CLUSTAL W (1.83) multiple sequence alignment TRRAP_Hsap_TRRAP IA----------RFM-PRVEIVQKHNTAARRLYIRGHNGK-------------------- SMG1_Hsap_SMG1 ------------------ITILPT-KTKPKKLLFLGSDGK-------------------- FRAP_Hsap_FRAP II-------RIQSIA-PSLQVITS-KQRPRKLTLMGSNGH-------------------- mei-41_Dmel_ATR Li---------------------------------------------------------- CG2905_Dmel_TRRAP Li---------------------------------------------------------- CG6535_Dmel_ATM Li---------------------------------------------------------- CG4549_Dmel_SMG1 Li---------------------------------------------------------- FRAP_Mmus_FRAP II-------RIQSIA-PSLQVITS-KQRPRKLTLMGSNGH-------------------- DNAPK_Mmus_DNAPK HV-------RISGFD-ERVKVMLS-LRKPKRIVIRGHDEK-------------------- ATR_Mmus_ATR AY--------LAGFD-DVVEILSS-LQKPKKISLKGSDGK-------------------- ATM_Mmus_ATM ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR AY--------IAGFD-DMVEILAS-LQKPKKISLKGSDGK-------------------- DNAPK_Hsap_DNAPK HV-------RIAGFD-ERVTVMAS-LRRPKRIIIRGHDER-------------------- TOR_Dmel_FRAP Li---------------------------------------------------------- SMG1_Mmus_SMG1 ------------------ITILPT-KTKPKKLLFLGSDGK-------------------- TRRAP_Mmus_TRRAP IA----------RFM-PRVEIVQKHNTAARRLHIRGHNGK-------------------- ATR_Ddis_ATR At---------------------------------------------------------- DNAPK_Ddis_DNAPK At---------------------------------------------------------- SMG1_Ddis_SMG1 At---------------------------------------------------------- Tor_Ddis_FRAP At---------------------------------------------------------- TRRAP_Ddis_TRRAP At---------------------------------------------------------- CC1G_00839_Ccin_ATM I----------HKYE-NVFETAGG-VNCPKISWCYGTDGV-------------------- CC1G_08126_Ccin_ATR T---------FKEFS-DEIDVMRS-MARPRKIWITGSDGG-------------------- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K LPLPLNAKIEVTGIIPEKSSVFKS-NLYPLLLYFQCSDGS-------------------- CC1G_04234_Ccin_PI4K RI----------M------KEMISL-EEERMARMQEGDGAFVTVPQMSETSGSSKTLEDE CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP QE-------L------------ML-ESAWRTLEWAGHKE--------------------- GK008_Glam_FRAP IT-------TIVKFY-QKVFVIRS-KQRPRKVGLVASDGE-------------------- GK009_Glam_PIKK-Unclassified G----------------------------------------------------------- TRRAP_Hsap_TRRAP --------------------------------------------IYPYLVMNDACLTESR SMG1_Hsap_SMG1 --------------------------------------------SYPYLFKGL---EDLH FRAP_Hsap_FRAP --------------------------------------------EFVFLLKGH---EDLR mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP --------------------------------------------EFVFLLKGH---EDLR DNAPK_Mmus_DNAPK --------------------------------------------EYPFLVKGG---EDLR ATR_Mmus_ATR --------------------------------------------FYIMMCKPK---DDLR