CLUSTAL W (1.83) multiple sequence alignment TGFbR2_Hsap_STKR2 IELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPY--EEYASWKTEKDIFS--DIN- TGFbR1_Hsap_STKR1 IVLQESIGKGRFGEVWRGKWRG------EEVAVKIFSS--REERSWFREAEIYQ--TVM- MISR2_Hsap_STKR2 LCFSQVIREGGHAVVWAGQLQG------KLVAIKAFPP--RSVAQFQAERALYE--LPG- MISR2_Mmus_STKR2 LRFSQVIQEGGHAVVWAGRLQG------EMVAIKAFPP--RAVAQFRAERAVYQ--LLG- BMPR2_Mmus_STKR2 LKLLELIGRGRYGAVYKGSLD------ERPVAVKVFSF--ANRQNFINEKNIYR--VPL- BMPR1B_Mmus_STKR1 IQMVKQIGKGRYGEVWMGKWRG------EKVAVKVFFT--TEEASWFRETEIYQ--TVL- BMPR1A_Mmus_STKR1 IQMVRQVGKGRYGEVWMGKWRG------EKVAVKVFFT--TEEASWFRETEIYQ--TVL- ALK7_Mmus_STKR1 IVLQEIVGKGRFGEVWHGRWCG------EDVAVKIFSS--RDERSWFREAEIYQ--TVM- ALK4_Mmus_STKR1 IVLQEIIGKGRFGEVWRGRWRG------GDVAVKIFSS--REERSWFREAEIYQ--TVM- ALK2_Mmus_STKR1 ITLLECVGKGRYGEVWRGSWQG------ENVAVKIFSS--RDEKSWFRETELYN--TVM- ALK1_Mmus_STKR1 VALVECVGKGRYGEVWRGSWHG------ESVAVKIFSS--RDEQSWFRETEIYN--TVL- ACTR2B_Mmus_STKR2 LQLLEIKARGRFGCVWKAQLMN------DFVAVKIFPL--QDKQSWQSEREIFS--TPG- ACTR2_Mmus_STKR2 ----EVKARGRFGCVWKAQLLN------EYVAVKIFPI--QDKQSWQNEYEVYS--LPG- daf-4_Cele_STKR2 ITDFQLISKGRFGKVFKAQYTPDS-GEKRLVAVKKLNE--FQKASFLAEKRIFD--ELNE daf-1_Cele_STKR1 IRLTGRVGSGRFGNVSRGDYRG------EAVAVKVFNA--LDEPAFHKETEIFE--TRM- BMPR1A_Hsap_STKR1 IQMVRQVGKGRYGEVWMGKWRG------EKVAVKVFFT--TEEASWFRETEIYQ--TVL- BMPR1B_Hsap_STKR1 IQMVKQIGKGRYGEVWMGKWRG------EKVAVKVFFT--TEEASWFRETEIYQ--TVL- BMPR2_Hsap_STKR2 LKLLELIGRGRYGAVYKGSLD------ERPVAVKVFSF--ANRQNFINEKNIYR--VPL- ALK7_Hsap_STKR1 IVLQEIVGKGRFGEVWHGRWCG------EDVAVKIFSS--RDERSWFREAEIYQ--TVM- ALK4_Hsap_STKR1 IVLQEIIGKGRFGEVWRGRWRG------GDVAVKIFSS--REERSWFREAEIYQ--TVM- tkv_Dmel_STKR1 IQMVRLVGKGRYGEVWLAKWRD------ERVAVKTFFT--TEEASWFRETEIYQ--TVL- put_Dmel_STKR2 IQLLEQKASGRFGDVWQAKLNN------QDVAVKIFRM--QEKESWTTEHDIYK--LPR- SAX_Dmel_STKR1 VTLIECIGRGKYGEVWRGHWHG------ESIAVKIFFS--RDEESWKRETEIYS--TIL- wit_Dmel_STKR2 MNLIGMLGSGKYGTVMKGLLH------DQEVAVKIYPE--EHHQYYVNERNIYA--LPL- BABO_Dmel_STKR1 VQLCHVIGKGRFGEVWRGRWRG------ENVAVKIFSS--REECSWFREAEIYQ--TVM- TGFBR1_Mmus_STKR1 IVLQESIGKGRFGEVWRGKWRG------EEVAVKIFSS--REERSWFREAEIYQ--TVM- TGFBR2_Mmus_STKR2 IELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPY--EEYSSWKTEKDIFS--DIN- sma-6_Cele_STKR1 LTIIKTIGQGRYGEVRKALYRG------SYVAVKTFYT--TDEDSWKNERDVYQ--TNM- ALK2_Hsap_STKR1 ITLLECVGKGRYGEVWRGSWQG------ENVAVKIFSS--RDEKSWFRETELYN--TVM- ALK1_Hsap_STKR1 VALVECVGKGRYGEVWRGLWHG------ESVAVKIFSS--RDEQSWFRETEIYN--TVL- ACTR2B_Hsap_STKR2 LQLLEIKARGRFGCVWKAQLMN------DFVAVKIFPL--QDKQSWQSEREIFS--TPG- ACTR2_Hsap_STKR2 ----EVKARGRFGCVWKAQLLN------EYVAVKIFPI--QDKQSWQNEYEVYS--LPG- TGFbR1_Spur_STKR1 IVIQDCIGKGRYGEVYRGKWRG------ESVAVKIFSS--REERSWFREAEIYQ--TVM- ALK2_Spur_STKR1 INLLQQVGKGRYGEVWMGTWQG------DTVAVKIFSS--IDEKSWFRETEIYN--TVM- BMPR1_Spur_STKR1 VQLIRKIGKGRYGEVWKAKWRG------ENVAVKIYFT--AEEASWFRETDIYQ--TVL- TGFbRII_Spur_STKR2 ITLDELIGKGRFGAVWRAHWKINNGTKERTVAVKVFLE--YDSASWNVEKELFTDHSVM- ACTR2_Spur_STKR2 