CLUSTAL W (1.83) multiple sequence alignment BRDT_Mmus MSLPSRQT---------------------------------------------------- BRD4_Mmus MSTESGP----------------------------------------------------- BRD3_Mmus MSTTAA------------------------------------------------------ BRD2_Mmus MLQNVTPHK-LP-GE-GNA--G-LLGLG-------------------------------- BRD2_Hsap MLQNVTPHNKLP-GE-GNA--G-LLGLG-------------------------------- BRD3_Hsap MSTATTV----------------------------------------------------- BRD4_Hsap MSAESGP----------------------------------------------------- BRDT_Hsap MSLPSRQT---------------------------------------------------- Y119C1B.8_Cele MSEGSGDQSQQR-PW--------------------------------------------- DDB0220693_Ddis MSLEQQDETVV-EEETKTSFETNNSTANNTNNNTDNTYKEEILKSTESIT--------RN DDB0220694_Ddis MSNKTLPYCCE-HGL-KDEVIA-LLAKGEDVNQ-------------KDGS---------- BRD_Spur ------------------------------------------------------------ F13C5.2_Cele MPTTRSA----------------------------------------------------- F57C7.1b_Cele MSDYSAKPSGSLARI-G--DYD-LSSDDSDQND-------------EDETLIASKTIQTG AqueK041_Aque MMEQNVSPPRLE-SRSS-SATP-MLNPGLVATQ--------------------------- BRDT_Mmus ------------------------------------------------------------ BRD4_Mmus ------------------------------------------------------------ BRD3_Mmus ------------AP---------------------------------------------- BRD2_Mmus --------PEAAAP---------------------------------------------- BRD2_Hsap --------PEAAAP---------------------------------------------- BRD3_Hsap ------------AP---------------------------------------------- BRD4_Hsap ------------------------------------------------------------ BRDT_Hsap ------------------------------------------------------------ Y119C1B.8_Cele -----------ASPR------------------------------------Q-------- DDB0220693_Ddis --------DDKVDPTSATALE--------------------------------------- DDB0220694_Ddis ----------NRYPLHYAAIG---GYIEIVAML----------------LER-------- BRD_Spur ------------------------------------------------------------ F13C5.2_Cele ------------------------------------------------------------ F57C7.1b_Cele AVQVNDIAVAEASPAETD--------------A----------------KSS-------- AqueK041_Aque -----------ATPTTVPAMLVQSGN------VQNVSFQQQGGGGINSVPTNLTSYTSII BRDT_Mmus ------------------------------------------------------------ BRD4_Mmus ------------------------------------------------------------ BRD3_Mmus ------------------------------------------------------------ BRD2_Mmus ------------------------------------------------------------ BRD2_Hsap ------------------------------------------------------------ BRD3_Hsap ------------------------------------------------------------ BRD4_Hsap ------------------------------------------------------------ BRDT_Hsap ------------------------------------------------------------ Y119C1B.8_Cele ---------------QP-----IKGIVQP------------------------------- DDB0220693_Ddis ---------------KD----I-INNGEYSGS------------------------SSSS DDB0220694_Ddis ---------------GA----L-VNCSTPRGA------------------------TPLH BRD_Spur ------------------------------------------------------------ F13C5.2_Cele -----------------------NHPAPK------------------------------- F57C7.1b_Cele ---------------AS----PVSGPEPPTSAVVENRDLDEFKKESGSNDDKQEEINEDK AqueK041_Aque DPSQLLVKTEGVTSASPLSVGGANRTTPPTL-V----------------------TG--- BRDT_Mmus ------------------------------------------------------------ BRD4_Mmus -----------------------------------GTRLRNL------------------ BRD3_Mmus ------------------------------------------------------------ BRD2_Mmus -----------------------------------GKRIRKP------------------ BRD2_Hsap -----------------------------------GKRIRKP------------------ BRD3_Hsap ------------------------------------------------------------ BRD4_Hsap -----------------------------------GTRLRNL------------------ BRDT_Hsap ------------------------------------------------------------ Y119C1B.8_Cele ------------------------------------------------------------ DDB0220693_Ddis GN-------------------------------NNINGSNNIKNIV-------------- DDB0220694_Ddis YA-------------------------------SRGGRIECIQLLIDNKADVNCRD-GAG BRD_Spur ------------------------------------------------------------ F13C5.2_Cele ------------------------------------------------------------ F57C7.1b_Cele DS-------------------------------NEETVFQQTESGSADVVDKTDVKQKDS AqueK041_Aque -TGSITATPTAYTTAVTTSATSTTTVGGVTGGSILGKRIRRT------------------ BRDT_Mmus ------------------------------------------------------------ BRD4_Mmus -------------------------------------------------------PVMGD BRD3_Mmus ------------------------------------------------------------ BRD2_Mmus -------------------------------------------------------SLLYE BRD2_Hsap -------------------------------------------------------SLLYE BRD3_Hsap ------------------------------------------------------------ BRD4_Hsap -------------------------------------------------------PVMGD BRDT_Hsap ------------------------------------------------------------ Y119C1B.8_Cele ------------------------------------------------------------ DDB0220693_Ddis ---------IEKVEQ--------------------------------------------- DDB0220694_Ddis STPLHTALQCNETKCAIALIET---FGADV--NLKTAEGSTALHLASARGLVPVI----- BRD_Spur ------------------------------------------------------------ F13C5.2_Cele ------------------------------------------------------------ F57C7.1b_Cele DSSADDDH-------------SHSKSGSVHSPQKPQGSTTPCSVQSPASPVGDEQAVKME AqueK041_Aque -------------------------------------------------------STKYD BRDT_Mmus ------------------------------------------------------------ BRD4_Mmus GLETSQMSTTQAQA--------------------------------------------QP BRD3_Mmus ----------------------------------------------------------TG BRD2_Mmus GFESPTM---------------------------------------------------AS BRD2_Hsap GFESPTM---------------------------------------------------AS BRD3_Hsap ----------------------------------------------------------AG BRD4_Hsap GLETSQMSTTQAQA--------------------------------------------QP BRDT_Hsap ------------------------------------------------------------ Y119C1B.8_Cele ------------------------------------------------------------ DDB0220693_Ddis -----------------------------------------------LERV----VVNNN DDB0220694_Ddis --------------------------------------------VALLENG----ARADV BRD_Spur ------------------------------------------------------------ F13C5.2_Cele ------------------------------------------------------------ F57C7.1b_Cele EVEEPIVASEEVPDKKPESVKESTDSESSGSEHGFEKMDTAEKVEDECNDDEVAASNGTE AqueK041_Aque DFEQPLMRPSKVEA---------------------------------------------- BRDT_Mmus -----A-IVN------PP--------------PPEYI---N-TKKSGRLTN--------- BRD4_Mmus QPAN-AASTN------PP--------------PPETS---N-PNKPKRQTN--------- BRD3_Mmus IPAV-PGPVN------PP--------------PPEVS---N-PSKPGRKTN--------- BRD2_Mmus VPALQLAPAN------PP--------------PPEVS---N-PKKPGRVTN--------- BRD2_Hsap VPALQLTPAN------PP--------------PPEVS---N-PKKPGRVTN--------- BRD3_Hsap