CLUSTAL W (1.83) multiple sequence alignment Bub1_Dmel MDF-------------------DNA--------KENIQPLASGRN-----VS-LLQAS-L CG14030_Dmel MAMHS---------------YM--------------RQGSGSGGG-----AG-AVAAG-- BUBR1_Mmus MAEASE-------AMCLEGAEWELS--------KENIQPLRHGRV-----MS-TLQGA-L BUB1_Mmus MDN-------------------L------------------------------------- R06C7.8_Cele MSHIRVAF--------------------------A---PLDTNPS-----TC-GLETF-A BUB1_Scer MNL-------------------DLGSTVRGYESDKDTFPQSKG----------------V BUB1_Hsap MDT-------------------P------------------------------------- BUBR1_Hsap MAAVKKEGGALSEAMSLEGDEWELS--------KENVQPLRQGRI-----MS-TLQGA-L Bub1_Ddis MSSLS---------------DWENT--------KENIVPLKTGRD-----PT-KLALF-- BUB1_Spur MERDQDMKS---------IDEWELS--------KENVLPLKQGRK-----MT-NLTAA-L CC1G_03571_Ccin MISADDVFQ-ESEPVVVDCDLLEAA--------KENVQPLATGRR-----VT-ALSTV-L CC1G_07078_Ccin MSSSTLS----------------------------------------------------- AqueK151_Aque MHQYTLTH--------------------------THTHTLILYTITMYLSLS-LLSHSCN BUB_a-2_Smoe ------------------------------------------------------------ BUB_b-2_Smoe MEW-------------------ELS--------KENVQPLRKGRK-----NVDLLNQG-L BUB_b-1_Smoe MEW-------------------ELS--------KENVQPLRKGRK-----NVDLLNQG-L BUB_a-1_Smoe ------------------------------------------------------------ Bub1_Dmel -S-QDSTH--GQELLAQRKQM----EEEV--RTYKGADPL-------------------- CG14030_Dmel -APPLASPDEMHGFLNDKQAW----EHAI--SLYQGPDPL-------------------- BUBR1_Mmus -AKQESAG--HTALQQQKRAF----ESEI--RFYSGDDPL-------------------- BUB1_Mmus --------------ENVFRMF----EAHM--QSYTGNDPL-------------------- R06C7.8_Cele --TQIETL--SQM--------------------------------------M-------- BUB1_Scer SSSQKE-Q--HSQLNQTKIAY----EQRLLNDLEDMDDPL-------------------- BUB1_Hsap --------------ENVLQML----EAHM--QSYKGNDPL-------------------- BUBR1_Hsap -A-QESAC--NNTLQQQKRAF----EYEI--RFYTGNDPL-------------------- Bub1_Ddis -AKQTNQS--DEELEKEKQKF----EIII--NEYQGEDPI-------------------- BUB1_Spur -QPQNFDR--QQQLILQRQGF----ETEL--RTYTGDDPL-------------------- CC1G_03571_Ccin -ATPAAQR--DAKLSATRNRLRINVELAL--E-DEDGDPL-------------------- CC1G_07078_Ccin ------AA--DRERYRE--KYRKKL----AKALTEDDDPL-------------------- AqueK151_Aque --TNFEFL--EKI-------YTSKL--ND--QDYFYQVPSKQLIMYPKHLVYPDGVDAKR BUB_a-2_Smoe ------------------------------------------------------------ BUB_b-2_Smoe KAKHKSPA--RSVLIEQRRIL----LEKI--DDYVGDDPL-------------------- BUB_b-1_Smoe KAKHESPA--RSVLIEQRRIL----LEKI--DDYVGDDPL-------------------- BUB_a-1_Smoe ------------------------------------------------------------ Bub1_Dmel ------------------------GAWYTFICWIEQSYPAGGS-GS---GLQ---TVLHQ CG14030_Dmel ------------------------DHWYNYICWYEN-HAQSDP-EL---KYR---ETLER BUBR1_Mmus ------------------------DVWDRYINWTEQNYPQGGK-ES---NMS---ALVER BUB1_Mmus ------------------------GEWESFIKWVEENFPDN---KE---YLM---TLLEH R06C7.8_Cele ------------------------------------------TAE----EMK---AELYD BUB1_Scer ------------------------DLFLDYMIWISTSYIEVDS-ESGQEVLR---STMER BUB1_Hsap ------------------------GEWERYIQWVEENFPEN---KE---YLI---TLLEH BUBR1_Hsap ------------------------DVWDRYISWTEQNYPQGGK-ES---NMS---TLLER Bub1_Ddis ------------------------DNWLKYIKWVQQSYPGGNM-KE---QLI---VLLER BUB1_Spur ------------------------DSWIRYIQWTEQNFPQGGK-DS---HLG---VLMQK CC1G_03571_Ccin ------------------------EAYCRLVYWTMENYPQGHSAES---GLL---ELLEE CC1G_07078_Ccin ------------------------ATYNQFVQWTVKHYGEKDR-SS---GLL---ELLKD AqueK151_Aque DVCLEELRASRTRYCPSPSPDCDMDMTEAYCGNITVNVPVVASME----KGREVLHLMEH BUB_a-2_Smoe -------------------------------------------------ELC---PLLEF BUB_b-2_Smoe ------------------------EPWIRCIEWTKEAFPSGGS-QS---GIL---PMLEL BUB_b-1_Smoe ------------------------EPWIRCIEWTKEAFPSGGS-QS---GIL---PMLEL BUB_a-1_Smoe -------------------------------------------------ELC---PLLEF : Bub1_Dmel CLTKFEDD------ERYRQDKR-LIKLFIKFMEK---------------------QKDKI CG14030_Dmel CLTVYEHN------DYYRQDVR-LVRLWLKYIAM---------------------QTDPL BUBR1_Mmus AIEALQGE------TRYYNDPR-FLSLWIKLGHL---------------------CNEPL BUB1_Mmus LMKEFLHK------KNYHNDSR-FINYCLKFAEY---------------------NSDRH R06C7.8_Cele CVRRILREQKF---DQIRENEA-MLRLYKVMGRS-------------------STNLKGR BUB1_Scer CLIYIQDM------ETYRNDPR-FLKIWIWYINLFL----------------SNNFHESE BUB1_Hsap LMKEFLDK------KKYHNDPR-FISYCLKFAEY---------------------NSDLH BUBR1_Hsap AVEALQGE------KRYYSDPR-FLNLWLKLGRL---------------------CNEPL Bub1_Ddis CTRLFLST------EKYKNDPR-YLRIWITYADM---------------------CRDPI BUB1_Spur CLIQFKND------DLYKQDIR-YVSIWLKMAQY---------------------DSESL CC1G_03571_Ccin ATRVLKDHNG----GVYRGDMK-YLKLWLIYASY---------------------VERPT CC1G_07078_Ccin ATNQFKDD------PMYKNDLR-YLKMWALYARQL-------------------ERSQAA AqueK151_Aque KPEKLLVLSKEEPGGNMTRELQEKENLPVSLNQF-------------------DFTPSAS BUB_a-2_Smoe CTKAFLDD------PRYREDLR-YLRIWLRYVSLLLCLVLLYSYFPSLQPLQADCCADPL BUB_b-2_Smoe CLRTFCDD------SKYKSDLR-YLKLWLDYADR---------------------CTHPR BUB_b-1_Smoe CLRTFCDD------SKYKSDLR-YLKLWLDYADR---------------------CTHPR BUB_a-1_Smoe CTKAFLDD------PRYREDLR-YLRIWLRYVSLLLCLVLLYSYFPSLQPLQADCCADPL : Bub1_Dmel EFYQQ--MYNNG-IGTMLADFYIAWAYS----YDLSGNMRKADEIFRLGLECRAEPLEDL CG14030_Dmel HFYQV--LFQRG-TGRQVAAFYIGWAAY----YESREEYKDAEAVFNLAFQEKAQSTSEL BUBR1_Mmus DMYSY--LQSQG-IGVSLAQFYISWAEE----YEARENFKKADIIFQEGIERKAEPLDRL BUB1_Mmus QFFEF--LYNQG-IGTKSSYIYMSWAGH----LEAQGELQHASAIFQTGIHNEAEPKELL R06C7.8_Cele GIYEQ--LFKKD-HFTGSLKFYLQWAEE----CGKDQMLEEFKDVLKLARDRLSERIEMT BUB1_Scer NTFKY--MFNKG-IGTKLSLFYEEFSKL----LENAQFFLEAKVLLELGAENNCRPYNRL BUB1_Hsap QFFEF--LYNHG-IGTLSSPLYIAWAGH----LEAQGELQHASAVLQRGIQNQAEPREFL BUBR1_Hsap DMYSY--LHNQG-IGVSLAQFYISWAEE----YEARENFRKADAIFQEGIQQKAEPLERL Bub1_Ddis EVFSF--LEVQR-IGFYLSLLYEARAIV----YENKGNYEQADKSFKQGIERKAQPIERL BUB1_Spur EIFKF--MQANQ-TGTKLTLFYEAWAWE----LEQVGNTKRADAIYKEGLANNAQPRERL CC1G_03571_Ccin IIYRF--LLAND-IGIGFALLYEEHAAV----LERDGRKQEADEIYALGIARKAEPLDHL CC1G_07078_Ccin KIYAF--LVEKE-IGTTYSALYEDYANL----LEREGRRSEAEKIYLQGIEKQVRPLERL AqueK151_Aque ESYSHQYSYNGASFSMKGALSFSESDSLVSSACQSEEEAKMFKEKTVLKQERHSDQVH-- BUB_a-2_Smoe HIFEL--LEAKR-IGQTHSLFYEAYAMI----LELRGDITKANQIYELGISRHAQPVEQL BUB_b-2_Smoe DIYVF--LEVND-IGQTYAQFYEAYASY----LERCKNLSKANEVFQIGIARAAEPVEEL BUB_b-1_Smoe DIYVF--LEVND-IGQTYAQFYEAYASY----LERCKNLSKANEVFQIGIAREAEPVEEL BUB_a-1_Smoe HIFEL--LEAKR-IGQTHSLFYEAYAMI----LELRGDITKANQIYELGISRHAQPVEQL : : . Bub1_Dmel KEAHHHFGYTVGQRMLYSTGE----EANAVN---------Q-ELNERRLALQ-SLHGRRQ CG14030_Dmel QHAHTKFAYARSLFYQRQQQQ---QQQ-QQ----------QHQQHPPQDALQ-QLTNYAQ BUBR1_Mmus QSQHRQFQSRVSRQAFLALGN---EE-EEA----------LEPSEPQRSSLA-ELKSRGK BUB1_Mmus QQQYRLFQARLTGIHLPAQAT----TSEPLH---------SAQILN-------------- R06C7.8_Cele -AIESGFRDLVD---EYFNGESGDMFTRPDETM-DLFRFNAGSKKKRRSSVC-FLQHN-- BUB1_Scer LRSLSNYEDRLREMNIVENQN-----SVPDS---------RERLKG-----------RLI BUB1_Hsap