CLUSTAL W (1.83) multiple sequence alignment HSER_Hsap LKIDDDK----------------------------------R---R-------------- CG10738_Dmel TT---------------------------------------------------------- CG9783_Dmel TTANGKS----------------------------------GSS-------ATG------ Gyc32E_Dmel QSIL------------------VV-----------------GEPN--------------- Gyc76C_Dmel LEIEGLLWKIDPNEIKGYSGNEIV-----------------SSPSK--VSLMSA------ CG4224_Dmel Q----------------------------------------------------------- CG3216_Dmel P----------------------------------------------------------- KSGC_Mmus SLVK-------------------R------------------------------------ HSER_Mmus LKIDDDR----------------------------------R---R-------------- CYGX_Mmus RSVVD------------------G-----------------G-SPR---SVTQG------ CYGF_Mmus FQIISEV---------------QS-----------------GRSPR--LSFSSG------ CYGD_Mmus RSAS-------------------------------------------------------- ANPb_Mmus GSRLTLS---------------L-------------------RG------SSYG------ ANPa_Mmus GSRLTLS---------------G-------------------RG------SNYG------ odr-1_Cele FGSYALV---------------GT------------------------------------ gcy-9_Cele SKQNGLI---------------AA-----------------K------------------ gcy-8_Cele SRNHAIV---------------GT------------------------------------ gcy-7_Cele ----------------------------------QINSKQKGKGEHSVRSLQSGTSTLSS gcy-6_Cele ----------------------------------E------------------------- gcy-5_Cele QM--------------------------------FE------------------------ gcy-4_Cele SKSGDTM---------------TSEFKETYTIQYLE------------------------ gcy-3_Cele ----------------------------------FE------------------------ gcy-27_Cele FGSYALI---------------GT------------------------------------ gcy-25_Cele ------------------------------------------------------------ gcy-23_Cele VKHHAVV---------------GT------------------------------------ gcy-22_Cele ----------------------------------N------------------------- gcy-21_Cele EG---------------------------------------------------------- gcy-20_Cele ----------------------------------H------------------------- gcy-2_Cele ----------------------------------YE------------------------ gcy-19_Cele -----------------------------------D------------------------ gcy-18_Cele QKQHAII---------------GV------------------------------------ gcy-17_Cele ----------------------------------L------------------------- gcy-15_Cele EG---------------------------------------------------------- gcy-14_Cele ----------------------------------Q------------------------- gcy-13_Cele ----------------------------------YM------------------------ gcy-12_Cele YEVRRVV---------------GG-----------------VN-NE-----STA------ gcy-11_Cele ------------------------------------------------------------ gcy-1_Cele ----------------------------------YE------------------------ daf-11_Cele MEEKQRL---------------QS------------------------------------ C04H5.4_Cele ------------------------------------------------------------ CYGF_Hsap FQITSEV---------------QS-----------------GRSPR--LSFSSG------ ANPb_Hsap GSRLTLS---------------L-------------------RG------SSYG------ ANPa_Hsap GSRLTLS---------------G-------------------RG------SNYG------ CYGD_Hsap ARSMS------------------------------------------------------- T01A4.1_Cele AQN--------------------------------------------------------- Npr1_Spur ------------------------------------------------------------ Npr2_Spur ------------------------------------------------------------ Gcy3_Spur ------------------------------------------------------------ Npr3_Spur ------------------------------------------------------------ Npr4_Spur ------------------------------------------------------------ Gcy1_Spur ------------------------------------------------------------ Gcy2_Spur ------------------------------------------------------------ Npr5_Spur ------------------------------------------------------------ AqueK220_Aque ------------------------------------------------------------ AqueK221_Aque ------------------------------------------------------------ AqueK222_Aque ------------------------------------------------------------ HSER_Hsap -----------DTIQR------------------LRQCKYDKKR--V-ILKDLKH----- CG10738_Dmel --------------IF------------------TPIGLYKGQL--Y-AIKKVRK----- CG9783_Dmel ----SLAR--HNPAHL------------------DMRARYNGDL--V-QLKEVNING--- Gyc32E_Dmel ------------KRSF------------------TNIALFRGNI--V-AMKKIHK----- Gyc76C_Dmel ----QSYGSRWTNQFV------------------TSTGRLRGAV--V-RIKELKFP---- CG4224_Dmel --------------IF------------------IPVGMFRKSK--V-AIKPVEVD---N CG3216_Dmel -------------QVY------------------TTIGQFKGER--V-AIKKVNV----- KSGC_Mmus --------HQDEELFF------------------APVGLYQGNQ--V-ALCYIGDEA--- HSER_Mmus -----------DTIQR------------------VRQCKYDKKK--V-ILKDLKH----- CYGX_Mmus ----SARSLP-AFLEH------------------TNVALYQGEW--V-WLKKFEAGV--- CYGF_Mmus ----SLT--P-ATYEN------------------SNIAIYEGDW--V-WLKKFPPGDFGD CYGD_Mmus ----DIRSVPSQPQES------------------TNVGLYEGDW--V-WLKKFPGEH--- ANPb_Mmus ----SLMTAHGKYQIF------------------ANTGHFKGNV--V-AIKHVNK----- ANPa_Mmus ----SLLTTEGQFQVF------------------AKTAYYKGNL--V-AVKRVNR----- odr-1_Cele ---------------------------------------QRAE-----YVQFKQI----- gcy-9_Cele ------------------------------------QAVSNGVK--L-AIKRYQ-Q---V gcy-8_Cele ---------------------------------------NTHA----IYHKYVQR----- gcy-7_Cele RTTVSFKTESRNFLFF------------------SLQRESDYEP--V-VAKKHA-Y---R gcy-6_Cele -----------------------------------------MER--V-AAKKHS-I---R gcy-5_Cele -----------------------------------------KDL--V-LTTKHH------ gcy-4_Cele -----------------------------------------NDL--V-LTTAHQ------ gcy-3_Cele -----------------------------------------KDM--V-LTMKFQ------ gcy-27_Cele ---------------------------------------QRAE-----FIQFRQI----- gcy-25_Cele -------------------------------------------K--V-SVKRHV-Q---R gcy-23_Cele ---------------------------------------NTHA----SFHLYPQR----- gcy-22_Cele -----------------------------------------NDS--V-VARKHN-F---- gcy-21_Cele ------------------------------------------RT--V-ALKRIYR----- gcy-20_Cele -----------------------------------------QEV--V-AAKKHD-L---- gcy-2_Cele -----------------------------------------KEM--V-LTAKYQ------ gcy-19_Cele -----------------------------------------KEP--V-LSTAHP------ gcy-18_Cele ---------------------------------------NTHT----TYHRYKQR----- gcy-17_Cele -----------------------------------------LKVRQI-GVLTPT-S---M gcy-15_Cele ------------------------------------------RT--V-ALKRIYR----- gcy-14_Cele -----------------------------------------QDI--L-AAMKHD-L---- gcy-13_Cele -----------------------------------------NEP--V-LARKYQ-L---- gcy-12_Cele ----SLMQ--SDVMQFAKTKTPWWSKAPVQGTGMRGLASYKGTL--V-GLKDLMYG---R gcy-11_Cele ----------------------------------------ENTL--V-TVRKIN-----K gcy-1_Cele -----------------------------------------KEM--V-LTAKYQ------ daf-11_Cele -----LAR--T-----------------------KHIATVDQVY--VLADKYVMR----- C04H5.4_Cele ------------------------------------------------------------ CYGF_Hsap ----SLT--P-ATYEN------------------SNIAIYEGDW--V-WLKKFSLGDFGD ANPb_Hsap ----SLMTAHGKYQIF------------------ANTGHFKGNV--V-AIKHVNK----- ANPa_Hsap ----SLLTTEGQFQVF------------------AKTAYYKGNL--V-AVKRVNR----- CYGD_Hsap ----DIRSGPSQHLDS------------------PNIGVYEGDR--V-WLKKFPGDQ--- T01A4.1_Cele -----------NTQIY------------------TKTAIFKGVV--V-AIKKLNIDPKKY Npr1_Spur -----------------------------------------GNV--I-AIKRVNR----- Npr2_Spur -----------------------------------------GRL--V-VIRRIEK----- Gcy3_Spur -------------------------------------------L--V-AIKKIHK----- Npr3_Spur ------------------------------------------------------------ Npr4_Spur ----------------------------------------NGQT--V-AVKMIAK----- Gcy1_Spur ------------------------------------------------------------ Gcy2_Spur ------------------------------------------------------------ Npr5_Spur ------------------------------------------------------------ AqueK220_Aque ------------------------------------------------------------ AqueK221_Aque ------------------------------------------KI--V-KVHKMK-M---- AqueK222_Aque -----------------------------------------GKT--V-AIKKLNYR---S HSER_Hsap NDG-NFTEKQKIELNKL-LQIDYYNLTKFYGTVKLD----------TMIF-GVIEYCERG CG10738_Dmel KSV-DITREMKKELKLL-RDARHDNICAFIGACTDP----------PNIC-IISEYCTRG CG9783_Dmel -SA-ELRTKAMDLLVMA-HGLRHENINPLIGWLSDP----------NRTA-MVFDYCSRG Gyc32E_Dmel KSV-DITRSIRKELKLM-REVRHENIINFIGASTDH----------GSVI-IFTTYCARG Gyc76C_Dmel RKR-DISREIMKEMRLL-RELRHDNINSFIGASVEP----------TRIL-LVTDYCAKG CG4224_Dmel VQG-LLTRSLMLELKRM-KDLQHDHLVKFYGACLDQ----------RRSF-LLTEYCPKG