CLUSTAL W (1.83) multiple sequence alignment TNK1_Hsap ML---------------------------------P----E----A-GS----LWLLKLL Ack_Dmel MRGPLTARHQNQQPSRQLLIWRE----------MTSTSAVDGGLGS-ET----AWLEDLL PR2_Dmel MVKR-------------------------------E----E----APGGG-SQVALD--- ACK_Mmus MGERSAYQR---------LARGEEGQQRLGSSSMQP----E----E-GT----GWLLELL kin-25_Cele MA---------------------------------S----T----S-GALVD-DNVLEVL ark-1_Cele MREE-------------------------------P----T----A-GTA-D-ATLNKLL TNK1_Mmus ML---------------------------------P----E----A-SS----LWLLRLL ACK_Hsap MGERSAYQR---------LAGGEEGPQRLGGGRMQP----E----E-GT----GWLLELL Ack1_Spur ------------------------------------------------------------ Ack2_Spur MKET-------------------------------E----E----G-GD----GRIHALV Ack3_Spur ---------------------------------------------E-GA----QWLEELL TNK1_Hsap RDIQLAQFYWPILEELNVTRPEHFDFVKPEDLDGIGMGRPAQRRLSEALKRLRSGPKSKN Ack_Dmel REVQLEQFLDRIRDDLQVTRLAHFDYVLPDDLERCGLGKPAIRRLMEAVRKKKAHQWRKN PR2_Dmel ------------------------------------------------------------ ACK_Mmus SEVQLQQYFLRLRDDLNITRLSHFEYVKNEDLEKIGMGRPGQRRLWEAVKRRKAMCKRKS kin-25_Cele RKAQLDAFISQFVFLFNVRRFDHFSHVRDKDMLEIGMQQVQIRQLREQILKMSREMWNRS ark-1_Cele QAADLSGYESDLRRKLKLRNAADLQYVEEVDLLSVGMSRPEQKRLRKEYTKM-------- TNK1_Mmus RDVQLAQFYRPILEELNVTRPEHFDFVRPEDLDNIGMGRPAQRRLNEALKRYRSGVKSKN ACK_Hsap SEVQLQQYFLRLRDDLNVTRLSHFEYVKNEDLEKIGMGRPGQRRLWEAVKRRKALCKRKS Ack1_Spur ------------------------------------------------------------ Ack2_Spur L---------------NV--------VKPG----------------DSVNRSRAANSSQ- Ack3_Spur EETQLQKFLTKIHDDLQVSRLDHFQYVRTEDLEKIGMGRPAARRLLEAVKRRRRRSGSQS TNK1_Hsap WVYKILGGFA------PEHKEPTLPSDSP--R--HLPEPEGGLKCLIPEGAVCRGELLGS Ack_Dmel ILSKLIGGGK----QPSSKKQSS-----A--ARESSQGNGTQLTCLIHEKDITMGLKLGD PR2_Dmel ------GS------SASA-CSSL-AAKNG--A--SSPSKVPNNKHIIPADSISVNKQLGT ACK_Mmus WMSKVFSGKRLEAEFPSQHSQSTFRKPSPTPGSLPGEGTLQSLTCLIGEKDLRLLEKLGD kin-25_Cele DPKQV-----------------YIQADQS-----MPAQNSIDEKALIPNEQIKLYELIGE ark-1_Cele FPSGIFGKVK----KAFKRAESL-DRKTS--N--SVANQDDNDHHVIPIEKITLCKELGQ TNK1_Mmus WVYKILGGFA------PEQKEIPPRSDSP--L--CFHEPEGGLKCLIPEGAVRRGELLGS ACK_Hsap WMSKVFSGKRLEAEFPPHHSQSTFRKTSPAPGGPAGEGPLQSLTCLIGEKDLRLLEKLGD Ack1_Spur ------------------------------------------------------------ Ack2_Spur ---------------P-------ATQPLPSGV-TSTRQNMESLTCLISESELTLHEKLGN Ack3_Spur ILGRVAVVKRLTVRYPTAHNKSFNRKPSGFDRRLNGIGDIRDVTALIAEREEERERKSGR TNK1_Hsap GCFGVVHRGLWTL-PSGKS-VPVAVKSLRVGPEGPMGTELGDFLREVSVMMNLEHPHVLR Ack_Dmel GSFGVVRRGEWSASPAGKV-IPVAVKVLKSDNLTQ-PGIIDDFFREVQAMHALDHANLVR PR2_Dmel GEFGIVQQGVWSN--GNER-IQVAIKCLCRERMQS---NPMEFLKEAAIMHSIEHENIVR ACK_Mmus GSFGVVRRGEWDA-PAGKT-VSVAVKCLKPDVLSQ-PEAMDDFIREVNAMHSLDHRNLIR kin-25_Cele GSFAVVKRGTWTQ-SNGTH-VNVAVKILRD--I-S-PNIMDDLRVEASHLLKLQHPSLIR ark-1_Cele GEFGSVWQAGWKN-SAGSDVIQVAVKCVGSDKLLA---TSSSFLQEAAIMTRMRHEHVVR TNK1_Mmus GCFGVVHRGLWTL-PSGQS-IPVAVKSLRVGPEGPMGTELGDFLREVSVMMKLEHPHVLR