CLUSTAL W (1.83) multiple sequence alignment Haspin_Hsap LQR-CEKIGEGVFGEVFQTIADH------------------------------------- Haspin_Dmel LLN-TKKIGEGAYGEVFRCSRNQEVLK--------------------------------- Haspin_Mmus LER-CEKIGEGVFGEVFQIINDQ------------------------------------- K08B4.5_Cele IKV-LKLLGSGDSGDVYAVTWMG------------------------------------- H12I13.1_Cele IEL-QRKIGFGAYGSAYSVKYGG------------------------------------- F22H10.5_Cele SKN-IAKIGEGCYAEAFSTIFNN------------------------------------- C50H2.7_Cele VTL-HEKIGAGQSGMAFSATWKK------------------------------------- C04G2.10_Cele LVV-EGKLGEGLRGIAYKVKHRN------------------------------------- C01H6.9_Cele GRR-VKKLGEGAYGEVFSTIWDG------------------------------------- aSWK213_Cele ARK-VKKLGEGAYGEVFSTVWNG------------------------------------- T05E8.2_Cele IEA-KSKLGFGQTGDVLQIERSG------------------------------------- Y40A1A.1_Cele YAN-VAKVGEGCFAEAFSTTFKN------------------------------------- Y48B6A.10_Cele -----QKLGGGIAGDAFNCTWKG------------------------------------- Y73B6A.1_Cele TGK-VEKLGQGNHGTIFKVRWNG------------------------------------- ZK177.2_Cele IK---KFLGDGASGTAYLVVWED------------------------------------- DDB0231182_Ddis ---NMQKTG-GRNGSVFFVNNNNNSNNNNNNNNNNNNNNNNNNNNNNNNNNNNDNSNNKN ALK1_Scer ---L-------------------------------------------------------- YBL009W_Scer ------------------------------------------------------------ Haspin_Spur MKK-CVKIGEGVYGEVFRTFNNRK------------------------------------ CC1G_01353_Ccin --E-FRKIGEASYSEVFGI----------------------------------------- AqueK156_Aque MKRTLQKLGEGVFGEVFSCYTPEG------------------------------------ Haspin_Hsap ---------------------TPVAIKIIAIEGPDLVN--------GSHQKTFEEILPEI Haspin_Dmel ---DHI---------------SDIVLKIIPLEGSTVIN--------GEKQKTFSQILPEI Haspin_Mmus ---------------------APVALKIIAIEGLDLVN--------GSHQKTFEEILPEI K08B4.5_Cele ---------------------TEYTLKLAKSNNSKTK----------------SEQLVEV H12I13.1_Cele ---------------------KTVVMKLIGIRDN--E----------------QLLFNEL F22H10.5_Cele ---------------------QSVVMKVLPCRDISNGEK------CGEHTQGIDAVIAEL C50H2.7_Cele ---------------------KKVVVKIDPIPNTDVK----------------NDQQKEI C04G2.10_Cele ---------------------TMKCLKLLPLSWTSRN----------------KEALEDL C01H6.9_Cele ---------------------KPVAIKIVPFEKDGCNRQYFGEY-HSEEMQTSDVVLPEV aSWK213_Cele ---------------------RPVAIKVLPFENNGCFYG---N--QSVEIPTTHAVLSEV T05E8.2_Cele ---------------------RSEALKMCRLAGPDTV----------------QNAYKEL Y40A1A.1_Cele ---------------------VSVVVKVLPLRDGPIGKD------CDEYVQRTEAVLAEL Y48B6A.10_Cele ---------------------LERVAKIIPLHPSHRN----------------KKAFQEV Y73B6A.1_Cele ---------------------RRAAMKVLHVPGEISA----------------DTAKDEI ZK177.2_Cele ---------------------KEVVMKVTGIHPQS-I----------------SVLHDEL DDB0231182_Ddis NFKNNNTSYTHNSNKNNNENKNTFAIKQQLVS--------------TPK-NKLSQTYREK ALK1_Scer ------------------------------------------------------------ YBL009W_Scer ------------------------------------------------------------ Haspin_Spur ---------------------SSVALKIIPVEG--------------------------- CC1G_01353_Ccin ---------------------ADVVLKVIPLRDESAPGAISTELEEGPPPSDAQDVRKEI AqueK156_Aque ---------------------DGLAVKIMPIEGKELIN--------DEKQKTFEEILPEM Haspin_Hsap IISKELSLLSGE-VCNRTEGFIGLNSVHCVQG-----------------------S---- Haspin_Dmel IITKKMCSLRTS-KTNSTNGFVSIQKVSLVKG-----------------------R---- Haspin_Mmus IISKELSLLSSE-AYNRTEGFIGLNSVHCVQG-----------------------L---- K08B4.5_Cele QNMAKIQKVL-----PDAPNFPECLEAYFIND---------------------------- H12I13.1_Cele IITQQLGKLAKN---RVCPNFLEYCGSHVMTD---------------------------- F22H10.5_Cele AILKSLSALSTKNHANVTENFVKMVMAKVVIG-----------------------K---- C50H2.7_Cele RNLLKMGRIK-----QMTPNVMRLLKACFVEQ---------------------------- C04G2.10_Cele VALRSLKTIK-----KETPNYLTFFDSFVLTN---------------------------- C01H6.9_Cele IVMKELSALRDEDAWNSTPNFIEMISAEVVMG-----------------------K---- aSWK213_Cele IVMKELSALRDPNSWNSTPNFIEMISAQIVMG-----------------------E---- T05E8.2_Cele KIWQSIKAIQ-----MATPNFPDFYGSCVIKE---------------------------- Y40A1A.1_Cele IVLKLLSALSTKNRPNVTENFVKLVMTKVVVG-----------------------K---- Y48B6A.10_Cele AALNRLGDVA-----HQTPNLVKFEMAAVVTG---------------------------- Y73B6A.1_Cele TVMKKVGSAVFR---KKNPSFLEFLGAYLVEG---------------------------- ZK177.2_Cele LITQKIGKLS-----KSCHNFLPYHGSIVISD---------------------------- DDB0231182_Ddis VILEHLNILIESNKACNFPKLINWYKAAPTSNLSNVNNNNSNNNNNNSNNNITNSRYGSN ALK1_Scer ------------------------------------------------------------ YBL009W_Scer ------------------------------------------------------------ Haspin_Spur ------------------------------------------------------------ CC1G_01353_Ccin IVTRAMGEV--------YGGFVKFLKTYIVRG-----------------------K---- AqueK156_Aque VISK----L------------------GIGKG-----------------------K---- Haspin_Hsap ----YPPLLLKAWDHYNSTKGSA---------------NDRPDFFK-D--DQLFIV--LE Haspin_Dmel ----YPPHFIKLWEKYDNEKGSE---------------NDHPELFG-D--NQLFAV--LE Haspin_Mmus ----YPPLLLKAWDHYNTTKRSA---------------NDRPDFFQ-E--DQLFII--LE K08B4.5_Cele ----IPTEICQ----------------------------KLQ--SSAKVRVDNYCR---I H12I13.1_Cele ----VPV-------------------------------GMRRDP---K--AIRHLAI--L F22H10.5_Cele ----HPTSLLKAWDTYRVEEESE---------------NIRPSKFN-K--NQLYLV--LI C50H2.7_Cele ----IPDEVCD----------------------------EFH--LK-K--DTEHMI--LI C04G2.10_Cele ----LPASTQD------KL--NQ----------------LDPQC---P--ATHYLGL--L C01H6.9_Cele ----YPKGLLSAWDSYDKLKESE---------------NTRPDVYSSI--DQNFIL--FV aSWK213_Cele ----YPKGLLRAWDAYDKLNESE---------------HLRPDVYSSE--HQNFIL--FV T05E8.2_Cele ----VQGNVEK----------------------------LLR--HAGK----VYCG--IF Y40A1A.1_Cele ----YPTSLLKAWDKFRVEEQSG---------------NIRPSKFK-K--NQLYLL--LI Y48B6A.10_Cele ----MPQDVKN----------------------------QLR--ENWR--TNHMLV--VI Y73B6A.1_Cele ----HSKTDPK-----LQF-KNK---------------NGHPLP---E--KAQFVAIFME ZK177.2_Cele ----LPAKMM-------------------------------R--NS-E--CVNHLA--IF DDB0231182_Ddis YEDIYDDNYYDEVDDYDSGKEEEESTKTITKTITTTTASIKPN----I--QYMHL--ILE ALK1_Scer -----------------------------------------------------YL--YLL YBL009W_Scer ------------------------------------------------------------ Haspin_Spur ------------------------------------------------------------ CC1G_01353_Ccin ----YPELLLNLWDEYNETKGSE---------------SMRPDTFK-L--SQVYAI--IV AqueK156_Aque ----YPEFLINAWDNWDEKEESD---------------NDRPDVFS-P--KQLYVM--FA Haspin_Hsap FEFGGIDLE-----QMR--TK---LSSLATAKSILHQLTASLAVAEASLRFEHRDLHWGN Haspin_Dmel LKFAGSDMA-----NFK--FL-----NSEQSYYALQQIILALAVGEEEYQFEHRDLHLGN Haspin_Mmus FEFGGVDLE-----RMK--TK---LSSVATAKSILHQITASLAVAEASLHFEHRDLHWGN K08B4.5_Cele VEYESKTLT-----PVRRRPN---P--------------PFTQSGKKENGFWHEDLHKGN H12I13.1_Cele MARGGGVLD-----NWK--F-----KDYRQCVSVFCQLVMSLKVVKDSINMVHRDIHLWN F22H10.5_Cele LSKGGTALE-----KFK--M-----ESIDQFHSIMQQLVYSLAIAETELQFEHRDLHLGN C50H2.7_Cele TKDGGMPIS-----KIK--PL-----SDSQVLSVLSQILLSLYIGKRELQFSHNDLNPGN C04G2.10_Cele VELGSNSLD-----NTM--L-----TTAVEGLSIVKQLVLSLVIAKRRLDTNHNDVHPGN C01H6.9_Cele SANGGIALE-----DFV--LE-----SENELFSIIHQLVLSMNAAEAALEFEHRDLHLGN aSWK213_Cele SANGGISLA-----DFV--LE-----SEDELFSIIHQLVLSMVAAEAALEFEHRDLNLSN T05E8.2_Cele SEICKKRLD-----NIR--RN---SLTCSESVAIMQQLVLTLAIAKDRILLNHRDLFGGN Y40A1A.1_Cele MSNGGTPLE-----KFE--M-----DNIGQFCSIIQQLLFSLAIAEKEMQFEHRDLHLGN Y48B6A.10_Cele LSRGGRPVA-----SQP--PD---SLTAQQSIGIMKQFVMTMLIGETSLKLYHNDAHCRN Y73B6A.1_Cele LVEGGRSIG-----DFP--F-----KTDNERKSFVCQLVVGLMTAQKELGFSHGDLSVDN ZK177.2_Cele MGYGGTVLA-----DWR--TS-----DYRRCITIMAQLVLAMRIANDKMKFVHGDIYMMN DDB0231182_Ddis YANMGTLKEYGKDNNFE--------FTISQMKSLLFQVIYSLAISQKEFEFVHNDLHFGN ALK1_Scer FKDHGTPIS-----LIS--L-----KNWKQILKIFWSCAGIIHGLEKNLKFEHRNLTLDN YBL009W_Scer --------------------------DYSQALSIFWQCSSILYVAESKFQLEHRNLTLDH Haspin_Spur ------------------------------------------------------------ CC1G_01353_Ccin LPNGGPDLE-----AYS--FNNPTKQGWKQACSIFWQVAKSLAHAEHLVSFEHRDLHWGQ AqueK156_Aque FENSGCALE-----AFT-------FHSKREAMSVLAQIAATLAVGEAALKFEHRDMHRGN Haspin_Hsap VLLKKTS--LKKLHY---TLNGK-------S-S-TIPSCGLQVSIIDYTLSRLE------ Haspin_Dmel ILIEYTN--KKHIVC---TFKSS-------N-L-TLLSKGVNVTIIDYTLSRVT------ Haspin_Mmus VLLKKTN--LKELRY---TLNGK-------T-S-TIPTHGLQVNIIDYTLSRLE------ K08B4.5_Cele ILLAVTD--KDFIKY---RVDKK-------L-I-KLRTNGLMETSLTSCSYRI------- H12I13.1_Cele VLVSRTK--TTCLDY---SMDGK---------V-KLNSYGVVMHLIDFSKSLYG------ F22H10.5_Cele VLIDKTG--AEELEF---VLNNR-------P-V-RIKLRGVRVTIIDFTWSRIQ------ C50H2.7_Cele LLISETK--KKSISY---KKDGK-------S-I-KIKSHGRFLTLIDLQKSTFD------ C04G2.10_Cele VLVKRSAS-PKTLKY---TLDGK-------V-I-RIPSHGLVVGIIDFSEASFG------ C01H6.9_Cele VLIDRNG--VKELYY---TVHGQ-------K-V-PLSTHGIKVNIIDFTLSRIS------ aSWK213_Cele VLIDRNG--VEELSY---TVHGQ-------K-I-PLRTHGIKVNIIDFTLSRIS------ T05E8.2_Cele VLIKVTG--KTNLHY---THNGV-------K-I-TLMRKAMLCILLILDKVQLAVKVVKL Y40A1A.1_Cele VLIKKQV--WESTQ---------------------------------------------- Y48B6A.10_Cele VLLTDTD--DEYLEY---KPDGG-------A-V-KVKSYEKKLTIID------------- Y73B6A.1_Cele TIVTKTK--LRTVAY---ILEGK-------A-V-KLKTSGVLLKIIDYGKSECS------ ZK177.2_Cele