CLUSTAL W (1.83) multiple sequence alignment TXK_Hsap ------------------------------------------------------------ TEC_Hsap ------------------------------------------------------------ ITK_Hsap ------------------------------------------------------------ ITK_Mmus ------------------------------------------------------------ BTK_Mmus ------------------------------------------------------------ BMX_Mmus ------------------------------------------------------------ BMX_Hsap ------------------------------------------------------------ BTK_Hsap ------------------------------------------------------------ Btk29A_Dmel ------------------------------------------------------------ TEC_Mmus ------------------------------------------------------------ TXK_Mmus ------------------------------------------------------------ TEC_Spur ------------------------------------------------------------ AqueK442_Aque ------------------------------------------------------------ AqueK442~b_Aque KGQAMHYLIRIDEEKKYYIYNMHRFPTVTELIEYHKLNGGGLPTRLRQPPALLVPNQPAL AqueK443_Aque ------------------------------------------------------------ AqueK444_Aque ------------------------------------------------------------ AqueK445_Aque ------------------------------------------------------------ AqueK446_Aque ------------------------------------------------------------ AqueK447_Aque ------------------------------------------------------------ AqueK448_Aque ------------------------------------------------------------ TXK_Hsap ----------------LAFIKEIGSGQFGVVHLGEWR-SHIQVAIKAINEGSMSEEDFIE TEC_Hsap ----------------LTFMRELGSGLFGVVRLGKWR-AQYKVAIKAIREGAMCEEDFIE ITK_Hsap ----------------LTFVQEIGSGQFGLVHLGYWL-NKDKVAIKTIREGAMSEEDFIE ITK_Mmus ----------------LTFVQEIGSGQFGLVHLGYWL-NKDKVAIKTIQEGAMSEEDFIE BTK_Mmus ----------------LTFLKELGTGQFGVVKYGKWR-GQYDVAIKMIREGSMSEDEFIE BMX_Mmus ----------------ITLLKELGNGQFGVVQLGQWK-GQYDVAVKMIKEGAMSEDEFFQ BMX_Hsap ----------------ITLLKELGSGQFGVVQLGKWK-GQYDVAVKMIKEGSMSEDEFFQ BTK_Hsap ----------------LTFLKELGTGQFGVVKYGKWR-GQYDVAIKMIKEGSMSEDEFIE Btk29A_Dmel ----------------LMLMEELGSGQFGVVRRGKWR-GSIDTAVKMMKEGTMSEDDFIE TEC_Mmus ----------------LTFMRELGSGLFGVVRLGKWR-AQYKVAIKAIREGAMCEEDFIE TXK_Mmus ----------------LAFVKEIGSGQFGVVHLGEWR-AHIPVAIKAINEGSMSEEDFIE TEC_Spur ----------------LKILQELGRGQFGIVHLAKLTHNNRFVAVKRMQEGSMSEEDFID AqueK442_Aque ----------------------------KRVVAGQWR-NEVDVAIKI-MEGALNEDDLIK AqueK442~b_Aque RVSSAFDDKWRIDKSELSLGKELGSGQFKRVVAGQWR-NEVDVAIKI-MEGALNEDDLIK AqueK443_Aque ----------------LSLGDELSSGEFKRVVIGQWC-NKVDVAIKMIKEDAMNEDDFIE AqueK444_Aque ----------------LSFGKELGSGEFKRVVAGQWR-NKVDVAIKMIKEDVMNEDDFIE AqueK445_Aque ----------------LSLGKELGSGEFKKVVAGQWR-NEVDVAIKI-MEGALNEDDLIK AqueK446_Aque -------------------------------------------------------DDFIE AqueK447_Aque ----------------LSFGKELGSGEFKRVVAGQWR-NKGDIAIKMIKEDTMNEEHLIE AqueK448_Aque ----------------LSLGKELGSGQFGRVVAGQWR-NKVDVAIKMMKEGAMNEDDFIE :.::. TXK_Hsap EAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKGK-LR-KEMLLSVC TEC_Hsap EAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGH-FS-RDVLLSMC