IQLLEIKARGRFGAVWKASCLN------DIVAVKVFPI--QDRNSWANEREIYS--LPH- BMPR2_Spur_STKR2 LKMMELVGQGRYCNVYRAALS------ENEVAVKVFTG--SSKQCYMNELDIMG--LPH- AqueK680_Aque_STKR1 ILLGESIGGGRFGQVYVGHYQG------ERYAVKKFFS--KDEQSWFHESDIYN--SVN- AqueK681_Aque_STKR1 ITIHEHLGRGTYGSISRCTYRG------NTFAVKRFTT--INESSFRRELGIYS--F-S- AqueK682_Aque_STKR1 VTKISVIGQGRFGKVWRCSYEE------KHIAMKVFKN--MHMAVFKREVEIYD--TYM- AqueK683_Aque_STKR2 ------------------------------------------LSQWKIERDIYL--TPE- AqueK684_Aque_STKR2 PEFMKIIGHGRFARVYHARMGT------RDVAIKIFNGTLQAKGSWTQEKDIYA--TER- AqueK685_Aque_STKR2 FQLIQSIGNGRFGSVWKALYE------KETVAVRVFSQ--RHRTSWQNERDIHL--LNS- AqueK686_Aque_STKR2 FQLLQPIGNGRFGSVWKALYN------NETVAVKALSL--HHKLSWQNERDIHL--LDS- : * : TGFbR2_Hsap_STKR2 --LKHENILQFLTAEERKT---ELGKQYWLITAFHAKGNLQEYLTR-HV-ISWEDLRKLG TGFbR1_Hsap_STKR1 --LRHENILGFIAADNKDNG---TWTQLWLVSDYHEHGSLFDYLNR-YT-VTVEGMIKLA MISR2_Hsap_STKR2 --LQHDHIVRFITASRGGPG--RLLSGPLLVLELHPKGSLCHYLTQ-YT-SDWGSSLRMA MISR2_Mmus_STKR2 --LQHDHIVRFITAGQGGPG--PLPSGPLLVLELYPKGSLCHYLTQ-YT-SDWGSSLRMA BMPR2_Mmus_STKR2 --MEHDNIARFIVGDERLTA--DGRMEYLLVMEYYPNGSLCKYLSL-HT-SDWVSSCRLA BMPR1B_Mmus_STKR1 --MRHENILGFIAADIKGTG---SWTQLYLITDYHENGSLYDYLKS-TT-LDAKSMLKLA BMPR1A_Mmus_STKR1 --MRHENILGFIAADIKGTG---SWTQLYLITDYHENGSLYDFLKC-AT-LDTRALLKLA ALK7_Mmus_STKR1 --LRHENILGFIAADNKDNG---TWTQLWLVSEYHEQGSLYDYLNR-NI-VTVAGMVKLA ALK4_Mmus_STKR1 --LRHENILGFIAADNKDNG---TWTQLWLVSDYHEHGSLFDYLNR-YT-VTIEGMIKLA ALK2_Mmus_STKR1 --LRHENILGFIASDMTSRH---SSTQLWLITHYHEMGSLYDYLQL-TT-LDTVSCLRIV ALK1_Mmus_STKR1 --LRHDNILGFIASDMTSRN---SSTQLWLITHYHEHGSLYDFLQR-QT-LEPQLALRLA ACTR2B_Mmus_STKR2 --MKHENLLQFIAAEKRGSN---LEVELWLITAFHDKGSLTDYLKG-NI-ITWNELCHVA ACTR2_Mmus_STKR2 --MKHENILQFIGAEKRGTS---VDVDLWLITAFHEKGSLSDFLKA-NV-VSWNELCHIA daf-4_Cele_STKR2 YPKWYKSIVEFVCAEKIG-------DEYWIVTEFHERLSLYELLKN-NV-ISITSANRII daf-1_Cele_STKR1 --LRHPNVLRYIGSDRVDT---GFVTELWLVTEYHPSGSLHDFLLE-NT-VNIETYYNLM BMPR1A_Hsap_STKR1 --MRHENILGFIAADIKGTG---SWTQLYLITDYHENGSLYDFLKC-AT-LDTRALLKLA BMPR1B_Hsap_STKR1 --MRHENILGFIAADIKGTG---SWTQLYLITDYHENGSLYDYLKS-TT-LDAKSMLKLA BMPR2_Hsap_STKR2 --MEHDNIARFIVGDERVTA--DGRMEYLLVMEYYPNGSLCKYLSL-HT-SDWVSSCRLA ALK7_Hsap_STKR1 --LRHENILGFIAADNKDNG---TWTQLWLVSEYHEQGSLYDYLNR-NI-VTVAGMIKLA ALK4_Hsap_STKR1 --LRHENILGFIAADNKDNG---TWTQLWLVSDYHEHGSLFDYLNR-YT-VTIEGMIKLA tkv_Dmel_STKR1 --MRHDNILGFIAADIKGNG---SWTQMLLITDYHEMGSLHDYLSM-SV-INPQKLQLLA put_Dmel_STKR2 --MRHPNILEFLGVEKHM-----DKPEYWLISTYQHNGSLCDYLKS-HT-ISWPELCRIA SAX_Dmel_STKR1 --LRHENILGFIGSDMTSRN---SCTQLWLMTHYYPLGSLFDHLNR-NA-LSHNDMVWIC wit_Dmel_STKR2 --MECPALLSYFGYDERCTM--DGRMEYQLVLSLAPLGCLQDWLIA-NT-LTFSECCGML BABO_Dmel_STKR1 --LRHENILGFIAADNKDNG---TWTQLWLVTDYHENGSLFDYLTT-HP-VDTNTMLNMS TGFBR1_Mmus_STKR1 --LRHENILGFIAADNKDNG---TWTQLWLVSDYHEHGSLFDYLNR-YT-VTVEGMIKLA TGFBR2_Mmus_STKR2 --LKHENILQFLTAEERKT---ELGKQYWLITAFHAKGNLQEYLTR-HV-ISWEDLRKLG sma-6_Cele_STKR1 --INHENILQFVAADIWSEE--DSMTKMLLITDYHELGSLSDYLCREET-LTTDEALRLI