CLUSTAL W (1.83) multiple sequence alignment PLK4_Hsap_SAK -FKVGNLLGKGSFAGVYRAESIHT--GLEVAIKMIDKKAM-------------------- PLK3_Hsap_PLK2 -YLKGRLLGKGGFARCYEATDTET--GSAYAVKVIPQSRV-------------------- PLK2_Hsap_PLK2 -YCRGKVLGKGGFAKCYEMTDLTN--NKVYAAKIIPHSRV-------------------- PLK1_Hsap_PLK1 ------FLGKGGFAKCFEISDADT--KEVFAGKIVPKSLL-------------------- polo_Dmel_PLK1 -YKRMRFFGKGGFAKCYEIIDVET--DDVFAGKIVSKKLM-------------------- SAK_Dmel_SAK -YEVQHLLGKGGFATVYKARCLHT--HQDVAIKMIDKKLI-------------------- PLK5_Mmus_PLK2 -YRRGKLIGKGAFSRCYKLTDMST--SAVFALKVVPRGGA-------------------- PLK4_Mmus_SAK -FKVGNLLGKGSFAGVYRAESIHT--GLEVAIKMIDKKAM-------------------- PLK3_Mmus_PLK2 -YTKGRLLGKGGFARCYEATDTES--GIAYAVKVIPQSRV-------------------- PLK2_Mmus_PLK2 -YCRGKVLGKGGFAKCYEMTDLTN--NKVYAAKIIPHSRV-------------------- PLK1_Mmus_PLK1 ------FLGKGGFAKCFEISDADT--KEVFAGKIVPKSLL-------------------- plk-2_Cele_PLK1 -YEKGKFLGKGGFAHCYELRNKST--GELFAGKVVPKALL-------------------- plk-1_Cele_PLK1 -YEKGRFLGKGGFAHCYELTNRAT--REVVAGKVVPKSML-------------------- F55G1.8_Cele_PLK1 -YEKGAFLGEGGFAHCFEFRKLDC--NDRLAVKVVPKVIL-------------------- CDC5_Scer_PLK1 -YHRGHFLGEGGFARCFQIKDD-S--GEIFAAKTVAKASI-------------------- zyg-1_Cele_SAK -YSHLKEIGKGGFGVVYAAQR-EN--GEKVAIKRVSFMLFSKDIRMGQFFYFFSLQKLYF PLK_Ddis_PLK1 -YRQGEFLGKGGFAKCYLMTEVET--NRIYAAKIIPKSTL-------------------- 8635_Tthe_SAK ------------------------------AMKVVDKKRK-------------------- 8635~b_Tthe_SAK -----------------------DQS--EINEQIKRQSQI-------------------- 18358b_Tthe_PLK-Unclassified ---------KGGFAKCYEFTNLER--KQVLAAKVIPKSSL-------------------- 18380_Tthe_PLK-Unclassified -YSRGKLLGSGGFAKCYEVIALDTDPKAIFAAKIIPKSTL-------------------- 21183_Tthe_SAK ------------------------------------------------------------ 22503_Tthe_PLK-Unclassified -YEVLSKLGKGGFAKVYLAKDISS--NEQYAIKVVDKSSL-------------------- 5034_Tthe_SAK -YIISHPIGSGAGSLVVKVKSIKT--KKEYAIKVVDKQSQ-------------------- 8829_Tthe_PLK-Unclassified -YLRGKLLGKGGFAKCYEVTNLET--KKIIAAKIIPKQTL-------------------- SAK_Spur_SAK -YQVLNLLGRGGFACVYRAKTIST--GQEVAIKMIDKKLM-------------------- PLK1_Spur_PLK1 -YTKGRFLGKGGFAKCYELTDDAT--KQIFAGKVVSKALL-------------------- PLK2_Spur_PLK2 ----------GGFARCYELTHLDT--HYVYAGKIVPKERI-------------------- n1170_Tthe_PLK-Unclassified -YQRGSLLGKGGFAKCFQVTNLEN--KKVMAAKIIPKSTL-------------------- n808_Tthe_PLK-Unclassified -YQRGSLLGKGGFAKCFQVTNLEN--KKVMAAKIIPKSTL-------------------- CC1G_07437_Ccin_PLK1 -FNRVGFLGEGGFARVYEVQDP-R--GSRLACKVVTKSAL-------------------- AqueK200_Aque_PLK1 -YEKGRFLGKGGFAKCYELICEET--GTVYAGKIVAKELL-------------------- AqueK201_Aque_SAK DYEVLNRLGKGSFADVYRAKCKRT--KKEVAIKMIDKKLM-------------------- GK066_Glam_PLK-Unclassified -YRPGKLLGKGGFAYVYEFHDVNS--DSSYACKITPRSAL-------------------- PLK4_Hsap_SAK --YKAGMVQRVQNEVKIHCQLKH-PSILELYNYFEDSNYVYLVLEMCHNG----EMNRYL PLK3_Hsap_PLK2 --AKPHQREKILNEIELHRDLQH-RHIVRFSHHFEDADNIYIFLELCSRK----SLAHIW PLK2_Hsap_PLK2 --AKPHQREKIDKEIELHRILHH-KHVVQFYHYFEDKENIYILLEYCSRR----SMAHIL PLK1_Hsap_PLK1 --LKPHQREKMSMEISIHRSLAH-QHVVGFHGFFEDNDFVFVVLELCRRR----SLLELH polo_Dmel_PLK1 --IKHNQKEKTAQEITIHRSLNH-PNIVKFHNYFEDSQNIYIVLELCKKR----SMMELH SAK_Dmel_SAK --QGTGLTNRVRQEVEIHSRLKH-PSVLQLYTFFQDANYVYLVLELAHNG----ELHRYM PLK5_Mmus_PLK2 --GRLRLRGKVEREIALHSRLRH-RNIVAFHAHFADRDHVYMVLEYCSRQVPLQSLAHVL PLK4_Mmus_SAK --YKAGMVQRVQNEVKIHCQLKH-PSVLELYNYFEDNNYVYLVLEMCHNG----EMNRYL PLK3_Mmus_PLK2 --AKPHQREKILNEIELHRDLQH-RHIVRFSHHFEDADNIYIFLELCSRK----SLAHIW PLK2_Mmus_PLK2 --AKPHQREKIDKEIELHRLLHH-KHVVQFYHYFEDKENIYILLEYCSRR----SMAHIL PLK1_Mmus_PLK1 --LKPHQKEKMSMEISIHRSLAH-QHVVGFHDFFEDSDFVFVVLELCRRR----SLLELH plk-2_Cele_PLK1 --IKQYQRDKMAQEVQIHRNLQH-RNVVKLYHFFEDKSNVYITLELCPRR----SLMELH plk-1_Cele_PLK1 --VKQYQRDKMTQEVQIHRELGH-INIVKLFNFFEDNLNVYITLELCARR----SLMELH F55G1.8_Cele_PLK1 --LKSTAREKLTREVEIHRQLSH-RNIVQFHHFFEDSQNVYFTLELCSKN----SLMELN CDC5_Scer_PLK1 --KSEKTRKKLLSEIQIHKSMSH-PNIVQFIDCFEDDSNVYILLEICPNG----SLMELL zyg-1_Cele_SAK QIDKKVPKNRVWTEIQTMKELKKSKYVVEFYEDFVEDGYTYIVMELCEGG----SLQAYV PLK_Ddis_PLK1 --QKTRARSKLKSEIKIHSSLSH-ENIVKFEHCFENEENVYILLELCNQK----TVMDIH 8635_Tthe_SAK --DIQNVMKRLDQEIKIQKELDH-PNIIKLFKHFEDDQNHYLIMELAQNG----EIKDYL 8635~b_Tthe_SAK --VQKKDDLKILNEIEIIGDIQNI-EQINKGGFGS-----------IQKG----KLAKIL 18358b_Tthe_PLK-Unclassified --TKSRARQKLMSEIRIHKSLNH-RNIVKFQHFFEDQENVYILLEMCTNQ----TMNELI 18380_Tthe_PLK-Unclassified --TKSRQRVKLISEIKIHKSLHH-KNIVQFEHVFEDHDNVYILLELCPYQ----TLNELI 21183_Tthe_SAK ----------------LHSQLDH-PNIVKILKRFEDNEYVYMMLEYCPGG----SLFDYI 22503_Tthe_PLK-Unclassified --EKDSFKEKLNQEIKIQKSLNH-ENVVKYYTSFEDSQNVYIVLEYCSNQ----EL---L 5034_Tthe_SAK --YYKSAYKRLKNEIEIHLDLKH-KNIVKMIKSFEDSENLYLVMEYCEGG----DLFHYL 8829_Tthe_PLK-Unclassified --TKNRARQKLISEIKIHKSLNH-QHVVAFEHVFEDHENVYILLELCTNH----TLNELI SAK_Spur_SAK --QSSGMATRVKNEVEIHCQLKH-PSILELYSYFEDNNYVYLVLELAQNG----ELLRYL PLK1_Spur_PLK1 --VKPHQKDKMTMEIHIHKSLHH-RHVVGFHSFFEDKENVYVLLELCRRR----SLMELH PLK2_Spur_PLK2 --SKPSQREKMEREIAVHAQLRH-PHIVGFHKHFQDAENIYILLELCRHK----SLLHML n1170_Tthe_PLK-Unclassified --VKNRARQKLISEIKIHKSLHH-NNIVKFEHVFEDHDNVYILLELCPHQ----TLNELI n808_Tthe_PLK-Unclassified --VKNRARQKLISEIKIHKSLHH-NNIVKFEHVFEDHDNVYILLELCPHQ----TLNELI CC1G_07437_Ccin_PLK1 --KTKKAKTKLYAEIKIHRSLDH-PNIVTFIDCFEDEDNVYITLELCPSG----SLMDML AqueK200_Aque_PLK1 --VKPHQKEKMTQEIEIHRSLSH-KHVVGFHGFFDDSNNVYILLELCKRR----SLMELH AqueK201_Aque_SAK --VKKGMTERVKNEVKIHSHLKH-PSILELYDFFEDSNYVYLILEFCQNG----ELNRYL GK066_Glam_PLK-Unclassified --QKKKYYDKFVTEVTIHRGLVH-PNICRVLNVFKDQMNYYIILEKCNGG----TLTDLI : : : PLK4_Hsap_SAK -------KN-----RVKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTR--- PLK3_Hsap_PLK2 -------KA-----R-HTLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFITE--- PLK2_Hsap_PLK2 -------KA-----R-KVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINE--- PLK1_Hsap_PLK1 -------KR-----R-KALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNE--- polo_Dmel_PLK1 -------KR-----R-KSITEFECRYYIYQIIQGVKYLHDNRIIHRDLKLGNLFLND--- SAK_Dmel_SAK -------NH-----IARPFTETEAASILKQVVAGLLYLHSHNIMHRDISLSNLLLSR--- PLK5_Mmus_PLK2 -------KV-----R-RTLTEPEVRYYLRGLVSGLRYLHQQRIVHRDLKPSNFFLNK--- PLK4_Mmus_SAK -------KN-----RMKPFSEREARHFMHQIITGMLYLHSHGILHRDLTLSNILLTR--- PLK3_Mmus_PLK2 -------KA-----R-HTLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFITD--- PLK2_Mmus_PLK2 -------KA-----R-KVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINE--- PLK1_Mmus_PLK1 -------KR-----R-KALTEPEARYYLRQIVLGCQYLHRNQVIHRDLKLGNLFLNE--- plk-2_Cele_PLK1 -------KR-----R-KAVTEPEARYFTYQIVEGVLYLHNLKIVHRDLKLGNLFLND--- plk-1_Cele_PLK1 -------KR-----R-KAVTEPEARYFTHQIVDGVLYLHDLNIIHRDMKLGNLFLND--- F55G1.8_Cele_PLK1 -------KQ-----R-GPLTEHEARFYTIQVAEGVKHLHNLQIIHRDLKLGNLFLNE--- CDC5_Scer_PLK1 -------KR-----R-KVLTEPEVRFFTTQICGAIKYMHSRRVIHRDLKLGNIFFDS--- zyg-1_Cele_SAK -------RE-----H-GALDDATAVHVLRQLISAVSFMHRVNVIHRDLSAGNVFIKDSKK PLK_Ddis_PLK1 -------KK-----R-KYLMEYETKYYVYQVIMAVQYLHNNNIIHRDLKLGNLFI-D--- 8635_Tthe_SAK -------NI-----N-K----------PYQLACGIKYLHDKDIVHRDLKLNNVLLSN--- 8635~b_Tthe_SAK -------KYPLYGHFSQTMSLITKLYIMWQIAQGIQFLTSKNVAHLDLKPANIVISK--- 18358b_Tthe_PLK-Unclassified -------RR-----R-KRLTELEVQCYLLQILYSIKYLHDNRVIHRDLKLGNLFLSD--- 18380_Tthe_PLK-Unclassified -------KR-----R-KRITEYETQIYVMQIVNALKYLHQNKIIHRDLKLGNLFLGD--- 21183_Tthe_SAK VYINFQLFE-----K-TRLNEDEARDISYQIVQGLEYLHKNKIIHRDLKPGNILLTG--- 22503_Tthe_PLK-Unclassified -------DR-----R-KRLTEIEVKSHLFQIIQSLKYIHSKGVIHRDLKIANIFLND--- 5034_Tthe_SAK -------KH-----H-KKLSETEAKRITYKLAEGLKYLHDKSIIHRDLKLGNVLLSS--- 8829_Tthe_PLK-Unclassified -------KR-----R-KRLTELEVQCYVVQIVNALKYLHSHKVIHRDLKLGNLFLNE--- SAK_Spur_SAK -------KK-----KARVFGEEEARQFLEEIVIGLLYLHSHGILHRDLTLANILLTR--- PLK1_Spur_PLK1 -------KR-----R-KAITEPETRYFMRQCILACQYLSKTKVIHRDLKLGNLFIDD--- PLK2_Spur_PLK2 -------KL-----R-KHLTEPEVRYFMLQIIEGVRYLHSHCVIHRDLKLGNMFLTD--- n1170_Tthe_PLK-Unclassified -------KR-----R-KRITELETLCYTVQIVQALKYLHQNRVIHRDLKLGNLFVGE--- n808_Tthe_PLK-Unclassified -------KR-----R-KRITELETLCYTVQIVQALKYLHQNRVIHRDLKLGNLFVGE--- CC1G_07437_Ccin_PLK1 -------RR-----R-RRFTEPETRFFMVQLIGACHYMHTHQVIHRDLKLGNLFLDA--- AqueK200_Aque_PLK1 -------KR-----R-KALTEPEVRYLFRQTVLAVDYLHDVKVIHRDLKLGNLFLND--- AqueK201_Aque_SAK -------KH-----RQKSLSE-DERIILNQVVKGLIYLHSFNIVHRDLSLSNILLTS--- GK066_Glam_PLK-Unclassified -------RR-----R-KHLTETEARFFSKRILNALWYLHDLYIIHRDIKTSNIFLME--- . .: : * *:. *... PLK4_Hsap_SAK -NMNIKIADFGLATQLKMPH-------------EKHYTLCGTPNYISPEI---------- PLK3_Hsap_PLK2 -NMELKVGDFGLAARLEPPE-------------QRKKTICGTPNYVAPEV---------- PLK2_Hsap_PLK2 -AMELKVGDFGLAARLEPLE-------------HRRRTICGTPNYLSPEV---------- PLK1_Hsap_PLK1 -DLEVKIGDFGLATKVEYDG-------------ERKKTLCGTPNYIAPEV---------- polo_Dmel_PLK1 -LLHVKIGDFGLATRIEYEG-------------ERKKTLCGTPNYIAPEI---------- SAK_Dmel_SAK -EMHVKIADFGLATQLKRPD-------------ERHMTMCGTPNYISPEV---------- PLK5_Mmus_PLK2 -NMEVKIGDLGLAARVGPAG-------------RCHRVLCGTPNFQAPEV---------- PLK4_Mmus_SAK -NMNIKIADFGLATQLNMPH-------------EKHYTLCGTPNYISPEI---------- PLK3_Mmus_PLK2 -NMELKVGDFGLAARLEPPE-------------QRKKTICGTPNYVAPEV---------- PLK2_Mmus_PLK2 -AMELKVGDFGLAARLEPLE-------------HRRRTICGTPNYLSPEV---------- PLK1_Mmus_PLK1 -DLEVKIGDFGLATKVEYEG-------------ERKKTLCGTPNYIAPEV---------- plk-2_Cele_PLK1 -ELQVKIGDFGLATTCDN-D-------------ERKKTLCGTPNYIAPEV---------- plk-1_Cele_PLK1 -DLVVKIGDFGLATTVNG-D-------------ERKKTLCGTPNYIAPEV---------- F55G1.8_Cele_PLK1 -HLQVKIGDFGLATFCEK-N-------------EKKMTRGGTPNYIAPEV---------- CDC5_Scer_PLK1 -NYNLKIGDFGLAAVLANES-------------ERKYTICGTPNYIAPEV---------- zyg-1_Cele_SAK KKMTVKLGDFGLATTLGR-G-------------ETTCTIVGTPGFIAPQV---------- PLK_Ddis_PLK1 -NMRIKLGDFGLSTKVEH-G-------------ERKKTICGTPNYIAPEI---------- 8635_Tthe_SAK --GKIKIADFGLATKVNDEN-------------PECNTMCGTANYLSPEI---------- 8635~b_Tthe_SAK -GYLAKIIDFGEAYHPDVCNGKEFYNNQQRLIFKSYFLMKGNPNYKPGRT---------- 18358b_Tthe_PLK-Unclassified -KMEIKLGDFGLATKLEYDG-------------ERKRTICGTPNYIAPEI---------- 18380_Tthe_PLK-Unclassified -NMTLKIGDFGLATKIEYEG-------------EKKKTVCGTPNYIAPEI---------- 21183_Tthe_SAK -NNSVKICDFGLAVRVTNYE-------------SERDTFCGTPNYIAPEK---------- 22503_Tthe_PLK-Unclassified -KMVVKLADFGLSAMMKN-A-------------QKRKTVCGTPNYIAPEV---------- 5034_Tthe_SAK -DHQVKICDFGLAVRLNGNE-------------QEKNTICGTPNYISPEI---------- 8829_Tthe_PLK-Unclassified -KMEIKLGDFGLATKLEFDG-------------EKKHTICGTPNYIAPEI---------- SAK_Spur_SAK -DMHCKIADFGLAAQLKLPE-------------EQHYTMCGTPNYISPEI---------- PLK1_Spur_PLK1 -NMELKVGDFGLATKVDFSG-------------ERKKTLCGTPNYIAPEV---------- PLK2_Spur_PLK2 -TMGVKIGDFGLAAKLEFEG-------------DRKRTMCGTPNYIAPEV---------- n1170_Tthe_PLK-Unclassified -KMEIKLGDFGLATKLEFDG-------------EKKRTICGTPNYIAPEI---------- n808_Tthe_PLK-Unclassified -KMEIKLGDFGLATKLEFDG-------------EKKRTICGTPNYIAPEI---------- CC1G_07437_Ccin_PLK1 -NMNVKVGDFGLAALIENPG-------------ERKKTICGTPNYIAPEV---------- AqueK200_Aque_PLK1 -DIEIKLGDFGLATRLEEDG-------------ERKKTLCGTPNYIAPEV---------- AqueK201_Aque_SAK -SMDIKIADFGLSVTLDLPG-------------DKHHTLCGTPNYIAPYVICCYEGCFLI GK066_Glam_PLK-Unclassified -DFDVKVGDFGLAVKCETPE-------------ELHWTMCGTPNFLPSEV---------- *: *:* : *...: . PLK4_Hsap_SAK -------AT---------------------------------------RSAHGLESDVWS PLK3_Hsap_PLK2 -------LL---------------------------------------RQGHGPEADVWS PLK2_Hsap_PLK2 -------LN---------------------------------------KQGHGCESDIWA