CLUSTAL W (1.83) multiple sequence alignment LTK_Hsap MGCWGQLLVWFGAA-----G-------------AIL-----CSSPGSQETFL-------- Alk_Dmel MPQLRQLVVVLAILSLLVDPSFAQRPLIMNHTFSSLPMSQHP-SFNSWPSASGGKQLRNG LTK_Mmus MGCSHRLLLWLGAA-----G-------------TIL-----CSNSEFQTPFL-------- ALK_Mmus MGAAGFLWLLPPLLLAAASY-------------SGAATDQRAGSPASGPPLQPREPLSYS scd-2_Cele MRKRRLWWFVVLFRVTLV-G-------------AIL----------------PNETFD-- ALK_Hsap MGAIGLLWLLPLLLSTAAVG-------------SGMGTGQRAGSPAAGPPLQPREPLSYS Alk_Spur ------------------------------------------------------------ LTK_Hsap ------------RSSP-------LPLASP------------------------------- Alk_Dmel RLHEQPLPLPQPTLPVATQYEDYEAAPPGSRRDNKRRLAQMAQRPGSGNGGRRGMESLRK LTK_Mmus ------------TPSL-------LPVLVL------------------------------- ALK_Mmus RLQRKSLAVDFVVPSLFRVYARDLLLPQP-R---------SPSEPEAGGLEARGSLALDC scd-2_Cele ---------------VRRYYADRFLIEDE-ENGSSRSYY-ISAESKAKAAEQFALLAPNC ALK_Hsap RLQRKSLAVDFVVPSLFRVYARDLLLPPS------------SSELKAGRPEARGSLALDC Alk_Spur ------------------------------------------------------------ LTK_Hsap ------------------------------------------------------------ Alk_Dmel ELMNPSVGGPGGGISG-GGSGYPSYSATSSIGRIDGLGQGLGSADRYGALYDQLRQPSGM LTK_Mmus ------------------------------------------------------------ ALK_Mmus EPLL-RLLGPLPGISWADGASSPSPEAGPTLSRVLKGG-----SVRKLRRAKQLVLELGE scd-2_Cele SL-----------------------TSVKNIKLRLNGN-----DIYILLEVSNLMAN--- ALK_Hsap APLL-RLLGPAPGVSWT--AGSPAPAEARTLSRVLKGG-----SVRKLRRAKQLVLELGE Alk_Spur ------------------------------------------------------------ LTK_Hsap ------------------------------------------------------------ Alk_Dmel AAMTAGPLGGPYS-TRFPPLYAGVDDQPKRSNRKNSISELY------------------- LTK_Mmus ------------------------------------------------------------ ALK_Mmus ETILEGCIGPPEEVAAVGIL-------------QFNLSELFSWWILHGEGRLRIRLMPEK scd-2_Cele ------------------------------------------------------------ ALK_Hsap EAILEGCVGPPGE-AAVGLL-------------QFNLSELFSWWIRQGEGRLRIRLMPEK Alk_Spur ------------------------------------------------------------ LTK_Hsap --------------------------------------------SP-------------- Alk_Dmel ---------KLKKALNQADEP-----AGGVTHGNFEGDPQPSSADPLQEIKDRIRDTSPN LTK_Mmus --------------------------------------------NS-------------- ALK_Mmus KASEVGREGRLSSAIR-ASQPRLLFQIFGTGHSSMESPSETPSP-PGT----------FM scd-2_Cele -------------DIQ--------------------------------------ENTCNE ALK_Hsap KASEVGREGRLSAAIR-ASQPRLLFQIFGTGHSSLESPTNMPSPSPDY----------FT Alk_Spur ------------------------------------------------------------ LTK_Hsap ------------------------------------------------------------ Alk_Dmel ANTYAPHT-DATPSSEYEYELGVKCNFETPCSWTW-----------------------GN LTK_Mmus ------------------------------------------------------------ ALK_Mmus WNLTWTMK-DSFPFLSHRSRYGLECSFDFPCELEY-SPPLH---------------NHGN scd-2_Cele TSSFCDHRVDSTYKTYHYEQEKCNCFIET-CDEETNSTELMVLYPDCYCGKREKHCDLSK ALK_Hsap WNLTWIMK-DSFPFLSHRSRYGLECSFDFPCELEY-SPPLH---------------DLRN