CLUSTAL W (1.83) multiple sequence alignment Egfr_Dmel LRKGGVLGMGAFGRVYKGVWVPE-GENVKIPVAIKELLKSTGAESSEEFLREAYIMASVE ErbB4_Mmus LKRVKVLGSGAFGTVYKGIWVPE-GETVKIPVAIKILNETTGPKANVEFMDEALIMASMD ErbB3_Mmus LRKLKVLGSGVFGTVHKGIWIPE-GESIKIPVCIKVIEDKSGRQSFQAVTDHMLAVGSLD ErbB2_Mmus LRKLKVLGSGAFGTVYKGIWIPD-GENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVG EGFR_Mmus FKKIKVLGSGAFGTVYKGLWIPE-GEKVKIPVAIKELREATSPKANKEILDEAYVMASVD let-23_Cele TKLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTD--QSQTDEMLEEATNMFRLR ErbB4_Hsap LKRVKVLGSGAFGTVYKGIWVPE-GETVKIPVAIKILNETTGPKANVEFMDEALIMASMD ErbB3_Hsap LRKLKVLGSGVFGTVHKGVWIPE-GESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLD ErbB2_Hsap LRKVKVLGSGAFGTVYKGIWIPD-GENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVG EGFR_Hsap FKKIKVLGSGAFGTVYKGLWIPE-GEKVKIPVAIKELREATSPKANKEILDEAYVMASVD EGFR_Spur LKLGPVLGSGAFGTVYKGLWIPD-GEKIRIPVAIKALREV-SPHAAEELLEEAKVMASVD AqueK263_Aque ------------------------------------------------------------ AqueK264_Aque ------------------------------------------------------------ AqueK265_Aque LEFGKELGAGAFGTVYEGYWKPA-NDENEYHVAIKVLKNT-SASASKELLQEGVVMATMD AqueK266_Aque LEFKKELGSGTFGTVYEGYWKPD-NDEAEYHVAIKILKST-SADASKEL----------- Egfr_Dmel HVNLLKLLAVCMSS-QMMLITQLMPLGCLLDYV---------------------RNNRDK ErbB4_Mmus HPHLVRLLGVCLSP-TIQLVTQLMPHGCLLDYV---------------------HEHKDN ErbB3_Mmus HAHIVRLLGLCPGS-SLQLVTQYLPLGSLLDHV---------------------RQHRET ErbB2_Mmus SPYVSRLLGICLTS-TVQLVTQLMPYGCLLDHV---------------------REHRGR EGFR_Mmus NPHVCRLLGICLTS-TVQLITQLMPYGCLLDYV---------------------REHKDN let-23_Cele HDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFL---------------------KLHKEN ErbB4_Hsap HPHLVRLLGVCLSP-TIQLVTQLMPHGCLLEYV---------------------HEHKDN ErbB3_Hsap HAHIVRLLGLCPGS-SLQLVTQYLPLGSLLDHV---------------------RQHRGA ErbB2_Hsap SPYVSRLLGICLTS-TVQLVTQLMPYGCLLDHV---------------------RENRGR EGFR_Hsap NPHVCRLLGICLTS-TVQLITQLMPFGCLLDYV---------------------REHKDN EGFR_Spur HPCLLRLLCVCIAQ-NMTLITQLMPLGAILDYV---------------------RQHKEQ AqueK263_Aque ------------------------------------------------------------ AqueK264_Aque ---------------------------------------------------------RNS AqueK265_Aque HENVVRLYCVCMSK-QLMLVSQFVPCGALIDYI---------------------KKQQDR AqueK266_Aque ----LQVXGLCISR-QIMLVSQLVPLGSLIAYLKNHKNKISAQTVINFSLQIAKXXHRNS Egfr_Dmel IGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNE ErbB4_Mmus IGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKE ErbB3_Mmus LGPQLLLNWGVQIAKGMYYLEEHSMVHRDLALRNVMLKSPSQVQVADFGVADLLPPDDKQ ErbB2_Mmus LGSQDLLNWCVQIAKGMSYLEEVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETE EGFR_Mmus IGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKE let-23_Cele LGAREQVLYCYQIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADS ErbB4_Hsap IGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKE ErbB3_Hsap LGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQ ErbB2_Hsap LGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETE EGFR_Hsap IGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKE EGFR_Spur IGSHHLLNWSFQIAKGMVYLEEKHLIHRDLAARNVLVQSPAQVKITDFGLAKFLEVDSNE AqueK263_Aque ------------------------LVHRDLAARNALVQSHLKVLITDFGLTRFIEPDESH AqueK264_Aque ISAQTVINFSLQIAKGMAYLESKSLVHRDLAARNVLVQSHLKVLITDFGLTRFIEPDESH AqueK265_Aque LNAHTILLFSSQIANGMAYLETKHLVHRDLAARNVLVQTPVKVKITDFGLTRIIEANQSH AqueK266_Aque ISAQTVINFSLQIAKGMAYLESKSLVHRDLAARNILVQSHLKVLITDFGLTRFIKPDESH ::**:** ** :::. * ::***:: :: : Egfr_Dmel YKAAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIE ErbB4_Mmus YNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLE ErbB3_Mmus LLHSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEIPDLLE ErbB2_Mmus YHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLE EGFR_Mmus YHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASDISSILE let-23_Cele ITIKSGKVAIKWLAIEIFSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLK ErbB4_Hsap YNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLE ErbB3_Hsap LLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLE ErbB2_Hsap YHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLE EGFR_Hsap YHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILE EGFR_Spur YKAQ----------------------------GVTLWELMTFGGKPYEGVKAREVPELLE AqueK263_Aque YEASGSKLPVRWLPPESIRQRIFTHKTDIWSFGVTVWEILTFGESPFKGKSVFELLKLLE AqueK264_Aque YEAPGSKLPVRWLPPESIQQRIFTHKTDVWSFGVTVWEILTFGESPFKGKSVFELLKLLE AqueK265_Aque YEATTSKMPVRWLPPESIRNRVFTHKTDVWSFGVTVWEILTFGARPYQGKKPYEILKMLE AqueK266_Aque YEASGSKLPVRWLPPESIQQRIFTHKTDVWSFGVTVWEILTFGESPFKGKSVFELLKLLE *** **::*** *. . .: .::: Egfr_Dmel VGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTT---V-F ErbB4_Mmus KGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAA---EFS ErbB3_Mmus KGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELAN---E-F ErbB2_Mmus KGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVS---EFS EGFR_Mmus KGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIL---EFS let-23_Cele DGNRLSQPPNCSQDLYQELLRCWMADPKSRPGFEILYE---RFK ErbB4_Hsap KGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAA---EFS ErbB3_Hsap KGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELAN---E-F ErbB2_Hsap KGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVS---EFS EGFR_Hsap KGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELII---EFS EGFR_Spur RGERLPQPPICTIDIYMLMVKCWLIDEDSRPTFKQMQE---ELE AqueK263_Aque KGDRLKQPKTCTLVFYKSLQNCWELEPEKRPSFEDLVY---Q-F AqueK264_Aque KGDRLKQPKTCTLEFYKTLQNCWELEPERRPSFEDLVY---Q-F AqueK265_Aque GGHRLDQPVTCTIDLYAVLLECWLLEPDSRPDFVDLGRRFHEFM AqueK266_Aque KGDRLKQPKTCTLEFYKTLQNCWELEPEKRPSFEDLVY---Q-F * :* ** *: .* : ** : ** * :