ALK2_Hsap_STKR1 --LRHENILGFIASDMTSRH---SSTQLWLITHYHEMGSLYDYLQL-TT-LDTVSCLRIV ALK1_Hsap_STKR1 --LRHDNILGFIASDMTSRN---SSTQLWLITHYHEHGSLYDFLQR-QT-LEPHLALRLA ACTR2B_Hsap_STKR2 --MKHENLLQFIAAEKRGSN---LEVELWLITAFHDKGSLTDYLKG-NI-ITWNELCHVA ACTR2_Hsap_STKR2 --MKHENILQFIGAEKRGTS---VDVDLWLITAFHEKGSLSDFLKA-NV-VSWNELCHIA TGFbR1_Spur_STKR1 --LRHENILGFIAADNKDNG---TWTQLILVSDYHENGSLFDYLNS-HV-IDVPGMLRMA ALK2_Spur_STKR1 --LRHENILAFFASDMTSRQ---SCTQLWLIMEYHERGSLYDYLNR-HV-LDARQMCRLA BMPR1_Spur_STKR1 --MRHTSILSFIAADIRGSG---AYTQLFLITEYHEWGSLYDFLNV-NI-LDSQSMLRLA TGFbRII_Spur_STKR2 --MRHEHIVQFISAEVRRVSVTSPTRQYWLITKYYKNGSLHDYLRQ-RS-VNWIDLCKLC ACTR2_Spur_STKR2 --MHHENLLHFIATEKHGEG---LEVEYWLISEFHHHGSLCDYLKA-NV-ISWKELCGIA BMPR2_Spur_STKR2 --MEHSNLLQYVGSGDRMGE--DGWVEHLLVVDMISKGSLMSYLRE-NT-YDWHTMCRLA AqueK680_Aque_STKR1 --LRHDNILTCFATDMLSNN---GVTELWLITQYHPRGSLFEELNR-GG-LTPETTLKFI AqueK681_Aque_STKR1 --LTQTNILTYIAADMITID---GVMECWLILQYCPRGSLYMELTS-SP-PSLETGVRMV AqueK682_Aque_STKR1 --LYHENILRFIGHDQIEF---ADTIELRLYTEYHENGTLQDYLKS-KPVFHFPECHQMA AqueK683_Aque_STKR2 --LRHESILTLLRAKRVK-D--I---GYQLVLKGSITGSLYQYLQS-HS-PDELEAAKIT AqueK684_Aque_STKR2 --LEHENILKFLYHDHRFHE---GQDTLWLIFDYHSNGSLYDYLQL-HR-LTFDELFSLC AqueK685_Aque_STKR2 --TPHENILKFISSESRGR---GPSSEYFIITEYLPLGSLHQFLRH-NT-LSWEQAWNIM AqueK686_Aque_STKR2 --TPHENILKFISSESRGR---GSSSEYFIITEYLPLGSLHQFLRH-NT-LSWEQAWNIM : . : * * . TGFbR2_Hsap_STKR2 SSLARGIAHLHSDHTP-C-G--RPKMPIVHRDLKSSNILVKN-DLTCCLCDFGLSLRLDP TGFbR1_Hsap_STKR1 LSTASGLAHLHMEIVG-----TQGKPAIAHRDLKSKNILVKK-NGTCCIADLGLAVRHDS MISR2_Hsap_STKR2 LSLAQGLAFLHEERWQ--N--GQYKPGIAHRDLSSQNVLIRE-DGSCAIGDLGLALVLPG MISR2_Mmus_STKR2 LSLAEGLAFLHEERWQ--D--GQYKPGIAHRDLSSQNVLIRE-DRSCAIGDLGLALVLPG BMPR2_Mmus_STKR2 HSVTRGLAYLHTELPRGD----HYKPAISHRDLNSRNVLVKN-DGACVISDFGLSMRLTG BMPR1B_Mmus_STKR1 YSSVSGLCHLHTEIFS-----TQGKPAIAHRDLKSKNILVKK-NGTCCIADLGLAVKFIS BMPR1A_Mmus_STKR1 YSAACGLCHLHTEIYG-----TQGKPAIAHRDLKSKNILIKK-NGSCCIADLGLAVKFNS ALK7_Mmus_STKR1 LSIASGLAHLHMEIVG-----TQGKPAIAHRDIKSKNILVKK-CDTCAIADLGLAVKHDS ALK4_Mmus_STKR1 LSAASGLAHLHMEIVG-----TQGKPGIAHRDLKSKNILVKK-NGMCAIADLGLAVRHDA ALK2_Mmus_STKR1 LSIASGLAHLHIEIFG-----TQGKSAIAHRDLKSKNILVKK-NGQCCIADLGLAVMHSQ ALK1_Mmus_STKR1 VSAACGLAHLHVEIFG-----TQGKPAIAHRDLKSRNVLVKS-NLQCCIADLGLAVMHSQ ACTR2B_Mmus_STKR2 ETMSRGLSYLHEDVPW-CRG-EGHKPSIAHRDFKSKNVLLKS-DLTAVLADFGLAVRFEP ACTR2_Mmus_STKR2 ETMARGLAYLHEDIPG-LK--DGHKPAISHRDIKSKNVLLKN-NLTACIADFGLALKFEA daf-4_Cele_STKR2 MSMIDGLQFLHDDRPY-FFG-H-PKKPIIHRDIKSKNILVKS-DMTTCIADFGLARIYSY daf-1_Cele_STKR1 RSTASGLAFLHNQIGG-SK--ESNKPAMAHRDIKSKNIMVKN-DLTCAIGDLGLSLSKPE BMPR1A_Hsap_STKR1 YSAACGLCHLHTEIYG-----TQGKPAIAHRDLKSKNILIKK-NGSCCIADLGLAVKFNS BMPR1B_Hsap_STKR1 YSSVSGLCHLHTEIFS-----TQGKPAIAHRDLKSKNILVKK-NGTCCIADLGLAVKFIS BMPR2_Hsap_STKR2 HSVTRGLAYLHTELPRGD----HYKPAISHRDLNSRNVLVKN-DGTCVISDFGLSMRLTG ALK7_Hsap_STKR1 LSIASGLAHLHMEIVG-----TQGKPAIAHRDIKSKNILVKK-CETCAIADLGLAVKHDS ALK4_Hsap_STKR1 