IPAT-PGPVN------PP--------------PPEVS---N-PSKPGRKTN--------- BRD4_Hsap QPAN-AASTN------PP--------------PPETS---N-PNKPKRQTN--------- BRDT_Hsap -----AIIVN------PP--------------PPEYI---N-TKKNGRLTN--------- Y119C1B.8_Cele ----------------------------------RVL---PPFGKPTRHTN--------- DDB0220693_Ddis NGDENNKDIHDSSNNTE---------------DIDI---------------------SKS DDB0220694_Ddis RDSKENSPFQS-----L---------------PINLT---ENE-KKEKIENSISQDISKL BRD_Spur ------------------------------------------------------------ F13C5.2_Cele ----------------------------------RAI---SP-DSDDGE----------- F57C7.1b_Cele EPEPGDKAADT-----VNPWETPRQEPVDGVVQPRTE---PPAGKPTRHTN--------- AqueK041_Aque KE---SSETRE-----KT--------------PSEKTTEEEGKGGGNRSTN--------- BRDT_Mmus -------------------------------------------------QLQFLQRVVLK BRD4_Mmus -------------------------------------------------QLQYLLRVVLK BRD3_Mmus -------------------------------------------------QLQYMQNVVVK BRD2_Mmus -------------------------------------------------QLQYLHKVVMK BRD2_Hsap -------------------------------------------------QLQYLHKVVMK BRD3_Hsap -------------------------------------------------QLQYMQNVVVK BRD4_Hsap -------------------------------------------------QLQYLLRVVLK BRDT_Hsap -------------------------------------------------QLQYLQKVVLK Y119C1B.8_Cele -------------------------------------------------KLDYIMTTVLK DDB0220693_Ddis H-IIKYDKDEMSTIST-IHYSD-DESSKEKQ---------DNINSNNNNNKNKNE----- DDB0220694_Ddis FNINKN-REFSGVGKKEDDDNNMKIDKQESEQQSTSDKLYSDITFLIENQKVYAHKCILQ BRD_Spur ------------------------------------------------------------ F13C5.2_Cele ------------------------------------------------------------ F57C7.1b_Cele -------------------------------------------------CLDFVLFTVVK AqueK041_Aque -------------------------------------------------QLQYLKN-VHR BRDT_Mmus ALWKHGFSWPFQQPVDAVKLKLPDYYTIIKTPMD-------------------------- BRD4_Mmus TLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMD-------------------------- BRD3_Mmus TLWKHQFAWPFYQPVDAIKLNLPDYHKIIKNPMD-------------------------- BRD2_Mmus ALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMD-------------------------- BRD2_Hsap ALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMD-------------------------- BRD3_Hsap TLWKHQFAWPFYQPVDAIKLNLPDYHKIIKNPMD-------------------------- BRD4_Hsap TLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMD-------------------------- BRDT_Hsap DLWKHSFSWPFQRPVDAVKLQLPDYYTIIKNPMD-------------------------- Y119C1B.8_Cele EAGKHKHVWPFQKPVDAVALCIPLYHERVARPMD-------------------------- DDB0220693_Ddis --------------------QIINSENILDTPMTEASDQTTPSDTPPTLTNNTSSTTTTT DDB0220694_Ddis A-------------------RCPNFMSSINNKIE-------------------------- BRD_Spur ------------HPVDPTKLALPDYFKIIKTPMD-------------------------- F13C5.2_Cele ----------------------EDDFKSKRT----------------------------- F57C7.1b_Cele DALKHKHSWPFQLPVDAIKLEIPEYHNIVNTPMD-------------------------- AqueK041_Aque IIWRHHYAWPFHKPVDPVALNIPDYFNIIKRPMD-------------------------- BRDT_Mmus ----------LNTIKKRLENKYY----------EKASECIEDFNTMF------------- BRD4_Mmus ----------MGTIKKRLENNYY----------WNAQECIQDFNTMF------------- BRD3_Mmus ----------MGTIKKRLENNYY----------WSASECMQDFNTMF------------- BRD2_Mmus ----------MGTIKRRLENNYY----------WAASECMQDFNTMF------------- BRD2_Hsap ----------MGTIKRRLENNYY----------WAASECMQDFNTMF------------- BRD3_Hsap ----------MGTIKKRLENNYY----------WSASECMQDFNTMF------------- BRD4_Hsap ----------MGTIKKRLENNYY----------WNAQECIQDFNTMF------------- BRDT_Hsap ----------LNTIKKRLENKYY----------AKASECIEDFNTMF------------- Y119C1B.8_Cele ----------LKTIENRLKSTYY----------TCAQECIDDIETVF------------- DDB0220693_Ddis TTNNTTTAATTTTNSRRKRNSLS----------TPSSEMDPVLDSTS------------- DDB0220694_Ddis ----------QQQSQKPIEIKDYSFKLFLSFIEWIYTGSIEKFESTSKSIDLSFQFSILL BRD_Spur ----------LGTIKKRLESIYY----------HSAKECISDFNLMF------------- F13C5.2_Cele ------------------------------------------------------------ F57C7.1b_Cele ----------LRTIEKRLRNLYY----------WCAEDAIKDLNTLF------------- AqueK041_Aque ----------LTLIKKQLDHNGY----------SSAKECIQDFKTMF------------- BRDT_Mmus ----------------------------------------SNCYL--------YNKTGDD BRD4_Mmus ----------------------------------------TNCYI--------YNKPGDD BRD3_Mmus ----------------------------------------TNCYI--------YNKPTDD BRD2_Mmus ----------------------------------------TNCYI--------YNKPTDD BRD2_Hsap ----------------------------------------TNCYI--------YNKPTDD BRD3_Hsap ----------------------------------------TNCYI--------YNKPTDD BRD4_Hsap ----------------------------------------TNCYI--------YNKPGDD BRDT_Hsap ----------------------------------------SNCYL--------YNKPGDD Y119C1B.8_Cele ----------------------------------------QNCYT--------FNGKEDD DDB0220693_Ddis ----------------------------------------ENNTTRKTRGSRNSKKEPEE DDB0220694_Ddis MGEKFDCKGLVSYCREFIKESIGDSNVGSIWSIIKKLPTSTRSNL--------GNLVRDC BRD_Spur ----------------------------------------TNCYV--------YNKPGED F13C5.2_Cele ------------------------------------------------------------ F57C7.1b_Cele ----------------------------------------DNCKK--------FNDRNDD AqueK041_Aque ----------------------------------------NNCYT--------YNKPTDD BRDT_Mmus IVVMAQALEK--------LFMQKLSQMPQEEQ-VVGG----------------K-ERIKK BRD4_Mmus IVLMAEALEK--------LFLQKINELPTEET-EIMIVQA-------------K-GRGRG BRD3_Mmus IVLMAQALEK--------IFLQKVAQMPQEEV-ELLPPAP-------------K-GKGRK BRD2_Mmus IVLMAQTLEK--------IFLQKVASMPQEEQ-ELVVTIP-------------K-NSHKK BRD2_Hsap IVLMAQTLEK--------IFLQKVASMPQEEQ-ELVVTIP-------------K-NSHKK BRD3_Hsap IVLMAQALEK--------IFLQKVAQMPQEEV-ELLPPAP-------------K-GKGRK BRD4_Hsap IVLMAEALEK--------LFLQKINELPTEET-EIMIVQA-------------K-GRGRG BRDT_Hsap IVLMAQALEK--------LFMQKLSQMPQEEQ-VVGV----------------K-ERIKK Y119C1B.8_Cele VTIMAQNVHE--------VIKKSLEQAPREEH-DMDVYWG-------------K-NKKK- DDB0220693_Ddis LLLTPEQAKELSNKSKKWIYVPIIEAEAKKEE-VLPAKRDRKQVFNENIFSSSRKSTTKG DDB0220694_Ddis LITMVRSWNIF--------TMTKTFSTDINKSDIIEIIKSLAPFI----TETPI-SEIKQ BRD_Spur VVLMAQALEK--------LFLTKVAQMPQEEI-ELAPPVK--PGMGDDI-SGPG-RKGRK F13C5.2_Cele ----------------------------------------------------PS-GRGRG F57C7.1b_Cele IYIMCENIEG--------VVQRGLEWMPSEEK-PADLADHHRRGMFSA--STPS-GKTKG AqueK041_Aque VVFMCQALER--------LFDQKVTGMPAEEF-EIVPGQ-----------------KGRK : BRDT_Mmus ----DIQ-QKI-----AVSSAKEQIP-SK-A-AEN-VFKRQ------EIPSGL------- BRD4_Mmus ----R-K-ETGAAKPG-VSTVPNTTQ-AS-T-SPQTQTPQQ------NPPPPVQATT--- BRD3_Mmus ----P---AAGAQNAG----SQQVAA-VS-S-VSP-ATPFQ------NIPPTVSQTPVIA BRD2_Mmus ----G---AKLAALQGSITSAHQVPA-VS-S-VSH--TALY------TPPPEIPTTV--L BRD2_Hsap ----G---AKLAALQGSVTSAHQVPA-VS-S-VSH--TALY------TPPPEIPTTV--L BRD3_Hsap ----P---AAGAQSAG----TQQVAA-VS-S-VSP-ATPFQ------SVPPTVSQTPVIA BRD4_Hsap ----R-K-ETGTAKPG-VSTVPNTTQ-AS-T-PPQTQTPQP------NP-PPVQATP--- BRDT_Hsap ----GTQ-QNI-----AVSSAKEKSS-PS-A-TEK-VFKQQ------EIPSVF------- Y119C1B.8_Cele ----PAK-SDGGSKS---SSSKK----ND-A-RGPSEAPSEAGSEVS------------- DDB0220693_Ddis