CLUSTAL W (1.83) multiple sequence alignment GSK3B_Hsap YTDTKVIGNGSFGVVYQAK-------------LC---DSG----ELVAIKKVLQDKRFKN GSK3A_Hsap YTDIKVIGNGSFGVVYQAR-------------LA---ETR----ELVAIKKVLQDKRFKN Pk34A_Dmel IEVKDLIGSGSFGRVYQAH-------------VN---ESE----EIVAVKQTLYNPKLSQ sgg_Dmel YTDTKVIGNGSFGVVFQAK-------------LC---DTG----ELVAIKKVLQDRRFKN gskt_Dmel YTDAKVVGNGSFGVVFQAK-------------MV---PSN----EMVAIKKVLQDRRFKN GSK3B_Mmus YTDTKVIGNGSFGVVYQAK-------------LC---DSG----ELVAIKKVLQDKRFKN GSK3A_Mmus YTDIKVIGNGSFGVVYQAR-------------LA---ETR----ELVAIKKVLQDKRFKN R03D7.5_Cele ISAHKLCGSGRFSNVYCGQ-------------MI---SP-IE--KEVAVKNVWSDTETRH F21F3.2_Cele IEEVHLHSCGVFSNVYKGI-------------LR---EP-YE--KKIAIKKSWPEKGERN C44H4.6_Cele FTNLQLIGTGSFGAVYKAV-------------LR---END----EPIAIKKIKVDDRFKS C36B1.10_Cele LQNMNLFASGAFSNVYRGI-------------ART--ESNHQ--MEIVIKKTWPRHKGCP RIM11_Scer FPTTEVVGHGSFGVVFATV-------------IQ---ETN----EKVAIKKVLQDKRFKN MRK1_Scer YPTTEVVGHGSFGVVVTTV-------------II---ETN----QKVAIKKVLQDRRYKN MCK1_Scer VKEYRKIGRGAFGTVVQAY-------------LT---QDKKNWLGPFAIKKVPAHTEYKS Y106G6D.4_Cele MANLRLHARGVFSNVYRGT-------------IL---SPGTE--QEIAIKKTWPKTPYRN Y106G6E.1_Cele LHHMNLFATGAFSNVYRGV-------------AQT--ESNQE--IDIVIKKTWPRHKGCP Y18D10A.5_Cele YYDQKVIGNGSFGVVFLAK-------------LS---TTN----EMVAIKKVLQDKRFKN YOL128C_Scer VREGKRIGHGSFGTVTQSI-------------LS---SNSIEWLGPYAIKRVVKSPKVQS GlkA_Ddis YEIIKQVGQGTFGKVYEAK-------------NQ---D-N----KRVAIKKVEKSNHFIS GSK-3_Ddis YITEGVIGNGSFGVVTQAI-------------VA---DTK----EVVAIKKVLQDQRYKN 19912_Tthe IDENNKIGQGNFGVVFKAE-------------FK---DTK----EEVAVKRVLQDKNFKN 19923_Tthe -------------------------------------ETG----ETVAIKKVFQDRRYKN 19924_Tthe GDEDKVVGSGTFGVVYQAT-------------TK---ETG----EVVAIKKVFQDKRYKN 2636_Tthe YEIKRVIGSGSFGYVFEAY-------------DN---NNQ----RTVALKRIQKVGKKLS 5825_Tthe ITLDKIIGNGTFGVVYLAK-------------MN---DTQ----EQVAIKKVFQDKRYKN 7876_Tthe LKIIDVVGNGTFGVVYKKLDDNINFNYLKMKALL---NKE----QVVAVKRVFQDKRYKN GSK3_Spur YTDTRVIGNGSFGVVYQAR-------------MV---DSS----DLVAIKKVLQDKRFKN n1163_Tthe ITLDKIIGNGTFGVVYLAK-------------MN---DTQ----EQVAIKKVFQDKRYKN CC1G_03802_Ccin YTNCKVIGNGSFGVVFQAR-------------LLGVPKDQ----EDIAIKKVLQDKRFKN AqueK117_Aque YTDLKVIGSGSFGVVYQAK-------------IL---ETN----EPIAIKKVLQDKRFKQ GSK_b_Smoe YVAERVVGTGSFGIVFQAK-------------CL---ETG----ETVAIKKVLQDKRYKN GSK_a-2_Smoe YVAERVVGTGSFGIVFQAK-------------CL---ETG----ETVAIKKVLQDKRYKN GSK_a-1_Smoe YVAERVVGTGSFGIVFQAK-------------CL---ETG----ETVAIKKVLQDKRYKN GK035_Glam FTTMRTIGSGSFGVVFIAK-------------T----STG----ELIAIKKVFQDRKYRN GK036_Glam VVPEKVIGKGSFGVVYLVK-------------SL---KGN----TPLALKLVLQDRRYKN .:* GSK3B_Hsap ------RELQIM---RKL-DHCNIVRLR-YFFYSSGE------K---------------- GSK3A_Hsap ------RELQIM---RKL-DHCNIVRLR-YFFYSSGE------K---------------- Pk34A_Dmel ------GEAEIM---GQLKDHNNIVRLI-MHSSVSLG------F---------------- sgg_Dmel ------RELQIM---RKL-EHCNIVKLL-YFFYSSGE------K---------------- gskt_Dmel ------RELQIM---RKL-RHDNIITLK-WFFFSSGE------K---------------- GSK3B_Mmus ------RELQIM---RKL-DHCNIVRLR-YFFYSSGE------K---------------- GSK3A_Mmus ------RELQIM---RKL-DHCNIVRLR-YFFYSSGE------K---------------- R03D7.5_Cele