CLUSTAL W (1.83) multiple sequence alignment PDGFRb_Hsap LVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLG PDGFRa_Hsap LVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLG KIT_Hsap LSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLG FMS_Hsap LQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLG FLT3_Hsap LEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLG PDGFRb_Mmus LVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLG PDGFRa_Mmus LVLGRILGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLG KIT_Mmus LSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLG FMS_Mmus LQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLG FLT3_Mmus LEFGKVLGSGAFGRVMNATAYGISKTGVSIQVAVKMLKEKADSCEKEALMSELKMMTHLG * :*: **:****:*::.**.*: : : ******* .* *::*******::: ** PDGFRb_Hsap PHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHS---DKRRPPSAELY PDGFRa_Hsap PHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHP---EKP--KKELDI KIT_Hsap NHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQ---EDHAE--AALY FMS_Hsap QHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEG--GVDY FLT3_Hsap SHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWT---EIFKEHNFSFY PDGFRb_Mmus PHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQRHS---NKHCPPSAELY PDGFRa_Mmus PHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFMSQHP---EKP--KKDLDI KIT_Mmus NHMNIVNLLGACTVGGPTLVITEYCCYGDLLNFLRRKRDSFIFSKQ---EEQAE--AALY FMS_Mmus QHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDSEG--DSSY FLT3_Mmus HHDNIVNLLGACTLSGPVYLIFEYCCYGDLLNYLRSKREKFHRTWT---EIFKEHNFSFY * *:******** .** :* *** ****:::*: : . : : PDGFRb_Hsap SNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYD PDGFRa_Hsap FGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPAS KIT_Hsap KNLLHSKESS------CSDSTNEYMDMKPGVS-YVVPT---K------------ADKRRS FMS_Hsap KNIHLEKKYVRRDSGFSSQGVDTYVEMRPV-----------------------------S FLT3_Hsap PTFQSHPNSS-------MPGS-REVQIHPDSD-QISGL---H---------------GNS PDGFRb_Mmus SNALPVGFSLPSHLNLTGESDGGYMDMSKDESIDYVPMLDMKGDIKYADIESPSYMAPYD PDGFRa_Mmus FGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPAS KIT_Mmus KNLLHSTEPS-------CDSSNEYMDMKPGVS-YVVPT---K------------TDKRRS FMS_Mmus KNIHLEKKYVRRDSGFSSQGVDTYVEMRPV-----------------------------S FLT3_Mmus PTFQAHSNSS-------MPGS-REVQLHPPLD-QLSGF---N---------------GNL . ::: PDGFRb_Hsap NYVPSAPERTCRATL---I-NESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNV PDGFRa_Hsap YKKKSMLDSEVKNLL---SDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNV KIT_Hsap VRIGSYIERDVTPAI---MEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNI FMS_Hsap T---SSNDSFSEQDL---DKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNV FLT3_Hsap FHSEDEIEYENQKRLE--EEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNV PDGFRb_Mmus NYVPSAPERTYRATL---I-NDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNV PDGFRa_Mmus YKKKSMLDSEVKNLL---SDDDSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNV KIT_Mmus ARIDSYIERDVTPAI---MEDDELALDLDDLLSFSYQVAKGMAFLASKNCIHRDLAARNI FMS_Mmus T---SSSDSFFKQDL---DKEASRPLELWDLLHFSSQVAQGMAFLASKNCIHRDVAARNV FLT3_Mmus IHSEDEIEYENQKRLAEEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNV . : : : * **: *: ***.** ** *.*:***:****: PDGFRb_Hsap LICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGIL PDGFRa_Hsap LLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGIL KIT_Hsap LLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIF FMS_Hsap LLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGIL FLT3_Hsap LVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGIL PDGFRb_Mmus LICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGIL PDGFRa_Mmus LLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGIL KIT_Mmus LLTHGRITKICDFGLARDIRNDSNYVVKGNARLPVKWMAPESIFSCVYTFESDVWSYGIF FMS_Mmus LLTSGHVAKIGDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGIL FLT3_Mmus LVTHGKVVKICDFGLARDILSDSSYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGIL *: *::.** ******** **.*: :*.: **:*******:*. :** *****:**: PDGFRb_Hsap LWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFS PDGFRa_Hsap LWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFY KIT_Hsap LWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFK FMS_Hsap LWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQ FLT3_Hsap LWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFP PDGFRb_Mmus LWEIFTLGGTPYPELPMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFS PDGFRa_Mmus LWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVQCWNSEPEKRPSFY KIT_Mmus LWELFSLGSSPYPGMPVDSKFYKMIKEGFRMVSPEHAPAEMYDVMKTCWDADPLKRPTFK FMS_Mmus LWEIFSLGLNPYPGILVNNKFYKLVKDGYQMAQPVFAPKNIYSIMQSCWDLEPTRRPTFQ FLT3_Mmus LWEIFSLGVNPYPGIPVDANFYKLIQSGFKMEQPFYATEGIYFVMQSCWAFDSRKRPSFP ***:*:** .*** : :: **: :: *::* .* .*. :* :* ** . **.* PDGFRb_Hsap -----Q PDGFRa_Hsap HLSEIV KIT_Hsap QIVQLI FMS_Hsap QICSFL FLT3_Hsap NLTSFL PDGFRb_Mmus -----Q PDGFRa_Mmus HLSEIV KIT_Mmus QVVQLI FMS_Mmus QICFLL FLT3_Mmus NLTSFL