CLUSTAL W (1.83) multiple sequence alignment TYRO3_Hsap MALRR-SMGRPGLPPLPLPPPPRLGLLL-AA-LAS-LLLPESAA---------------- MER_Hsap MG-------PAPLP-------LLLGLFL-PALWRRAITEAREEAKPYPLFPGPFPGSLQT MER_Mmus MV-------LAPLL---------LGLLLLPALWSGGTAEKWEETELDQLFSGPLPGRLPV AXL_Mmus M-------GRVPLA---------WWLAL-CC-WGC-AAHKDTQTE--------------- AXL_Hsap MAWRCPRMGRVPLA---------WCLAL-CG-WAC-MAPRGTQA---------------- TYRO3_Mmus MALRR-SMGWPGLRP----------LLL-AG-LAS-LLLPGSAA---------------- * * * * : TYRO3_Hsap -------------AGLKLM---------------------------------GAPVKLTV MER_Hsap DHTPLLSLPHASGYQPALMFSPTQPGRPHTGNVAIPQVTSVESKPLPPLAFKHTVGHIIL MER_Mmus NHRPF-SAPHSSRDQ----LPPPQTGRSHPAHTAAPQVTSTASKLLPPVAFNHTIGHIVL AXL_Mmus -------------AGSPFV---------------------------------GNPGNITG AXL_Hsap -------------EESPFV---------------------------------GNPGNITG TYRO3_Mmus -------------AGLKLM---------------------------------GAPVKMTV :: TYRO3_Hsap SQGQPVKLNCSVEGM----EEPDIQWVKDGAVVQNLD--QLYIPVSE---Q--HWIGFLS MER_Hsap SEHKGVKFNCSISVPNIY-QDTTISWWKDGKELLGAHHAITQFYPDD---EVTAIIASFS MER_Mmus SEHKNVKFNCSINIPNTYQETAGISWWKDGKELLGAHHSITQFYPDE---EGVSIIALFS AXL_Mmus ARGLTGTLRCELQVQ---GEPPEVVWLRDGQILELADNTQTQVPLGEDWQDEWKVVSQLR AXL_Hsap ARGLTGTLRCQLQVQ---GEPPEVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQLR TYRO3_Mmus SQGQPVKLNCSVEGM----EDPDIHWMKDGTVVQNAS--QVSISISE---H--SWIGLLS :. .:.*.:. : . : * :** : . .: . :. : TYRO3_Hsap LKSVERSDAGRYWCQVEDGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAV MER_Hsap ITSVQRSDNGSYICKMKINNEEIVSDPIYIEVQGLPHFTKQPESMNVTRNTAFNLTCQAV MER_Mmus IASVQRSDNGSYFCKMKVNNREIVSDPIYVEVQGLPYFIKQPESVNVTRNTAFNLTCQAV AXL_Mmus ISALQLSDAGEYQCMVHLEGRTFVSQPGFVGLEGLPYFLEEPEDKAVPANTPFNLSCQAQ AXL_Hsap ITSLQLSDTGQYQCLVFLGHQTFVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSCQAQ TYRO3_Mmus LKSVERSDAGLYWCQVKDGEETKISQSVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAV : ::: ** * * * : . :*:. :: ::*:*.* :*:. *. *:.*:*:*:* TYRO3_Hsap GPPEPVTIVWWRGTTKIG-GPAPSP-SVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHL MER_Hsap GPPEPVNIFWVQNSSRVNEQPEKSP-SVLTVPGLTEMAVFSCEAHNDKGLTVSKGVQINI MER_Mmus GPPEPVNIFWVQNSSRVNEKPERSP-SVLTVPGLTETAVFSCEAHNDKGLTVSKGVHINI AXL_Mmus GPPEPVTLLWLQDAVPLAPVTGHSSQHSLQTPGLNKTSSFSCEAHNAKGVTTSRTATI-- AXL_Hsap GPPEPVDLLWLQDAVPLATAPGHGPQRSLHVPGLNKTSSFSCEAHNAKGVTTSRTATI-- TYRO3_Mmus GPPEPVTIYWWRGLTKVG-GPAPSP-SVLNVTGVTQRTEFSCEARNIKGLATSRPAIVRL ****** : * :. : . .. * ..*:.: : *****:* **:: *: . : TYRO3_Hsap QALPAAPFNITVTKLSSSNASVAWMPGADGRALLQSCTVQVTQAP-----------GGWE MER_Hsap KAIPSPPTEVSIRNSTAHSILISWVPGFDGYSPFRNCSIQVKEADPL---------SNGS MER_Mmus KVIPSPPTEVHILNSTAHSILVSWVPGFDGYSPLQNCSIQVKEADRL---------SNGS AXL_Mmus TVLPQRPHHLHVVSRQPTELEVAWTPGLSGIYPLTHCNLQAVLSDDGVGIWLGKSDPPED AXL_Hsap TVLPQQPRNLHLVSRQPTELEVAWTPGLSGIYPLTHCTLQAVLSNDGMGIQAGEPDPPEE TYRO3_Mmus QAPPAAPFNTTVTTISSYNASVAWVPGADGLALLHSCTVQVAHAP-----------GEWE . * * . : . . . ::* ** .