CLUSTAL W (1.83) multiple sequence alignment TTN_Hsap YMI-AEDLGRGEFGIVHRCVETSSK-KTYMAKFVKVK-GTDQVLVKKEISILNIAR---- smMLCK_Hsap YDI-EERLGSGKFGQVFRLVEKKTR-KVWAGKFFKAYSAKEKENIRQEISIMNCLH---- skMLCK_Hsap MNS-KEALGGGKFGAVCTCMEKATG-LKLAAKVIKKQTPKDKEMVLLEIEVMNQLN---- SgK085_Hsap VSK-TEILGGGRFGQVHKCEETATG-LKLAAKIIKTRGMKDKEEVKNEISVMNQLD---- Strn-Mlck_Dmel FEI-IEELGKGRFGIVYKVQERGQPEQLLAAKVIKCIKSQDRQKVLEEISIMRALQ---- CG18020_Dmel YDI-GDELGRGTQGITYHAVERSSG-DNYAAKIMYGRP-ELRPFMLNELEMMNTFN---- bt_Dmel YDI-LEEIGTGAFGVVHRCRERSTG-NIFAAKFIPVSHSVEKDLIRREIDIMNQLH---- CG18021_Dmel YSF-ISEIARGEFSTIVKGIQKSTD-TVVVAKILEVTD-ENEDNVVAEFDNFKTLR---- CG1776_Dmel YDV-LGEVGRGKFGTVYKCRDKANG-LQLAAKFVPIPKREDKRNVEREVEIMNSLQ---- caMLCK_Mmus VSQ-HEVLGGGRFGQVHRCTERSTG-LALAAKIIKVKNVKDREDVKNEVNIMNQLS---- caMLCK_Hsap VCQ-HEVLGGGRFGQVHRCTEKSTG-LPLAAKIIKVKSAKDREDVKNEINIMNQLS---- SgK085_Mmus VSK-SEILGGGRFGQVHKCEEKATG-LKLAAKIIKTRGAKDKEDVKNEISVMNQLD---- skMLCK_Mmus MNS-KEALGGGKFGAVCTCTERATG-LKLAAKVIKKQTPKDKEMVLLEIEVMNQLN---- smMLCK_Mmus YDI-EERLGSGKFGQVFRLVEKKTG-KIWAGKFFKAYSAKEKDNIRQEISIMNCLH---- ZC373.4_Cele YQV-TKLLGDGKFGKVYCVIEKETG-KEFAAKFIKIRKEADRAEVEREVSILTQLR---- TTN_Spur YQI-LEELGRGSYGIVYRAIEKKTQ-KTWAAKFMRCFG-KERDLVRREIEVMKKLH---- MLCKa_Spur YQI-KEVLGKGRFGTVHKCIEKVTG-KAYAAKMIKTIKSTDKESVKNEIEIMNKLH---- MLCKb_Spur YEI-REELGRGKFGTVNKCIAKESK-KTWAAKFIKAEKPADKEEVEHEIEIMMILQ---- MLCKc_Spur YEL-LTELGRGAYGVVHKGISKADG-SECAVKTIRVKA-GMWEEVRNEIAVMGILD---- MLCKd_Spur YIV-KEELGKGKFGIVYRCEEKSTG-KTWAAKYVKTIRAKDKEAVQREIDLMSELE---- Projectin_Spur YHI-GEEIGRGPFGVVHRCIERGTG-RTFAAKFMDVE-PKDKAFIKEEIEAMNQLQ---- TTN_Mmus YMI-AEDLGRGEFGIVHRCVETSSK-RTFMAKFVKVK-GTDQVLVKKEISILNIAR---- ttn-1_Cele YII-HEELGKGAYGTVYRATEKATG-KTWAAKMVQVRPGVKKENVIHEISMMNQLH---- ttn-1~b_Cele ------------------------G-enbank---------------------------- unc-89_Cele FQI-GGLKFKGRFSVIRDAVDSTTE-G-HAHCAVKIRH-PSS-EAISEYESLRDGQ---- unc-89~b_Cele ------------------------------------------------------------ AqueK076_Aque YLL-KNEIAKGMFGTVYKCLHKGTQ-QIYAAKLIPINL--QINHCQNELDILALIC---- AqueK077_Aque YEI-INEIGRGSFSVVYECTELTTD-RPFAAKFIKCSNDDQFSVALREFEMIKNVT---- AqueK078_Aque YELLSGELGRGRFGIVRSCVSKVTG-SAAAAKYLKE-----SHDVLQEVKILRNLSSGPS TTN_Hsap -HRNILHLHESFES-MEE--LVMIFEFISGLDIFERINTSAF------------------ smMLCK_Hsap -HPKLVQCVDAFEE-KAN--IVMVLEIVSGGELFERIIDEDF------------------ skMLCK_Hsap -HRNLIQLYAAIET-PHE--IVLFMEYIEGGELFERIVDEDY------------------ SgK085_Hsap -HANLIQLYDAFES-KND--IVLVMEYVDGGELFDRIIDESY------------------ Strn-Mlck_Dmel -HPKLLQLAASFES-PRE--IVMVMEYITGGELFERVVADDF------------------ CG18020_Dmel -HKNLIRPYDAYDT-DRS--VTLIMELAAGGELVRDNLLRRD------------------ bt_Dmel -HQKLINLHDAFED-DDE--MILILEFLSGGELFERITAEGY------------------ CG18021_Dmel -HERIPALFSAYKP-LNVPIAIFVMEKLQGADVLTYFSSRH------------------- CG1776_Dmel -HHLIIQLYAAYEY-QKM--MCVVLELIEGGELFDRVVDDEF------------------ caMLCK_Mmus -HVNLIQLYDAFES-KSS--FTLIMEYVDGGELFDRITDEKY------------------ caMLCK_Hsap -HVNLIQLYDAFES-KHS--CTLVMEYVDGGELFDRITDEKY------------------ SgK085_Mmus -HVNLIQLYDAFES-KHD--IILVMEYVEGGELFDRIIDENC------------------ skMLCK_Mmus -HRNLIQLYAAIET-SHE--IILFMEYIEGGELFERIVDEDY------------------ smMLCK_Mmus -HPKLVQCVDAFEE-KAN--IVMVLEIVSGGELFERIIDEDF------------------ ZC373.4_Cele -HPRIAQIYDAFYTTTND--VVLIMEIVRGGELFDRVAEESY------------------ TTN_Spur -HRRLLNLHEVFET-NEE--IIMILEFLSGGELFDRLVDENH------------------ MLCKa_Spur -HAKLLQCLDAFES-PKQ--MIMVLEIVNGGELFERVIDDDF------------------ MLCKb_Spur -HPKLLQLYDAFAT-GSN--MVMILEYVSGGELFDRVVDEEF------------------ MLCKc_Spur -HKRLIKLFDAYET-KRE--VVMAMEILTGGELFERIVQRDSFSESEAVGFLKQLIDGLI MLCKd_Spur -HPSLMALIEAYQS-SRQ--TVMILECITGGELFERIVDDTF------------------ Projectin_Spur -HPRLQQCHDAFDM-DDK--FVLITDFISGGDAFQRAKE-RG------------------ TTN_Mmus -HRNILYLHESFES-MEE--LVMIFEFISGLDIFERINTSAF------------------ ttn-1_Cele -HEKLLNLHEAFDM-GNE--MWLIEEFVSGGELFEKILEDDS------------------ ttn-1~b_Cele ------------------------------------------------------------ unc-89_Cele -HENVQRLIAAFNN-SNF--LYLLSERLY-EDVFSRFVFND------------------- unc-89~b_Cele ------------------------------------------------------------ AqueK076_Aque -HPNIVQLSAAYLS-HQH--FIIVMQYIQGLSPLTYFNER-------------------- AqueK077_Aque -HPRIASLEDAFRS-ENH--VILVLQYVPGGDLFNYITSSG------------------- AqueK078_Aque PSPHVILFIDALIT-DEN--IVIITEVADGGQLIDYILRMYN------------------ TTN_Hsap ------------------------------------------------------------ smMLCK_Hsap ------------------------------------------------------------ skMLCK_Hsap ------------------------------------------------------------ SgK085_Hsap ------------------------------------------------------------ Strn-Mlck_Dmel ------------------------------------------------------------ CG18020_Dmel ------------------------------------------------------------ bt_Dmel ------------------------------------------------------------ CG18021_Dmel ------------------------------------------------------------ CG1776_Dmel ------------------------------------------------------------ caMLCK_Mmus ------------------------------------------------------------ caMLCK_Hsap ------------------------------------------------------------ SgK085_Mmus ------------------------------------------------------------ skMLCK_Mmus ------------------------------------------------------------ smMLCK_Mmus ------------------------------------------------------------ ZC373.4_Cele ------------------------------------------------------------ TTN_Spur ------------------------------------------------------------ MLCKa_Spur ------------------------------------------------------------ MLCKb_Spur ------------------------------------------------------------ MLCKc_Spur YMHDRNVVHLDLKPENILLVAPESDDIKLIDFGLAAVLKEGEDITCKFGTPEFVAPEVVN MLCKd_Spur ------------------------------------------------------------ Projectin_Spur ------------------------------------------------------------ TTN_Mmus ------------------------------------------------------------ ttn-1_Cele ------------------------------------------------------------ ttn-1~b_Cele ------------------------------------------------------------ unc-89_Cele ------------------------------------------------------------ unc-89~b_Cele ------------------------------------------------------------ AqueK076_Aque ------------------------------------------------------------ AqueK077_Aque ------------------------------------------------------------ AqueK078_Aque ------------------------------------------------------------ TTN_Hsap ----------------------------------ELNEREIVSYVHQVCEALQFLHSHNI smMLCK_Hsap ----------------------------------ELTERECIKYMRQISEGVEYIHKQGI skMLCK_Hsap ----------------------------------HLTEVDTMVFVRQICDGILFMHKMRV SgK085_Hsap ----------------------------------NLTELDTILFMKQICEGIRHMHQMYI Strn-Mlck_Dmel ----------------------------------TLTEMDCILFLRQVCDGVAYMHGQSV CG18020_Dmel ----------------------------------YYTERDIAHYIRQTLWGLEHMHEMGV bt_Dmel ----------------------------------VMTEAEVINYMRQICEGIRHMHEQNI CG18021_Dmel ----------------------------------EYSEQMVATVVTQLLDALQYLHWRGY CG1776_Dmel ----------------------------------VLTERVCRVFIRQVCEAMAFIHGNGI caMLCK_Mmus ----------------------------------HLTELDVVLFTRQICEGVHYLHQHYI caMLCK_Hsap ----------------------------------HLTELDVVLFTRQICEGVHYLHQHYI SgK085_Mmus ----------------------------------NLTELDTILFMKQICEGIRYMHQMYI skMLCK_Mmus ----------------------------------HLTEVDTMVFVRQICDGILFMHKMRV smMLCK_Mmus ----------------------------------ELTERECIKYMRQISEGVEYIHKQGI ZC373.4_Cele ----------------------------------VLSELAVVMIICQLCEAIDYIHKQNI TTN_Spur ----------------------------------ILTEPEVIFYMKQTCEGVKHMHERHL MLCKa_Spur ----------------------------------GLTESDVIEFMRQICAGVHHMHSTNI MLCKb_Spur ----------------------------------ELTEAVVVFLMRQICEGVKFMHEKGV MLCKc_Spur KQPVSTGADVWGVGVIAFILLTGGELFERIVQRDSFSESEAVGFLKQLIDGLIYMHDRNV MLCKd_Spur ----------------------------------DLTESEVISYMRQICAGVQHMHHHNI Projectin_Spur ----------------------------------TLSEEVVARYTRQVCEGLLHIHLQNH TTN_Mmus ----------------------------------ELNEREIVSYVRQVCEALEFLHSQNI ttn-1_Cele ----------------------------------LMSEEEVRDYMHQILLGVSHMHKNQI ttn-1~b_Cele ------------------------------------------------------------ unc-89_Cele ----------------------------------YYTEEQVALTMRQVTSALHFLHFKGI unc-89~b_Cele -------------------------------------------FVRQLLLALKHMHDLRI AqueK076_Aque ----------------------------------NSSEHDIAKFCRELCCGLKHLHDHGI AqueK077_Aque ----------------------------------PIDERQ---------------SARNI AqueK078_Aque ----------------------------------SLNELLIVEYVKQLLSALDYIHERQI TTN_Hsap GHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDN---FRLLFTAPEYYAPEVHQHDVV smMLCK_Hsap VHLDLKPENIMCVNKTGTRIKLIDFGLARRLENAGS---LKVLFGTPEFVAPEVINYEPI skMLCK_Hsap LHLDLKPENILCVNTTGHLVKIIDFGLARRYNPNEK---LKVNFGTPEFLSPEVVNYDQI SgK085_Hsap LHLDLKPENILCVNRDAKQIKIIDFGLARRYKPREK---LKVNFGTPEFLAPEVVNYDFV Strn-Mlck_Dmel VHLDLKPENIMCHTRTSHQIKIIDFGLAQRLDTKAP---VRVLFGTPEFIPPEIISYEPI CG18020_Dmel GHMGLTIKDLLISVVGGDIIKVSDFGLSRKINRHNL---STLDYGMPEFVSPEVVNKEGV bt_Dmel IHLDIKPENIMCQTRSSTNVKLIDFGLATRLDPNEV---VKITTGTAEFAAPEIVNREPV CG18021_Dmel CHLNIQPDNVVMASVRSIQVKLVDFGSAKKVNKLGM---KVTPCGSLDFQPPEMINDEPI CG1776_Dmel VHLDLKPENILVLTQKGNRIKIIDFGLARKFDPDKR---LRVLFGTPEFVAPEVVNFDCI caMLCK_Mmus LHLDLKPENILCVSQTGHQIKIIDFGLARRYKPREK---LKVNFGTPEFLAPEVVNYEFV