CLUSTAL W (1.83) multiple sequence alignment BCR_Mmus MVDSVGFAEAWRAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQ BCR_Hsap MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQ BCR_Spur MGG--------------------------------------------------------- RhoGAP1A_Dmel MSVFDDFQRLWMQRFPQSSLSDAW---EQDVRASLERHKVRINELSKELEQETLYVEYLE ABR_Hsap MWDPRAFERRWRAEFPGAEAPVPRLESVRDAERELERRRLNLERLQQVLAEEQLKASLPQ ABR_Mmus MWDPQEFERHWQAEFPGEETPVMKLESVPDMERELERCKLNLKRLQQVLAEEKFKVWYLQ * BCR_Mmus TLLAKEKKSYDRQRWGFRRAAQ---PPDGAAEPRASAPRPPPAPADGADPAPVEESEARP BCR_Hsap TLLAKEKKSYDRQRWGFRRAAQ---APDGASEPRASASRPQPAPADGADPPPAEEPEARP BCR_Spur ------------------------------------------------------------ RhoGAP1A_Dmel RLLSDVER----YRVSGGDPKALFEAASGSC---ASSNNSNC--SSTTNGATQEESNTNL ABR_Hsap AALARG---------GGGDSG-----EPGRPDPEAESPRGDPGRPDPEAESPRG------ ABR_Mmus AALAGGKMELPGGRSEGGDGGG---CSSDTGSGGASVKEQEPAGPVRAPPPRDKEGAAGR BCR_Mmus DGEGSPSKGRSASAR----------------RPAAAASADRD--DR-------------- BCR_Hsap DGEGSPGKARPGTAR----------------RPGAAASGERD--DR-------------- BCR_Spur ------------------------------------------------------------ RhoGAP1A_Dmel DKDFKSSLN-------------------LRESPSSTGAKDKDRLSLNPDNKYTTHTNAVI ABR_Hsap ---------------------------DLPAGPGAAGEA--------------------- ABR_Mmus DPD-SPGPAHPGSEVATPAEPSPYVCLDLPAWPGAMEGG--------------------- BCR_Mmus ---------GPP-----------------------------------------TSVAALR BCR_Hsap ---------GPP-----------------------------------------ASVAALR BCR_Spur ------------------------------------------------------------ RhoGAP1A_Dmel GGIGSEKVSGPLHSTQITADGKRTGELYLKREEDKCKDSNSEDTDGALQQCITELAASLK ABR_Hsap ---------G-----------------------------------------------GGR ABR_Mmus ---------G-----------------------------------------------AVR BCR_Mmus SNFEKIRKGPAQPGSADAEKPFYVNVEFHHERG-LVKVNDKEVSDRISSLGSQAMQMERK BCR_Hsap SNFERIRKGHGQPG-ADAEKPFYVNVEFHHERG-LVKVNDKEVSDRISSLGSQAMQMERK BCR_Spur ------------------------------------------------------------ RhoGAP1A_Dmel AQPDNVAGGRLEND-VDIDKPLRKSTSQYVTVIQVKEAKDKESADGTTSSSG-IGEPQQQ ABR_Hsap SW-------------ADA-----VHRQLLQPQL-RFRAREDD------------------ ABR_Mmus SL-------------TAA-----IHQQLVQPRL-LFRLREDCAPPGNDGTGSTVPG-EER BCR_Mmus KSQQSAGQGLGEAPRPHYR-GRSSESSCGLDGDYEDAELNPRFLKDNLINANG--GNR-- BCR_Hsap KSQHGAGSSVGDASRPPYR-GRSSESSCGVDGDYEDAELNPRFLKDNLIDANG--GSR-- BCR_Spur ------------------------------------------------------------ RhoGAP1A_Dmel