PLK1_Hsap_PLK1 -------LS---------------------------------------KKGHSFEVDVWS polo_Dmel_PLK1 -------LT---------------------------------------KKGHSFEVDIWS SAK_Dmel_SAK -------VS---------------------------------------RTSHGLPADVWS PLK5_Mmus_PLK2 -------VS---------------------------------------RNGHSCKSDIWA PLK4_Mmus_SAK -------AT---------------------------------------RSAHGLESDIWS PLK3_Mmus_PLK2 -------LL---------------------------------------RQGHGPEADVWS PLK2_Mmus_PLK2 -------LN---------------------------------------KQGHGCESDIWA PLK1_Mmus_PLK1 -------LS---------------------------------------KKGHSFEVDVWS plk-2_Cele_PLK1 -------LN---------------------------------------KIGHSFEVDLWA plk-1_Cele_PLK1 -------LN---------------------------------------KAGHSFEVDIWA F55G1.8_Cele_PLK1 -------LN---------------------------------------ETGHAFEVDIWA CDC5_Scer_PLK1 -------LMG-------------------------------------KHSGHSFEVDIWS zyg-1_Cele_SAK -------YD---------------------------------------Q-EYTQSADVYS PLK_Ddis_PLK1 -------LD--------------------------------------NSNGHSYEVDVWS 8635_Tthe_SAK -------LN---------------------------------------SKGYGKKTDIWS 8635~b_Tthe_SAK -------LPYTPYSNNN------------------------------DRQASYKNLDIFS 18358b_Tthe_PLK-Unclassified -------LEA-------------------------------------KETGHSYEVDVWS 18380_Tthe_PLK-Unclassified -------LE--------------------------------------GKDGHSYEVDMWS 21183_Tthe_SAK ---------------------------------------------------YGIQSDCWS 22503_Tthe_PLK-Unclassified -------LK---------------------------------------NQGHDYLVDNWA 5034_Tthe_SAK -------LN---------------------------------------KQPYGMKIDCWS 8829_Tthe_PLK-Unclassified -------LD--------------------------------------GKTGHSYQVDIWS SAK_Spur_SAK -------AT---------------------------------------RGPHGLQSDVWS PLK1_Spur_PLK1 -------LS---------------------------------------KKGHSYEVDLWS PLK2_Spur_PLK2 -------LG---------------------------------------KIGHSFEADVWA n1170_Tthe_PLK-Unclassified -------LD--------------------------------------GRVGHSYEVDIWS n808_Tthe_PLK-Unclassified -------LD--------------------------------------GRVGHSYEVDIWS CC1G_07437_Ccin_PLK1 -------LFD-------------------------------------TANGHSFEVDIWS AqueK200_Aque_PLK1 -------LT---------------------------------------KKGHSYEVDIWS AqueK201_Aque_SAK FIFCREVAK---------------------------------------REAHGLESDIWS GK066_Glam_PLK-Unclassified -------IYS------HIMKRKASGRGPDPNLDEDCVNLCHQLLPAYSGQGHSFSADMWS * :: PLK4_Hsap_SAK LGCMFYTLLIGRPPFDTDT--VKN---TLNK-------VV-LAD--YEMPS--FLSIEAK PLK3_Hsap_PLK2 LGCVMYTLLCGSPPFETAD--LKE---TYRC-------IK-QVH--YTLPAS--LSLPAR PLK2_Hsap_PLK2 LGCVMYTMLLGRPPFETTN--LKE---TYRC-------IR-EAR--YTMPSS--LLAPAK PLK1_Hsap_PLK1 IGCIMYTLLVGKPPFETSC--LKE---TYLR-------IK-KNE--YSIPKH--INPVAA polo_Dmel_PLK1 IGCVMYTLLVGQPPFETKT--LKD---TYSK-------IK-KCE--YRVPSY--LRKPAA SAK_Dmel_SAK VGCMLYTLLVGRPPFETDA--VQS---TLNK-------VV-MSE--YIMPA--HLSYEAQ PLK5_Mmus_PLK2 LGCIMYTVLTGTPPFAAAP--LSE---MYQN-------IR-DGH--YLEPTH--LSPSAR PLK4_Mmus_SAK LGCMFYTLLIGRPPFDTDT--VKN---TLNK-------VV-LAD--YEMPA--FLSREAQ PLK3_Mmus_PLK2 LGCVMYTLLCGSPPFETAD--LKE---TYRC-------IK-QVH--YTLPAS--LSLPAR PLK2_Mmus_PLK2 LGCVMYTMLLGRPPFETTN--LKE---TYRC-------IR-EAR--YTMPSS--LLAPAK PLK1_Mmus_PLK1 IGCIMYTLLVGKPPFETSC--LKE---TYLR-------IK-KNE--YSIPKH--INPVAA plk-2_Cele_PLK1 IGCILYILLFGHPPFESKS--LEE---TYSR-------IK-NNN--YVIPTS--ASAAAS plk-1_Cele_PLK1 VGCILYILLFGQPPFESKS--LEE---TYSR-------IR-HNN--YTIPSI--ATQPAA F55G1.8_Cele_PLK1 IGCILYVLLFGSPPFESRR--VQE---TYVR-------IK-NND--YVVPEN--ASPTAN CDC5_Scer_PLK1 LGVMLYALLIGKPPFQARD--VNT---IYER-------IK-CRD--FSFPRDKPISDEGK zyg-1_Cele_SAK LGAVLYTMLTARNPPPK------------------------------GLPPTCGMSPNAA PLK_Ddis_PLK1 IGIILYTLLIGKPPFETSD--VKH---TYQR-------IK-QNQ--YSFPDEPIISHYGK 8635_Tthe_SAK FGCILYALCSGNLPFFSGN--PSQ---TIQN-------IK-EGK--WQLPQNI--SDNVK 8635~b_Tthe_SAK FGMVLSEIVFDTYPVDFKRGALHKLEEKFSRGDIRGRLV-KNYQRH-FGPKH--IINLLH 18358b_Tthe_PLK-Unclassified FGVIAYTLLIGKPPFETND--VKS---TYKK-------IR-TNE--YSFPEQIQISSAAK 18380_Tthe_PLK-Unclassified LGVIIYTLLIGKPPFETKD--VRT---TYKR-------IK-MNN--YCFPEQIQISDNAK 21183_Tthe_SAK FGCILYTIATGRPPFETVS--IQQ---TLKM-------LQKKNK--VEYPSHL--SKSLV 22503_Tthe_PLK-Unclassified IGVIVYTFLIGKPPFEEKE--VEN---TLRN-------IK-ANR--YSFPENCTISKEAK 5034_Tthe_SAK FGCILYALIVGHPPFQGQD--IVQ---TLKK-------VT-SQEQFFELPNNI--SDNLK 8829_Tthe_PLK-Unclassified LGVIIYTLLIGKPPFETPD--VKT---TYKK-------IR-NIS--YGFPENVPISDQAR SAK_Spur_SAK