CLUSTAL W (1.83) multiple sequence alignment NIK_Hsap ATHQ--LRLGRGSFGE-VHRMEDKQTG-FQ-----CAVKKVRLE---------------- NIK_Mmus T-HQ--PRVGRGSFGE-VHRMKDKQTG-FQ-----CAVKKVRLE---------------- COT_Mmus YRNIGSGFVPRGAFGK-VYLAQDMKTK-KR-----MACKLIPID---------------- COT_Hsap YRNIGSDFIPRGAFGK-VYLAQDIKTK-KR-----MACKLIPVD---------------- DDB0229972_Ddis ----------LGKYDK-VILVILSQQY-LQNQVNIFPIKLIDRERINL------------ DDB0229973_Ddis IKLC--EQIGSGGSGCTVHRCT--VDG-FT-----CAVKVLKLKNTSP------------ DDB0230010_Ddis FRDK--IKLGTGAFGN-VFYAIRKSDS-SP-----VAIKVLME-RTKK------------ IfkA_Ddis WKKG--SCIERKSNYS-VYRGVDEDTD-RK-----LICKIVNLNIDDRSSSSLTSLSNSN IfkA~b_Ddis FEEI--EMIGKGGFGV-VVKSRNKLDC-RY-----YAIKKIKTKGYTDSNQ--------- CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque ------EILGEGGFGT-VYACSDRYYQ-TM-----FAIKCNKHNSE--EK---------- STE-Un_a_Smoe PLFY--EEIGFGASGAEVRKCS--IRQ-LD-----SAV--VKESSD-------------- STE-Un_b_Smoe YRNR--IRIAHGAFAQ-IYKATVNEEDGPR----LVVLKTVELPKGPYEP---------- NIK_Hsap ---------------------------------------------VFRAEELMACAG-LT NIK_Mmus ---------------------------------------------VFRVEELVACAG-LS COT_Mmus ---------------------------------------------QFKPSDVEIQAC-FR COT_Hsap ---------------------------------------------QFKPSDVEIQAC-FR DDB0229972_Ddis ------------------------------------------IHQNILSNEFQLLKS-LK DDB0229973_Ddis ------------------------------------------FLVEQFISEITIMVK-LS DDB0230010_Ddis --------------------------------------------DSPIIPELYIHSA-CN IfkA_Ddis NNNSNNNNNNNNNNNNNNNNNNNNNNNNNLSIDVVELKKRLIEKVKMIQKEIESMKY-LG IfkA~b_Ddis -----------------------------------------EPLTNKLLREVTTLSR-LH CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque --------------------------------------------VRNMNLECRVLDHIGH STE-Un_a_Smoe ---------------------------------------------GGWLSELRIHCSIGE STE-Un_b_Smoe ------------------------------------------CKFFDVYSEVQILEKFLG NIK_Hsap SPRIVPLYGAVR------------------------------------------------ NIK_Mmus SPRIVPLYGAVR------------------------------------------------ COT_Mmus HENIAELYGAVL------------------------------------------------ COT_Hsap HENIAELYGAVL------------------------------------------------ DDB0229972_Ddis HSGIVNYIGMIN------------------------------------------------ DDB0229973_Ddis HQNIAKYLGHRL------------------------------------------------ DDB0230010_Ddis HSNIVTYIESYL------------------------------------------------ IfkA_Ddis NPYIIKYLGTNFQ----------------------------------------------- IfkA~b_Ddis HQFVVRYYQAWIEKS-CDSFQSLEEGNEDLSGDLETDASEDWFMQSSINSRSIISRDSYS CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque HTHITQLFGAMIDKNVSA------------------------------------------ STE-Un_a_Smoe HPNVVAFYGHQLSFESAA---S--------------------------------N----- STE-Un_b_Smoe EPKISQLLDYGL------------------------------------------------ NIK_Hsap ------------------------------------------------------------ NIK_Mmus ------------------------------------------------------------ COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis ------------------------------------------------------------ DDB0229973_Ddis ------------------------------------------------------------ DDB0230010_Ddis ------------------------------------------------------------ IfkA_Ddis ------------------------------------------------------------ IfkA~b_Ddis GLSTSNSNVGGVNNTAGGGDSVSNANSNKSMIVGNSNKKLTLSSSNTSSSSSLLSNNKSK CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque ------------------------------------------------------------ STE-Un_a_Smoe ------------------------------------------------------------ STE-Un_b_Smoe ------------------------------------------------------------ NIK_Hsap ------------------------------------------------------------ NIK_Mmus ------------------------------------------------------------ COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis ------------------------------------------------------------ DDB0229973_Ddis ------------------------------------------------------------ DDB0230010_Ddis ------------------------------------------------------------ IfkA_Ddis ------------------------------------------------------------ IfkA~b_Ddis ILNTSKSTSTNTSTSTSTSNTNKNKKISKKKKSKLSPLMKPKNKKNKNNGESEQSSSDSE CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque ------------------------------------------------------------ STE-Un_a_Smoe ------------------------------------------------------------ STE-Un_b_Smoe ------------------------------------------------------------ NIK_Hsap ------------------------------------------------------------ NIK_Mmus ------------------------------------------------------------ COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis ------------------------------------------------------------ DDB0229973_Ddis ------------------------------------------------------------ DDB0230010_Ddis ------------------------------------------------------------ IfkA_Ddis ------------------------------------------------------------ IfkA~b_Ddis NGENGMKSRIIENASDSYSDDDNNNNNNNDNNNNYHSDNESDSFSGSISMSDGNGSGYEA CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque ------------------------------------------------------------ STE-Un_a_Smoe ------------------------------------------------------------ STE-Un_b_Smoe ------------------------------------------------------------ NIK_Hsap ------------------------------------------------------------ NIK_Mmus ------------------------------------------------------------ COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis ------------------------------------------------------------ DDB0229973_Ddis ------------------------------------------------------------ DDB0230010_Ddis ------------------------------------------------------------ IfkA_Ddis ------------------------------------------------------------ IfkA~b_Ddis TDDEDIINNSGSFDENENDDDDEEDDDDEYDEEDDDYETFDFQDKSRVVSNNSKLSTSSS CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque ------------------------------------------------------------ STE-Un_a_Smoe ----------GA------------------------------------------------ STE-Un_b_Smoe ------------------------------------------------------------ NIK_Hsap ------EGPWVNIFMELLEGGSLGQL---VKEQ---------GC--LPEDR--ALYYLGQ NIK_Mmus ------EGPWVNIFMELLEGGSLGQL---IKQM---------GC--LPEDR--ALYYLGQ COT_Mmus ------WGDTVHLFMEAGEGGSVLEK---LESC---------GP--MREFE--IIWVTKH COT_Hsap ------WGETVHLFMEAGEGGSVLEK---LESC---------GP--MREFE--IIWVTKH DDB0229972_Ddis ------DNTGFGIVQEFYENGSLSDI---YNRS---------GA--FQESL--VAKYTLQ DDB0229973_Ddis ------SGNQLWLFMEFYPH-SLKDV---ITK--------RTSP--FPATE--VIWMALE DDB0230010_Ddis ------CKGHVWIILEYCDGGTVRDL---LQATCTPGNPNNLQL--FEETL--IAYIITE IfkA_Ddis -----EGQNTLYIFQEYNSTLTLQQK---ILSN---------GIG-FEESQ--VKKFTYQ IfkA~b_Ddis RKKPPKETHTLYIQMEYCSKKTLKTL---IDNV---------G-G-IAEEE--AFRLLRQ CC1G_01579_Ccin ------------VLMEYCEGGSLESINERIIEK---------NVT-VEERI--AGQVAEG AqueK223_Aque ---CVYEGQKFKMLMELATNGSLDEL---LFDPDT----NEPSG--LPFNQ--SLFYLQQ STE-Un_a_Smoe --NKKLDAPQLVIFMEYVKGGSLDNV---ITRFS------KDGCLYTPPRL--AINIAES STE-Un_b_Smoe ------ESETFVLVLKHYKC-SLRAW---RLNQGGLHSHKSGKS--FVDRLPLYLEVYAA : : :: NIK_Hsap ALEGLEYLHSRR--ILHGDVKADNVLLSSDGS------------------------HAAL NIK_Mmus ALEGLEYLHTRR--ILHGDVKADNVLLSSDGS------------------------RAAL COT_Mmus ILKGLDFLHSKK--VIHHDIKPSNIVFMST--------------------------KAVL COT_Hsap VLKGLDFLHSKK--VIHHDIKPSNIVFMST--------------------------KAVL DDB0229972_Ddis ILEALGYIHSQG--IVHRNLKSNNVLLAKGGK-------------------------VKI DDB0229973_Ddis IAKGLEFLHTQKNPIIHRDLKPGNIMCSLDDKGR--------------------VCSIRV DDB0230010_Ddis LLEGLVYLRSKG--IIHRDLKSRNILLTRKGK-------------------------VKI IfkA_Ddis LLLGLLYLHSQH--IPHRDFKSHNIFFNQSTS------------------------KMLL IfkA~b_Ddis IVEGLNHIHSQQ--IIHRDLKPANIFIDNEQ-------------------------NVKI CC1G_01579_Ccin ILQGLSYLFSQD--LIHNSLEPANILFSKGG-------------------------LVKL AqueK223_Aque ILYAVHFLHQRA--ILHLDLKCANVLLFNEGR------------------------TVKL STE-Un_a_Smoe VAQGLVWLHSRG--IIHRDIKSSNILVDLDSPDN--------------------RPVVKI STE-Un_b_Smoe VLDAVKVLEAHN--VVHYDLKCDNVLLEPVDSVISEEEFWDPTWPPSEENSHPLPFRVCL .: : : : * ..: *:. : NIK_Hsap CDFGHAVCLQPDGLGKS-----------------------------------LLTGDYIP NIK_Mmus CDFGHALCLQPDGLGKS-----------------------------------LLTGDYIP COT_Mmus VDFGLSVKMTEDV----------------------------------------YLPKDLR COT_Hsap VDFGLSVQMTEDV----------------------------------------YFPKDLR DDB0229972_Ddis SDFAIGIRSSAIE---------------------------------------PSIRFSLN DDB0229973_Ddis CDFDTSKELGNG----------------------------------------VTLK-TCI DDB0230010_Ddis ADFGLATTCS-LG---------------------------------------RG-RTRMC IfkA_Ddis SNYGGRNIKIFDHFE-------------------------------------K-L-NSLK IfkA~b_Ddis GDFGLATSGAPVSKSDD-LNSSTSNTANNINLSSSTNSTAQQTPMWDLNDENLSM-TGGV CC1G_01579_Ccin SGHPWAEIV-HQGA---------------------------------------H----TS AqueK223_Aque TDFGSAVRLDESGG--------------------------------------CHIQ-SNK STE-Un_a_Smoe CDFDSAVPVGSSSIHTCYL-----------------------------AHHGLPLTDVCV STE-Un_b_Smoe ADFGQSKASVFQGG--------------------------------------ECTV-RNR .. NIK_Hsap -GTETHMA---------------------------PEVVLG----------RSCDAKVDV NIK_Mmus -GTETHMA---------------------------PEVVMG----------KPCDAKVDI COT_Mmus -GTEIYMS---------------------------PEVILC----------RGHSTKADI COT_Hsap -GTEIYMS---------------------------PEVILC----------RGHSTKADI DDB0229972_Ddis -GYPFWTS---------------------------PEVLSM----------KPFNHKVDS DDB0229973_Ddis -GTPCYMA---------------------------AEVLNVADGG-----NSGYSLKADI DDB0230010_Ddis -GTMGRIA---------------------------PEVIRR----------EPYDTQSDI IfkA_Ddis -NLNSWISSTNNSINNINNINNNNNNNNNNINTTTTQNQ--I--------NNEIDRREDI IfkA~b_Ddis -GTPFYCC---------------------------PEILEKN--------TKHYGTKVDM CC1G_01579_Ccin -RRLYYMS---------------------------PEQIQGL---------ATSRGPSDI AqueK223_Aque GLTPYFSA---------------------------PEAIRCE----------YVSFSADI STE-Un_a_Smoe -GTPRWIA---------------------------PEVLGAMY-T-----RQQYGLEADM STE-Un_b_Smoe -GTEYVKS---------------------------PEMLKLLRTGGDASLDTCVGKAVDV . .: * NIK_Hsap WSSCCMMLHMLNGCHPWTQFF-RG--PLC-----LKI---------A----------S-E NIK_Mmus WSSCCMMLHMLNGCHPWTQYF-RG--PLC-----LKI---------A----------S-E COT_Mmus YSLGATLIHMQTGTPPWVKRYPRSAYPSY-----LYI--------IH----------K-Q COT_Hsap YSLGATLIHMQTGTPPWVKRYPRSAYPSY-----LYI--------IH----------K-Q DDB0229972_Ddis WSIGCLIMELIVGHPPFSHLGPMEAL--I-----E-I--------IN----------P-S DDB0229973_Ddis WSFAMLCFEIISLLPPYHQFQHLQSI--------EMI--------IN----------G-T DDB0230010_Ddis YSLGCLIIEMAEGTVPYGKDSSLKAL--F-----YTA--------IH----------Q-Y IfkA_Ddis INLGIVVLEMLCGSDLA-NN--QTVLIYL---AQLNLLNNQQQNQNF----------I-Q IfkA~b_Ddis YSLGIIFFEMCFQFQTQ-ME--RSNILRD-----LRD--------NL----------K-F CC1G_01579_Ccin WSAGVVLLEFVQKEFPWGSD--LSPVEIM-----MNI--------VH----------G-E AqueK223_Aque WSVLCCLVEMITGHLPWCYNGLRDPHNII-----MLA--------GH----------YCD STE-Un_a_Smoe WSFGCFISELLTLNVPYAGIGDNEIHNHIKVSVVVTI--------LSSPSHALVGQAG-E STE-Un_b_Smoe WGLGCLLYELLAAEYLLYDED--WMRFFI-----RVT--------TN----------SE- . .: NIK_Hsap PPPV---------------REIPPS---CAPLTAQAIQEGLRKEPIHRVSAAELGGKVNR NIK_Mmus PPPI---------------REIPPS---CAPLTAQAIQEGLRKEPVHRASAMELRRKVGK COT_Mmus APPL---------------EDIAGD---CSPGMRELIEAALERNPNHRPKAADL------ COT_Hsap APPL---------------EDIADD---CSPGMRELIEASLERNPNHRPRAADL------ DDB0229972_Ddis TTILP--------N--CL-DENEQS--LFSLELNQFLELCFKKEPSDRASVHDL------ DDB0229973_Ddis CPPL------------PT-DLIQPK---LLQPLIELLVTCIDLNPNHRPNASQL------ DDB0230010_Ddis --KLP--------N--PK-K--------YTKEFVDFLYLCLNPDPFKRPTPEML------ IfkA_Ddis PPPL---------------QYQLQQQ---YDLIKEIEQKTHPSSPISN-NAKDFL----- IfkA~b_Ddis PPGF---------------ESTKPD-------QTQIIRSLLSRDPTQRPSTKQL------ CC1G_01579_Ccin PPTL---------------ADKTTDDAVWSNDLKDFLKQMLVNAPSGRKTAMEL------ AqueK223_Aque AEPLK--------YFRCLVPEGIET---EDPRILELFEKVFKRNPKDRPTALKL------ STE-Un_a_Smoe RPSLTWKLDEIVLE--PA-VGGDKD---CLDALIRLYESCTELDPGKRPTAQEA------ STE-Un_b_Smoe -ELIT----------NEK-AEKVGN---F-GPVVEFIRFVLVRDPCRRPTLDEV------ . * . NIK_Hsap ALQQVGGLKSPWR NIK_Mmus ALQEVGGLKSPWK COT_Mmus -------LKHEAL COT_Hsap -------LKHEAL DDB0229972_Ddis -------LRHPWL DDB0229973_Ddis -------VQKLTK DDB0230010_Ddis -------LHHTFL IfkA_Ddis ------SLCFTIN IfkA~b_Ddis -------LESGLL CC1G_01579_Ccin -------LEHSWI AqueK223_Aque -------LEHELI STE-Un_a_Smoe -------LS--SL STE-Un_b_Smoe -------MIH--L :