ACK_Hsap GSFGVVRRGEWDA-PSGKT-VSVAVKCLKPDVLSQ-PEAMDDFIREVNAMHSLDHRNLIR Ack1_Spur --------------------IPVAVKCLSPEKLSL-DKCQQDFLKEAAIMHSLNHEHLVK Ack2_Spur GSFGVVRRGDWKT-PRGKR-VEVAVKCLRSEMVNQ-PGFFEDFVKEVNTMHLLDHPHLVR Ack3_Spur AKFGMVKHEKWSL-CTGSF-STVSMRCLRYEVAGS-EELVDGFLPNFSYMYLVEPEELIR *::: : : : : : ::: TNK1_Hsap LHGLVLG--QPLQMVMELAPLGSLHARLTAPAPTPP-LLVALLCLFLRQLAGAMAYLGAR Ack_Dmel LYGVVLS--QPMMMITELAERGSLLDTLRKQCR--H-TSLTIIWNWSVQIVTGMAYLEQK PR2_Dmel LYGVVLAT-DSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQICNGMRYLEQK ACK_Mmus LYGVVLT--LPMKMVTELAPLGSLLDRLRKHQG--H-FLLGTLSRYAVQVAEGMAYLESK kin-25_Cele LYGIVR---QPAMMVFELCEGGSLLDRLRDDK-KAI-LLVSRLHDYCMQIAKALQFLESK ark-1_Cele LYGVVLDT-KKIMLVSELATCGSLLECLHKPALRDS-FPVHVLCDYAEQIAMGMSYLELQ TNK1_Mmus LHGLVLG--QPLQMVMELAPLGSLHARLTAPAPTPP-LPVALLCLFLRQLAGAMAYLGSC ACK_Hsap LYGVVLT--PPMKMVTELAPLGSLLDRLRKHQG--H-FLLGTLSRYAVQVAEGMGYLESK Ack1_Spur LYGVVLDVDSSLMLVTEFAPLRSLAENMKQEALKPA-FPITLLLDFSVQITDAMRYLHMS Ack2_Spur LYGVVLS--SPLKMVTELAPLGALVDRLREDPS--K-FLISTLSAFALQIASGMSFLEYK Ack3_Spur FWGYE------------------------------------------------------- : * TNK1_Hsap GLVHRDLATRNLLLASP----RTIKVADFGLVRPLGGARGRYV--MGGPRPIPYAWCAPE Ack_Dmel RFLHRDLACRNVLLAAG----NKIKIGDFGLMRALPQEDDCYV--MSEHKKVPFPWCAPE PR2_Dmel RLIHRDLAARNILVFSK----DKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPE ACK_Mmus RFIHRDLAARNLLLATR----DLVKIGDFGLMRALPQNDDHYV--MQEHRKVPFAWCAPE kin-25_Cele HCVHRDVAARNILLARD---ERTVKICDFGLMRALKENEQMYT--MAPQKKVPFAWCPPE ark-1_Cele RLIHRDLAARNVLVFSP----KLVKISDFGLSRSLGIGEDYYRSEFTPNLKLPIAWCAPE TNK1_Mmus GLVHRDLATRNLLLASP----RMIKVADFGLVRPLGGARGRYV--MGGPRPIPYAWCAPE ACK_Hsap RFIHRDLAARNLLLATR----DLVKIGDFGLMRALPQNDDHYV--MQEHRKVPFAWCAPE Ack1_Spur NIIHRDLAARNILLFVDDEGNKKAKISDFGLSRRLLLGENYR-SEMRPNLKLPLAWMPVE Ack2_Spur RFIHRDLAARNILLASM----QKVKIGDFGLMRALPSATNYYI--MTEHNQVPYA----- Ack3_Spur ------------------------------------------------------VXCAPE TNK1_Hsap SLRHGAFSSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLE-D-RARLPRPPLCSRA Ack_Dmel SLRFRQFSHASDTWMFGVTLWEMFSFGEDPWVGLNGSQILRKIDRE-GERLHQPDACPPD PR2_Dmel CINYLRFTNASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSE ACK_Mmus SLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKE-GERLPRPEDCPQD kin-25_Cele ALRHRKFSHASDVWSYGVTIWEVFTFGEEPWVGCRAIDVLKNID-A-GERLEKPKYCSER ark-1_Cele CINFLKFTSKSDVWAYGVTIWEMFSYGEMPWKGRSGAQILELVDRK-KELLTRPKACPED TNK1_Mmus SLRQGAFSSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLEKD-RARLPKPPLCSRA ACK_Hsap SLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKE-GERLPRPEDCPQD Ack1_Spur SLTKLTFTKASDVWSFGVTMWEMFSYGRKPFAHLSGEEVITS------------------ Ack2_Spur ------------------------------------------------------------ Ack3_Spur SLKTKQFSHASDMWMFGVTLWEMFSFGEEPWLGYNGAQILQKIGKE-GERLPRPDHCPPG TNK1_Hsap LYSLALRCWAPHPADRPSFSHLEGLLQEAGPSEA--CCVRDVTEPG--ALRMETGDPITV Ack_Dmel VYAMMLQCWDKTPAERPTFAALKEYLASMSPPVM--RASRSHHESK--GLQIEPGDTIAI