ATM_Mmus_ATM ----------------------------------------------RQLVKGR---DDLR ATM_Hsap_ATM ----------------------------------------------RQLVKGR---DDLR ATR_Hsap_ATR --------------------------------------------FYIMMCKPK---DDLR DNAPK_Hsap_DNAPK --------------------------------------------EHPFLVKGG---EDLR TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 --------------------------------------------SYPYLFKGL---EDLH TRRAP_Mmus_TRRAP --------------------------------------------IYPYLVMNDACLTESR ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM --------------------------------------------RYKQLFKGN---DDMR CC1G_08126_Ccin_ATR --------------------------------------------EYIMLIKPK---DDLR CC1G_00894_Ccin_FRAP --------------------------------------------DYQYVLKGH---EDLR CC1G_06302_Ccin_PI3K --------------------------------------------EYPVIFKDG---DDMR CC1G_04234_Ccin_PI4K SIIRKELNKVDPSAVVFSESWAAKKSRIRQSSPYGHLASLAQWDCMSVIVKTG---GDLR CC1G_13883_Ccin_PI4K --------------------------------------------WQQAIFKVG---DDCR CC1G_00331_Ccin_TRRAP -----------------------------------------------------------E GK008_Glam_FRAP --------------------------------------------YYAFLLKGH---EDLR GK009_Glam_PIKK-Unclassified ---------------------------------------------TRLILKCG---EDTV TRRAP_Hsap_TRRAP REERVLQLLRLLN----------PCLEKRKETTKRHL------------FFTVPRVVAVS SMG1_Hsap_SMG1 LDERIMQFLSIVN----------TMFATINRQETPRF------------HARHYSVTPLG FRAP_Hsap_FRAP QDERVMQLFGLVN----------TLLANDPTSLRKNL------------SIQRYAVIPLS mei-41_Dmel_ATR ---------------------------------------------------------pi- CG2905_Dmel_TRRAP ---------------------------------------------------------pi- CG6535_Dmel_ATM ---------------------------------------------------------pi- CG4549_Dmel_SMG1 ---------------------------------------------------------pi- FRAP_Mmus_FRAP QDERVMQLFGLVN----------TLLANDPTSLRKNL------------SIQRYAVIPLS DNAPK_Mmus_DNAPK QDQRIEQIFEVMN----------AILSQDAACSQRNM------------QLRTYRVVPMT ATR_Mmus_ATR KDCRLMEFNSLIN----------KSLRKDAESRRREL------------HIRTYAVIPLN ATM_Mmus_ATM QDAVMQQVFQMCN----------TLLQRNTETRKRKL------------TICTYKVVPLS ATM_Hsap_ATM QDAVMQQVFQMCN----------TLLQRNTETRKRKL------------TICTYKVVPLS ATR_Hsap_ATR KDCRLMEFNSLIN----------KCLRKDAESRRREL------------HIRTYAVIPLN DNAPK_Hsap_DNAPK QDQRVEQLFQVMN----------GILAQDSACSQRAL------------QLRTYSVVPMT TOR_Dmel_FRAP ---------------------------------------------------------pi- SMG1_Mmus_SMG1 LDERIMQFLSIVN----------TMFATINRQETPRF------------HARHYSVTPLG TRRAP_Mmus_TRRAP REERVLQLLRLLN----------PCLEKRKETTKRHL------------FFTVPRVVAVS ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM QDAVMEQVFELVN----------RILVKDRETSRRSL------------RVRSYKVVPLG CC1G_08126_Ccin_ATR KDARLMDFDTIIN----------RLLKANADARRRKL------------YIRTYAVVPLN CC1G_00894_Ccin_FRAP