CLUSTAL W (1.83) multiple sequence alignment LRRK2_Hsap -------------GDGSFGSV-YRAAYEG---------EEVAVKIFNKH----------- LRRK1_Hsap E----DE--GSVLGQGGSGTVIYRARYQG---------QPVAVKRFHIKKF-KNF----- CG5483_Dmel I----IK--GSLLGRGAFGFV-FKANCKSA---------LMAFKVAVG------------ LRRK2_Mmus -------------GDGSFGSV-YRAAYEG---------EEVAVKIFNKH----------- LRRK1_Mmus E----GE--NSILGQGGSGTVIYQARYQG---------QPVAVKRFHIKKF-KNS----- T27C10.5_Cele L----KR--SRMLGRGAFGFV-FRATVRQPNG----ELCEVAQKMLEPVDP-GPG----- GbpC_Ddis V----KI--NKEVGRGAFGIV-YEAEWMS---------EWIALKKLLLPSS-TDT----- Pats1_Ddis L----MI--EELIGEGGAALV-YRARWQG---------QTVAVKKLKTIEN-LDS----- QkgA_Ddis I----LY--ERQIGEGGFGLI-HKGKLISN-------KSDIAIKSLILCNS-NNN----- QkgA_C2d_Ddis I----LY--ERQIGEGGFGLI-HKGKLISN-------KSDIAIKSLILCNS-NNN----- Roco10_Ddis V----FN--APLLGA----------------------------------D---------- Roco11_Ddis V----VC--EEQIGVGGFGLV-HKGKLILQD-----KSLVVAIKSYIVGNS-S------- Roco4_Ddis I----EY--EKQIGKGGFGLV-HKGRLVKD-------KSVVAIKSLILGDS-E------- Roco5_Ddis L----EI--IEKVGEGGFGIV-YKGKLRG---------QLVAIKQITIDSG--------- Roco6_Ddis I----EFESPKLIGRGASGKI-YRANLND---------TMVAVKQLEVVG---------- Roco7_Ddis L----KF--GPQLGSGSYANV-YRGIWNG---------SEVAIKVLNFDD---------- Roco8_Ddis L----IY--QEEIGVGGFSRV-YKGIYKN---------NTVAIKQFNFERM-DL--IDS- Roco9_Ddis FKEVELD--PNPIGEGGTATV-YKGKWRQ---------SDVAIKLLKTDVV--------- LRRKd_Spur M----VS--GQSLGQGGFGEV-FRAKFRG---------ETVAAKTMLPSRLLKNRMFSSA LRRKc_Spur M----VS--GQSLGQGGFGEV-FRAKFRG---------ETVAAKTMFPSRLLKNQMYSSP LRRKb_Spur Q----RA--ENLLGDGSFGSV-YKGTYRD---------KPVAVKVFSKGGE--------- LRRKa_Spur L----EI--QRLLGSGTFGLV-FQGVMARASE----HRRPIAAKMLQPYPP-GQG----- AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque E----DK--DSLLGEGGFGKV-YRGKCRG---------KSVAIKKYLTR----------- AqueK487_Aque I----SK--LEVLGSGGFGSV-YKGLIEEGQ-------VTVAIKEFSSIAG-KME----- AqueK488_Aque ------------VGCGCFGVV-YHKRLQLEQYDP-DISREVAVKEFRSSDM--------- AqueK489_Aque S----------------------------------------------------------- AqueK490_Aque T----VK--KHLF-----------------------------------SE---------- AqueK491_Aque V----DR--GKFVASGSFGEI-YHGAIYPHLSASDDEGREVAIKIDKQD-R--------- AqueK492_Aque E----DK--DSLLGEGGFGKV-YRGKFHG---------KSVAIKKYLTR----------- AqueK493_Aque E----DK--DSLLGEGGFGKV-YRGKFRS---------KSVAIKKYLMR----------- AqueK494_Aque -----------VLGKGGFGEV-FKALYNE---------KSVAIKVFSPRVA-E------- AqueK495_Aque -------------------QV-YKGTYYNQ---------PVAIKVFPIDSS--------- AqueK496_Aque I----LE--KEVLGKGGYGFV-CTGELKGPTGS---PPELVAVKVFLTNLE-GKI----- AqueK497_Aque K----DL--STRLGRGGAGAV-YKGKYRNV---------PVAVKEFLTQSQ-ADA----- AqueK498_Aque V----LK--KERLGRGAFATV-YHAQIKRKLPNGQIHFEDVAIKALGNKGE-D------- LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap -------------------------------------------------AN--------- CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus -------------------------------------------------AN--------- T27C10.5_Cele -----------------------------------------------G-RPSALA----- GbpC_Ddis -----------------------------------------------TNLNGNGE----- Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis -----------------------------------------------NNSNNNNN----- QkgA_C2d_Ddis -----------------------------------------------NNSNNNNN----- Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ---------TSFNNLNSLTISPSNSSLSISLSSSTSSLSPPIVNNNNNNNNLNNNLNNLN Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur SEGYASCAST-----------------------------------SSSTSNRTGE----- LRRKc_Spur SEGYASCAST-----------------------------------PSSTSNMTGE----- LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur -----------------------------------------------A-GNTDRR----- AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque -----------------------------------------------D-SLS-------- AqueK497_Aque -----------------------------------------------F-QDEDEL----- AqueK498_Aque -----------------------------------------------L-DDDDDE----- LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis NNNKLYIQQQQQTQQNQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQNQQQPKILQ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap -------------------------------------------------TSLRLLRQELV LRRK1_Hsap ------------VPA-----------------D--TMLRHL--RATDAMKNFSEFRQEAS CG5483_Dmel ------------------------------------KWDRD--PLQHSCKAYCTARQELA LRRK2_Mmus -------------------------------------------------TSLRLLRQELV LRRK1_Mmus ------------APA-----------------D--TMLRHL--RAMDAMKNFSDFRQEAS T27C10.5_Cele ----------AYKAA-----------------A--DKWKRD--SMEFACRAYCTSRQELS GbpC_Ddis ----------VM-VY-----------------D----DPDQ--LIEDRLRVFREFRHEVY Pats1_Ddis -------------------------------------PIEI--NDISLSKAFNEFRRECW QkgA_Ddis ----------SN-NS-----------------N--NFKNNN--NEDEFIEKFQEFQHEVF QkgA_C2d_Ddis ----------SN-NS-----------------N--NFKNNN--NEDEFIEKFQEFQHEVF Roco10_Ddis -------------------------------------------FQNNCARILSSFRHEAL Roco11_Ddis --------------------------------------------ASDIIRKFQEFHHEMY Roco4_Ddis -------------------------------------------GETEMIEKFQEFQREVF Roco5_Ddis -------------------------------------------QAEAASEIYREFRREVW Roco6_Ddis ---------------------------------------------EDAPRIFSEFRREIH Roco7_Ddis -------------------------------------------GHANTTEKYREFRNEAH Roco8_Ddis RNLSTSSLSSNSSQG-----------------E--DSMNQI---SSGKLNAINEFRREVW Roco9_Ddis --------------------------------------------GSDFSKVFAEYRREIF LRRKd_Spur ----------STSTE----------------------NDSL--EAAMLMESFHKLRNEVA LRRKc_Spur ----------STSTE-----------------N--DSCDSL--EAAMLMDSFHKLRNEVA LRRKb_Spur ------------------------------------------------SHPHRLLRQEVT LRRKa_Spur ----------RYDND-----------------N--TKWHRD--PLRFSCEAYRTARKELS AqueK485_Aque -----------------------------------------------------KLYQDFD AqueK486_Aque -----------------------------------------------TEEAFNELRSEAK AqueK487_Aque -------------------------------------EDTLIGHELNAWDIYINGSREAR AqueK488_Aque --------------------------------------DYD--AELEVVKSYADMRYELN AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque --------------------------------------------SKSYSVPLSAMRQELE AqueK491_Aque --------------------------------------KHF--NMETAAKAYTEIRAEVA AqueK492_Aque -----------------------------------------------QEEAFNELRHEAK AqueK493_Aque -----------------------------------------------QEEAFNELCHEAK AqueK494_Aque ---------------------------------------------LHSTTPNQLIRQEVS AqueK495_Aque ---------------------------------------------ANHFTVLRLHRSELS AqueK496_Aque -------------SA-----------------E--LLEEAA--KDSQLRSAYKEIRQEVN AqueK497_Aque ----------PPGGI-----------------HTYHDDDSI--SSGEALFLYRDMRQEVT AqueK498_Aque ------------DISLDEEEERPGGDDEYDGENARE-PPPI--QRSAIISGFNNLKKELS LRRK2_Hsap VLCHLHHPSLISLLAAGIRPR-MLVMELASKGSLDRL-----LQQDK------------- LRRK1_Hsap MLHALQHPCIVALIGISIHPL-CFALELAPLSSLNTV-----LSENARDSS--------- CG5483_Dmel VLLTLKHPNIVPLVGICIKPL-ALVLELAPLGGLDAL-----LRHYRRSG---------- LRRK2_Mmus VLCHLHHPSLISLLAAGIRPR-MLVMELASKGSLDRL-----LQQDK------------- LRRK1_Mmus MLHALQHPCIVSLIGISIHPL-CFALELAPLGSLNTV-----LSENAKDSS--------- T27C10.5_Cele LLSRMKHPNVIGLVGVCTFPL-SLVVELAPLGALNQL-----LGSHRKAG---------- GbpC_Ddis YMSGLNHPNVMKISGFCIQPL-CMALEYVRYGSLYSL-----LSNSS------------- Pats1_Ddis VMSELEHPNIVQLKGLCLDPL-CIVTEYLPHGNLYSF-----LHKPE------------- QkgA_Ddis IMSNLNHPNIVKLYGLMHNPP-RMVMEYVEHGDLYHL-----CQDKE-RY---------- QkgA_C2d_Ddis IMSNLNHPNIVKLYGLMHNPP-RMVMEYVEHGDLYHL-----CQDKE-RY---------- Roco10_Ddis SLYNFRHSNVLSIIGISMNPI-AIITENPTFGSKGSTTLSEYIQDR-QKH---------- Roco11_Ddis IMSSLNHLNIVKLFGSMQNPP-RMVMEFAPHGDLYHF-----LEKKK------------- Roco4_Ddis IMSNLNHPNIVKLYGLMHNPP-RMVMEFVPCGDLYHR-----LLDKA------------- Roco5_Ddis LSNTLTHPSIVSLKGYCLDPC-CIVMEYIPNGTLYSH-----LRKSF------------- Roco6_Ddis VMSDLKHSNVVNLLGFTLSPF-TMVMEYIDCGDLHKF-----LHSPIGDQ---------- Roco7_Ddis ITGELRHANTVSLMGVSLSPF-CLVTELLQYGDLAKF-----IRNT---A---------- Roco8_Ddis LMSGLSHSNIVLMKGFCFEPY-AIVMEYMDIGSLSSF-----LKKKKEDG---------- Roco9_Ddis CLSSFIHDNILDLKGFCLEPL-AIITEFQSGGNLYDY-----IHDLK------------- LRRKd_Spur