CLUSTAL W (1.83) multiple sequence alignment RIOK3_Hsap_RIO3 HSTAEKAVDPKTRLLMYKMVNSGMLETITGCISTGKESVVFHAYGGSMEDEKEDSKVIPT RIOK2_Hsap_RIO2 YRLTNAGYDY---LALKTLSSRQVVESVGNQMGVGKESDIYIVANEEG-----------Q RIOK1_Hsap_RIO1 RATVEQVLDPRTRMILFKMLTRGIITEINGCISTGKEANVYHASTANG-----------E CG11660_Dmel_RIO1 A----------------------------------------------------------- CG11859_Dmel_RIO2 A----------------------------------------------------------- CG3008_Dmel_RIO3 A----------------------------------------------------------- RIO2_Scer_RIO2 -------------------------YSVGNTIGVGKESDIYKVSDKNG-----------N RIO1_Scer_RIO1 PVID-------------------------------EETGQYEVLETDGS---------RA RIOK1_Mmus_RIO1 RATVEQVLDPRTRMILFKLLHKDHISEIHGCISTGKEANVYYASTPSG-----------E RIOK2_Mmus_RIO2 YRLTNAGYDY---LALKTLSSRQVVESVGNQMGVGKESDIYIVANEAG-----------Q RIOK3_Mmus_RIO3 HSTAEKAVDPKTRLLMYKMVNSGMLETITGCISTGKESVVFHAYGGSLEDEKEDGKAIPT Rio1_Ddis_RIO1 A----------------------------------------------------------- Rio2_Ddis_RIO2 A----------------------------------------------------------- 11147_Tthe_RIO1 --------------------------------------NVYHASSSNG-----------K 27105_Tthe_RIO2 --------------------------------------DIYKCVNENG-----------D CC1G_04984_Ccin_RIO1 -----QVLDPRTRLILFKMIGRGLIHEVNGCVSTGKEANVYHATTPTK-----------D CC1G_13652_Ccin_RIO2 YRLTYGGYDY---LAMRALSKRDSMTSVGNQIGVGKESDIYVVANAEG-----------D GK011_Glam_RIO2 YALTYMGYDY---LSLNVMKRRGVISAIGSRIGVGKEADVYMAMRPNG-----------Q GK010_Glam_RIO1 RATTNLVLDDRVRKLIFRLIEKGALLSVDSVINTGKEANVFLCNSEAG------------ RIOK3_Hsap_RIO3 ECAIKVFKTTLNEF---KNRDKYIKDDFRFKD--RFSKLNPRKIIRMWAEKEMHNLARMQ RIOK2_Hsap_RIO2 QFALKLHRLGRTSFRNLKNKRDYHKH-------R--HNVSWLYLSRLSAMKEFAYMKALY RIOK1_Hsap_RIO1 SRAIKIYKTSILVF---KDRDKYVSGEFRFRH--GYCKGNPRKMVKTWAEKEMRNLIRLN CG11660_Dmel_RIO1 ------------------------------------------------------------ CG11859_Dmel_RIO2 ------------------------------------------------------------ CG3008_Dmel_RIO3 ------------------------------------------------------------ RIO2_Scer_RIO2 PRVMKIHRLGRTSFHSVRNNRDYLKK-------S-NQGANWMHLSRLAANKEYQFMSMLY RIO1_Scer_RIO1 EYAIKIYKTSILVF---KDRERYVDGEFRFRN--SRSQHNPRKMIKIWAEKEFRNLKRIY RIOK1_Mmus_RIO1 SRAIKIYKTSILMF---KDRDKYVTGEFRFRR--GYCKGNPRKMVRTWAEKEMRNLCRLK RIOK2_Mmus_RIO2 QLALKLHRLGRTSFRNLKNKRDYHKH-------R--HNVSWLYLSRLSAMKEFAYMKALY RIOK3_Mmus_RIO3 ECAIKVFKTTLNEF---KNRDKYIKDDFRFKD--RFSKLNPRKIIRMWAEKEMHNLTRMQ Rio1_Ddis_RIO1 ------------------------------------------------------------ Rio2_Ddis_RIO2 ------------------------------------------------------------ 11147_Tthe_RIO1 EYAIKIYKTSILVF---KDREKYVAGEFRFRK--GHCKSNPRKMIKLWAEKEIRNLKRIY 