PTPPSTFSRYSEATAPPLS-PSLTSYAAHVEAK---KKMPPRPPPKNIRRVEP--P---- ABR_Hsap -------APL---GDPQAAPGTDE-GGDGGDHDFEMVDFNEKFILSHWLVAPCRFGTRER ABR_Mmus SSETGTGRGS-EEGEPDAS-GGDD-GGDCSDHDFEMVDLNEKFVLGHLLMAPCRFGTRDE BCR_Mmus --PPWPPLEYQPYQSI--YVGGMM-----------VEGEG------------------KS BCR_Hsap --PPWPPLEYQPYQSI--YVGGMM------------EGEG------------------KG BCR_Spur ------------------------------------------------------------ RhoGAP1A_Dmel -TIPSQQLSSSPKRETYM--INTM------------PSSSSGSLCIDSLGNSLERNIKPS ABR_Hsap A--------RSPRRWMHLIPGGRR-PQRGTRDLEQREAEAKG--------------RPGS ABR_Mmus AEKPARP--CSPHRWMHLISGGWRHHRRRSRDLEQLEAEDE------------------S BCR_Mmus PLLRSQSTSEQEKRLTWPRRSYSPRSFEDSGGGYTPDCSSNENLTSS--EEDFSSGQSSR BCR_Hsap PLLRSQSTSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSS--EEDFSSGQSSR BCR_Spur ------------------------------------------------------------ RhoGAP1A_Dmel DILRQKSSDNLDSKYSAKRKT-------------TPELSKFVNVNN--PELMEELGR-KM ABR_Hsap PL-AAEETPGREHLPPWRRRRFLRVPERDSPGHSSPERDSDGSRHSSDREDDFS------ ABR_Mmus PR-----RGAREHLAQWGRKRFLRVPDRDSPSHSSPERGSDCSHNSSDHEDGFS------ BCR_Mmus VSPSPTTYRMFRDKSRSPSQNSQQSFDSSSPPTPQCQKRHRQCQVVVSEATIVGVRKTGQ BCR_Hsap VSPSPTTYRMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSEATIVGVRKTGQ BCR_Spur ------------------------------------------------------------ RhoGAP1A_Dmel VSKADSL-EQTRRNDSSPSGCGSLGRTSSTPGRSLTPGR-----TGVGASPTGSLSKTGK ABR_Hsap ------------------------------------------------------------ ABR_Mmus ------------------------------------------------------------ BCR_Mmus IWPSDG--------DSTFQGEADSSFGTPPGYGCAADQAEEQRRH--------------- BCR_Hsap IWPNDG--------EGAFHGDADGSFGTPPGYGCAADRAEEQRRH--------------- BCR_Spur ------------------------------------------------------------ RhoGAP1A_Dmel LAMADSSSTSSLERRSCLQ-AVDADIGTESRESGANQRSVGSKESLTSQGISEVIKSYES ABR_Hsap ---------------------ADFSYGTDEYDGEGNEEQKGPPEG--------------- ABR_Mmus ---------------------ADFSYGAEDYDAEGHEEQKGPPEG--------------- BCR_Mmus ------------------------QDGLPYIDDSP------------------------- BCR_Hsap ------------------------QDGLPYIDDSP------------------------- BCR_Spur ------------------------------------------------------------ RhoGAP1A_Dmel VSSLSSESAKAVASQQSAAAGGALAECEPYYDSVPLDNGDGEYVFIKPGRTGSSSSRDDL ABR_Hsap ------------------------SETMPYIDESP------------------------- ABR_Mmus ------------------------SETMPYIDESP------------------------- BCR_Mmus ---------------SSSPHLSSKGRGSLAS---GALDPTKVSEL--------------- BCR_Hsap ---------------SSSPHLSSKGRGSRDALVSGALESTKASEL--------------- BCR_Spur ------------------------------------------------------------ RhoGAP1A_Dmel STPGSSILPLPNVADPESPGRTSNY-VNIDFFLQQGI-ETRSSSLDSDGEYEGPPILRTI ABR_Hsap ---------------TMSPQLSARSQGGGDGV-SPTPPEGLAPGV--------------- ABR_Mmus ---------------TMSPQLSARSQGGGDSV-SPTPPEGLAPGV--------------- BCR_Mmus --------------------------DLEKGLEMRKWVLSGILASEETYLSHLEALLLPM BCR_Hsap --------------------------DLEKGLEMRKWVLSGILASEETYLSHLEALLLPM BCR_Spur ------------------------------------------------------------ RhoGAP1A_Dmel SHDDQTTTQTTPGAIRKNLVSAILVCGNARGAKIRS-ILSSIIQSETIYVECLNKMMQYK ABR_Hsap --------------------------EAGKGLEMRKLVLSGFLASEEIYINQLEALLLPM ABR_Mmus --------------------------EAGKGLEMRKLVLSGFLASEEIYINQLEALLLPM BCR_Mmus KPLKAAATTSQPVLTSQQIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKL BCR_Hsap KPLKAAATTSQPVLTSQQIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKL BCR_Spur ------------------------------------------------------------ RhoGAP1A_Dmel KAIHATLTTSQPVIREEEENTIFFKIDELYDLHTGFLSDLKTIVSHEGGDVLIGEPFRRL ABR_Hsap KPLKATATTSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKL ABR_Mmus KPLKATATTSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKL BCR_Mmus ASQLGVYRAFVDNYGVAMETAEKCCQANAQFAEISENLRARSNKDVKDSTTKNSLETLLY BCR_Hsap ASQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDAKDPTTKNSLETLLY BCR_Spur ------------------------------------------------------------ RhoGAP1A_Dmel AEMFDLYSAFLHNYKNAIETVKKCSANNPQFKKIVSTIVLNL-----QTEQSLTLEDLLH ABR_Hsap ASQLGVYKAFVDNYKVALETAEKCSQSNNQFQKISEELKVKGPKDSKDSHTSVTMEALLY ABR_Mmus ASQLGVYKAFVDNYKVALETAEKCSQSNNQFQKISEELKVKGPKDSKDSHTSVTMEALLY BCR_Mmus KPVDRVTRSTLVLHDLLKHTPSSHPDHSLLQDALRISQNFLSSINEEITPRRQSMTVKKG BCR_Hsap KPVDRVTRSTLVLHDLLKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKG BCR_Spur -----------LKSDLLKHTPEHHEDHSILSQVLEKTRKFFKQVDEAT--R-E-IHST-K RhoGAP1A_Dmel KPVARVQINALVFNDLLRETPNAHPDHQPLRQAQKIIQMFLNQFNV--VNQRLPIESN-R ABR_Hsap KPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQDALRISQNFLSSINEDIDPRRTAVTTPKG ABR_Mmus KPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQDALRISQNFLSSINEDIDPRRTAVTTPKG : ***:.** * *: * :. . : *:...: : : BCR_Mmus EHRQLLKDSFMVELVEGARKLRHIFLFTDLLLCTKLKKQSG---GKTQQYDCKWYIPLTD BCR_Hsap EHRQLLKDSFMVELVEGARKLRHVFLFTDLLLCTKLKKQSG---GKTQQYDCKWYIPLTD BCR_Spur QKRELLRQGYLVEWTEGGRKLRRVLLWSDLIICASKKNTSGMFQRDRGQYDFQWYIPLTE RhoGAP1A_Dmel NLRRMVRNSFIVELVDGHRKLRHLFLFNDVIACAKYKAL-G---RDRIDYELKWFIPLKD ABR_Hsap ETRQLVKDGFLVEVSESSRKLRHVFLFTDVLLCAKLKKTSA---GKHQQYDCKWYIPLAD ABR_Mmus ETRQLVKDGFLVEMSESSRKLRHVFLFTDVLLCAKLKKTSA---GKHQQYDCKWYIPLAD : *.::::.::** :. ****:::*:.