QDERVMQLFSLVN----------TLLSVDTNSFKRRL------------HIQRYPVIPLA CC1G_06302_Ccin_PI3K QDQLVIQLFTLMD----------QLLRKEN----LDL------------KLSPYDVLATG CC1G_04234_Ccin_PI4K QEQLAVQLIREFQ----------SIWAE----EKCAC------------WVKHFRILITG CC1G_13883_Ccin_PI4K QDVLALQVIAMFK----------NIFE----SIGLTL------------YLFPYRVTATA CC1G_00331_Ccin_TRRAP LDEQIAQLPDVATPRRRVFEAFIALLKQ-PAAIDKNVDFTRFLEDAMQLSLRKWVGLPQH GK008_Glam_FRAP QDERVMQLFTLIN----------NLLMNDSYCSRRGL------------MVMKYPITPLS GK009_Glam_PIKK-Unclassified ADYAVMQFTEELA----------KCSVN---TFFKPY------------FVAVLINIPKN TRRAP_Hsap_TRRAP PQMRLVEDNPS-SLSLVEIYKQR----CAK-KGIEH----D-NPISR----YYDRLATVQ SMG1_Hsap_SMG1 TRSGLIQWVDG-ATPLFGLYKRW----QQR-EAAL-----Q-AQKAQDSY------QT-- FRAP_Hsap_FRAP TNSGLIGWVPH-CDTLHALIRDY----REK-KKILL----N-IEHRIMLR------MA-- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP TNSGLIGWVPH-CDTLHALIRDY----REK-KKILL----N-IEHRIMLR------MA-- DNAPK_Mmus_DNAPK SRLGLIEWIEN-TMTLKDLLLSN----MSQEEKVAN----N-SDPKAPIRDYKDWLMKVS ATR_Mmus_ATR DECGIIEWVNN-TAGLRPILTKI----YKE-KGVYM----TGKELR--QC------ML-- ATM_Mmus_ATM QRSGVLEWCTG-TVPIGEYLVNS----EDGAHRRYRPNDFSANQCQK-KM------ME-- ATM_Hsap_ATM QRSGVLEWCTG-TVPIGEFLVNN----EDGAHKRYRPNDFSAFQCQK-KM------ME-- ATR_Hsap_ATR DECGIIEWVNN-TAGLRPILTKL----YKE-KGVYM----TGKELR--QC------ML-- DNAPK_Hsap_DNAPK SRLGLIEWLEN-TVTLKDLLLNT----MSQEEKAAY----L-SDPRAPPCEYKDWLTKMS TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 TRSGLIQWVDG-ATPLFGLYKRW----QQR-EAAL-----Q-AQKAQDSY------QT-- TRRAP_Mmus_TRRAP PQMRLVEDNPS-SLSLVEIYKQR----CAK-KGIEH----D-NPISR----YYDRLATVQ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM KQAGVLEFVSN-TSPLRNWLEAG----H----PIYRPGDISPKEARS-KL------YA-- CC1G_08126_Ccin_ATR EECGCIEWVQN-TSPLRPILFKY----YEA-RRIKT----WTAELEA-QC------NK-- CC1G_00894_Ccin_FRAP PNAGLLGWVQD-SDTLHVLIRDY----RES-RKVLL----N-IEYRLMLQ------MA-- CC1G_06302_Ccin_PI3K PLQGMVQFIPS-KT-IAAIVSEH----G--NV--------------L-NY------LR-- CC1G_04234_Ccin_PI4K STSGLIETIKD-AVSIHSIKKAE----YAK-RI-------A-EGR--------------- CC1G_13883_Ccin_PI4K PGCGVIDVVPN-ATSRDEMGRAK----V-------------------------------- CC1G_00331_Ccin_TRRAP FSVAHI--------PLLQHFQQF----VEL-QEAVQ-IFGSLSQTNAQ-N------LE-- GK008_Glam_FRAP QNSGLLYWVPG-CDTIISLIKEF----RQL-KRIHL----E-TEMQQIKY------RA-- GK009_Glam_PIKK-Unclassified -QVSIIEHIDGNVVPIDELLTPVFMGAKTK-AA-EF----I-NEQEP----NEDG----- TRRAP_Hsap_TRRAP ARGTQ----A--------------------------------SHQVL---RDILKEVQSN SMG1_Hsap_SMG1 ---------PQNPGIVPRPSELYYSKIGPALKTVGLSLDVSRRDWPLHVMKAVLEELMEA FRAP_Hsap_FRAP ---------PDY------------------------------DHLTLMQKVEVFEHAVNN mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ---------PDY------------------------------DHLTLMQKVEVFEHAVNN DNAPK_Mmus_DNAPK GKSDAGAYVLMY------------------------------SRANRTETVVAFRRRESQ ATR_Mmus_ATR ---------PK--------------------------------SAALSEKLKVFQELLLP ATM_Mmus_ATM ---------VQ--------------------------------KKSFEEKYDTFMTICQ- ATM_Hsap_ATM ---------VQ--------------------------------KKSFEEKYEVFMDVCQ- ATR_Hsap_ATR ---------PK--------------------------------SAALSEKLKVFREFLLP DNAPK_Hsap_DNAPK GKHDVGAYMLMY------------------------------KGANRTETVTSFRKRESK TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ---------PQNPsIVPRPSELYYSKIGPALKTVGLSLDVSRRDWPLHVMKAVLEELMEA TRRAP_Mmus_TRRAP ARGTQ----A--------------------------------SHQVL---RDILKEVQSN ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ---------AS--------------------------------SRSEEDRIKAYNEVCA- CC1G_08126_Ccin_ATR ---------IK--------------------------------DAQAADAGNIFVKKILP CC1G_00894_Ccin_FRAP ---------PDY------------------------------ENLMLLQKVEVFEYALEN CC1G_06302_Ccin_PI3K ---------VN--------------------------------NPD-EGSV--------- CC1G_04234_Ccin_PI4K ---------------------------------------------------------LGH CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ---------K--------------------------------KSSEL---KMVLQAWRER GK008_Glam_FRAP ---------PAF------------------------------MNMALHYKVDAFKYMLTT GK009_Glam_PIKK-Unclassified ---C---------------------------------------F-------PTFDLFMAS TRRAP_Hsap_TRRAP MVPRSMLKE-WALHTF--PNATDYW----TFRKMFTIQLALIG-------------FAEF SMG1_Hsap_SMG1 TPPN-LLAK-ELWSSC--TTPDEWW----RVTQSYARSTAVMS-------------MVGY FRAP_Hsap_FRAP TAGD-DLAK-LLWLKS--PSSEVWF----DRRTNYTRSLAVMS-------------MVGY mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP TAGD-DLAK-LLWLKS--PSSEVWF----DRRTNYTRSLAVMS-------------MVGY DNAPK_Mmus_DNAPK VPPD-LLKR-AFVKMS--TSPEAFL----ALRSHFASSHALLC-------------ISHW ATR_Mmus_ATR RHPP-VFHE-WFLRTF--PDPTSWY----SSRSAYCRSTAVMS-------------MVGY ATM_Mmus_ATM NFEP-VFRY-FCMEKF--LDPAVWF----EKRLAYTRSVATSS-------------IVGY ATM_Hsap_ATM NFQP-VFRY-FCMEKF--LDPAIWF----EKRLAYTRSVATSS-------------IVGY ATR_Hsap_ATR RHPP-IFHE-WFLRTF--PDPTSWY----SSRSAYCRSTAVMS-------------MVGY DNAPK_Hsap_DNAPK VPAD-LLKR-AFVRMS--TSPEAFL----ALRSHFASSHALIC-------------ISHW TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 TPPN-LLAK-ELWSSC--TTPDEWW----RVTQSYARSTAVMS-------------MVGY TRRAP_Mmus_TRRAP MVPRSMLKE-WALHTF--PNATDYW----TFRKMFTIQLALIG-------------FAEF ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM VFKP-VFRH-IFTEKH--RNPRAWF----ATRLRYTRSVAASS-------------IVGH CC1G_08126_Ccin_ATR MFPP-VFHQ-WFIETF--PDPSAWL----ENRTNYARTAAVMS-------------IVGW CC1G_00894_Ccin_FRAP TTGQ-DLYR-VLWLKS--TNSEHWL----ERRATYTRSLAVNS-------------MVGH CC1G_06302_Ccin_PI3K ------------------GTSGVEP----SVIDTFVRSCAGYC-------------VVTY CC1G_04234_Ccin_PI4K V---TLLDHFKANYGD--PSSSRFL----RAQRNFAQSLAGYS-------------IVTY CC1G_13883_Ccin_PI4K ---N-DLMG-FFVAKYGGENTVSFQ----KARLNFIQSMAAYS-------------VACY