYRK2_Mmus_DYRK2 KNRIIHCDLKPENILLKQQG----RS--SIKVIDFGSSCYEHQR-V---YTYIQSRFYRA DYRK1B_Mmus_DYRK1 ELSIIHCDLKPENILLCNPK----RS--AIKIVDFGSSCQLGQR-I---YQYIQSRFYRS DYRK1A_Mmus_DYRK1 ELSIIHCDLKPENILLCNPK----RS--AIKIVDFGSSCQLGQR-I---YQYIQSRFYRS mbk-2_Cele_DYRK2 KNRLIHCDLKPENVLLKQQG----RS--GIKVIDFGSSCFDDQR-I---YTYIQSRFYRA mbk-1_Cele_DYRK1 ELSIIHCDLKPENVLLVNAK----RS--QIRVIDFGSSCQTGHR-I---YQYIQSRFYRS hpk-1_Cele_HIPK SLGLIHADLKPENIMLVDPQ----QQPYRVKVIDFGSASHRSKAVT---NTYLQSRYYRA F22D6.5_Cele_PRP4 -LEFVHADIKPDNILVNE-S------KLTLKLCDFGSAGRVNEQ---ELAPYLVSRFYRA C36B7.2_Cele_DYRK2 -HNIVHGDLKPENIMLNLAN------PNDVKLGDFGLSRFAKPY---HDHVQCQSMFYRA C36B7.1_Cele_DYRK2 -NKIIHGDLKPANVLLNEWN------RNNLKLTDFGLSTFVNQG---PFFRDYQTLYYKA DYRK4_Hsap_DYRK2 VEKIIHCDLKPENIVLYQKG----QA--SVKVIDFGSSCYEHQK-V---YTYIQSRFYRS DYRK3_Hsap_DYRK2 KNKIIHCDLKPENILLKHHG----RS--STKVIDFGSSCFEYQK-L---YTYIQSRFYRA DYRK2_Hsap_DYRK2 KNRIIHCDLKPENILLKQQG----RS--GIKVIDFGSSCYEHQR-V---YTYIQSRFYRA DYRK1B_Hsap_DYRK1 ELSIIHCDLKPENILLCNPK----RS--AIKIVDFGSSCQLGQR-I---YQYIQSRFYRS DYRK1A_Hsap_DYRK1 ELSIIHCDLKPENILLCNPK----RS--AIKIVDFGSSCQLGQR-I---YQYIQSRFYRS YAK1_Scer_YAK ESKLIHCDLKPENILLCAPD----K--PELKIIDFGSSCEEART-V---YTYIQSRFYRA Dyrk1_Ddis_DYRK1 EVDVIHCDLKPENILLRNPK----RS--AIKIIDFGSSCHSNER-M---YKYIQSRFYRS Dyrk2_Ddis_DYRK2 KRNIIHADLKPENILLKSPT----KS--GIKLIDFGSSCFENEQ-I---FTYIQSRFYRS Prp4_Ddis_PRP4 -SKILHADIKPDNIVVNE-A------KNTIKIVDFGSAGEIHES---EITPYLVSRFYRA YakA_Ddis_YAK NANIIHCDLKPENILLQNVN----S--PAIKIIDFGSACYEKST-L---YTYIQSRHYRS 22349_Tthe_YAK SKQIIHCDLKPENIMLKKQL----ILNQTLKM---AT-KFSQQ-K--------------- 10580_Tthe_DyrkP -LRLIHCDLKPENILMKSYS------KCQVKIIDFGSSCFIHD----HLSSYVQSRSYRA 22423_Tthe_DyrkP -LRLIHCDLKPENILMKSKP------KGEVKVIDFGSSCFIHD----HLSSYVQSRSYRA 5306_Tthe_DYRK2 ENRIIHCDLKPENVLLKQPN----KS--GIKIADFGSSCFDDQV-M---YTYIQSRYYRS 5356_Tthe_DYRK2 KANIIHCDLKPENILLKQEN----KS--GIKIVDFGSSCFENQR-V---YTYIQSRFYRA 5655_Tthe_DYRK2 KNRIIHCDLKPENILLKQAN----KS--GVKLIDFGSSCFENER-L---YTYIQSRYYRA 15575_Tthe_PRP4 -NNYIHADLKPDNLLISE-D------TKTLKMCDFGTALPIEEN---GIIKYLQSRFYRA DYRK1_Spur_DYRK1 ELNIIHCDLKPENILLCNPK----RS--AIKIIDFGSSCQLGQR-I---YQYIQSRFYRS DYRK2_Spur_DYRK2 RNKIIHCDLKPENILLKQQG----RS--GIKVIDFGSSCYEHQR-I---YTYIQSRFYRA DYRK4_Spur_DYRK2 KERIIHCDLKPENILLRQKG----QS--TIKVIDFGSSCYEHQR-V---YTYIQSRFYRS HIPKa_Spur_HIPK TLGLIHADLKPENIMLVDPV----RQPYRVKVIDFGSASHVSKAVC---STYLQSRYYR- HIPKb_Spur_HIPK ----------------------------------------------------------RA PRP4_Spur_PRP4 -CNILHADIKPDNILVNE-S------KSVLKLCDFGSASHVADN---DITPYLVSRFYRA CG7028_Dmel_PRP4 -TGILHADIKPDNILVNE-N------NLILKLCDFGSASAISDN---EITPYLVSRFYRS CC1G_13957_Ccin_DYRK2 HHRIVHCDLKPENVLLRHPA----KS--AIKVIDFGSSCLEHEK---------------- CC1G_04865_Ccin_PRP4 -ANIMHADIKPDNILVNE-Q------KNLIKLCDLGSASDASEN---EITPYLVSRFYRA CC1G_14245_Ccin_YAK EARLIHCDLKPENILLKSLQ----S--PQIKVIDFGSACHERQT-V---YTYIQSRFYRS AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 DINVIHCDLKPENILLCNPK----RS--AIRIVDFGSSCQVGSR-M---FQYIQSRFYRS AqueK112_Aque_DYRK2 RERIIHCDLKPENILLRLRG----QS--SIKVIDFGSSCYEHQR-V---YTYIQSRFYRS AqueK113_Aque_DYRK2 RNRIIHCDLKPENILLKQPG----RS--GIKVIDFGSSCYEYQR-V---YTYIQSRFYRA AqueK114_Aque_HIPK SLGLVHADLKPENIMLVDPQ----RYPFKVKVIDFGSAMSRDKTSP---SCYLQSRYYRA AqueK115_Aque_PRP4 -CTILHADIKPDNILVNE-S------KLMLKLCDFGSASFIQDN---EITPYLVSRFYRA AqueK116_Aque_PRP4 -CTILHADIKPDNILVNE-S------KLMLKLCDFGSASFIQDN---EITPYLVSRFYRA DYRK2_b_Smoe_DYRK2 RARIIHGDLKPENILLQQPA----SP--KIKLIDFGSSCFEHER-I---YTYIQSRFYRA DYRK2_a_Smoe_DYRK2 RARIIHGDLKPENILLQQPA----SP--KIKLIDFGSSCFEHER-I---YTYIQSRFYRA DYRKP-2_Smoe_DYRKP -LGLIHCDLKPENILVKSYS------RCEVKVIDLGSSCFQSD----HLCSYVQSRSYRA DYRKP-1_Smoe_DYRKP -LGLIHCDLKPENILVKSYS------RCEVKVIDLGSSCFQSD----HLCSYVQSRSYRA PRP4_e_Smoe_PRP4 -CGILHCDIKPDNIMVTK-S------RRSIKLCDFGVAMFARDQTPSAETPYLVSPSYRA PRP4_d_Smoe_PRP4 -CGILHCDIKPDNIMVTK-S------RRSIKLCDFGVAMFARDQTPSAETPYLVSPSYRA PRP4_b_Smoe_PRP4 -CGVLHCDIKPDNMLVND-S------KNLLKLCDFGSAMFAGEN---EITPYLVSRFYRA PRP4_a_Smoe_PRP4 -CGVLHCDIKPDNMLVND-S------KNLLKLCDFGSAMFAGEN---EITPYLVSRFYRA PRP4_c_Smoe_PRP4 -CGIFHCDIKPDNIMVTK-S------RRSIKLCDFGVAMFARDQTPSAETPYLVSPSYRA YAK_b_Smoe_YAK NAGVIHCDLKPENILLSTSL----KS-GEIKLIDFGSACLEHRT-V---YKYIQF----- YAK_a_Smoe_YAK NAGVIHCDLKPENILLSTSL----KS-GEIKLIDFGSACLEHRT-V---YKYIQSRYYRS YAK_d_Smoe_YAK RHGVVHRDLKPENIVLSS------QG--ELRLIDFGS----------------------- GK031_Glam_DYRK1 SIRIIHTDCKPENTLIPFNN----TCVEDIRIVDFGSAVRYPEG---QMFLYIQSRYYRA GK034_Glam_DYRK2 KLRIIHADVKPENILLREPD----KS--SIKVIDWGSGAMVSET-I---YSYIQSRFYRA GK033_Glam_DYRK2 -LGITHLDLKPENLLHGDKNFIGGVNEPSVTLVDFGSSSFIFD----KMHSYIQSRSYRA GK032_Glam_DYRK2 -LNILHLDLKHENLLLVNED----DDSFDIRLVDIGSSAFLYD----ECSTYVQSRSYRC PRP4_Hsap_PRP4 PEIIIGK-SYDYGIDMWSVGCTLYELYTGKILFPGKTNNH--------MLKLAMDLKGK- HIPK4_Hsap_HIPK PEILLGL-PFCEKVDVWSLGCVMAELHLGWPLYPGNNEYD--------QVRYICETQGL- HIPK3_Hsap_HIPK PEIILGL-PFCEAIDMWSLGCVIAELFLGWPLYPGALEYD--------QIRYISQTQGL- HIPK2_Hsap_HIPK PEIILGL-PFCEAIDMWSLGCVIAELFLGWPLYPGASEYD--------QIRYISQTQGL- HIPK1_Hsap_HIPK PEIILGL-PFCEAIDMWSLGCVIAELFLGWPLYPGASEYD--------QIRYISQTQGL- smi35A_Dmel_DYRK2 PEVILGL-QYGTAIDMWSLGCILAELYTGFPLFPGENEVE--------QLACIMEVLGL- mnb_Dmel_DYRK1 PEVLLGI-QYDLAIDMWSLGCILVEMHTGEPLFSGCNEVD--------QMNKIVEVLGM- Dyrk3_Dmel_DYRK2 PEVILGG-KYGRAIDMWSLGCILAELLSGHALFPGENESD--------QLACIIEVLGM- CG17090_Dmel_HIPK PEIILGL-PFCEAIDMWSLGCVVAELFLGWPLYPGSSEFD--------QIRYISQTQGL- PRP4_Mmus_PRP4 PEIIIGK-SYDYGIDMWSVGCTLYELYTGKILFPGKTNNH--------MLKLAMDLKGK- HIPK4_Mmus_HIPK PEILLGL-PFCEKVDVWSLGCVMAELHLGWPLYPGNNEYD--------QVRYICETQGL- HIPK3_Mmus_HIPK PEIILGL-PFCEAIDMWSLGCVIAELFLGWPLYPGALEYD--------QIRYISQTQGL- HIPK2_Mmus_HIPK PEIILGL-PFCEAIDMWSLGCVIAELFLGWPLYPGASEYD--------QIRYISQTQGL- HIPK1_Mmus_HIPK PEIILGL-PFCEAIDMWSLGCVIAELFLGWPLYPGASEYD--------QIRYISQTQGL- DYRK4_Mmus_DYRK2 PEVILGH-PYNMAIDMWSLGCIMAELYTGYPLFPGENEVE--------QLACIMEVLGL- DYRK3_Mmus_DYRK2 PEIILGC-RYSTPIDIWSFGCILAELLTGQPLFPGEDEGD--------QLACMIELLGM- DYRK2_Mmus_DYRK2 PEVILGA-RYGMPIDMWSLGCILAELLTGYPLLPGEDEGD--------QLACMIELLGM- DYRK1B_Mmus_DYRK1 PEVLLGT-PYDLAIDMWSLGCILVEMHTGEPLFSGSNEVD--------QMSRIVEVLGI- DYRK1A_Mmus_DYRK1 PEVLLGM-PYDLAIDMWSLGCILVEMHTGEPLFSGANEVD--------QMNKIVEVLGI- mbk-2_Cele_DYRK2 PEVILGT-KYGMPIDMWSLGCILAELLTGYPLLPGEDEND--------QLALIIELLGM- mbk-1_Cele_DYRK1 PEVLLGI-AYDTKIDMWSLGCILVEMHTGEPLFAGSSEVD--------QMMKIVEVLGM- hpk-1_Cele_HIPK PEIILGL-PFNESIDMWSLGCVIAELFLGWPLYPGSSEYD--------QIRFIIQTQGL- F22D6.5_Cele_PRP4 PEIMLGV-RHDYAIDLWSVAVTLYEVYTGKIMFPGRTNNH--------MLKLFTDVKGK- C36B7.2_Cele_DYRK2 PEAFVRG-RYNGATDMWSFGCTVAEMVSGKIFLAGDNCDD--------QFYLMQEVINI- C36B7.1_Cele_DYRK2 PEVFCQG-KVSVEIDIWSLGCVAAEIVRGTPLFVGDNYFD--------QFALIQEFFGK- DYRK4_Hsap_DYRK2 PEVILGH-PYDVAIDMWSLGCITAELYTGYPLFPGENEVE--------QLACIMEVLGL- DYRK3_Hsap_DYRK2 PEIILGS-RYSTPIDIWSFGCILAELLTGQPLFPGEDEGD--------QLACMMELLGM- DYRK2_Hsap_DYRK2 PEVILGA-RYGMPIDMWSLGCILAELLTGYPLLPGEDEGD--------QLACMIELLGM- DYRK1B_Hsap_DYRK1 PEVLLGT-PYDLAIDMWSLGCILVEMHTGEPLFSGSNEVD--------QMNRIVEVLGI- DYRK1A_Hsap_DYRK1 PEVLLGM-PYDLAIDMWSLGCILVEMHTGEPLFSGANEVD--------QMNKIVEVLGI- YAK1_Scer_YAK PEIILGI-PYSTSIDMWSLGCIVAELFLGIPIFPGASEYN--------QLTRIIDTLGY- Dyrk1_Ddis_DYRK1 PEILLEL-EYSFSIDMWSLGCILVEMHVGEPLFSGQNEQD--------QLTKIIEVLDL- Dyrk2_Ddis_DYRK2 PEVILGT-KYDKSIDIWSLGCILVEIFTGVPLFPGSDEPE--------QLACIMEVLGA- Prp4_Ddis_PRP4 PEIILGH-KYDYSIDVWSVGCCLAEFFTGKFLFPGKTNND--------MIRLFMEYRGA- YakA_Ddis_YAK PEVLVGT-VYCASIDMWSLGCISAELFLGLPLFPGNSEYN--------QISRIVEMRGI- 22349_Tthe_YAK -----WM-IYTTAIDMWSLGCILVELFLGLPIFPGNSEYD--------QIKRIIDILGK- 10580_Tthe_DyrkP PEVILGC-KYDYKIDMWSLGCILAELWTGNVLFQNDTVQG--------LLARVIGIIGP- 22423_Tthe_DyrkP PEVIIGC-KYDYRIDIWSLGCILAELWTGNVLFQNDNIQG--------LLARVIGIIGP- 