*:: *:. * . . :*: :*:*** : BCR_Mmus LSFQMVDELEALPNIPLVPDEELDALKIKISQIKSDIQREKRANKG----SKVMERLRKK BCR_Hsap LSFQMVDELEAVPNIPLVPDEELDALKIKISQIKNDIQREKRANKG----SKATERLKKK BCR_Spur LSLTPNDRCEAEPDVVAKSDAELRQMKKDISELQEKIKRDK-AAKQSNAIKKSIEQKRKQ RhoGAP1A_Dmel VSIY--EEADPAVELKESSPANISQVKRNLRSVRDQLAMEV-ANSG-SGAFRSGDKYRRK ABR_Hsap LVFPSPEESEASPQVHPFPDHELEDMKMKISALKSEIQKEK-ANKGQ---SRAIERLKKK ABR_Mmus LVFPSPEESEASPQVHPFPDHELEDMKTKISALKSEIQKEK-ANKGQ---SRAIERLKKK : : :. :. :: . :: :* .: ::..: : * . : :: ::: BCR_Mmus LSEQESLLLLMSPSMAFRVHSR-NGKSYTFLISSDYERAEWRESIREQQKKCFK--SFSL BCR_Hsap LSEQESLLLLMSPSMAFRVHSR-NGKSYTFLISSDYERAEWRENIREQQKKCFR--SFSL BCR_Spur AAELEVGYVLESPNLPFHLYHH-SGKTYTILMSSDYERSDWKDSILSAKRECRI--TPSI RhoGAP1A_Dmel LADLESQLVLATPNLVLRLGNKANNKTITFFLSSDFERTQWIDSILSLKQKCNLPGANTI ABR_Hsap MFENEFLLLLNSPTIPFRIHNR-NGKSYLFLLSSDYERSEWREAIQKLQKKDLQ--AFVL ABR_Mmus MFENEFLLLLNSPTIPFRIHNR-NGKSYLFLLSSDYERSEWREAIQKLQKKDLQ--AFVL : * :* :*.: ::: : ..*: :::***:**::* : * . ::: : : BCR_Mmus TSVELQMLTNSCVKLQ-TVHHIPLTINKEDDESPGLYGFLHVIVHSATGFKQSSNLYCTL BCR_Hsap TSVELQMLTNSCVKLQ-TVHSIPLTINKEDDESPGLYGFLNVIVHSATGFKQSSNLYCTL BCR_Spur TPYHVSKLIPKTRRGRDSYVNISSVLLKDNDEL--LTGMLHVTVKEARGLTVPSQLYCCL RhoGAP1A_Dmel NSLEVTAFIVAMQKGMKTEMG-SYLMRNTNDES-LLVGDLYMGVHGLEGLEQANDLYICV ABR_Hsap SSVELQVLTGSCFKLR-TVHNIPVTSNKDDDESPGLYGFLHVIVHSAKGFKQSANLYCTL ABR_Mmus SSVELQVLTGSCFKLR-TVHNIPVTSNKDDDESPGLYGFLHVIVHSAKGFKQSANLYCTL .. .: : : : . : :** * * * : *: *: . :** : BCR_Mmus EVDSFGYFVNKAKTRVYRDTTEPNWNEEFEIELEGSQTLRILCYEKCYNKMKMTKEDGES BCR_Hsap EVDSFGYFVNKAKTRVYRDTAEPNWNEEFEIELEGSQTLRILCYEKCYNKTKIPKEDGES BCR_Spur ETDAYGIFSRMAKTRKTANTITPKWNEEFALDVDGARTLRILCYDFTKG----------L RhoGAP1A_Dmel EVDSYGHYFRKATTKKICRSQTPLWNESFMLELEGSQNVRILLYEAKE------------ ABR_Hsap EVDSFGYFVSKAKTRVFRDTAEPKWDEEFEIELEGSQSLRILCYEKCYDKTKVNKDNNEI ABR_Mmus EVDSFGYFVSKAKTRVFRDTTEPKWDEEFEIELEGSQSLRILCYEKCYDKTKVNKDNNEI *.*::* : *.*: : * *:*.* ::::*::.:*** *: BCR_Mmus ADKLMGKGQVQLDPQTLQDRDWQRTVIDM------------------------------- BCR_Hsap TDRLMGKGQVQLDPQALQDRDWQRTVIAM------------------------------- BCR_Spur DDEMYDKGAVSLTKQNISSPGGMDCTIQMDQCSDFLKMWRFCLVVYAYARNNLFGCIGIP RhoGAP1A_Dmel RPLLKAKHILKLSLSWLTETTQPKSIKLT------------------------------- ABR_Hsap VDKIMGKGQIQLDPQTVETKNWHTDVIEM------------------------------- ABR_Mmus VDKIMGKGQIQLDPQTVESKNWHTDVIEM------------------------------- : * :.