ILIAPTT--KRWIEY---NIDGK-------T-I-TIQTFGIIPQLIDFSKSWCG------ DDB0231182_Ddis VLLTSFPVDKKYIVY---QDK-----LDNGEFNNWIVGGDFIVKISDFGLSRIK------ ALK1_Scer ILIDGNG----------------------------------NITIIDFKCSRLQ------ YBL009W_Scer ILIDSKG----------------------------------NVTLIDMKCCRFL------ Haspin_Spur ------------------------------------------------------------ CC1G_01353_Ccin ILVKNVP--SQKPKLQPINVNGVKSRKQRLM-M-DDKSHGVQTTIIDLGLSRMD------ AqueK156_Aque ILVRRTK--EEKMVF---VIDSH-------K-Y-VLPSEGVHVTVIDYTLSRLS------ Haspin_Hsap -------------------------------------------------RD-GIVV-FCD Haspin_Dmel -------------------------------------------------IN-DCCY-FND Haspin_Mmus -------------------------------------------------RD-GIVV-FCD K08B4.5_Cele ------------------------------------------------MKE-L------- H12I13.1_Cele -------------------------------------------------GQ-NKKT-NED F22H10.5_Cele -------------------------------------------------EG-GKTI-YVD C50H2.7_Cele -------------------------------------------------EK-ED-K-GLD C04G2.10_Cele -------------------------------------------------RA-NGNS---D C01H6.9_Cele -------------------------------------------------KG-ATTV-YWD aSWK213_Cele -------------------------------------------------KD-STTI-YWD T05E8.2_Cele PKNPKTDYTLEFFLWKTSIGIGFSIPKNRCTYNFILIAQKLRANERKVEKS-TAQL-LWD Y40A1A.1_Cele ------------------------------------------------------II-YED Y48B6A.10_Cele ------------------------------------------------------------ Y73B6A.1_Cele -------------------------------------------------SD-NKAS-TS- ZK177.2_Cele -------------------------------------------------AD-P--E-RHD DDB0231182_Ddis -------------------------------------------------LP-SNEIIYNQ ALK1_Scer -------------------------------------------------TPQ-DDVLYLR YBL009W_Scer -------------------------------------------------NIDNNKASYTR Haspin_Spur ------------------------------------------------------------ CC1G_01353_Ccin -------------------------------------------------AG-DGSG-GYR AqueK156_Aque -------------------------------------------------QG-SCTS-YND Haspin_Hsap ---VSMDED-LFTG---------DGDYQFD----IY---RLMKKEN---N--NR------ Haspin_Dmel ---LSRDEE-LFQA---------TGDYQYD----VY---RMMRNEL---R--NN------ Haspin_Mmus ---ISAEED-LFTG---------EGDYQFE----IY---RLMRKEN---K--NC------ K08B4.5_Cele ------SKK-LFEA---------KTIEEFW----NY---QDLLESV---I---------- H12I13.1_Cele ---MNDLKY-VAVL---------IVDNLKGKEED----KEKLRQAFINVP--SARTLEEL F22H10.5_Cele ---TEIDTA-MFEG---------FSDSQFD----VY---REMRRN--------------- C50H2.7_Cele ---CWKLNS-RV-----------RDQFLPLVKED----TKKILAKV-------------- C04G2.10_Cele ---VGFLSF-ITE--------------------E----ISKTL----------------- C01H6.9_Cele ---LENDPA-IFEG---------QDDPQFE----VY---REMRKNC---K--SN------ aSWK213_Cele ---LEEDTT-IFEG---------PDAPQFE----VY---REMR----------------- T05E8.2_Cele ---TPRFWK-FFTK---------KDTATSDLSYGLPRIGAELMTRT-------------- Y40A1A.1_Cele ---MEKDGA-MFEG---------FGDSQFD----VY---REMRSNC---K--RN------ Y48B6A.10_Cele ------------------------------------------------------------ Y73B6A.1_Cele ---FED--------------------------SD----YTKLRN---------------- ZK177.2_Cele ---ISRLHT-VAKR---------VGHSLNGSKRD----KKKVR-QA-------------- DDB0231182_Ddis ----R------------------------------------------------------- ALK1_Scer ---LDH-PLFFLNGKDKSKINEYQYQFEFE----IY---QSMRILL---N--MD------ YBL009W_Scer ---LDH-HY-FFQG---------RGTLQFE----IY---ELMRSML---PQPIS------ Haspin_Spur ------------------------------------------------------------ CC1G_01353_Ccin VQWTPFDEE-VFMG---------EGEYQFD----VY---RMMRDHT---G--DD------ AqueK156_Aque ---LNNLPW-LFKG---------HGGIQHD----TY---LRMRNAT---K--SD------ Haspin_Hsap --------------WGEYHPYSNVLWLHY--LTDKMLKQMTFKTKCNTPAMKQIKRKIQE Haspin_Dmel --------------WSSFSPKTNIIW---------------------------------- Haspin_Mmus --------------WGEYHPYNNVLWLHY--LTDKILNKMKFKTKCQSAAMKQIRKNLQH K08B4.5_Cele ----------------VIDKPNN----------------------------------INH H12I13.1_Cele KDNIIYRFMVGWMDVLNYAPIDCTCCLENFPAISRVLLT----DKMQYK----INLVIEN F22H10.5_Cele ------------------------------------------------------------ C50H2.7_Cele ---------------------------------------------------------AEE C04G2.10_Cele ------------------------------------------------------------ C01H6.9_Cele --------------WKKFSRRTNLMWIVY--IANRLI----------------------- aSWK213_Cele ------------------------------------------------------------ T05E8.2_Cele ---------------------------------------------------------VT- Y40A1A.1_Cele --------------WQLFSSKSNIMWIKF--IATTI------------------------ Y48B6A.10_Cele ------------------------------------------------------------ Y73B6A.1_Cele ------------------------------------------------------------ ZK177.2_Cele ---------------------------------------------------------VKM DDB0231182_Ddis ------------------------------------------------------------ ALK1_Scer --------------ASAFEPMTNLYWLYY--LSRVLLKFGDRKLGKNDANRDKMARVI-- YBL009W_Scer --------------WATFEPRTNLLWLYH--LSSSLL----------------------- Haspin_Spur ------------------------------------------------------------ CC1G_01353_Ccin --------------WEGYHPLTNVMWLHY--LAT-------------------------- AqueK156_Aque --------------WSKFAPRTNACWLYY--IVNKMAIK----SRVKYVTRAQIQAAFEP Haspin_Hsap FHRTMLNFSSATDLLCQHSLF Haspin_Dmel --------------------L Haspin_Mmus FHRTVLSFSSATDLLCQHSLF K08B4.5_Cele I--------GIL---QDISNL H12I13.1_Cele VIRCLFR--VDI---NTSPVF F22H10.5_Cele -------------------CQ C50H2.7_Cele I--------EKT---TILDWK C04G2.10_Cele ----------SK---AENRTF C01H6.9_Cele -----------------DTKI aSWK213_Cele --------------------E T05E8.2_Cele A--------EKQ---ELKKKF Y40A1A.1_Cele ------------------IRK Y48B6A.10_Cele --------------------F Y73B6A.1_Cele ----------HA---MDVFKV ZK177.2_Cele V----------G---AAKNWK DDB0231182_Ddis ----------ND---RSKEFC ALK1_Scer ----------NH---LEMNLA YBL009W_Scer -----------------KMAK Haspin_Spur --------------------D CC1G_01353_Ccin ------------------KLL AqueK156_Aque LVNQFLNYDSAKD---IFLEY