LSAASGLAHLHMEIVG-----TQGKPGIAHRDLKSKNILVKK-NGMCAIADLGLAVRHDA tkv_Dmel_STKR1 FSLASGLAHLHDEIFG-----TPGKPAIAHRDIKSKNILVKR-NGQCAIADFGLAVKYNS put_Dmel_STKR2 ESMANGLAHLHEEIPA-SKT-DGLKPSIAHRDFKSKNVLLKS-DLTACIADFGLAMIFQP SAX_Dmel_STKR1 LSIANGLVHLHTEIFG-----KQGKPAMAHRDLKSKNILVTS-NGSCVIADFGLAVTHSH wit_Dmel_STKR2 RSITRGISHLHTELRLGD----QHKPCVAHRDINTRNVLVQA-DLSCCIADFGFALKVFG BABO_Dmel_STKR1 LSIATGLAHLHMDIVG-----TRGKPAIAHRDLKSKNILVKS-NLSCAIGDLGLAVRHVE TGFBR1_Mmus_STKR1 LSTASGLAHLHMEIVG-----TQGKPAIAHRDLKSKNILVKK-NGTCCIADLGLAVRHDS TGFBR2_Mmus_STKR2 SSLARGIAHLHSDHTP-C-G--RPKMPIVHRDLKSSNILVKN-DLTCCLCDFGLSLRLDP sma-6_Cele_STKR1 HSCICGIEHLHAAVHG-TG--SFRKPEIAHRDIKSKNIIVKR-PNVCCIADLGLALRYQN ALK2_Hsap_STKR1 LSIASGLAHLHIEIFG-----TQGKPAIAHRDLKSKNILVKK-NGQCCIADLGLAVMHSQ ALK1_Hsap_STKR1 VSAACGLAHLHVEIFG-----TQGKPAIAHRDFKSRNVLVKS-NLQCCIADLGLAVMHSQ ACTR2B_Hsap_STKR2 ETMSRGLSYLHEDVPW-CRG-EGHKPSIAHRDFKSKNVLLKS-DLTAVLADFGLAVRFEP ACTR2_Hsap_STKR2 ETMARGLAYLHEDIPG-LK--DGHKPAISHRDIKSKNVLLKN-NLTACIADFGLALKFEA TGFbR1_Spur_STKR1 LSIATGLAHLHMEIMG-----MQGKPAIAHRDIKSKNILVKR-NGQCAIADLGLAVRHDS ALK2_Spur_STKR1 LTACSGLVHLHTEITC-----NNSKPAIAHRDIKTKNILVKR-NLTCCIADLGLAVLHTQ BMPR1_Spur_STKR1 YSAANGLAHLHTEICG-----MQGKPAIAHRDVKSSNIMVRK-NGTCMIADMSLAARFLS TGFbRII_Spur_STKR2 GSAARGLAHLHAETYG-SHG--LHKVPVAHRDLKSTNILVKD-DGSCAIADFGLAIRLDP ACTR2_Spur_STKR2 FSMAKGLAYLHEDIPP-TTAIPFVKHSVAHRDFKSKNVLIKN-NTTACIADFGLACVFEA BMPR2_Spur_STKR2 QTTAAGLAHLHQVIDTQV----GLKPAVVHRDINSRNVLVNA-EGNCVIGDFGFAMQVCG AqueK680_Aque_STKR1 HSTCRGLAYLHLEITG-----TQGKPSVAHRDIKSKNILVKN-DSTCCIADFGLAVNYL- AqueK681_Aque_STKR1 YSACMGLSYLHSSLQG-YG--PIAKPRIAHRDIKSKNILMKT-AETCCIADFGLSIADSE AqueK682_Aque_STKR1 VSLSSGLTYLHKTIVA-G----KIKPGIAHRDLKSSNILVKT-DYTLCIADLGLAIKQSE AqueK683_Aque_STKR2 HSMSSGLAHLHYMESSQSHSK-YRVITIAHCNINSHNILMKE-DGTVFLSD--------- AqueK684_Aque_STKR2 LSGAAGLEHLHSVDNC---P-ETYKPAIAHRDLKSKNILVKK-DMTCCISDFGLAIKFDG AqueK685_Aque_STKR2 YSITSGITHLHSSSYYS-NGLLADKFSIAHRDIKPSNILVKSPSGQCVVADFGQAFVLDP AqueK686_Aque_STKR2 YSIASGITHLHSNSYYNSNGLLLEKYSIAHRDIKPSNILVKSVSGHCVVADLGLAFILDP : *: .** : * :... *::: : * TGFbR2_Hsap_STKR2 TL-------SVDD--------LANSGQVGTARYMAPEVLESRMNLENVE-SFKQTDVYSM TGFbR1_Hsap_STKR1 AT-------DTID--------IAPNHRVGTKRYMAPEVLDDSINMKHF-ESFKRADIYAM MISR2_Hsap_STKR2 LT-------QPPAWTPTQPQGPAAIMEAGTQRYMAPELLDKTLDLQDWGMALRRADIYSL MISR2_Mmus_STKR2 LA-------QPPALAPTQPRGPAAILEAGTQRYMAPELLDKTLDLQDWGTALQRADVYSL BMPR2_Mmus_STKR2 NRLV---RPGEED--------NAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYAL BMPR1B_Mmus_STKR1 DT-------NEVD--------IPPNTRVGTKRYMPPEVLDESLNRNHF-QSYIMADMYSF BMPR1A_Mmus_STKR1 DT-------NEVD--------IPLNTRVGTKRYMAPEVLDESLNKNHF-QPYIMADIYSF ALK7_Mmus_STKR1 IM-------NTID--------IPQNPKVGTKRYMAPEMLDDTMNLSIF-ESFKRADIYSV ALK4_Mmus_STKR1 VT-------DTID--------IAPNQRVGTKRYMAPEVLDETINMKHF-DSFKCADIYAL ALK2_Mmus_STKR1 ST-------NQLD--------VGNNPRVGTKRYMAPEVLDETIQVDCF-DSYKRVDIWAF ALK1_Mmus_STKR1 