GEKKNDTASTTNTPI---ITAQQNTTPLSPTQTTTTTTTPTTTTAQQ------------- DDB0220694_Ddis TRTANANASNSNQSK---TPAKR----TSTT-NTNNNIPQQNITSSN------------- BRD_Spur GRVPGRG-ISANSRLG-IQNASP----QP-S------VPNAATTQ-LPGPPAKNAYVAPL F13C5.2_Cele GRGRGRG-RGRGGAT---AA-------GATV-EGGES--------TR------------- F57C7.1b_Cele PKQRGRK-STRGRKK---TSLPR----GAST-FKDESVDDNNDDESS------------- AqueK041_Aque ---PGPK-SNAGRRT---KMAAA----ES-T------VNLDSPGD--------------- BRDT_Mmus ----PDI----S-----------------------------------LSPLN-------- BRD4_Mmus -HPFPAVTPDLIAQPPVMTMVPPQPLQTPS----------PV-PPQPPPPPA-------- BRD3_Mmus ATPVPTITANVT--------------S--V----------PV-PPPAAPPP--------- BRD2_Mmus NIPHPSVISSPL--------------L--K----------S--LHSAGPPL--------- BRD2_Hsap NIPHPSVISSPL--------------L--K----------S--LHSAGPPL--------- BRD3_Hsap ATPVPTITANVT--------------S--V----------PV-PPAAAPPP--------- BRD4_Hsap -HPFPAVTPDLIVQTPVMTVVPPQPLQTPP----------PV-PPQPQPPPA-------- BRDT_Hsap ----PKT----S-----------------------------------ISPLN-------- Y119C1B.8_Cele SVTT---------------------------------------ASA-AAPTVSE------ DDB0220693_Ddis NTPAQTESKPP----TTISINIKGS-KSPKTTGGKQQKPTPPSPVVISQPVVPSTPVVAT DDB0220694_Ddis NTPQ---------------------------------------QNT------SSSSSSST BRD_Spur AMKSPTATQPS----TELPVLPPGAASTQA----------TA-AAMSTSPLVSS------ F13C5.2_Cele GG--------------------------------------------------------GT F57C7.1b_Cele KVDS---------------------------------------IN-F-----DDDDDTAT AqueK041_Aque -------------------------VSLVS----------ST-SSTVQPPLV-------- BRDT_Mmus -----------------------------------M--A--------------------- BRD4_Mmus --------------------PVP-----------QP--V--------------------- BRD3_Mmus -----------------------------------P--A--------------------- BRD2_Mmus -----------------------------------L--A--------------------- BRD2_Hsap -----------------------------------L--A--------------------- BRD3_Hsap -----------------------------------P--A--------------------- BRD4_Hsap --------------------PAP-----------QP--V--------------------- BRDT_Hsap -----------------------------------V--V--------------------- Y119C1B.8_Cele ----------------------SASVA--------------------------------- DDB0220693_Ddis TKKTNSRSKRSTANNNSETTQTPEVVISAPTTTTAAITTPINITPSSDSATIQQLQQSIS DDB0220694_Ddis TS---------------------------------------------------------- BRD_Spur --------------------PPPISTP------VEP--VKQNS----------------- F13C5.2_Cele -----GRGGR-------------------------------------------------- F57C7.1b_Cele EKDAESRAES----------VQPEVVN--------------------------------- AqueK041_Aque --------------------PAPLSTT--------------------------------- BRDT_Mmus -------------------------------------------------------QEAPP BRD4_Mmus -------------------------------------------------------QSHPP BRD3_Mmus -------------------------------------------------------TPIVP BRD2_Mmus ----------------------------------------------------------VS BRD2_Hsap ----------------------------------------------------------VT BRD3_Hsap -------------------------------------------------------TPIVP BRD4_Hsap -------------------------------------------------------QSHPP BRDT_Hsap -------------------------------------------------------QGASV Y119C1B.8_Cele ------------------------------------------------------------ DDB0220693_Ddis MLEDKIRLISSNNKVATEILNNTITTTTTTAATSAIKDEEIIENTELQTTFTKSSTLAPP DDB0220694_Ddis ------------------------------------------------------------ BRD_Spur -------------------------------------------------------LPGPP F13C5.2_Cele ------------------------------------------------------------ F57C7.1b_Cele ------------------------------------------------------------ AqueK041_Aque ------------------------------------------------------------ BRDT_Mmus ------------------------------I-CDSQSLVQITK--GVKRRADTTTPTTSI BRD4_Mmus ------------------------------IIATTPQPVKTKK--GVKRKADTTTPTTID BRD3_Mmus ------------------------------VV-PPTPPVVKKK--GVKRKADTTTPTTSA BRD2_Mmus ------------------------------AA-PPAQPLAKKK--GVKRKADTTTPTPTA BRD2_Hsap ------------------------------AA-PPAQPLAKKK--GVKRKADTTTPTPTA BRD3_Hsap ------------------------------VV-PPTPPVVKKK--GVKRKADTTTPTTSA BRD4_Hsap ------------------------------IIAATPQPVKTKK--GVKRKADTTTPTTID BRDT_Hsap ------------------------------N-SSSQTAAQVTK--GVKRKADTTTPATSA Y119C1B.8_Cele --------------------------------AKPERKVAGKK--TGKRKAESEDDEK-- DDB0220693_Ddis SSERKYSNLYSDDEDDTEMVDVSVSIPIPIPIPTPTQTTTKKTTLSKKRKSNTSTIIPTT DDB0220694_Ddis ---------------------------------------------STPSKSSSSTPSKST BRD_Spur ------------------------------KVRS-PAKTKGAR--GVKRKADTTTPTTVI F13C5.2_Cele ---------------------------------------------GRPRGSKN------- F57C7.1b_Cele --------------------------------EEPKPSTSQPP--SKKRKAENGEPAVAV AqueK041_Aque -----------------------------------TQPVIKRK--GVKRQADTTTPHSGQ :.. BRDT_Mmus AKA-SS------ESPPT---L-----RETKPVNM-PVKENT------VKNVLPDSQ---- BRD4_Mmus PIHE---------PPSL---A-----PEPKTAKLGPRR-ESSRPVKPPKKDVPDSQ---- BRD3_Mmus ITASRS------ESPPP---L-----SEPKQAKVVARRESGGRPIKPPKKDLEDGE---- BRD2_Mmus ILAPGS--P---ASPPG---S-----LEPKAARLPPMRRESGRPIKPPRKDLPDSQ---- BRD2_Hsap ILAPGS--P---ASPPG---S-----LEPKAARLPPMRRESGRPIKPPRKDLPDSQ---- BRD3_Hsap ITASRS------ESPPP---L-----SDPKQAKVVARRESGGRPIKPPKKDLEDGE---- BRD4_Hsap PIHE---------PPSL---P-----PEPKTTKLGQRR-ESSRPVKPPKKDVPDSQ---- BRDT_Hsap VKA-SS------EFSPT---F-----TE-KSVALPPIKENM------PKNVLPDSQ---- Y119C1B.8_Cele --------------PEPLR---A------KRE-----V-------AVVKKEV-------- DDB0220693_Ddis TIQQEQGQEQGQQQPPQQQ---Q-P----PQQ-----Q-------QPPQQQQPPQQQPPQ DDB0220694_Ddis STSSSS------SSSSS-------------------------------------SSSS-- BRD_Spur EP-PE---P-I-VAPSADYHL-----AQAKPAKIPGRRESSRRNIKPPNRELPESD---- F13C5.2_Cele SD-GG------------AG---G-P----PA------K--------RGRKKKAKSE---- F57C7.1b_Cele KI-ATP------ATP--VA---A-H----PQ------E-------ETPRRKNPNTLIE-- AqueK041_Aque PS-PTSGVP-L-DQPPPPAVVVASTPVHILSSAVPTRRES-TRTIKRPKLDLPGES---- BRDT_Mmus ------------------------------------------------------------ BRD4_Mmus ------------------------------------------------------------ BRD3_Mmus ------------------------------------------------------------ BRD2_Mmus ------------------------------------------------------------ BRD2_Hsap ------------------------------------------------------------ BRD3_Hsap ------------------------------------------------------------ BRD4_Hsap ------------------------------------------------------------ BRDT_Hsap ------------------------------------------------------------ Y119C1B.8_Cele ------------------------------------------------------------ DDB0220693_Ddis QSTSPSKTQQENTSSTTTTTTTTTTTTNTEDTTTVIDKKPKKKPRHSAPLIPQIKPRLPL DDB0220694_Ddis ------------------------------------------------------------ BRD_Spur ------------------------------------------------------------ F13C5.2_Cele ------------------------------------------------------------ F57C7.1b_Cele --------W--------------------------------------------------- AqueK041_Aque ------------------------------------------------------------ BRDT_Mmus ------QQHK--------VLKTVKVTEQLKHCSEILKEMLAKKHLPYAWPFYNPVDADAL BRD4_Mmus ------QHPG--------PEKSSKISEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEAL BRD3_Mmus ------VPQH--------AGKKGKLSEHLRHCDSILREMLSKKHAAYAWPFYKPVDAEAL BRD2_Mmus ------QQHQ--------SSKKGKLSEQLKHCNGILKELLSKKHAAYAWPFYKPVDASAL BRD2_Hsap ------QQHQ--------SSKKGKLSEQLKHCNGILKELLSKKHAAYAWPFYKPVDASAL BRD3_Hsap ------VPQH--------AGKKGKLSEHLRYCDSILREMLSKKHAAYAWPFYKPVDAEAL BRD4_Hsap ------QHPA--------PEKSSKVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEAL BRDT_Hsap ------QQYN--------VVKTVKVTEQLRHCSEILKEMLAKKHFSYAWPFYNPVDVNAL Y119C1B.8_Cele ---------------------HQPLLPSMKPCLKLLNDFSTKKYQEFAWPFNEPVDAEQL DDB0220693_Ddis NGGSSERAQRSSRGRMGKAMRDVVLTPVFKRCLDLLEELFEHQHS---PPFLVAVDPYAL DDB0220694_Ddis -------SSS--------NYSDSMNEKNLTFCKGLINGMFKKKTS---LAFQRPVDPLAE BRD_Spur ------QHQK---------GKKGKLTAQLKYCYGVIKELMSKKHSAYAWPFFKPVDADVL F13C5.2_Cele ------SEDE---------AESDHLHDELKKCLSILKEFEKSTHDSFTFPFRKPVDVVLL F57C7.1b_Cele ------KHLV--------PRWQGKIPEWQKFCSKLLNEIHSVKNKGFAQVFYLPVDPIKL AqueK041_Aque --------SY---------GRKRPLTVQLRYCLSIVKDFFSKKHQASAWPFYNPVDVKGL * ::. : * .** BRDT_Mmus GLHNYYDVVKNPMDLGTIKGKMDNQEYKDAYEFAADVRLMFMNCYKYNPPDHEVVAMART BRD4_Mmus GLHDYCDIIKHPMDMSTIKSKLESREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARK BRD3_Mmus ELHDYHDIIKHPMDLSTVKRKMDSREYPDAQGFAADIRLMFSNCYKYNPPDHEVVAMARK BRD2_Mmus GLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARK BRD2_Hsap GLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARK BRD3_Hsap ELHDYHDIIKHPMDLSTVKRKMDGREYPDAQGFAADVRLMFSNCYKYNPPDHEVVAMARK BRD4_Hsap GLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARK BRDT_Hsap GLHNYYDVVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPDHEVVTMARM Y119C1B.8_Cele GLHDYHKIIKEPMDLKSMKAKMESGAYKEPSDFEHDVRLMLRNCFLYNPVGDPVHSFGLR DDB0220693_Ddis GILDYFDVIKHPMDLGTIKASLIGGGYDTIDKFAEDCRLVFSNAKTYNPSTNPVHIMAQS DDB0220694_Ddis GIPDYFDVIKHPMDLGTIKGKLDNNGYSTIKDFAADVRLMFENALTYNADSSPVWKHAKT BRD_Spur GLHDYHEIIKTPMDMGTVKVKLENRDYKNANDFAANVRLIFTNCYKYNPPDHDVVGMARK F13C5.2_Cele GLTDYHEVIKKPMDMSTIRKKLIGEEYDTAVEFKEDFKLMINNCLTYNNEGDPVADFALQ F57C7.1b_Cele KIYDYLEVITNPMDLQTIKKKLDFKQYAEPEEFVHDINLMVDNCCKYNPKGSPAHSNALE AqueK041_Aque GLHDYLDIIKQPMDLTTLKKKLEDREYEDPSQFAADMRLIFTNCYKYNPPEHDVVKMARK : :* .::. ***: ::: .: * * : .*:. *. ** . . BRDT_Mmus LQDVFELHFAKI-PDEPIE--SMHACHLTT------NSAQALSRESSSEASSG------- BRD4_Mmus LQDVFEMRFAKM-PDEPEE--PVVTVSSPAVPPPTKVVAPPSSSDSSSDSSSDS------ BRD3_Mmus LQDVFEMRFAKM-PDEPME--APALPAPTA-P----IVSKGAESSRSSEESSSD------ BRD2_Mmus LQDVFEFRYAKM-PDEPLE--PGPLPVSTALP----PGLTKSSSESSSEESSSESSSEEE BRD2_Hsap LQDVFEFRYAKM-PDEPLE--PGPLPVSTAMP----PGLAKSSSESSSEESSSESSSEEE BRD3_Hsap LQDVFEMRFAKM-PDEPVE--APALPAPAA-P----MVSKGAESSRSSEESSSD------ BRD4_Hsap LQDVFEMRFAKM-PDEPEE--PVVAVSSPAVPPPTKVVAPPSSSDSSSDSSSDS------ BRDT_Hsap LQDVFETHFSKI-PIEPVE--SMPLCYIKT------DITETTGRENTNEASSE------- Y119C1B.8_Cele FQEVFDRRWAEL-GDSSSR--ASSVAPQSAPIAPTPK-VAKSSAPKEPKESRKEHKKE-- DDB0220693_Ddis LEDVFEKGFPK-VLIEPPS--PPPKNVD------QE--KIE--K-LSN-----DL----- DDB0220694_Ddis LLNAFDQKFLQNFPNEKPPTYKPPPPTP------TP--IPT--Q-QQQQQSTSST----- BRD_Spur LQNVFEVKFAKM-PDEPLD--PSDLESDD-E-SK-D--ETKAMD-SPSDASASNS----- F13C5.2_Cele FRKKFAAKWKKEFPEDG--------------------------D-SFGQEKGEKE----- F57C7.1b_Cele LRSFFEQRWKLF-PRPGVD--PIIADSY--I--NQN--LVVNTD-LIEDERINSY----- AqueK041_Aque VQDIFEFKFARM-PEEPPP--APPKKTS--I-KM-K--TGGSSD-SSSSESEDND----- . . * : BRDT_Mmus -----------DASSEDSEDERVQHLAK--LQEQ-----------------LNAVHQQLQ BRD4_Mmus -----------DSSTDDSEEERAQRLAE--LQEQ-----------------LKAVHEQLA BRD3_Mmus ------------SGSSDSEEERATRLAE--LQEQTGCGAFQDQLLNVSSVQLKAVHEQLA BRD2_Mmus EEE-EEDEDEEESESSDSEEERAHRLAE--LQEQ-----------------LRAVHEQLA BRD2_Hsap EEEDEEDEEEEESESSDSEEERAHRLAE--LQEQ-----------------LRAVHEQLA BRD3_Hsap ------------SGSSDSEEERATRLAE--LQEQ-----------------LKAVHEQLA BRD4_Hsap -----------DSSTDDSEEERAQRLAE--LQEQ-----------------LKAVHEQLA BRDT_Hsap -----------GNSSDDSEDERVKRLAK--LQEQ-----------------LKAVHQQLQ Y119C1B.8_Cele ----------TTFEASGAKS---EDLMQ--INNA-----------------LSMIREREE DDB0220693_Ddis ----------------------------------------------------KNVTKELE DDB0220694_Ddis ------------------------------------------------------------ BRD_Spur -----------SSESEDSEEEREKRLSE--LQEQ-----------------LKAVHEQLA F13C5.2_Cele -----------GSD-NEDDE---EEVDEKEKEEE-----------------V-------- F57C7.1b_Cele -----------LSA-VKAEE---KKCAE--KLEQ-----------------LRSMSEGLY AqueK041_Aque -----------SSEESDSESERASQLSK--LQEQ-----------------VIMVSKQLA BRDT_Mmus VLSQV----------------PLRKLKKK--------NE-KSK----------------- BRD4_Mmus ALSQP----------------QQNKPKKK---------E-KDK----------------- BRD3_Mmus ALSQA----------------PVNKPKKK--------KE-KKE----------------- BRD2_Mmus ALSQG----------------PISKPKRK--------RE-KKE----------------- BRD2_Hsap ALSQG----------------PISKPKRK--------RE-KKE----------------- BRD3_Hsap ALSQA----------------PVNKPKKK--------KE-KKE----------------- BRD4_Hsap ALSQP----------------QQNKPKKK---------E-KDK----------------- BRDT_Hsap VLSQV----------------PFRKLNKK--------KE-KSK----------------- Y119C1B.8_Cele KLKAE----------------LAAA--------QAI-KDKLTS----------------- DDB0220693_Ddis KFKKD----------------DSNSINNNN------------------------------ DDB0220694_Ddis ---ST----------------PTS-EKKRK------------------------------ BRD_Spur ALSSQ----------------AHRKKKKK--------DK-DKT----------------- F13C5.2_Cele ------------------------------------------------------------ F57C7.1b_Cele TIAMQ----------------RR-EAKLAGNTAPALAQNQLSQLEGLGISIKSTPMMIPE AqueK041_Aque ALSKKGGGGGTPTLGIDANFAPFLSPAPS--------KE-KKK----------------- BRDT_Mmus -------------RAP--KRKKVN------------------N----------------- BRD4_Mmus -------------KEK--KK---E--------K-HK------K----------------- BRD3_Mmus -------------KEK--KKKDKDKDKE----K-EK------H----------------- BRD2_Mmus -------------KKK--KRKA-E--------K-HR------G----------------- BRD2_Hsap -------------KKK--KRKA-E--------K-HR------G----------------- BRD3_Hsap -------------KEK--KKKDKEK--E----K-EK------H----------------- BRD4_Hsap -------------KEK--KK---E--------K-HK------R----------------- BRDT_Hsap -------------KEK--KKEKVN------------------N----------------- Y119C1B.8_Cele -------------VKN--RRED-NPNEPFPEK------LI-------------------- DDB0220693_Ddis --------NNNNNYNN--NNNN-NNNNS----SSSSS-RS-------------------- DDB0220694_Ddis ---------HDEHVKV--KEDT-NSAQPTSSSSNHTN-GE-------------------- BRD_Spur -------------KKK--ERKDIEKEKE----ELEKAKELERQREKEMEEMREKERKLLE F13C5.2_Cele ------------------KEDN-AEEKPAEEP---------------------------- F57C7.1b_Cele LISPALSVRSSSRAPVPKIIDD-IGPSPIKAR------KI-------------------- AqueK041_Aque -------------KKD--KSSRKGKNKP-----VPS------------------------ BRDT_Mmus -RDE---N-------PRKK----P--KQMKQKEKA--K-------------------IN- BRD4_Mmus -KEEVEEN----KKSKTKEL---P----PKKTKKNNSSNSN--------------VSKK- BRD3_Mmus -KAKSEEE----KKAKAAPA---A--KQAQ-QKKAPTKKANST-----------TTASR- BRD2_Mmus -RIGIDED----DKGPRAPR---P--PQPKKSKKAGGGGSNATTLSHPGFGTSGGSSNK- BRD2_Hsap -RAGADED----DKGPRAPR---P--PQPKKSKKASGSGGGSAALGPSGFGPSGGSGTK- BRD3_Hsap -KVKAEEE----KKAKVAPP---A--KQAQ-QKKAPAKKANST-----------TTAGR- BRD4_Hsap -KEEVEEN----KKSKAKEP---P----PKKTKKNNSSNSN--------------VSKK- BRDT_Hsap -SNE---N-------PRKM----C--EQMRLKEKS--K-------------------RN- Y119C1B.8_Cele --------NETRA--L--CTT---------QVGQNAS-SSS-------------ASSAAL DDB0220693_Ddis -----SS-RKSHSSGS--SSSHR--SGSSRS-SRGS--SSS--------------SS--- DDB0220694_Ddis -----NA-SSSS----------S--SSSSKQSNNNNN-NNN--------------NN--- BRD_Spur EKARDEERSKSASKRPRKPAKSTEDKAKPKKTNRPRK-NAK-------------TAEEKP F13C5.2_Cele ----------------------------------------E-------------QPDEKE F57C7.1b_Cele --------SKPRA--S--MASNV--SVPY-------T-PTG-------------NPRGRK AqueK041_Aque ------------TSTPLLPT------LQPKKSKSA------------------------- BRDT_Mmus QP----------KKK-------KPLLKSEEEDN--------------AKPMNYDE-KRQL BRD4_Mmus EPV--------PTKTK-----PPPTYESEEEDK--------------CKPMSYEE-KRQL BRD3_Mmus QLK--------KGGKQ-----ASASYDSEEEEE--------------GLPMSYDE-KRQL BRD2_Mmus LPK--------KSQKT-APPVLPTGYDSEEEEE--------------SRPMSYDE-KRQL BRD2_Hsap LPK--------KATKT-APPALPTGYDSEEEEE--------------SRPMSYDE-KRQL BRD3_Hsap QLK--------KGGKQ-----ASASYDSEEEEE--------------GLPMSYDE-KRQL BRD4_Hsap EPA--------PMKSK-----PPPTYESEEEDK--------------CKPMSYEE-KRQL BRDT_Hsap QP----------KKRK-Q---QFIGLKSEDEDN--------------AKPMNYDE-KRQL Y119C1B.8_Cele RNG--------RSKKAASARLYGYEFDSDDEDN--------------KMALTYEE-KRNL DDB0220693_Ddis --S--------SSSSSS-SSSSSSSSSSSNNKK--------------YPKVTTEE-KTKL DDB0220694_Ddis --N--------SN---S-TTNSSS-SSSSTTTT--------------QKKYSDEE-RRSL BRD_Spur KPKRTNSRRGGGRKKK-V--PTTGQLESDDEDT--------------AKPMSYDE-KRQL F13C5.2_Cele -EE--------DH--ED-EREEQEEEDSSDEEDGL----------------DDDDVRR-- F57C7.1b_Cele -PK--------KSGRPK-KNIYSPATVSERISQQPPFEVTPYVSIYGRKVVGTND-KIEL AqueK041_Aque -------------KKR-T--PLNW-QPSSDEED--------------VKPMTYDE-KRQL *. :: : BRDT_Mmus SLDINKLPGDKLGRIVHIIQSREPSL-----RNSNPDEIEIDFETLKASTLRELEKYVLA BRD4_Mmus SLDINKLPGEKLGRVVHIIQSREPSL-----KNSNPDEIEIDFETLKPSTLRELERYVTS BRD3_Mmus SLDINRLPGEKLGRVVHIIQSREPSL-----RDSNPDEIEIDFETLKPTTLRELERYVKS BRD2_Mmus SLDINKLPGEKLGRVVHIIQAREPSL-----RDSNPEEIEIDFETLKPSTLRELERYVLS BRD2_Hsap SLDINKLPGEKLGRVVHIIQAREPSL-----RDSNPEEIEIDFETLKPSTLRELERYVLS BRD3_Hsap SLDINRLPGEKLGRVVHIIQSREPSL-----RDSNPDEIEIDFETLKPTTLRELERYVKS BRD4_Hsap SLDINKLPGEKLGRVVHIIQSREPSL-----KNSNPDEIEIDFETLKPSTLRELERYVTS BRDT_Hsap SLNINKLPGDKLGRVVHIIQSREPSL-----SNSNPDEIEIDFETLKASTLRELEKYVSA Y119C1B.8_Cele SNLINNLPNNQLNTIISIIQRRERSA--LMQQQLDDSEVELDFESLGDMCLREMGAFIKT DDB0220693_Ddis GAEITQLPVDLLPSILQIIHNTN-S----LPEQKPGSEVVIDLMKFDDDILRRLSKFVEQ DDB0220694_Ddis MERINELAPDDVQEVLNIIDP---N----AIKQA-DESLEIDMYQIDDKNLSQVESFINE BRD_Spur SLDINKLPGDKLGKVVHIIQSREPSL-----KDSTPDEIEIDFETLKPSTLRELEKYVMQ F13C5.2_Cele ------------------------------------------------------------ F57C7.1b_Cele SERMASIPQMYITPILRIIQIGHHNTGKTITSLRSLCEEEIDFNDVSDDLVIELLDYLEM AqueK041_Aque SLDINKLPGVTLNRVVHIIQMRERTI-----KDGNPDEIEIDFETLKPATLRELEKYVNS BRDT_Mmus CLRKR----SLKPQAK--K--V--------------------------VRSKEELHSEKK BRD4_Mmus CLRKK----R-KPQAEK--VDVIAGSSKMKGFSSSESESTSESSSSDSEDSETEMAPKSK BRD3_Mmus CLQKK----QRKPLSTSGKKQA--------------------------AKSKEELAQEKK BRD2_Mmus CLRKK----PRKPYTI--RKPV--------------------------GKTKEELALEKK BRD2_Hsap CLRKK----PRKPYTI--KKPV--------------------------GKTKEELALEKK BRD3_Hsap CLQKK----QRKPFSASGKKQA--------------------------AKSKEELAQEKK BRD4_Hsap CLRKK----R-KPQAEK--VDVIAGSSKMKGFSSSESESSSESSSSDSEDSETEMAPKSK BRDT_Hsap CLRKR----PLKPPAK--K--I--------------------------MMSKEELHSQKK Y119C1B.8_Cele IPTLNGNGDDEKPKTS--SNPTSSGA----------------------TGSKGSSSLESK DDB0220693_Ddis YKNGEI-PQHALPLSA----PSSTHS----------------------SHSSSHDSSSNI DDB0220694_Ddis CFKK-------------------------------------------------------- BRD_Spur CLRKR-----PKAYNK--GQ----------------------------TKSKQDAQKEKQ F13C5.2_Cele ----------HIPA-------------------------------------------STS F57C7.1b_Cele IQKDK-----AKAE-------------------------------------------QVR AqueK041_Aque VLKKQ-----KRPPTN--KS---------------------------------MDAAKKR BRDT_Mmus LEL-ERRLL---DVN-NQLN----CRK-----RQT-KRPAKVEKPPPPPPPPPPPPPPPE BRD4_Mmus KKGHTGRDQ---KKH-H-HHHHPQMQP-----APA-PV--PQQPP--------------- BRD3_Mmus KEL-EKRLQ---DVS-GQLN----S-K-----KPT-KK--E--KS--------------- BRD2_Mmus REL-EKRLQ---DVS-GQLN----STK-----KPP-KK--ASEKT--------------- BRD2_Hsap REL-EKRLQ---DVS-GQLN----STK-----KPP-KK--ANEKT--------------- BRD3_Hsap KEL-EKRLQ---DVS-GQLS----SSK-----KPA-RK--E--KP--------------- BRD4_Hsap KKGHPGREQ---KKH-H-HHHHQQMQQ-----APA-PV--PQQPP--------------- BRDT_Hsap QEL-EKRLL---DVN-NQLN----SRK-----RQT-KS----DKT--------------- Y119C1B.8_Cele NGK-K---KK-------------------------------------------------- DDB0220693_Ddis REI-EKLQKQLDRLGKGQQN----SSSSSSSSSHSKRI--SKPIS--------------- DDB0220694_Ddis ------------------------------------------------------------ BRD_Spur KEL-EDRLK---ELG-GPFP------K-----KAT-KK----AQQ--------------- F13C5.2_Cele APV-AKH--------------------------PEA------------------------ F57C7.1b_Cele QEL-EVKAKFYG----FEAY----DNKL-GTIPKTR------------------------ AqueK041_Aque AEL-EKRLQ---DVS-GKLG----GGSG--MPKLP-KT--KKSKS--------------- BRDT_Mmus LASGSRLTDSSSSS---------------------------------------------- BRD4_Mmus ------------------------------------------------------------ BRD3_Mmus ------------------------------------------------------------ BRD2_Mmus ------------------------------------------------------------ BRD2_Hsap ------------------------------------------------------------ BRD3_Hsap ------------------------------------------------------------ BRD4_Hsap ------------------------------------------------------------ BRDT_Hsap --------QPSKAV---------------------------------------------- Y119C1B.8_Cele ------------------------------------------------------------ DDB0220693_Ddis --------KARGRKVISTSSSNLNNSSNNINNNNNNINNYNNNNNYNNNNNNNLNNNNNN DDB0220694_Ddis ------------------------------------------------------------ BRD_Spur --------DALMNE---------------------------------------------- F13C5.2_Cele ------------------------------------------------------------ F57C7.1b_Cele ------------------------------------------------------------ AqueK041_Aque --------DAKGSK---------------------------------------------- BRDT_Mmus -----------------------------------GSGSG--SSSSS-SGSSSSSSSS-- BRD4_Mmus ------------------------------------------------------------ BRD3_Mmus ------------------------------------------------------------ BRD2_Mmus ------------------------------------------------------------ BRD2_Hsap ------------------------------------------------------------ BRD3_Hsap ------------------------------------------------------------ BRD4_Hsap ------------------------------------------------------------ BRDT_Hsap -----------------------------------ENV----SRLSE-S-SSSSSSSS-- Y119C1B.8_Cele --------------------------------------NFNMSESSDDE-TSNSRKRRKR DDB0220693_Ddis