Alk_Spur ------------------------------------------------------------ LTK_Hsap ------------------------------------------------------------ Alk_Dmel YS--D-------G--FQVITGTELSKRNLTGLLPGPAADSI-DDANGHFLYARVNPSSRP LTK_Mmus ------------------------------------------------------------ ALK_Mmus QS--W-------S--WRHVPSEEASRMN---LLDGPEAEHSQEMPRGSFLLLNTSADS-K scd-2_Cele EKCHWTPDSDHDDLKFEVFES---SNKVLFDYMLQAGSEKAN-------------LKMNK ALK_Hsap QS--W-------S--WRRIPSEEASQMD---LLDGPGAERSKEMPRGSFLLLNTSADS-K Alk_Spur ------------------------------------------------------------ LTK_Hsap ---------------------------------------------RDPKVSAPPSI---- Alk_Dmel LNLTSPEFSTTMEKCFLEVYMHQSDMSHGLSRVVVE-LLHTAESSWVPAEILGDNVRQWT LTK_Mmus ---------------------------------------------QEQKVTPTPSK---- ALK_Mmus HTILSPWMRSSSDHCTLAVSVHRHLQPS--GRYVAQ-LLPHNEAGREILLVPTPGKHGWT scd-2_Cele VSMVSKFFRQSGFNCSLRFMHHFTHQS-STSRLVVRSILQSGEKKNLYEHWLKPASVFWV ALK_Hsap HTILSPWMRSSSEHCTLAVSVHRHLQPS--GRYIAQ-LLPHNEAAREILLMPTPGKHGWT Alk_Spur ------------------------------------------------------------ LTK_Hsap ------------------------------------------------------------ Alk_Dmel RKVYRLGRVSRDFRIVFEVVPD---LRVGQKG-HVALDNLRMVNCFPEGTKSEKCS-TSQ LTK_Mmus ------------------------------------------------------------ ALK_Mmus VLQGRVGRPANPFRVALEYIS------SGNRS-LSAVDFFALKNCSEGTSPGSKMALQSS scd-2_Cele PVQVAIGSYAEPFKISIDCETGFPPKKKKNKPFTCSIADIYFENCGEIRDPIEQCSRGDQ ALK_Hsap VLQGRIGRPDNPFRVALEYIS------SGNRS-LSAVDFFALKNCSEGTSPGSKMALQSS Alk_Spur ------------------------------------------------------------ LTK_Hsap ------------------------------------------------------------ Alk_Dmel VKCTSSKVPVCIHLPRICDITRDCDEAEDEQQSCDKIPYGGRCDFE-EDWCG-WRDSGKT LTK_Mmus ------------------------------------------------------------ ALK_Mmus FTCWNG---TVLQLGQACDFHQDCAQGEDEGQLCSKLPAGFYCNFE-NGFCG-WTQSPLS scd-2_Cele FLCSISANTRCLQNA-QCDSRIDCDDESDEM-DCGNI-NGTMCDFNGQDYCNSWYQVTNV ALK_Hsap FTCWNG---TVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYCNFE-DGFCG-WTQGTLS Alk_Spur ------------------------------------------------------------ LTK_Hsap ------------------------------------------------------------ Alk_Dmel T-------------------------LTWSRHTGS--------SPTHDTGPDGDHTMQHL LTK_Mmus ------------------------------------------------------------ ALK_Mmus P-----------------------HMPRWQVRTL---------RDAHSQG----HQGRAL scd-2_Cele TDYHERLSEPTTVAPLNKLNEVPLHLFRLQSPSAKIKEAMRGSGNMLVFD----HKPNPL ALK_Hsap P-----------------------HTPQWQVRTL---------KDARFQD----HQDHAL Alk_Spur ------------------------------------------------------------ LTK_Hsap ---------------------------------LEPASPL----------NSPG------ Alk_Dmel QNNTSGYYMLVNMNQHMNNSEKNSIIGFASNAIMVSKTFNPPPSVHGNPDSPY-RNSCVV LTK_Mmus ---------------------------------LEPASLP----------NPLG------ ALK_Mmus LLS-------------------TTDILASEGATVTSATFP----------APMKNSPCEL scd-2_Cele TRR-------------------TSALVSPELPRTN-------PEAY-DEKSPL-FKSCKL