5306_Tthe_DYRK2 PEVILGI-PYGTEIDMWSFGCIIAELFLGYPIFPGEDENE--------QMGYIMELLGA- 5356_Tthe_DYRK2 PEIILGL-PYGKAIDMWSFGCIMAELYIGYPLFPGENEAE--------QFQMFMEILGI- 5655_Tthe_DYRK2 PEVILGL-PYDTSIDMWSFGCIMAELFIGYPIFPGEDEQE--------QIGYIWEIIGA- 15575_Tthe_PRP4 PEVLIGY-PPYNQIDVWSVGVTLYEIYTQKILFDGSTNNE--------MLKLIMDSRGK- DYRK1_Spur_DYRK1 PEVLLGI-SYDMAIDMWSLGCILVEMHTGEPLFSGSNELD--------QMNKIIEVLGM- DYRK2_Spur_DYRK2 PEVILGG-KYGMPIDMWSLGCILAELLTGYPLLPGEDEGD--------QLACMIEVMGM- DYRK4_Spur_DYRK2 PEVILGL-PYGLPIDMWSFGCILAELYTGYPLFPGENEVE--------QLACIMEIFGL- HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK PEIILGL-PFCEAIDMWSLGCVVAELFLGWPLYPGASEYD--------QIRYISQTQGL- PRP4_Spur_PRP4 PEIIIGM-NYDAAIDMWSTGCTIFELAAGKIMFPGKTNNH--------MLKLFMDLKGK- CG7028_Dmel_PRP4 PEIILGI-PYDYGIDTWSAGCTIYELYTGKILFSGKSNNQ--------MLKFFMDVKGK- CC1G_13957_Ccin_DYRK2 -----------------------TELYTGFPIFPGENEQE--------QLSCIMEVLGV- CC1G_04865_Ccin_PRP4 PEIILGV-PYDPALDVWSIGCTLYELYTGKILFPGRSNNQ--------MLRLMMELKGR- CC1G_14245_Ccin_YAK PEVLLGM-PYTAAIDMWSLGCIAVELFLGLPLFPGTSEYN--------QLTRIIEMLGM- AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 PEVLLGI-PYDLAIDMWSLGCILVEMHTGEPLFSGKDEID--------QMSKIVEVLGI- AqueK112_Aque_DYRK2 PEVILGL-PYSMAIDMWSLGCILAELYTGYPLFPGENEVE--------QLACIIEIFGL- AqueK113_Aque_DYRK2 PEVILGG-KYGMSIDMWSFGCILAELLTGYPLFPGEDEGD--------QLACMMEVLGL- AqueK114_Aque_HIPK PEVILGV-NFNEGIDMWSLGCVLAELYLGWPLFPGASEFD--------QITYICQTLGP- AqueK115_Aque_PRP4 PE---------------------------------------------------------- AqueK116_Aque_PRP4 PEIIIGC-KYDYGIDMWSVGATLYELYTGQILFPGKSNNE--------MLKLNMELKGK- DYRK2_b_Smoe_DYRK2 PEVILGL-PYDMMIDVWSFACILAELFTGYPLFPGEDEVE--------QLAYMMEVLGT- DYRK2_a_Smoe_DYRK2 PEVILGL-PYDMMIDVWSFACILAELFTGYPLFPGEDEVE--------QLAYMMEVLGT- DYRKP-2_Smoe_DYRKP PEVILGL-PYDQKIDIWSLGCILAELCSGNVLFQNDSLAT--------LLARVVGIIGP- DYRKP-1_Smoe_DYRKP PEVILGL-PYDQKIDIWSLGCILAELCSGNVLFQNDSLAT--------LLARVVGIIGP- PRP4_e_Smoe_PRP4 PEIILGVAPYSHAIDMWSAGCCLYELYTGKFLFPVATNNG--------LLKQQMELKGA- PRP4_d_Smoe_PRP4 PEIILGVAPYSHPIDMWSAGCCLYELYTGKFLFPVATNNG--------LLKQQMELKGA- PRP4_b_Smoe_PRP4 PEIILGL-PYDHALDMWSVGCCLYELYTGKVLFPGSTNND--------MLRLHMELKGP- PRP4_a_Smoe_PRP4 PEIILGL-PYDHALDMWSVGCCLYELYTGKVLFPGSTNND--------MLRLHMELKGP- PRP4_c_Smoe_PRP4 PEIILGVAPYSHQIDMWSAGCCLYELYTGKFLFPVATNNG--------LLKQQMELKGA- YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK PEVVLGH-PYTTAIDMWSLGCVAAELFLGLPLFSGESEYD--------LLRRMIDTLGCQ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 PEVLLLQ-PYDYQIDIWSIAAILFEMHTGKVLFPAKSSEI--------LCYMMVDILGY- GK034_Glam_DYRK2 PEVILGL-PYGQEIDIWSIGCVLCELYTGLPIFPGDDERD--------QLGKICELLGM- GK033_Glam_DYRK2 PEVILAT-PYDSRADIWSFGCVVCELLTGRVLFPNYSVAT--------ILSRICSLIGP- GK032_Glam_DYRK2 PEVILGL-PYDGRADVWSLGPILTELITGKVMFPIPQKADEDHKPYASMLAKLIGIIGP- PRP4_Hsap_PRP4 MPNKMIRKGVFKDQ------HFDQN-------------LNFM--------Y--------- HIPK4_Hsap_HIPK PKPHLLHAACKAHH------FFKRN-------------PHPDA-------A--------- HIPK3_Hsap_HIPK PGEQLLNVGTKSTR------FFCKE-------------TDMSH-------S--------- HIPK2_Hsap_HIPK PAEYLLSAGTKTTR------FFNRD-------------TDSPY-------P--------- HIPK1_Hsap_HIPK PAEYLLSAGTKTTR------FFNRD-------------PNLGY-------P--------- smi35A_Dmel_DYRK2 PPKVLISVARRRRL------FFDSR-------------DAPR--------C--------- mnb_Dmel_DYRK1 PPKYLY------------------------------------------------------ Dyrk3_Dmel_DYRK2 PNKNILAS---------------------------------------------------- CG17090_Dmel_HIPK PTEHMLNS---------------------------------------------------- PRP4_Mmus_PRP4 MPNKMIRKGVFKDQ------HFDQN-------------LNFM--------Y--------- HIPK4_Mmus_HIPK PKPHLLHAARKAHH------FFKRN-------------PHPDA-------T--------- HIPK3_Mmus_HIPK PGEQLLNVGTKSTR------FFCRE-------------TDMSH-------S--------- HIPK2_Mmus_HIPK PAEYLLSAGTKTTR------FFNRD-------------TDSPY-------P--------- HIPK1_Mmus_HIPK