LATSEYPEIQIL---SKL-FHPAISNLL-YFYSRNAND---------------------- F21F3.2_Cele ------FEFIFLTGRERA-KHKNVIHMI-FAFSHSYDT---------------------- C44H4.6_Cele ------RELTIM---HEM-DHPNIIRLL-YYYVM-------------------------- C36B1.10_Cele ------LEVKILGKLGKL-KHKNIVRLL-FSYQKQ--------H---------------- RIM11_Scer ------RELEIM---KML-SHINIIDLK-YFFYERD-------S---------------- MRK1_Scer ------RELETM---KML-CHPNTVGLQ-YYFYEKD-------E---------------- MCK1_Scer ------RELQIL---RIA-DHPNIVKLQ-YFFTHLSP------Q---------------- Y106G6D.4_Cele ------FELLFLSGLRRK-PHKNIVQML-FAFSRNTTSGEGLEM---------------- Y106G6E.1_Cele ------MEVKILGQLGKL-KHRNIVRLL-YSYQKQ--------H---------------- Y18D10A.5_Cele ------RELQIM---RKL-NHPNIVKLK-YFFYSSGE------K---------------- YOL128C_Scer ------LELEIL---QNI-RHPNLVTLE-FFFESHCT------T---------------- GlkA_Ddis ------REYDIL---KIVA-HPNCLRIL-DMFYTAE-------D---------------- GSK-3_Ddis ------RELQIM---KML-NHINIVSLK-NSFYTS--------D---------------- 19912_Tthe ------RELQIM---QEVAHHPNIVQLK-YSFYSFGE------E---------------- 19923_Tthe ------RELQIM---KEIGNHPNVISLR-NYFYIYADD-----K---------------- 19924_Tthe ------RELQMM---KEIGNHPNVIKLR-NHYYSYG-N-----S---------------- 2636_Tthe ------REYEIL---LDIKDCDYVVKMI-DLYYSKT-------D---------------- 5825_Tthe ------REFEII---KSL-NHQNLIKLK-QAYYTTQNN-----N---------------- 7876_Tthe ------REREII---ERL-DHQNIIKCK-DFFETKGE------K---------------- GSK3_Spur ------RELQIM---RRL-DHHNIVKLK-YFFYSSGE------K---------------- n1163_Tthe ------REFEII---KSL-NHQNLIKLK-QAYYTTQNN-----NVDSFFFHTFNSKINSQ CC1G_03802_Ccin ------RELQIM---RLV-SHPNVVDLK-AFFYSNGD------K---------------- AqueK117_Aque ------------------------------------------------------------ GSK_b_Smoe ------RELQIM---RLL-DHPSIVSLK-HCFFSTT-------D---------------- GSK_a-2_Smoe ------RELQIM---RLL-DHPNIVALK-HCFFSTT-------D---------------- GSK_a-1_Smoe ------RELQIM---RLL-DHPNIVALK-HCFFSTT-------D---------------- GK035_Glam ------RELSIM---QELGQHPCIIRLI-NSYISVATN-----Q---------------- GK036_Glam ------REFQIM---RTL-VHPCICRLVKGTFIPSIS------S---------------- GSK3B_Hsap ------------------------------------------------------------ GSK3A_Hsap ------------------------------------------------------------ Pk34A_Dmel ------------------------------------------------------------ sgg_Dmel ------------------------------------------------------------ gskt_Dmel ------------------------------------------------------------ GSK3B_Mmus ------------------------------------------------------------ GSK3A_Mmus ------------------------------------------------------------ R03D7.5_Cele ------------------------------------------------------------ F21F3.2_Cele ------------------------------------------------------------ C44H4.6_Cele ------------------------------------------------------------ C36B1.10_Cele ------------------------------------------------------------ RIM11_Scer ------------------------------------------------------------ MRK1_Scer ------------------------------------------------------------ MCK1_Scer ------------------------------------------------------------ Y106G6D.4_Cele ------------------------------------------------------------ Y106G6E.1_Cele ------------------------------------------------------------ Y18D10A.5_Cele ------------------------------------------------------------ YOL128C_Scer ------------------------------------------------------------ GlkA_Ddis ------------------------------------------------------------ GSK-3_Ddis ------------------------------------------------------------ 19912_Tthe ------------------------------------------------------------ 19923_Tthe ------------------------------------------------------------ 19924_Tthe ------------------------------------------------------------ 2636_Tthe ------------------------------------------------------------ 5825_Tthe ------------------------------------------------------------ 7876_Tthe ------------------------------------------------------------ GSK3_Spur ------------------------------------------------------------ n1163_Tthe LRFFLRYKKTQNCLHSLIQFTRYIQKHSKKSNTKTLIQIFNLRELDFPASHPVFYTNPIL CC1G_03802_Ccin ------------------------------------------------------------ AqueK117_Aque ------------------------------------------------------------ GSK_b_Smoe ------------------------------------------------------------ GSK_a-2_Smoe ------------------------------------------------------------ GSK_a-1_Smoe ------------------------------------------------------------ GK035_Glam ------------------------------------------------------------ GK036_Glam ------------------------------------------------------------ GSK3B_Hsap --------KDE--VY-LNLVLDYVPETVYRVARHYSR-------AKQTLPVIYVKLYMYQ GSK3A_Hsap --------KDE--LY-LNLVLEYVPETVYRVARHFTK-------AKLTIPILYVKVYMYQ Pk34A_Dmel --------PSV--DY-VLLVMEYMPMTLLDYINYHLTV------LQPAERLINVRILSYQ sgg_Dmel --------RDE--VF-LNLVLEYIPETVYKVARQYAK-------TKQTIPINFIRLYMYQ gskt_Dmel --------RDE--VY-LNLVMEFLPETLYKVERQYAR-------AKQTLPVNFVRLYMYQ GSK3B_Mmus --------KDE--VY-LNLVLDYVPETVYRVARHYSR-------AKQTLPVIYVKLYMYQ GSK3A_Mmus --------KDE--LY-LNLVLEYVPETVYRVARHFTK-------AKLITPIIYIKVYMYQ R03D7.5_Cele ----------K--VI-NCLVLDYLPQDLARLRDQ-----------GVKFDVLDAKLYTFQ F21F3.2_Cele ----------K--VC-ESYVFDFMPNTLAEVIR-------------QKLTDLDIRLYTWQ C44H4.6_Cele --------QQE--NC-LNFVMEFMPKDLAYVHRQFAH-------NDKQMPAYSIKLYMFQ C36B1.10_Cele --------EGR--IC-LGLIFEYIPMNLHQFLKDNN----------RRVDIIEVKLIVWQ RIM11_Scer --------QDE--IY-LNLILEYMPQSLYQRLRHFVH-------QRTPMSRLEIKYYMFQ MRK1_Scer --------EDE--VY-LNLVLDYMPQSLYQRLRHFVN-------LKMQMPRVEIKFYAYQ MCK1_Scer --------DNK--VY-QHLAMECLPETLQIEINRYVT-------NKLEMPLKHIRLYTYQ Y106G6D.4_Cele --------KHS--FC-ESYVFGFMPYTLQNILKK------------TRLAEVDMKLYTWQ Y106G6E.1_Cele --------EGR--IC-LALIFEYIPLNLYQFLKDKN----------RRIDIVEVKLIVWQ Y18D10A.5_Cele --------KDE--LY-LNLILEYVPETVYRVARHYSK-------QRQQIPMIYVKLYMYQ YOL128C_Scer --------KDGGHLYQKNFVMEYIPQTLSSEIHEYFD-------NGSKMPTKHIKLYTFQ GlkA_Ddis ---------NK--KM-QNLVFDFIPYTLASLLK------------KRQLSINFIKVLFYQ GSK-3_Ddis --------NDE--VY-LNLVLEYVPDTVYRVSRHYSM-------SKQPVPNIFVKLYIYQ 19912_Tthe --------EDD--VY-LNLIMEYVPSNLTKMIKYYHRKKLKQFEQREQFPNILIKLYLYQ 19923_Tthe --------QED--VY-LNIIMDYIPETLYRMIKYFAKK------SKGNFPNILLKLYSYQ 19924_Tthe --------TDD--VY-LHLVMDFVPETLYKMIKYYSKK------HKGNFPNILLKYYSYQ 2636_Tthe --------DNK--LI-QNIVFEYMENNLEDHISKFNK-------SKKVIPEQTVKEYAYQ 5825_Tthe --------PDE--VY-LNIVMEYVPETLSKVIRTYRK-------SKQPFPPLLLKVFSYQ 7876_Tthe --------KDE--VY-LNLVMEFMNFPLSKVIRDKRK-------ANQVMRIEDIRLYAYQ GSK3_Spur --------KDE--VF-LNLVLEYVPETVYRVARHYSK-------AKQTIANLYVKLYMYQ n1163_Tthe TRRYSTVIPDE--VY-LNIVMEYVPETLSKVIRTYRK-------SKQPFPPLLLKVFSYQ CC1G_03802_Ccin --------KDE--VY-LNLVLEYVPETVYRASRHYSK-------LKQPMPMLQIKLYMYQ AqueK117_Aque --------KDE--VY-LNLVLDYIPDTVYRVIRHHYK-------AKQIMPMLFIKLYMYQ GSK_b_Smoe --------KDE--LY-LNLVLEYVPETVYRIAKHYNR-------MNQRMPLLYVKLYTYQ GSK_a-2_Smoe --------KDE--LY-LNLVLEYVPETVYRIAKHHNR-------MNQRMPLLYVKLYTYQ GSK_a-1_Smoe --------KDE--LY-LNLVLEYVPETVYRIAKHHNR-------MNQRMPLLYVKLYTYQ GK035_Glam --------TNG--DF-LNILMDYYQENGYQIYKSYIR-------AGIKMPMFHIKLYTFQ GK036_Glam --------PDD--LI-LYLLMDYYPETIHSIYRQYSR-------LRQHVPLLIVRLITYQ : : :* GSK3B_Hsap LFRSLAYIHS-FGICHRDIKPQNLLLDPD--TAVLKLCDFGSAKQLVRG----------- GSK3A_Hsap LFRSLAYIHS-QGVCHRDIKPQNLLVDPD--TAVLKLCDFGSAKQLVRG----------- Pk34A_Dmel MFRGLGYLHL-LGISHRDVKPENLLIDNQ--KMVLKLSDFGSAKLLVPQ----------- sgg_Dmel LFRSLAYIHS-LGICHRDIKPQNLLLDPE--TAVLKLCDFGSAKQLLHG----------- gskt_Dmel LLRSMGYLHS-LGFCHRDIKPQNMLLDSE--TGVLKLCDFGSAKQLISG----------- GSK3B_Mmus LFRSLAYIHS-FGICHRDIKPQNLLLDPD--TAVLKLCDFGSAKQLVRG----------- GSK3A_Mmus LFRSLAYIHS-QGVCHRDIKPQNLLVDPD--TAVLKLCDFGSAKQLVRG----------- R03D7.5_Cele LFCAISHLTS-KNIVHMDIKPQNVVMDRM--AGRLKLADFGNARRLETN----------- F21F3.2_Cele IFSGLKYLEE-HKVVHRDLKPVNILVDHD--TAFLKISDFGSAKIIVKG----------- C44H4.6_Cele LLRGIGFLHL-HNIVHRDIKPKNLLVDES--NGILKICDFGSAKRLEKN----------- C36B1.10_Cele LFRGQAHLEK-SEICHRDIKPQNLLYNAD--TGLLKISDYGSSAIESVK----------- RIM11_Scer LFKSLNYLHHFANVCHRDIKPQNLLVDPE--TWSLKLCDFGSAKQLKPT----------- MRK1_Scer LFKALNYLHNVPRICHRDIKPQNLLVDPT--TFSFKICDFGSAKCLKPD----------- MCK1_Scer IARGMLYLHG-LGVCHRDIKPSNVLVDPE--TGVLKICDFGSAKKLEHN----------- Y106G6D.4_Cele LFEGIRYLQA-HMIVHRDIKPVNILVDVD--KGTLKIADFGSAKVVLRG----------- Y106G6E.1_Cele LFRGQAHLEK-ADICHRDIKPQNLLYNAE--TGLLKISDFGSSSIQSTK----------- Y18D10A.5_Cele LLRSLAYIHS-IGICHRDIKPQNLLIDPE--SGVLKLCDFGSAKYLVRN----------- YOL128C_Scer ILRALLTLHS-MSICHGDLKPSNILIIPS--SGIAKVCDFGSAQRLDDN----------- GlkA_Ddis LCQAIKHIHS-KAICHRDITPNNILLSS---KGELTLADFGSAKILESN----------- GSK-3_Ddis LCRSINYIHS-LGICHRDIKPQNLLLDTS--TSTLKLCDFGSAKILIKG----------- 19912_Tthe AFRALAYLNG-LNIAHRDIKPSNILINHR--THQLKFCDFGSAKKLSRG----------- 19923_Tthe LMRSLAYIQG-LGICHRDIKPTNVLVDPR--NHALKMCDFGSAKKLNPS----------- 19924_Tthe MLRSLAYIHG-INICHRDIKPQNILVDPR--NHNLKMCDFGSAKKLVPG----------- 2636_Tthe ILKGLQYIHS-KGIAHRDLKPDNILLND---DGKVKICDFGGSKYIDEK----------- 5825_Tthe MFRALAYLKG-IGICHRDIKPQNILCDQK--TMQLKICDFGSAKKLIKG----------- 7876_Tthe MFKALSYLQS-LNICHRDIKPQNILVNDKDDDKRLKICDFGSAKQLIPN----------- GSK3_Spur LFRSLAYIHS-MGICHRDIKPQNLLLNPE--TAVLKLCDFGSAKVLVRG----------- n1163_Tthe MFRALAYLKG-IGICHRDIKPQNILCDQK--TMQLKICDFGSAKKLIKGKLDILFVSYSS CC1G_03802_Ccin LLRSLAYIHS-VGICHRDIKPQNLLLNPS--TGVLKLCDFGSAKILVAG----------- AqueK117_Aque LFRALGYIHA-NGVCHRDIKPQNLLLNPE--TGVLKLCDFGSAKVLVRG----------- GSK_b_Smoe ICRALTYIHGGMGVCHRDIKPQNLLVNPH--THQLKLCDFGSAKVLVKG----------- GSK_a-2_Smoe ICRSLAYIHGGIGVCHRDIKPQNLLVNPH--THQLKLCDFGSAKVLVKG----------- GSK_a-1_Smoe ICRSLAYIHGGIGVCHRDIKPQNLLVNPH--THQLKLCDFGSAKVLVKG----------- GK035_Glam FLRGLAYMHS-FNIANRDLKPQNTLVNRE--SGRAVLCDLGSAKKLNPA----------- GK036_Glam LARSLAYLHY-HNIAHRDCKPTNVLIDPL--TYRCVLCDFGSAKQLVPQ----------- . : . : * .