CG3216_Dmel KKV-DLTPQLLWEIKQA-RDVSHENTVRFVGACIDLP--------RPTVL-ILTEYCSRG KSGC_Mmus EAW-VKKPTVRREVCLM-CELKHENIVPFFGVCTEP----------PNIC-IVTQYCKKG HSER_Mmus SDG-NFSEKQKIDLNKL-LQSDYYNLTKFYGTVKLD----------TRIF-GVVEYCERG CYGX_Mmus -AP-DLRPSSLSFLRKL-REMRHENVTAFLGLFVGP----------GVSA-MVLEHCARG CYGF_Mmus -IK-SIKSSASDVFEMM-KDLRHENVNPLLGFFYDS----------GMFA-IVSEFCSRR CYGD_Mmus -HM-AIRPATKTAFSKL-RELRHENVALYLGLFLAGTADSPATPGEGILA-VVSEHCARG ANPb_Mmus KRI-ELTRQVLFELKHM-RDVQFNHLTRFIGACIDP----------PNIC-IVTEYCPRG ANPa_Mmus KRI-ELTRKVLFELKHM-RDVQNEHLTRFVGACTDP----------PNIC-ILTEYCPRG odr-1_Cele RKI-NFPETTLDYLYSL-KQLQHDNLAKFYGIQVNDD--------IMTMT-ILHTLVERG gcy-9_Cele RNI-TFPKSELRLLKEL-KICENDNLNKFYGISFNQQ---------NEFI-VMWVLCSRG gcy-8_Cele RPI-VFNRAD------K-TLIxHDNINPFLGMVWNER---------EEML-LVWKFCSRG gcy-7_Cele PRLD-D--DKCTFMRSL-RNLDQDNLNRFIGLCLDG----------PQML-SVWRFCSRG gcy-6_Cele MVFDNKTCATMRQVVEM-RLIDHANLNKFIGMSLDA----------PQLY-SVWRFCSRG gcy-5_Cele -SM-QMNKEEKEKFVKL-RKLEHDNLNKFIGLSIDG----------PQFV-AVWKMCSRG gcy-4_Cele -VQ-ELSQAEMMKFVKL-RKLDHENLNKFIGLSIDG----------SRFV-SVWKMCSRG gcy-3_Cele -YM-NLNKADMDKFVKL-RKLDHENLNKFIGLSIDS----------SQFI-SVTKLCSRG gcy-27_Cele KHI-DITNASLDFLYNL-KQLKHDNLANFYGIQLNDD--------LNTMT-ILHALVERG gcy-25_Cele RAI-TFSRQEMEMLNQL-KYMSHTNINPFTGICFNQG---------SELI-VMWQFTTRY gcy-23_Cele RPI-VFNRQDLQLLNQM-KQAVHDNLNPFLGMSFNEK---------EEMV-VLWKFCSRG gcy-22_Cele -RA-TFTKNDRAMFRKM-RNVDNDNLCKFIGLSLDS----------PTLI-SIWRYCSRG gcy-21_Cele SDV-EFTRSIRLEIAKL-QESVNSNVIEFVGMVVQSP----------DVF-VVYELAQRG gcy-20_Cele -LV-LFDANQKSEFRQM-RNFDNDNLNKFIGLCLDG----------PQLL-SLWRFCSRG gcy-2_Cele -YT-HLTKADKERFVKM-RKLDHENINRFIGLSIDS----------AHFI-AVTKLCSRG gcy-19_Cele -AS-NLIRTDYDTFVRL-RKLDHENVNKFVGMSIDG----------PEYL-AVWKLCMRG gcy-18_Cele RPI-KFIKEDMQLLTQM-KQAVHDNLNPFLGAAFNEK---------EEML-VLWKFCSRG gcy-17_Cele PYL-KPKLSYFSSMHHM-RSLDHDNLNKFIGLCLNS----------QQLL-SIWRYCSRG gcy-15_Cele SDV-EFTRSNRLEIAKL-QESVNSNVIEFVGMVVQSP----------DVF-VVYELAQRG gcy-14_Cele -IL-QFDAEQKAEFRQM-RNFDNDNLNKFIGLCLDG----------PQLF-SLWRFCSRG gcy-13_Cele -RV-PIFKQDRSELRML-RSIEHDNVNRFIGLSIDG----------PVYM-SFWRYCSRG gcy-12_Cele KPK-DLTREAKKELRAM-RQLAHPNVNNFLGIIVCQ----------YSVT-VVREYCSKG gcy-11_Cele TQL-KLTREMKQEIDLL-MNETHENLNRFFGLINES----------DLIF-TIHSYGPRK gcy-1_Cele -YT-HLTKADKERFVKM-RKLDHENINRFIGLSIDS----------AHFI-SVTKLCSRG daf-11_Cele DKL-RYDKIDINLLYQMKSHLQHDNLNSFVGITIDKA---------SHMY-IIWNQCFRG C04H5.4_Cele ------------------KQAVHDNINPFIGVSFNEK---------SELL-LLWKFCSRG CYGF_Hsap -LK-SIKSRASDVFEMM-KDLRHENINPLLGFFYDS----------GMFA-IVTEFCSRG ANPb_Hsap KRI-ELTRQVLFELKHM-RDVQFNHLTRFIGACIDP----------PNIC-IVTEYCPRG ANPa_Hsap KRI-ELTRKVLFELKHM-RDVQNEHLTRFVGACTDP----------PNIC-ILTEYCPRG CYGD_Hsap -HI-AIRPATKTAFSKL-QELRHENVALYLGLFLARGAEGPAALWEGNLA-VVSEHCTRG T01A4.1_Cele PRL-DLSRAQLMELKKM-KDLQHDHITRFTGACIDF----------PHYC-VVTEYCPKG Npr1_Spur QRV-ELNRNVLMEIKHV-RDLQHDHVIKFIGACIDA----------PNIS-IMTEYCPKG Npr2_Spur TKL-DLTREVLKELNYM-RQVEHNNLVRFVGACVDA----------PNIS-IISEYCPKG Gcy3_Spur RHV-DLTRSVRKELKII-RDLRHPHLNQFIGACVDP----------PNIC-TITEYCPKG Npr3_Spur ----------------M-RNLEHTNVVRFVGACVDP----------PDQA-ILTEYCPRG Npr4_Spur NSF-TLDKRIRKEVKQV-RDLQHSNLCKFAGGCIEVP----------NVS-IITEYCPKG Gcy1_Spur -------RAVRTELKIM-RDMRHDNICPFIGACIDR----------PHIS-ILMHYCAKG Gcy2_Spur ------------------------------------------------------------ Npr5_Spur -------KAIKRELKEM-RWLVHDNINRFLGLCFPST-------SGDMFY-HVSEFSPKG AqueK220_Aque ------------KILTI-LDFKHDNICPFVGGILQG----------SLITGLMYEYCTRG AqueK221_Aque NIS-TLDLNLRKTMLQI-LNFDHENICPFIGCILQG----------PTIVGMMHEYCSHG AqueK222_Aque REL-QLTKTLRKEVMQI-RSLDHANVCRFIGATLRSS---------ENVI-ILTEYCPKG HSER_Hsap SLREVLNDTISYPDGTF--MDWEFKISVLYDIA-------KGMSYLHS-SKTEVHGRLKS CG10738_Dmel SLKDILEN-----EDVK--LDNMFIASMVADII-------RGVIYLHD-SPIRFHGALCT CG9783_Dmel SLQDVLIM-----DEIK--LDWSFRLSLLTDLV-------RGMRYLHT-SPLRVHGALTS Gyc32E_Dmel SLEDVLAN-----EDLH--LDHMFISSLVSDIL-------KGMIYLHD-SEIISHGNLRS Gyc76C_Dmel SLYDIIEN-----EDIK--LDDLFIASLIHDLI-------KGMIYIHN-SQLVYHGNLKS CG4224_Dmel SLQDILEN-----EQFQ--LDWMFRLSLMHDIV-------RGMQFLHS-SDIRSHGNLKS CG3216_Dmel SLKDVLEN-----EAIE--LDWNFRMSLIHDIV-------KGMNYLHN-SDVAAHGKLRS KSGC_Mmus SLQDVMRN-----SDHE--IDWIFKLSFAYDIV-------NGLLFLHG-SPLRSHGNLKP HSER_Mmus SLREVLNDTISYPDGTF--MDWEFKISVLNDIA-------KGMSYLHS-SKIEVHGRLKS