CLUSTAL W (1.83) multiple sequence alignment RHOK_Hsap_GRK FLDFRVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILMKVH--- GPRK7_Hsap_GRK FTEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKKRLKKKGGEKMALLEKEILEKVS--- GPRK6_Hsap_GRK FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVN--- GPRK5_Hsap_GRK FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVN--- GPRK4_Hsap_GRK FRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQ--- Gprk1_Dmel_BARK FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGEMLALNERNMLQAVSTGI Gprk2_Dmel_GRK FRMYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGESMVLIEKQILQKIN--- GPRK6_Mmus_GRK FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVN--- GPRK5_Mmus_GRK FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVN--- GPRK4_Mmus_GRK FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKRILEKLH--- BARK2_Mmus_BARK FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRVKMKQGETLALNERIMLSLVSTG- BARK1_Mmus_BARK FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG- F19C6.1_Cele_GRK FRLYRVLGKGGFGEVCACQVRASGKMYALKKLEKKRVKKRHAETLSLNEKQILQRIN--- BARK1_Hsap_BARK FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG- BARK2_Hsap_BARK FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG- RHOK_Mmus_GRK FLDFRVLGKGGFGEVSACQMKATGKMYACKKLNKKRLKKRKGYQGAIVEKRILTKVH--- W02B3.2_Cele_BARK FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGQ BARK_Spur_BARK FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKSGETLALNERIMLSLVSET- GPRK_Spur_GRK ------------------------------------------------------------ AqueK007_Aque_BARK FNVHRIIGRGGFGEVFGCRKDDSGKMFAMKLLDKKRIKVKRGELLALNERNMLAKVN--- AqueK008_Aque_GRK FRQYRVLGKGGFGLVFACQSKFTGKMYALKKLEKKRVKKRKGEKLALNEKEVLEKVD--- RHOK_Hsap_GRK -SRFIVSLAYAFETKADLCLVMTIMNGGDIRYHIYNVNEENPGFPEPRALFYTAQIICGL GPRK7_Hsap_GRK -SPFIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVG--TRGLDMSRVIFYSAQIACGM GPRK6_Hsap_GRK -SRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMG--QAGFPEARAVFYAAEICCGL GPRK5_Hsap_GRK -SQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMG--NPGFEEERALFYAAEILCGL GPRK4_Hsap_GRK -SRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLG--NPGFDEQRAVFYAAELCCGL Gprk1_Dmel_BARK DCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHG----IFSEDEMKFYAAEVILGL Gprk2_Dmel_GRK -SPFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGG-EPGFELERARFYAAEVACGL GPRK6_Mmus_GRK -SRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMG--QAGFPEARAVFYAAEICCGL GPRK5_Mmus_GRK -SQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMG--NPGFEEERALFYAAEILCGL GPRK4_Mmus_GRK -SRFVVSLAYTYETKDALCLVLTIMNGGDLKYHIYNLG--DPGFEEPRAVFYAAELCCGL BARK2_Mmus_BARK DCPFIVCMTYAFHTPDKLCFILDLMNGGDMHYHLSQHG----VFSEKEMRFYASEIILGL BARK1_Mmus_BARK DCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG----VFSEADMRFYAAEIILGL F19C6.1_Cele_GRK -SPFVVSLAYAYETKDALCLVLTLMNGGDLKFHLYNLM--PGGFDEKRVQFYAAEITLGL BARK1_Hsap_BARK DCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG----VFSEADMRFYAAEIILGL BARK2_Hsap_BARK DCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHG----VFSEKEMRFYATEIILGL