ITK_Hsap EAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGL-FA-AETLLGMC ITK_Mmus EAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRSQRGL-FA-AETLLGMC BTK_Mmus EAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHR-FQ-TQQLLEMC BMX_Mmus EAQTMMKLSHPKLVKFYGVCSKKYPIYIVTEYITNGCLLNYLKSHGKG-LE-SCQLLEMC BMX_Hsap EAQTMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKG-LE-PSQLLEMC BTK_Hsap EAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHR-FQ-TQQLLEMC Btk29A_Dmel EAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMC TEC_Mmus EAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGH-FS-RDMLLSMC TXK_Mmus EAKVMMKLSHSRLVQLYGVCIQQKPLYIVTEFMENGCLLDYLRERKGQ-LQ-KALLLSMC TEC_Spur EAKVMKELQHENLVQLYGVTSAQRPMCIVTEYMSKGCLLSYLRTHKFMLLENTAILIYMT AqueK442_Aque EAILMQKFQHDNLVKLCGVCIRQRSVYIITELMVNGSLLQYLCNNQRL-VNKTDILLDMA AqueK442~b_Aque EAILMQKFQHDNLVKLCGVCIRQRSVYIITELMVNGSLLQYLCNNQRL-VNKTDILLDMA AqueK443_Aque EAILMMKFQHDNLVKLYGVCIRQGPVYIITELMVNGSLLQYLRKNKHL-VDKTDIILDMA AqueK444_Aque EAILMLKFQHDNLVKLYGVCIRQGPVYIITELMANGCLLQYIRNNQHL-VKKTGIILDMA AqueK445_Aque EATLMEKFQHDNLVKLYGVCIGQGPVYIITELNGNGSLLQYLCNNQHL-VNKTDILLDMA AqueK446_Aque EAILMIKFQHDNLVKLYGVCIRQGPVYIITELMANGSLLQYLRNNQHL-VDNTDIILDMA AqueK447_Aque EAILMLKFQHDNLVKLYGVCIGQGPVYIITELMANGCLLQYLRNNQHL-VKKTDIMLDMA AqueK448_Aque EAKVMQKFQHDNLVKLYGVCIKQGAVYIITELMVNGCLLQYLRNNKHL-VEKTDIILDMA ** * :: * .**:: ** . .: :: * .*.* .:: . :: : TXK_Hsap QDICEGMEYLERNGYIHRDL-----------------------------AARNCLVSSTC TEC_Hsap QDVCEGMEYLERNSFIHRDL-----------------------------AARNCLVSEAG ITK_Hsap LDVCEGMAYLEEACVIHRDL-----------------------------AARNCLVGENQ ITK_Mmus LDVCEGMAYLEKACVIHRDL-----------------------------AARNCLVGENQ BTK_Mmus KDVCEAMEYLESKQFLHRDL-----------------------------AARNCLVNDQG BMX_Mmus YDVCEGMAFLESHQFIHRDL-----------------------------AARNCLVDSDL BMX_Hsap YDVCEGMAFLESHQFIHRDL-----------------------------AARNCLVDRDL BTK_Hsap KDVCEAMEYLESKQFLHRDL-----------------------------AARNCLVNDQG Btk29A_Dmel IQVSKGMTYLERHNYIHRDL-----------------------------AARNCLVGSEN TEC_Mmus QDVCEGMEYLERNSFIHRDL-----------------------------AARNCLVNEAG TXK_Mmus QDICEGMAYLERSCYIHRDL-----------------------------AARNCLVSSAC TEC_Spur QQVCFGMAYLESKGFIHRDL-----------------------------AARNCLVGDKH AqueK442_Aque IQICATMKFLEQSGFIHRNL-----------------------------PARNCQVGYSN AqueK442~b_Aque IQICATMKFLEQSGFIHRNL-----------------------------PARNCQVGYSN AqueK443_Aque LQICAAMKFFEQSGFIHRNL-----------------------------AAINCLVGDRN AqueK444_Aque IQISDGMKFFEQSGLIHRDLYMEQISNLKHKIKVTTKVAKKFQLVMINMAARNCLVGDRN AqueK445_Aque IQICAAMKFLEQSGFIHRNL-----------------------------AARNCLVGDRN AqueK446_Aque IQICAAMKFFEQSGFIHRNL-----------------------------AARNCLVGDRN AqueK447_Aque IQICDAMKFFEQSGFIHRDL-----------------------------AARNCLVGYSN AqueK448_Aque IQICAAMKFLEQSGFIHRDL-----------------------------AARNCLVGDRN ::. * ::* :**:* .