* * : ..* *.: GSK3B_Hsap ---------------------------------------------------EP-NVSYIC GSK3A_Hsap ---------------------------------------------------EP-NVSYIC Pk34A_Dmel ---------------------------------------------------EP-SISYIC sgg_Dmel ---------------------------------------------------EP-NVSYIC gskt_Dmel ---------------------------------------------------EP-NVSYIC GSK3B_Mmus ---------------------------------------------------EP-NVSYIC GSK3A_Mmus ---------------------------------------------------EP-NVSYIC R03D7.5_Cele ---------------------------------------------------EKTGSAYQV F21F3.2_Cele ---------------------------------------------------KA-NNFYQV C44H4.6_Cele ---------------------------------------------------EP-NITYIC C36B1.10_Cele ---------------------------------------------------TP-QQSYHV RIM11_Scer ---------------------------------------------------EP-NVSYIC MRK1_Scer ---------------------------------------------------QP-NVSYIC MCK1_Scer ---------------------------------------------------QP-SISYIC Y106G6D.4_Cele ---------------------------------------------------SS-STSYQV Y106G6E.1_Cele ---------------------------------------------------SP-QQSYHV Y18D10A.5_Cele ---------------------------------------------------EP-NVSYIC YOL128C_Scer ---------------------------------------------------TE-LKTYFC GlkA_Ddis ---------------------------------------------------HT-SMSYIC GSK-3_Ddis ---------------------------------------------------ET-NVSYIC 19912_Tthe ---------------------------------------------------ES-NISYIC 19923_Tthe ---------------------------------------------------ET-NISYIC 19924_Tthe ---------------------------------------------------ES-NISYIC 2636_Tthe ---------------------------------------------------GK-NTPYIV 5825_Tthe ---------------------------------------------------EP-NVSYIC 7876_Tthe ---------------------------------------------------EA-NISYIC GSK3_Spur ---------------------------------------------------EP-NVSYIC n1163_Tthe VVSKNLVFILISSLTAKKQIDYQQFLFKSNKKPKQLLNIQTAPFNKHQKQSEP-NVSYIC CC1G_03802_Ccin ---------------------------------------------------EP-NVSYIC AqueK117_Aque ---------------------------------------------------EP-NVSYIC GSK_b_Smoe ---------------------------------------------------EP-NISYIC GSK_a-2_Smoe ---------------------------------------------------EP-NISYIC GSK_a-1_Smoe ---------------------------------------------------EP-NISYIC GK035_Glam ---------------------------------------------------EP-NIAYIC GK036_Glam ---------------------------------------------------EN-NVAYIC * GSK3B_Hsap SRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGD-SGVDQLVEIIKVLGTPT GSK3A_Hsap SRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGD-SGVDQLVEIIKVLGTPT Pk34A_Dmel SRLYRAPELFAGYELYSCAVDIWSAGCVLAELLKGYPLFSSHKHDRKQLRLIVNMLGTDG sgg_Dmel