* : *.:*. : . TYRO3_Hsap VLAVVVPVPPFTCLLRDLVPATNYSLRVRCANALGPSPYADWVPFQTKGLAPASAPQNLH MER_Hsap VMIFNTSALPHLYQIKQLQALANYSIGVSCMNEIGWSAVSPWILASTTEGAPSVAPLNVT MER_Mmus VMVFNTSASPHLYEIQQLQALANYSIAVSCRNEIGWSAVSPWILASTTEGAPSVAPLNIT AXL_Mmus PLTLQVSVPPHQLRLEKLLPHTPYHIRISCSSSQGPSPWTHWLPVETTEGVPLGPPENVS AXL_Hsap PLTSQASVPPHQLRLGSLHPHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENIS TYRO3_Mmus ALAVVVPVPPFTCLLRNLAPATNYSLRVRCANALGPSPYGDWVPFQTKGLAPARAPQNFH : ... *. : .* . : * : : * . * *. *: .* .* .* *. TYRO3_Hsap AIRTDSGLI--LEWEEVIPEA-PLEGPLGPYKLSWVQDN--------GTQDELTVE---- MER_Hsap VFLNESSDNVDIRWMK--PPTKQQDGELVGYRISHVWQS-------AGISKELLEEVGQN MER_Mmus VFLNESNNILDIRWTK--PPIKRQDGELVGYRISHVWES-------AGTYKELSEEVSQN AXL_Mmus AMRNGSQVL--VRWQE--PRV-PLQGTLLGYRLAYRGQDTPEVLMDIGLTREVTLE---- AXL_Hsap ATRNGSQAF--VHWQE--PRA-PLQGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLE---- TYRO3_Mmus AIRTDSGLI--LEWEEVIPED-PGEGPLGPYKLSWVQEN--------GTQDELMVE---- . . * :.* : * :* * *::: :. * *: * TYRO3_Hsap GTRANLTGWDPQKDLIVRVCVSNAVGCGPWSQPLVVSS--H---DRAGQQGPPHS----- MER_Hsap GSRARISVQVHNATCTVRIAAVTRGGVGPFSDPVKIFIPAHGWVDYAPSSTPAPG----- MER_Mmus GSWAQIPVQIHNATCTVRIAAITKGGIGPFSEPVNIIIPEHSKVDYAPSSTPAPG----- AXL_Mmus -----LRGDRPVANLTVSVTAYTSAGDGPWSLPVPLEP--W----RPGQGQPLHHLVSEP AXL_Hsap -----LQGDGSVSNLTVCVAAYTAAGDGPWSLPVPLEA--W----RPGQAQPVHQLVKEP TYRO3_Mmus GTRANLTDWDPQKDLILRVCASNAIGDGPWSQPLVVSS--H---DHAGRQGPPHS----- : : : . . * **:* *: : . * TYRO3_Hsap -----RTSWVPVVLGVLTALVTAA-ALALI-LLRKRRKETRFGQAFDSVMARGEPAVHFR MER_Hsap -----NADPVLIIFGCFCGFILIGLILYISLAIRKRVQETKFGNAFTE--EDSELVVNYI MER_Mmus -----NTDSMFIILGCFCGFILIGLILCISLALRRRVQETKFGGAFSE--EDSQLVVNYR AXL_Mmus PPRAFSWPWWYVLLGALVAAACVL-ILALF-LVHRRKKETRYGEVFEPTVERGELVVRYR AXL_Hsap STPAFSWPWWYVLLGAVVAAACVL-ILALF-LVHRRKKETRYGEVFEPTVERGELVVRYR TYRO3_Mmus -----RTSWVPVVLGVLTALITAA-ALALI-LLRKRRKETRFGQAFDSVMARGEPAVHFR :::* . . * : :::* :**::* .* .: .*.: TYRO3_Hsap AARSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLK MER_Hsap AKKSFCRR---AIELTLHSLGVSEELQNKLEDVVIDRNLLILGKILGEGEFGSVMEGNLK MER_Mmus AKKSFCRR---AIELTLQSLGVSEELQNKLEDVVIDRNLLVLGKVLGEGEFGSVMEGNLK AXL_Mmus VRKSYSRR---TTEATLNSLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLN AXL_Hsap VRKSYSRR---TTEATLNSLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLN TYRO3_Mmus AARSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLK . :*: *. * **.***:*:**::**.**:: .: . **: **:****:* *.:*: TYRO3_Hsap QEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPI MER_Hsap QEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQ-GIPK MER_Mmus QEDGTSQKVAVKTMKLDNFSQREIEEFLSEAACMKDFNHPNVIRLLGVCIELSSQ-GIPK AXL_Mmus QDD-SILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSDREGFPE AXL_Hsap QDD-SILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPA TYRO3_Mmus QEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPI *:* : ***** :* : ::*:** **.