CLUSTAL W (1.83) multiple sequence alignment MAP2K7_Hsap_MEK7 LENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRS-GN--------KEENKRILMDLDVV MAP2K6_Hsap_MEK3 LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRAT-VN--------SQEQKRLLMDLDIS MAP2K5_Hsap_MEK5 IRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILL-DIT--------LELQKQIMSELEIL MAP2K4_Hsap_MEK4 LKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRST-VD--------EKEQKQLLMDLDVV MAP2K3_Hsap_MEK3 LVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRAT-VN--------SQEQKRLLMDLDIN MAP2K2_Hsap_MEK1 FERISELGAGNGGVVTKVQHRPSGLIMARKLIHL-EIK--------PAIRNQIIRELQVL MAP2K1_Hsap_MEK1 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHL-EIK--------PAIRNQIIRELQVL MAP2K7_Mmus_MEK7 LENLGEMGSGTCGQVWKMRFRKTGHIIAVKQMRRS-GN--------KEENKRILMDLDVV MAP2K6_Mmus_MEK3 LEPIVELGRGAYGVVEKMRHVPSGQIMAVKRIRAT-VN--------SQEQKRLLMDLDVS MAP2K5_Mmus_MEK5 IRYRDTLGHGNGGTVYKAHHVPSGKILAVKVILL-DIT--------LELQKQIMSELEIL MAP2K4_Mmus_MEK4 LKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRST-VD--------EKEQKQLLMDLDVV MAP2K3_Mmus_MEK3 LVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRAT-VN--------TQEQKRLLMDLDIN MAP2K2_Mmus_MEK1 FERISELGAGNGGVVTKARHRPSGLIMARKLIHL-EIK--------PAVRNQIIRELQVL MAP2K1_Mmus_MEK1 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHL-EIK--------PAIRNQIIRELQVL mkk-4_Cele_MEK4 LQDLGAIGNGNFGTVYKMRHKETGKLIAVKRIRCN-NIG-------HREQIRLLREHDTI mek-2_Cele_MEK1 lqtegelghgnggvvnkcvhrktgvimarklvhl-eik--------psvrqqivkelavl mek-1_Cele_MEK7 LQFVEDIGHGSCGTVTKCRYK--SVIMAVKTMPRT-SN--------SYEMSRILMDLDVI jkk-1_Cele_MEK7 IHIISLLGSGSCGVVESAT-----------TMYK-NDN--------KENLKRILRDVRIM F35C8.2_Cele_STE7-Unclassified LHGGVRIGSGEGQS-AVYRLIYNGMVIARKDVAVR-LPQGGDEDSTNKLMAKRLREVNVI F35C8.1_Cele_STE7-Unclassified LYGGERIGNGEGQS-AVYRLIYNGKLIARKDVAVR-LPKGVDQDSTNKLMAKKLREVNVI E02D9.1_Cele_STE7-Unclassified LQRGKYVGNGMHATVRMALHEKTQKWYVIKTILS-QNT-------DKT---EYEKEILAY STE7_Scer_STE7-Unclassified LVQLGKIGAGNSGTVVKALHVPDSKIVAKKTIPV-EQNN-------STIINQLVRELSIV PBS2_Scer_STE7-Unclassified LEFLDELGHGNYGNVSKVLHKPTNVIMATKEVRL-ELD--------EAKFRQILMELEVL MKK2_Scer_STE7-Unclassified ITTLGILGEGAGGSVAKCRLKNGKKVFALKTINTMNTD--------PEYQKQIFRELQFN MKK1_Scer_STE7-Unclassified IETLGILGEGAGGSVSKCKLKNGSKIFALKVINTLNTD--------PEYQKQIFRELQFN Dsor1_Dmel_MEK1 LEKLGELGSGNGGVVMKVRHTHTHLIMARKLIHL-EVK--------PAIKKQILRELKVL lic_Dmel_MEK3 LEKICDLGRGAYGIVDKMRHKQTDTVLAVKRIPMT-VN--------IREQHRLVMDLDIS Mkk4_Dmel_MEK4 LEDEGEIGRGAFGAVNKMTFKKLDKVMAVKRIRST-VD--------EKEQKQLLMDLEVV hep_Dmel_MEK7 LKHLGDLGNGTSGNVVKMMHLSSNTIIAVKQMRRT-GN--------AEENKRILMDLDVV sek-1_Cele_MEK3 LVVLEELGKGGYGIVEKMQHRQSGIIMAVKRIKSS-IN--------DQSQKQMLNELDAC VZC374L.1_Cele_MEK4 LRHLSQVGAGYYGTVHKMQHNESGRLIAVKKIRYN--N--------ICDQTRLLKEHDTH ZC449.6_Cele_MEK4 LQELELLGNGSFGVVRKMLHRPSNVEMAVKQISLI-NNG-P-DDAFNKSMQRFRLEVEAT Mek1_Ddis_STE7-Unclassified LKIIRVLGRGAGGVVKLAYHETSGTYIALKVITL-DIQ--------ENIRKQIILELKTL 12278_Tthe_STE7-Unclassified FETISELGRGASGRVFKVKHKETGKFYAKKEIRI-NDD--------EMFQKQLIWEIKTL 1557_Tthe_STE7-Unclassified ------------------------------------------------------------ 1909_Tthe_STE7-Unclassified LRRVKVLGHGSSGLVELAVHDATGIVIGIKSIPL-LMN--------SSFRKQLDQELKTL 26687_Tthe_STE7-Unclassified FEVVSELGKGAFGKVYKVCHKKDGKIYAMKEIIM-VDD--------IELRQKILMEVKTL MEK_Spur_MEK1 FEVLKELGAGNGGVVTKVKHKMSGMVMARKLIKL-EIK--------PAIRNQIIRELKVL MEK3_Spur_MEK3 MIVIENLGRGAYGIVDKTRHEPTESIMAVKKMRAQ-VN--------STEDKRILMDMDVA MKK4_Spur_MEK4 LEDMGEIGRGAFGSVNKMWHKQSQSIMAVKRIRST-VD--------EKDQKQLLMDLDVV MKK5_Spur_MEK5 ------------------------------------------------------------ MKK7_Spur_MEK7 LESIGELGFGSCGHVIRMRHKESGTILAVKQMRRS-GN--------KEENKRILMDLDVV CC1G_02205_Ccin_MEK1 LKKLSDLGQGNGGSVEKVEHLPTGTIMAKKSVLI-DAK--------SSVRKQILRELDIM CC1G_03368_Ccin_MEK1 LVDIHDLGQGNGGSVKKVEHTPTKMIMAKKTVLI-DAK--------PSVRKQILRELHIM CC1G_01983_Ccin_STE7-Unclassified FEEISRLGEGAGGAVHKVKDKRNGMIMARKTIT-T--R--------EAPMKQLLRELTIM CC1G_14241_Ccin_STE7-Unclassified QLDDEELGRGNYGTVKKVLHKPTNVAMAMKEIRD-SIQ---------ANSPAIIMELDVL AqueK243_Aque_MEK1 FERLSELGHGNGGVVLKVMHKPSGIIMARKMILL-DIK--------PTVRNQIMRELKVL AqueK244_Aque_MEK4 ---VSEIGRGQFGQVNKMTHMVTGKVMAVKRIRVT-PD--------QAKSKSLLMEWKVP AqueK245_Aque_MEK4 LDVEEELGRGQYGQVNRMKHKPTGKIMAVKRIRAT-PD--------QAENKRLLMDYNVA AqueK246_Aque_MEK4 LQDIGSIGEGHFGVVSKMNHTTAKHIMAVKKIPMK-DL---------RTSGGNVLELDVI AqueK247_Aque_MEK5 ------------------------------------------------------------ AqueK248_Aque_MEK7 MLDVKRVGSGISGEVYRMVHNPSSIAIAAKKMLWQHDT--------WEEQRRVLMDLEVM STE7-p1-1_Smoe_STE7-plant1 ------IGWGASSVVRKAIHIPTHRILALKKINV-FE---------KEKRQQLLNEIRTL STE7-p1-2_Smoe_STE7-plant1 ------IGWGASSVVRKAIHIPTHRILALKKINV-FE---------KEKRQQLLNEIRTL STE7-p2-2_Smoe_STE7-plant2 LEAVKVIGKGSSGVVQLVRHKWTGQVFALKAIQM-NIQ--------ETMRKQIVQEIKIN STE7-p2-1_Smoe_STE7-plant2 LEAVKVIGKGSSGVVQLVRHKWTGQVFALKAIQM-NIQ--------ETMRKQIVQEIKIN GK083_Glam_MEK1 LEVVKPLGAGAFGTVNLVKVKTTGQLCAMKEIRI-SDE--------EQTQKNIYREIKAS MAP2K7_Hsap_MEK7 LKSHDCPYIVQCFGTFITNT----DV-FIAMELMGT-CAEKLKKR--------------- MAP2K6_Hsap_MEK3 MRTVDCPFTVTFYGALFREG----DV-WICMELMDT-SLDKFYKQVID------------ MAP2K5_Hsap_MEK5 YKC-DSSYIIGFYGAFFVE----NRI-SICTEFMDGGSLDVY------------------ MAP2K4_Hsap_MEK4 MRSSDCPYIVQFYGALFREG----DC-WICMELMST-SFDKFYKYVYS------------ MAP2K3_Hsap_MEK3 MRTVDCFYTVTFYGALFREG----DV-WICMELMDT-SLDKFYRKVLD------------ MAP2K2_Hsap_MEK1 HEC-NSPYIVGFYGAFYSD----GEI-SICMEHMDGGSLDQVLKE--------------- MAP2K1_Hsap_MEK1 HEC-NSPYIVGFYGAFYSD----GEI-SICMEHMDGGSLDQVLKK--------------- MAP2K7_Mmus_MEK7 LKSHDCPYIVQCFGTFITNT----DV-FIAMELMGT-CAEKLKKR--------------- MAP2K6_Mmus_MEK3 