PR2_Dmel YYTLMMKCWQDDAAKRPRFGEIYDQLPDMKPEQL--KAVVNCTEPKKDHLLYRQGDIISV ACK_Mmus IYNVMVQCWAHKPEDRPTFVALRDFLLEAQPTDM--RALQDFEEPD--KLHIQMNDVITV kin-25_Cele IYQIMKNCWKFNPAERCKFGAIREDLVAAMFLDAVARETYNSIQPG--ALQLTKGDEVVV ark-1_Cele IYDMLKETWTHQVQDRPTFSDIVAKFPERRAQSV--RAVVDCKDSAADHLHFKKDDLIVV TNK1_Mmus LYSLALRCWAPHPADRPSFSNLEGLLQEAWLSEG--RCVREVTEPG--ALRMEPGDPITI ACK_Hsap IYNVMVQCWAHKPEDRPTFVALRDFLLEAQPTDM--RALQDFEEPD--KLHIQMNDVITV Ack1_Spur ------------------------------------------------------------ Ack2_Spur ------------------------------------------------------------ Ack3_Spur IYSLMEICWQANPEDRPMFSSVKDQLDKMKPLEM--RVTKDFDEPD--KLECEEGQIITI TNK1_Hsap IEGSSSFHSPDSTIWKGQNGRTFKVGSFP-ASAVTLAD-AGG------------------ Ack_Dmel IDGRH-----ELKLIKGQNQRTFDIGIFP-RNLLEQRKVGAA------------------ PR2_Dmel LDRNT-----GTPFWKGV-LSTGKTGYFNPSNTVAFLEGLPS---STRDS---------- ACK_Mmus IEGRA-----ENYWWRGQNTRTLCVGPFP-RNVVTSVAGLSA------------------ kin-25_Cele VENTG-------QDWFGQNKKNQKFGTFP-RSVVFAQT-NNAVAAATAVTPQKVPTAPTI ark-1_Cele ISRSPAQ-YPDGYYWFGS-LRNGKLGLFRPTDTVAHLGSEPP---CSNGT--------IE TNK1_Mmus IEGSL-----DTATWKGQNGRTLKVGNFP-ASAVTLAD-LGG------------------ ACK_Hsap IEGRA-----ENYWWRGQNTRTLCVGPFP-RNVVTSVAGLSA------------------ Ack1_Spur ------------------------------------------------------------ Ack2_Spur ------------------------------------------------------------ Ack3_Spur IDGKP-----EENWWLGQNIHTHKIGRIP-RKLLAPMSGITG------------------ TNK1_Hsap ---------------------------LPATRPVHRGTPA--RGDQ----HPGSID---- Ack_Dmel ---------------------------GDV---VMRSSVGNGSSSSPFGFCWGGAAAMAN PR2_Dmel ---FS--------RVSDHRISKRKLRTEMISKPQ-NDFKHTGHVGID-GATFGDIAFLG- ACK_Mmus ---------------------------QDISQPLQNSFIHTGHGDSDPRHCWGFPDRIDE kin-25_Cele RIPPSHPPPAPLKPLNNNTKTSLNDRTSKISMPVAGSFIHTGHGDPLGGQSWGNPATIAD ark-1_Cele NG-FSEKEKGGKKNKKAEKESERERKKLLISEPV-GDVRHTCHVGID-GTAFGLLQLDK- TNK1_Mmus ---------------------------SPVTHPAHRGSPA--HGEK----CRGGTD---- ACK_Hsap ---------------------------QDISQPLQNSFIHTGHGDSDPRHCWGFPDRIDE Ack1_Spur ------------------------------------------------------------ Ack2_Spur ------------------------------------------------------------ Ack3_Spur ---------------------------EDISKPIKYSFIHTGHGGVD-GNTWGHPDKIDE TNK1_Hsap ------------------------------------------------------------ Ack_Dmel GDDRQRKCASMTNQPHAKERKSTSSKQFAYNKLVNDSATGLQRRNAVKHKGVV--VGPQR PR2_Dmel ---------SSQNYNHVPKQI-------------------VTPYKPSEDIEQTPLLLPPT ACK_Mmus LYL-----GNPMDPPDLLSVE-------------------LSTSRPTQHLGRVKREPPPR kin-25_Cele MYL-----KNPVNGAPLSSMSSGA---------------EIIASKELLTNGGRST-HQPA ark-1_Cele ---------KAM-------CP--------------------TSSSPS--TSRG-SQASPA TNK1_Mmus ------------------------------------------------------------ ACK_Hsap LYL-----GNPMDPPDLLSVE-------------------LSTSRPPQHLGGVKREPPPR Ack1_Spur ------------------------------------------------------------ Ack2_Spur ------------------------------------------------------------ Ack3_Spur LYD-----DVPNEAGDASTVT-------------------AEVSK--------KSQ-PPA TNK1_Hsap ------------------------------------------------------------ Ack_Dmel PP---------PPQ-FQQEG---------------------------------------- PR2_Dmel PT---------SPDSLQTASGYFPEGANSGGAMGTSMNPTFIPSAEHTPKLIATNGQSSF ACK_Mmus PP---------QPAIFTQKT---------------------------------------- kin-25_Cele AP---------SPAVMSKIRG--------------------------------------- ark-1_Cele PS---------HTSSSTTSSVHL------------------------------------- TNK1_Mmus ------------------------------------------------------------ ACK_Hsap PP---------QPAFFTQKP---------------------------------------- Ack1_Spur ------------------------------------------------------------ Ack2_Spur ------------------------------------------------------------ Ack3_Spur RSYYGNQQIIADAAALEDTP---------------------------------------- TNK1_Hsap ------------------------------------------------------------ Ack_Dmel ---------------------------------------------------ILIDISPD- PR2_Dmel DFASGSTNPFFPNRGDDELEFGLHNYGADGKSVHSETGWRPTSRSIVDDPHEYHEISDDE ACK_Mmus ---------------------------------------------------TYDPVSED- kin-25_Cele ---------------------------------------------------LSLDL-PE- ark-1_Cele ----------------------------------------------------RETVARNG TNK1_Mmus ------------------------------------------------------------ ACK_Hsap ---------------------------------------------------TYDPVSED- Ack1_Spur ------------------------------------------------------------ Ack2_Spur ------------------------------------------------------------ Ack3_Spur ---------------------------------------------------TYDDVPNE- TNK1_Hsap ------------------------------------------------------------ Ack_Dmel -----------MRPIA---------------------EAG-------------------- PR2_Dmel IA--AD--KLDFGPSLLDEINSMFGSISAATGSHPKSPGFD-HVNNKNEITEMS------ ACK_Mmus -----------PDPLS---------------------SDFK-RLGLRKPALPRG------ kin-25_Cele -----------YDDFD---------------------RAFDDGFSPSKIELPREFCGNDS ark-1_Cele VPIKETMSLRDVGPLSRD--------------ALNLRDTVS-PPVARAPSQPPS------ TNK1_Mmus ------------------------------------------------------------ ACK_Hsap -----------QDPLS---------------------SDFK-RLGLRKPGLPRG------ Ack1_Spur ------------------------------------------------------------ Ack2_Spur ------------------------------------------------------------ Ack3_Spur ------------SNLS---------------------SD-----TLSKNATAKG------ TNK1_Hsap -----------------------------------------G------------------ Ack_Dmel -------------------------TG---------GAKGAGDSSSLQADSSFCILDAPI PR2_Dmel --------AKLGQKSGD-----TNGNKHGHGLLPTLSKKKSSGTVKPISVKDEKILNHAI ACK_Mmus --------LWLAKPSAR-----VPGTK---------ADRSSGGEVTLIDFGEEPVVPTPR kin-25_Cele VISGGSNSIGLANTYVM-----EPPKQ---------AFDIRGNRV-LPPTNKAPVLIPTN ark-1_Cele --------YSQPRPPPRSVSSVSSGNQHSVQ---------VHDQFSSLDRSRGSLTPTAP TNK1_Mmus -----------------------------------------G------------------ ACK_Hsap --------LWLAKPSAR-----VPGTK---------ASRGSGAEVTLIDFGEEPVVPALR Ack1_Spur ------------------------------------------------------------ Ack2_Spur ------------------------------------------------------------ Ack3_Spur --------DWV------------------------------------------------- TNK1_Hsap ----------------------------DRKKAN-------------------------- Ack_Dmel ---------------------------------------------------------DVP PR2_Dmel EIANEISA---------------------------------------------------- ACK_Mmus ---------------------------------------------------------PCA kin-25_Cele P-APSVISSTASAGITLSTNSSQMFTSQDRHSNMPANLFPELQHRLNQGSSTGNGVRPRP ark-1_Cele PLTASAANSLKDPLTGISLSIP-------------------------------------- TNK1_Mmus ----------------------------DREKAT-------------------------- ACK_Hsap ---------------------------------------------------------PCA Ack1_Spur ------------------------------------------------------------ Ack2_Spur ------------------------------------------------------------ Ack3_Spur ------------------------------------------------------------ TNK1_Hsap ------------LWD--------------------------------------------- Ack_Dmel TYA-----GSSGSGDL---------------------NVSPTYYNE-------------- PR2_Dmel -------RSMIDLVSDQTP----VI-------------HSPKRKFSFRFPHLSNNGSGDK ACK_Mmus PSLAQLAMDACSLLDKT-P------------------PQSPTRALP--RP---------- kin-25_Cele ASSIGIQNNDLSMLNPQ-Q------------------PANIPCLVP--TP---------- ark-1_Cele ------SNNLISYMDDQEDDHRWTRSPGAISQSTTLTALSSSRKDPIPAP---------- TNK1_Mmus ------------LQD--------------------------------------------- ACK_Hsap PSLAQLAMDACSLLDET-P------------------PQSPTRALP--RP---------- Ack1_Spur ------------------------------------------------------------ Ack2_Spur ------------------------------------------------------------ Ack3_Spur -----------NFYDDV-P------------------TESDLAKLE--SK---------- TNK1_Hsap --------APPARGQR------------------------RNM----------------- Ack_Dmel -----------QPQFDFDPAKMTASPGRLQPPPYQMPPTYSNTMEFVQKRDLHQQQLATP PR2_Dmel SGGLGTSGSAHTPT-HGNAS------------PFPKKKNFTEE----------------- ACK_Mmus --------LHPTPVVDWDAR------------PLPPPPAYDDV----------------- kin-25_Cele --------APPAPAHFS------------------QPVSSQRV----------------- ark-1_Cele --------RGPVAAVYARGK------------DIPTPASKSDI----------------- TNK1_Mmus --------LPPARSHR------------------------TKM----------------- ACK_Hsap --------LHPTPVVDWDAR------------PLPPPPAYDDV----------------- Ack1_Spur ------------------------------------------------------------ Ack2_Spur ------------------------------------------------------------ Ack3_Spur --------AGPLPLRTYDEV------------PVDEPRVFPQD----------------- TNK1_Hsap PLE--RMKGISRSLESVL------------------------------------------ Ack_Dmel VRE--RDPFDTTNVETTVAL-----------------------YSNFNQS---------L PR2_Dmel L--QSIPD-----IQSLIGKEGLEAYNSLIERKALLDIGPSPAATLLRHLDTDEFDLQSL ACK_Mmus