IMAKLDHPYIVNLVGVSIRHL-CFAMDYAPLGDLRSY-----LFAEHQSARP---HFVKR LRRKc_Spur IMVKLDHPCIVNLVGVSIRHL-CFAMDYAPLGDLQSY-----LFAEHQSARP---HFVKR LRRKb_Spur VLRHLQHPSLVSMEGVGLNPR-ILVMELAPLGSLNTL-----LASGR------------- LRRKa_Spur IINNLDHPHIVPLLGFCRHPM-CLILELAPQGALDTR-----MENFKRVG---------- AqueK485_Aque LLKNLSTPHIISSLGFHYSVP-VLALELSPLGSVRKY-----LNDGNK------------ AqueK486_Aque VLQESHHPFLVCLVGVSVHPLMALILEEAPMGSFERH-----LIKKS------------- AqueK487_Aque MMHQLQHKNILSLVGLAFQPL-RLILELAPLGDLKNS-----LKPFRQEK---------- AqueK488_Aque KLCMMEHDFVVEFVGLLTNPW-SFILEWAPLMSLEKI-----RKSYEEQFKT-------- AqueK489_Aque ---------------------------------MEDV-----ILEHTI------------ AqueK490_Aque MLSLLSHPNIIKAYGYCFSPP-SLVIERSPLGTLLQK-----LSDNEQ------------ AqueK491_Aque LLKDLDHEYIINFIGLTLQPL-CFMLEWASKGSLHGI-----LQSYYRTD---------- AqueK492_Aque LLQKSYHPSIVCLVGVNVHPLTALILEEAPMGSLDRH-----LIKES------------- AqueK493_Aque LLQKSHHPFIVCLVGVNVHPLTALILEEAPMGSLERH-----LIKES------------- AqueK494_Aque ILSQMDHPNIIGLVGVCLRPKPMLLIEYAELGSLSSF-----SP-Y-------------- AqueK495_Aque VLTNISHQYLISTAGFLTAPL-SIVFPLAPLGSLQDH-----LDLCP------------- AqueK496_Aque FLSTLKHQNITKLIGVRTKPVYCLLLELAPMKSLRSM-----LKDYQLCK---------- AqueK497_Aque VLAQLSHPNIVSILGVSLRPM-CIALELAPMGSLFGI-----LDKKLEAIKTAQADLPTA AqueK498_Aque ILSPLRHPYIIQLFGVSARPL-GLVLELAPKGSLKSL-----LKEYSEAQ---------- LRRK2_Hsap ----------ASLTRTLQHRIALHVADGLRYLHSA--MIIYRDLKPHNVLLFTLYP---- LRRK1_Hsap -----F----IPLGHMLTQKIAYQIASGLAYLHKK--NIIFCDLKSDNILVWSLD----- CG5483_Dmel ----------AHMGPHTFQTLVLQAARAIEYLHRR--RIIYRDLKSENVLVWELPQPHT- LRRK2_Mmus ----------ASLTRTLQHRIALHVADGLRYLHSA--MIIYRDLKPHNVLLFTLYP---- LRRK1_Mmus -----F----MPLGHMLTQKIAYQIASGLAYLHKK--NIIFCDLKSDNILVWSLS----- T27C10.5_Cele ----------TKLSLGVIKESAVQVARALEYLHSA--HIIYRDLKSENVLGWRFPAPF-- GbpC_Ddis ----------IEISWGLRLQIASEIAKGMQHLHSHNPPVIHRDLKSPNILLNGIT----- Pats1_Ddis ----------MEFSWLFRLKVALDISSGMAFLHSSTPPIIHRDLKSPNILLASIN----- QkgA_Ddis ----------ASLGWTLKLRLMIDIAKGIGYMQNQNPPIVHRDLRSPNIFLKSLD----- QkgA_C2d_Ddis ----------ASLGWTLKLRLMIDIAKGIGYMQNQNPPIVHRDLRSPNIFLKSLD----- Roco10_Ddis ----------PEIPWNIKLKIALDIARAMDKLNSHSPPFLLTNLTSSGIILEKSNDHQSS Roco11_Ddis -----------NIKWSFKVRLMLDIAKGIEYLQNQNPPIVHRDLRSPNIFLFSLD----- Roco4_Ddis ----------HPIKWSVKLRLMLDIALGIEYMQNQNPPIVHRDLRSPNIFLQSLD----- Roco5_Ddis ----------SSITWQLKLKIAINIADAIKHMHGFTPKICHRDLKSPNILMLS-D----- Roco6_Ddis ----------LNGNWALILKLALDIAKGMEFLHSVTPPLLHRDLKSPNVLLSMKD----- Roco7_Ddis ----------ETFSWGTVLKLAIDVAKGMNFLHSCKPMIVHRDLKSANILLGGSS----- Roco8_Ddis ----------QVLDWQMLLKIVTDIASGMAFLHNITPPLVHRDLKSPNILLASHP----- Roco9_Ddis ----------NPLDWQLRIKIAKGIAASLQTLHDSRPSVVHRDLKSPNILLSSKD----- LRRKd_Spur NI-VLE----PVLSRMLTYKISLQVASAVGYLHRK--DIIYCDLKTDNILLFSSD----- LRRKc_Spur