ALK_Hsap LLS-------------------TTDVPASESATVTSATFP----------APIKSSPCEL Alk_Spur ------------------------------------------------------------ LTK_Hsap ------------------------------------------------------------ Alk_Dmel RFFIHQFGKNPGSINLSVVEMKEKENITTTLWWSTKN-----QG-SDWMRAEYVLPNITS LTK_Mmus ------------------------------------------------------------ ALK_Mmus RMSWLIRGVLRGNVSLVLVENKTGKEQSRTVWHVATD-----EGLSLWQHTVLSLLDVTD scd-2_Cele RFYLCSRTYSKVWQISVISKGINPMESGRTIIYEAGYTLIPKEN-CTWERVFVNIPRQNA ALK_Hsap RMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAY-----EGLSLWQWMVLPLLDVSD Alk_Spur ------------------------------------------------------------ LTK_Hsap ------------------------------------------------------------ Alk_Dmel KYYLQ-FEARMGMRIYSDVAVDDFSLSPECFGLNIPEDHLGGYNYWDVRQ---------- LTK_Mmus ------------------------------------------------------------ ALK_Mmus RFWLQ-IVTWWGPGSRATVGFDNISISLDCYLTISGEEKMSLNSVPKSRNLFEKNPNKES scd-2_Cele GFRIGIFVTNYFPGSEEYVAIDNLSFSPTCFERDINQ---------------------ST ALK_Hsap RFWLQ-MVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKEL Alk_Spur ------------------------------------------------------------ LTK_Hsap ---------------TEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVV------VTVGAA Alk_Dmel ----NLKSPTYKDFEYTNYLELTTCDTRGMIGPSQAQCEAAYREQNKTHVLREVHVVEDQ LTK_Mmus ---------------TRGPWVFNTCGASGRSGPTQTQCDGAYTGSSVM------VTVGAA ALK_Mmus KSWANISGPT-PIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLS------VVVGSE scd-2_Cele -------------WD-IPDLFINTCGASGFEQPQNCDHNR-----ELD------GQTGHF ALK_Hsap KPGENSPRQT-PIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLS------VEVGSE Alk_Spur ------------------------------------------------------------ LTK_Hsap GQLRGVQLWRVPGPGQYLISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQ Alk_Dmel SSYKGMQKWKVPHEGHYTIIAKGASGGLGSGG-VGSSRGSVAVAILELHKNEELYFLVGQ LTK_Mmus GPLKGVQLWRVPDTGQYLISAYGAAGGKGAQNHLSRAHGIFLSAVFFLRRGEPVYILVGQ ALK_Mmus GPLKGVQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKGDTLYILVGQ scd-2_Cele LKEDGTQQWTVPVTGFYRMEICGAGGGSNSKAS--GDTGDCVTLQVHLIENLSLRMLIGQ ALK_Hsap GPLKGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQ Alk_Spur ------------------------------------------------------------ LTK_Hsap QGEDACPGGSPES--QLVCLGESRAVEEHAAMDGSE-GVPGSRRWAGGGGGGGGATYVFR Alk_Dmel QGENACIKSMGVL--KEAGCGTDHDLDLAQYSFRSKQDMVKNIYIENGAGGGGGGSYVFL LTK_Mmus QGQDACPGGSPES--QLVCLGESGE---HATTYGTE-RIPGWRRWAGGGGGGGGATSIFR ALK_Mmus QGEDACPRANQLI--QKVCVGENNVIEEEIRV---N-R--SVHEWAGGGGGGGGATYVFK scd-2_Cele MGESPCFTEHDDELRPSSC----------------S-KIS--HNY------------VYD ALK_Hsap QGEDACPSTNQLI--QKVCIGENNVIEEEIRV---N-R--SVHEWAGGGGGGGGATYVFK Alk_Spur ------------------------------------------------------------ LTK_Hsap VRA--GELEPLLVAAGGGGRAYLRPRDRG--R-------TQASPEKLENRSEAPGSGGRG Alk_Dmel LNQAKNEAVPLLVAGGGGGLGIGQYIDEDFQH------GQKAKPLQAPESGQINGEPLNK LTK_Mmus LRA--GEPEPLLVAAGGGGRSYRRRPDRG--R-------TQAVPERLETRAAAPGSGGRG