AQD--EDDFEVCSINSTLVG-------------AGLPAGPSQGETNYAFV---------P kin-25_Cele AQQ--QQNTLQKALNDEL------------------------------------------ ark-1_Cele ALCEKIED-----LNRDLTNYSIGTICDY---------------------SEDRPLLDSM TNK1_Mmus PLQ--RMRGISKSLESVL------------------------------------------ ACK_Hsap AQD--EDDFEICSINSTLVG-------------AGVPAGPSQGQTNYAFV---------P Ack1_Spur ------------------------------------------------------------ Ack2_Spur ------------------------------------------------------------ Ack3_Spur M--QDL------------------------------------------------------ TNK1_Hsap -----------SLGPRPTGGGSSPPEIRQA-RAV-------------------------- Ack_Dmel EAASPPAPIYNSPSVR---------KSLF----GGSKSNKENIPALESAAMQL----NLS PR2_Dmel HQSQRP------MTLPTRGATQRVRKAELAA-G-LSRHNDENSNSLEACE-------SPS ACK_Mmus EQAQMPPALEDNLFLPPQGGGKPPSSVQTAE--IFQALQQECMRQLQVPTGQL----TPS kin-25_Cele ---------KGNLNKRPTGTTAPPSNGFNAPRADVAPVQQRPISSASIP--AL----QPQ ark-1_Cele NRTI-----------SSSTTHQPPPQSSEAR-I-RFMTEQEVRKINEKSA--REHRKTED TNK1_Mmus -----------SLGPRPTGGGSSPPELRRT-RAM-------------------------- ACK_Hsap EQARPPPPLEDNLFLPPQGGGKPPSSAQTAE--IFQALQQECMRQLQAPAGSP----APS Ack1_Spur ------------------------------------------------------------ Ack2_Spur ------------------------------------------------------------ Ack3_Spur --------------------QQPPSSSHKVV--RLQVLHQECQRPGWEPKSGT----SSS TNK1_Hsap -----------------------PQ---------GP------------------------ Ack_Dmel NLTLERH-----------DATCIQPVEPVP-APPG--D---GVLLDKSFIAELE---KDM PR2_Dmel YMTHGSYKFPEAQPTEQLPEPESPNP--IP-LPPR--EGKKQVKTSTKRHVRKYPL---I ACK_Mmus P-TPGGD-----------DKPQVPPR--VP-IPPR--PTRPRVELSPAPSGEEE---TSR kin-25_Cele P-IQH-I-----------QKPIQPQQ--VR-IPPSTAPVQKPVQVSAPTHSNVAPTTSSQ ark-1_Cele LLR-EE-RQKEQKP-GEIEEPQQPAE--SL-YSTR--TPQQEGWSSAAQEAYKLLV---E TNK1_Mmus -----------------------PQR--LPDLPPRP------------------------ ACK_Hsap P-SPGGD-----------DKPQVPPR--VP-IPPR--PTRPHVQLSPAPPGEEE---TSQ Ack1_Spur ------------------------------------------------------------ Ack2_Spur ------------------------------------------------------------ Ack3_Spur P-SPTGE-----------D------------VPPA--V---------------------- TNK1_Hsap -----------------------PGLPPRPPLSSSS------------------------ Ack_Dmel YSNGQNRAQEEYQRNSTQMYASKDMV-YKQNLTPLKNGAAPGSVHSNHSSPS-------- PR2_Dmel IPAN----------------GLQ--RT-LSKLADFGDEAAKSPEISTSSQPQPGRAIENL ACK_Mmus WPGP----------------ASPPRVPPREPLSPQGS-RTPSPLVPPGSSPLPHRLSSSP kin-25_Cele ASAD----------------AR-NPLPPKT--SPPVS-NTPITVAPVHAAPTTSAPSTSV ark-1_Cele CGTN----------------LKQASVS-PPPMSPTSS-RL-STLDRSSISPAPPRPVTPP TNK1_Mmus -----------------------PDLPPRPPIICNS------------------------ ACK_Hsap WPGP----------------ASPPRVPPREPLSPQGS-RTPSPLVPPGSSPLPPRLSSSP Ack1_Spur ------------------------------------------------------------ Ack2_Spur ------------------------------------------------------------ Ack3_Spur --------------------------------GPHQS-N--------------------- TNK1_Hsap ------------------------------------------------------------ Ack_Dmel ---------ST-ASPKQNNVEAAAAAA----ATT------------------QSVVNRIW PR2_Dmel DKLTPADAAGLTDTASLQFESIMEADT----SKE------------------GILQSPDV ACK_Mmus GKTMPTTQSFA-SDPKYATPQVIQAPG----PRA------------------GPCILPIV kin-25_Cele VTRRPTSTTAQMSDEERRSRIAMDISSALPAPSALLYGSNSTSSLPSAAVSTASSVPSTA ark-1_Cele LSVRNETISMRKSQQEEMEHVTVEENS----PKR------------------VHIIE--- TNK1_Mmus ------------------------------------------------------------ ACK_Hsap GKTMPTTQSFA-SDPKYATPQVIQAPG----PRA------------------GPCILPIV Ack1_Spur ------------------------------------------------------------ Ack2_Spur ------------------------------------------------------------ Ack3_Spur -------------------------QQ----PPG------------------GSMILPIM TNK1_Hsap ------PQ---PSQPSRERLPWPKRKPP-------------------------------- Ack_Dmel YEQV---A---STQSEYYA---QPPTEQAEEQIYQ------------------------- PR2_Dmel TDGF---YNFSIQKEHYNK---GKD--AE-FEATQISGLYVNDDELRNLDIESSRRTATP ACK_Mmus RDGR---K---VSSTHYYL---LPERPPYL-ERYQ------------------------- kin-25_Cele RDNPVETR---PSQPHVTM---PPKKSSEP-ILSS------------------------- ark-1_Cele -----------------------------------------------------TKLIDGP TNK1_Mmus ------SQ---PTQPHKAR---PKRESS-------------------------------- ACK_Hsap RDGK---K---VSSTHYYL---LPERPSYL-ERYQ------------------------- Ack1_Spur ------------------------------------------------------------ Ack2_Spur ------------------------------------------------------------ Ack3_Spur KDGV---Q---VSHTHYYL---LP------------------------------------ TNK1_Hsap ------------------------------------------------------------ Ack_Dmel ----NHRHQQQQQQELNHSFV----AISNRVVAPKN--NAYSSTASLYDAVAASTAGSTY PR2_Dmel CSSCSALESEHSQPDALPSTE-SVS--EVSRFSSVDNELAG----------NA------L ACK_Mmus ----RFLREAQSPEEPAAL------PVPPLLPPPST--PAP----------AA------P kin-25_Cele ----EVLQPTRLPSATTSQAKPVTQPIRHPSPPVAT--VIP----------TA------V ark-1_Cele ARGMSPIQDRHIPAFTTPMSNGSFR--KAPAPTPVS--PAP----------AG------S TNK1_Mmus ------------------------------------------------------------ ACK_Hsap ----RFLREAQSPEEPTPL------PVPLLLPPPST--PAP----------AA------P Ack1_Spur ------------------------------------------------------------ Ack2_Spur ------------------------------------------------------------ Ack3_Spur ------------------------------------------------------------ TNK1_Hsap ------------------------------------------------------------ Ack_Dmel YGQVPNGSGAVLYDEVTQDDYLRPTR-----------------------------PA--- PR2_Dmel FKKVRASVNMAMNRKSVAETSLTSNQ-----------------------------PG--- ACK_Mmus TATVRPMPQAAPDPK--ANFSTNNSN-----------------------------PG--- kin-25_Cele VD-KKPVSQNQGSNV--PLFNITNSSNGYPQLNGYPNYGNGFQAYGYGMNYHQGYPGYQG ark-1_Cele T---------------------DQKP-----------------------------PP--- TNK1_Mmus ------------------------------------------------------------ ACK_Hsap