SS-------DYLD--------IGNNPRVGTKRYMAPEVLDEHIRTDCF-ESYKWTDIWAF ACTR2B_Mmus_STKR2 GK-------PP----------GDTHGQVGTRRYMAPEVLEGAINFQR--DAFLRIDMYAM ACTR2_Mmus_STKR2 GK-------SA----------GDTHGQVGTRRYMAPEVLEGAINFQR--DAFLRIDMYAM daf-4_Cele_STKR2 DI-------EQ----------SDLLGQVGTKRYMSPEMLEGATEFTP--TAFKAMDVYSM daf-1_Cele_STKR1 DA-------ASDII-------ANENYKCGTVRYLAPEILNSTMQFTVF-ESYQCADVYSF BMPR1A_Hsap_STKR1 DT-------NEVD--------VPLNTRVGTKRYMAPEVLDESLNKNHF-QPYIMADIYSF BMPR1B_Hsap_STKR1 DT-------NEVD--------IPPNTRVGTKRYMPPEVLDESLNRNHF-QSYIMADMYSF BMPR2_Hsap_STKR2 NRLV---RPGEED--------NAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYAL ALK7_Hsap_STKR1 IL-------NTID--------IPQNPKVGTKRYMAPEMLDDTMNVNIF-ESFKRADIYSV ALK4_Hsap_STKR1 VT-------DTID--------IAPNQRVGTKRYMAPEVLDETINMKHF-DSFKCADIYAL tkv_Dmel_STKR1 EL-------DVIH--------IAQNPRVGTRRYMAPEVLSQQLDPKQF-EEFKRADMYSV put_Dmel_STKR2 GK-------PC----------GDTHGQVGTRRYMAPEVLEGAINFNR--DAFLRIDVYAC SAX_Dmel_STKR1 VT-------GQLD--------LGNNPKVGTKRYMAPEVLDESIDLECF-EALRRTDIYAF wit_Dmel_STKR2 SKYEYKGEVAMAE--------TKSINEVGTLRYMAPELLEGAVNLRDCETSLKQMDVYAL BABO_Dmel_STKR1 KN-------DSVD--------IPSTHRVGTKRYMAPEVLDESMNDQHF-DSYKRADVYAF TGFBR1_Mmus_STKR1 AT-------DTID--------IAPNHRVGTKRYMAPEVLDDSINMKHF-ESFKRADIYAM TGFBR2_Mmus_STKR2 TL-------SVDD--------LANSGQVGTARYMAPEVLESRMNLENVE-SFKQTDVYSM sma-6_Cele_STKR1 DK--------ILP--------EKFNVQVGTKRYMAPELISNKLNPKDF-SQFKMADIYSM ALK2_Hsap_STKR1 ST-------NQLD--------VGNNPRVGTKRYMAPEVLDETIQVDCF-DSYKRVDIWAF ALK1_Hsap_STKR1 GS-------DYLD--------IGNNPRVGTKRYMAPEVLDEQIRTDCF-ESYKWTDIWAF ACTR2B_Hsap_STKR2 GK-------PP----------GDTHGQVGTRRYMAPEVLEGAINFQR--DAFLRIDMYAM ACTR2_Hsap_STKR2 GK-------SA----------GDTHGQVGTRRYMAPEVLEGAINFQR--DAFLRIDMYAM TGFbR1_Spur_STKR1 VT-------DTVD--------IFPNNRIGTKRYMAPEVLDDTINMNHF-DSFKRADVYSF ALK2_Spur_STKR1 RE-------DNID--------MGTNTRVGTKRYMAPELLEETMDVRCF-ESFKRVDVYAF BMPR1_Spur_STKR1 EG-------NEID--------LGQNTRLGTTRYLPPEVLDNVLMSNTF-DAFKMADMYSF TGFbRII_Spur_STKR2 QS-------STDH--------LANSGQVGTPRYMSPEALECKVNLQDIE-SFKQMDTYAL ACTR2_Spur_STKR2 GK-------NP----------GDTHGQVGTRRYMAPEVLEGAIQFKR--DAFLRIDMYAF BMPR2_Spur_STKR2 SSVV---GEGDGD--------NSTITDVGTVRYMSPEVLDGAVNLRDCECALKQVDVYAL AqueK680_Aque_STKR1 ------------N--------FNNNVQQGTKRYMPPEVIKGTIDVHSF-ESFLRADIYSF AqueK681_Aque_STKR1 D----------FQ--------SFICLKQGTNRYMAPEILNETIDVKDF-VSFLRADVYSF AqueK682_Aque_STKR1 SG-------DGVDQ-------IPANKLSGTKRYMSPEILNESLDYGRF-ICYAQSDIYSF AqueK683_Aque_STKR2 ------------------------------------------------------------ AqueK684_Aque_STKR2 VD-------MI-L--------SEAKGQVGTSRYMAPEILEGAVRFNQ--EAFLKIDIYAF AqueK685_Aque_STKR2 AA-------DDRK--------LAVSGQVGTYRYMSPEALDARVNLRDSE-SFKQIDVYAM AqueK686_Aque_STKR2 AA-------DDRK--------LAVSGQVGTYRYMSPEALDARVNLRDIE-SFKQIDMYAL TGFbR2_Hsap_STKR2 ALVLWEMTSRCNAV---------------------------------------------- TGFbR1_Hsap_STKR1 GLVFWEIARRCSIG---------------------------------------------- MISR2_Hsap_STKR2 