PAEYLLSAGTKTTR------FFNRD-------------PNLGY-------P--------- DYRK4_Mmus_DYRK2 PPAHFTQTASRRQV------FFDSK-------------GLPK--------N--------- DYRK3_Mmus_DYRK2 PPQKLLEQSKRAKY------FINSK-------------GLPR--------Y--------- DYRK2_Mmus_DYRK2 PSQKLLDASKRAKN------FVSSK-------------GYPR--------Y--------- DYRK1B_Mmus_DYRK1 PPAPMLEQAPKARK------YFERL-------------PGG-GW------T--------- DYRK1A_Mmus_DYRK1 PPAHILDQAPKARK------FFEKL-------------PDG-TW------S--------- mbk-2_Cele_DYRK2 PPPKSLETAKRART------FITSK-------------GYPR--------Y--------- mbk-1_Cele_DYRK1 PPKEMLDIGPKTHK------YFDKT-------------EDG-IY------Y--------- hpk-1_Cele_HIPK PPTSMLESASKLHR------FFKEV-------------KSESPNHTNVGGS--------- F22D6.5_Cele_PRP4 YPNKLVRKSQFKDT------HFDVN-------------CNLL--------Y--------- C36B7.2_Cele_DYRK2 PPPVFFDTFYTNYY------FFSTLK------------EAPK--------H--------- C36B7.1_Cele_DYRK2 PSRKLFNTWGGIHQ------FYTEY-------------FFPR--------H--------- DYRK4_Hsap_DYRK2 PPAGFIQTASRRQT------FFDSK-------------GFPK--------N--------- DYRK3_Hsap_DYRK2 PPPKLLEQSKRAKY------FINSK-------------GIPR--------Y--------- DYRK2_Hsap_DYRK2 PSQKLLDASKRAKN------FVSSK-------------GYPR--------Y--------- DYRK1B_Hsap_DYRK1 PPAAMLDQAPKARK------YFERL-------------PGG-GW------T--------- DYRK1A_Hsap_DYRK1 PPAHILDQAPKARK------FFEKL-------------PDG-TW------N--------- YAK1_Scer_YAK PPSWMIRE---------------------------------------------------- Dyrk1_Ddis_DYRK1 PPSHMIDSSPKAKK------FFTKD-------------PINSTY------Q--------- Dyrk2_Ddis_DYRK2 PPKSVIDNSTRKDI------FFEDD-------------GTPK--------P--------- Prp4_Ddis_PRP4 FSKKMLKKSEFVSN------HFNEN-------------LVFM--------K--------- YakA_Ddis_YAK FPSDLLDKGKSSTR------YFHRH-------------LGSNSD------DNNNNNNNNN 22349_Tthe_YAK PTNEVIEQGRFKNK------FFKCL-------------DGE--Y------I--------- 10580_Tthe_DyrkP IPEWMFQEGRLVNN------FFTNK-------------RLLY--------Q--------- 22423_Tthe_DyrkP FPEWMMKEGRLVQN------FFTRE-------------KLLY--------M--------- 5306_Tthe_DYRK2 PDSEFLKKCSRKKY------FFDQN-------------DQPL--------Q--------- 5356_Tthe_DYRK2 PEEEFVENCPRRNV------FFENN-------------KTPK--------V--------- 5655_Tthe_DYRK2 PSKDFLQNCTRRKY------FFNED-------------YTPK--------L--------- 15575_Tthe_PRP4 FNKKMLQNGKYVEE------YFDQN-------------YNFK--------Y--------- DYRK1_Spur_DYRK1 PPNHIIEQAPKAHK------YFIKT-------------EK--TW------V--------- DYRK2_Spur_DYRK2 PSQNLIDTSKRSKN------FINSK-------------GQPR--------Y--------- DYRK4_Spur_DYRK2 PPP--------------------------------------------------------- HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK PAEHLLSAATKTTR------FFKRD-------------IESNF-------P--------- PRP4_Spur_PRP4 MPHKIIRKGILRDK------HFDPN-------------CNFK--------Y--------- CG7028_Dmel_PRP4 IPNRIIVT---------------------------------------------------- CC1G_13957_Ccin_DYRK2 PDKEYINRSSRKKL------FFDTN-------------GAPR--------P--------- CC1G_04865_Ccin_PRP4 FNTKIIKKAKFGET------YFDEL-------------GAFE--------S--------- CC1G_14245_Ccin_YAK PPLSMLNSGKQTK----------------------------------------------- AqueK110_Aque_DYRK1 -----------RDR------FFERE-------------SGG-TW------V--------- AqueK111_Aque_DYRK1 PPPHVLERSARRDR------FFERE-------------SGG-TW------V--------- AqueK112_Aque_DYRK2 PDPALLAEAQRKKL------FFDSR-------------GNPR--------C--------- AqueK113_Aque_DYRK2 PSQKMIESTKRGRT------FFSSK-------------GHPR--------Y--------- AqueK114_Aque_HIPK LPHHLMRNITKATR------FFNCD-------------PVTS------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 MSHKMVRKGMFREN------HFDSS-------------FNFL--------Y--------- DYRK2_b_Smoe_DYRK2 PPLSLISQAKRKKM------FFDSD-------------NKPR--------I--------- DYRK2_a_Smoe_DYRK2 PPLSLISQAKRKKM------FFDSD-------------NKPR--------I--------- DYRKP-2_Smoe_DYRKP LDPEMVARGRESYK------FLTKN-------------SKLY--------E--------- DYRKP-1_Smoe_DYRKP