MRTVDCPFTVTFYGALFREG----DV-WICMELMDT-SLDKFYKQVID------------ MAP2K5_Mmus_MEK5 YKC-DSSYIIGFYGAFFVE----NRI-SICTEFMDGGSLDVY------------------ MAP2K4_Mmus_MEK4 MRSSDCPYIVQFYGALFREG----DC-WICMELMST-SFDKFYKYVYS------------ MAP2K3_Mmus_MEK3 MRTVDCFYTVTFYGALFREG----DV-WICMELMDT-SLDKFYRKVLE------------ MAP2K2_Mmus_MEK1 HEC-NSPYIVGFYGAFYSD----GEI-SICMEHMDGGSLDQVLKE--------------- MAP2K1_Mmus_MEK1 HEC-NSPYIVGFYGAFYSD----GEI-SICMEHMDGGSLDQVLKK--------------- mkk-4_Cele_MEK4 VKSEKGPNIVKFYGAIFSEG----DC-WICMELMDI-SMDLLYKRVYM------------ mek-2_Cele_MEK1 hkc-nspfivgfygafvdn----ndi-sicmeymdglsldivlkk--------------- mek-1_Cele_MEK7 CLSFDCPYIVRCFGYFITNF----DV-RVCMECMAT-CLDRLLIR--------------- jkk-1_Cele_MEK7 -SMCNSPFIVTSYGYFMFDS----SV-KICMQIMSA-CCEKLLRRIYH------------ F35C8.2_Cele_STE7-Unclassified NGCAPCPFIVHFFGYYVHKYKDCVKI-HIFMEEMAL-SASVLKKEVLK------------ F35C8.1_Cele_STE7-Unclassified NGCAPCPFIVHFFGYYVHKYRDCVKI-HIFMEEMAL-SASVLKTEALK------------ E02D9.1_Cele_STE7-Unclassified EECSQSDYVVGYHGCEVSS----IKK-ELVLEYMDKGDFR-------------------- STE7_Scer_STE7-Unclassified KNVKPHENIITFYGAYYNQHIN-NEI-IILMEYSDCGSLDKILSVYKRFVQRG------- PBS2_Scer_STE7-Unclassified HKC-NSPYIVDFYGAFFIE----GAV-YMCMEYMDGGSLDKIYDESS------------- MKK2_Scer_STE7-Unclassified KSF-KSDYIVQYYGMFTDEQ-S-SSI-YIAMEYMGGKSLEATYKNLL------------- MKK1_Scer_STE7-Unclassified RSF-QSEYIVRYYGMFTDDE-N-SSI-YIAMEYMGGRSLDAIYKNLL------------- Dsor1_Dmel_MEK1 HEC-NFPHIVGFYGAFYSD----GEI-SICMEYMDGGSLDLILKR--------------- lic_Dmel_MEK3 MRSSDCPYTVHFYGAMYREG----DV-WICMEVMST-SLDKFYPKVFL------------ Mkk4_Dmel_MEK4 MKSNECIYIVQFYGALFKEG----DC-WICMELMDT-SLDKFYKYIYE------------ hep_Dmel_MEK7 LKSHDCKYIVKCLGCFVRDP----DV-WICMELMSM-CFDKLLKL--------------- sek-1_Cele_MEK3 RRSDCCPQMVRFYGAMFREG----DV-WICMEVMDT-SLDKFYRHAYK------------ VZC374L.1_Cele_MEK4 MKSENVPNIVKFFGACFSEG----DC-WICMELMDI-SIDFLYKRVYS------------ ZC449.6_Cele_MEK4 KAASNCDEIVRYYGITFNEG----VA-WMCMELMDL-SLDKLYMIAHD------------ Mek1_Ddis_STE7-Unclassified HK-TSYPYIVSFYDAFYTE----GSI-FIALEFMELGSLSDIMKK--------------- 12278_Tthe_STE7-Unclassified FS-CNSPHIVQYYCAFYTE----CML-HLILEYMDMGTLDTILKKT-------------- 1557_Tthe_STE7-Unclassified -----HPNLITCFGAYYEE----GTI-KIILELMDFGSIRNLIDML-------------- 1909_Tthe_STE7-Unclassified IQ-CESDSIVKCYGAYIQK----CMI-NITLEYMDLGTVHDLVKK--------------- 26687_Tthe_STE7-Unclassified FI-CQSPYIVTYYGAFYTE----GKL-HIILEYMDVGTLDSLLKKA-------------- MEK_Spur_MEK1 HEC-NSPYIVGFFGAYYSD----GEI-CICMENMDGGSLDQVMKSA-------------- MEK3_Spur_MEK3 MRSSDCVYTVEFYGALFQEG----DV-WICMEVMDT-CLDKLYKNKLK------------ MKK4_Spur_MEK4 KRSANCVYIIKFFGALFKEG----DC-WICMELMDS-SLDKFYRFVHE------------ MKK5_Spur_MEK5 -KC-DSPFIIGFYGAFFTE----NRI-SICTEFMDGGSLEMY------------------ MKK7_Spur_MEK7 LKSHNCPFIVQCLGAIVTPS----EV-WICMEQMAT-CLDKLIKK--------------- CC1G_02205_Ccin_MEK1 HEC-QSDYIISCFGSFLAE----PNI-CICMEFMDKGSFDGIYKK--------------- CC1G_03368_Ccin_MEK1 HDC-RSDYIISFYGAFLAD----NNI-CICMEFMDKGSLDGIYKK--------------- CC1G_01983_Ccin_STE7-Unclassified SST-KHVNIITFYGAYMSPS-S-SEI-KIIMEYCEGGSLESVGKRIR------------- CC1G_14241_Ccin_STE7-Unclassified HRA-VAPEIVEFYGAFFIE----SCV-YYCMEYMDAGSLDKLIQSNSQPPQPQIPKPPSS AqueK243_Aque_MEK1 HDC-NASYIVGFFGSFHVN----NEI-SILMQHMDGGSLDLVL-N--------------- AqueK244_Aque_MEK4 KNSVECPYTILFYGAFFCEN----DV-WICMELMDR-SLEELYHLVYD------------ AqueK245_Aque_MEK4 MRSIDCPFTITFYGALFREG----DV-WICMELMDK-SLDKLYQLVYK------------ AqueK246_Aque_MEK4 KKVKECPFIVHFYGCLLREG----HV-WICMELLDS-SMAQVSEIVYN------------ AqueK247_Aque_MEK5 ----DSQYIIGFYGSFFQE----NRI-SICTEYMDGGSLDQY------------------ AqueK248_Aque_MEK7 -NSQHSPFIVEYYGSAIVKN----EV-WVFMELMAT-CLDRLLKR--------------- STE7-p1-1_Smoe_STE7-plant1 CEAPMAKGLVEFYGAFYSPD-S-GQI-SIALEYMDGGSLADIVRN--------------- STE7-p1-2_Smoe_STE7-plant1 CEAPMAKGLVEFYGAFYSPD-S-GQI-SIALEYMDGGSLADIVRN--------------- STE7-p2-2_Smoe_STE7-plant2 QS-SQCPYVVVCYEAFYNN----GVI-SIVFEYMDGGSLLDVIKE--------------- STE7-p2-1_Smoe_STE7-plant2 QS-SQCPYVVVCYEAFYNN----GVI-SIVFEYMDGGSLLDVIKE--------------- GK083_Glam_MEK1 ISLSCNPYMVKTYNIYSHP----GSILHILLEFCKYGSSQDMLKKL-------------- : : MAP2K7_Hsap_MEK7 --------------------------------------------------MQGPIPERIL MAP2K6_Hsap_MEK3 --------------------------------------------------KGQTIPEDIL MAP2K5_Hsap_MEK5 ----------------------------------------------------RKMPEHVL MAP2K4_Hsap_MEK4 -------------------------------------------------VLDDVIPEEIL MAP2K3_Hsap_MEK3 --------------------------------------------------KNMTIPEDIL MAP2K2_Hsap_MEK1 ---------------------------------------------------AKRIPEEIL MAP2K1_Hsap_MEK1 ---------------------------------------------------AGRIPEQIL MAP2K7_Mmus_MEK7 --------------------------------------------------MQGPIPERIL MAP2K6_Mmus_MEK3 --------------------------------------------------KGQTIPEDIL MAP2K5_Mmus_MEK5 ----------------------------------------------------RKIPEHVL MAP2K4_Mmus_MEK4 -------------------------------------------------VLDDVIPEEIL MAP2K3_Mmus_MEK3 --------------------------------------------------KNMKIPEDIL MAP2K2_Mmus_MEK1 ---------------------------------------------------AKRIPEDIL MAP2K1_Mmus_MEK1 ---------------------------------------------------AGRIPEQIL mkk-4_Cele_MEK4 -------------------------------------------------VKNSRLNENVV mek-2_Cele_MEK1 ---------------------------------------------------vgrlpekfv mek-1_Cele_MEK7 --------------------------------------------------IKQPIPERII jkk-1_Cele_MEK7 -------------------------------------------------SKLDFFPEFVA F35C8.2_Cele_STE7-Unclassified --------------------------------------------------RGGIVPEFVI F35C8.1_Cele_STE7-Unclassified --------------------------------------------------QGGAIPEFVI E02D9.1_Cele_STE7-Unclassified --------------------------------------------------PFGILPFSVH STE7_Scer_STE7-Unclassified ----------------------------------------------TVSSKKTWFNELTI PBS2_Scer_STE7-Unclassified --------------------------------------------------EIGGIDEPQL MKK2_Scer_STE7-Unclassified -------------------------------------------------KRGGRISERVI MKK1_Scer_STE7-Unclassified -------------------------------------------------ERGGRISEKVL Dsor1_Dmel_MEK1 ---------------------------------------------------AGRIPESIL lic_Dmel_MEK3 --------------------------------------------------HDLRMEESVL Mkk4_Dmel_MEK4 -------------------------------------------------KQQRHIPESIL hep_Dmel_MEK7 --------------------------------------------------SKKPVPEQIL sek-1_Cele_MEK3 --------------------------------------------------IGKHIPEPFI VZC374L.1_Cele_MEK4 -------------------------------------------------VKKSRLNENII ZC449.6_Cele_MEK4 -------------------------------------------------IQKVEIPEQIL Mek1_Ddis_STE7-Unclassified ---------------------------------------------------TSTIPEPVL 12278_Tthe_STE7-Unclassified ----------------------------------------------------KQVSEPIL 1557_Tthe_STE7-Unclassified ----------------------------------------------------KEINYCYL 1909_Tthe_STE7-Unclassified ---------------------------------------------------VGPLPEIIV 26687_Tthe_STE7-Unclassified ---------------------------------------------------GGKVSEVVL MEK_Spur_MEK1 --------------------------------------------------PKGRIPENIL MEK3_Spur_MEK3 -------------------------------------------------PQKIFVPENIL MKK4_Spur_MEK4 -------------------------------------------------VQNTYIPENIM MKK5_Spur_MEK5 ----------------------------------------------------RCIPESIL MKK7_Spur_MEK7 --------------------------------------------------LREPVPEQII CC1G_02205_Ccin_MEK1 ---------------------------------------------------LGPLQVEVV CC1G_03368_Ccin_MEK1 ---------------------------------------------------IGAIDIDIV CC1G_01983_Ccin_STE7-Unclassified -------------------------------------------------ERGAIVGEKIA CC1G_14241_Ccin_STE7-Unclassified DPIQTDASSPEYSFAMPFVEEDLDLTKDENFEPYNRAFNRTCPPPIPSTYSGGPIPEAIL AqueK243_Aque_MEK1 ---------------------------------------------------TGRIPVDMI AqueK244_Aque_MEK4 -------------------------------------------------KLKESIP---- AqueK245_Aque_MEK4 -------------------------------------------------KLNEKIPEVIV AqueK246_Aque_MEK4 -------------------------------------------------KMNERIPEDIL AqueK247_Aque_MEK5 ----------------------------------------------------APLSETVL AqueK248_Aque_MEK7 --------------------------------------------------LKGPIPERII STE7-p1-1_Smoe_STE7-plant1 ---------------------------------------------------KKFIPEPIL STE7-p1-2_Smoe_STE7-plant1 ---------------------------------------------------KKFIPEPIL STE7-p2-2_Smoe_STE7-plant2 ---------------------------------------------------VNALPEPYL STE7-p2-1_Smoe_STE7-plant2 ---------------------------------------------------VNALPEPYL GK083_Glam_MEK1 --------------------------------------------------KTGKLTENAL . MAP2K7_Hsap_MEK7 GK------------MTVAIVKALYYLKE-KHGVIHRDVKPSNILLD-ERGQIKLCDFGIS MAP2K6_Hsap_MEK3 GK------------IAVSIVKALEHLHS-KLSVIHRDVKPSNVLIN-ALGQVKMCDFGIS MAP2K5_Hsap_MEK5 GR------------IAVAVVKGLTYLWS--LKILHRDVKPSNMLVN-TRGQVKLCDFGVS MAP2K4_Hsap_MEK4 GK------------ITLATVKALNHLKE-NLKIIHRDIKPSNILLD-RSGNIKLCDFGIS MAP2K3_Hsap_MEK3 GE------------IAVSIVRALEHLHS-KLSVIHRDVKPSNVLIN-KEGHVKMCDFGIS MAP2K2_Hsap_MEK1 GK------------VSIAVLRGLAYLRE-KHQIMHRDVKPSNILVN-SRGEIKLCDFGVS MAP2K1_Hsap_MEK1 GK------------VSIAVIKGLTYLRE-KHKIMHRDVKPSNILVN-SRGEIKLCDFGVS MAP2K7_Mmus_MEK7 GK------------MTVAIVKALYYLKE-KHGVIHRDVKPSNILLD-ERGQIKLCDFGIS MAP2K6_Mmus_MEK3 GK------------IAVSIVKALEHLHS-KLSVIHRDVKPSNVLIN-TLGQVKMCDFGIS MAP2K5_Mmus_MEK5 GR------------IAVAVVKGLTYLWS--LKILHRDVKPSNMLVN-TGGQVKLCDFGVS MAP2K4_Mmus_MEK4 GK------------ITLATVKALNHLKE-NLKIIHRDIKPSNILLD-RSGNIKLCDFGIS MAP2K3_Mmus_MEK3 GE------------IAVSIVRALEHLHS-KLSVIHRDVKPSNVLIN-KEGHVKMCDFGIS MAP2K2_Mmus_MEK1 GK------------VSIAVLRGLAYLRE-KHQIMHRDVKPSNILVN-SRGEIKLCDFGVS MAP2K1_Mmus_MEK1 GK------------VSIAVIKGLTYLRE-KHKIMHRDVKPSNILVN-SRGEIKLCDFGVS mkk-4_Cele_MEK4 GH------------ITVCTVDALDYLKK-ELKIIHRDVKPSNILVD-GTGAVKLCDFGIC mek-2_Cele_MEK1 gr------------isvavvrgltylkd-eikilhrdvkpsnmlvn-sngeiklcdfgvs mek-1_Cele_MEK7 GK------------LSVSIIKALHYLKT-KHQIMHRDVKPSNILLD-WSGVIKLCDFGIA jkk-1_Cele_MEK7 GH------------IVYSAISALDYLKE-KHSIIHRDIKPSNILFD-DSGNVKLCDFGIS F35C8.2_Cele_STE7-Unclassified GR------------IACSVIHAMWFLKE-KMQIIHRDIKPGNILID-YDGRVKICDFGIS F35C8.1_Cele_STE7-Unclassified GR------------IVCSVIHAMWFLKD-RLQIIHRDIKPGNILID-YDGRVKICDFGIC E02D9.1_Cele_STE7-Unclassified QS------------VALSLIRAIRHVWNSGPGYIHRDIKPENILVN-SQGYVKICDFGAA STE7_Scer_STE7-Unclassified SK------------IAYGVLNGLDHLYR-QYKIIHRDIKPSNVLIN-SKGQIKLCDFGVS PBS2_Scer_STE7-Unclassified AF------------IANAVIHGLKELKE-QHNIIHRDVKPTNILCSANQGTVKLCDFGVS MKK2_Scer_STE7-Unclassified GK------------IAESVLRGLSYLHE-R-KVIHRDIKPQNILLN-EKGEIKLCDFGVS MKK1_Scer_STE7-Unclassified GK------------IAEAVLRGLSYLHE-K-KVIHRDIKPQNILLN-ENGQVKLCDFGVS Dsor1_Dmel_MEK1 GR------------ITLAVLKGLSYLRD-NHAIIHRDVKPSNILVN-SSGEIKICDFGVS lic_Dmel_MEK3 GK------------IAMSVVSALHYLHA-QLKVIHRDVKPSNILIN-RAGQVKICDFGIS Mkk4_Dmel_MEK4 AK------------ITVATVNALNYLKE-ELKIIHRDVKPSNILLH-RRGDIKLCDFGIS hep_Dmel_MEK7 GK------------VTVATVNALSYLKD-KHGVIHRDVKPSNILID-ERGNIKLCDFGIS sek-1_Cele_MEK3 GK------------MALSVIEGLNFMKE-QLNLIHRDVKPSNILLN-RHGQVKICDFGIS