CLUSTAL W (1.83) multiple sequence alignment FGFR4_Hsap LVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKL FGFR3_Hsap LTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKM FGFR2_Hsap LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM FGFR1_Hsap LVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKM htl_Dmel LVLGATLGEGAFGRVVMAEV---------NNAIVAVKMVKEGHTDDDIASLVREMEVMKI btl_Dmel LSLGSILGEGAFGRVVMAEAEGLPRSPQLAETIVAVKMVKEEHTDTDMASLVREMEVMKM FGFR4_Mmus LVLGKPLGEGCFGQVVRAEAFGMDPSRPDQTSTVAVKMLKDNASDKDLADLVSEMEVMKL FGFR3_Mmus LTLGKPLGEGCFGQVVMAEAIGIDKDRTAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKM FGFR2_Mmus LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM FGFR1_Mmus LVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKM egl-15_Cele LSLVHMLGEGAFGEVWKATY----KETENNEIAVAVKKLKMSAHEKELIDLVSEMETFKV FGFR_Spur LTVGKTIGEGAFGKVVIGEAVGIVC--QEKTSTVAVKMLKANAMDREFSDLISELAMMKM * : :***.**.* . **** :* : :: .*: *: :*: FGFR4_Hsap IGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDG---------- FGFR3_Hsap IGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDT---------- FGFR2_Hsap IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDI---------- FGFR1_Hsap IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNP---------- htl_Dmel IGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSS--------- btl_Dmel IGKHINIINLLGCCSQGGPLWVIVEYAPHGNLKDFLKQNRPGAPQRRSDSDGYL------ FGFR4_Mmus IGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDG---------- FGFR3_Mmus IGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGMDYSFDA---------- FGFR2_Mmus IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDI---------- FGFR1_Mmus IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNP---------- egl-15_Cele IGEHENVLRLIGCCTGAGPLYVVVELCKHGNLRDFLRAHRPKEEKAKKSSQELTDYLEPR FGFR_Spur IGKNPNIINLLGCCTQEGPPYVIVEFAHHGNLRDFLRSRRPPE-EYEKSI---------- **.: *::.*:* *: ** :*:** . :***:::* .** . . FGFR4_Hsap --------PRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKI FGFR3_Hsap --------CKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKI FGFR2_Hsap --------NRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKI FGFR1_Hsap --------SHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKI htl_Dmel -----QPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKI btl_Dmel -----DDKPLISTQHLGEKELTKFAFQIARGMEYLASRRCIHRDLAARNVLVSDGYVMKI FGFR4_Mmus --------PRSSEGPLSFPALVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDDVMKI FGFR3_Mmus --------CRLPEEQLTCKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKI FGFR2_Mmus --------NRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKI FGFR1_Mmus --------SHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKI egl-15_Cele KASDKDDIELI--PNLTQRHLVQFAWQVAQGMNFLASKKIIHRDLAARNVLVGDGHVLKI FGFR_Spur --------LLTTSQTLTNKDLMSMAYQVARGMDFLASKKCIHRDLAARNVLVTEDFEMKI : * . : *:*:**::* *:: ************ :. :** FGFR4_Hsap ADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGS FGFR3_Hsap ADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGS FGFR2_Hsap ADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGS FGFR1_Hsap ADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGS htl_Dmel ADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQ btl_Dmel ADFGLARDIQDTEYYRKNTNGRLPIKWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQ FGFR4_Mmus ADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGS FGFR3_Mmus ADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGS FGFR2_Mmus ADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGS FGFR1_Mmus ADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGS egl-15_Cele SDFGLSRDVHCNDYYRKRGNGRLPIKWMALEALDSNVYTVESDVWSYGVLLWEIMTLGGT FGFR_Spur CDFGLARDIHYIDFYRKTTDGRLPVKWMAPEALFDRMFTTQSDVWSFGILLWEIMTLGGT .****:*.:: ::*:* :****:**** *:* .. : :*****:*:*:***:* * FGFR4_Hsap PYPGI-PVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEAL FGFR3_Hsap PYPGI-PVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDL FGFR2_Hsap PYPGI-PVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL FGFR1_Hsap PYPGV-PVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL htl_Dmel PYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYM btl_Dmel PYPHILSAEELYSYLITGQRMEKPAKCSLNIYVVMRQCWHFESCARPTFAELVESF FGFR4_Mmus PYPGI-PVEELFSLLREGHRMERPPNCPSELYGLMRECWHAAPSQRPTFKQLVEAL FGFR3_Mmus PYPGI-PVEELFKLLKEGHRMDKPASCTHDLYMIMRECWHAVPSQRPTFKQLVEDL FGFR2_Mmus PYPGI-PVEELFKLLKEGHRMDKPTNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL FGFR1_Mmus PYPGV-PVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL egl-15_Cele PYPTI-AMPELYANLKEGYRMEPPHLCPQEVYHLMCSCWREKLEERPSFKTIVDYL FGFR_Spur PYPSV-PVEQMFDYLRSGKRLEKPQNTSLEIYHILCECWRTSPGQRPTFCELVEDL *** : . ::: * * *:: * . ::* :: .**: **.* :*: :