ALK_Mmus MKD--GVPVPLIIAAGGGGRAYGAKTET-------------FHPERLESNSSVLGLNGNS scd-2_Cele GKRG--------AAVGYGASAIHVKPDQRCNETCKAVSHTDFIVERRDNR--CPGEKG-- ALK_Hsap MKD--GVPVPLIIAAGGGGRAYGAKTDT-------------FHPERLENNSSVLGLNGNS Alk_Spur ------------------------------------------------------------ LTK_Hsap GAAGGGGGWTS---RAPSPQAGRSLQEGAEGGQGCSEAWATLGW----AAAGGFGGGGGA Alk_Dmel KTAGPGGGWRAKEDQALSPTYGAALLQGGRGGHSCYVELADNGTSVHRHGQGGFGGGGGG LTK_Mmus GAAGGGSGWTS---RAHSPQAGRSPREGAEGGEGCAEAWAALRW----AAAGGFGGGGGA ALK_Mmus GAAGGGGGWND---NTSLLWAGKSLLEGAAGGHSCPQAMKKWGW----ETRGGFGGGGGG scd-2_Cele ------------------------------------------ES----TVFGGFGGGGNS ALK_Hsap GAAGGGGGWND---NTSLLWAGKSLQEGATGGHSCPQAMKKWGW----ETRGGFGGGGGG Alk_Spur ------------------------------------------------------------ LTK_Hsap CTA-GGGGGGYRGGDASETDNLWADGEDGVSFIHPSSELF---LQPLAVTENHGEVEIRR Alk_Dmel CNT-GGGGGGYAGGDVYLTE---SNGEGGSSYISPSRSLREISEIHAGASSGPGAIIIIP LTK_Mmus CAA-GGGGGGYRGGDTSESDLLWADGEDGTSFVHPSGELY---LQPLAVTEGHGEVEIRK ALK_Mmus CSS-GGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILY---TPALKVMEGHGEVNIKH scd-2_Cele CGMLGGSGAGYQAGNPFGKSR-ARSGSSNVSIDFSKSPIY---YQSERLDEGYIKIAFCR ALK_Hsap CSS-GGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILY---TPALKVMEGHGEVNIKH Alk_Spur ------------------------------------------------------------ LTK_Hsap HLNCSHCPLRDCQWQAE-LQLAECLCPEGMELAVDNVTCMDLHKPP--G----------- Alk_Dmel AIEGCGCDYRCVALDEF-RSKVRCICPDGWSLKRDNHTACEIREEAGKS----------- LTK_Mmus HPNCSHCPFKDCQWQAE-LWTAECTCPEGTELAVDNVTCMDLPTTA--S----------- ALK_Mmus YLNCSHCEVDECHMDPE-SHKVICFCDHGTVLADDGVSCIVSPTPEPHL----------- scd-2_Cele K-RCE--PPTVCRFRKDYFEEEYCGCPDGSNVTDTEEACA-FPLVCPSSSTNQYRNFTYE ALK_Hsap YLNCSHCEVDECHMDPE-SHKVICFCDHGTVLAEDGVSCIVSPTPEPHL----------- Alk_Spur ------------------------------------------------------------ LTK_Hsap ---------------------PLVLMVAVVATSTLS-LLMVCGVLILVKQKKWQGLQE-- Alk_Dmel ---------------------SFQYLVSILMISLAVLFICIAALIFMLYNRYQRKKQSKK LTK_Mmus ---------------------PLILMGAVVAALALS-LLMMCAVLILV-NQKCQGLWG-- ALK_Mmus ---------------------PLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQ scd-2_Cele PFCLCNNGKEIYDVYNDTCEEIQIWTLYNITFLIFAALTI-IGALFVVYHYRNREKQMKQ ALK_Hsap ---------------------PLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQ Alk_Spur ------------------------------------------------------------ LTK_Hsap --MRLPSPELELSKLRTSA---IRTAPNPYYC----QVGLGPAQSWPLPPGVTEVSPANV Alk_Dmel RHKMLVEQDLQLTRLRNNIDDSNLNNFNPNYG----CDGILNGH--IDVNSLPQVARDSL LTK_Mmus --TRLPGPELELSKLRSSA---IRTAPNPYYC----QVGLSPAQPWPLPPGLTEVSPANV ALK_Mmus --MELQSPEYKLSKLRTST---IMTDYNPNYC----FAGKTSS-----ISDLKEVPRKNI scd-2_Cele -------EILDLTQMKS-----------PDYLYDDIYFGRTT--RKAALDSLPSISRDSI ALK_Hsap --MELQSPEYKLSKLRTST---IMTDYNPNYC----FAGKTSS-----ISDLKEVPRKNI Alk_Spur ------------------------------------------------------------ LTK_Hsap TLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPE--LCSPQDELDFLMEALIISKF