SRYYRAPELIFGAINYTTKIDVWSAGCVLAELLLGQPIFPGD-SGVDQLVEVIKVLGTPT gskt_Dmel SRYYRAPELIFGSTDYTTKIDMWSAGCVMSELLLGQLIFPGD-SGVDQIVEIVKVMGTPT GSK3B_Mmus SRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGD-SGVDQLVEIIKVLGTPT GSK3A_Mmus SRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGD-SGVDQLVEIIKVLGTPT R03D7.5_Cele TRFYRPPELLFGCEKFTASIDIWSATCVAFELFANRVLFKGK-DTKDQIVLITGVFGYPT F21F3.2_Cele TRFYRPPELLMKAMEYNSTVDVWSAGCIMAEMVKRHVVFPGR-DSAHQLKLYCRCFGAPN C44H4.6_Cele SRYYRAPELIFGSKNYDTSIDTWSVGTVVGELLHNSPIFLAD-SAVDILALQIKAFGTPS C36B1.10_Cele TRYYRPPELLLGSKNYGCKIDTWSCGCVFGELLKGGIFLAGK-SAKNQAEVVFDMFGVPT RIM11_Scer SRYYRAPELIFGATNYTNQIDIWSSGCVMAELLLGQPMFPGE-SGIDQLVEIIKILGTPS MRK1_Scer SRYYRAPELMFGATNYSNQVDVWSSACVIAELLLGKPLFSGE-SGIDQLVEIIKIMGIPT MCK1_Scer SRFYRAPELIIGCTQYTTQIDIWGLGCVMGEMLIGKAIFQGQ-EPLLQLREIAKLLGPPD Y106G6D.4_Cele TRFYRPPELLLDAKEYYWMVDVWSAGCCVGEMMKGKVLFPGA-SIKIMLKLIVQAIGLPS Y106G6E.1_Cele TRYYRPPELILGSKYYGCKIDTWSCGCVFGELLKGGIILAGK-SSNNQAEVIFDMLGYPT Y18D10A.5_Cele SRYYRAPELIFGATNYTNSIDVWSAGTVMAELLLGQPIFPGD-SGVDQLVEIIKVLGTPT YOL128C_Scer SRFYRAPELLLNSKDYTTQIDIWSLGCIIGEMIKGQPLFKGD-SANSQLEEIAKLLGRFP GlkA_Ddis SRYYRAPELLVGCSNYTTKIDIWSIGCILAEMLIGKPLFPGT-NSNDQLGRIIEVLGSPT GSK-3_Ddis SRHYRAPELIFGSTNYTTTIDVWSLGCVLAELLLGQPLFPGE-NGIDQLVEIIKVLGTPT 19912_Tthe SRFYRAPELMLGASNYTTSVDVWSLGCVVAEMLLGEPLFKGN-SSLDQLV---------- 19923_Tthe SRYYRAPELMFMATQYTNSIDVWSVGCVIAEMVLGDPIFAGE-SSVDQLIEIIKILGTPT 19924_Tthe SRCYRAPELMFQATQYTHAIDVWSVGCVIAEMVLGQPIFIGE-SSVDQLIEIIKVLGTPT 2636_Tthe SRYYRAPELILCITKYNQKIDMWSFGCILGELVTTFPLFQGK-TEGDQLFSIFKVLGSPT 5825_Tthe SRYYRAPELIFGAEQYTTAIDTWSIGTVIAEMILGEPLFPGE-NAVEQLVEIIKILGTPT 7876_Tthe SRYYRAPELIFKSQHYTNAIDMWSMGCVIAEMVLGEPLFPGE-NSLDQLVEIIRILGTPT GSK3_Spur SRYYRAPELIFGATDYTCDIDVWSAGCVLAELLLGQPIFPGD-SGVDQLVEIIKVLGTPS n1163_Tthe SRYYRAPELIFGAEQYTTAIDTWSIGTVIAEMILGEPLFPGE-NAVEQLVEIIKILGTPT CC1G_03802_Ccin SRYYRAPELIFGATNYTTNIDIWSTGCVMAELMLGQPLFPGE-SGIDQLVEIIKVLGTPS AqueK117_Aque SRYYRAPELIFGATDYTVNIDIWSAGCVFAELLLGQPIFPGD-SGVDQLVEIIKILGTPT GSK_b_Smoe SRYYRAPELIFGATDYTTAIDIWSTGCVLAELLLGQPLFPGE-SGVDQLVEIIKVLGTPT GSK_a-2_Smoe SRYYRAPELIFGATEYTTAIDIWSMGCVLAELLLGQPLFPGE-SGVDQLVEIIKVLGTPT GSK_a-1_Smoe SRYYRAPELIFGATEYTTAIDIWSMGCVLAELLLGQPLFPGE-SGVDQLVEIIKVLGTPT GK035_Glam SRYYRAPELIFGSRYYTTVIDIWSFGCVVAEMIIGKPIYAGS-SPLDQIIEIIKILGPPS GK036_Glam SRFYRAPELVIGNQNYTCAIDIWSFGCIMAEILLGQPLFPGD-SSIDQLVEIVRVLGSPT :* **.***. : :* *. *:. . . GSK3B_Hsap REQIREMNPNYT--EFKF--------------------------P------QI------- GSK3A_Hsap REQIREMNPNYT--EFKF--------------------------P------QI------- Pk34A_Dmel LERAPEILSKCG--NSLH--------------------------P------RT------- sgg_Dmel REQIREMNPNYT--EFKF--------------------------P------QI------- gskt_Dmel SEQLHDMNPHYK--QFKL--------------------------P------EL------- GSK3B_Mmus REQIREMNPNYT--EFKF--------------------------P------QI------- GSK3A_Mmus REQIREMNPNYT--EFKF--------------------------P------QI------- R03D7.5_Cele DDDIKSIGVKRP--RVARKD--ARGIETVKIKEKTNKTKKEAKQSTLVHEKYT------- F21F3.2_Cele EQDISAMKGEKL--EKEYWK-------------------------------FT------- C44H4.6_Cele KEDMAKWNYEYV--HIPY--------------------------D------TI------- C36B1.10_Cele