LDPEMVARGRESYK------FLTKN-------------GKLY--------E--------- PRP4_e_Smoe_PRP4 FPKAMLKKGAFTGM------HFNEN-------------FEFR--------Q--------- PRP4_d_Smoe_PRP4 FPKAMLKKGAFTGM------HFNEN-------------FEFR--------Q--------- PRP4_b_Smoe_PRP4 FPKKMLRKAMFTAQ------HFDQD-------------LNFH--------A--------- PRP4_a_Smoe_PRP4 FPKKMLRKAMFTAQ------HFDQD-------------LNFH--------A--------- PRP4_c_Smoe_PRP4 FPKAMLKKGAFTGM------HFNEN-------------FEFR--------Q--------- YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK PPDQLLRDSANTSK------YFKTV-------------SAAPPS------S--------G YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 PPKEMIMDEEQKQISNSLKRYFKMRKQEDAELFHLNENAFPH--------Q--------- GK034_Glam_DYRK2 PPNDMIFKSPRKND------FFVNI-------------GTGM--------G--------- GK033_Glam_DYRK2 IPRDMIMSGRMGQR------VLTFG-------------LVPY--------E--------- GK032_Glam_DYRK2 IPRDMILAGRESHK------LFTKD-------------LFLF--------E--------- PRP4_Hsap_PRP4 ----I-EVD---KV----------------TE---RE-K-----------------V--- HIPK4_Hsap_HIPK ---NPWQLK---SS----------------ADY---L----------------------- HIPK3_Hsap_HIPK ----GWRLK---TL----------------EEH---E----------------------- HIPK2_Hsap_HIPK ----LWRLK---TP----------------DDH---E----------------------- HIPK1_Hsap_HIPK ----LWRLK---TP----------------EEH---E----------------------- smi35A_Dmel_DYRK2 ----I-TNT--------------------------------------------------- mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ----I-EVD---KV----------------TE---RE-K-----------------V--- HIPK4_Mmus_HIPK ---NPWQLK---SS----------------ADY---L----------------------- HIPK3_Mmus_HIPK ----GWRLK---TL----------------EEH---E----------------------- HIPK2_Mmus_HIPK ----LWRLK---TP----------------DDH---E----------------------- HIPK1_Mmus_HIPK ----LWRLK---TP----------------EEH---E----------------------- DYRK4_Mmus_DYRK2 ----I-NNN--------------------------------------------------- DYRK3_Mmus_DYRK2 ----C-SVS---TQ----------------TDG---R----------------------- DYRK2_Mmus_DYRK2 ----C-TVT---TL----------------SDG---S----------------------- DYRK1B_Mmus_DYRK1 ----L-RRT---K------------------EL---R----------------------- DYRK1A_Mmus_DYRK1 ----L-KKT---K------------------DG---K----------------------- mbk-2_Cele_DYRK2 ----C-TAT---SM----------------PDG---S----------------------- mbk-1_Cele_DYRK1 ----C-KKT---R------------------DG---Y----------------------- hpk-1_Cele_HIPK ----YYRLK---TV----------------EEY---E----------------------- F22D6.5_Cele_PRP4 ----Q-EVD---KV----------------TE---RN-K-----------------I--- C36B7.2_Cele_DYRK2 ----I--V---ITD----------------HG-P----------------------IV-S C36B7.1_Cele_DYRK2 ----C--FEWLNPF----------------NG-D-R--T-----------------MEIE DYRK4_Hsap_DYRK2 ----I-TNN--------------------------------------------------- DYRK3_Hsap_DYRK2 ----C-SVT---TQ----------------ADG---R----------------------- DYRK2_Hsap_DYRK2 ----C-TVT---TL----------------SDG---S----------------------- DYRK1B_Hsap_DYRK1 ----L-RRT---K------------------EL---R----------------------- DYRK1A_Hsap_DYRK1 ----L-KKT---K------------------DG---K----------------------- YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ----L-KKN---E------------------KL---K----------------------- Dyrk2_Ddis_DYRK2 ----V-KNS---TT---------------------------------------------- Prp4_Ddis_PRP4 ----Q-EID---NI----------------EK---TV-R----------------KV--P YakA_Ddis_YAK GKPYYYTLK---SE----------------EDY---Q----------------------- 22349_Tthe_YAK ----F-KTK---------------------QEF---E----------------------- 10580_Tthe_DyrkP ----D-VFEEGEPS----------------QN-I-ND-T-----------------SDMP 22423_Tthe_DyrkP ----E-VFEEADQS----------------QA-I-GD-Q-----------------QDGQ 5306_Tthe_DYRK2 ----I-PNS--------------------------------------------------- 5356_Tthe_DYRK2 ----V-KNS--------------------------------------------------- 5655_Tthe_DYRK2 ----I-PNS--------------------------------------------------- 15575_Tthe_PRP4 ----T-YVD---KQ----------------TN---QK-Y-----------------T--- DYRK1_Spur_DYRK1 ----L-KRS---R------------------DG---K----------------------- DYRK2_Spur_DYRK2 ----C-TVT---TL----------------PDG---T----------------------- DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ----LWRLK---NP----------------EEH---E----------------------- PRP4_Spur_PRP4 ----V-EVD---KV----------------TE---RE-K-----------------V--- CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ----V-VNS--------------------------------------------------- CC1G_04865_Ccin_PRP4 ----V-ERD---RL----------------TG---SD-I-----------------T--- CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ----L-KRQ---R------------------DG---R----------------------- AqueK111_Aque_DYRK1 ----L-KRQ---R------------------DG---R----------------------- AqueK112_Aque_DYRK2 ----V-TNS--------------------------------------------------- AqueK113_Aque_DYRK2 ----T-TVN---IN----------------PDG---T----------------------- AqueK114_Aque_HIPK ----TWSLK---SI----------------SQY---T----------------------- AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ----H-TVD---KV----------------TQ---KE-K-----------------V--- DYRK2_b_Smoe_DYRK2 ----V-PNS--------------------------------------------------- DYRK2_a_Smoe_DYRK2 ----V-PNS--------------------------------------------------- DYRKP-2_Smoe_DYRKP ----R-N-Q--------------------------------------------------- DYRKP-1_Smoe_DYRKP ----R-N-Q--------------------------------------------------- PRP4_e_Smoe_PRP4 -------LD---PV----------------TK---LE-T-----------------L--- PRP4_d_Smoe_PRP4 -------LD---PV----------------TK---LE-T-----------------L--- PRP4_b_Smoe_PRP4 ----I-EED---PV----------------TK---K-------------------TI--N PRP4_a_Smoe_PRP4 ----I-EED---PV----------------TK---KV-QFCIFPVYSFLHLLSFQTI--N PRP4_c_Smoe_PRP4 -------LD---PV----------------TK---LE-T-----------------L--- YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK GMAV-YQFL---TV----------------SEV---K-A--------------------- YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ----V-VPDSYLLN----------------KS-V-IE-M-----------------AEAQ GK034_Glam_DYRK2 ----V-AGV---SEGGNPIFSGNLQQLSSVNEYLQATGR-----------------GAGG GK033_Glam_DYRK2 ----H-D-E--------------------------KN----------------------- GK032_Glam_DYRK2 ----T-R-E---AI----------------LG-N-RD-K-----------------AEGL PRP4_Hsap_PRP4 ----------TVMSTI-NPTKDLLADLI---G------C--Q--RLPEDQRKKVHQLKDL HIPK4_Hsap_HIPK AET-KVRP--LERRKYMLK---SLDQIETVN-GGSVASRLTFPDREALAEHADLKSMVEL HIPK3_Hsap_HIPK AET-GMKS--KEARKYIFN---SLDDVAHVN-T---VMD--LEGSDLLAEKADRREFVSL HIPK2_Hsap_HIPK AET-GIKS--KEARKYIFN---CLDDMAQVN-M---TTD--LEGSDMLVEKADRREFIDL HIPK1_Hsap_HIPK LET-GIKS--KEARKYIFN---CLDDMAQVN-M---STD--LEGTDMLAEKADRREYIDL smi35A_Dmel_DYRK2 -----------KGRKR-SPGSKSLAHIL----------------------HCQDRYFIDF mnb_Dmel_DYRK1 ------------------------------------------------------LKFKDL Dyrk3_Dmel_DYRK2 -----------------------------------------------------DPLFLNF CG17090_Dmel_HIPK ------------------------------------------------------REFIDL PRP4_Mmus_PRP4 ----------TVMSTI-NPTKDLLADLI---G------C--Q--RLPEDQRKKVHQLKDL HIPK4_Mmus_HIPK AET-KVRP--LERRKYMLK---SLDQIETVN-GGGAVSRLSFPDREALAEHADLKSMVEL HIPK3_Mmus_HIPK AET-GMKS--KEARKYIFN---SLDDIVHVN-T---VMD--LEGGDLLAEKADRREFVNL HIPK2_Mmus_HIPK AET-GIKS--KEARKYIFN---CLDDMAQVN-M---TTD--LEGSDMLVEKADRREFIDL HIPK1_Mmus_HIPK LET-GIKS--KEARKYIFN---CLDDMAQVN-M---STD--LEGTDMLAEKADRREYIDL DYRK4_Mmus_DYRK2 -----------RGGKR-YPDSKDLTMVV----------------------KTYDSSFLDF DYRK3_Mmus_DYRK2 VVLLGGRS--RRGKKRGPPGSKDWATAL---------------------KGCGDYLFIEF DYRK2_Mmus_DYRK2 