Alk_Dmel QLVNALGKGAFGEVYMALYRHRDGDAVEMGVAVKTLRE--DPKREKEEDFLKEAAIMAKF LTK_Mmus TLLRALGHGAFGEVYEGLVTGLPGDSSPLPVAIKTLPE--LCSHQDELDFLMEALIISKF ALK_Mmus TLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPE--VCSEQDELDFLMEALIISKF scd-2_Cele ERGRVLGRGNFGEVYYGEYSGV-------KLAVKMISRTFSASQASQSDFCNEALCMGTF ALK_Hsap TLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPE--VCSEQDELDFLMEALIISKF Alk_Spur ---------------------------------QTLPE--HCTEQDELDFLMEALIMGNF : : . . .: ** ** :..* LTK_Hsap RHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHLG--QPSPLVMRDLLQLAQD Alk_Dmel NHPNMVHLIGVCFDRQPYYIVLELLAGGDLQKFLRENRNTPE--RPSLLTMKDLLFCALD LTK_Mmus SHQNIVRCVGLSFRSAPRLILLELMSGGDMKSFLRHSRPHPG--QLAPLTMQDLLQLAQD ALK_Mmus NHQNIVRCIGVSLQALPRFILLELMAGGDLKSFLRETRPRPN--QPTSLAMLDLLHVARD scd-2_Cele VDENVVRLIGIDFEKVPYMIALEYMEGGDLLSFVKECRPNQVSLNPFQLAMSDLIKICCD ALK_Hsap NHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPS--QPSSLAMLDLLHVARD Alk_Spur DHPNVVSLLGICFKEKPLFIVLEYMEGGELKQFLRDIRPTEE--KPSSITMKDLLQITQD . *:* :*: : * * ** : **:: .*::. * . :.* **: * LTK_Hsap IAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDI-YRASYYRRGDRALL Alk_Dmel VAKGCRYMESKRFIHRDIAARNCLLSSKGPGRVVKIADFGMSRDI-YRSDYYRKGGKAML LTK_Mmus IAQGCHYLEENHFIHRDIAARNCLLSCSGASRVAKIGDFGMARDI-YQASYYRKGGRTLL ALK_Mmus IACGCQYLEENHFIHRDIAARNCLLTCPGAGRIAKIGDFGMARDI-YRASYYRKGGCAML scd-2_Cele VAAGCKCLETFGYVHRDIAARNILLTTRGPQRVAKIADFGMAKEITYGTEYYRINGRTMM ALK_Hsap IACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDI-YRASYYRKGGCAML Alk_Spur VAQGCRYLESRRFIHRDIAARNILLTTKESGRAAKIADFGMARDI-YRADYYRKGGQALL :* **: :* ::******** **: . * .**.****:::* * :.*** .. ::: LTK_Hsap PVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPP Alk_Dmel PIKWMPPEAFLDGIFTSKTDVWSFGILLWEVFSLGRSPYPGQHNTQVMELVVRGGRLGSP LTK_Mmus PVKWMPPEALLEGLFTSKTDSWSFGVLLWEIFSLGYMPYPGHTNQEVLDFIATGNRMDPP ALK_Mmus PVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPP scd-2_Cele PIKWTPPEAFIDGVFTTKSDIWSFGVLCWEVFSLGVVPYPNRRNEEVMLMLTEGARLEYP ALK_Hsap PVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPP Alk_Spur PVKWMPPEAFQDGIFTSKTDVWAYGVLLWEIISLGFMPYPGMSNQEVIQFVSAGERMNPP *:** ****: :*:**:*:* *::*:* **::*** ***. * :*: :: * *: * LTK_Hsap RGCPGPVYRIMTQCWQHEPELRPSFASILERLQYCTQDPDVLNSLLPMELGPTPEEEGTS Alk_Dmel TECPVSIYKVMADCWNPTPEDRPTFITLLEHLTACTQDASIMNAPLPNILGPTASERDDT LTK_Mmus RNCPGPVYRIMTQCWQHQPELRPDFGSILERIQYCTQDPDVLNSPLPVEPGPILEEEEAS ALK_Mmus KNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPVVEEEEKV scd-2_Cele YGIPTRVYQLMRDCWKTAAADRPKFVDVVEIFQDIQDDPASVGMPFPIHPAV--RATFA- ALK_Hsap KNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKV Alk_Spur RSCPQPVFNLMSQCWRHIPEDRPPFTTILESINYCLQDPDVLETPLPKVLTE--RKKQLT * ::.:* :**. . ** * ::* : :*. : :* LTK_Hsap GLGNRSLECLR----------------------------P-----------------PQ- Alk_Dmel VIRPPNGEEFCLAVPDYLVPLPPGGSNNPSMASGSGYVPELQRQQ-MSSCT-PPAVT--- LTK_Mmus RLGNRSLEGLR----------------------------S-----------------PK- ALK_Mmus