caMLCK_Hsap LHLDLKPENILCVNQTGHQIKIIDFGLARRYKPREK---LKVNFGTPEFLAPEVVNYEFV SgK085_Mmus LHLDLKPENILCVNRDAKQIKIIDFGLARRYKPREK---LKVNFGTPEFLAPEVVNYDFV skMLCK_Mmus LHLDLKPENILCVNTTGHLVKIIDFGLARRYNPNEK---LKVNFGTPEFLSPEVVNYDQI smMLCK_Mmus VHLDLKPENIMCVNKTGTRIKLIDFGLARRLENAGS---LKVLFGTPEFVAPEVINYEPI ZC373.4_Cele LHLDVKPENIMCVSLTGNRIKLIDFGLARHYDGTQE---LKYMAGTPEFAAPEVIKFEKL TTN_Spur VHLDLKPENIMLCARNSDDIKIIDFGLTMELDPDKP---VKIMFGTPDFIAPEVVNHEPI MLCKa_Spur LHLDLKPENILCIDKTGSRIKLIDFGLARDFNPAQS---TKVMFGTPEFVAPEVINYDVI MLCKb_Spur LHLDMKPENILCVRKNSNKIKIIDFGLAQKYTK--N---LQVSCGTPEFLAPEVVSYDDV MLCKc_Spur VHLDLKPENILLVAPESDDIKLIDFGLAAVLKEGED---ITCKFGTPEFVAPEVVNKQPV MLCKd_Spur MHLDLKPENIMCVNRTGFQLKIIDFGLARKYEPDSD---VKVLCGTPEFVAPEVISYDAI Projectin_Spur MHLALRPQSILFQTKRSDSVKIIDFGLAAKLDPDER---VKIAYAEPDYASPEVLNGDQL TTN_Mmus GHFDIRPENIIYQTRKNSTIKIIEFGQARQLKPGDN---FRLLFTAPEYYAPEVHQHDVV ttn-1_Cele VHLDLKPENILLKAKNSNELKIIDFGLARKLDPKKS---VKLLFGTPEFCAPEVVNYQPV ttn-1~b_Cele ------------------------------------------------------------ unc-89_Cele AHLDVNPHNIMFQSKRSWVVKLVDFGRAQKVSGAVKPVDFDTKWASPEFHIPE----TPV unc-89~b_Cele AHLDLRPETILLQD---DKLKLADFGQARRLLRGLI---TGEIKGSPEFVSPEIVRSYPL AqueK076_Aque VHLAIKPDSVYVVPNS-------------------------------------------- AqueK077_Aque LLINIAPENLVLG-VGLQEVKIIDFSHSKYLHSNPQ---LEILPQQINYLSPEALQCSPL AqueK078_Aque VHLDVKPENLLIASEVAPILKLTDFGSAQEV-PYAG---LSVRPDLIEFSSPEVVFDDNV TTN_Hsap STATDMWSLGTLVYVLLSGINPFLAETNQQ--IIENIMNAEYTFDE-EAFKEISIEAMDF smMLCK_Hsap GYATDMWSIGVICYILVSGLSPFMGDNDNE--TLANVTSATWDFDD-EAFDEISDDAKDF skMLCK_Hsap SDKTDMWSMGVITYMLLSGLSPFLGDDDTE--TLNNVLSGNWYFDE-ETFEAVSDEAKDF SgK085_Hsap SFPTDMWSVGVIAYMLLSGLSPFLGDNDAE--TLNNILACRWDLED-EEFQDISEEAKEF Strn-Mlck_Dmel GFQSDMWSVGVICYVLLSGLSPFMGDTDVE--TFSNITRADYDYDD-EAFDCVSQEAKDF CG18020_Dmel NFSHDMWTVGLITYVLLGGHNPFLGIDDRE--TLTKIREGRWDFKD-EIWTHISDDGRDF bt_Dmel GFYTDMWATGVLSYVLLSGLSPFAGDNDVQ--TLKNVKACDWDFDV-ESFKYISEEAKDF CG18021_Dmel FPQSDIWSLGALTYLLLSGCSPFRGADEYE--TKQNISFVRYRFE-N-LFKEVTPEATRF CG1776_Dmel SYGTDMWSVGVICYVLISGLSPFMGENDIE--TMSNVTIAKYDFED-ECFNGISPECLDF caMLCK_Mmus SFPTDMWSVGVITYMLLSGLSPFLGETDAE--TMNFIVNCSWDFDA-DTFKGLSEEAKDF caMLCK_Hsap SFPTDMWSVGVITYMLLSGLSPFLGETDAE--TMNFIVNCSWDFDA-DTFEGLSEEAKDF SgK085_Mmus SFSTDMWSVGVITYMLLSGLSPFLGDNDAE--TLTNILACRWDLED-EEFQDISEEAKEF skMLCK_Mmus