VVLNGGRS--RRGKLRGPPESREWGNAL---------------------KGCDDPLFLDF DYRK1B_Mmus_DYRK1 -----------K-DYQ-GPGTRRLQEVLGVQ-TGGP-GG--RRAGEPGHSPADYLRFQDL DYRK1A_Mmus_DYRK1 -----------R-EYK-PPGTRKLHNILGVE-TGGP-GG--RRAGESGHTVADYLKFKDL mbk-2_Cele_DYRK2 VVLAGARS--KRGKMRGPPASRSWSTAL---------------------KNMGDELFVDF mbk-1_Cele_DYRK1 -----------RHTYK-APGARKLHEILGVT-SGGP-GG--RRLGEPGHSVEDYSKFKDL hpk-1_Cele_HIPK ASSSTAKS--KETRKYIFN---VIDDISRVC-Y---GFE--SDPVEHLCDRIDRQEFVDV F22D6.5_Cele_PRP4 ----------TVLANL-KPTRDLESELI---A------G--Q--RLSRDQMDQIQAFRTL C36B7.2_Cele_DYRK2 FI--YTKA--AD-HRK-IPGATPIG---------------------SFFTKTEQKPFNNF C36B7.1_Cele_DYRK2 PH--YKLA--HP-SRK-PPLTSSLV---------------------SKLPGGNQKFLARF DYRK4_Hsap_DYRK2 -----------RGKKR-YPDSKDLTMVL----------------------KTYDTSFLDF DYRK3_Hsap_DYRK2 VVLVGGRS--RRGKKRGPPGSKDWGTAL---------------------KGCDDYLFIEF DYRK2_Hsap_DYRK2 VVLNGGRS--RRGKLRGPPESREWGNAL---------------------KGCDDPLFLDF DYRK1B_Hsap_DYRK1 -----------K-DYQ-GPGTRRLQEVLGVQ-TGGP-GG--RRAGEPGHSPADYLRFQDL DYRK1A_Hsap_DYRK1 -----------R-EYK-PPGTRKLHNILGVE-TGGP-GG--RRAGESGHTVADYLKFKDL YAK1_Scer_YAK -------------------------------------------------------CLIHF Dyrk1_Ddis_DYRK1 -----------T-NVE--FCKKKLSEIIGVE-TGGP-QS--RRKNEPGHALVDYLKFLDL Dyrk2_Ddis_DYRK2 ------------GELY-TIGTKSFKDSI----------------------RSGDEDFDNF Prp4_Ddis_PRP4 ----------HDITK---PTKDILQFLL---P------K---NVSIPDQDMKKLIQLKDL YakA_Ddis_YAK RDS-KTTL--LPSKKYFN--YKTLPEIIQNYGF---KKS--MSPQDIEKEKQHRIVFTDF 22349_Tthe_YAK ISE-GIQL--KESKTYFQV--ACLNDLKNYM-YN--SQF--RRNEDDTKNNRQFDLFLDL 10580_Tthe_DyrkP GR--RQKS--GKIQIL-VPKKSNLR---------------------ARL-KTDDLMFLDF 22423_Tthe_DyrkP RQ--KIKT--GKIQIL-VPKHSNLK---------------------ARL-RTEDHLFIDF 5306_Tthe_DYRK2 -----------RGKIR-MPNSKNWKSVI----------------------GCTDDNFIDF 5356_Tthe_DYRK2 -----------RGKIR-TPATKHINYYL----------------------RCPDENFIDF 5655_Tthe_DYRK2 -----------KGKIR-VPNSKILKAVL----------------------QTESEDFTDF 15575_Tthe_PRP4 ----------TIITYGDIPKKDIYRLLQ---E------N---KDGINLENQKKLSQFKDF DYRK1_Spur_DYRK1 -------------KYK-SPRTRKLQDILGVE-LGGP-GG--RRAGEPGHTVSDPHKFKDP DYRK2_Spur_DYRK2 TVLNGGRS--RRGKVRGPPGSKDLVKAL---------------------KGCDDPLFLDF DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK TET-SVKS--KEARKYIFN---CLDDIAGVN-L---PTD--LEGSDYLAEKADRREFVEL PRP4_Spur_PRP4 ----------TVMTVI-NPTKDLTTELL---G------Y--Q--RLPEDQQRKVLQLKDV CG7028_Dmel_PRP4 -------------------------------------------------------QLKDL CC1G_13957_Ccin_DYRK2 -----------KGRRR-RPGSKTLAQVL----------------------RCNDEEFIDF CC1G_04865_Ccin_PRP4 ----------RKIHIQ-KPTRDLRARLM---P------S--SSVKLNDEETKMLANFIDL CC1G_14245_Ccin_YAK --------------------------------------------------LNNRAAFIDF AqueK110_Aque_DYRK1 -----------KDHHR-RPGSRSLYEVLGGD-KGGP-GG--LRKGDSGHTPNDYYKFRDL AqueK111_Aque_DYRK1 -----------KDHHR-RPGSRSLYEILGGD-KGGP-GG--LRKGDSGHTPNDYYKFRDL AqueK112_Aque_DYRK2 -----------KGKKR-RPGSKDLSSAI----------------------KTSDLLFLDF AqueK113_Aque_DYRK2 ASYTGGRS--RRGKFRGPPGTKDMSRAL---------------------KGCDDPQFLDF AqueK114_Aque_HIPK QET-GIQS--KESRKYIFR---SLLDMNHLPPL---AAG--IDNREAILTSVDRMEFISL AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ----------VVMSSF-SPQRDLLADLV---G------S--Q--SPSEAHLRKIHHFKDF DYRK2_b_Smoe_DYRK2 -----------SGTRH-FPSTKDLRMVV----------------------GCSDKSFVNF DYRK2_a_Smoe_DYRK2 -----------SGTRH-FPSTKDLRMVV----------------------GCSDKSFVNF DYRKP-2_Smoe_DYRKP ------ET--SRMEYL-IPKKTTLA---------------------HRL-PMGDQGFLEF DYRKP-1_Smoe_DYRKP ------ET--SRMEYL-IPKKTTLA---------------------HRL-PMGDQGFLEF PRP4_e_Smoe_PRP4 ----------RSMASF-NVKTSCISDLT-------------------GEDGALMARFKNL PRP4_d_Smoe_PRP4 ----------RSMASF-NVKTSCISDLT-------------------GEDGALMARFKNL PRP4_b_Smoe_PRP4 ----------RMITNV--KPKDI-STLI---S------S----SGGSDEDAKNLLNFKLL PRP4_a_Smoe_PRP4 ----------RMITNV--KPKDI-STLI---S------S----SGGSDEDAKNLLNFKLL PRP4_c_Smoe_PRP4 ----------RSMASF-NVKTSCLSDLT-------------------GEDGALMSRFKNL YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK RES-KEP---LVGKSYFR--HTKLEDIISKYPY---KSS--LSAEEQEAERQRRLSFLDF YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 KE--RIFGRPLRELIR-NPVMTQYE---------------------GH-TSADYEEFEEF GK034_Glam_DYRK2 SEVPGIRL----RTTH-KVNSKTLSGVL----------------------NA-PDDFISF GK033_Glam_DYRK2 ----------RQHFYF-TPQQGLLEYWL---F------G---ERC-ANL-TDEEVLFSDF GK032_Glam_DYRK2 RHA-EIKG--EDYVYV-LPKKTTIKAML----------G---WDS--HP-EYCDDLFLDF PRP4_Hsap_PRP4 LDQILMLDPAKRISINQAL----Q HIPK4_Hsap_HIPK IKRMLTWESHERISPSAALRHPFV HIPK3_Hsap_HIPK LKKMLLIDADLRITPAETLNHPFV HIPK2_Hsap_HIPK LKKMLTIDADKRITPIETLNHPFV HIPK1_Hsap_HIPK LKKMLTIDADKRITPLKTLNHQFV smi35A_Dmel_DYRK2 LQRCLEWDPAERMTPDEAAHHEFL mnb_Dmel_DYRK1 ILRMLDFDPKTRVTPYYALQHNFF Dyrk3_Dmel_DYRK2 IRGCLEWDADKRLTPSEALKHPWL CG17090_Dmel_HIPK LKRMLTIDQERRLTPAEALNHSFT PRP4_Mmus_PRP4 LDQILMLDPAKRISINQAL----Q HIPK4_Mmus_HIPK IKRMLTWESHERISPSAALRHPFV HIPK3_Mmus_HIPK LKKMLLIDADLRITPIETLNHPFV HIPK2_Mmus_HIPK LKKMLTIDADKRVTPIETLNHPFV HIPK1_Mmus_HIPK LKKMLTIDADKRITPLKTLNHQFV DYRK4_Mmus_DYRK2 LRRCLVWEPSLRMTPEQALKHAWI DYRK3_Mmus_DYRK2 LKRCLQWDPSARLTPAQALRHPWI DYRK2_Mmus_DYRK2 LKQCLEWDPAVRMTPGQALRHPWL DYRK1B_Mmus_DYRK1 VLRMLEYEPAARISPLGALQHGFF DYRK1A_Mmus_DYRK1 ILRMLDYDPKTRIQPYYALQHSFF mbk-2_Cele_DYRK2 LKRCLDWDPETRMTPAQALKHKWL mbk-1_Cele_DYRK1 IKRMLQFDPKQRISPYYVVRHPFL hpk-1_Cele_HIPK LKKMLVLNPDFRITPAEGLESKFV F22D6.5_Cele_PRP4 LDGMLILDPSKRTTCNEALKHPFF C36B7.2_Cele_DYRK2 ILKVFKWMPASRITAKQALDHPFF C36B7.1_Cele_DYRK2 LMRCFEWDPTERIKSSFILNHPFF DYRK4_Hsap_DYRK2 LRRCLVWEPSLRMTPDQALKHAWI DYRK3_Hsap_DYRK2 LKRCLHWDPSARLTPAQALRHPWI DYRK2_Hsap_DYRK2 LKQCLEWDPAVRMTPGQALRHPWL DYRK1B_Hsap_DYRK1 VLRMLEYEPAARISPLGALQHGFF DYRK1A_Hsap_DYRK1 ILRMLDYDPKTRIQPYYALQHSFF YAK1_Scer_YAK LGGVLNLNPLERWTPQQAMLHPFI Dyrk1_Ddis_DYRK1 IEKMLIYDPQKRITPLEALQHSFF Dyrk2_Ddis_DYRK2 ILDCLKWEPSQRITAEQGLKHDWI Prp4_Ddis_PRP4 IEKCTILDPEKRITPFEA-----L YakA_Ddis_YAK INGLLQLDPNERWSPMQAKEHPFI 22349_Tthe_YAK ATQLLELNPRKRVKASIAMQHPFL 10580_Tthe_DyrkP VKSLLQIDRTRRPSAKEALQHPWL 22423_Tthe_DyrkP VRQCLQIDFTRRPTAKEALSHPWF 5306_Tthe_DYRK2 IKKCLVWEPSQRLTPRDALLHPWI 5356_Tthe_DYRK2 VSKCFTWKNHERMSPAEALVHDWI 5655_Tthe_DYRK2 LTKCFVWEPQKRLKPSDALMHPWI 15575_Tthe_PRP4 LDKCLQLDPKNRITPEEALEHPFL DYRK1_Spur_DYRK1 ILRMLEYDPASRIKPYYALQHSFF DYRK2_Spur_DYRK2 LKRCLEWDPSSRMTPSQALRHSWL DYRK4_Spur_DYRK2 -----------------------H HIPKa_Spur_HIPK -----------------------C HIPKb_Spur_HIPK LKKMLTIDPDKRITPLEALNHPFV PRP4_Spur_PRP4 LDRCLMLDPSKRISINEVLRHSFI CG7028_Dmel_PRP4 LENMFALDPAKRISLNQALVHPFI CC1G_13957_Ccin_DYRK2 IAKCLVWDPERRMKPQAAMRHPFV CC1G_04865_Ccin_PRP4 LDKCLMLDPARRITPREALSHPFI CC1G_14245_Ccin_YAK CKGLLDLNPVTRWTPQQARLHPFI AqueK110_Aque_DYRK1 VLQMLDYDPETRIKPLAALKHPFF AqueK111_Aque_DYRK1 VLQMLDYDPETRIKPLAALKHPFF AqueK112_Aque_DYRK2 IRRCLVWSASERMKPEEALQHAWI AqueK113_Aque_DYRK2 LRHCLEWDPAIRMTPPQALRHPWL AqueK114_Aque_HIPK LSRMLSLDPTQRIRPLSALQSPFI AqueK115_Aque_PRP4 -----------------------I AqueK116_Aque_PRP4 LDKIFILDPTKRLSINQALQHPFI DYRK2_b_Smoe_DYRK2 LSCCLKWDKEQRMTPQQLLKHEWI DYRK2_a_Smoe_DYRK2 LSCCLKWDKEQRMTPQQLLKHEWI DYRKP-2_Smoe_DYRKP VAFLLQINPKNRPSAAEALKHPWL DYRKP-1_Smoe_DYRKP VAFLLQINPKNRPSAAEALKHPWL PRP4_e_Smoe_PRP4 LERMLTLDPSKRITPDEALKHPFL PRP4_d_Smoe_PRP4 LERMLTLDPSKRITPDEALKHPFL PRP4_b_Smoe_PRP4 LEKIFILDPEKRLTVSQALNHPFI PRP4_a_Smoe_PRP4 LEKIFILDPEKRLTVSQALNHPFI PRP4_c_Smoe_PRP4 LERMLTLDPSKRITPDEALKHPFL YAK_b_Smoe_YAK ------------------CNPSCY YAK_a_Smoe_YAK LRGLVRFDPKSRWTPHQAAQHPFV YAK_d_Smoe_YAK -----------------------A GK031_Glam_DYRK1 LSKILVYDPKRRWTIDEALNSRFL GK034_Glam_DYRK2 ISLFLQWDPQRRCTPEVAMSHPWI GK033_Glam_DYRK2 CRQALIVDPIKRPTAAMLLEHPFI GK032_Glam_DYRK2 IETIMRIDPRKRPTAAEALEHPWL