PMRPKDPEGMP----------------------------PLLVSPQPAKHEEAS-AAPQ- scd-2_Cele ----------------------------------------------HSQST-PVSV---- ALK_Hsap PVRPKDPEGVP----------------------------PLLVSQQAKREEERSPAAPP- Alk_Spur IMRPPDPKRSP----------------------------VLRVERVIRSCE-PSPFSSQR LTK_Hsap --PQELSP--EKLKSWGGSPLGPWL--------------------------------S-- Alk_Dmel -SPAAPHPRPV------------------------------------------------- LTK_Mmus --PLELSS--QNLKSWGGGLLGSWL--------------------------------P-- ALK_Mmus --PAALTAPGPSVKKPPGAGAGAGAGAGAGPVPRGA------ADRGHVNMAFSQPNPP-- scd-2_Cele ETPMTAMT-----EISLN-STFTDASTVKVS------AQQDMQDR--------------- ALK_Hsap --PLPTTSSGKAAKKPTAAEI-------SVRVPRGPA-----VEGGHVNMAFSQSNPP-- Alk_Spur VSPLHHTPSPTHQPTWVGQ-TGE------GSSQQGLHHQDEGIDRTYNGKRFQDHSPLNS * . LTK_Hsap S---------G----------------LKPLKSRGLQPQNLWNPTYR------------- Alk_Dmel ---------------------------------------ENIAPTSGD-----CWETSFI LTK_Mmus S---------G----------------LKTLKPRCLQPQNIWNPTYGS------WTPR-- ALK_Mmus P---------E----------------LHKGPGSRNKPTSLWNPTYGS------WFTE-- scd-2_Cele I---------Q----------------LHELMLTREHPYTSELTSYVV------NSIR-- ALK_Hsap S---------E----------------LHKVHGSRNKPTSLWNPTYGS------WFTE-- Alk_Spur SSILLTNKSYGFRSLARDITGDAKDRTCHNGVTENSSQMNNLSPTRHVNETEQSSEMSTL .: LTK_Hsap ------------------------------------------------------------ Alk_Dmel LPNSKVEPPVVGSGHDVPLAGGEEAKLISLDTPQP-----------------------TP LTK_Mmus GPQGE------------------------------------------------------- ALK_Mmus KPAKKTHPPPGAEPQARAG--AAEGG---------------------------------- scd-2_Cele K--DLA-------------RVQYENGLTS--VPQP-----------------------EY ALK_Hsap KPTKKNNPIAKKEPHDRGN-LGLEGS---------------------------------- Alk_Spur LHVGRSGSSRSDSLSDIPAGSNQEPGWYPDPTCKPKRSASMRHGEASREHTKSPLTRGLS LTK_Hsap ------------------------------------------------------------ Alk_Dmel TTIQPPLSFA----------------SQLDGITLDPSALTKSLPNGNAKQSYANVQVKNE LTK_Mmus ------------------------------------------------------------ ALK_Mmus -WTGPG--AGPRRAEAALLLEPSALSATMKEVPL---FRLRHFPCGNVNYGYQQQGLPLE scd-2_Cele L--------SPENNDESVQLIPQSNTVTDQTPPT---SLIDLNRL-----GVQNTGP--- ALK_Hsap -CTVPPNVATGRLPGASLLLEPSSLTANMKEVPL---FRLRHFPCGNVNYGYQQQGLPLE Alk_Spur WTQRPPQSQDNQNPQDTNIH----RSTSLPGIPV---IVTTPNPMSKDNIAFKLQ----- LTK_Hsap ------------------------------------------------------------ Alk_Dmel AEAKVINGVV-GNGTVMNGDVST-GSGGAD-----------SPFTIQGYAERYKDNN--- LTK_Mmus -------------------------------------------------DTGIEHCNGSS ALK_Mmus ATAA--P------G-----------------------------------DTMLKSKN--- scd-2_Cele ---------------TLHRP----DSLNFN-------------------D-PYS---SVP ALK_Hsap AATA--P------G-----------AGHY-------------------EDTILKSKN--- Alk_Spur LKTAT-NGSFSRAG-SLKKKLSKKLSRDYRNTDSEPLCWRHIPEDRPPFTTILESIN--- LTK_Hsap ------------S Alk_Dmel NHSE------ISC LTK_Mmus SSSIPG-----IQ ALK_Mmus KVTQP------GP scd-2_Cele LLE------CQTR ALK_Hsap SMNQP------GP Alk_Spur YCLQVSAGLDLMI