* . : BCR_Mmus --------NGIEVKLSVKFTSREFSLKRMPSRKQTGVFGVKIAVVTKRERSKVPYIVRQC BCR_Hsap --------NGIEVKLSVKFNSREFSLKRMPSRKQTGVFGVKIAVVTKRERSKVPYIVRQC BCR_Spur SVKLKTQDDSLQVDVTVRFETSERTLKRVQSRKKMGVFGVHVGTLAHRQGKNIPNIITLC RhoGAP1A_Dmel --------ETLELGCSFRFIPGEL--FR-GSTKPGALFGAKMSQVLKREKRDIPFIIGAC ABR_Hsap --------NGIKVEFSMKFTSRDMSLKRTPSKKQTGVFGVKISVVTKRERSKVPYIVRQC ABR_Mmus --------NGIKVEFSMKFTSRDMSLKRTPSKKQTGVFGVKISVVTKRERSKVPYIVRQC : ::: :.:* . : * * * .:**.::. : :*: .:* *: * BCR_Mmus VEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNKDVSVMMSEMDVNAIAGTLKLYFRE BCR_Hsap VEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNKDVSVMMSEMDVNAIAGTLKLYFRE BCR_Spur VEEIDRRGVHEMGIYRISGSSADIQKLKKAFEQNRRNITAMLKQSDIHAVAGLLKSYLRE RhoGAP1A_Dmel IREVERRGMLEVGCYRVSGSASDLAKLKKAFESDAYEAEQLLREVDIHSVTGILKTFLRE ABR_Hsap VEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNKDILLMLSDMDINAIAGTLKLYFRE ABR_Mmus IEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNKDILLMLSDMDINAIAGTLKLYFRE :.*:::**: *:* **:** ::*: ** .*: : : :: : *:::::* ** ::** BCR_Mmus LPEPLFTDEFYPNFAEGIAL---SDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAE BCR_Hsap LPEPLFTDEFYPNFAEGIAL---SDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAE BCR_Spur LPEPLFTHVLYPQFVDGLQL---TDPVAKKKCFLSLLKNVVEPNRTIIFLIFNHLRRIAK RhoGAP1A_Dmel LPEALFTDQLYPRFFDTFSAFSNNNESTRINELLKVFEELPQANKASITSILDHLIRVHE ABR_Hsap LPEPLLTDRLYPAFMEGIAL---SDPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAE ABR_Mmus LPEPLLTDRLYPAFMEGIAL---SDPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAE ***.*:*. :** * : : .: :: . :: :: .: :.* : :::** *: : BCR_Mmus KETVNKMSLHNLATVFGPTLLRPSEKESKLPANPSQPITMTDSW-SLEVMSQVQVLLYFL BCR_Hsap KEAVNKMSLHNLATVFGPTLLRPSEKESKLPANPSQPITMTDSW-SLEVMSQVQVLLYFL BCR_Spur EEEKNKMNLHNLSTVFGPTLLGPAATISATG----KPDILAEIMGMSSVISQVGILHYCL RhoGAP1A_Dmel KETDNKMSLHNLAMVFGPTLLRPGQTQVKQKD-----PLAA---STVDVMAQAGILYCFL ABR_Hsap KEPINKMSLHNLATVFGPTLLRPSEVESKAHL-----TSAADIW-SHDVMAQVQVLLYYL ABR_Mmus KEPINKMSLHNLATVFGPTLLRPSEVESKAHL-----TSAADIW-SHDVMAQVQVLLYYL :* ***.****: ******* *. : .*::*. :* * BCR_Mmus QLEAIPAPDSKRQSILFSTEV BCR_Hsap QLEAIPAPDSKRQSILFSTEV BCR_Spur EHFSESV-------EILETDL RhoGAP1A_Dmel QARI--------------KKD ABR_Hsap QHPPISFAELKRNTLYFSTDV ABR_Mmus QHPPISFAELKRNTLYFSTDV : ..