RHOK_Mmus_GRK -SRFIVSLAYAFETKTDLCLVMTIMNGGDVRYHIYNVDEDNPGFSEPRAIYYTAQIISGL W02B3.2_Cele_BARK DCPFIVCMTYAFQSPDKLCFILDLMNGGDLHYHLSQHG----VFTEQEMIFYASEVILGL BARK_Spur_BARK DCPFIVCMTYAFQTPDKLCFILDLMNGGDLHYHLSQHG----VFSEEEVGFYAAEIILGL GPRK_Spur_GRK --------------KEALCLVLTIMNGGDLKFHIHNMG--SPGFEEERARFYAAEILCGL AqueK007_Aque_BARK -SPFVVNLYYAFQTPEKLCFILDLMNGGDLHYHLTQHG----VFNEAEVRFYAAELILAL AqueK008_Aque_GRK -SRFVVTLAYAYQSKDSLCMVLTLMNGGDLRFHIYSIG--SPGLEPERVVFYAAEIACGL *.::: :*****:::*: : :*:::: .: RHOK_Hsap_GRK EHLHQRRIVYRDLKPENVLLDNDGNVRISDLGLAVELLDGQSKTKGYAGTPGFMAPELLQ GPRK7_Hsap_GRK LHLHELGIVYRDMKPENVLLDDLGNCRLSDLGLAVEMKGGK-PITQRAGTNGYMAPEILM GPRK6_Hsap_GRK EDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQ-TIKGRVGTVGYMAPEVVK GPRK5_Hsap_GRK EDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGD-LIRGRVGTVGYMAPEVLN GPRK4_Hsap_GRK EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQ-RVRGRVGTVGYMAPEVVN Gprk1_Dmel_BARK EHMHKRCIVYRDLKPANILLDENGHIRISDLGLACDFSKKK--PHASVGTHGYMAPEVLS Gprk2_Dmel_GRK QHLHKQGIVYRDCKPENILLDDHGHVRISDLGLAVEIPEGE-MVRGRVGTVGYMAPEVID GPRK6_Mmus_GRK EDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQ-TIKGRVGTVGYMAPEVVR GPRK5_Mmus_GRK EDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGD-LIRGRVGTVGYMAPEVLN GPRK4_Mmus_GRK EDLQRKRIVYRDLKPENILLDDHGHIRISDLGLAMEVPEGE-MVRGRVGTVGYMAPEIIN BARK2_Mmus_BARK EHMHTCFVVYRDLKPANILLDEYGHVRISDLGLACDFSKKK--PHASVGTHGYMAPEVLQ BARK1_Mmus_BARK EHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKR--PHASVGTHGYMAPEVLQ F19C6.1_Cele_GRK QHLHSERILYRDLKPENILLDDFGHVRISDLGLAVEIKDNE-PIKGRVGTVGYMAPEIVK BARK1_Hsap_BARK EHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKK--PHASVGTHGYMAPEVLQ BARK2_Hsap_BARK EHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKK--PHASVGTHGYMAPEVLQ RHOK_Mmus_GRK EHLHQRRIVYRDLKPENVLLDNDGNIRISDLGLAVELKEGQNKTKGYAGTPGFMAPELLR W02B3.2_Cele_BARK EHMHNRFVVYRDLKPANILLDENGHVRVSDLGLACDYSKKK--PHASVGTHGYMAPEVLA BARK_Spur_BARK EHMHVRNVVYRDLKPANILLDENGHVRISDLGLACDFSSKK--PHASVGTHGYMAPEVLS GPRK_Spur_GRK EDLHRLRIVYRDMKPENILLDDHGHVRISDLGLAVEIPEND-TIRGRVGTVGYMAPEVVK AqueK007_Aque_BARK EHIHSQLIVYRDLKPSNVLLDEAGHIRLSDLGLACEFSDRK--PSSCVGTHGYMAPEVIQ AqueK008_Aque_GRK HHLHTARIAYRDMKPDNILLDDAGHIRISDLGLAVHIPEGQ-SVRGRVGTPGYMAPEVID .:: *** ** *:***: *: *:****** . .** *:****:: RHOK_Hsap_GRK -------------------------------------GEEYDFSVDYFALGVTLYEMIAA GPRK7_Hsap_GRK E------------------------------------KVSYSYPVDWFAMGCSIYEMVAG GPRK6_Hsap_GRK -------------------------------------NERYTFSPDWWALGCLLYEMIAG GPRK5_Hsap_GRK -------------------------------------NQRYGLSPDYWGLGCLIYEMIEG GPRK4_Hsap_GRK -------------------------------------NEKYTFSPDWWGLGCLIYEMIQG Gprk1_Dmel_BARK K------------------------------------GTSYDSCADWFSFGCMLYKLLKG Gprk2_Dmel_GRK -------------------------------------NEKYAFSPDWFSFGCLLYEMIEG GPRK6_Mmus_GRK -------------------------------------NERYTFSPDWWALGCLLYEMIAG GPRK5_Mmus_GRK -------------------------------------NQRYGLSPDYWGLGCLIYEMIEG GPRK4_Mmus_GRK -------------------------------------HEKYTFSPDWWGLGCLIYEMIAG BARK2_Mmus_BARK