ALLLWEILSRCPDLRPDS------------------------------------------ MISR2_Mmus_STKR2 ALLLWEILSRCSDLRPDH------------------------------------------ BMPR2_Mmus_STKR2 GLIYWEVFMRCTDL-F-------------------------------------------P BMPR1B_Mmus_STKR1 GLILWEIARRCVSG---------------------------------------------- BMPR1A_Mmus_STKR1 GLIIWEMARRCITG---------------------------------------------- ALK7_Mmus_STKR1 GLVYWEIARRCSVG---------------------------------------------- ALK4_Mmus_STKR1 GLVYWEIARRCNSG---------------------------------------------- ALK2_Mmus_STKR1 GLVLWEVARRMVSN---------------------------------------------- ALK1_Mmus_STKR1 GLVLWEIARRTIIN---------------------------------------------- ACTR2B_Mmus_STKR2 GLVLWELVSRCKAA---------------------------------------------- ACTR2_Mmus_STKR2 GLVLWELASRCTAA---------------------------------------------- daf-4_Cele_STKR2 GLVMWEVISRTKLHQ--------------------------------------------- daf-1_Cele_STKR1 SLVMWETLCRCEDGDVLP------------------------------------------ BMPR1A_Hsap_STKR1 GLIIWEMARRCITG---------------------------------------------- BMPR1B_Hsap_STKR1 GLILWEVARRCVSG---------------------------------------------- BMPR2_Hsap_STKR2 GLIYWEIFMRCTDL-F-------------------------------------------P ALK7_Hsap_STKR1 GLVYWEIARRCSVG---------------------------------------------- ALK4_Hsap_STKR1 GLVYWEIARRCNSG---------------------------------------------- tkv_Dmel_STKR1 GLVLWEMTRRCYTPVSGT-----------------------------------------K put_Dmel_STKR2 GLVLWEMVSRCDF----------------------------------------------- SAX_Dmel_STKR1 GLVLWEVCRRTISC---------------------------------------------- wit_Dmel_STKR2 GLVLWEVATRCSDFYA-------------------------------------------P BABO_Dmel_STKR1 GLILWEIARRCNMG---------------------------------------------- TGFBR1_Mmus_STKR1 GLVFWEIARRCSIG---------------------------------------------- TGFBR2_Mmus_STKR2 ALVLWEMTSRCNAV---------------------------------------------- sma-6_Cele_STKR1 ALVMWEVAIRVEVNTCEEVLTVDETSPDHSASSGIGESVSSSGNISRMHLQKTNVEGHST ALK2_Hsap_STKR1 GLVLWEVARRMVSN---------------------------------------------- ALK1_Hsap_STKR1 GLVLWEIARRTIVN---------------------------------------------- ACTR2B_Hsap_STKR2 GLVLWELVSRCKAA---------------------------------------------- ACTR2_Hsap_STKR2 GLVLWELASRCTAA---------------------------------------------- TGFbR1_Spur_STKR1 GLVLWEIGRRCQVF---------------------------------------------- ALK2_Spur_STKR1 GLVMWEIARRCEVG---------------------------------------------- BMPR1_Spur_STKR1 GMVLWEIARR-------------------------------------------------- TGFbRII_Spur_STKR2 ALILWEITSRCTLL---------------------------------------------- ACTR2_Spur_STKR2 GLVLWELVTRCTVQ---------------------------------------------- BMPR2_Spur_STKR2 GLVVWEIAMRCKDL-Y-------------------------------------------P AqueK680_Aque_STKR1 GLVMWEVCTRCHLE---------------------------------------------- AqueK681_Aque_STKR1 