CLUSTAL W (1.83) multiple sequence alignment SYK_Hsap TLEDKELGSGNFGTVKKGYYQMKK-----VVKTVAVKILKNEANDPALKDELLAEANVMQ shark_Dmel LVLDREIGHGEFGSVHSGWLLRKSGAGEESRLEVAIKMLSDE---HSNKQEFLREASVMM SYK_Mmus TLEDNELGSGNFGTVKKGYYQMKK-----VVKTVAVKILKNEANDPALKDELLAEANVMQ ZAP70_Mmus LVADIELGCGNFGSVRQGVYRMRK-----KQIDVAIKVLKQGT-EKADKDEMMREAQIMH ZAP70_Hsap LIADIELGCGNFGSVRQGVYRMRK-----KQIDVAIKVLKQGT-EKADTEEMMREAQIMH Shark_Spur IERGNEIGQGEFGSVLEGKYKEKD-----RWVKVALKTLHADHL-QTGQKEFLREAKVMC Syk_Spur LNQGDQIGKGNFGSVLKGTCMANG-----QLIPVAVKTLKADFGIPNSEPEIVREAELMA AqueK439_Aque LETQGELGAGTFGTVRQGVYRPLSG---EPPVKCALKFLKPTEELPNQKAEILREADAMA AqueK440_Aque LSLGPELGQGEFGSVLRGTYRMPD----GKSVDVAVKTLRVDAM-GHGEKEFLREAKIMM AqueK441_Aque ------------------------------------------------LDEMKREILTMY *: * * SYK_Hsap QLDNPYIVRMIGICEAE--------SWMLVMEMAELGPLNKYLQQNR-HVK--------- shark_Dmel RLEHKCIVRLIGIAKGE--------MLMMVQELAPLGSMLQYILDHGHEITA-------- SYK_Mmus QLDNPYIVRMIGICEAE--------SWMLVMEMAELGPLNKYLQQNR-HIK--------- ZAP70_Mmus QLDNPYIVRLIGVCQAE--------ALMLVMEMAGGGPLHKFLLGKKEEIP--------- ZAP70_Hsap QLDNPYIVRLIGVCQAE--------ALMLVMEMAGGGPLHKFLVGKREEIP--------- Shark_Spur GLDHPCIVKLMGVCLGP--------PMMLVQELVSQGALLDFLQN-DSI-T--------- Syk_Spur GLDHPHIVRMIGICHAA--------EMMLVLELAELGPLHKYLKKHQ-EMS--------- AqueK439_Aque MLDHPNIVRLYGICVGD--------PIRLVMELAACGPLNKFLRKHV-GFP--------- AqueK440_Aque GLHHPGIVQLIGVTKNK--------PLMLVQELVPCGALVDYLYDGKYPKPE-------- AqueK441_Aque QLDHQYITTLLGVADERHILDTIGRFPMIVMEFIDGGSLRGILNDFRPSRLQPRPIKPPP *.: *. : *: :* *: *.: : SYK_Hsap ---DKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADEN shark_Dmel ---NAELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGST SYK_Mmus ---DKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADEN ZAP70_Mmus ---VSNVAELLHQVAMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDS ZAP70_Hsap ---VSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDS Shark_Spur ---ASDLKLWATQIASGMMYLEGKKFVHRDLAARNILLENKGQAKISDFGLSRATGANND Syk_Spur ---TRNVLELMYQVAQGMCYLESRQFVHRDLAARNVLLVDETFAKISDFGMSKALGLDSQ AqueK439_Aque ---VLKIVNMIIQVAKGMEYLEKTRFVHRDLAARNVLVVDDDNVKISDFGMSRAIGGGSE AqueK440_Aque ---IMTLKLWAAEIASGMMYLEKKRFVHRDLAARNILVASSYVVKISDFGLSRAVGANSD AqueK441_Aque SDWEVRYLRYSQQIAEGMDYLGSRNVVHRDLATRNVLVVSDQHVKIADFGLARQFMENRD ::: ** ** ..******:**:*: .**:***::: . SYK_Hsap YYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAM shark_Dmel EYQFTQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKL SYK_Mmus YYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAM ZAP70_Mmus YYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEAFSYGQKPYKKMKGPEVLDF ZAP70_Hsap YYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAF Shark_Spur YYRSTTGGRWPVKWYAPESIYYGTFSHSSDVWGFGVTLWEMNSRGAQPYGEKTGAEVIKQ Syk_Spur YYVAETAGKWPLKWYAPECIYKFKFSSKSDVWSYGVTLWEALSYGKRPYASMRGQELMQF AqueK439_Aque YYRAETAGRWPLKWYAPECIYYAKFDSKSDVWSYGVTAWEAFSYGAKPYQGMRGTDIMQM AqueK440_Aque YYKASQGGRWPVKWYAPESINYGTFSHASDVWSYGVTLWEMFSYGEPPYGEMTGAEVLDF AqueK441_Aque YYRSTKRTDLPVYWYAPECLIELNFKPASDVWSFGVTLWEIFTLGRRPQEFLEHVVMQA- * *: *****.: *. ****.:** ** : * * SYK_Hsap LEK-GERMGCP----------------------AGCPREMYDLMNLCWTYDVENRPG--- shark_Dmel VDS-GERLPQP----------------------NLCPAYIYAVMQSCWKERPKDRPTFVY SYK_Mmus LEK-GERMGCP----------------------AGCPREMYDLMNLCWTYDVENRPG--- ZAP70_Mmus IKQ-GKRMECP----------------------PECPPEMYALMSDCWIYKWEDRPDF-- ZAP70_Hsap IEQ-GKRMECP----------------------PECPPELYALMSDCWIYKWEDRPDF-- Shark_Spur IEN-GHRLNRP----------------------EGCPQNVYQIMNKCWSYKPCNRPTFSQ Syk_Spur IEN-GDRLSQP----------------------DRCPDDVYSLMRRCWLSEAKDRPGFGD AqueK439_Aque LEG-NERLDRP----------------------DKCPQAIYEIMLRCWSWRPEDRPSFGE AqueK440_Aque IENRNGRLDRP----------------------PTCPLPIYHLMLNCWSLETNQRPTFAE AqueK441_Aque -Q-ADPRHGHPLQAVRKKRRETHTKLYNNRLPNIGIPDQIYRMLKETWHIDPSRRPTFSH . . * * * :* :: * ** SYK_Hsap ---------F shark_Dmel LTE-----FF SYK_Mmus ---------F ZAP70_Mmus ---------L ZAP70_Hsap ---------L Shark_Spur LND-----MF Syk_Spur IES-----VL AqueK439_Aque LVS-----TI AqueK440_Aque LYD-----FF AqueK441_Aque LSDKLSRQLL :