CYGX_Mmus SLEDLLQN-----ENLR--LDWTFKASLLLDLI-------RGLRYLHH-RRF-PHGRLKS CYGF_Mmus SLEDILTN-----DDVK--LDWMFKSSLLLDLI-------KGMKYLHH-REF-IHGRLKS CYGD_Mmus SLHDLLAQ-----REIK--LDWMFKSSLLLDLI-------KGMRYLHH-RGV-AHGRLKS ANPb_Mmus SLQDILEN-----DSIN--LDWMFRYSLINDLV-------KGMAFLHN-SIISSHGSLKS ANPa_Mmus SLQDILEN-----ESIT--LDWMFRYSLTNDIV-------KGMLFLHN-GAIGSHGNLKS odr-1_Cele TLEEFCLD-----RDFG--MDDTFKSAFMRDIL-------KGLQYLHK-SSIGYHGHLQA gcy-9_Cele SLEDILFN-----DELK--LGRNFQVSFAKDVV-------KGLNFLHT-SPLLHHGMLCL gcy-8_Cele TLQDIIYN-----ESIQ--LDTKFHGAFIRDIL-------AGLEYLHA-SQIGYHGSLTP gcy-7_Cele SIADVILK-----ATIQ--MDNFFIYSLIKDMV-------HGLVFLHG-SMVGYHGMLTS gcy-6_Cele SLADVIRK-----ASMQ--MDGFFIYSLMKDII-------NGLTWIHE-SSHEFHGMLTS gcy-5_Cele SLQDIIAR-----GNFS--MDGFFMFCIITDIA-------EGMNFLHK-SFLHLHGNLRS gcy-4_Cele SLQDIISK-----GSFS--MDYFFMFCMIRDIA-------EGLHYIHK-SFLRHHGNLRS gcy-3_Cele SLLDILYK-----GNFS--MDFFFMYCIIKDVA-------EGMSYLHK-SFLRLHGNLRS gcy-27_Cele TLEEFCLD-----RDFG--MDETFKSAFMRDIL-------KGLQYLHL-SPVAYHGHLHA gcy-25_Cele SLEDLIFV-----KEQK--FGRNFQSTFIKHIV-------HGINYIHN-SSIKVHGALYL gcy-23_Cele TIQDMIYN-----QEVS--LDSKFHGAFIRDIT-------LGLEYLHS-SIIGYHGSLTP gcy-22_Cele SLQDVIAK-----GSLQ--MDWFFKYSLMRDVA-------DAIYYLHH-SPIGPHGWLSS gcy-21_Cele SLKDILDN-----DDMP--LDDVFRSQMTKDII-------AGLEYLHS-SPIGCHGRLKS gcy-20_Cele SLSDVISK-----SSMQ--MDSFFMFSLIRDIS-------NGLYFIHS-SFLKCHGQLTS gcy-2_Cele SLQDILSR-----GNFS--MDYFFMFCIIRDVA-------KGLEYLHK-TFLRLHGNLRS gcy-19_Cele SLQDIIGQ-----GNFS--IDPFFMFCVIRDMA-------EGLKYLHN-SFLHVHANLRS gcy-18_Cele TIQDIIYN-----ANVV--LDEKFHGAFVRDIT-------LGLEYLHA-SPIGYHGSLTP gcy-17_Cele SLADVISR-----SSMQ--MDSFFMLSLIRDIA-------NGLGFIHT-SMLHFHGYLSS gcy-15_Cele SLKDILDN-----DDMP--LDDVFRSQMTKDII-------AGLEYLHS-SPVGCHGRLKS gcy-14_Cele SLSDVISK-----SSMQ--MDSFFMFSLIRDIS-------NGLLFIHN-SFLKCHGHLTS gcy-13_Cele SIKDVIAK-----SSIN--MDGFFIYCLIKDIASVSRHENPGLQYIHH-SPIKQHGSLTS gcy-12_Cele SLHDILRN-----ENLK--LDHMYVASFVDDLV-------KGMVYIHD-SELKMHGNLKS gcy-11_Cele SLMDLLRN-----DDLR--LDRMFKVSFVEDVV-------KGLQFLHEGSKIGYHGNLKS gcy-1_Cele SLQDILSR-----GNFS--MDYFFMFCIIRDVA-------KGLEYLHK-TFLRLHGNLRS daf-11_Cele SLHDHIFT-----KERQRGTATRFEGLFLRDIL-------KGLEYIHA-SAIDFHGNLTL C04H5.4_Cele TLQDVIYC-----EKFA--MDEKFQGAFVRDIT-------MGLEYLHS-SPIGYHGGLAC CYGF_Hsap SLEDILTN-----QDVK--LDWMFKSSLLLDLI-------KGMKYLHH-REF-VHGRLKS ANPb_Hsap SLQDILEN-----DSIN--LDWMFRYSLINDLV-------KGMAFLHN-SIISSHGSLKS ANPa_Hsap SLQDILEN-----ESIT--LDWMFRYSLTNDIV-------KGMLFLHN-GAICSHGNLKS CYGD_Hsap SLQDLLAQ-----REIK--LDWMFKSSLLLDLI-------KGIRYLHH-RGV-AHGRLKS T01A4.1_Cele SLEDILEN-----EKIE--LDKLMKYSLLHDLV-------KGLFFLHN-SEIRSHGRLKS Npr1_Spur SLQDILEN-----DSIE--LDELFKYSLMYDIV-------KGMLYLHN-SVIQTHGNLKS Npr2_Spur SLQDIVEN-----DALK--LDNMFKNSLITDVM-------RGLHYLHS-SVIMLHSRLSS Gcy3_Spur SLQDILEN-----DEVK--LDSMFIASLIGDIL-------KGLSCLHA-SETHSHGNLKS Npr3_Spur SLQDILEN-----DQLK--LDLMFRQSLLMDAV-------RGLNYIHD-SVIGVHGRLTS Npr4_Spur ALSDVLLN-----EDVP--LNWSFRFSFCMDVA-------RGMHYMHN-NKL-YHGKLTS Gcy1_Spur SLQDILEN-----DDIK--LDSMFLSSLIADLV-------KGIVYLHS-SEIKSHGHLKS Gcy2_Spur ---DILEN-----DDIK--LDEMFIASLVSDIV-------KGMRHLHS-TEIRTHGNLKS Npr5_Spur SLKSILAN-----DDVN--LDLSFKASFIRDLA-------RGMQFLHA-SEIKNHGVLSS AqueK220_Aque SLYDLLTN-----PHIG--FNKSFRQSFAIDCS-------EGLAYLHG-RKA-IHGRLTS AqueK221_Aque SLYEVLRN-----PNIV--FDKQFRVLFATDII-------KGLTYLHS-HKL-THGRLSS AqueK222_Aque SLNDVLQN-----DDIP--LNWGFRFSFVTDIS-------RGLAYLHS-KRI-VHHRLMS . . . .: :* * * HSER_Hsap TNCVVDSRMVVKITDFGCNSILP------------------------------------- CG10738_Dmel SNCLVDSRWVVKLTDFGLFAFKQGIEDSST-------------------------D---M CG9783_Dmel RNCVVDARWVLKITDYGLNSFYESQGLP-P------------------------------ Gyc32E_Dmel SNCLIDSRWVCQISDFGLHELKAGQEEPNK------------------------------ Gyc76C_Dmel SNCVVTSRWMLQVTDFGLHELRQCAENES------------------------------I CG4224_Dmel SNCVVDSRFVLKITDFGLHTLRRTRFDLES-------------------------DGGNC CG3216_Dmel CNCLIDGRFVLKISDFGLRTLTTPSDFV-R------------------------------ KSGC_Mmus SNCLVDSHMQLKLSGFGLWEFKHGSTWRS--------------------------Y---N HSER_Mmus TNCVVDSRMVVKITDFGCNSILP------------------------------------- CYGX_Mmus RNCVVDTRFVLKITDHGYAEFLESHCSS-R------------------------------ CYGF_Mmus RNCVVDGRFVLKVTDYGFNDILEMLRLS-E------------------------------ CYGD_Mmus RNCVVDGRFVLKVTDHGHGRLLEAQRVL-P------------------------------ ANPb_Mmus SNCVVDSRFVLKITDYGLASFRSTAEPD-D------------------------------ ANPa_Mmus SNCVVDGRFVLKITDYGLESFRDPE-PE-Q------------------------------ odr-1_Cele STCLIDINWVLKLTLYGVSNFMSDQLDAEN-----I---------------K-VPE---Q gcy-9_Cele QNCLVDSNWTVKLTNFATEAVIFEKLDHNE-----LRP-----FINTDSESADDVS---D gcy-8_Cele WSCLIDRNWMIKLTDYGIADPLERWEKSQSISRDGL---------------T-SDD---D gcy-7_Cele KCCLIDDRWQVKISNYGLQDLRSPE----------------------------------- gcy-6_Cele KNCLLNDRWQLKITDFGLRIFRTHD----------------------------------- gcy-5_Cele ATCLVNDSWQVKLTDFGLGALLEEH----------------------------------- gcy-4_Cele ATCLVNDSWQVKLADFGLQFLQDEEE---------------------------------- gcy-3_Cele ATCLVNDSWQVKLAEFGFDQLLEEI----------------------------------- gcy-27_Cele ATCLIDINWVLKIALYGVTNFVCDNFDAEN-----I---------------T-MPD---R gcy-25_Cele SNCVVDSYWVVKLTDFGIKGILKERTNHKE-----L---------------APS-S---A gcy-23_Cele WSCLIDRNWMIKLTDYGIANPLERWEKLGLISTETL---------------K-EGD---D gcy-22_Cele STCLVDERWQVKVSFFGLSAIKQYE----------------------------------- gcy-21_Cele TNCLIDARWMVRLSSFGLRELRGEETWQQE------------------------------ gcy-20_Cele RCCLIDDRWQIKISGFGLKSVRTFE----------------------------------- gcy-2_Cele ATCLVNDSWQVKLAEYGMDNLVEEQ----------------------------------- gcy-19_Cele GTVLVNESWQAKLTDFGLGTLAEEK----------------------------------- gcy-18_Cele WCCLIDRNWMVKLSDYGIANPLERWEKQGAIEIAAA---------------K-DSD---D gcy-17_Cele RSCLIDDRWQVKISDFGLNEVRGMD----------------------------------- gcy-15_Cele TNCLIDARWMVRLSSFGLRELRGEETWQQE------------------------------ gcy-14_Cele RCCLIDDRWQIKISGYGLKSVRTFE----------------------------------- gcy-13_Cele ECCYINDRWQVKIGSYGLSFMQGVE----------------------------------- gcy-12_Cele TNCLITSRWTLQIADFGLRELREGIMYDSS------------------------------ gcy-11_Cele SNCIVDAYWRIKLSNYGMEQIRVEEPESKP-----DVFYDLVIF--SNKYN-SKTK---N gcy-1_Cele ATCLVNDSWQVKLAEYGMDNLVEEQ----------------------------------- daf-11_Cele HNCMLDSHWIVKLSGFGVNRLLVKWKTSGQ-----I---------------F--TE---- C04H5.4_Cele WSVLIDKNWMLKLTDYAVCDPLKRWEKHGRIN---C---------------K-VDN---E CYGF_Hsap RNCVVDGRFVLKVTDYGFNDILEMLRLS-E------------------------------ ANPb_Hsap SNCVVDSRFVLKITDYGLASFRSTAEPD-D------------------------------ ANPa_Hsap SNCVVDGRFVLKITDYGLESFRDLD-PE-Q------------------------------ CYGD_Hsap RNCIVDGRFVLKITDHGHGRLLEAQKVL-P------------------------------ T01A4.1_Cele SNCVVDSRFVLKVTDFGLHRLHCLEEINLE-------------------------E---I Npr1_Spur SNCVVDSRFVLKITDFGLTSFREPD-PS-S------------------------------ Npr2_Spur SNCVVDSRFVLKLTDYGLTKFRDTDSNE-R------------------------------ Gcy3_Spur SNLVVDSRWVLKITDFGLHQFRSGSRPPE------------------------------I Npr3_Spur SNCVVDGRFVLKITDFGIPSFRNSNKYE-------------------------------- Npr4_Spur SNCVVDDRWVVKIADYGLTTFRNQEGSQ-S-------------------------N---A Gcy1_Spur SNCVVDNRWVLQITDYGLNEFKKGQKQD-V-------------------------D---L Gcy2_Spur SNCVVDSRWVLKITDFGLVHFKVGQQPPD------------------------------M Npr5_Spur STCYVDSRWVLKISGFGLLSFNILKEDVMK-------------------------Q---- AqueK220_Aque NNCVIDQHWNLKLT---------------------------------------------- AqueK221_Aque VTCVIGNLWKLKLTDY-------------------------------------------- AqueK222_Aque TNCVIDDRWVVKITDYG------------------------------------------- : :: HSER_Hsap --------PKKDLWTAPEHLR----------QAN-----------------ISQKGDVYS CG10738_Dmel QHMS--AKCLKLLYRAPELLR----------QGPS------------SLVMGTQRGDAYS CG9783_Dmel R--T--RSAKELLWTAPELLR----------NMKLH----QHHHQHGRIQLGTQLGDVYS Gyc32E_Dmel S--E--LELKRALCMAPELLR----------DAYR-------------PGRGSQKGDVYS Gyc76C_Dmel -GEH--QHYRNQLWRAPELLR----------NHI----------------HGSQKGDVYA CG4224_Dmel N-SH--AYWSKLLWTAPELLR----------VEHN------------RPPEGTQKGDVYA CG3216_Dmel D--Q--NYYLKLLWIAPELLP----------LTTIP-----------GCCPATQRGDVYS KSGC_Mmus Q-EA--TDHSELYWTAPELLR----------LRES-------------PCSGTPQGDVYS HSER_Mmus --------PKKDLWTAPEHLR----------QAT-----------------ISQKGDVYS CYGX_Mmus P--Q--PAPEELLWTAPELLR----------GPG----------------KATFKGDVFS CYGF_Mmus E--E--PSEEELLWTAPELLR----------APGGI-------------RLGSFAGDVYS CYGD_Mmus E--P--PSAEDQLWTAPELLR----------DPSLE-------------RRGTLAGDVFS ANPb_Mmus S-H---ALYAKKLWTAPELLS----------GNP-------------LPTTGMQKADVYS ANPa_Mmus G-H---TLFAKKLWTAPELLR----------MAS-------------PPARGSQAGDVYS odr-1_Cele AAHM--ITYPQYVCFPPEHIR----------EYDDSGK--Q----PPRVVRGSPKGDIYC