27105_Tthe_RIO2 FVILKFTRLGRTSFRTIKKNRDYIQH-------R--TSYSWLYLSRLSAIKEYTFMDLLH CC1G_04984_Ccin_RIO1 HLALKIYKTSILVF---KDRSKYVTGEYRFRR--GYS-RNPRKMVRLWAEKEMRNLRRLR CC1G_13652_Ccin_RIO2 EMVLKLHRLGRISFRSIKTKRDYMGK-------R--KSASWMYLSRLSAQKEYAFMKVLY GK011_Glam_RIO2 YVVLKLHKLGRTSFKTAKTKRDYMGP-------R--KSASWMYLSRLAAVREFGFMVALK GK010_Glam_RIO1 NVALKIYSTSILSF---RNRIEYVEGEHRFETVTRSQKSNSRRMVKLWAEKEFRNLIRTQ RIOK3_Hsap_RIO3 RAG-IPCPTVVLLKKHILVMSFIGH-DQVPAPKLKEVKL--NSEEMKEAYYQTLHLMRQL RIOK2_Hsap_RIO2 ERK-FPVPKPIDYNRHAVVMELING---YPLCQIHHV--E----DPASVYDEAMELIVKL RIOK1_Hsap_RIO1 TAE-IPCPEPIMLRSHVLVMSFIGK-DDMPAPLLKNVQL--SESKARELYLQVIQYMRRM CG11660_Dmel_RIO1 ------------------------t---yp------------------------------ CG11859_Dmel_RIO2 ------------------------t---yp------------------------------ CG3008_Dmel_RIO3 ------------------------t---yp------------------------------ RIO2_Scer_RIO2 SKG-FKVPEPFDNSRHIVVMELIEG---YPMRRLRKH--K----NIPKLYSDLMCFIVDL RIO1_Scer_RIO1 QSGVIPAPKPIEVKNNVLVMEFLSRGNGFASPKLKDYPY-KNRDEIFHYYHTMVAYMRLL RIOK1_Mmus_RIO1 TAN-IPCPEPIRLRSHVLLMGFIGK-DDMPAPLLKNVQL--SESKARELYLQVIQYMRKM RIOK2_Mmus_RIO2 ERK-FPVPKPIDYNRHAVIMELING---YPLCQIHHV--E----DPASVYDEAMELIVKL RIOK3_Mmus_RIO3 KAG-IPCPTVVLLKKHILVMSFIGH-DQVPAPKLKEVKL--SNEEMKDAYYQTLHLMQQL Rio1_Ddis_RIO1 ------------------------t---yp------------------------------ Rio2_Ddis_RIO2 ------------------------t---yp------------------------------ 11147_Tthe_RIO1 QSS-IPCPEPLIVKSNVLMMEFIGK-DGKAAPRLKDAEN-IELEQYSKIYLQLLRDMRTL 27105_Tthe_RIO2 KNN-FPTPIPIEQNRHGIVMSLING---VPMQNISEI--D----NPKYVFDQCFYLIKRL CC1G_04984_Ccin_RIO1 AAG-IESPEPVEVRENVLVMTFVGDRDGWASPRLKDAEL--TTDQMIPLYSNLLCLIRTM CC1G_13652_Ccin_RIO2 EHG-FPIPKPIDQARHCVLMEFINA---YPLRQISEV--P----SPGKLYSTLMDLIVRF GK011_Glam_RIO2 ERS-FPVPDPISINRHCVCMSYVEG---IPMHAIKDIDIE----AANLLAKDIHTQMVRM GK010_Glam_RIO1 QLGSICIPKPLFITTTMIGLEFIGY-DRAPAPRLKDVISDLSQARIIKLYWSIMRVLRTL . RIOK3_Hsap_RIO3 YHECTLVHADLSEYNMLWH----------AGKVWLIDVSQSVEPTHPHGLEFLFRDCRNV RIOK2_Hsap_RIO2 -ANHGLIHGDFNEFNLILDE---------SDHITMIDFPQMVSTSHPNAEWYFDRDVKCI RIOK1_Hsap_RIO1 YQDARLVHADLSEFNMLYH----------GGGVYIIDVSQSVEHDHPHALEFLRKDCANV CG11660_Dmel_RIO1 ------------------------------------------------------------ CG11859_Dmel_RIO2 ------------------------------------------------------------ CG3008_Dmel_RIO3 ------------------------------------------------------------ RIO2_Scer_RIO2 -ANSGLIHCDFNEFNIMIKDKLED---ENDCGFVVIDFPQCISIQHQDADYYFQRDVDCI RIO1_Scer_RIO1 YQVCRLVHADLSEYNTIVH----------DDKLYMIDVSQSVEPEHPMSLDFLRMDIKNV RIOK1_Mmus_RIO1 YQDARLVHADLSEFNMLYH----------GGDVYIIDVSQSVEHDHPHALEFLRKDCTNV