NINSNLNNNLNNNNNKDDIVIDGFKKENFSSIPEKDV-ETDISESS----DSESDSES-- DDB0220694_Ddis ------------------------------------------------------------ BRD_Spur -----------------------------------GG-RT--ERPLS-A-SSSSDSES-- F13C5.2_Cele ------------------------------AMPE-------------------------- F57C7.1b_Cele ------------------------------NMPP-PL-QHRMRSDS----PSPSASRT-- AqueK041_Aque -----------------------------------DL-KS--SRLSD-S-SSSSDDDSAN BRDT_Mmus GSASSS-SDSSSSDSSDSEPEIFPKFTGVK-Q---N------------------------ BRD4_Mmus ------------------------PPPQ-------------------------------- BRD3_Mmus ------------------------------------------------------------ BRD2_Mmus ------------------------------------------------------------ BRD2_Hsap ------------------------------------------------------------ BRD3_Hsap ------------------------------------------------------------ BRD4_Hsap ------------------------PPPQ-------------------------------- BRDT_Hsap ESESSS-SDLSSSDSSDSESEMFPKFTEVK-P---N------------------------ Y119C1B.8_Cele ESSES-QSSSSSDDDSDDED--RPSIPR-------------------------------- DDB0220693_Ddis GSSDS-SSSYSDSDFSDSDNDRRRNYNNSY-NNNNNNNNNNNSSNNFNNQNNSYNNSNNN DDB0220694_Ddis ------------------------------------------------------------ BRD_Spur DASSST-SASSSSDNSESESGT-PKKMKKGIKVP-PLP---------------------- F13C5.2_Cele ------------------------------------------------------------ F57C7.1b_Cele GNQSS-DSDSASDDSSDDEPS--RSNS--------------------------------- AqueK041_Aque EEESSSGTGSSTSSSSDEEKDVKPVQKART-----P------------------------ BRDT_Mmus -------------------------------------------------DLPPKENIKQ- BRD4_Mmus -------------------------------------------------QPPPPPPPQQQ BRD3_Mmus ------------------------------------------------------------ BRD2_Mmus ------------------------------------------------------------ BRD2_Hsap ------------------------------------------------------------ BRD3_Hsap ------------------------------------------------------------ BRD4_Hsap -------------------------------------------------QPPPPPPPQQ- BRDT_Hsap -------------------------------------------------DSPSKENVKKM Y119C1B.8_Cele ------------------------------------------------------------ DDB0220693_Ddis NNNNSSNNNNNNNNNNSNNNNSNNNNNNVNNN---------------------------- DDB0220694_Ddis ------------------------------------------------------------ BRD_Spur -------------------------------ANRQEMQRRLSGPGQAPITTPAGFHPETQ F13C5.2_Cele ------------------------------------------------------------ F57C7.1b_Cele ------------------------------------------------------------ AqueK041_Aque ------------------------------------------------------------ BRDT_Mmus ------------------------------------------------------------ BRD4_Mmus QQQPPPPPPPPSMPQQTAPAMKSSPPPFITAQVPVLEPQLPGSVFDPIGHFT-QPILHLP BRD3_Mmus ------------------------------------------------------------ BRD2_Mmus ------------------------------------------------------------ BRD2_Hsap ------------------------------------------------------------ BRD3_Hsap ------------------------------------------------------------ BRD4_Hsap QQQPPPPPPPPSMPQQAAPAMKSSPPPFIATQVPVLEPQLPGSVFDPIGHFT-QPILHLP BRDT_Hsap KNECIPPEGRTGV-T--------------------------------------------- Y119C1B.8_Cele ------------------------------------------------------------ DDB0220693_Ddis ------------------------------------------------------------ DDB0220694_Ddis ------------------------------------------------------------ BRD_Spur QQQPMSTGPGPS-PFS-------------------LGPQA---TGHPSGHPSGQPVQHPG F13C5.2_Cele ------------------------------------------------------------ F57C7.1b_Cele ------------------------------------------------------------ AqueK041_Aque ------------------------------------------------------------ BRDT_Mmus ---------------------------IQSSVQ-----------DITSAEAP-------- BRD4_Mmus QPELPPHLPQPPEHSTPPHLNQHAVVSPPA---LHNALPQQPSRPSNRAAALPPKPTRPP BRD3_Mmus ------------------------------------------------------------ BRD2_Mmus ------------------------------------------------------------ BRD2_Hsap ------------------------------------------------------------ BRD3_Hsap ------------------------------------------------------------ BRD4_Hsap QPELPPHLPQPPEHSTPPHLNQHAVVSPPA---LHNALPQQPSRPSNRAAALPPKPARPP BRDT_Hsap --------------------------QIGYCVQ-----------DTTSANTT-------- Y119C1B.8_Cele ----------------------------------KSGQPPSTSR---------------- DDB0220693_Ddis ----------NNNHNNNNHNNN--INNNNNNINNNTTQPSPSQQ----ST---------- DDB0220694_Ddis ------------------------------------------------------------ BRD_Spur QPS--PRLTNGQNHIPAP---------------RHSSLPALPDRPSNKAAPLQKRSQRKV F13C5.2_Cele ------------------------------------------------------------ F57C7.1b_Cele -----------------------------------NVAG--------------------- AqueK041_Aque ---------------------------------QATSKPIAPAYQTTSAASIIGRSQSK- BRDT_Mmus ------------------------------------------------------------ BRD4_Mmus --------------------------AVSPALAQP-PLLPQPPMAQPPQVLLEDEEPPAP BRD3_Mmus ------------------------------------------------------------ BRD2_Mmus ------------------------------------------------------------ BRD2_Hsap ------------------------------------------------------------ BRD3_Hsap ------------------------------------------------------------ BRD4_Hsap --------------------------AVSPALTQT-PLLPQPPMAQPPQVLLEDEEPPAP BRDT_Hsap ------------------------------------------------------------ Y119C1B.8_Cele ------------------------------------------------------------ DDB0220693_Ddis ------------------------------------------------------------ DDB0220694_Ddis ------------------------------------------------------------ BRD_Spur LTSPLTSPGPLTSPANTRGSTTTAFPLPSPTLPQTKPAVVAPPQLQPPAVS---KAPPAT F13C5.2_Cele ------------------------------------------------------------ F57C7.1b_Cele ------------------------------------------------------------ AqueK041_Aque ------------------------------------------------------------ BRDT_Mmus -------------------------------LAQQSTA-PCGAPG--------------- BRD4_Mmus PLT-----SMQMQLYLQQLQKVQPPTPLLPSVKVQSQPPPPLPPPPHPSVQQQQLQPQPP BRD3_Mmus ------------------------------------------------------------ BRD2_Mmus ------------------------------------------------------------ BRD2_Hsap ------------------------------------------------------------ BRD3_Hsap ------------------------------------------------------------ BRD4_Hsap PLT-----SMQMQLYLQQLQKVQPPTPLLPSVKVQSQPPPPLPPPPHPSVQQ-QLQQQPP BRDT_Hsap -------------------------------LVHQTTP-SHVMPP--------------- Y119C1B.8_Cele ------------------------------------------------------------ DDB0220693_Ddis ------------------------------------------------------------ DDB0220694_Ddis ------------------------------------------------------------ BRD_Spur PPAMAPSAPVAPQPAPVAIPKPKPEPVVKPSKPAPSQTPPAAVPPP--SSTK-------- F13C5.2_Cele ------------------------------------------------------------ F57C7.1b_Cele ------------------------------------------------------------ AqueK041_Aque ------------------------------------------------------------ BRDT_Mmus -----------------------------------------------------K------ BRD4_Mmus PPPPPQPQPPPQQQHQPPPRPVHLPSMPFSAHIQ--QPPPPP-GQQPTHPPPGQQPPPPQ BRD3_Mmus ------------------------------------------------------------ BRD2_Mmus ------------------------------------------------------------ BRD2_Hsap ------------------------------------------------------------ BRD3_Hsap ------------------------------------------------------------ BRD4_Hsap PPPPPQPQPPPQQQHQPPPRPVHLQPMQFSTHIQ--QPPPPQ-GQQPPHPPPGQQPPPPQ BRDT_Hsap -----------------------------------------------------N------ Y119C1B.8_Cele ------------------------------EWNQSSAPPPRM-GGMGG------------ DDB0220693_Ddis ------------------------------SLTNEPIKPPTILQTVKK--PAL--PVTG- DDB0220694_Ddis ------------------------------------------------------------ BRD_Spur ----PLPQHPPPQQHPSRHSPQPLPQQQATSKPQSKPPPPTD--IPKPQPPAAQRPIPAD F13C5.2_Cele ------------------------------------------------------------ F57C7.1b_Cele ------------------------------------------------------------ AqueK041_Aque ------------------------------------------------------------ BRDT_Mmus ------------------------------------------------------------ BRD4_Mmus PAK-----PQQVIQHHPSPR-------------------------------------HHK BRD3_Mmus ------------------------------------------------------------ BRD2_Mmus ------------------------------------------------------------ BRD2_Hsap ------------------------------------------------------------ BRD3_Hsap ------------------------------------------------------------ BRD4_Hsap PAK-----PQQVIQHHHSPR-------------------------------------HHK BRDT_Hsap ------------------------------------------------------------ Y119C1B.8_Cele -----------QP----------------------------------------------- DDB0220693_Ddis ----------SVASWSFD------------------------------------------ DDB0220694_Ddis ------------------------------------------------------------ BRD_Spur --TKKTAPPRSVTPPSPPPQVKPEVPSLIQQPTLIPKVEDNPMSFMVGDEDLEGEGESPS F13C5.2_Cele ------------------------------------------------------------ F57C7.1b_Cele ------------------------------------------------------------ AqueK041_Aque ------------------------------------------------------------ BRDT_Mmus ------------------------------HSQQMLGCQVTQHLQAT-E----------- BRD4_Mmus SDPYSAGHLREAPSP------------LMIHSPQMPQFQSLTHQSPPQQNVQPKKQVKGR BRD3_Mmus ------------------------------------------------------------ BRD2_Mmus ------------------------------------------------------------ BRD2_Hsap ------------------------------------------------------------ BRD3_Hsap ------------------------------------------------------------ BRD4_Hsap SDPYSTGHLREAPSP------------LMIHSPQMSQFQSLTHQSPPQQNVQPKK----- BRDT_Hsap ------------------------------HHQLAFNYQELEHLQTV-K----------- Y119C1B.8_Cele ------------------------------------------------------------ DDB0220693_Ddis ------------------------------------------------------------ DDB0220694_Ddis ------------------------------------------------------------ BRD_Spur TSPVMTGHKTEESNGSSHPEGGMPSSASSENLSKMEQKASSKDKKPPAVSKAPPATP--- F13C5.2_Cele ------------------------------------------------------------ F57C7.1b_Cele ------------------------------------------------------------ AqueK041_Aque ------------------------------------------------------------ BRDT_Mmus --------------------------------NTA------------------------- BRD4_Mmus AEPQPPGPVMGQGQGCPPASPAAVPMLSQELRPPSVVQPQPLVVVKEEKIHSPIIRSEPF BRD3_Mmus ------------------------------------------------------------ BRD2_Mmus ------------------------------------------------------------ BRD2_Hsap ------------------------------------------------------------ BRD3_Hsap ------------------------------------------------------------ BRD4_Hsap ----------------------------QELRAASVVQPQPLVVVKEEKIHSPIIRSEPF BRDT_Hsap --------------------------------NIS------------------------- Y119C1B.8_Cele ------------------------------------------------------------ DDB0220693_Ddis ------------------------------------------------------------ DDB0220694_Ddis ------------------------------------------------------------ BRD_Spur ----------------------------PAMAPSAPVAPQPAPVAIPKPKPEPVVKPSKP F13C5.2_Cele ------------------------------------------------------------ F57C7.1b_Cele ------------------------------------------------------------ AqueK041_Aque ------------------------------------------------------------ BRDT_Mmus ---------------------------------------SVQTQPLSG------------ BRD4_Mmus STSLR-----------------PEPPKHPENIKAPVHLP--------------------- BRD3_Mmus ------------------------------------------------------------ BRD2_Mmus ------------------------------------------------------------ BRD2_Hsap ------------------------------------------------------------ BRD3_Hsap ------------------------------------------------------------ BRD4_Hsap SPSLR-----------------PEPPKHPESIKAPVHLP--------------------- BRDT_Hsap ---------------------------------------PLQILPPSG------------ Y119C1B.8_Cele ---------------------------------------PMSRVPASS------------ DDB0220693_Ddis ---------------------------------------PTNNKESSS------------ DDB0220694_Ddis ------------------------------------------------------------ BRD_Spur APSQTPPAAVPPPSSTKPLPQHPPPQQHP-SRHSPQPLPQQQATSKPQSKPPPPTDIPKP F13C5.2_Cele ------------------------------------------------------------ F57C7.1b_Cele ---------------------------------------PRRALELSG------------ AqueK041_Aque --------------------------------------SSLTTVPAGGAVAPPPTK---- BRDT_Mmus -----------DCK---------------------------------------------- BRD4_Mmus --------QRPEMK---------------------------------------------- BRD3_Mmus ------------------------------------------------------------ BRD2_Mmus ------------------------------------------------------------ BRD2_Hsap ------------------------------------------------------------ BRD3_Hsap ------------------------------------------------------------ BRD4_Hsap --------QRPEMK---------------------------------------------- BRDT_Hsap -----------DSE---------------------------------------------- Y119C1B.8_Cele -----------STSVS-------------------------------------------- DDB0220693_Ddis -----------SSSTS-------------------------------------------- DDB0220694_Ddis ------------------------------------------------------------ BRD_Spur QPPAAQRPIPADTKKTAPPRSVTPPSPPPQVKPEVPSLIQQPTLIPKVEDNPMSFMVGDE F13C5.2_Cele ------------------------------------------------------------ F57C7.1b_Cele -----------NSSSA-------------------------------------------- AqueK041_Aque --------------------DAAPPSP--------------------------------- BRDT_Mmus ------------RVLLGPPVVHT------------SA-E-SLTVLE-------------- BRD4_Mmus ------------PVDIGRPVIRPPEQSAPPPGA----PDKDKQKQE-------------- BRD3_Mmus --------------------------GSAPSGG----PSRL------------------- BRD2_Mmus ------------------------ES-SAQQVA----VSRL------------------- BRD2_Hsap ------------------------ESSSAQQVA----VSRL------------------- BRD3_Hsap --------------------------GSAPSGG----PSRL------------------- BRD4_Hsap ------------PVDVGRPVIRPPEQNAPPPGA----PDKDKQKQE-------------- BRDT_Hsap ------------QLSNGITVMHP------------SG-DSDTTMLE-------------- Y119C1B.8_Cele --------------AIGK---------------NNAA--ASSNSYR-------------- DDB0220693_Ddis ---------------------------------STSS--TSNTTLTPIIQQSSLTHASSP DDB0220694_Ddis ------------------------------------------------------------ BRD_Spur DLEGEGESPSTSPVMTGHKTEESNGSSHPEGGMPSSASSENLSKME-------------- F13C5.2_Cele ------------------------------------------------------------ F57C7.1b_Cele ---------------------------------STPA--GPSK-AQ-------------- AqueK041_Aque -------------------------------GF-----------QE-------------- BRDT_Mmus ----------PECHAPAQKDIKIKN--ADSWKSLGK--P--VKAS--SVLKSSDELFNQF BRD4_Mmus ----------PKTPVAPKKDLKIKN--MGSWASLVQKHP--TTPS--STAKSSSDSFEHF BRD3_Mmus ----------------------------SSSS----SSE--SASS--SSSGSSSDS---- BRD2_Mmus ----------------------------SASS---SSSD--SSSS--SSSSSSSDT---- BRD2_Hsap ----------------------------SASS---SSSD--SSSS--SSSSSSSDT---- BRD3_Hsap ----------------------------SSSS----SSE--SGSS--SSSGSSSDS---- BRD4_Hsap ----------PKTPVAPKKDLKIKN--MGSWASLVQKHP--TTPS--STAKSSSDSFEQF BRDT_Hsap ----------SECQAPVQKDIKIKN--ADSWKSLGK--P--VKPS--GVMKSSDELFNQF Y119C1B.8_Cele ----------YRCFFVRKLNLKISN--KKKWKSKKN--S--TNLVFRSSKTCTSTSTNII DDB0220693_Ddis ISSSTFVSFSSSSSTPPTNNLSPPSPGLPNSPSINS--P--SSPS--ANNNNTDSAWNHF DDB0220694_Ddis ------------------------------------------------------------ BRD_Spur ----------QKASSKDKKDMKLPN--RYSWSNLANT-PSSTKPS-SKPTKTSHHSFELF F13C5.2_Cele -------------------------P---------------------------------- F57C7.1b_Cele -------------------------P---------------------------------- AqueK041_Aque ----------PIE---------------------M----GGVK-K-R-AIPSADSSFAQF BRDT_Mmus RKAAIEKEVKART----QEQMRKHLEHNAK--DPKVSQENQ--REPGSGLTLESLSSKVQ BRD4_Mmus RRAAREKEEREKALK-AQAE---HAEKE--KERLRQERMRS--REDEDALEQARRAHEEA BRD3_Mmus ------------------------------------------------------------ BRD2_Mmus ------------------------------------------------------------ BRD2_Hsap ------------------------------------------------------------ BRD3_Hsap ------------------------------------------------------------ BRD4_Hsap RRAAREKEEREKALK-AQAE---HAEKE--KERLRQERMRS--REDEDALEQARRAHEEA BRDT_Hsap RKAAIEKEVKART----QELIRKHLEQNTK--ELKASQENQ--RDLGNGLTVESFSNKIQ Y119C1B.8_Cele -KTSGSTE---TTVK-TKENGRNQQR------RLRLDHQRK--ANPG---------MVKT DDB0220693_Ddis KAKNITLKQKEKERVLQEEVLRKEREEKEE--ELKKEEEKK--RI-----------EMEE DDB0220694_Ddis ------------------------------------------------------------ BRD_Spur KKAAKEKEERTRQIK-QQEEMRKQQKHLQEQERARQERERQ--RE-----------KEED F13C5.2_Cele ------------------------------------------------------------ F57C7.1b_Cele ------------------------------------------------------------ AqueK041_Aque KKQALENAEREKANK-QQEDLRKQQIMLMQQNKKETESKSNTASP-----------VGGG BRDT_Mmus DKSLEEDQSEQQPPSEA-QD------------------VSKLWLLKDRNLAREKEQERRR BRD4_Mmus RRRQEQQQQQQQQRQEQQQQQQQAAAVAAASAPQAQSSQPQSMLDQQRELARKREQERRR BRD3_Mmus ------------------------------------------------------------ BRD2_Mmus ------------------------------------------------------------ BRD2_Hsap ------------------------------------------------------------ BRD3_Hsap ------------------------------------------------------------ BRD4_Hsap RRRQEQQQQQRQ--EQQQQQQQQAAAVAAAATPQAQSSQPQSMLDQQRELARKREQERRR BRDT_Hsap NKCSGEEQKEHQQSSEA-QD------------------KSKLWLLKDRDLARQKEQERRR Y119C1B.8_Cele SRPGFRGCGWR-QS-EPA---------------------------------------K-- DDB0220693_Ddis IKRLAKEKEER-EA-EET----------------------RKQIESERAAAREA-REKEK DDB0220694_Ddis ------------------------------------------------------------ BRD_Spur -DALERARNSQ-QE-EAK----------------------RTQSMKER--ERLREQERRK F13C5.2_Cele ----------------------------------------AAEHSSIQSSE-AQALG--E F57C7.1b_Cele ----------------------------------------AVVRPSSKSVASKPAYTKRT AqueK041_Aque -------GGAD-SG-GMN----------------------SPVDEVER--ERLKEKQRQE BRDT_Mmus REAM----AGTIDMTLQSD--IM------------------------------------- BRD4_Mmus REAM----AATIDMNFQSD--LL------------------------------------- BRD3_Mmus ------------------------------------------------------------ BRD2_Mmus ------------------------------------------------------------ BRD2_Hsap ------------------------------------------------------------ BRD3_Hsap ------------------------------------------------------------ BRD4_Hsap REAM----AATIDMNFQSD--LL------------------------------------- BRDT_Hsap REAM----VGTIDMTLQSD--IM------------------------------------- Y119C1B.8_Cele ---------------KKTK--AV------------------------------------- DDB0220693_Ddis LNNS----KGNMSFQYQMD--VM------------------------------------- DDB0220694_Ddis ------------------------------------------------------------ BRD_Spur REAY----HEMLSWGFEDSSQIISTLLVYLDLCEGKNWWHMEIHPCWPLHMAYITGRAFK F13C5.2_Cele ISGAHPIHIGESEIAGHAA--DS------------------------------------- F57C7.1b_Cele LSES----SSSSDSNGSSS--DS------------------------------------- AqueK041_Aque REKM----KQQIDMTYQND--LM------------------------------------- BRDT_Mmus ---------------------TM------------------------------------- BRD4_Mmus ---------------------SIF------------------------------------ BRD3_Mmus -----------------------S------------------------------------ BRD2_Mmus -----------------------S------------------------------------ BRD2_Hsap -----------------------S------------------------------------ BRD3_Hsap -----------------------S------------------------------------ BRD4_Hsap ---------------------SIF------------------------------------ BRDT_Hsap ---------------------TM------------------------------------- Y119C1B.8_Cele ---------------------SRC------------------------------------ DDB0220693_Ddis ---------------------ASFEDNIDSSGSLLNL----------------------- DDB0220694_Ddis ------------------------------------------------------------ BRD_Spur KDDITAVLPLQAKATLSPSSLRTFLTTLDPEHSSLQSSFKTPSKAVIPEEHRAKRAITLA F13C5.2_Cele ----------------------TT------------------------------------ F57C7.1b_Cele ---------------------SDS------------------------------------ AqueK041_Aque ---------------------SQ------------------------------------- BRDT_Mmus --------------------------------------FENNFD BRD4_Mmus ---------------------------------------EENLF BRD3_Mmus -----------------------------------------DSE BRD2_Mmus ---------------------------------------DSDSG BRD2_Hsap ---------------------------------------DSDSG BRD3_Hsap -----------------------------------------DSE BRD4_Hsap ---------------------------------------EENLF BRDT_Hsap --------------------------------------FENNFD Y119C1B.8_Cele ---------------------------------------QTKWK DDB0220693_Ddis -----------------------------------QLKPIEDPL DDB0220694_Ddis ---------------------------------------QKQDE BRD_Spur ITDSDSTIVYYKISDGLVPPDSGPKIPTEDGSDDGGKEEGRASL F13C5.2_Cele ---------------------------------------GESHA F57C7.1b_Cele ---------------------------------------DSEPS AqueK041_Aque --------------------------------------FEMTMY