gcy-9_Cele PTKD--FARKKYLQQAPEIIR----------EIVTTKT----------IPEGSQSADIYA gcy-8_Cele KSQA--TQATSILYESPEMLK----------NREKNRVRRVDQDWMRQTQTRRQLGDVYA gcy-7_Cele ---M--YEKKDLLWSAPELLR----------AEDI---------------KGSKEGDVYS gcy-6_Cele ---Q--YNKSDRLWTSPELLR----------TDDI---------------LGSREGDIYS gcy-5_Cele ---T--PSKKRLLWAAPEVLR----------GSLT-------------IHQMDPSADVYS gcy-4_Cele ---K--PFKKNMLWAAPEVIR----------GSLS-------------IEQMDSSADIYS gcy-3_Cele ---T--PTKRRLLWAAPEVLR----------GSLT-------------VSQMDPSADVFS gcy-27_Cele SDYT--ISYAQYVCFPPEHIR----------EYDATGK--L----PTRFVRGSKQGDIYC gcy-25_Cele FDVD--AIHYKYLQLAPEHIS----------AILEKLE----------EPRGTVEGDIYQ gcy-23_Cele KSGS--AQKTSLLYQPPEMLK----------NKESNRTRRMDQSWVKQSQARRQMGDIYA gcy-22_Cele ---V--KEQRDFLHTAPEHIR----------DTNL---------------PITKEMDIYS gcy-21_Cele -DDV--QEGKDQLWTSPELLR----------WSTGLSQ---------CGVLLVQKSDVYS gcy-20_Cele ---N--PKKEDLLWASPEYLR----------NEDQ---------------ERLPEGDIYS gcy-2_Cele ---T--PPKKRLLWVAPEVLR----------GSLS-------------VSQMEPSADIYS gcy-19_Cele ---K--PMKRRQLWMAPEVIR----------GTLL-------------PHQIEKSADIYS gcy-18_Cele KSQA--SQATSIIYMAPELLK----------NRETNKRRGMDQSWVKQSMLRRQAGDIYS gcy-17_Cele ---K--LSTENMLWWAPEVLR----------GLE----------------QRSKEADIYS gcy-15_Cele -DDV--QEGKDQLWTSPELLR----------WSTGLSQ---------CGVLLVQKSDVYS gcy-14_Cele ---N--PKKEDLLWTPPENLR----------NENE---------------ERLPEGDIYS gcy-13_Cele ---K--RTEDGLLHTAPEVLR----------EGLT---------------SGTQAGDVYS gcy-12_Cele ---Y--NIWENFLWTAPEAMT----------INGSL-A---------ISNPPTPKADAYS gcy-11_Cele P-IK--KFSTDLLWFAPEIIR----------RYAVKHD---------LSKLELAKADIYS gcy-1_Cele ---T--PPKKRLLWVAPEVLR----------GSLS-------------VSQMEPSADIYS daf-11_Cele -DHTPVIKSEELHYFDPAMKKIWKNYADRNERALITPQ-------------FGKKCDMYS C04H5.4_Cele AEKQ--WQKMASLYVPPEIRT----------ANEKNRLKRMDQKWQGQTILKRQQSDIYA CYGF_Hsap E--E--SSMEELLWTAPELLR----------APRGS-------------RLGSFAGDVYS ANPb_Hsap S-H---ALYAKKLWTAPELLS----------GNP-------------LPTTGMQKADVYS ANPa_Hsap G-H---TVYAKKLWTAPELLR----------MAS-------------PPVRGSQAGDVYS CYGD_Hsap E--P--PRAEDQLWTAPELLR----------DPALE-------------RRGTLAGDVFS T01A4.1_Cele G-EH--AYYKKMLWTAPELLR----------DSN-------------APPMGTQKGDIYS Npr1_Spur --S---TYFAGRLWTAPELLR----------LPE-------------IPSGGTQKGDVYS Npr2_Spur Q-TS--KNEQKMLWQAPETLR----------SAN-------------Q--QPTQKGDIYS Gcy3_Spur -GEH--AKYEKLLWRAPELLR----------DPAP-------------RPEGTQKGDMYS Npr3_Spur ---D---NNYKLLWRAPERLR----------DPF-------------S--PPSKEGDLYA Npr4_Spur G-GY--RSKAMQVYLPPENRS----------NTY---------------TLVTQATDVYS Gcy1_Spur -GDH--AKLARQLWTSPEHLR----------QEGS------------MPTAGSPQGDIYS Gcy2_Spur -GEH--AYYQDLLWKAPEVWE----------------------------PQGTQKGDVYS Npr5_Spur KDPE--VKFSKMLWTAPEHLR----------GEML-------------PSKGSQKGDVYS AqueK220_Aque ------------------------------------------------------------ AqueK221_Aque ------------------------------------------------------------ AqueK222_Aque ------------------------------------------------------------ HSER_Hsap YGIIAQEIILRKETFYTLS--CR-D-------------RN-EKIFR--V-ENS----NGM CG10738_Dmel FGILLYEMHVRRGPFGETG----LT-------------PM-QCLQK--V-LQPQD---YL CG9783_Dmel FGIIMQEVVVRGEPYCMLS----LS-------------PE-EIIVK--I-KK-----P-P Gyc32E_Dmel FGILLYEMIGRKGPWGDTA----YS-------------KE-EIIQF--V-KCPEM--LQH Gyc76C_Dmel FAIIMYEIFSRKGPFGQIN----FE-------------PK-EIVDY--V-KKLPL--KGE CG4224_Dmel FGIIVHEITTRQGPFYLGRCAYEKS-------------PQ-EIIEL--V-KGYNP-HRMQ CG3216_Dmel FGIILEEIVNRGGPYQEAR--QQMD-------------VH-TILHK--V-RQ-------C KSGC_Mmus FAILLRDLIHQQAHGPFED--LEAA-------------PE-EIISR--I-KDPR----AP HSER_Mmus FAIIAQEIILRKETFYTLS--CR-D-------------HN-EKIFR--V-EN-----SYG CYGX_Mmus LAIILQEVLTRDPPYCSWG----LS-------------AE-EIIRK--V-AS-----P-P CYGF_Mmus FAIIMQEVMVRGAPFCMMD----LP-------------AK-EIIDR--L-KM-----P-P CYGD_Mmus LAIIMQEVVCRSTPYAMLE----LT-------------PE-EVIQR--V-RS-----P-P ANPb_Mmus FAIILQEIALRSGPFYLEG--LDLS-------------PK-EIVQK--V-RN-----GQR ANPa_Mmus FGIILQEIALRSGVFYVEG--LDLS-------------PK-EIIER--V-TR-----GEQ odr-1_Cele VGMIFYMMVEREDPYHLIH--SVER-------------PNATLIKQ--I-LN-----E-- gcy-9_Cele LGMVLYQILFRVEPFHERN--KSIN----------------KLMET--L-AMAN---DDD gcy-8_Cele FGLVMYEIIFRALPFPEG---TN---------------QS-ELVEW--L-RD------GS gcy-7_Cele LGIICAELITRKGVFNMED--RKED-------------PE-EIIYL--L-KK-----GGL