AEDVSSMNVSNT--KYKEIIQSY-------------------EPD------TSKRTADLA RIM11_Scer KQEICSMNPNYM--EHKF--------------------------P------QI------- MRK1_Scer KDEISGMNPNYE--DHVF--------------------------P------NI------- MCK1_Scer KRFIFFSNPAYD--GPLFSK--P-------------------LFS------GS------- Y106G6D.4_Cele ARDLDYMKVSSM--IDQQSA--------------------------------V------- Y106G6E.1_Cele DSDVSSMKVSST--KLQEVLDSY-------------------EYN------KSKTTADLT Y18D10A.5_Cele REQIQSMNPNYK--EFKF--------------------------P------QI------- YOL128C_Scer KSSIKNSQELQ----DSLND--Q-------------------KFK--------------- GlkA_Ddis KDDMEAMKPSKP--YHL-------------------------QLP------NI------- GSK-3_Ddis KEQIHAMNPYYT--SFKF--------------------------P------EI------- 19912_Tthe ------------------------------------------------------------ 19923_Tthe LQQ--HMNPDHQ--PTQM--------------------------P------KI------- 19924_Tthe QQQIFAMNPDHQ--GTKM--------------------------P------NI------- 2636_Tthe KEEFQKFSERVPFDKKIFD-----------------------EFQ------TY------- 5825_Tthe KEQVQKMNPQHN--QFNF--------------------------P------SI------- 7876_Tthe RQQILMMNPTSQ--EFRF--------------------------P------QI------- GSK3_Spur RDQIKEMNPNYT--EFKF--------------------------P------QI------- n1163_Tthe KEQVQKMNPQHN--QFNF--------------------------P------SI------- CC1G_03802_Ccin REQIKTMNPNYM--EHKF--------------------------P------QI------- AqueK117_Aque KEQIRQMNPNYT--EFKF--------------------------P------QI------- GSK_b_Smoe REEIKCMNPNYT--EFKF--------------------------P------QI------- GSK_a-2_Smoe REEIKCMNPNYT--EFKF--------------------------P------QI------- GSK_a-1_Smoe REEIKCMNPNYT--EFKF--------------------------P------QI------- GK035_Glam LKELKEMNPTLK--EYAF--------------------------P------TI------- GK036_Glam AEEFLAMNPTLK--SVKF--------------------------K------DV------- GSK3B_Hsap -------------K--------AHPWTKDSSGTGHFTSGVRVFR---------------- GSK3A_Hsap -------------K--------AHPWTK-------------VFK---------------- Pk34A_Dmel -------------T--------RPSWNY-------------LLN---------------- sgg_Dmel -------------K--------SHPWQK-------------VFR---------------- gskt_Dmel -------------K--------PHPWSK-------------VFR---------------- GSK3B_Mmus -------------K--------AHPWTKDSPGAGHFTPGVRVFR---------------- GSK3A_Mmus -------------K--------AHPWTK-------------VFK---------------- R03D7.5_Cele -------------RARAMSRSTENKLAP-------------FTS---------------- F21F3.2_Cele -------------K--------GFGLQR-------------LVN---------------- C44H4.6_Cele -------------T--------GVGIQK-------------FIG---------------- C36B1.10_Cele YLYNQTASFQRDRR--------STVYNT-------------KID---------------- RIM11_Scer -------------K--------PIPLSR-------------VFK---------------- MRK1_Scer -------------K--------PITLAE-------------IFK---------------- MCK1_Scer -------------S--------QQRFEK-------------YFG---------------- Y106G6D.4_Cele -------------K--------VIGLKE-------------VLG---------------- Y106G6E.1_Cele YLYTQTVIYQKDRR--------TTVYNT-------------KIE---------------- Y18D10A.5_Cele -------------K--------AHPWNK-------------VFR---------------- YOL128C_Scer ------------------------KFMH-------------WFP---------------- GlkA_Ddis -------------N--------PKFFES--------------LH---------------- GSK-3_Ddis -------------K--------ANPWPR-------------VFK---------------- 19912_Tthe ------------------------------------------------------------ 19923_Tthe -------------K--------PTPWSK-------------VFK---------------- 19924_Tthe -------------K--------PTPWTK-------------VFQ---------------- 2636_Tthe -------------E--------PQNLRK-------------MFF---------------- 5825_Tthe -------------K--------PTSWTK-------------IF----------------- 7876_Tthe -------------K--------SYSWSK-------------VFEKSLQ------------ GSK3_Spur -------------K--------PHPWNK-------------VFR---------------- n1163_Tthe -------------K--------PTSWTK-------------LIKQISTVINKYSNKKQQQ CC1G_03802_Ccin -------------K--------PHPFSK-------------VFR---------------- AqueK117_Aque -------------K--------AHAWNK-------------VFR---------------- GSK_b_Smoe -------------K--------AHPWHK-------------VFH---------------- GSK_a-2_Smoe -------------K--------AHPWHK-------------VFH---------------- GSK_a-1_Smoe -------------K--------AHPWHK-------------VFH---------------- GK035_Glam -------------R--------TTPMSD-------------VLG---------------- GK036_Glam -------------K--------RYPFSK-------------IFR---------------- GSK3B_Hsap -------P-RTPPEAIALCSRLLEYTPTARLTPLEACAHSFF GSK3A_Hsap -------S-RTPPEAIALCSSLLEYTPSSRLSPLEACAHSFF Pk34A_Dmel -------T-AVPQDLCGLLNSCFIYEAAARISPMMACSHGSY sgg_Dmel -------I-RTPTEAINLVSLLLEYTPSARITPLKACAHPFF gskt_Dmel -------I-RTPAEAIDLVSKMLIYSPNARVSPLMGCAHPFF GSK3B_Mmus -------P-RTPPEAIALCSRLLEYTPTARLTPLEACAHSFF GSK3A_Mmus -------SSKTPPEAIALCSSLLEYTPSSRLSPLEACAHSFF R03D7.5_Cele --------KMLDSEIYDFMKATLKIDPKKRKSAIDVLKMPLF F21F3.2_Cele --------D-ISPDQLQFIKRILVYAPEKRLRGKQLLQDDFF C44H4.6_Cele -------R-KLSLSTLELLNSLMKMDPKLRIKPYEALTLPYF C36B1.10_Cele -------YS-DMKDSVELLRQVLVYNPSRRLCGIEFLTNPFF RIM11_Scer -------K-E-DDQTVEFLADVLKYDPLERFNALQCLCSPYF MRK1_Scer -------A-E-DPDTLDLLTKTLKYHPCERLVPLQCLLSSYF MCK1_Scer --------H-SGPDGIDLLMKILVYEPQQRLSPRRILAHQFF Y106G6D.4_Cele --------T-ENQEWADFLGAILRYRPRERLHGPKLLSHPFF Y106G6E.1_Cele -------QD-DMKESVAVLLQILVYNPNKRLSGIEILTHPYF Y18D10A.5_Cele -------V-HTPAEAIDLISKIIEYTPTSRPTPQAACQHAFF YOL128C_Scer --------S-IEFFDVEFLLKVLTYDATERCDARQLMAHEFF GlkA_Ddis -------NV-EDKTVVDLLSKIFIFDPVKRASIDEIIAHP-F GSK-3_Ddis -------AKDVPAESIDLISKILLYDPSSRLKPVEICAHPFF 19912_Tthe -----------------------------------------E 19923_Tthe -------NCKVDPLAIDLISKVLVYSPQLRLKPLEALAHPFF 19924_Tthe -------NCRIDPLAIDLISKILVYNPEKRLKPLEALLHPFF 2636_Tthe -------YIKDIDNLMDLITKCLQYLPENRITADEALQHPFF 5825_Tthe ------AKQKPDPMLIDLISRLLVFVPTDRPTPLETLLHPYF 7876_Tthe --KVSEDEKQKFNQLMDLISRVLVYAPSERPSPLQALAHPFF GSK3_Spur -------A-RTPADAIQLCSRLLEYTPKSRIKPLEACAHQFF n1163_Tthe NANIF-AKQKPDPMLIDLISRLLVFVPTDRPTPLETLLHPYF CC1G_03802_Ccin -------P-RTAPEAIDLVSKLLEYTPGARLSAVEAMVHPFF AqueK117_Aque -------P-RTPPEAIDLVSRLLEYTPTMRITTLDSCAHSFF GSK_b_Smoe -------K-RMPPEAVDLVSRLLQYSPSLRCNALEALVHPFF GSK_a-2_Smoe -------K-RMPPEAVDLVSRLLQYSPNLRCSSLEALAHPFF GSK_a-1_Smoe -------K-RMPPEAVDLVSRLLQYSPNLRCSSLEALAHPFF GK035_Glam -------T-K-DPVVLDFFARCFKYSPNERITAYEALAHPFY GK036_Glam -------S-KAHTDAVDLLTKVLVYDPKKRPTAMEILAHPFY