CC1G_00331_Ccin_TRRAP -LPN-VYDDINIWS-----DLVAW-----RQNVFHSINLAYVPLIENLAQSAPGGNQNTN GK008_Glam_FRAP SDAI-DLCR-SLWNKA--SSAEDWL----LKRMNYTRSIAVSS-------------IVGY GK009_Glam_PIKK-Unclassified V---TALSHMEMALSK--THPCRFIALSQKNQRMFATTLAHWC-------------AVCI TRRAP_Hsap_TRRAP VLHLNRLNPEMLQIAQDTG-KLNVAYFRFDINDATGDLDAN-----R------------- SMG1_Hsap_SMG1 IIGLGDRHLDNVLIDMTTG-EVVHIDYNVCFEKGKS-LRVP-----E------------- FRAP_Hsap_FRAP ILGLGDRHPSNLMLDRLSG-KILHIDFGDCFEVAMTREKFP-----E------------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ILGLGDRHPSNLMLDRLSG-KILHIDFGDCFEVAMTREKFP-----E------------- DNAPK_Mmus_DNAPK LLGIGDRHLNNFMVAMETG-SVIGIDFGHAFGSATQFLPVP-----E------------- ATR_Mmus_ATR ILGLGDRHGENILFDSFTG-ECVHVDFNCLFNKGET-FEVP-----E------------- ATM_Mmus_ATM ILGLGDRHVQNILINEQSA-ELVHIDLGVAFEQGKI-LPTP-----E------------- ATM_Hsap_ATM ILGLGDRHVQNILINEQSA-ELVHIDLGVAFEQGKI-LPTP-----E------------- ATR_Hsap_ATR ILGLGDRHGENILFDSLTG-ECVHVDFNCLFNKGET-FEVP-----E------------- DNAPK_Hsap_DNAPK ILGIGDRHLNNFMVAMETG-GVIGIDFGHAFGSATQFLPVP-----E------------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 IIGLGDRHLDNVLIDMTTG-EVVHIDYNVCFEKGKS-LRVP-----E------------- TRRAP_Mmus_TRRAP VLHLNRLNPEMLQIAQDTG-KLNVAYFRFDINDATGDLDAN-----R------------- ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ILGLGDRHTSNILLDNTTG-EVVHIDLGIAFDQGKL-LTIP-----E------------- CC1G_08126_Ccin_ATR ILGLGDRHCENILLDVITG-DAVHIDFNCLFEKGKV-LLTP-----E------------- CC1G_00894_Ccin_FRAP ILGLGDRHPSNLLLERSTG-KVVHIDFGDCFEVAMHREKFP-----E------------- CC1G_06302_Ccin_PI3K ILGVGDRHLDNLLIAP-DG-HFFHVDFGYILGRDPK----P-----F------------- CC1G_04234_Ccin_PI4K LLQVKDRHNGNILLDR-DG-HLIHIDFGFILSNTP-GNIGF-----E------------- CC1G_13883_Ccin_PI4K ILQIKDRHNGNIMIDG-EG-HIVHIAACAYLTLVA-LILRPGGVKFE------------- CC1G_00331_Ccin_TRRAP TYGYRGYHETAWIINRFAHVARKHGLLDVCFTYLNKIYTL-----PNIEISEAFLKLREQ GK008_Glam_FRAP ILGLGDRHPANLMIERTTG-MVLHIDYGDCFEVAMHREQLP-----E------------- GK009_Glam_PIKK-Unclassified VTGLGDRHSCNILIDTDDG-SVHFIDFEAVFEYPK-LLSYA-----E------------- TRRAP_Hsap_TRRAP -PVPFRLTPNISEFLTTIGVSG--PLTASMIA--VARCFAQPNFKVDGILKTVLRDEIIA SMG1_Hsap_SMG1 -KVPFRMTQNIETALGVTGVEG--VFRLSCEQ--VLHIMRRGRETLLTLLEAFVYDPLVD FRAP_Hsap_FRAP -KIPFRLTRMLTNAMEVTGLDG--NYRITCHT--VMEVLREHKDSVMAVLEAFVYDPLLN mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP -KIPFRLTRMLTNAMEVTGLDG--NYRTTCHT--VMEVLREHKDSVMAVLEAFVYDPLLN DNAPK_Mmus_DNAPK -LMPFRLTRQFVSLMLPMKETG--LMCTVMVH--ALRAFRSCAGLLTDTMEIFVKEPSFD ATR_Mmus_ATR -IVPFRLTHNMVNGMGPMGTEG--LFRRACEV--TLRLMRDQREPLMSVLKTFLHDPLVE ATM_Mmus_ATM -TVPFRLSRDIVDGMGITGVEG--VFRRCCEK--TMEVMRSSQETLLTIVEVLLYDPLFD ATM_Hsap_ATM -TVPFRLTRDIVDGMGITGVEG--VFRRCCEK--TMEVMRNSQETLLTIVEVLLYDPLFD ATR_Hsap_ATR -IVPFRLTHNMVNGMGPMGTEG--LFRRACEV--TMRLMRDQREPLMSVLKTFLHDPLVE DNAPK_Hsap_DNAPK -LMPFRLTRQFINLMLPMKETG--LMYSIMVH--ALRAFRSDPGLLTNTMDVFVKEPSFD TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 -KVPFRMTQNIETALGVTGVEG--VFRLSCEQ--VLHIMRRGRETLLTLLEAFVYDPLVD TRRAP_Mmus_TRRAP -PVPFRLTPNISEFLTTIGVSG--PLTASMIA--VARCFAQPNFKVDGVLKTVLRDEIIA ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM -LVPFRLTRDMVDGMGISGTQG--VFQRCAEE--TLRVLRDGSDIIMTVLEVFKHDPLHS CC1G_08126_Ccin_ATR -RVPFRLTQNIVDGLGVTGVEG--MFRIACEL--TMDLLRNNMDSLMSVLD--------- CC1G_00894_Ccin_FRAP -KVPFRLTRMLTHAMEVSGIEG--SFRNTCEI--TMTVLRDNKESLMAVLEAFVYDPLIN CC1G_06302_Ccin_PI3K -PPAVKVCKEMVDGMGGAQSPHYMRFKNYCFT--AFSILRKSANLILNLVALMVDANIPD CC1G_04234_Ccin_PI4K -AAPFKFPLEYLEVLGGIDGAGYKEFKRLFRE--GFEAARKHCDRIITLVELMQKDSSYP CC1G_13883_Ccin_PI4K -PNSFKLNHEMVQLMGGRYSQGYQLFQSLTVK--AFLAIRPYAAQIVDTVQLMLDTGLPS CC1G_00331_Ccin_TRRAP ARCHYQKPSDLQIGLEVINNTN--LMFFTAAQKAEFHTL--------------------- GK008_Glam_FRAP -KVPFRLTSIMMKAFESCGTEG--SFRMTGEA--TMSILRSNKDSLVSVLETFIYDPL-- GK009_Glam_PIKK-Unclassified -LVPFRLTALIAQLLGPTGIHG--CFYWELVK--MVSLIQENAPAFI------------- TRRAP_Hsap_TRRAP WHKKT----------QEDTSSPLSAAG--QP--------------------E-------- SMG1_Hsap_SMG1 W----------------------------------------------------------- FRAP_Hsap_FRAP WRLMDTNTK-GNK-RSRT-RTDSYSAG--QS--------------------V-------- mei-41_Dmel_ATR -d---------------------------------------------------------- CG2905_Dmel_TRRAP -d---------------------------------------------------------- CG6535_Dmel_ATM -d---------------------------------------------------------- CG4549_Dmel_SMG1 -d---------------------------------------------------------- FRAP_Mmus_FRAP WRLMDTNTK-GNK-RSRT-RTDSYSAG--QS--------------------V-------- DNAPK_Mmus_DNAPK WKSFEQTMLRKGG-SWIQ-EINVTEK---------------------------------- ATR_Mmus_ATR WSKP---VK-GHS-KA-----PLNETG--EV--------------------V-------- ATM_Mmus_ATM WTMNPLKALYLQQ-RPED-ESDLHSTP--NA--------------------D-------- ATM_Hsap_ATM WTMNPLKALYLQQ-RPED-ETELHPTL--NA--------------------D-------- ATR_Hsap_ATR WSKP---VK-GHS-KA-----PLNETG--EV--------------------V-------- DNAPK_Hsap_DNAPK WKNFEQKMLKKGG-SWIQ-EINVAEK---------------------------------- TOR_Dmel_FRAP -d---------------------------------------------------------- SMG1_Mmus_SMG1 W----------------------------------------------------------- TRRAP_Mmus_TRRAP WHKKT----------QEDTSSPLSAAG--QP--------------------E-------- ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM WTASEIKIKRVQQ-PEAPPTTPASEAGANQPKILPSRFELGGLGIDMTSGTA-------- CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP W----------------------------------------------------------- CC1G_06302_Ccin_PI3K IKHRDVHE-QIQE-K---FRLDLSEEDAI------------------------------- CC1G_04234_Ccin_PI4K CFA-------------------V-SAD--QT--------------------A-------- CC1G_13883_Ccin_PI4K FKGEPT-IRRLRD-R---FTLSLSERQAA------------------------------- CC1G_00331_Ccin_TRRAP ------KGMFYARLGRLD--EASAAFG--QA--------------------VQLDMTQAK GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ---------NMDSQQLV-SLV---------------------------------QK---- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ---------EILDGVELGEPAHKKTG-------------------------TTVPE---- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ---------EILDGVELGEPAHKKAG-------------------------TTVPE---- DNAPK_Mmus_DNAPK ---------NWYPQHKIR-YAKRKLA------------GA---------N-PAV-I---- ATR_Mmus_ATR ---------NEKAKTHVLD-IEQRLQ------------GVIKTRNRVTGLPLSIEG---- ATM_Mmus_ATM ---------DQECKQSLSD-TDQSFN--------------------------KVAE---- ATM_Hsap_ATM ---------DQECKRNLSD-IDQSFN--------------------------KVAE---- ATR_Hsap_ATR ---------NEKAKTHVLD-IEQRLQ------------GVIKTRNRVTGLPLSIEG---- DNAPK_Hsap_DNAPK ---------NWYPRQKIC-YAKRKLA------------GA---------N-PAV-I---- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ---------NMDSQQLV-SLV---------------------------------QK---- ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ---------EEAADRALSS-VARKLD------------K-----------SLSVES---- CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ----------KHFETLLNE--TSYFT--------------------------VVLD---- CC1G_04234_Ccin_PI4K ---------NQLRDRFMPTLT-HSLV------------GE------------HVERLIAS CC1G_13883_Ccin_PI4K ----------DYMMGVIR-NAHENVR-------------------------STAYD---- CC1G_00331_Ccin_TRRAP VWAEWGRYNDQRFKENPAD-LTLAASAVSCYLQAAGLYK--------CG--KSR-P---- GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ---A------------VTAIMTR SMG1_Hsap_SMG1 ----------------------T FRAP_Hsap_FRAP --SI------------HSFIGDG mei-41_Dmel_ATR -----------------kinase CG2905_Dmel_TRRAP -----------------kinase CG6535_Dmel_ATM -----------------kinase CG4549_Dmel_SMG1 -----------------kinase FRAP_Mmus_FRAP --SI------------HSFIGDG DNAPK_Mmus_DNAPK --TC------------DELYLGH ATR_Mmus_ATR --HV------------HYLIQEA ATM_Mmus_ATM --RV------------LMRLQEK ATM_Hsap_ATM --RV------------LMRLQEK ATR_Hsap_ATR --HV------------HYLIQEA DNAPK_Hsap_DNAPK --TC------------DELLLGH TOR_Dmel_FRAP -----------------kinase SMG1_Mmus_SMG1 ----------------------T TRRAP_Mmus_TRRAP ---A------------VTAIMTR ATR_Ddis_ATR -----------------ypical DNAPK_Ddis_DNAPK -----------------ypical SMG1_Ddis_SMG1 -----------------ypical Tor_Ddis_FRAP -----------------ypical TRRAP_Ddis_TRRAP -----------------ypical CC1G_00839_Ccin_ATM --TVNELIAIATDPTNLGKIFYG CC1G_08126_Ccin_ATR ---------------------AF CC1G_00894_Ccin_FRAP ---------------------RL CC1G_06302_Ccin_PI3K --RI------------HDLAQYW CC1G_04234_Ccin_PI4K SLGS------------HWTRLYD CC1G_13883_Ccin_PI4K --EF------------QRLQNGI CC1G_00331_Ccin_TRRAP --LL------------MRVLYLL GK008_Glam_FRAP --------------------MSM GK009_Glam_PIKK-Unclassified --------------------NVF