RIOK2_Mmus_RIO2 -GNHGLIHGDFNEFNLMLDK---------DDHITMIDFPQMVSTSHPNAEWYFDRDVKCI RIOK3_Mmus_RIO3 YNECTLVHADLSEYNMLWH----------AGKVWLIDVSQSVEPTHPHGLEFLFRDCRNV Rio1_Ddis_RIO1 ------------------------------------------------------------ Rio2_Ddis_RIO2 ------------------------------------------------------------ 11147_Tthe_RIO1 YQDCRLVHGDLSEYNLLYY----------NEKLYMIDVSQSIEHDHAHSLEFLRRDIVNV 27105_Tthe_RIO2 -AENGLIHSDFNEFNLMVED---------NGKVIMIDFPQMVSTKHKNAQFYFDRDVECI CC1G_04984_Ccin_RIO1 YHDCKLVHADLSEYNILYH----------EGRLCIIDVSQSVEHDHPSAFDFLRSDIKNV CC1G_13652_Ccin_RIO2 -AQAGLIHGDFNEFNILIREE--------TGEPVVIDFPQMVSTSHENAEWYFNRDVECI GK011_Glam_RIO2 -LRYGIVHGDCNEFNAIVQTSDPENCTPETTRVVIIDFPQVIQSIAPEAEEQFNRDVMSV GK010_Glam_RIO1 YIGAGLVHGDLSEYNLLYL----------NKKLYLIDMGQSVHVTHPNALQFLRIDIINI RIOK3_Hsap_RIO3 SQFFQKGGVKEALSE-RELFNA------VSGL---------------------------- RIOK2_Hsap_RIO2 KDFFMKRFSYE-SEL------------------FPTFK-DIRREDT-------LDVEVSA RIOK1_Hsap_RIO1 NDFFMRHSVA-VMTV-RELFEF------VTDP---------------------------- CG11660_Dmel_RIO1 ------------------------------------------------------------ CG11859_Dmel_RIO2 ------------------------------------------------------------ CG3008_Dmel_RIO3 ------------------------------------------------------------ RIO2_Scer_RIO2 RRFFKKKLKYE-PKPDSSMLDTEGFGDGY-KYAYPDFKRDVKRTDN-------LDELVQA RIO1_Scer_RIO1 NLYFEKMGIS-IFPE-RVIFQF------VISETLEKFKG-DYNNIS-------ALVAYIA RIOK1_Mmus_RIO1 NDFFSKHAVA-VMTV-RELFDF------VTDP---------------------------- RIOK2_Mmus_RIO2 REFFMKRFSYE-SEL------------------YPTFS-DIRKEDS-------LDVEVSA RIOK3_Mmus_RIO3 SQFFQKGGVTEALNE-RELFNA------VSGL---------------------------- Rio1_Ddis_RIO1 ------------------------------------------------------------ Rio2_Ddis_RIO2 ------------------------------------------------------------ 11147_Tthe_RIO1 NMYFKKKNVI-TFSL-R------------------------------------------- 27105_Tthe_RIO2 HVFFERRFNYQ-IT--------------------D------------------------- CC1G_04984_Ccin_RIO1 EEFFGKGGVQ-TLGI-R------------------------------------------- CC1G_13652_Ccin_RIO2 RTFFRRRFRYE-SNL------------------YPRFK-RTMAEGSADGNDFRLDVIVEA GK011_Glam_RIO2 EGFFNRRFGAD-IVL-------------------PRYN-EVMRQISEE-E--LVGQRIDA GK010_Glam_RIO1 NFFFARQGIP-VLSA-REVLAF------ICSP---------------------------- RIOK3_Hsap_RIO3 ------------------------------------------------------------ RIOK2_Hsap_RIO2 -SGY----TKEMQA---------------------------------------------- RIOK1_Hsap_RIO1 ------------------------------------------------------------ CG11660_Dmel_RIO1 ------------------------------------------------------------ CG11859_Dmel_RIO2 ------------------------------------------------------------ CG3008_Dmel_RIO3 ------------------------------------------------------------ RIO2_Scer_RIO2 -SGF----SKKHPGDRGLETAVESMRNAVY----------------------------NS RIO1_Scer_RIO1 -SNLPIKSTEQDEAEDEIFRSL-------HLVRSLGGLEERDFDRYTDGKFDLLKSLIA- RIOK1_Mmus_RIO1 ------------------------------------------------------------ RIOK2_Mmus_RIO2 -SGY----TKEMQA---------------------------------------------- RIOK3_Mmus_RIO3 ------------------------------------------------------------ Rio1_Ddis_RIO1 ------------------------------------------------------------ Rio2_Ddis_RIO2 ------------------------------------------------------------ 11147_Tthe_RIO1 ------------------------------------------------------------ 27105_Tthe_RIO2 ------------------------------------------------------------ CC1G_04984_Ccin_RIO1 ------------------------------------------------------------ CC1G_13652_Ccin_RIO2 -SG--------------------------------------------------------- GK011_Glam_RIO2 TEAF----VKEMVA---------------------------------------------- GK010_Glam_RIO1 ------------------------------------------------------------ RIOK3_Hsap_RIO3 --------------------------------------------------NITADNEA RIOK2_Hsap_RIO2 D--------------------------------------------------DELLHPL RIOK1_Hsap_RIO1 --------------------------------------------------SITHENMD CG11660_Dmel_RIO1 ------------------------------------------------------ical CG11859_Dmel_RIO2 ------------------------------------------------------ical CG3008_Dmel_RIO3 ------------------------------------------------------ical RIO2_Scer_RIO2 DDDMSNDEAEEENGEGDYSEEDEYYDSELDNESSEDDSEDAQEEENERIIEALSSGVE RIO1_Scer_RIO1 -----H-----------------------------DNE-----------RNFAASEQF RIOK1_Mmus_RIO1 --------------------------------------------------SITADNMD RIOK2_Mmus_RIO2 D--------------------------------------------------DELLHPV RIOK3_Mmus_RIO3 --------------------------------------------------NISADNEA Rio1_Ddis_RIO1 ------------------------------------------------------ical Rio2_Ddis_RIO2 ------------------------------------------------------ical 11147_Tthe_RIO1 --------------------------------------------------------DI 27105_Tthe_RIO2 ---------------------------------------------------TLDFNKI CC1G_04984_Ccin_RIO1 --------------------------------------------------------KA CC1G_13652_Ccin_RIO2 ------------------------------------------------------FSKN GK011_Glam_RIO2 K-------------------------------------------------YDPDEELE GK010_Glam_RIO1 --------------------------------------------------NIPKTDDM