SDKTDMWSLGVITYMLLSGLSPFLGDDDTE--TLNNVLSANWYFDE-ETFEAVSDEAKDF smMLCK_Mmus GYATDMWSIGVICYILVSGLSPFMGDNDNE--TLANVTSATWDFDD-EAFDEISDDAKDF ZC373.4_Cele DYHTDMWSIGVITYILLSGYSPFLGDNLGE--TYCNVEKGVWEFTE--EFDTVTEEAKDF TTN_Spur GLPTDMWALGVIAYLMLSGISPFEGETDRE--TLKNVATGEWDFDE-EAFADISDEGLDW MLCKa_Spur GFTTDMWSVGVICYILLSGLSPFMGDNDAE--TLNNVTLAEWDFED-EAFDAISEDAKTF MLCKb_Spur AYGTDMWSVGVICYILLSGFSPFMGDNEGE--TMSNILKLEWDFED-ECFDEISDLAKQF MLCKc_Spur STGADVWGVGVIAFILLSGISPFAGEDDRQ--TLLNVRGGQWDFDD-EVWDDISDEAQDF MLCKd_Spur TPLTDMWSVGVICYVLLSGLSPFLGDSDSE--TLNNVTMGEWDFED-EAFDGISNCAKDF Projectin_Spur GFSTDMWSIGLIVYMLLSGLHPFENDAD-------RIKSCKWSFDK-SAFREISPEAQDF TTN_Mmus STATDMWSLGTLVYVLLSGINPFLAETNQQ--MIENIMNAEYTFDE-EAFKEISLEAMDF ttn-1_Cele GLSTDMWTVGVISYVLLSGLSPFLGDSDED--TLANVSASDWDFDD-PSWDDVSDLAKDF ttn-1~b_Cele ------------------------------------------------------------ unc-89_Cele TVQSDMWGMGVVTFCLLAGFHPFTSEYDREEEIKENVINVKCDPN-L-IPVNASQECLSF unc-89~b_Cele TLATDMWSTGVLTYVLLTGLSPFHGDNDNE--TLANVDSCQ--FDS-SPLGNFSYDAGDF AqueK076_Aque ---------------------------------------------------------FDF AqueK077_Aque ALSTDLWSVGAVALFMLSGQCPFVSDTRDQ--LINNIHTLNINYKINPIIQRLSLDCTNM AqueK078_Aque TKCTDLWSTGVITYLLLSGVSPFFHEYPSV--SSQRLSRAQYDLSL-QLFHSTSPQAIDF TTN_Hsap V-DRLLVKERKSRMTASEALQHPWL smMLCK_Hsap I-SNLLKKDMKNRLDCTQCLQHPWL skMLCK_Hsap V-SNLIVKDQRARMNAAQCLAHPWL SgK085_Hsap I-SKLLIKEKSWRISASEALKHPWL Strn-Mlck_Dmel I-SQLLVHRKEDRLTAQQCLASKWL CG18020_Dmel I-SRLLLYSPEERMDVKTALKHPWF bt_Dmel I-RKLLVRNKEKRMTAHECLLHPWL CG18021_Dmel I-MLLFKRHPTKRPYTEDCLEHRWL CG1776_Dmel I-AKLLAKDLSTRMTAAECMKHKWL caMLCK_Mmus V-SRLLVKEKSCRMSATQCLKHEWL caMLCK_Hsap V-SRLLVKEKSCRMSATQCLKHEWL SgK085_Mmus I-SKLLIKEKSWRISASEALKHPWL skMLCK_Mmus V-SNLLTKDQSARMSAEQCLAHPWL smMLCK_Mmus I-SNLLKKDMKNRLDCTQCLQHPWL ZC373.4_Cele V-TKLLVYDQSKRMLPHECLQHPWI TTN_Spur I-ERILIKGKEGRMTIQEALDHPWL MLCKa_Spur I-EGLLIQKKEERMTAAECLQHHWL MLCKb_Spur I-ENLLVEEKNDRLTCPQCLESEWL MLCKc_Spur I-WLLFEMNADKRPGLKEVSEHPWL MLCKd_Spur I-SDLLVK----------------D Projectin_Spur I-SRLLIKDKSERMAAHEALDHPWS TTN_Mmus V-DRLLVKERKSRMTASEALQHPWL ttn-1_Cele I-CRLMIKDKRKRMSVQDALRHPWI ttn-1~b_Cele ------------------girefNP unc-89_Cele A-TWALKKSPVRRMRTDEALSHKFL unc-89~b_Cele V-KKLLTEIPVSRLTVDEALDHPWI AqueK076_Aque TV--------------------KLI AqueK077_Aque IFDGLLLTNESKRLSSHQCQRHRWL AqueK078_Aque I-SALLKKQPAERLTAASALEHQWI