VZC374L.1_Cele_MEK4 GH------------ITVCIVDALDYLKR-KLNRIHRDVKPSNILIN-AAGDVKLCDFGIC ZC449.6_Cele_MEK4 GA------------VAVATIRALEHLKT-THHIIHRDIKPSNILLD-RHGCVKLCDFGIC Mek1_Ddis_STE7-Unclassified GK------------IAFQVLQGLVYLHR-KLHLIHRDIKPSNILVN-NKGEAKIADFGVS 12278_Tthe_STE7-Unclassified IY------------TTYQIIKGIHYLHK-DLKIIHRDLKPGNILVN-SEGEIKISDLGIC 1557_Tthe_STE7-Unclassified SKILCNQKYQYHFFILKQLLKGLEFLHK-ERHQVHRDIKPENILIN-KRGNVKLTDFGIS 1909_Tthe_STE7-Unclassified AI------------MAIQVLKGLDYIHN-KAKVIHRDIKPSNLLVN-SKGQVKIADFGVS 26687_Tthe_STE7-Unclassified KY------------LTYQILKGLKYLHK-DLHIIHRDIKPGNILVN-SKGEIKISDLGIC MEK_Spur_MEK1 GK------------VTVAVLRGLIYLRD-VHDIMHRDVKPSNILVN-SRGEIKLCDFGVS MEK3_Spur_MEK3 SR------------ISFSIVSALKYLQT-RLKVIHRDVKPSNVLAN-HNGKIKLCDFGIS MKK4_Spur_MEK4 GK------------VAYATVKALNYLKE-TLKIIHRDVKPSNILLD-RGGNIKLCDFGIS MKK5_Spur_MEK5 GR------------MTVSIVKGLNYLWN--LKIMHRDVKPSNILVN-TQGEIKLCDFGVS MKK7_Spur_MEK7 GK------------MVVAIVNALNYLKE-KHGVMHRDVKPSNMLLD-EKGVVKLCDFGIS CC1G_02205_Ccin_MEK1 GM------------VALSVLEGLTYLYD-VHRIMHRDIKPSNILFN-SQGQIKLCDFGVS CC1G_03368_Ccin_MEK1 GK------------IALAVLEGLTYLYD-VHRIIHRDIKPSNILCN-SRGQIKICDFGVS CC1G_01983_Ccin_STE7-Unclassified GR------------LAEGVLQGLSYLHS-K-KTIHRDIKPSNILLS-KEGVVKLCDFGVS CC1G_14241_Ccin_STE7-Unclassified GR------------IAASMVRGLKFLKD-ELNIIHRDVKPTNVLVN-CKGQVKLCDFGVS AqueK243_Aque_MEK1 GQ------------ITVAVLNGLKYLRD-THHIIHRDVKPSNILVN-SEGEIKLCDFGVS AqueK244_Aque_MEK4 ----------------ELTLKALTYLHD-KLNVMHRDVKPSNILIN-QNGEIKLCDFGIA AqueK245_Aque_MEK4 GK------------MADSTLKALTYLHD-ELQVMHRDVKPSNILIN-KKGEIKLCDFGIA AqueK246_Aque_MEK4 GK------------MTVAVINALHFLQK-ELKIIHRDVKPSNILVS-KVGEFKLCDFGIS AqueK247_Aque_MEK5 SK------------ITAAILKGLNYLWS--IKVLHRDIKPSNMLVN-THGQIKLCDFGVS AqueK248_Aque_MEK7 GK------------MCVSIVKALDYLKR-AHKVIHRDVKPSNILID-VNGNVKLCDFGIS STE7-p1-1_Smoe_STE7-plant1 SV------------ITRKVLQGLQFLHG-VRHLVHRDIKPANLLIN-LIGEPKITDFGIS STE7-p1-2_Smoe_STE7-plant1 SV------------ITRKVLQGLQFLHG-VRHLVHRDIKPANLLIN-LIGEPKITDFGIS STE7-p2-2_Smoe_STE7-plant2 AA------------ICKQVLKGLVYLHL-DRRIIHRDIKPSNLLVN-HKGEVKITDFGVS STE7-p2-1_Smoe_STE7-plant2 AA------------ICKQVLKGLVYLHL-DRRIIHRDIKPSNLLVN-HKGEVKITDFGVS GK083_Glam_MEK1 AV------------FIIDTLRGLAYLHD-NCKIIHRDIKSANILID-EHGYCKLADFGVA : .: : :***:*. *:* * *: *:* . MAP2K7_Hsap_MEK7 GRLVD---SKAKT-RSAGCAAYMAPERIDPPDP--------------------------- MAP2K6_Hsap_MEK3 GYLVD---SVAKT-IDAGCKPYMAPERINPEL---------------------------- MAP2K5_Hsap_MEK5 TQLVN---SIAKT--YVGTNAYMAPERIS------------------------------- MAP2K4_Hsap_MEK4 GQLVD---SIAKT-RDAGCRPYMAPERIDPSA---------------------------- MAP2K3_Hsap_MEK3 GYLVD---SVAKT-MDAGCKPYMAPERINPEL---------------------------- MAP2K2_Hsap_MEK1 GQLID---SMANS--FVGTRSYMAPERLQ------------------------------- MAP2K1_Hsap_MEK1 GQLID---SMANS--FVGTRSYMSPERLQ------------------------------- MAP2K7_Mmus_MEK7 GRLVD---SKAKT-RSAGCAAYMAPERIDPPDP--------------------------- MAP2K6_Mmus_MEK3 GYLVD---SVAKT-IDAGCKPYMAPERINPEL---------------------------- MAP2K5_Mmus_MEK5 TQLVN---SIAKT--YVGTNAYMAPERIS------------------------------- MAP2K4_Mmus_MEK4 GQLVD---SIAKT-RDAGCRPYMAPERIDPSA---------------------------- MAP2K3_Mmus_MEK3 GYLVD---SVAKT-MDAGCKPYMAPERINPEL---------------------------- MAP2K2_Mmus_MEK1 GQLID---SMANS--FVGTRSYMSPERLQ------------------------------- MAP2K1_Mmus_MEK1 GQLID---SMANS--FVGTRSYMSPERLQ------------------------------- mkk-4_Cele_MEK4 GQLEE---SFAKT-HDAGCQPYLAPERITS------------------------------ mek-2_Cele_MEK1 gmlid---smans--fvgtrsymaperlt------------------------------- mek-1_Cele_MEK7 GRLIE---SRAHS-KQAGCPLYMGPERLDPN----------------------------- jkk-1_Cele_MEK7 GFMTD---SMAHS-KSAGCPPYMAPERLTIE----------------------------- F35C8.2_Cele_STE7-Unclassified GILQD---SIAVS--ATGCQQYTAPEINELAMV--------------------------- F35C8.1_Cele_STE7-Unclassified GILEN---SIAVS--DTGCQQYTAPEILVKGVS--------------------------- E02D9.1_Cele_STE7-Unclassified KRIDN---TYRIASSAAGTQMYQAPEQQM------------------------------- STE7_Scer_STE7-Unclassified KKLIN---SIADT--FVGTSTYMSPERIQ------------------------------- PBS2_Scer_STE7-Unclassified GNLVA---SLAKT--NIGCQSYMAPERIKSLNP--------------------------- MKK2_Scer_STE7-Unclassified GEAVN---SLAMT--FTGTSFYMAPERIQ------------------------------- MKK1_Scer_STE7-Unclassified GEAVN---SLATT--FTGTSFYMAPERIQ------------------------------- Dsor1_Dmel_MEK1 GQLID---SMANS--FVGTRSYMSPERLQ------------------------------- lic_Dmel_MEK3 GYLVD---SIAKT-IDAGCKPYMAPERIDPQG---------------------------- Mkk4_Dmel_MEK4 GQLVD---SIAKT-KDAGCRPYMAPERIDPE----------------------------- hep_Dmel_MEK7 GRLVD---SKANT-RSAGCAAYMAPERIDPK----------------------------- sek-1_Cele_MEK3 GHLTN---SMAKT-VQAGCKPYMPPERIDGE----------------------------- VZC374L.1_Cele_MEK4 GDLVG---SYAIT-VEAGCVQYLAPERIEN------------------------------ ZC449.6_Cele_MEK4 GYLQN---SVAQS-VDVGCRPYMAPERLAP------------------------------ Mek1_Ddis_STE7-Unclassified GQLQH---TLSKAVTWVGTVTYMSPERIS------------------------------- 12278_Tthe_STE7-Unclassified GKVNG---TMDQKNTFVGTTIYMSPERLN------------------------------- 1557_Tthe_STE7-Unclassified KQLEK---TQQLCMTYVGTTLYMSPERLI------------------------------- 1909_Tthe_STE7-Unclassified ANLES---AVEV-KNWVGTVTYMSPERFR------------------------------- 26687_Tthe_STE7-Unclassified GAINA---TLDERQTFVGTSIYMSPERLS------------------------------- MEK_Spur_MEK1 GQLID---SMANS--FVGTRSYMSPERLQ------------------------------- MEK3_Spur_MEK3 GQLVN---SMAKT-QDAGSRQYMAPERIDPDM---------------------------- MKK4_Spur_MEK4 GQLVD---SIART-MDAGCKPYMAPERIDPFQ---------------------------- MKK5_Spur_MEK5 