TATVRPMPQAALDPK--ANFSTNNSN-----------------------------PG--- Ack1_Spur ------------------------------------------------------------ Ack2_Spur ------------------------------------------------------------ Ack3_Spur ------------------------------------------------------------ TNK1_Hsap --------------HNHPMGMP-------------------------------------- Ack_Dmel -------------------PLAPPPLSAQQI----QRRMEKM----RLQQQQQ--L---- PR2_Dmel -------------------GASAKPQTEAEYFAATAA---------RLADSNSVSCEDLL ACK_Mmus -------------------ARPPSLRATARL-----------------PQR-G--C---- kin-25_Cele YNSYGNGMGQLALTHNAVTSLPPLVPSENRF-SGTAQPLGESDIMEFLGTQQR--Q---- ark-1_Cele -------------------CRPPKT----------------------------------- TNK1_Mmus --------------HNHRTGAP-------------------------------------- ACK_Hsap -------------------ARPPPPRATARL-----------------PQR-G--C---- Ack1_Spur ------------------------------------------------------------ Ack2_Spur ------------------------------------------------------------ Ack3_Spur ------------------------------------------------------------ TNK1_Hsap ---------GARKAAALSGGLLSDPELQRK--------------------IMEV-ELSVH Ack_Dmel DGAHQ-LYA--------PVP-SDYGREQEK--------------------LQQLMQELGS PR2_Dmel EF-----S-----DKKP-KG-CERGVDSDEVRIMVKVLGKDVSSLCTKNQISYN-QIFIS ACK_Mmus --------P--------GDG-QEAARPADK--------------------VQML-QAMVH kin-25_Cele AGSSSRAVPPASASTSAASG-ITDLSMADK--------------------MEVL-YREAD ark-1_Cele ------------------------------------------------------------ TNK1_Mmus ---------GASKATVPSGGPLSDPEWQRK--------------------VVEV-ELSVH ACK_Hsap --------P--------GDG-PEAGRPADK--------------------IQML-QAMVH Ack1_Spur ------------------------------------------------------------ Ack2_Spur ------------------------------------------------------------ Ack3_Spur ---------E------------TPNSAADK--------------------VKQV-QKEVH TNK1_Hsap GVTHQECQTALGATGGDVVSAIRNLKVDQLFHLSSR-SRAD-----CWRILEHYQWDLSA Ack_Dmel SAVEQDVRNALRAASGDVGLATRHYKIDQLARLGVA-GRPQ-----CEQALQQTNWSLEV PR2_Dmel QSTPNRCLGALEFINWDVHKSIKLIKLQNLVSEANL-SLEA-----SFEALQQHEWDLHT ACK_Mmus GVTTEECQAALQSHSWSVQRAAQYLKVEQLFGLGLR-PRVE-----CHKVLEMFDWNLEQ kin-25_Cele FTHKGNCDTMVSQCNGNTEQALKLLKQQHLVDMELAMSTET-----ARQALEARQYDLPA ark-1_Cele -------------RQFPLVIDERNLAYDNLNGFGAG-ARVAPPVPPKPKVRTIFSFADDQ TNK1_Mmus GVTYQECQVALRTTGGDVASAIRNLKVDQLFHLSNR-SRAD-----CRRILEHHQWDLSA ACK_Hsap GVTTEECQAALQCHGWSVQRAAQYLKVEQLFGLGLR-PRGE-----CHKVLEMFDWNLEQ Ack1_Spur ------------------------------------------------------------ Ack2_Spur ------------------------------------------------------------ Ack3_Spur GVTSDECRNALIGVQWDVTKAVRDLKTEQLFQLGSA-SKEH-----CENLLKSLEWNLEL TNK1_Hsap ASRYVLA-------RP Ack_Dmel AAELLLN-------AG PR2_Dmel TAHKLNG------LKL ACK_Mmus AGCHLLGSCGPAHHKR kin-25_Cele AANMLL---------G ark-1_Cele --KKQKE------VAN TNK1_Mmus ASRYILA-------RS ACK_Hsap AGCHLLGSWGPAHHKR Ack1_Spur -----SM------KCS Ack2_Spur ---------------W Ack3_Spur ASSIL----------L