LGCMLYTFLTGTPPFDTEA--VKT---TLNK-------VM-LAE--YIIPT--HISMEAK PLK1_Spur_PLK1 LGCIMYTLLVGKPPFETQS--LKD---TYQR-------IK-RNE--YRVPSH--VSTPAR PLK2_Spur_PLK2 LGCIMYTMLVGRPPFETSS--LKE---TYAR-------IK-HNK--YHFPET--LSPVAK n1170_Tthe_PLK-Unclassified LGVILYTLLIGKPPFETHD--VKT---TYRK-------IK-SNQ--YSFPDHAPIPDSAK n808_Tthe_PLK-Unclassified LGVILYTLLIGK------------------------------------------------ CC1G_07437_Ccin_PLK1 IGVILYTLVIGRPPFQTKE--VKE---IYKR-------IR-DNE--YEFPAERAISTAVK AqueK200_Aque_PLK1 LGCILYTLLVGKPPFETKT--LKD---TYQR-------IK-RNE--YHIPHY--VGPEAR AqueK201_Aque_SAK LGCMVYTMLVGTPPFDTDD--VQS---TLDN-------VV-NGD--FDIPQ--YITTNCT GK066_Glam_PLK-Unclassified FGCLVFSMIYGRPPFEAAD--IKT---TYKR-------IV-RCD--FSFPGSISVSEDLK .* : . PLK4_Hsap_SAK DLIHQLLRRNPADRLSLSSVLDHPFM PLK3_Hsap_PLK2 QLLAAILRASPRDRPSIDQILRHDFF PLK2_Hsap_PLK2 HLIASMLSKNPEDRPSLDDIIRHDFF PLK1_Hsap_PLK1 SLIQKMLQTDPTARPTINELLNDEFF polo_Dmel_PLK1 DMVIAMLQPNPESRPAIGQLLNFEFL SAK_Dmel_SAK DLINKLLKKLPHERITLEAVLCHPFM PLK5_Mmus_PLK2 SLIARLLAPDPAERPSLDHLLQDDFF PLK4_Mmus_SAK DLIHQLLRRNPADRLSLSSVLDHPFM PLK3_Mmus_PLK2 QLLAAILRASPRDRPSIEQILRHDFF PLK2_Mmus_PLK2 HLIASMLSKNPEDRPSLDDIIRHDFF PLK1_Mmus_PLK1 SLIQKMLQTDPTARPTIHELLNDEFF plk-2_Cele_PLK1 QLIRVLLDPVPSRRPNARAVCRDHFF plk-1_Cele_PLK1 SLIRKMLDPEPTRRPTAKQVIS---I F55G1.8_Cele_PLK1 RLIRSLLDPVPDRRPTAEAVLLDQFF CDC5_Scer_PLK1 ILIRDILSLDPIERPSLTEIMDYVWF zyg-1_Cele_SAK RLVEQMMDTDAKKRIPLTQIVLSEFM PLK_Ddis_PLK1 SLIISILNPVPEQRPNLTQILEHD-F 8635_Tthe_SAK DLLSNTLNWDQNSRFSIEQVLSHKFY 8635~b_Tthe_SAK CLIFRCID-EKENRPTIDWII---LI 18358b_Tthe_PLK-Unclassified NMIKKILTTDPSKRPTINELFNDDFF 18380_Tthe_PLK-Unclassified SIITSILNLNPQKRLTLDELLEHPFM 21183_Tthe_SAK DLIDHILDWNQDTRYNISQIKSHPFY 22503_Tthe_PLK-Unclassified DFIQKILVPNPDQRLTMDQMLQHPFM 5034_Tthe_SAK DLLVNIINWNQDSRFTIDQILMHPFY 8829_Tthe_PLK-Unclassified GLITRILNIDPQRRPTLDEIMSSSFL SAK_Spur_SAK DLINKMLRKDPTERIGLSTVLDHPFM PLK1_Spur_PLK1 NLIVKLLKNDPTQRPHIDILLQDEFF PLK2_Spur_PLK2 EIISDLLSSDPEERPPLEVVIDHEFF n1170_Tthe_PLK-Unclassified ALIQLILQQDPAKRPTLDEILAHPFI n808_Tthe_PLK-Unclassified -------------------------N CC1G_07437_Ccin_PLK1 VLIQQILTPDPSQRPTLHEIIEDTFF AqueK200_Aque_PLK1 TLISNLLRPNPANRPTAAEILKDPFF AqueK201_Aque_SAK SLNL--HVYHPSKRLTLQQVLYHS-F GK066_Glam_PLK-Unclassified NFIKGLLTPDPRKRFTVKECLDHSWL