AQLVS---SITRT--YIGTNAYMAPERVL------------------------------- MKK7_Spur_MEK7 GRLVD---SKART-RSAGCAAYMAPERIDPPDP--------------------------- CC1G_02205_Ccin_MEK1 GEVIN---SIANT--FVGTSVYMSPERIQSH----------------------------- CC1G_03368_Ccin_MEK1 GELIN---SIADT--FVGTSTYMSPERIQ------------------------------- CC1G_01983_Ccin_STE7-Unclassified GELIL---SQAGT--FTGTSFYMAPERIQ------------------------------- CC1G_14241_Ccin_STE7-Unclassified GQLDK---SMAKT--NIGCQSYMAPERIRGESRVVGAVPASEGGTGTAAAAQGGVPGTAA AqueK243_Aque_MEK1 GQLIN---SMANS--FVGTRSYMAPERLQ------------------------------- AqueK244_Aque_MEK4 GELVD---SLAKT--DIGCRPYLAPERIDEP----------------------------- AqueK245_Aque_MEK4 GELVN---SLAKT--DIGCRPYLAPERIYGG----------------------------- AqueK246_Aque_MEK4 GKLVD---SIART-MDVGCRPYMAPERIDPAR---------------------------- AqueK247_Aque_MEK5 VQLMT---SLTKT--YIGTNAYMAPERIL------------------------------- AqueK248_Aque_MEK7 GRLVD---SKAFT-RGAGAAAYMAPERINMSH---------------------------- STE7-p1-1_Smoe_STE7-plant1 AGLDN---SIAMCATFVGTVTYMSPERIN------------------------------- STE7-p1-2_Smoe_STE7-plant1 AGLDN---SIAMCATFVGTVTYMSPERIN------------------------------- STE7-p2-2_Smoe_STE7-plant2 AVLAN---SMGQRDTFVGTYTYMSPERIS------------------------------- STE7-p2-1_Smoe_STE7-plant2 AVLAN---SMGQRDTFVGTYTYMSPERIS------------------------------- GK083_Glam_MEK1 SSVLPNDDEAAM-KTFVGSLSYMSPERIQ------------------------------- * * ** MAP2K7_Hsap_MEK7 ----TKPDYDIRADVWSLGISLPCPSPSQVELATGQFPYKN------------------- MAP2K6_Hsap_MEK3 ----NQKGYSVKSDIWSLGITM-------IELAILRFPYDS------------------- MAP2K5_Hsap_MEK5 -----GEQYGIHSDVWSLGISF-------MELALGRFPYPQIQKN--------------- MAP2K4_Hsap_MEK4 ----SRQGYDVRSDVWSLGITL-------YELATGRFPYPK------------------- MAP2K3_Hsap_MEK3 ----NQKGYNVKSDVWSLGITM-------IEMAILRFPYES------------------- MAP2K2_Hsap_MEK1 -----GTHYSVQSDIWSMGLSL-------VELAVGRYPIPPPDAKELEAIFGRPVVDGEE MAP2K1_Hsap_MEK1 -----GTHYSVQSDIWSMGLSL-------VEMAVGRYPIPPPDAKELELMFGCQV----E MAP2K7_Mmus_MEK7 ----TKPDYDIRADVWSLGISLQCLSPSQVELATGQFPYKN------------------- MAP2K6_Mmus_MEK3 ----NQKGYSVKSDIWSLGITM-------IELAILRFPYDS------------------- MAP2K5_Mmus_MEK5 -----GEQYGIHSDVWSLGISF-------MELALGRFPYPQIQKN--------------- MAP2K4_Mmus_MEK4 ----SRQGYDVRSDVWSLGITL-------YELATGRFPYPK------------------- MAP2K3_Mmus_MEK3 ----NQKGYNVKSDVWSLGITM-------IEMAILRFPYES------------------- MAP2K2_Mmus_MEK1 -----GTHYSVQSDIWSMGLSL-------VELAIGRYPIPPPDAKELEASFGRPVVDGAD MAP2K1_Mmus_MEK1 -----GTHYSVQSDIWSMGLSL-------VEMAVGRYPIPPPDAKELELLFGCHV----E mkk-4_Cele_MEK4 -----SDKYDVRSDVWSLGITL-------YEIATGKFPYQEWN----------------- mek-2_Cele_MEK1 -----gshytissdiwsfglsl-------velligrypvpapsqaeyatmfnvae---ne mek-1_Cele_MEK7 ----NFDSYDIRSDVWSFGVTL-------VELATGQYPYAG------------------- jkk-1_Cele_MEK7 ----TNSKYDVRSDVWSLGITV-------YQLVTGLYPFPL------------------- F35C8.2_Cele_STE7-Unclassified ----HSPGYSIKSDIWSLGITI-------FELATL------------------------- F35C8.1_Cele_STE7-Unclassified ----NSPGYSIKSDIWSLGITI-------FELATLRYPYPV------------------- E02D9.1_Cele_STE7-Unclassified -----GQDYSEKVDIWCFGLTL-------WEFAIGPNLEEYLN----------------- STE7_Scer_STE7-Unclassified -----GNVYSIKGDVWSLGLMI-------IELVTGEFPLGGHNDT--------------- PBS2_Scer_STE7-Unclassified ----DRATYTVQSDIWSLGLSI-------LEMALGRYPYPPET----------------- MKK2_Scer_STE7-Unclassified -----GQPYSVTCDVWSLGLTL-------LEVAGGRFPFESDKIT--------------- MKK1_Scer_STE7-Unclassified -----GQPYSVTSDVWSLGLTI-------LEVANGKFPCSSEKMA--------------- Dsor1_Dmel_MEK1 -----GTHYSVQSDIWSLGLSL-------VEMAIGMYPIPPPNTATLESIFADNAE--ES lic_Dmel_MEK3 ----NPAQYDIRSDVWSLGIGM-------IEMATGRYPYDN------------------- Mkk4_Dmel_MEK4 ----RAKGYDVRSDVWSLGITL-------MEVATGNFPYRK------------------- hep_Dmel_MEK7 -----KPKYDIRADVWSLGITL-------VELATARSPYEG------------------- sek-1_Cele_MEK3 ----TKSAYDVRADVWSLGITI-------IEIAVGTHPYAN------------------- VZC374L.1_Cele_MEK4 -----MDKYDIRSDVWSLGITL-------YEIATGVYPYRGWS----------------- ZC449.6_Cele_MEK4 ----NGDGYDIKSEVWSLGITM-------VEVANGKYPYDGFM----------------- Mek1_Ddis_STE7-Unclassified -----GRSYSFDSEIWSLGLTI-------LECAIGKFPYGSNLPHQQQQPLQQQQQ--QQ 12278_Tthe_STE7-Unclassified -----GDSYTMKTDIWSVGLLL-------IEFSEGKHPIQA------------------- 1557_Tthe_STE7-Unclassified -----GNQYGLRSDIWSVGLVI-------IELATGLYPYDVKN----------------- 1909_Tthe_STE7-Unclassified -----GQAYTANTDIWSLGLTI-------CECALGTYPYFDSNQYEKK------------ 26687_Tthe_STE7-Unclassified -----GESYSVKTDIWSFGLLL-------LEFSESKNPLQLNE----------------- MEK_Spur_MEK1 -----GTHYTVQSDIWSLGLSL-------VEMAIGRYPIPAPDETALANLFGYEL---QA MEK3_Spur_MEK3 ----SAKGYDVKSDVWSFGITM-------IEIATNAYPYER------------------- MKK4_Spur_MEK4 ----SRPGYDIRSDVWSLGITM-------YEVATGEFPYPK------------------- MKK5_Spur_MEK5 -----GDEYGVHSEVWSLGVFL-------LEMATGRFPYPATPRD--------------- MKK7_Spur_MEK7 ----NNPDYDVRADVWSLG----------------------------------------- CC1G_02205_Ccin_MEK1 -----GDGYSVKSDVWSLGMSL-------VELALGAFPFTDPPDDD-DDDLSDLEG--DS CC1G_03368_Ccin_MEK1 -----GAQYTVKSDVWSLGISL-------IELALGRFPFSQSDSDESDDEFSDASD--YE CC1G_01983_Ccin_STE7-Unclassified -----GKEYTIRSDVWSTGISL-------LELVQNRFPFPPDL----------------- CC1G_14241_Ccin_STE7-Unclassified LADELYGAYTVSSDVWSLGLSI-------IELGLGRYPYPPET----------------- AqueK243_Aque_MEK1 -----GEVYSVLSDIWSLGVSL-------IEMAIGSYPIPAPPKEQLDEEMRNPP----A AqueK244_Aque_MEK4 -----QHEYDHRSDVWSLGITM-------YEIAMGEFPYPVDT----------------- AqueK245_Aque_MEK4 -----QHKYDHRSDVWSLGITL-------CELATGEFPYPP------------------- AqueK246_Aque_MEK4 ----ACLGYTIQSDVWSYGITL-------VELAQGSFPYKKWN----------------- AqueK247_Aque_MEK5 -----GGEYGVHSEIWSLGLSL-------MELSLGYFP---------------------- AqueK248_Aque_MEK7 ----DSKGYDVRADVWSLGISL-------VEMATGSAPYKFNE----------------- STE7-p1-1_Smoe_STE7-plant1 -----NECYSYPADIWSLGLAL-------LECGTGEFPYNAS------------------ STE7-p1-2_Smoe_STE7-plant1 -----NECYSYPADIWSLGLAL-------LECGTGEFPYNAS------------------ STE7-p2-2_Smoe_STE7-plant2 -----GGAYGFESDIWSLGLTL-------LECATGRFPYLPPGQENG------------- STE7-p2-1_Smoe_STE7-plant2 -----GGAYGFESDIWSLGLTL-------LECATGRFPYLPPGQENG------------- GK083_Glam_MEK1 -----NQPYSYVSDVWSMGLTY-------VELLTGSYPYDNV------------------ * ::*. * MAP2K7_Hsap_MEK7 ------------------------------------------------------------ MAP2K6_Hsap_MEK3 ------------------------------------------------------------ MAP2K5_Hsap_MEK5 ------------------------------------------------------------ MAP2K4_Hsap_MEK4 ------------------------------------------------------------ MAP2K3_Hsap_MEK3 ------------------------------------------------------------ MAP2K2_Hsap_MEK1 GEPHSISPR------PR---------PP------------------GR------------ MAP2K1_Hsap_MEK1 GDAAETPPR------PR---------TP------------------GR------------ MAP2K7_Mmus_MEK7 ------------------------------------------------------------ MAP2K6_Mmus_MEK3 ------------------------------------------------------------ MAP2K5_Mmus_MEK5 ------------------------------------------------------------ MAP2K4_Mmus_MEK4 ------------------------------------------------------------ MAP2K3_Mmus_MEK3 ------------------------------------------------------------ MAP2K2_Mmus_MEK1 GEPHSVSPR------PR---------PP------------------GR------------ MAP2K1_Mmus_MEK1 GDAAETPPR------PR---------TP------------------GR------------ mkk-4_Cele_MEK4 ------------------------------------------------------------ mek-2_Cele_MEK1 iela--dsl------e-------------------------------e------------ mek-1_Cele_MEK7 ------------------------------------------------------------ jkk-1_Cele_MEK7 ------------------------------------------------------------ F35C8.2_Cele_STE7-Unclassified ------------------------------------------------------------ F35C8.1_Cele_STE7-Unclassified ------------------------------------------------------------ E02D9.1_Cele_STE7-Unclassified ------------------------------------------------------------ STE7_Scer_STE7-Unclassified ------------------------------------------------------------ PBS2_Scer_STE7-Unclassified ------------------------------------------------------------ MKK2_Scer_STE7-Unclassified ------------------------------------------------------------ MKK1_Scer_STE7-Unclassified ------------------------------------------------------------ Dsor1_Dmel_MEK1 G----------------------------------------------------------- lic_Dmel_MEK3 ------------------------------------------------------------ Mkk4_Dmel_MEK4 ------------------------------------------------------------ hep_Dmel_MEK7 ------------------------------------------------------------ sek-1_Cele_MEK3 ------------------------------------------------------------ VZC374L.1_Cele_MEK4 ------------------------------------------------------------ ZC449.6_Cele_MEK4 ------------------------------------------------------------ Mek1_Ddis_STE7-Unclassified -Q-QQQQPL------QQQQQQQQQQQQPLQLQLQNLDINNSNNNIRNSNNNNNNNNNNNN 12278_Tthe_STE7-Unclassified ------------------------------------------------------------ 1557_Tthe_STE7-Unclassified ------------------------------------------------------------ 1909_Tthe_STE7-Unclassified ------------------------------------------------------------ 26687_Tthe_STE7-Unclassified ------------------------------------------------------------ MEK_Spur_MEK1 GETKN-IRK------TR------------------------------------------- MEK3_Spur_MEK3 ------------------------------------------------------------ MKK4_Spur_MEK4 ------------------------------------------------------------ MKK5_Spur_MEK5 ------------------------------------------------------------ MKK7_Spur_MEK7 ------------------------------------------------------------ CC1G_02205_Ccin_MEK1 S---SPSPSD--AQHQR---------TPTHRDSFLLSKKTAKRASKRR------------ CC1G_03368_Ccin_MEK1 GTL-SPQPAGSVSLADL---------PPP---------------KPRR------------ CC1G_01983_Ccin_STE7-Unclassified ------------------------------------------------------------ CC1G_14241_Ccin_STE7-Unclassified ------------------------------------------------------------ AqueK243_Aque_MEK1 GSL---PPR------R-------------------------------N------------ AqueK244_Aque_MEK4 ------------------------------------------------------------ AqueK245_Aque_MEK4 ------------------------------------------------------------ AqueK246_Aque_MEK4 ------------------------------------------------------------ AqueK247_Aque_MEK5 ------------------------------------------------------------ AqueK248_Aque_MEK7 ------------------------------------------------------------ STE7-p1-1_Smoe_STE7-plant1 ------------------------------------------------------------ STE7-p1-2_Smoe_STE7-plant1 ------------------------------------------------------------ STE7-p2-2_Smoe_STE7-plant2 ------------------------------------------------------------ STE7-p2-1_Smoe_STE7-plant2 ------------------------------------------------------------ GK083_Glam_MEK1 ------------------------------------------------------------ MAP2K7_Hsap_MEK7 ----------------------------CKTDFEVLTKVL--QEEPPLLPGH-------- MAP2K6_Hsap_MEK3 ----------------------------WGTPFQQLKQVV--EEPSPQLPAD-------- MAP2K5_Hsap_MEK5 --------------------------QGSLMPLQLLQCIV--DEDSPVLPV--------- MAP2K4_Hsap_MEK4 ----------------------------WNSVFDQLTQVV--KGDPPQLSNS-E------ MAP2K3_Hsap_MEK3 ----------------------------WGTPFQQLKQVV--EEPSPQLPAD-------- MAP2K2_Hsap_MEK1 ----------------PVS-GHGMDSRPAMAIFELLDYIV--NEPPPKLPN--------- MAP2K1_Hsap_MEK1 ----------------PLS-SYGMDSRPPMAIFELLDYIV--NEPPPKLPS--------- MAP2K7_Mmus_MEK7 ----------------------------CKTDFEVLTKVL--QEEPPLLPGH-------- MAP2K6_Mmus_MEK3 ----------------------------WGTPFQQLKQVV--EEPSPQLPAD-------- MAP2K5_Mmus_MEK5 --------------------------QGSLMPLQLLQCIV--DEDSPVLPL--------- MAP2K4_Mmus_MEK4 ----------------------------WNSVFDQLTQVV--KGDPPQLSNS-E------ MAP2K3_Mmus_MEK3 ----------------------------WGTPFQQLKQVV--EEPSPQLPAD-------- MAP2K2_Mmus_MEK1 ----------------PISVGHGMDSRPAMAIFELLDYIV--NEPPPKLPS--------- MAP2K1_Mmus_MEK1 ----------------PLS-SYGMDSRPPMAIFELLDYIV--NEPPPKLPS--------- mkk-4_Cele_MEK4 ------------------------------SLFDQIATVV--SGDPPILHPDSD------ mek-2_Cele_MEK1 ----------------p--nyhppsnpasmaifemldyiv--ngppptlpk--------- mek-1_Cele_MEK7 ------------------------------TEFDMMSKIL--NDEPPRLDPA-------- jkk-1_Cele_MEK7 ----------------------------NDMEFTTLTIIANLNLPSPSLREE-T------ F35C8.2_Cele_STE7-Unclassified ------------------------------------------------------------ F35C8.1_Cele_STE7-Unclassified ----------------------------GFSEFTLLSAIV--TTPAPYLERV-------- E02D9.1_Cele_STE7-Unclassified ----------------------------GLSSYEE---IT-------VEPI--------- STE7_Scer_STE7-Unclassified ----------------------------PDGILDLLQRIV--NEPSPRLPKD-------- PBS2_Scer_STE7-Unclassified ----------------------------YDNIFSQLSAIV--DGPPPRLPSD-------- MKK2_Scer_STE7-Unclassified ---------------------------QNVAPIELLTMIL--TFSP-QLKDEPEL----- MKK1_Scer_STE7-Unclassified ---------------------------ANIAPFELLMWIL--TFTP-ELKDEPES----- Dsor1_Dmel_MEK1 ---------------------QPTDEPRAMAIFELLDYIV--NEPPPKLEH--------- lic_Dmel_MEK3 ----------------------------WRTPFEQLRQVV--EDSPPRLPEG-------- Mkk4_Dmel_MEK4 ----------------------------WDSVFEQLCQVV--QGEPPRLLTSYN------ hep_Dmel_MEK7 ----------------------------CNTDFEVLTKVL--DSEPPCLPYG-E------ sek-1_Cele_MEK3 ----------------------------WKTPFEQLKQVV--KEPPPKLPME-------- VZC374L.1_Cele_MEK4 ------------------------------NQMEHIEIVV--NGDSPILLQNMH------ ZC449.6_Cele_MEK4 ----------------------------DAPILDQVRMVV--YGDPPILDSDH------- Mek1_Ddis_STE7-Unclassified NNNNNNNNNVLDISNGG-LVDSGSSVPEGMGFWVLLDCIV--KEEVPILPS--------- 12278_Tthe_STE7-Unclassified ----------------------------SNNFFEVLNNII--DFKIPPLK-N-------- 1557_Tthe_STE7-Unclassified -----------------------------KSIVQFVSNIL--QSKEPTLPDN-------- 1909_Tthe_STE7-Unclassified ---------------------------ENLSFWELLEYFN--MKPAPRLPE--------- 26687_Tthe_STE7-Unclassified ----------------------------NASFFEILAKVM--NFSIPELN-S-------- MEK_Spur_MEK1 -----------------V-GGVFSDSPRPMAIFELLNYIV--EEHPPRLPS--------- MEK3_Spur_MEK3 ----------------------------WHDMFQQLTQVV--KGTSPALPKE-------- MKK4_Spur_MEK4 ----------------------------WNSVFEQLSQVV--KGDPPRLKHN-D------ MKK5_Spur_MEK5 ---------------------------QELSPIALLQCIV--EEHPPRLPS--------- MKK7_Spur_MEK7 ------------------------------------------------------------ CC1G_02205_Ccin_MEK1 ----------------SKLTYNPDGQLSTMSIFELIHQIV--QEPSPRLP-S-------- CC1G_03368_Ccin_MEK1 ----------------QKNA-NGNGSTTKKDKRKSKGHIV--NEPAPRLTPE-------- CC1G_01983_Ccin_STE7-Unclassified ------------------------------PPIELMMYIT--NSEPPRLEDEP------- CC1G_14241_Ccin_STE7-Unclassified ----------------------------YSNVFAQLTAIV--HGPPPCLPSG--PPPPLS AqueK243_Aque_MEK1 ----------------P---YASHANAIRMPVFELLQMIF--TDDPPRLPD--------- AqueK244_Aque_MEK4 ----------------------------LRSIFGLIEMIV--KGSPPRLTSD-------- AqueK245_Aque_MEK4 ----------------------------YRNLFEQIKLVV--EGAPPQLPDD-------- AqueK246_Aque_MEK4 ------------------------------TIFDQLNAVV--SGDPPSLPPE-------- AqueK247_Aque_MEK5 ------------------------------------------------------------ AqueK248_Aque_MEK7 ----------------------------FSSEFDLLTHIV--QAPPPLLDED-------- STE7-p1-1_Smoe_STE7-plant1 -----------------------------KGPVNLMLQVM--YDPSPAPPAD-------- STE7-p1-2_Smoe_STE7-plant1 -----------------------------KGPVNLMLQVM--YDPSPAPPAD-------- STE7-p2-2_Smoe_STE7-plant2 ----------------------------YLNFYELLETIV--EQPAPVASPE-------- STE7-p2-1_Smoe_STE7-plant2 ----------------------------YLNFYELLETIV--EQPAPVASPE-------- GK083_Glam_MEK1 -----------------------------NSFWDAMNVIV--NGAPPLLKED-------- MAP2K7_Hsap_MEK7 -------------------------------MGFSGDFQSFVKDCLTKDHRKRPKYNKLL MAP2K6_Hsap_MEK3 --------------------------------KFSAEFVDFTSQCLKKNSKERPTYPELM MAP2K5_Hsap_MEK5 -------------------------------GEFSEPFVHFITQCMRKQPKERPAPEELM MAP2K4_Hsap_MEK4 ------------------------------EREFSPSFINFVNLCLTKDESKRPKYKELL MAP2K3_Hsap_MEK3 --------------------------------RFSPEFVDFTAQCLRKNPAERMSYLELM MAP2K2_Hsap_MEK1 -------------------------------GVFTPDFQEFVNKCLIKNPAERADLKMLT MAP2K1_Hsap_MEK1 -------------------------------GVFSLEFQDFVNKCLIKNPAERADLKQLM MAP2K7_Mmus_MEK7 -------------------------------MGFSGDFQSFVKDCLTKDHRKRPKYNKLL MAP2K6_Mmus_MEK3 --------------------------------KFSADFVDFTSQCLKKNSKERPTYPELM MAP2K5_Mmus_MEK5 -------------------------------GEFSEPFVHFITQCMRKQPKERPAPEELM MAP2K4_Mmus_MEK4 ------------------------------EREFSPSFINFVNLCLTKDESKRPKYKELL MAP2K3_Mmus_MEK3 --------------------------------QFSPEFVDFTSQCLRKNPAERMSYLELM MAP2K2_Mmus_MEK1 -------------------------------GVFSSDFQEFVNKCLIKNPAERADLKLLM MAP2K1_Mmus_MEK1 -------------------------------GVFSLEFQDFVNKCLIKNPAERADLKQLM mkk-4_Cele_MEK4 ------------------------------DFHYSLPLVKFINTCLTKDRRHRPKYDTLK mek-2_Cele_MEK1 -------------------------------rfftdevigfvskclrklpseratlkslt mek-1_Cele_MEK7 --------------------------------KFSPDFCQLVESCLQRDPTMRPNYDMLL jkk-1_Cele_MEK7 ------------------------------KRSFSPLFIEFLDLCLRKDVRERPEYRQLM F35C8.2_Cele_STE7-Unclassified ------------------------------------------------------------ F35C8.1_Cele_STE7-Unclassified --------------------------------TFSNN----------------------- E02D9.1_Cele_STE7-Unclassified -------------------------------DGFPESLAVLISNCLYSH-------TNFV STE7_Scer_STE7-Unclassified -------------------------------RIYSKEMTDFVNRCCIKNERERSSIHELL PBS2_Scer_STE7-Unclassified --------------------------------KFSSDAQDFVSLCLQKIPERRPTYAALT MKK2_Scer_STE7-Unclassified ------------------------------DISWSKTFRSFIDYCLKKDARERPSPRQML MKK1_Scer_STE7-Unclassified ------------------------------NIIWSPSFKSFIDYCLKKDSRERPSPRQMI Dsor1_Dmel_MEK1 -------------------------------KIFSTEFKDFVDICLKKQPDERADLKTLL lic_Dmel_MEK3 --------------------------------TFSPEFEDFIAVCLQKEYMARPNYEQLL Mkk4_Dmel_MEK4 ------------------------------GMEFSKEFVDFVNTCLIKKESDRPKYSRLL hep_Dmel_MEK7 ------------------------------GYNFSQQFRDFVIKCLTKNHQDRPKYPELL sek-1_Cele_MEK3 -------------------------------SGFSVDCQYFVKRCLEKDYNERPKYPELL VZC374L.1_Cele_MEK4 ------------------------------NLHYTDPLCRFINTCLRKNKDDRPKYVNLK ZC449.6_Cele_MEK4 --------------------------------EVSMSMKRFIALCTIKDRNLRASFDDLK Mek1_Ddis_STE7-Unclassified --------------------------------TFSKEFRSFISECLQKEPTERPTASNLL 12278_Tthe_STE7-Unclassified --------------------------------INSPEFTNFIEICLKSDQNERADITQLL 1557_Tthe_STE7-Unclassified -------------------------------GKYSAALMDFVKKCVAKEQKDRLDISDLL 1909_Tthe_STE7-Unclassified --------------------------------NYSEEMKDFVAKCFKKSPLDRPHSHDLL 26687_Tthe_STE7-Unclassified --------------------------------IKSKEFIQFVEQCTKINPKERADVVQLL MEK_Spur_MEK1 -------------------------------RAFSEEFVDFVDVCLIKNPNERADLKKLK MEK3_Spur_MEK3 --------------------------------KFSEDIQDFINKCLKKNCTERPSYTRLL MKK4_Spur_MEK4 ------------------------------FYSYSEDFISFVNKCLTKDEKYRPKYKNLL MKK5_Spur_MEK5 -------------------------------DKFSAPFVDFVNRCLQKRPGDRPKPQDLM MKK7_Spur_MEK7 ------------------------------------------------------------ CC1G_02205_Ccin_MEK1 -------------------------------DKFPADAVDLVDICLLKNPEERQTPKALL CC1G_03368_Ccin_MEK1 -------------------------------GRYPKAAESFIDACLLKDPDARQTPKDLL CC1G_01983_Ccin_STE7-Unclassified ------------------------------GVNWSEEMKDFIKQALTVDPVDRPTPKDML CC1G_14241_Ccin_STE7-Unclassified PDDDSSFEEPVLPPTLDDQDPLISPTTGRQRPGYSPFARDWVNKCMRKDAKERATYKELL AqueK243_Aque_MEK1 -------------------------------EYFDDKFKSFVALCLQKDVKKRGTLSALL AqueK244_Aque_MEK4 --------------------------------RFSGEHKDFVAQCLTKSRDSRPRYKDLN AqueK245_Aque_MEK4 -------------------------------GTFSEDFRDFVSKCLTKERDERPRYEVLN AqueK246_Aque_MEK4 --------------------------------NFTRELREFTAACLVKDSDQRPNYVQLQ AqueK247_Aque_MEK5 ------------------------------------------------------------ AqueK248_Aque_MEK7 --------------------------------KFSPNFYDFVAQCLCKDVDERPQYDKLL STE7-p1-1_Smoe_STE7-plant1 --------------------------------RFSCEFRSFVEACLRKDADTRPTAEQLL STE7-p1-2_Smoe_STE7-plant1 --------------------------------RFSCEFRSFVEACLRKDADTRPTAEQLL STE7-p2-2_Smoe_STE7-plant2 --------------------------------MFSAEFCSLISACIQKEPKDRMTAAELL STE7-p2-1_Smoe_STE7-plant2 --------------------------------MFSAEFCSLISACIQKEPKDRMTAAELL GK083_Glam_MEK1 -------------------------------AGYSPGLCDLVNAMLEKDPSKRMTAAQLL MAP2K7_Hsap_MEK7 ----------EHSFI MAP2K6_Hsap_MEK3 ----------QHPFF MAP2K5_Hsap_MEK5 ----------GHPFI MAP2K4_Hsap_MEK4 ----------KHPFI MAP2K3_Hsap_MEK3 ----------EHPFF MAP2K2_Hsap_MEK1 ----------NHTFI MAP2K1_Hsap_MEK1 ----------VHAFI MAP2K7_Mmus_MEK7 ----------EHSFI MAP2K6_Mmus_MEK3 ----------QHPFF MAP2K5_Mmus_MEK5 ----------GHPFI MAP2K4_Mmus_MEK4 ----------KHPFI MAP2K3_Mmus_MEK3 ----------EHPFF MAP2K2_Mmus_MEK1 ----------NHAFI MAP2K1_Mmus_MEK1 ----------VHAFI mkk-4_Cele_MEK4 ----------SFDFY mek-2_Cele_MEK1 ----------advff mek-1_Cele_MEK7 ----------QHPFV jkk-1_Cele_MEK7 ----------KHDFY F35C8.2_Cele_STE7-Unclassified --------------T F35C8.1_Cele_STE7-Unclassified --------------Y E02D9.1_Cele_STE7-Unclassified ----------KMFFL STE7_Scer_STE7-Unclassified ----------HHDLI PBS2_Scer_STE7-Unclassified ----------EHPWL MKK2_Scer_STE7-Unclassified ----------KHPWI MKK1_Scer_STE7-Unclassified ----------NHPWI Dsor1_Dmel_MEK1 ----------SHPWI lic_Dmel_MEK3 ----------KHSFI Mkk4_Dmel_MEK4 ----------EMPFI hep_Dmel_MEK7 ----------AQPFI sek-1_Cele_MEK3 ----------AMPFM VZC374L.1_Cele_MEK4 ----------TFSFY ZC449.6_Cele_MEK4 ----------K---T Mek1_Ddis_STE7-Unclassified ----------NHEFV 12278_Tthe_STE7-Unclassified VNTTSFSSFNEHPFL 1557_Tthe_STE7-Unclassified ----------KHEWI 1909_Tthe_STE7-Unclassified ----------NHEMV 26687_Tthe_STE7-Unclassified ----------ELPFV MEK_Spur_MEK1 ----------VHTFA MEK3_Spur_MEK3 ----------EHEFI MKK4_Spur_MEK4 ----------EYKFI MKK5_Spur_MEK5 ----------QHPFI MKK7_Spur_MEK7 --------------I CC1G_02205_Ccin_MEK1 --------VRNHPWI CC1G_03368_Ccin_MEK1 ----------KHEWI CC1G_01983_Ccin_STE7-Unclassified ----------EHPWI CC1G_14241_Ccin_STE7-Unclassified ----------EHPWL AqueK243_Aque_MEK1 ----------EHKFV AqueK244_Aque_MEK4 ----------AHSFI AqueK245_Aque_MEK4 ----------GHKFI AqueK246_Aque_MEK4 ----------EKEFF AqueK247_Aque_MEK5 --------------Y AqueK248_Aque_MEK7 ----------LHPLI STE7-p1-1_Smoe_STE7-plant1 ----------QHPFI STE7-p1-2_Smoe_STE7-plant1 ----------QHPFI STE7-p2-2_Smoe_STE7-plant2 ----------KHPFI STE7-p2-1_Smoe_STE7-plant2 ----------KHPFI GK083_Glam_MEK1 ----------KLPFC