gcy-6_Cele FGIISAELITRSSVFDLEN--RKED-------------AE-EIIYM--L-KK-----GGL gcy-5_Cele FAIIASEILTKREAWDISN--RKEG-------------AD-EILYM--V-KK-----GGN gcy-4_Cele FAIVASEILTKREAWDLSR--R----------------KE-EIKYA--V-KK-----GGQ gcy-3_Cele FAIIASEILTRKEAWDLKE--RKEG-------------YD-EIIYR--V-KK-----GGS gcy-27_Cele VGMIFYMMIEREDPYRLIH--SVER-------------PGSGLMME--I-LD-----H-- gcy-25_Cele LAMCIYQILFYMRPFAERQ--ESIKVY----SGEIFLKLP-ELAHL--L-S--S---QST gcy-23_Cele FGMVMHEILFRALPFPNG---TN---------------VS-EVMDY--I-RD------GT gcy-22_Cele FAIICSELITKKSAWDLEN--ETFD-------------IE-ELVYK--I-KK-----GGR gcy-21_Cele LAIVLYELFGRLGPWGDEP--ME---------------PR-EIVSL--V-KRE--ALAGK gcy-20_Cele FGIICAEILTRSSAFDLEN--RKEK-------------PD-VIIYQ--V-KK-----GGH gcy-2_Cele FAIIASEILTKKEAWDILD--RKED----------------------------------- gcy-19_Cele LAVIASEVLTRKEAWNMAE--RKDT-------------VD-EIVYR--I-KK-----GGP gcy-18_Cele FGMVMYEILFRSLPFRDN---TN---------------IS-ELVDY--L-AD------GS gcy-17_Cele FGIICSEVITRSSAFDLEN--RKEK-------------PE-EIIYQ--L-KK-----GGF gcy-15_Cele LAIVLYELFGRLGPWGDEP--ME---------------PR-EIVSL--V-KRE--ALAGK gcy-14_Cele FGIICSEILTRSSAFDLEN--RKEK-------------PD-VIIYQ--V-KK-----GGH gcy-13_Cele FSIVCSELVGHSSAWNLEN--RKEE-------------AD-EIIFM--V-KR-----GGR gcy-12_Cele FGIIFHEIFTREGPYKIYV--QRGDVNGEAAPKKDSVECR-ALVEK--TVRRV----YSD gcy-11_Cele LAIVLYEIYGRQGPFGDDL--LD---------------SD-EIIEQ--L-KFP----DGG gcy-1_Cele FAIIASEILTKKEAWDILD--RKED-------------CE-EIVYN--V-KK-----GGL daf-11_Cele FGVILHEIILKKKFVEQLF--DS---------------PR-EEDDSVLI-DDENDAIASR C04H5.4_Cele FGVIIYEILFRSLPYDEK---VD---------------LT-ELAQK--A-AE------GD CYGF_Hsap FAIIMQEVMVRGTPFCMMD----LP-------------AQ-EIINR--L-KK-----P-P ANPb_Hsap FGIILQEIALRSGPFYLEG--LDLS-------------PK-EIVQK--V-RN-----GQR ANPa_Hsap FGIILQEIALRSGVFHVEG--LDLS-------------PK-EIIER--V-TR-----GEQ CYGD_Hsap LAIIMQEVVCRSAPYAMLE----LT-------------PE-EVVQR--V-RS-----P-P T01A4.1_Cele FAIILHEMMFRKGVFALEN--EDLS-------------PN-EIVQR--V-RKPVS--EDQ Npr1_Spur FGIILQEIMYREGVFYIKD--VDLM-------------PE-EIVKK--V-AN-----GYK Npr2_Spur VGIIMQEIVTRARPFEEER--SSME-------------ID-EIVKK--L-TE-----TSS Gcy3_Spur LGIILYEMATRQGPYG-------------------------------------------- Npr3_Spur LGIIMLEIGTRCGPFDEER--KVMD-------------TN-GILEI--L-KST----SSQ Npr4_Spur YGVILVEIASRNEVIPEDD--YPL---------------D----------------EAWR Gcy1_Spur FAIILTELYSRQEPFHENE----MD-------------LA-DIIAR--V-KIG-----EV Gcy2_Spur FGIILYEIAHRQGPFGNCE----LS-------------PK-EIYEK--V-KTLG----ET Npr5_Spur FAIILQEIVTRSHPFYLSG--YT---------------SR-EIIRR--V-IR-----RDE AqueK220_Aque ------------------------------------------------------------ AqueK221_Aque ------------------------------------------------------------ AqueK222_Aque ------------------------------------------------------------ HSER_Hsap KPFRPDL-FLET-----A----EEKELEVYLLVKNCWEEDPEKRPDFKKIETTLAK-IFG CG10738_Dmel NPYRPSL-QPLE-----------TAFDCVSECLRECWAERPEDRPD-------------- CG9783_Dmel PLIRPSV-SKG------------AAPPEAINIMRQCWAEQPDMRPDFNSVYE-------- Gyc32E_Dmel GVFRPAL-THTH----------LDIPDYIRKCLCQCWDEDPEVRPDIRLVRMHL------ Gyc76C_Dmel DPFRPEV-ESIIE----A----ESCPDYVLACIRDCWAEDPEERPE-------------- CG4224_Dmel KPFRPEL-EPN-----------GDTKADINGIIRRCWAEDPAERPDFNTLKS-------- CG3216_Dmel NGFRPLI-RER------------ECPPDLLELMEKCWADNQEERPTFSTIRSNIRT-IMK KSGC_Mmus VPLRPSL-LED------------KGDGRIVALVRECWDESPELRPIFPSIKKT------- HSER_Mmus KPFRPDL-FLET-----A----DEKELEVYLLVKSCWEEDPEKRPDFKKIESTLAK-IFG CYGX_Mmus PLCRPLV-SPD------------QGPLECIQLMQLCWEEAPDDRPSLDQIYTQF------ CYGF_Mmus PVYRPVV-SPE------------YAPAECLQLMKQCWAEASEQRPTFDEIFNQF------ CYGD_Mmus PLCRPLV-SMD------------QAPMECIQLMTQCWAEHPELRPSMDLTFD-L------ ANPb_Mmus PYFRPSI-DRT------------QLNEELVLLMERCWAQDPTERPDFGQIKGFI------ ANPa_Mmus PPFRPSM-DLQ------------SHLEELGQLMQRCWAEDPQERPPFQQIRLAL------ odr-1_Cele -NHMPRI-TDDYR----Q-------ENMLLEMCKECWDRNPDKRPTIKKLIES------- gcy-9_Cele QLIRPTF-PSSNT----G----EGYNLQLLSCIEACWLEIPEMRPPIKKVRTMVNANLKS gcy-8_Cele KVVKPTI-PQNKV----L-------NMDLSALIQDCWNTTPEMRPSLRRIKLNV------ gcy-7_Cele KSPRPDL-EYDHT---------IEINPALLHLVRDCFTERPSERPSIETVRSQLRG-MNS gcy-6_Cele QSPRPSL-EHDES---------IEINPALLHLVRDCWTERPSERPDIKQVASQLRS-MNT gcy-5_Cele RTIRPEL-ILD-----------AEVSPRLTTLVKDCWSEQPEDRPKAEQICKLLSE-MTP gcy-4_Cele FVLRPDL-HID-----------IEVNQTLLALVKDCWCENPEERPSAENVCKVLFD-MTP gcy-3_Cele