NI-VLE----PVLSRMLTYKISLQVASAVGFLHSK--DIIYCDLKTDNILLFSSD----- LRRKb_Spur -----------IKNRNLQHRIAMQVAEGLAFLHKN--RIVYRDLKPDNVLIFSLAL---- LRRKa_Spur ----------ARLTPHTLQELVVQVSSAVAYLHSK--DIIYRDLKAENVLVWKFPQPYS- AqueK485_Aque ------------LLQSGVHQIALQVLSAIKY----------------------------- AqueK486_Aque ----------TPIPRLTMFRIAAQVAAALRFLHQH--GIIFRDLKAANVLLWSLD----- AqueK487_Aque ----------IKLNCRTLKQLIYQVADAME------------------------------ AqueK488_Aque -----HKPEYYYLCPVSLYLILLQVCDGLHYLHAPPIGIIHSDLKLSNI----------- AqueK489_Aque -----------SVSPFLRMRIVYQLASALKTLHSL--KIIHRNVCLENIIVYSLS----- AqueK490_Aque -----------KISRLVRFHISCQVASALAYLHKH--NVIYRTLKSDSVLTWSLE----- AqueK491_Aque ----------SKVSPWTLVEAGRQVANGLSYLHSR--NVVYYDLKSPNILVFEFPSADES AqueK492_Aque ----------TPIPRLTMFRIAAQVAAALRFLHQH--GIIFRSLKAANVLLWSLD----- AqueK493_Aque ----------TLIPRLTMFRIAAQAAAALRFLHQH--GIIFRSLKAANVLLWSLD----- AqueK494_Aque ----------STVSPSLKHRIAMQVASALAFLHKN--NIIYRDLKPSNILIFSLSL---- AqueK495_Aque ----------SGIGDKISHVLLHQVAQGLQYLHSL--HIIHRDIKPGNILVWSLT----- AqueK496_Aque ----------LTMEPITLKQCAKQISDGLNYLHTH--QIVHLDMKSPNVLVWEFPIAGMP AqueK497_Aque NIKMPG----GVLGHQISARIALQVALATRYLHKI--GIVYRDLKSDNVLIWSLDV---- AqueK498_Aque ----------THIQSSAMQAVTLQISDALKYLHDL--RIIYRDLKSDNVLVWQFPSPYDV . LRRK2_Hsap ---------------N-AAIIAKIADYGIAQYCCRM-GI---KT-----SEGTPGFRAPE LRRK1_Hsap --------------VK-EHINIKLSDYGISRQSFHE-GA---LG-----VEGTPGYQAPE CG5483_Dmel ----E------D-SPR-NLVHIKIADYGISRQTAPS-GA---KG-----FGGTEGFMAPE LRRK2_Mmus ---------------N-AAIIAKIADYGIAQYCCRM-GI---KT-----SEGTPGFRAPE LRRK1_Mmus --------------AK-EHINIKLSDYGISRQSFHE-GA---LG-----VEGTPGYQAPE T27C10.5_Cele -------------SPQ-TDVLLKLGDYGISRSVLPSGGA---KG-----FGGTEGFMAPE GbpC_Ddis --------------EG-QNSVATIIDFGTSTALYGG-AA---LI----RCVDQPLWLGPE Pats1_Ddis --------------EN-AQTIAKVVDFGLSGLQHTI--T---N-----RGVENPLWLAPE QkgA_Ddis --------------EN-SPVCAKIADFGLSQQSV-Y-SV---SG-----LLGNFQWMAPE QkgA_C2d_Ddis --------------EN-SPVCAKIADFGLSQQSV-Y-SV---SG-----LLGNFQWMAPE Roco10_Ddis -GNGL--------EIE-PFVNAKIIDFSQSSFLPSL--F---PT-----STTPKSYHSPE Roco11_Ddis --------------EN-APVCAKVADFGLSQQSL-Y-SV---SG-----LLGNFQWMAPE Roco4_Ddis --------------EN-APVCAKVADFGLSQQSV-H-SV---SG-----LLGNFQWMAPE Roco5_Ddis --------------MN-AAVVCKVSDFGETRAVVTS-AL---GR----DKLSNPIWLSPE Roco6_Ddis -----------------GVYTAKVGDFGLSSRMFIQ-AL---KHKLRNFPVGNITWVAPE Roco7_Ddis --------------M--DNLVAKVGDFGLSIKPIGK-EV---KG----RKVWNWRWLAPE Roco8_Ddis --------------TNPNEISAKVSDFGLSRSIVQN-FS---SK-----VVDNPTWQSPE Roco9_Ddis --------------S--LTMECHLCDFSLSGFSTTV--A---N-----RSVQNPVWLAPE LRRKd_Spur --------------VN-EDVNIKLIDYGISKKYDLM-GA---MG-----MAGTPGFCAPE LRRKc_Spur --------------VN-EDVNIKLTDYGISRKYDLM-GA---MG-----MAGPPGFCAPE LRRKb_Spur ---------------G-TLQNAKISDYGISRFATPY-GL---KS-----SEGTPGYRAPE LRRKa_Spur ----P--------NPA-DPIKVKLADYGISVTALPS-GT---KG-----YGGTPGYMAPE AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque --------------ET-SLCH--------------------------------------- AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque --------------LD-EQVNIKLGGFSRSCLEMSQ-GL----A-----VGEHGRFPAPE AqueK490_Aque --------------FE-DEVSVKLAHFDRAAFSTPT-GI---LS-----KTDFSFYPAPE AqueK491_Aque LRVSLESSPVLDKLG-KFPVHVKITDLGISRKITPG-GV---VG-----YKGTPAFMAPE AqueK492_Aque --------------ET-SLCHSKLTDFGIATHLAPL-GV---MG-----IQGDKCVIAPE AqueK493_Aque --------------ET-SLCHSKLTDFGIATHLAPL-GV---MG-----IQGDKSVIAPE AqueK494_Aque ---------------N-SPVNAKLSDYGISTFATTT-GL---NQ-----DIGTAGYKAPE AqueK495_Aque --------------LS-DGILVKITDYGSSYYIDTF-GC---KG-----SRGTEDYMAPE AqueK496_Aque RKERL--------KYA-GNVWLKIADYGISQVATSM-MMKVTTN-----QPGTPGYMAPE AqueK497_Aque ---------------N-ESVNAKLADYGISRFANPG-GI---KG-----EEGTPGYMAPE AqueK498_Aque LVPAL------P-VHT-DVVKVKLSDYGISQFASTQ-GA---KG-----LVGTPGFMAPE LRRK2_Hsap VAR--G-NVIYNQQADVYSFGLLLYDILTTGGRIVEGLK------------------FPN LRRK1_Hsap IRP----RIVYDEKVDMFSYGMVLYELLSGQ-RPALGHH---Q----------------L CG5483_Dmel IIRYNG-EEEYTEKVDCFSFGMFIYENISLR-QPFEGHE--------------------- LRRK2_Mmus VAR--G-NVIYNQQADVYSFGLLLHDIWTTGSRIMEGLR------------------FPN LRRK1_Mmus IRP----RIVYDEKVDMFSYGMVLYELLSGQ-RPALGHH---Q----------------L T27C10.5_Cele IVRFNG-EEEYTQKVDCFSFGMFLYELLTLK-FPFESEE--------------------- GbpC_Ddis VLAG----TAYSEPSDVYSFGIILWELYTRA-HPFDEFQ-FGQ--------------WMS Pats1_Ddis ILNK---TKEASTQTDVYAFGVILWELVTRK-DYFGEIG-F-----------------MT QkgA_Ddis TIGV--EDESYTEKVDTYSFAMILFTILTGE-IPFDEYS-FGKM---------------Q QkgA_C2d_Ddis TIGV--EDESYTEKVDTYSFAMILFTILTGE-IPFDEYS-FGKM---------------Q Roco10_Ddis VLQ----KLNYHENSDVYSFGIILYELLTRS-IAFQDHD-----R--------------- Roco11_Ddis TIG---AEESYTEKIDTYSFSMILFTILTGE-CPFDEFTSFGKM---------------E Roco4_Ddis TIGA--EEESYTEKADTYSFAMILYTILTGE-GPFDEYS-YGKI---------------K Roco5_Ddis IMRG----DEYTEKADVYSFGIVLWEILTGL-LPFDEYP-VAHSS------------FMY Roco6_Ddis ILR----EEEYTVKSDVYAFGLILHELLTRK-HPYREFN-YSMV---------------S Roco7_Ddis CMG----DGQYTEKIDIYSYAIVLWEIITRD-LPFEEYVD--QLK------------WNS Roco8_Ddis VLK----GMEYNEKSDIYSFGMILWECYHLE-LPFDEFD-F-K--------------FMS Roco9_Ddis VINN----ELCSDKSDVYAYGVILFELLSRT-RFFSNIT-F-----------------MS LRRKd_Spur ILQ----GKTFDEKVDWFSYGMFLYHLMTGL-VPYYDQH-S-R----------------I LRRKc_Spur ILQ----GKVFDEKVDWFSYGMFLYHLMTGL-VPYYDQH-S-R----------------I LRRKb_Spur VIR--G-TSNYNTEVDIYSFGILLYELVSEGHRPFEEME------------------FRT LRRKa_Spur IVQYDG-KETYNEKVDCFSFGMFMFELMSLQ-RPFECLVGKDVGR------------LSE AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque MSNY---LYEYDQRADVFSFAFTSYEILTRK-KL-KCRK---G----------------V AqueK490_Aque MVRY-EFSEEYTEKVDIYSFGILLYELVARW-QPFTSDK-T-A----------------- AqueK491_Aque ILRYV-GKEACTEKVDVFSFGMFMYELLAQQ-FPFERQ---------------------- AqueK492_Aque VLYIGQKRTIYNHKADIFSFGMLLYQMIARR-HPFHNVQ-P------------------V AqueK493_Aque VLYIGQKRTIYNHKADIFSFGMLLYQMIARR-HPFHNVQ-P------------------V AqueK494_Aque ILKAKTSKMPYNTMVDIYSFGIVLFQLVTDGHTPFEELMP-------------------H AqueK495_Aque LYLSA-RKRNYDEKVDIFSFGILLFNVVTGK-KFAPNFN-RSRHEAGGRREAFLSIPHLS AqueK496_Aque LFET--GQEIYSTKVDVFAYGMTLYEIISLQ-APFQKQE-AMKR---------------- AqueK497_Aque AIKRRGEDQAFDEKVDIFSFGMLLFELITGQ-RPFESMS------------------TGQ AqueK498_Aque ILMYYG-KEAYNEKVDIFSFAMLIYEMITFR-LPFEHLT-------------------PS LRRK2_Hsap ------------------EFDELEIQGKLPDPVKEYG-----CAPWPMVEKLIKQCLKEN LRRK1_Hsap ------------------QIAKKLSKGIRPV-LGQP-----EEVQFRRLQALMMECWDTK CG5483_Dmel ------------------SIKECILEGSRPA-LTQRE-----TQFPTCCLDLMVLCWHEQ LRRK2_Mmus ------------------EFDELAIQGKLPDPVKEYG-----CAPWPMVEKLITKCLKEN LRRK1_Mmus ------------------QIVKKLSKGIRPV-LGQP-----EEVQFHRLQALMMECWDTK T27C10.5_Cele ------------------HVKERMLDGARPV-LLPHE-----LLLPTPMLDLLVHCWSAH GbpC_Ddis ------------------KLEDEIIRGLRPT-IPPTC--------PPEYVELIQSCWTHE Pats1_Ddis ------------------LIEEKVINGERPK-IPEDC--------PEMYSKLIVECWQTD QkgA_Ddis ------------------FINLIREENLRPT-LPFD-------C-DPRLSNLIQLCWSTN QkgA_C2d_Ddis ------------------FINLIREENLRPT-LPFD-------C-DPRLSNLIQLCWSTN Roco10_Ddis -------------------FSNIVISGQRPS-IPLD-------C-LPSFADLIKDCWSGE Roco11_Ddis ------------------FIRKIREEDLRPT-IPSD-------C-PPTISNLIELCWSGD Roco4_Ddis ------------------FINMIREEGLRPT-IPED-------C-PPRLRNVIELCWSGD Roco5_Ddis ------------------QLEDEITNGLRPT-IPQNSV-----CGHPDFITLITDCWQND Roco6_Ddis ------------------LQEDAIKNGLRPT-ISPSYT---QTVTGHEYCGLIQDCWDSD Roco7_Ddis ------------------IIEDKIMKGLRPT-IPNE-------C-PPDMKQLITDCWSGD Roco8_Ddis ------------------TLEDNILSGLRPS-INQ--------NCNRMYSSLITKCWNAD Roco9_Ddis ------------------EVEGLITEGVRPS-LPSHN--------LPEYDSLLNICWAQD LRRKd_Spur ------------------EIELAVNEGRKPT-FNFHEYTMPPKQVFPALGALMESCWQNK LRRKc_Spur ------------------EIQLAVNEGRKPT-FNFHEYKMPPRQVFPALGALMESCWQDK LRRKb_Spur ------------------EIDEAVIKGQHLPPISQGG-----VAPWPDLQELIDHCTEHV LRRKa_Spur ------------------VIKQLIKDGQRPV-LSRKE-----KSYPTYMLDLLSWCWAQD AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------RFQTATGNADRPN-LKPL-----N-GLCPYFTPLLDKCWNND AqueK490_Aque -------------------------MAHKPK-LTGL-----STYGFGSLVKLMEECWEED AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------RIDTKVVQGDRPS-TVDMPI---AETGYFFLTRLMEKCWKDK AqueK493_Aque ------------------RIDTKVVQGDRPS-TVDMPI---AETGYFFLTRLMEKCWKDK AqueK494_Aque ------------------EKDKAVEEGRLIKD-PSYY----GGAPWPDMHDIIRHCLQYV AqueK495_Aque IIASAIEEQRLVGSSNQSPATLLLKDGVHPA-AREGHI---STCISTCMQVILEDCLSID AqueK496_Aque --------------------NAEVRAGKRPP-TGN--K---EKHTPLLLQDLMRLCWSKD AqueK497_Aque ------------------EVNRAVIQRERPQ-VSEGN----MEPSFPGMIELMEDCWRHL AqueK498_Aque ------------------QANQANENGARPT-LKRID-----LPCPVLIRELMVWCWQQS LRRK2_Hsap PQERPTSAQVF------------------------------------DI LRRK1_Hsap PEKRPLALSVVSQMK------------------------------DPTF CG5483_Dmel PRRRPTASQIV------------------------------------SI LRRK2_Mmus PQERPTSAQVF------------------------------------DI LRRK1_Mmus PEKRPLALSVVSQMK------------------------------DPTF T27C10.5_Cele PESRPSSSQLV------------------------------------GF GbpC_Ddis PNSRPTFTSIVEIL--------------------------------GQI Pats1_Ddis ASQRPKFSEIED-----------------------------------RL QkgA_Ddis PKKRPSFTFIIKEL---------------------------------LE QkgA_C2d_Ddis PKKRPSFTFIIKEL---------------------------------LE Roco10_Ddis PLNRPSPSKII-------------------------------------S Roco11_Ddis PKKRPHFSY---------------------------------------I Roco4_Ddis PKKRPHFSYIV-------------------------------------K Roco5_Ddis PLKRPTFID---------------------------------------I Roco6_Ddis IDRRPTFNKIVKRIK-------------------------------QII Roco7_Ddis PKKRPSFNSILERL--------------------------------STM Roco8_Ddis PNLRPSFNSILK-----------------------------------TL Roco9_Ddis PTCRPSFIEITKKLEEIELIL--KTHTPVEPVYTE-----TSKNQHIQL LRRKd_Spur PGERPHGETTLQLLS------------------------------EPSF LRRKc_Spur PGKRPHGKTILQLLS------------------------------EPSF LRRKb_Spur PESRPTAQEAFEK---------------------------------LSS LRRKa_Spur SRDRPSMEQIK------------------------------------DV AqueK485_Aque ------------------------------------------------L AqueK486_Aque -----------------------------------------------SK AqueK487_Aque ------------------------------------------------Y AqueK488_Aque ------------------------------------------------L AqueK489_Aque PHKRPYFIEILH-----------------------------------QF AqueK490_Aque PTLRPSALDLLH-----------------------------------LL AqueK491_Aque ------------------------------------------------N AqueK492_Aque ADDRPETSELISD---------------------------------VSK AqueK493_Aque ADDRPETSELISD---------------------------------VSK AqueK494_Aque PNNRPRAQDIFDRMCMPDF----------------------MALRHVVP AqueK495_Aque PIKRPTAEGVASR---------------------------------LVI AqueK496_Aque PSARPKMKECLQ-----------------------------------WT AqueK497_Aque AADRPTADEVVQR---------------------------------ISA AqueK498_Aque EELRPTASQITKVSQMDQF-LRLADAIRVNNFGSQVAGSCYRILKSPVF