ALVAWEVFNRCNIEQG-------------------------------------------- AqueK682_Aque_STKR1 SLIIWEIFNCCEIDGVPR------------------------------------------ AqueK683_Aque_STKR2 ------------------------------------------------------------ AqueK684_Aque_STKR2 GLILWEM----------------------------------------------------- AqueK685_Aque_STKR2 SLVLWEVCMRYQSN---------------------------------------------- AqueK686_Aque_STKR2 SLVLWEVCMRYQSD---------------------------------------------- TGFbR2_Hsap_STKR2 G-EVKDYEPPFGSKVRE-HPCVESMKDNVLRDRGRPEIPSFWLNH-QGIQMVCETLTECW TGFbR1_Hsap_STKR1 -GIHEDYQLPYYDLVPS-DPSVEEMRKVVCEQKLRPNIPNRWQSCE-ALRVMAKIMRECW MISR2_Hsap_STKR2 --SPPPFQLAYEAELGN-TPTSDELWALAVQERRRPYIPSTWRCFATDPDGLRELLEDCW MISR2_Mmus_STKR2 --RPPPFQLAYEAELGS-NPSACELWALAVEERKRPNIPSTWSCSATDPRGLRELLEDCW BMPR2_Mmus_STKR2 GESVPDYQMAFQTEVGN-HPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIEDCW BMPR1B_Mmus_STKR1 -GIVEEYQLPYHDLVPS-DPSYEDMREIVCMKKLRPSFPNRWSSDE-CLRQMGKLMTECW BMPR1A_Mmus_STKR1 -GIVEEYQLPYYNMVPS-DPSYEDMREVVCVKRLRPIVSNRWNSDE-CLRAVLKLMSECW ALK7_Mmus_STKR1 -GVVEEYQLPYYDMVPS-DPSIEEMRKVVCDQKLRPNLPNQWQSCE-ALRVMGRIMRECW ALK4_Mmus_STKR1 -GVHEDYQLPYYDLVPS-DPSIEEMRKVVCDQKLRPNVPNWWQSYE-ALRVMGKMMRECW ALK2_Mmus_STKR1 -GIVEDYKPPFYDVVPN-DPSFEDMRKVVCVDQQRPNIPNRWFSDP-TLTSLAKLMKECW ALK1_Mmus_STKR1 -GIVEDYRPPFYDMVPN-DPSFEDMKKVVCVDQQTPTIPNRLAADP-VLSGLAQMMRECW ACTR2B_Mmus_STKR2 DGPVDEYMLPFEEEIGQ-HPSLEELQEVVVHKKMRPTIKDHWLKHP-GLAQLCVTIEECW ACTR2_Mmus_STKR2 DGPVDEYMLPFEEEIGQ-HPSLEDMQEVVVHKKKRPVLRDYWQKHA-GMAMLCETIEECW daf-4_Cele_STKR2 TDEPPNYQMPFQ-VIGF-DPTIGLMRNYVVSKKERPQWRDEIIKH--------------- daf-1_Cele_STKR1 --REAATVIPYIEWTDR-DPQDAQMFDVVCTRRLRPTENPLWKDHP-EM----------- BMPR1A_Hsap_STKR1 -GIVEEYQLPYYNMVPS-DPSYEDMREVVCVKRLRPIVSNRWNSDE-CLRAVLKLMSECW BMPR1B_Hsap_STKR1 -GIVEEYQLPYHDLVPS-DPSYEDMREIVCIKKLRPSFPNRWSSDE-CLRQMGKLMTECW BMPR2_Hsap_STKR2 GESVPEYQMAFQTEVGN-HPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIEDCW ALK7_Hsap_STKR1 -GIVEEYQLPYYDMVPS-DPSIEEMRKVVCDQKFRPSIPNQWQSCE-ALRVMGRIMRECW ALK4_Hsap_STKR1 -GVHEEYQLPYYDLVPS-DPSIEEMRKVVCDQKLRPNIPNWWQSYE-ALRVMGKMMRECW tkv_Dmel_STKR1 TTTCEDYALPYHDVVPS-DPTFEDMHAVVCVKGFRPPIPSRWQEDD-VLATVSKIMQECW put_Dmel_STKR2 AGPVGEFQLPFEAELGL-RPSLDEVQESVVMKKLRPRLLNSWRAHP-GLNVFCDTMEECW SAX_Dmel_STKR1 -GIAEEYKVPFYDVVPM-DPSFEDMRKVVCIDNYRPSIPNRWSSDS-LMTGMSKLMKECW wit_Dmel_STKR2 GQATPPYKAPYEQEVGS-HPSFDQMQALVVRHKARPLFPTGWGGG-AAAKVVRDTCEDCW BABO_Dmel_STKR1 -MIYDEYQLPYYDVVQP-DPSIEEMKKVVCIEKCRPNIPNRWHASD-VLHNMAKVMKECW TGFBR1_Mmus_STKR1 -GIHEDYQLPYYDLVPS-DPSVEEMRKVVCEQKLRPNIPNRWQSCE-ALRVMAKIMRECW TGFBR2_Mmus_STKR2 G-EVKDYEPPFGSKVRE-HPCVESMKDSVLRDRGRPEIPSFWLNH-QGIQIVCETLTECW sma-6_Cele_STKR1 SLKAKQHVPPFDGIVHN-DPNFDEMNDVICVRRIRPPPDLAWKNVP-ALNELSKLMEDSW ALK2_Hsap_STKR1 -GIVEDYKPPFYDVVPN-DPSFEDMRKVVCVDQQRPNIPNRWFSDP-TLTSLAKLMKECW ALK1_Hsap_STKR1 -GIVEDYRPPFYDVVPN-DPSFEDMKKVVCVDQQTPTIPNRLAADP-VLSGLAQMMRECW ACTR2B_Hsap_STKR2 