FPIRPDI-ITDV----------PDVNPTLIALVKDCWAEAPEDRPTAENICEQLRD-LMP gcy-27_Cele -NLMPFI-SNNET----Q-------EDTLLDKCKECWNRDPEKRPTIENLRNA------- gcy-25_Cele APLHPKV-PE-------G----NSFTMRLLSIIQQCWLYKPAARPALIKITDAVNREFGQ gcy-23_Cele KTFRPTV-HDRTQ----I-------HPDLVALLLDCWNENPEVRPSIRRVRLNT------ gcy-22_Cele SPPRPSL-ETED-----------EHNGSMSLLVRDCWNENPDQRPTSEQIKTLMKS-MNH gcy-21_Cele KPFRPDM-AVLKE----S-------PRIVQETVVAAWTEDPLNRPSLHQIKR-------- gcy-20_Cele NPTRPSL-DTGET---------VVINPALLHLVRDCWTERPSERPSIEQVRSHLNG-MKD gcy-2_Cele -------------------------CEALIALVKDCWAEVPEDRPTAENICSQMKG-LVS gcy-19_Cele NAPRPEL-DMDG----------VEINHNLLILIRDCWSEEPADRPSADVICNLLKN-MMP gcy-18_Cele KTVSPEI-QNQMG----L-------HPDLNALLRDCWSENPEIRPSIRRVRLN------- gcy-17_Cele NAIRPSL-LTDEA---------LEINPALVHLIRDCWTEKPSERPPIDQVRSLLRG-MND gcy-15_Cele KPFRPDM-AVLKE----S-------PRIVQETVVAAWTEDPLNRPSLHQIKR-------- gcy-14_Cele NPMRPSL-DTGET---------VEINPALLHLIRDCWTERPSERPSIEQVRGHLNG-MRD gcy-13_Cele TPFRPSL-DDVD----------DDINPAMLHLIRDCWDEDPKQRPNIDMVNKLMKN-MNS gcy-12_Cele PYFRPDT-SD-------L-----EVQNYVKEVMAACWHHDPYQRPEFKTIKNKLK----- gcy-11_Cele ALTRPDI-HL-------I----TKAPYPLASVVEKCWVEDPASRPSIQKVREL------- gcy-1_Cele FPIRPEI-ITDI----------HDVNPALIALVKDCWAEVPEDRPTAENICSQMKG-LVS daf-11_Cele FP-LPIIIPEGIE----M-------HNDLIKMLENCFGS---VRPDIALA-R-------- C04H5.4_Cele KIQKPSI-QRNKK----L-------NPDLIALLQGIVF-------------VSL------ CYGF_Hsap PVYRPVV-PPE------------HAPPECLQLMKQCWAEAAEQRPTFDEIFNQF------ ANPb_Hsap PYFRPSI-DRT------------QLNEELVLLMERCWAQDPAERPDFGQIKGFI------ ANPa_Hsap PPFRPSL-ALQ------------SHLEELGLLMQRCWAEDPQERPPFQQIRLTL------ CYGD_Hsap PLCRPLV-SMD------------QAPVECILLMKQCWAEQPELRPSMDHTFD-L------ T01A4.1_Cele EPLRPWV-SETGEGEG-D----DALNDTLLSLMVACWSEDPHERPEVSSVRKAVR----- Npr1_Spur PAFRPTI-DRV------------TCSQEMMTLITNCWKEDSTIRPDYSQLRGT------- Npr2_Spur PPFRPEI-DPQ------------LCTDEIRSIIQACWEEMPENRPATTDLLSS------- Gcy3_Spur ------------------------------------------------------------ Npr3_Spur PPFRPSV-PEA------------VWNPVIKDLMKRCWAENPGDRPTASALQTAL------ Npr4_Spur -PPLPDL-EIGDTTDDER----CPCPADYLSLIERCWNINPAQRPHFSQIRQT------- Gcy1_Spur PPYRPIL-NAVN----------AAAPDCVLSAIRACWPEDPDDRPNIMAVRTMLAP-L-- Gcy2_Spur IPLRPNV-MEIE-----------NGHECLLTVMQECWVEDPEARPDFKTIAN-------- Npr5_Spur PPCRPKI-NEDEF----ETSDMATIFTAIYELMKVCWEELPEDRPDFTAIRA-------- AqueK220_Aque ------------------------------------------------------------ AqueK221_Aque ------------------------------------------------------------ AqueK222_Aque ------------------------------------------------------------ HSER_Hsap LFHD-------QKNES-YM CG10738_Dmel ------------------F CG9783_Dmel -----------------RF Gyc32E_Dmel -----------------KE Gyc76C_Dmel ------------------F CG4224_Dmel ------------------M CG3216_Dmel GFCE-------NLMDD-LL KSGC_Mmus ------------------L HSER_Mmus LFHD-------QKNES-YM CYGX_Mmus -----------------KS CYGF_Mmus -----------------KT CYGD_Mmus -----------------FK ANPb_Mmus -----------------RR ANPa_Mmus -----------------RK odr-1_Cele ---------------I-ST gcy-9_Cele TGKGSLVDQMMKMMEE-YT gcy-8_Cele --------------ET-YL gcy-7_Cele SR-------NDNLMDH-VF gcy-6_Cele NR-------NDNLMDH-VF gcy-5_Cele RG-------NTNLMDH-VF gcy-4_Cele NT-------EDNLMDHVFS gcy-3_Cele KT-------KSNLMDH-VF gcy-27_Cele ---------------I-AI gcy-25_Cele DVKGTLIDQMI-EMID-EY gcy-23_Cele --------------EN-YL gcy-22_Cele NR-------SSNLMDH-VF gcy-21_Cele -----------------KL gcy-20_Cele GR-------KTNLMDH-VF gcy-2_Cele KQ-------KTNLMDH-VF gcy-19_Cele -K-------KGNLMDH-VF gcy-18_Cele ---------------T-EM gcy-17_Cele GK-------KGNLMDH-VF gcy-15_Cele -----------------KL gcy-14_Cele GR-------KSNLMDH-VF gcy-13_Cele GRSG-----SANLMDHVFS gcy-12_Cele ---------------P-LF gcy-11_Cele ------------------L gcy-1_Cele KQ-------KTNLMDH-VF daf-11_Cele -----------------KI C04H5.4_Cele --------------AA-SL CYGF_Hsap -----------------KT ANPb_Hsap -----------------RR ANPa_Hsap -----------------RK CYGD_Hsap -----------------FK T01A4.1_Cele -----------------SL Npr1_Spur ------------------M Npr2_Spur ------------------M Gcy3_Spur ------------------K Npr3_Spur ------------------K Npr4_Spur ------------------L Gcy1_Spur -------------QKG-LK Gcy2_Spur -----------------KL Npr5_Spur -----------------KL AqueK220_Aque ------------------D AqueK221_Aque ------------------G AqueK222_Aque ------------------I