* ** *. TXK_Hsap IVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTE TEC_Hsap VVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTE ITK_Hsap VIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSE ITK_Mmus VIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSE BTK_Mmus VVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSL BMX_Mmus SVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSL BMX_Hsap CVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSL BTK_Hsap VVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSL Btk29A_Dmel VVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTC TEC_Mmus VVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEIFTE TXK_Mmus VVKISDFGMARYVLDDEYISSSGAKFPVKWCPPEVFHFNKYSSKSDVWSFGVLMWEVFTE TEC_Spur IVKVADFGLTRYVMDDEYTSS-GTKFPIKWAPPEVLHYTRFSSKSDVWAFGILMWEVFSG AqueK442_Aque IVKVGGFSSARFVPDDEYEASVGVKYAVRWSPPEVITHARYSSK-DVWSYGKLLWELWSG AqueK442~b_Aque IVKVGGFSSARFVPDDEYEASVGVKYAVRWSPPEVITHARYSSK-DVWSYDILLWELWSG AqueK443_Aque IVKVGGFSSARFVPDDEYTASEGAEFPARWSAPEVITHARYSSKSDIWSYGILLWELWTG AqueK444_Aque IVKVGGFSLARFVPDDEYTASVGAKYAVKWSPPEVITHARFSSKSDIWSYGILLWELWSG AqueK445_Aque IVKVGSFSSARFVPDDEYKASVGAKYAVRWSAPEVITHARFSSKSDIWSY---------- AqueK446_Aque IVKVAGFGSARYVPDNEYTASEGTEFAVKWIAPEVITHARYSSKSDVWSYGILLWELWTG AqueK447_Aque IVKVGGFSLARFVPDDQYTASEGAKYAVKWSPPEVITHGRFSSKSDVWSYGILLWELWSS AqueK448_Aque IVKVGDFGLARFVTDDEYTASEGTKFPIKWAAPEVITHARFSSKSDVWSYGILLWELWSG :*:..*. :*:* *::* :* * ::. :* .***: . ::*** *:*:: TXK_Hsap GKMPFENKSNLQVVEAISE-GFRLYRPHLAPMSIYEVMYSCWH---EKPEGRPTFAELLR TEC_Hsap GRMPFEKYTNYEVVTMVTR-GHRLYQPKLASNYVYEVMLRCWQ---EKPEGRPSFEDLLR ITK_Hsap GKIPYENRSNSEVVEDIST-GFRLYKPRLASTHVYQIMNHCWK---ERPEDRPAFSRLLR ITK_Mmus GKIPYENRSNSEVVEDIST-GFRLYKPRLASCHVYQIMNHCWK---EKPEDRPPFSQLLS BTK_Mmus GKMPYERFTNSETAEHIAQ-GLRLYRPHLASERVYTIMYSCWH---EKADERPSFKILLS BMX_Mmus GKQPYDLYDNSEVVVKVSQ-GHRLYRPQLASDTIYQIMYSCWH---ELPEKRPTFQQLLS BMX_Hsap GKQPYDLYDNSQVVLKVSQ-GHRLYRPHLASDTIYQIMYSCWH---ELPEKRPTFQQLLS BTK_Hsap GKMPYERFTNSETAEHIAQ-GLRLYRPHLASEKVYTIMYSCWH---EKADERPTFKILLS Btk29A_Dmel GKMPYGRLKNTEVVERVQR-GIILEKPKSCAKEIYDVMKLCWS---HGPEERPAFRVLMD TEC_Mmus GRMPFEKNTNYEVVTMVTR-GHRLHRPKLASKYLYEVMLRCWQ---ERPEGRPSFEDLLR TXK_Mmus GKMPFENKSNLQVVEAISQ-GFRLYRPHLAPMTIYRVMYSCWH---ESPKGRPTFAELLQ TEC_Spur GLAPYPAMSNVEVVDQVTRHNYRMERPDHCPYQMYRIMKDC------------------- AqueK442_Aque SNNPYPAFSNIQVLDQVER-GYRLEKPKLCPYKVYALMRRSWRIGKRYPKDRPLFSGLSD AqueK442~b_Aque SNNPYPAFSNIQVLDQ-------------------------------------------- AqueK443_Aque GKIPYPAFTTPEILDGVLK-GYRLEKPKLCPSNIYDLMTRSWE---KNPFKRPSFAVLLD AqueK444_Aque GKTPYPAFTNPQALDEVSK-GYRLEKPKLCPSKVYDLMKRSWQ---K------------- AqueK445_Aque ------------------------------------------------------------ AqueK446_Aque GKTPYPAFTNPQVLDEVLR-GYRLEKPKLCPSKIYDLMKRSWQ----------------- AqueK447_Aque GKNPYLGISNPLVLDKVLS-GYRLEKPKLCPSKVYDLMKRSWQ---VNPSDRPSFAVLLD AqueK448_Aque GKTPYPAFTNPQVLDEVLR-GYRLENPKLCPPEVYDLMKKSWQ---ANPEDRPSFAVLSD TXK_Hsap AVTE TEC_Hsap T--I ITK_Hsap Q--L ITK_Mmus Q--L BTK_Mmus NILD BMX_Mmus AIEP BMX_Hsap SIEP BTK_Hsap NILD Btk29A_Dmel Q-LA TEC_Mmus T--I TXK_Mmus VLTE TEC_Spur ---W AqueK442_Aque S--L AqueK442~b_Aque ---V AqueK443_Aque Y--L AqueK444_Aque ---G AqueK445_Aque ---- AqueK446_Aque ---- AqueK447_Aque S--L AqueK448_Aque S-LK