***:*.**:* :*:**.:. : :* TYRO3_Hsap PMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAA MER_Hsap PMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAA MER_Mmus PMVILPFMKYGDLHTFLLYSRLNTGPKYIHLQTLLKFMMDIAQGMEYLSNRNFLHRDLAA AXL_Mmus PVVILPFMKHGDLHSFLLYSRLGDQPVFLPTQMLVKFMADIASGMEYLSTKRFIHRDLAA AXL_Hsap PVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAA TYRO3_Mmus PMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLVRFMVDIACGMEYLSSRNFIHRDLAA *:*******:****::** **: * : * *::** *** ******.:.*:****** TYRO3_Hsap RNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAF MER_Hsap RNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAF MER_Mmus RNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAF AXL_Mmus RNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSF AXL_Hsap RNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSF TYRO3_Mmus RNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVHSDVWAF ***** ::*:*********:***.******* :*:****:*:*****.:** :****:* TYRO3_Hsap GVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPS MER_Hsap GVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPT MER_Mmus GVTMWEITTRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYDIMYSCWSADPLDRPT AXL_Mmus GVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPVDCLDGLYALMSRCWELNPRDRPS AXL_Hsap GVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPS TYRO3_Mmus GVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEEVYDLMYQCWSADPKQRPS ******* *** ***.*::* *:*:** *:***** :*:: :* :* ** :* :**: TYRO3_Hsap FTCLRMELENILGQLSVLSASQDPLYINIERAEE--PT----AGGSLELPGRDQPYSGAG MER_Hsap FSVLRLQLEKLLESLPDVRNQADVIYVNTQLLESSEGLAQGSTLAPLDLNIDPDS--IIA MER_Mmus FSVLRLQLEKLSESLPDAQDKESIIYINTQLLESCEGIANGPSLTGLDMNIDPDS--IIA AXL_Mmus FAELREDLENTLKALPPAQEPDEILYVNMDEGGS--HLEPRGAAGGADPPTQPDPKDS-- AXL_Hsap FTELREDLENTLKALPPAQEPDEILYVNMDEGGG--YPEPPGAAGGADPPTQPDPKDS-- TYRO3_Mmus FTCLRMELENILGHLSVLSTSQDPLYINIERAEQ--PT----ESGSPEVHCGERSSSEAG *: ** :**: *. . :*:* : : . TYRO3_Hsap DGSGMGAV----GGT----PSDCRYILTPGGL-------AEQPGQA-E-HQPESPLN--- MER_Hsap SCTPRAAISVVTAEVHDSKPHEGRYILNGGSEEWEDLTSAPSAAVTAEKNSV-LPGERLV MER_Mmus SCTPGAAVSVVTAEVHENNLREERYILNGGNEEWEDVSSTPFAAVTPEKDGV-LPEDRLT AXL_Mmus -CSCLTA-----ADV----HSAGRYVLCPST--------APGPTLSADRGCPAPPGQ--- AXL_Hsap -CSCLTA-----AEV----HPAGRYVLCPST--------TPSPAQPADRGSPAAPGQ--- TYRO3_Mmus DGSGVGAV----GGI----PSDSRYIFSPGGL-------SESPGQL-E-QQPESPLN--- : * . **:: . : . : * : TYRO3_Hsap ET-----------------QRLLLLQQGLL-PHSSC MER_Hsap RNGVSWSHSSMLPLGSSLPDELLFADDSSEGSEVLM MER_Mmus KNGVSWSHHSTLPLGSPSPDELLFVDDSLEDSEVLM AXL_Mmus E--------------------------------DGA AXL_Hsap E--------------------------------DGA TYRO3_Mmus EN-----------------QRLLLLQQGLL-PHSSC .