DGPVDEYMLPFEEEIGQ-HPSLEELQEVVVHKKMRPTIKDHWLKHP-GLAQLCVTIEECW ACTR2_Hsap_STKR2 DGPVDEYMLPFEEEIGQ-HPSLEDMQEVVVHKKKRPVLRDYWQKHA-GMAMLCETIEECW TGFbR1_Spur_STKR1 -GIYEEFCLPYHPWVPM-DPPIDDMRRIVCIEKRRPPVPNRWNSHK-IMESYAKVMKECW ALK2_Spur_STKR1 -GMVADYKPPFFEYVPS-DPSFDDMRKVACIEKLRPNIPNRWTNNT-VLTSMAKLMKECW BMPR1_Spur_STKR1 ------------------------------------------------------------ TGFbRII_Spur_STKR2 K-DINEYELPFSRSLGDRRASLEMMKTLVVLRRERPPITDEWLRN-PGLTIIKNTVVDCW ACTR2_Spur_STKR2 DGPVPEYRLPFEEELGQ-GTSLEDMQEWVVVKRKRPVISDHWLKHR-GLELLCETIEECW BMPR2_Spur_STKR2 RDEMGNYQMPFEEQVGL-HPTFEDMQILVSRERKRPQFPDAWKQNSQALRSLKETIEDCW AqueK680_Aque_STKR1 -GPLADYALPFQSQVPP-DPTLDDMTEFIVGKEVIPEIPETWSNNE-LLRGMSRVMYECW AqueK681_Aque_STKR1 -GIAREYQLPYSDHLPN-NSSIEDCRRVVVEEGTRPV-TSEWSKTR-FLEKLSVTIKELW AqueK682_Aque_STKR1 -----SYQLPYCEWVPT-DPDIDQMKQCVCVNNRRPTIPDSWTESE-TLSPIAKLLDSSW AqueK683_Aque_STKR2 ------------------------------------------------------------ AqueK684_Aque_STKR2 ------------------------------------------------------------ AqueK685_Aque_STKR2 DVPVPPYQSPFFDMVGE-KPTLDQMKEIVVINKQRPLLPEKWNND-KNLKRIIKLIVEGW AqueK686_Aque_STKR2 DVPVPPYQSPFFDMVGE-KPTLEQMKEIVVNANKRPGFTGVWYSD-KNLKRIIKLIKEGW TGFbR2_Hsap_STKR2 DHDPEARLTAQCVAER--FS TGFbR1_Hsap_STKR1 YANGAARLTALRI-KK--TL MISR2_Hsap_STKR2 DADPEARLTAECV-QQ--RL MISR2_Mmus_STKR2 DADPEARLTAECV-QQ--RL BMPR2_Mmus_STKR2 DQDAEARLTAQCAE-E--RM BMPR1B_Mmus_STKR1 AQNPASRLTALRV-KK--TL BMPR1A_Mmus_STKR1 AHNPASRLTALRI-KK--TL ALK7_Mmus_STKR1 YANGAARLTALRV-KK--TI ALK4_Mmus_STKR1 YANGAARLTALRI-KK--TL ALK2_Mmus_STKR1 YQNPSARLTALRI-KK--TL ALK1_Mmus_STKR1 YPNPSARLTALRI-KK--TL ACTR2B_Mmus_STKR2 DHDAEARLSAGCV-EE--RV ACTR2_Mmus_STKR2 DHDAEARLSAGCV-GE--RI daf-4_Cele_STKR2 ---------------E--YM daf-1_Cele_STKR1 ------------------KH BMPR1A_Hsap_STKR1 AHNPASRLTALRI-KK--TL BMPR1B_Hsap_STKR1 AHNPASRLTALRV-KK--TL BMPR2_Hsap_STKR2 DQDAEARLTAQCAE-E--RM ALK7_Hsap_STKR1 YANGAARLTALRI-KK--TI ALK4_Hsap_STKR1 YANGAARLTALRI-KK--TL tkv_Dmel_STKR1 HPNPTVRLTALRV-KK--TL put_Dmel_STKR2 DHDAEARLSSSCV------M SAX_Dmel_STKR1 HQNPDVRLPALRI-KK--TI wit_Dmel_STKR2 DHDADARLTS---------L BABO_Dmel_STKR1 YPNPVARLTALRI-KK--TL TGFBR1_Mmus_STKR1 YANGAARLTALRI-KK--TL TGFBR2_Mmus_STKR2 DHDPEARLTAQCVAER--FS sma-6_Cele_STKR1 HSIPHFRHSALKL-KKEMAE ALK2_Hsap_STKR1 YQNPSARLTALRI-KK--TL ALK1_Hsap_STKR1 YPNPSARLTALRI-KK--TL ACTR2B_Hsap_STKR2 DHDAEARLSAGCV-EE--RV ACTR2_Hsap_STKR2 DHDAEARLSAGCV-GE--RI TGFbR1_Spur_STKR1 YQNGAARLTALRI-KK--TL ALK2_Spur_STKR1 CPTASARHTSLRV-KK--TL BMPR1_Spur_STKR1 -------------------C TGFbRII_Spur_STKR2 DEDPEARLT----------A ACTR2_Spur_STKR2 DQDAEARLS----------A BMPR2_Spur_STKR2 DHDAEARLT----------A AqueK680_Aque_STKR1 YHQPTARPSAYYI-RK---K AqueK681_Aque_STKR1 AERGSERPSIELLRKK--IE AqueK682_Aque_STKR1 ATQASSRISALRI-S---KI AqueK683_Aque_STKR2 -------------------F AqueK684_Aque_STKR2 -------------------L AqueK685_Aque_STKR2 DEDPEARLTAANIK-I--QL AqueK686_Aque_STKR2 DEDPEARLTAANIK-I--QL