K------------------------------------GTCYDSSADWFSLGCMLFKLLRG BARK1_Mmus_BARK K------------------------------------GVAYDSSADWFSLGCMLFKLLRG F19C6.1_Cele_GRK -------------------------------------NERYSYGVDWWGVGCLIYEMIEG BARK1_Hsap_BARK K------------------------------------GVAYDSSADWFSLGCMLFKLLRG BARK2_Hsap_BARK K------------------------------------GTAYDSSADWFSLGCMLFKLLRG RHOK_Mmus_GRK -------------------------------------GEEYDFSVDYFALGVTLYEMIAA W02B3.2_Cele_BARK K------------------------------------GVAYDSSADWFSLGCMLYKLLKG BARK_Spur_BARK KGTAYDSSADWFSLGCMLFKLLHGGTHGYMAPEVLSKGTAYDSSADWFSLGCMLFKLLHG GPRK_Spur_GRK -------------------------------------NERYTFSPDYWGLGCLIYEMIEG AqueK007_Aque_BARK K------------------------------------GVHYDKSADWFSLGCVLYKLLRG AqueK008_Aque_GRK -------------------------------------GHRYTFAPDWWGMGCLIYEMICG * *::..* ::::: . RHOK_Hsap_GRK RGPFRARGEKVENKELKHRIISEPVKYP-DKFSQASKDFCEALLEKDPEKRLGFRDE--- GPRK7_Hsap_GRK RTPFKDYKEKVSKEDLKQRTLQDEVKFQHDNFTEEAKDICRLFLAKKPEQRLGSREK--- GPRK6_Hsap_GRK QSPFQQRKKKIKREEVERLVKEVPEEYS-ERFSPQARSLCSQLLCKDPAERLGCRGG--- GPRK5_Hsap_GRK QSPFRGRKEKVKREEVDRRVLETEEVYS-HKFSEEAKSICKMLLTKDAKQRLGCQEE--- GPRK4_Hsap_GRK HSPFKKYKEKVKWEEVDQRIKNDTEEYS-EKFSEDAKSICRMLLTKNPSKRLGCRGE--- Gprk1_Dmel_BARK HSPFRQHKTKDK-LEIDKMTLTMNVEL-PESFSLELKNLLEMLLQRDVSKRLGCMGN--- Gprk2_Dmel_GRK QAPFRMRKEKVKREEVDRRVKEDPEKYS-SKFNDEAKSMCQQLLAKSIKQRLGCRNGR-- GPRK6_Mmus_GRK QSPFQQRKKKIKREEVERLVKEVAEEYT-DRFSSQARSLCSQLLSKDPAERLGCRGG--- GPRK5_Mmus_GRK QSPFRGRKEKVKREEVDRRVLETEEVYS-SKFSEEAKSICNMLLTKDSKQRLGCQEE--- GPRK4_Mmus_GRK HSPFRKYKEKVNREELERRVKNETEEYS-ERFSEDAKSICSMLLIKDPSKRLGCQRD--- BARK2_Mmus_BARK HSPFRQHKTKDK-HEIDRMTLTVNVQL-PDAFSPELRSLLEGLLQRDVSQRLGCGGG--- BARK1_Mmus_BARK HSPFRQHKTKDK-HEIDRMTLTMAVEL-PDSFSPELRSLLEGLLQRDVNRRLGCLGR--- F19C6.1_Cele_GRK KAPFRQRKEKVKREEVERRVREDQEKYS-EKFSEAARTLCRGLLHKEPGFRLGCRRVGRP BARK1_Hsap_BARK HSPFRQHKTKDK-HEIDRMTLTMAVEL-PDSFSPELRSLLEGLLQRDVNRRLGCLGR--- BARK2_Hsap_BARK HSPFRQHKTKDK-HEIDRMTLTVNVEL-PDTFSPELKSLLEGLLQRDVSKRLGCHGG--- RHOK_Mmus_GRK RGPFRARGEKVENKELKQRIISEPVKYP-EKFSQASKDFCEQLLEKDPEKRLGFRDG--- W02B3.2_Cele_BARK HSPFRQHKSKDK-NEIDKMTLTQDIELPNEGLSKDCRDLLEGLLKRDVPDRLGCRGK--- BARK_Spur_BARK HSPFRQHKTKDK-HEIDRMTLTMDVEF-PDKMSDEMRALLAGLLQREVASRLGCEGR--- GPRK_Spur_GRK RAPFRARKEKVKREEVDRRVKEDDEKYS-QKFSTEAQDICKKLLQKDPALRMGFEN---- AqueK007_Aque_BARK HSPFRSQ---NK-DEVDQITLTKEVTM-PSSFSPGVSQLLTGLLEKDPTKRLGCLDT--- AqueK008_Aque_GRK RTPFRKHKERVSREDIERRIKDDRVCLDNSAFTEDSRSICDQFLDKVHATRLGCCGE--- : **: . ::.: :. : :* : *:* RHOK_Hsap_GRK --TCDKLRAHPLF GPRK7_Hsap_GRK ---SDDPRKHHFF GPRK6_Hsap_GRK --SAREVKEHPLF GPRK5_Hsap_GRK --GAAEVKRHPFF GPRK4_Hsap_GRK --GAAGVKQHPVF Gprk1_Dmel_BARK --GADEVKMHNFF Gprk2_Dmel_GRK -MGGQDVMAHPFF GPRK6_Mmus_GRK --GAREVKEHPLF GPRK5_Mmus_GRK --GAAEVKRHPFF GPRK4_Mmus_GRK --GVSAVKQHPIF BARK2_Mmus_BARK --GARELKEHIFF BARK1_Mmus_BARK --GAQEVKESPFF F19C6.1_Cele_GRK EDGAEEIRAHPFF BARK1_Hsap_BARK --GAQEVKESPFF BARK2_Hsap_BARK --GSQEVKEHSFF RHOK_Mmus_GRK --TCDALRANVLF W02B3.2_Cele_BARK --GPTEVKEHPFF BARK_Spur_BARK --GATEVREHPFF GPRK_Spur_GRK -GTAQTVKDHSFF AqueK007_Aque_BARK --GVDAIKELPFF AqueK008_Aque_GRK --MFEDVKAHPFF .*