QQQYRLFQTRLTETHLPAQAR----TSEPLH---------NVQVLN-------------- BUBR1_Hsap QSQHRQFQARVSRQTLLALEK---EEEEEV----------FESSVPQRSTLA-ELKSKGK Bub1_Ddis QQKHLDFERRLIARLKHQQQH---QQL-QQ----------QQQQQNDQLEQQ-QLDENGN BUB1_Spur ERALIEFQSRVGRATVQQMQE---GTMNPTS---------TASAEDQRATLG-DLRARG- CC1G_03571_Ccin ESRYQDFQKRMISTFTAPAPE----PARTTQ-----------AAQPKRQALA-TTSKIPT CC1G_07078_Ccin KTRYKEFQARASQAAAQSN-R-----SIPSG--------------SRSASLA-SIASAPS AqueK151_Aque ----QSLQYTHSSESLYANNKLPCPKTKPVSQLSRTLETDIGTSSVPISSIAVSQEGRLD BUB_a-2_Smoe EKMHASFLKRKFKTSRPSE----------------------------------------- BUB_b-2_Smoe KIKYKSFLERTLRKPKPDA------EEDT------------------------------- BUB_b-1_Smoe KIKYKSFLERTLRKPKPDA------EEDT------------------------------- BUB_a-1_Smoe EKMHASFLKRKFKTSRPSE----------------------------------------- Bub1_Dmel -QISNSITVGSIRTGAAVK-------SGLPGVVQVEP----------STTTSRRNVGRNV CG14030_Dmel QQMPQ---SYN-----------------Q-----HRP----------QPYQQN------- BUBR1_Mmus -KMAR---APISRVGGALK--APGQ--S-RGFLNAVP----------QPVHGN----RRI BUB1_Mmus -----------------------------------------------QVMMTNSSPEKNS R06C7.8_Cele --------VPINNSGKAAF--GPKT--K-TDLRQ-------------------------- BUB1_Scer -YRTAPFFI-----------------------RKFLT----------SSLM--TDDKENR BUB1_Hsap -----------------------------------------------QMITSKSNPGNNM BUBR1_Hsap -KTAR---APIIRVGGALK--APSQ--N-RGLQNPFP----------QQMQNN----SRI Bub1_Ddis TKLTR---SALGTISSSSV--HSERKSQQTKGLPLGNSTIDKKRKVGNDQKNN----LGF BUB1_Spur -KHQK---VGTNRTGAAMR--S-----S-RGGLPTAP----------APLQQRS---NQI CC1G_03571_Ccin -STSR---TGGTRIASSSR--N-----T-TVAAPTNM----------PPPSNRG----GF CC1G_07078_Ccin -TTSA-NLVSFNST-AA----------S-RYALMLAP----------TPP---------- AqueK151_Aque -SF-----SVYNDSQVSINQPAAGQS-T-RPPLQVLP----------QE-KS-L---TSF BUB_a-2_Smoe ------------------------------------------------------------ BUB_b-2_Smoe ------------------------------------------------------------ BUB_b-1_Smoe ------------------------------------------------------------ BUB_a-1_Smoe ------------------------------------------------------------ Bub1_Dmel EVFNDENS-EGNIP----------------------ISNSE-TEV-KSSLRSIID-S--A CG14030_Dmel -VYQQYHP-QAQ-A-------------------HQAPQPHQP-----------A-----P BUBR1_Mmus TVFDENAD-TAS-R----------------------TELSK-PVAQ-PWMAPPV-----P BUB1_Mmus ACVPRS------QG----------------------SECS-----------GVAS-S--T R06C7.8_Cele -----ACI-DRP-NY--------------------------------------------- BUB1_Scer ANLNSN------VG----------------------VGKSA-P--------NVYQDSIVV BUB1_Hsap ACISKN------QG----------------------SELS-----------GVIS-S--A BUBR1_Hsap TVFDENAD-EAS-T----------------------AELSK-PTVQ-PWIAPPM-----P Bub1_Ddis QIFDDEKG-GST-TNEVLTDSKFFGSSRKAAALMAAGQTQQTSQMKWDELEPEL-----N BUB1_Spur SIFCDDGA-QG-------------------------AAAAQ-PSGQWQHLPSRS-----E CC1G_03571_Ccin QIFVDPSGQNG-------------------------EAREG-GENGWHDLGTRK-----T CC1G_07078_Ccin ------------------------------------------------------------ AqueK151_Aque SVYEEASI-NQP-SF----------------------KQSV-PSAR-P----P------- BUB_a-2_Smoe ------------------------------------------------------------ BUB_b-2_Smoe ------------------------------------------------------------ BUB_b-1_Smoe ------------------------------------------------------------ BUB_a-1_Smoe ------------------------------------------------------------ Bub1_Dmel CSQEN-IKEPVAWNKANAKRHK--HGKIFGSNASP--DLGFDIHVDEQ------------ CG14030_Dmel QQQLP-PEQQVPYQTHY--QER-PRYEPH----------P-------------------- BUBR1_Mmus RAKEN-ELQPGPWSTDRPAGRR-PHDNPASVTSIPSVLPSFTPYVEES------------ BUB1_Mmus CDEKSNIREQRVIMIS-------------------------------------------- R06C7.8_Cele ------------------------------------------------------------ BUB1_Scer ADFKSET-ERLNLNSS--KQPS--NQRLKNGNKK------TSIYADQK------------ BUB1_Hsap CDKESNM-ERRVITIS-------------------------------------------- BUBR1_Hsap RAKEN-ELQAGPWNTGRSLEHR-PRGNTASLIAVPAVLPSFTPYVEET------------ Bub1_Ddis KHKEN-TQLSQKWSDVKLLQKK-QKITTA----------GFQIYCDQDSLSNNNNGSNNN BUB1_Spur SQKEN-TSSAGQWAGQRLPQRNMPRMTFQEVSSY--SRPDFAVHVDEN------------ CC1G_03571_Ccin RVKEN-VPETKKLVGTTIKQAGKTR----------------------------------- CC1G_07078_Ccin ------------------------------------------------------------ AqueK151_Aque ------------------------------------------------------------ BUB_a-2_Smoe ------------------------------------------------------------ BUB_b-2_Smoe ------------------------------------------------------------ BUB_b-1_Smoe ------------------------------------------------------------ BUB_a-1_Smoe ------------------------------------------------------------ Bub1_Dmel ----------------------------------AMPPITNYE----------------- CG14030_Dmel -----ATQSPTAIPPSQVQQQSHYAPVAESHYAPAQQSQLPPQQTTVPQLHAQQPQQQQN BUBR1_Mmus ----------------------------------AQQTVMTPC----------------- BUB1_Mmus ------------------------------------------------------------ R06C7.8_Cele ------------------------------------------------------------ BUB1_Scer ------------------------------------------------------------ BUB1_Hsap ------------------------------------------------------------ BUBR1_Hsap ----------------------------------ARQPVMTPC----------------- Bub1_Ddis NNNNNNENIPL-SPDK---------LRV---HSSKQQSKLEQI----------------- BUB1_Spur ----------------------------------ADQ-ITTPR----------------- CC1G_03571_Ccin ------------------------------------------------------------ CC1G_07078_Ccin ------------------------------------------------------------ AqueK151_Aque ------------------------------------------------------------ BUB_a-2_Smoe ------------------------------------------------------------ BUB_b-2_Smoe ------------------------------------------------------------ BUB_b-1_Smoe ------------------------------------------------------------ BUB_a-1_Smoe ------------------------------------------------------------ Bub1_Dmel --------RRLEQP------FRFPTNFVAKNRPQE-PWVTPVTI-EDEPNASGLPCYNKC CG14030_Dmel GNGNPPPQQSPPVTNE-VAGLRLPRNFHAYGRNNHETWKPALTLEEPDDP-SRVCHYAKQ BUBR1_Mmus --------KIEPSINH-VLSTRKP-----GREEGDPLQRVQSHQQGCEEK-KEKMMYCKE BUB1_Mmus -------------------------------KSEC---SVSSS-VAPKPE-AQQVMYCKE R06C7.8_Cele ------------------------------------------------------------ BUB1_Scer -------------------------------QSNN---PVYKLINTPGRK-PERIVFNFN BUB1_Hsap -------------------------------KSEY---SVHSS-LASKVDVEQVVMYCKE BUBR1_Hsap --------KIEPSINH-ILSTRKP-----GKEEGDPLQRVQSHQQASEEK-KEKMMYCKE Bub1_Ddis --------QNNPLANFPKVSTSNS-----SSSSSSSTNKSTSTTTVTTTK-NERVGYNKP BUB1_Spur --------KPLEMGFQ-VLSEKKH-----CK----PTNALHHITKDNVKD-NTRVMYCKH CC1G_03571_Ccin ------------------------------------------------------------ CC1G_07078_Ccin -----------------------------------------------GKR-PEKLKFNMG AqueK151_Aque ------------------------------------------------------------ BUB_a-2_Smoe ------------------------------------------------------------ BUB_b-2_Smoe ------------------------------------------------------------ BUB_b-1_Smoe ------------------------------------------------------------ BUB_a-1_Smoe ------------------------------------------------------------ Bub1_Dmel LLYPRP-NIEFSPEEYRAYSF------------LKHRNPQHPFIHRNDDWWGTGRVIR-G CG14030_Dmel LVYPPGAGVEYSPEEILARKF------------KQLMDQKAKP-S-------EPPEQEQ- BUBR1_Mmus KIYA-G-VGEFSFEEIRAEVF------------RKKLKERREA-E-------LLTSAK-K BUB1_Mmus KLIR-G-DSEFSFEELRAQKY------------NQRKKHEQWV-S-------EDRNYM-K R06C7.8_Cele --------HGISIEEFRFAKW------------KDTFGEDV------------DDDY--- BUB1_Scer LIYPEN-DEEFNTEEILAMIKGLY---------KVQRRGKKHT-E-------DYTSDK-N BUB1_Hsap KLIR-G-ESEFSFEELRAQKY------------NQRRKHEQWV-N-------EDRHYM-K BUBR1_Hsap KIYA-G-VGEFSFEEIRAEVF------------RKKLKEQREA-E-------LLTSAE-K Bub1_Ddis LFTKENEKHEISFEEYRASLF------------KKKLIEKQEQ-Q-------N------- BUB1_Spur LIYG-G-AREMSFEELRGVKD------------RTKRKERDIQ-A-------KMEEAERL CC1G_03571_Ccin ------------------------------------------------------------ CC1G_07078_Ccin LLWTD-DGVEYSIQEARARSMGL------------LG----------------------- AqueK151_Aque --------LQVLPQDKSLTSF--SVYEEASINQP---SFNV------------YEEA--- BUB_a-2_Smoe ------------------------------------------------------------ BUB_b-2_Smoe ------------VDEGLARSF------------GSLVLPQ-------------------- BUB_b-1_Smoe ------------VDEGLARSF------------GSLVVPQ-------------------- BUB_a-1_Smoe ------------------------------------------------------------ Bub1_Dmel I---------------------------------------RCYPNFARYSKP---QDLDE CG14030_Dmel QTLYDSYETEKSYYMTAVDGALYGQNTSSGQENTGEEDEDND--------AE---EGEEE BUBR1_Mmus R---------------------------------------EE--------MQ---KQIEE BUB1_Mmus R---------------------------------------KEANAFEEQLLK---QKMDE R06C7.8_Cele ----------------------------------------------------RKRKDSGV BUB1_Scer R---------------------------------------K----------K---RKLDV BUB1_Hsap R---------------------------------------KEANAFEEQLLK---QKMDE BUBR1_Hsap R---------------------------------------AE--------MQ---KQIEE Bub1_Ddis ----------------------------------------KK--------IE---KEKEE BUB1_Spur R---------------------------------------VD--------MVRKHKEHDE CC1G_03571_Ccin ------------------------------------------------------------ CC1G_07078_Ccin ------------------------------------------------------------ AqueK151_Aque ----------------------------------------------------SINQPSFK BUB_a-2_Smoe ------------------------------------------------------------ BUB_b-2_Smoe ------------------------------------------------------------ BUB_b-1_Smoe ------------------------------------------------------------ BUB_a-1_Smoe ------------------------------------------------------------ Bub1_Dmel LDKFWKPPLVPGLQVVFDKIYNE-------V--EQKEYQPE-----------------EL CG14030_Dmel EDG---------------GEENEEDDSDEEEEDDEEEEEHSGPYTNGVQFSAQTTFEQEN BUBR1_Mmus MER---------------RLKA-------------------------------------- BUB1_Mmus LHK---------------KLHQV-------V--ELS---HK-----------------DL R06C7.8_Cele VFV---------------K-HQV-------I--DTD---RQ-----------------AR BUB1_Scer L-----------------------------V--ER----RQ-----------------DL BUB1_Hsap LHK---------------KLHQV-------V--ETS---HE-----------------DL BUBR1_Hsap MEK---------------KLKE-------------------------------------- Bub1_Ddis LDI---------------KLKQE-QKEQKEK--EQKEKEQK-----------------EK BUB1_Spur MFA---------------KMQEK-------L--EQQRIQQ-----------------EQY CC1G_03571_Ccin ------------------------------------------------------------ CC1G_07078_Ccin ------------------------------------------------------------ AqueK151_Aque QSA---------------P-SAR-------P--PLQ---VL-----------------PQ BUB_a-2_Smoe ------------------------------------------------------------ BUB_b-2_Smoe ------------------------------------------------------------ BUB_b-1_Smoe ------------------------------------------------------------ BUB_a-1_Smoe ------------------------------------------------------------ Bub1_Dmel LA--AKWMEK--------RNVTVHGDFD---MEETVCLPGNKMPRRK-SFFPSSFRKSIM CG14030_Dmel RSIKIKFRKE--------PSSTYSAYTIENVYQQQ------------------------- BUBR1_Mmus -------MQA--------VQQEGAGGQ------------------QE-EKM--------- BUB1_Mmus PA--------------------------------------------------SENRPDVS R06C7.8_Cele EEVENRFNAN--LN----PRRRHLSP-----VSEKTVDDEEEK-RSRI------------ BUB1_Scer PS--------------------------------------------------SQ------ BUB1_Hsap PA--------------------------------------------------SQERSEVN BUBR1_Hsap -------IQT--------TQQERTGDQ------------------QE-ETM--------- Bub1_Ddis EELEIKLKQE--------QQEKELQYQQ---HQQK------------------------- BUB1_Spur IEL----LVK--------QKVEAMASQQ---IQPPVVQPTPVVPQQP-AQMA-------- CC1G_03571_Ccin ------------------------------------------------------------ CC1G_07078_Ccin ------------------------------------------------------KKWGPP AqueK151_Aque -DKSLTSFSVYEEASINQPSFKQSAP-----SARPP---LQVLPQD-KSLTS-------- BUB_a-2_Smoe ------------------------------------------------------------ BUB_b-2_Smoe ----------------------------------------------------SGQRTGSM BUB_b-1_Smoe ----------------------------------------------------SGKRTGSM BUB_a-1_Smoe ------------------------------------------------------------ Bub1_Dmel PRRVSSVQEEDEKKEDE--ATL--I--VK----DI--PSQVAPK--IP-ESP-------- CG14030_Dmel ------------------------------------------------------------ BUBR1_Mmus P----------------------------------------------------------- BUB1_Mmus LVC-------------------------------------VGQ----------------- R06C7.8_Cele ----------------Y--SPL--VATKDAHRPALRSKIENPPA------TVTLSS-DTK BUB1_Scer ------------------------------------------------------------ BUB1_Hsap PAR-------------------------------------MGP----------------- BUBR1_Hsap P----------------------------------------------------------- Bub1_Ddis ------------------------------------------------------------ BUB1_Spur PAH-------------P--APV--VP-------QQPA-------QVAPPQAAQGVPFAQY CC1G_03571_Ccin ------------------------------------------------------------ CC1G_07078_Ccin ------------------------------------------------------------ AqueK151_Aque FSV-------------YEEASINQPSFKQ----SA--PSARPPLQVLP-QDKSLTSFSVY BUB_a-2_Smoe ------------------------------------------------------------ BUB_b-2_Smoe PS---------------------------------------------------------- BUB_b-1_Smoe PS---------------------------------------------------------- BUB_a-1_Smoe ------------------------------------------------------------ Bub1_Dmel ----CDQIDE------------PKIKIFEDSGSPRDNF---------------------- CG14030_Dmel --------------QQQQ------------------------------------------ BUBR1_Mmus ------------------------------------------------------------ BUB1_Mmus ------------------------------NTCSQQEL---------------------- R06C7.8_Cele SASEKDVSDS------------DDADDDERLKIMTAGRKD-------------------- BUB1_Scer ------------------------------------------------------------ BUB1_Hsap ------------------------------SVGSQQEL---------------------- BUBR1_Hsap ------------------------------------------------------------ Bub1_Ddis --------------QYQQ--------------------------KQQQQ----------- BUB1_Spur A--SAQQGFQTQGSSSQATTRSH--------TSPLDSIADCTDVTKQRHRSNSGGDSTMT CC1G_03571_Ccin ------------------------------------------------------------ CC1G_07078_Ccin ------------------------------------------------------------ AqueK151_Aque EEASINQPSFKQS-APSARPPLQ--------VLPQDKSLT-------------------- BUB_a-2_Smoe ------------------------------------------------------------ BUB_b-2_Smoe ------------------------------------------------------------ BUB_b-1_Smoe ------------------------------------------------------------ BUB_a-1_Smoe ------------------------------------------------------------ Bub1_Dmel --------------------------------AVPAVPVPKIEIY-EDSEEPQPTPKTRP CG14030_Dmel ------------------------------------------------------------ BUBR1_Mmus -----------------------------------TEDPARLQIASGPQEM-----SGVP BUB1_Mmus --------------------------------RGPSLSSISHQTSESSGEKPQE-EPSVP R06C7.8_Cele -------------------------------GNPPDRST--------------------- BUB1_Scer -------------------------------------------------------PPVVP BUB1_Hsap --------------------------------RAPCLPVTYQQTPVNMEKNPREAPPVVP BUBR1_Hsap -----------------------------------TKETTKLQIASESQKI-----PGMT Bub1_Ddis ------------------------------------------------------------ BUB1_Spur CTKQLMFDDLTGAAGNFNIFCDP-------SQGPPAKPAPRYPTVAAAAKP-----PIAP CC1G_03571_Ccin ------------------------------------------------------------ CC1G_07078_Ccin ------------------------------------------------------------ AqueK151_Aque ---------------SFSVYEETSINQPSFKQSAPARPP--------------------- BUB_a-2_Smoe ------------------------------------------------------------ BUB_b-2_Smoe ------------------------------------------------------RPPQKP BUB_b-1_Smoe ------------------------------------------------------RPPQKP BUB_a-1_Smoe ------------------------------------------------------------ Bub1_Dmel FYDGD---------------ETCSTQ-MFNM----------FIKSQAVSTPKGTQ----- CG14030_Dmel ------------------------------------------------------------ BUBR1_Mmus L--------------SCSIC---------------------------------------- BUB1_Mmus LMVNAVNSTLLFPAA-NLPALPVP-V-SGQS----------LTDS----------RCVNQ R06C7.8_Cele ------------------------------------------------------------ BUB1_Scer KS-----------------------T-RIEV----------FKDD----------DNPSQ BUB1_Hsap PLANAISAALVSPATSQSIAPPVP-L-KAQT----------VTDSMFAVASK-DAGCVNK BUBR1_Hsap L--------------SSSVC---------------------------------------- Bub1_Ddis ------------------------------------------------------------ BUB1_Spur L--------------SQSMA---------------------------------------- CC1G_03571_Ccin ------------------------------------------------------------ CC1G_07078_Ccin --------------------PP-SELPYYASLAASSSSTTPV------------------ AqueK151_Aque ------------------------------------------------------------ BUB_a-2_Smoe ------------------------------------------------------------ BUB_b-2_Smoe SKGNA---------------PPLSKQ-TFSV----------FVDSELNPASK-VP----- BUB_b-1_Smoe SKGNA---------------PPLSNQ-TFSV----------FVDSELNPASK-VP----- BUB_a-1_Smoe ------------------------------------------------------------ Bub1_Dmel ---KQAPSRQFGTVLKELPLPEEAAHSVESPVETRSPTLRKQLSTILETSEHGTQSLATS CG14030_Dmel ------------------------------------------------------------ BUBR1_Mmus ----------------------------PLSSN--------------------------- BUB1_Mmus SVHEFMPQCGPETK-EVCETNK---------------------------VASIND----- R06C7.8_Cele ------------------------------------------------------------ BUB1_Scer STHHKNTQVQVQTTTSILPLKP---------------------------VVDGNL----- BUB1_Hsap STHEFKPQSGAEIK-EGCETHK---------------------------VANTSS----- BUBR1_Hsap ----------------------------QVNCC--------------------------- Bub1_Ddis ------------------------------------------------------------ BUB1_Spur ---------------------------APTPCNPSSTSAFSVHSVGAPPSKSSQQAEQD- CC1G_03571_Ccin ------------------------------------------------------------ CC1G_07078_Ccin ---------------------------------------------------DFND----- AqueK151_Aque ------------------------------------------------------------ BUB_a-2_Smoe ------------------------------------------------------------ BUB_b-2_Smoe ------------------GL-----------------------------HENGAQ----- BUB_b-1_Smoe ------------------GL-----------------------------HENGAQ----- BUB_a-1_Smoe ------------------------------------------------------------ Bub1_Dmel GTTTKSTITSTSS--PGSNAVSKLGSK-----------IEENTPGQMRLQRVISAGVS-- CG14030_Dmel ------------------------------------------------------------ BUBR1_Mmus ------------------------------------------------------------ BUB1_Mmus ------------------------------------------------------------ R06C7.8_Cele ------SISSNYS--TASARTSKSGAG--------------------------------- BUB1_Scer ------------------------------------------------------------ BUB1_Hsap ------------------------------------------------------------ BUBR1_Hsap ------------------------------------------------------------ Bub1_Ddis ------------------------------------------------------------ BUB1_Spur ------TITPNQSFATNTSSTIPHGAGLNDDKTPQSSMMSEKTPSSA------SFASLSR CC1G_03571_Ccin --------------------------------------------RVV------SASAASG CC1G_07078_Ccin ------------------------------------------------------------ AqueK151_Aque ------------------------------------------------------------ BUB_a-2_Smoe ------------------------------------------------------------ BUB_b-2_Smoe ------------------------------------------------------------ BUB_b-1_Smoe ------------------------------------------------------------ BUB_a-1_Smoe ------------------------------------------------------------ Bub1_Dmel ---AVLSEPEKPGGDNFLRRELWEPNAPSVPMLKSL-----RFQEDKT-ETIPRPLACFQ CG14030_Dmel -----------------------------------------------Q------------ BUBR1_Mmus ------------------------------------------------------------ BUB1_Mmus --------------------------FHTTPNT-SLGMVQ-GTPCKVQ------------ R06C7.8_Cele ------------------------------------------------------------ BUB1_Scer --------------------------AHETPVKPSL-----TSNASRS------------ BUB1_Hsap --------------------------FHTTPNT-SLGMVQ-ATPSKVQ------------ BUBR1_Hsap ------------------------------------------------------------ Bub1_Ddis -----------------------------------------QSYNPPS------------ BUB1_Spur SRNGRL------------------------------SNIR-TPKGLTA------------ CC1G_03571_Ccin SGS--------------------------------------------------------- CC1G_07078_Ccin --------------------------DNMKST-RTMGMRRRSMLGGAE------------ AqueK151_Aque ------------------------------------------------------------ BUB_a-2_Smoe ------------------------------------------------------------ BUB_b-2_Smoe --------------------------GHALPVWTNL-----GSQAERTKENVQQPTR-WN BUB_b-1_Smoe --------------------------GHALPVWTNL-----GSQAERTKENVQQPTR-WN BUB_a-1_Smoe ------------------------------------------------------------ Bub1_Dmel EDKTETLPQ---MPIALPENSMDHGSLG-AENCFSAP-QLPTLEDESDLC---------- CG14030_Dmel -------E---------------------QHQIIHQPPQ--------------------- BUBR1_Mmus ------------------------------------------------------------ BUB1_Mmus -------PSPTVH---------TKEALGFIMDMFQAPT-LPDISDDKDEWPSLDQNEDAF R06C7.8_Cele ---------LDLM---------AENKCLE------------------------------- BUB1_Scer -------PTVTAF---------SKDAINEVFSMFNQHYSTPGALLDGDD----------- BUB1_Hsap -------PSPTVH---------TKEALGFIMNMFQAPT-LPDISDDKDEWQSLDQNEDAF BUBR1_Hsap ------------------------------------------------------------ Bub1_Ddis -------PTMTIH---------TKQAFHDVMAMFSEPLE--------------------- BUB1_Spur -------PSPTIN---------TKEALGVINAMLNCSLKSNQFDLDGDFQNQVTHQEKDF CC1G_03571_Ccin ------------------------------------------------------------ CC1G_07078_Ccin -------PTVTIN---------TKEALADVFGMYNSPE---------------------- AqueK151_Aque ---------LQVL---------PQDKSMG------------------------------- BUB_a-2_Smoe ------------------------------------------------------------ BUB_b-2_Smoe EAKIPQRPS---RPVSV------------------------------------------- BUB_b-1_Smoe EAKIPQRPS---RPASV------------------------------------------- BUB_a-1_Smoe ------------------------------------------------------------ Bub1_Dmel --GLFGKTPPKT--------------------NIFGSPKRNFDPTSQLFKSTQGDRRSFA CG14030_Dmel ------------------------------------------------------------ BUBR1_Mmus ------------------------------------------------------------ BUB1_Mmus EAQ-FQKNAVSS--------------------GDWGVKKI-------------------- R06C7.8_Cele ------------------AHAMFSDTV--------------------------------- BUB1_Scer ------------------------------------------------------------ BUB1_Hsap EAQ-FQKNVRSS--------------------GAWGVNKII------------------- BUBR1_Hsap ------------------------------------------------------------ Bub1_Ddis ------------------------------------------------------------ BUB1_Spur EMD-FA-NAESNDVKPVSKGAVFEDSSAFKRVGGFGSQGI-------------------- CC1G_03571_Ccin ------------------------------------------------------------ CC1G_07078_Ccin ------------------------------------------------------------ AqueK151_Aque ------------------SFSVYEE----------------------------------- BUB_a-2_Smoe ------------------------------------------------------------ BUB_b-2_Smoe ------------------------------------------------------------ BUB_b-1_Smoe ------------------------------------------------------------ BUB_a-1_Smoe ------------------------------------------------------------ Bub1_Dmel VTGNKLEAAPSISNLQDSFMCDLSFVPETQP-------------EA-------------- CG14030_Dmel ---------------------------------------------AVHHPSP-------- BUBR1_Mmus ---------------------------------PREISPAENILQE-------------- BUB1_Mmus ------------------------------------------------------------ R06C7.8_Cele -------------------------HL-------------ASEKTM-VLGDDSVFVPERS BUB1_Scer ------------------------------------------------------------ BUB1_Hsap ------------------------------------------------------------ BUBR1_Hsap ---------------------------------ARETSLAENIWQE-------------- Bub1_Ddis ---------------------------------------------F-EKNNKST-SSSSS BUB1_Spur -------------------------IPRRQPLTQRTDQPTEPPRQG-------------- CC1G_03571_Ccin ------------------------------------------------------------ CC1G_07078_Ccin ---------------------------KTHKFTPGSKHAPLKKIEPATPMVIPKPTFSNE AqueK151_Aque -------------------------ASINQPSFKQSAPPAKPPLQV-L------------ BUB_a-2_Smoe ------------------------------------------------------------ BUB_b-2_Smoe ------------------------------------------------------------ BUB_b-1_Smoe ------------------------------------------------------------ BUB_a-1_Smoe ------------------------------------------------------------ Bub1_Dmel VAK------------------------------------S------------------GA CG14030_Dmel ---D-----------------------------------P------------------AP BUBR1_Mmus QPDS-----------------------------------K------------------GS BUB1_Mmus ---------------------------------------M------------------TL R06C7.8_Cele LATT-----------------------------------Q-------------------I BUB1_Scer ----------------------------------------------------------TT BUB1_Hsap ---------------------------------------S------------------SL BUBR1_Hsap QPHS-----------------------------------K------------------GP Bub1_Ddis LQLN-----------------------------------N------------------VP BUB1_Spur VPPS-----------------------------------SAFSSIPIYQDDMKPEIKEAG CC1G_03571_Ccin --GS-----------------------------------SG-----------------SS CC1G_07078_Ccin NENAKTPSLSFRPFVDENAKTPSLSFRPFVDENAQSKMTT------------------PA AqueK151_Aque -PQD-----------------------------------K-------------------S BUB_a-2_Smoe ------------------------------------------------------------ BUB_b-2_Smoe -----------------------------------------------------------S BUB_b-1_Smoe -----------------------------------------------------------S BUB_a-1_Smoe ------------------------------------------------------------ Bub1_Dmel IQKFDIFL-------------------------------------DDT------------ CG14030_Dmel ASPIPIQRQ--------------------------------------------------- BUBR1_Mmus SMPFSIFD-------------------------------------ESL------------ BUB1_Mmus SSAFPIFE-------------------------------------DGN------------ R06C7.8_Cele VTDFSVLC-------------------------------------DPD------------ BUB1_Scer TSKFNVFE-------------------------------------NFT------------ BUB1_Hsap SSAFHVFE-------------------------------------DGN------------ BUBR1_Hsap SVPFSIFD-------------------------------------EFL------------ Bub1_Ddis SSPNPFTESTLMKSTIDNNKNDNNNNNNNNNNNNNNKNTDVSFDEKSI------------ BUB1_Spur ATKITIFE-------------------------------------DEP------------ CC1G_03571_Ccin GSKFAIFR-------------------------------------DPV------------ CC1G_07078_Ccin PSKLNVFV-------------------------------------DEQNKTPFITPRSAF AqueK151_Aque LTSFSVYE-------------------------------------EAS------------ BUB_a-2_Smoe -MDFNIFV-------------------------------------DDA------------ BUB_b-2_Smoe TEALDVYV-------------------------------------DE------------- BUB_b-1_Smoe TEALDVYV-------------------------------------DE------------- BUB_a-1_Smoe -MDFNIFV-------------------------------------DDA------------ . Bub1_Dmel -----------------------------------------------------------Q CG14030_Dmel ------------------------------------------------------------ BUBR1_Mmus -----------------------------------------------------------S BUB1_Mmus -----------------------------------------------------------K R06C7.8_Cele -----------------------------------------------------------P BUB1_Scer -----------------------------------------------------------Q BUB1_Hsap -----------------------------------------------------------K BUBR1_Hsap -----------------------------------------------------------L Bub1_Ddis ------------------------------------------------------------ BUB1_Spur -----------------------------------------------------------V CC1G_03571_Ccin -----------------------------------------------------------D CC1G_07078_Ccin GLKDTTTPSLTQPRNENAPRSAFKPLSTLSEESADKPVFSKVFNPPQTDVPLAPLRDVFT AqueK151_Aque -----------------------------------------------------------I BUB_a-2_Smoe ----------------------------------------------------------FC BUB_b-2_Smoe ------------------------------------------------------------ BUB_b-1_Smoe ------------------------------------------------------------ BUB_a-1_Smoe ----------------------------------------------------------FC Bub1_Dmel PK--LTK-------------------SK-------------------------------- CG14030_Dmel -----RNGSHHH------------------------------------------------ BUBR1_Mmus -DK--KDKSPAT---G----------------------GPQV------------------ BUB1_Mmus EN--YGL--------------------------------P-------------------- R06C7.8_Cele ---------TMTITQERPKKVSNGLNVVYDEAAEPEESQ-KV------------------ BUB1_Scer EF--TAK-------------------NIEDLTEV-----K-------------------- BUB1_Hsap EN--YGL--------------------------------P-------------------- BUBR1_Hsap SEK--KNKSPPA---D----------------------PPRV------------------ Bub1_Ddis EDQ--ENIDPNQ---G----------------------GGGG------------------ BUB1_Spur DNT--KENSPPS---D----------------------YRQV------------------ CC1G_03571_Ccin --A--PTPTPPA--------------------------PAAA------------------ CC1G_07078_Ccin DDH--GKPVPKP---K----------------------AMHTHERAKSHDIGADSKSPAF AqueK151_Aque NQPSFKQSAPPA---RPPLQVLPQDKSVYDEASISHPSQPQT------------------ BUB_a-2_Smoe DDR--------------------------------------------------------- BUB_b-2_Smoe ------------------------------------------------------------ BUB_b-1_Smoe ------------------------------------------------------------ BUB_a-1_Smoe DDR--------------------------------------------------------- Bub1_Dmel ------PVALMVSSFDLDCTLPETQQVAIKEPGTQQENIGHSHMIASFMKDCTEIGSCPS CG14030_Dmel ------------------------------------------------------------ BUBR1_Mmus ----LNA----------------------------------------------------Q BUB1_Mmus -----QP----------------------------------------------------K R06C7.8_Cele ----EES----------------------------------------------------E BUB1_Scer -----DP----------------------------------------------------K BUB1_Hsap -----QP----------------------------------------------------K BUBR1_Hsap ----L-A----------------------------------------------------Q Bub1_Ddis -----NN----------------------------------------------------D BUB1_Spur -----KE----------------------------------------------------K CC1G_03571_Ccin -----SS----------------------------------------------------S CC1G_07078_Ccin TPFVDEN----------------------------------------------------A AqueK151_Aque ----ASS----------------------------------------------------N BUB_a-2_Smoe ------------------------------------------------------------ BUB_b-2_Smoe ------------------------------------------------------------ BUB_b-1_Smoe ------------------------------------------------------------ BUB_a-1_Smoe ------------------------------------------------------------ Bub1_Dmel QMPASVVKT-------------------NIS-------ST-------------------- CG14030_Dmel FHPYM-----------LGQTSTPKSEANGYRR-AR--TKV-------------------- BUBR1_Mmus RRPLSVLKT------------------------TE--VGT-------------------- BUB1_Mmus NKPLGARTF-------------------GERS-------L-------------------- R06C7.8_Cele VQPEIVLVS------------------------P-------------------------- BUB1_Scer QETVSQQTT-------------------STNETNDRYERL-------------------- BUB1_Hsap NKPTGARTF-------------------GERS-------V-------------------- BUBR1_Hsap RRPLAVLKT------------------------SE--SIT-------------------- Bub1_Ddis GNPLLSSKITNRDVLMKQLFSKDEDEGNQFDQ---------------------------- BUB1_Spur REMAGVLQS------------------------SK--SVPF------------------- CC1G_03571_Ccin RKPSSSGKA------------------------TK--A---------------------- CC1G_07078_Ccin KTPFKVFSL------------------------P-------------------------- AqueK151_Aque TMPMKVLNC------------------------AP--SLSSVPLTTSDASSHCLASIEKL BUB_a-2_Smoe ------------------------------------------------------------ BUB_b-2_Smoe ------------------------------------------------------------ BUB_b-1_Smoe ------------------------------------------------------------ BUB_a-1_Smoe ------------------------------------------------------------ Bub1_Dmel -----SN---------------------KIKFSN--DSMSES------------------ CG14030_Dmel -----KR---------------------S-KFQP--DLCSNS------------------ BUBR1_Mmus -----TN---------------------E-DVSP--DICDEL------------------ BUB1_Mmus -----SK---------------------Y-SSR-----SNEM------------------ R06C7.8_Cele -VTQTSP---------------------A-TMFN--DIY--------------------- BUB1_Scer -----SN---------------------S-STRP--EKADYM------------------ BUB1_Hsap -----SR---------------------L-PSKP----KEEV------------------ BUBR1_Hsap -----SN---------------------E-DVSP--DVCDEF------------------ Bub1_Ddis ------------------------------------------------------------ BUB1_Spur ----MSL---------------------E-DQEQEDAIGMDA------------------ CC1G_03571_Ccin ------------------------------------------------------------ CC1G_07078_Ccin -------GTNDENALGRAN----------------------------------------- AqueK151_Aque SLSQKAPVTISTSLHSHNFPVPSSITNQE-QPLP--NITNPVSSTHSLPVPFSINNPLPP BUB_a-2_Smoe ------------------------------------------------------------ BUB_b-2_Smoe ------------------------------------------------------------ BUB_b-1_Smoe ------------------------------------------------------------ BUB_a-1_Smoe ------------------------------------------------------------ Bub1_Dmel -----------------------------SRKAPVNE-----------N--VGISKQPD- CG14030_Dmel -----------------------------N------SA---SSVADVASS-SVLAGAPG- BUBR1_Mmus -----------------------------TELEPLSED---AIITGFR-N-VTLCPNPE- BUB1_Mmus -----------------------------PHTDEFMDD---STVCGIRCN-KTLAPSPK- R06C7.8_Cele ------------------------------------DD---EIEFGFFK--------P-- BUB1_Scer -----------------------------TPIKETTET---DVVPIIQTPKEQIRTEDK- BUB1_Hsap -----------------------------PHAEEFLDD---STVWGIRCN-KTLAPSPK- BUBR1_Hsap -----------------------------TGIEPLSED---AIITGFR-N-VTICPNPE- Bub1_Ddis ------------------------------------ER---DMVKTIE-R-IDLLVKGK- BUB1_Spur -----------------------------MEVQPSTDPSQHRDLSHTM-N-VTLPRTGAS CC1G_03571_Ccin -------------------------------FVPFVDE---ADVK---------KPSPIP CC1G_07078_Ccin ---------------------------------PFTPK---TPTPAVFT--PFVDPKPEP AqueK151_Aque PLDALPVPQSVTTPPTNEQEAESISPESGTHSHPLVNE---TIDPSFFIP-GYLSDDPT- BUB_a-2_Smoe ------------------------------------------------------------ BUB_b-2_Smoe ------------------------------------------------------------ BUB_b-1_Smoe ------------------------------------------------------------ BUB_a-1_Smoe ------------------------------------------------------------ Bub1_Dmel EFFELN--AATEMFATNISMIK--N----------------------------------- CG14030_Dmel TFNDNA--NFSFSSATALDNSN--S----------------------------------- BUBR1_Mmus DTCDFA--RAARLASTPFHEIL--S----------------------------------- BUB1_Mmus SIGDFT--SAAQLSSTPFHKFP--A----------------------------------- R06C7.8_Cele -------SRGNFVTSTPAQ--GVH---------------LVN------------------ BUB1_Scer KSGDNT-ETQTQLTSTTIQSSP--F----------------------------------- BUB1_Hsap SPGDFT--SAAQLASTPFHKLP--V----------------------------------- BUBR1_Hsap DTCDFA--RAARFVSTPFHEIM--S----------------------------------- Bub1_Ddis DTPKFEIFEDSTLASSQLHSKS-VSLADKVASK------NKQLNPLEQSQNPLKKSILGS BUB1_Spur SNYSFE--VAARMASTPFNDAS--S----------------------------------- CC1G_03571_Ccin -P-ETP--RAATPKFTPFRDEG--D----------------------------------- CC1G_07078_Ccin AFTPFG--SSTNRAFTPFADKT--P----------------------------------- AqueK151_Aque STPCG--GRR--VGLAPFDVTAIQS-------YSPQSSNTKPLPPPPP------------ BUB_a-2_Smoe ------------------------------------------------------------ BUB_b-2_Smoe ------------------------------------------------------------ BUB_b-1_Smoe ------------------------------------------------------------ BUB_a-1_Smoe ------------------------------------------------------------ Bub1_Dmel -----------STLLIPNAK-----------VAEASEL---------------------- CG14030_Dmel -----------S-LALAVD--------------RL-------NFRD--T----------- BUBR1_Mmus -----------S-KGIAADPEGL------LQEEDLDGKAAEA--------H--------- BUB1_Mmus -----------DLVQIPEDKENV------VATQYTHMA-------------L---D---- R06C7.8_Cele ------------------------------IDEYFGNKEEES--------T---HE---- BUB1_Scer -----------LT-QPEPQAEKL------LQTAEHSEK---------------------- BUB1_Hsap -----------ESVHILEDKENV------VAKQCTQAT-------------L---D---- BUBR1_Hsap -----------L-KDLPSDPERL------LPEEDLDVKTSED--------QQ---T---- Bub1_Ddis SGINGINGNNGG-FTIFQD--------------QP-------NQEKKQP----------- BUB1_Spur -----------L-KLSFIPPMST------IKPREVEQDKEEEMVMPMQQGTVAADV---- CC1G_03571_Ccin ------------------------------------------------------------ CC1G_07078_Ccin -----------A-QSTAFKPEPEPEPEHEAYEEEHQQAYEEEEVYA-QEEEYSYDEEHIE AqueK151_Aque -----------L-PVPSLPPPPP-----PPPPSQPLP-QTDP--------A--------- BUB_a-2_Smoe ------------------------------------------------------------ BUB_b-2_Smoe ------------------------------------------------------------ BUB_b-1_Smoe ------------------------------------------------------------ BUB_a-1_Smoe ------------------------------------------------------------ Bub1_Dmel -----------------------S------------------------------------ CG14030_Dmel ------------------------------------------------------------ BUBR1_Mmus -----------------------------------------------HTVHH-------- BUB1_Mmus ----------------------SC-----------------------KENIV-------- R06C7.8_Cele ----------------------QEAP---------------------VFVAPTSSTFSKL BUB1_Scer -----------------------S-----------------------KE----------- BUB1_Hsap ----------------------SC-----------------------EENMV-------- BUBR1_Hsap ----------------------AC-----------------------GTIYS-------- Bub1_Ddis ------------------------------------------------------------ BUB1_Spur ----------------------ACSKSEVVGASASRVIQASVNESFEKTEFA-------- CC1G_03571_Ccin ------------------------------------------------------------ CC1G_07078_Ccin QYQAPLAPEHIQEGYDEGSSYHHEAP---------------------------------- AqueK151_Aque -------------------------P---------------------PIMQP-------- BUB_a-2_Smoe ------------------------------------------------------------ BUB_b-2_Smoe ------------------------------------------------------------ BUB_b-1_Smoe ------------------------------------------------------------ BUB_a-1_Smoe ------------------------------------------------------------ Bub1_Dmel ------I-YY---K-TTPL-TPKQ---------S-H-RSWS-------------QSDLET CG14030_Dmel -----SQ-QQ---I-LHPV-NKTLQIHNNNNNTS-NNNN----------------GTSTM BUBR1_Mmus ---QALI-IK---K-LSPI-IEESREA---THSS-GFSRSS----------------SSA BUB1_Mmus ---DLSK-GR---K-LGPI-QEKISA--------------S-------------LPCPSQ R06C7.8_Cele TRRKSLAANQ---A-VQPS-VTESSKP---ERSDPKDSSID----------------CLT BUB1_Scer ------------------------------------------------------------ BUB1_Hsap ---VPSR-DG---K-FSPI-QEKSPKQ---ALSS-HMYSAS-------------LLRLSQ BUBR1_Hsap ---QTLS-IK---K-LSPI-IEDSREA---THSS-GFSGSS----------------ASV Bub1_Ddis -----LQ-QS---QLQNPLKNSILGISDANGNGG-GGGS----------------G-SGS BUB1_Spur ---VDHS-AG---H-LSPI-METSAEN---ARSS-ASSSAS--------------TTNSH CC1G_03571_Ccin ------------------------------------------------------------ CC1G_07078_Ccin ---LGGR-FGQFSV-MTPI-AERTCEF---TTST-RGGTTPSDRYGRPQDGEGSPKSKHA AqueK151_Aque ---YSFR-GQ---H-LDPI-QEESRSY---CSSS-SGSTTT----------------CSS BUB_a-2_Smoe ------------------------------------------------------------ BUB_b-2_Smoe ------------------------------------------------------------ BUB_b-1_Smoe ------------------------------------------------------------ BUB_a-1_Smoe ------------------------------------------------------------ Bub1_Dmel P-------PR------E-----NFVH--------------------------PTSN---- CG14030_Dmel A-------DFSTF-----------Q-ENS-----YFAT-----QH-DT----EAQERRLS BUBR1_Mmus P-------STSSI-----------K-GFQ------------------------------- BUB1_Mmus P-------ATGGLFTQEAVFGLEAFKCTG----IDHAT----VED-LS----DANA---- R06C7.8_Cele A-------NLGRR--------LSI-GADE----IPNLT-----EN-NE----SEIT---- BUB1_Scer --------------------------------------------H-YP----TIIP---- BUB1_Hsap P-------AAGGVLTCEAELGVEACRLTD----TDAAI----AED-PP----DAIA---- BUBR1_Hsap A-------STSSI-----------K-CLQ------------------------------- Bub1_Ddis G-------GFTIF-----------Q-DQAAEEKKPFNE-----KE-QQQQEEKEKENKIE BUB1_Spur A-------SASSL-----------E-CHQ-------PS-----YH-NQ----EDREKDIA CC1G_03571_Ccin ------------------------------------------------------------ CC1G_07078_Ccin PFLRDELVAARDARRLEAELQ--DDTSEE----LMQGRDEGEDEEAYG----EDQG---- AqueK151_Aque K-------NLSTH--------SNASRSAN----ISQQS-----QH-NE----DEEP---- BUB_a-2_Smoe ------------------------------------------------------------ BUB_b-2_Smoe ------------------------------------------------------------ BUB_b-1_Smoe ------------------------------------------------------------ BUB_a-1_Smoe ------------------------------------------------------------ Bub1_Dmel ----G------------------------------------------------------- CG14030_Dmel KAVET------------------------------------------------------- BUBR1_Mmus ------------------------------------------------------------ BUB1_Mmus ----G------------------------------------------------------- R06C7.8_Cele ------------------------------------------------------------ BUB1_Scer ----P------------------------------------------------------- BUB1_Hsap ----G------------------------------------------------------- BUBR1_Hsap ------------------------------------------------------------ Bub1_Ddis EEEEEE--EKDKEKEINYQNITGN-----------ITS---------------------- BUB1_Spur PSSQGFTIHMDEEPHAQYQPKTGSAASGFHIHVDNNESSAAAPEVPTSFRAKDNSCLHKD CC1G_03571_Ccin ------------------------------------------------------------ CC1G_07078_Ccin ----G------------------------------------------------------- AqueK151_Aque ------------------------------------------P----------------- BUB_a-2_Smoe ------------------------------------------------------------ BUB_b-2_Smoe ------------------------------------------------------------ BUB_b-1_Smoe ------------------------------------------------------------ BUB_a-1_Smoe ------------------------------------------------------------ Bub1_Dmel ------------------D-------------QT---VLNETL-ADANKNPFNVELISSL CG14030_Dmel --------------------------------------IARHM-DKEAIDPFNSELCRAF BUBR1_Mmus --------------------LLE--------KLE---LTNDGA-EDAIQSPWCSQYRLQL BUB1_Mmus ------------------LQVEC---------VQT--LGNVNAPSFTVENPWDDELILKL R06C7.8_Cele -------------------GC-K---------IRR---RSEII-KQGDINPWDETLRKKL BUB1_Scer ----------------------------------F--TKIKNQPPVIIENPLSNNLRAKF BUB1_Hsap ------------------LQAEW-------MQMSS--LGTVDAPNFIVGNPWDDKLIFKL BUBR1_Hsap --------------------IPE--------KLE---LTNETS-ENPTQSPWCSQYRRQL Bub1_Ddis --------------------TI---------DPTTVIICSLTP-DDGIVNPYLIDHQYLL BUB1_Spur DLPDLEMSFIPDRTIQDAEQVEQ--------DITT--FGMGEE-PLDYSDPFNAGLQNLL CC1G_03571_Ccin ------------------------------------------------------------ CC1G_07078_Ccin ------------------LQLEERTGALSLVDTLT--LNSKF-RPPNPCNPFDPPIMSTL AqueK151_Aque -------------------EV-Q--------DLRS---LGVMN-LKRQVNPFTPETIQFM BUB_a-2_Smoe ----------------------------------------RD-RKIEFVDPWDETLVADL BUB_b-2_Smoe ------------------------------------------------------------ BUB_b-1_Smoe ------------------------------------------------------------ BUB_a-1_Smoe ----------------------------------------RD-RKSEFVDPWDETLVADL Bub1_Dmel LESIDFS----MYIE-------KLPHCQLVGHV--------KRLHPNTHLEV-H--NEKF CG14030_Dmel LAKLDFPGNHDAHASYKIVQ-TPLPK-----------------ISNTRTLNVLEGV--TF BUBR1_Mmus LKSLLE-LS--AFAEFSVED-RPMPV-----------------LEIGKEIEL-GPE--DY BUB1_Mmus LSGLSKPVT--SYSNTFEWQ-SKLPA-----------------IKTKTEYQL-G--SLLV R06C7.8_Cele MCLVRPP-Q--NM---HEFQ-ERAPK-----------------IQALRDCEV-S--GEKL BUB1_Scer LSEISPPLF--QYNTFYNYN-QELKMSSLLKKIHRVSR--NENKNPIVDFKK-T--GDLY BUB1_Hsap LSGLSKPVS--SYPNTFEWQ-CKLPA-----------------IKPKTEFQL-G--SKLV BUBR1_Hsap LKSLPE-LS--ASAELCIED-RPMPK-----------------LEIEKEIEL-GNE--DY Bub1_Ddis EQHVSATVQSI-QSFFNVGD-DLAPL-----------------PEQLD-QCEP-NQ--LF BUB1_Spur LAGLSKPLS--MYKGIYQHD-HMMPA-----------------IKTDLAVSF-GDEIHVY CC1G_03571_Ccin ------------------------------------------------------------ CC1G_07078_Ccin LSRVQTDSH--FYD-LREYSSQKLDQ--LQKFFKKGGRKNSTTVTDLFPLTL-E--NNRF AqueK151_Aque LQSLPITVT--PV---HRLP-KSSPS-----------------MTTGHTVTL-AD-GSSC BUB_a-2_Smoe LKKLAPP----------------------------------------------------- BUB_b-2_Smoe ------------------------------------------------------------ BUB_b-1_Smoe ------------------------------------------------------------ BUB_a-1_Smoe LKKLAPP----------------------------------------------------- Bub1_Dmel EVSKM--------------------IGKGAYG-SVY----VGKH---------------- CG14030_Dmel SIDKE--------------------VGRGSYG-SVY----KATD---------------- BUBR1_Mmus VIKQE-------------------HLTCDDYR-LFW----VAPR---------------- BUB1_Mmus YVNHL--------------------LGEGAFA-QVF----EAIHGDV------------- R06C7.8_Cele HIQTL--------------------IGQGGYA-KVY----RAVT---------------- BUB1_Scer CIRGE--------------------LGEGGYA-TVY----LAES---------------- BUB1_Hsap YVHHL--------------------LGEGAFA-QVY----EATQGDL------------- BUBR1_Hsap CIKRE-------------------YLICEDYK-LFW----VAPR---------------- Bub1_Ddis EDNSIIVQWPFSDITVNFTKCVCKSTMDGSMTFKVERIDDLAMT---------------- BUB1_Spur SVMEK--------------------VGEGAFA-TIY----LAACLDAL------------ CC1G_03571_Ccin ------------------------------------------------------------ CC1G_07078_Ccin MLSEK--------------------LGEGGFG-SVY----KARDLGMRTGDDDDDDDDDD AqueK151_Aque SVIGK--------------------LAKGGFA-SVY----NVKM---------------- BUB_a-2_Smoe ------------------------------------------------------------ BUB_b-2_Smoe ------------------------------------------------------------ BUB_b-1_Smoe ------------------------------------------------------------ BUB_a-1_Smoe ------------------------------------------------------------ Bub1_Dmel -------LKSGKKVALKQERPTNYWEFYICLEIHSRLTSEQM----IPSYAHIDYALVGN CG14030_Dmel -------SRTGNVVALKYQKPPNTWEIYICDQVLKRIKEPEV----LPGVMDISTAIIAP BUBR1_Mmus --------SSAELTMIKASSQPIPWDFYINLKLKERLNEDY---------DQLCSCCQYQ BUB1_Mmus ----R-NAKSEQKCILKVQRPANSWEFYIGMQLMERLKPE-V----HHMFIKFYSAHLFK R06C7.8_Cele --------DDQRTVAVKYEVPSCSWEVYICDQMRNRLKDRGLELMAKCCIMEVMDAYVYS BUB1_Scer --------SQGHLRALKVEKPASVWEYYIMSQVEFRLRKSTI----LKSIINASALHLFL BUB1_Hsap ----N-DAKNKQKFVLKVQKPANPWEFYIGTQLMERLKPS-M----QHMFMKFYSAHLFQ BUBR1_Hsap --------NSAELTVIKVSSQPVPWDFYINLKLKERLNEDF---------DHFCSCYQYQ Bub1_Ddis -------TSEDSWLSCKVQDPPSIWEFYIGNQIHQRLQERSLTI-SNSKFPTIHSLYYYT BUB1_Spur --DMTDLDRDFRRVALKVQHPPCPWEMYVIKELHARLSRLPSQIDVRPSIMTAECAHIYQ CC1G_03571_Ccin ------------------------------------------------------------ CC1G_07078_Ccin FDDFDDDEENASMVAIKVVKPRNLWEYHALRRLHSALPANL-----RRSLVLPHGLYAYG AqueK151_Aque --------MNGSTKALKIQNPPCLWEVAIIEELHKRLKANDLLK-FSQCFMSVDAVHLYT BUB_a-2_Smoe ------------LQTCKIQKPPCPWEFYIYYQLDKRIPVEE-----RDSFGSARKMYVFS BUB_b-2_Smoe ------------------------------------------------------------ BUB_b-1_Smoe ------------------------------------------------------------ BUB_a-1_Smoe ------------LQTYKIQKPPCPWEFYIYYQLDKRIPVEE-----RDSFGSARKMYVFS Bub1_Dmel NSSVYISEF-SDYGSLIGVCNKVKSVT----NRNMDEYVVMHLSCQMLDIVDHLHAMGII CG14030_Dmel NASLIATEF-SPFGSLLDINNKIRQAT----TKVMHESLVMHFSAQICNIVDHLHRQHII BUBR1_Mmus DGHVVWYQY-INCSTLQNLLQHSE---------FVTHEIIVLIIYNLLTIVEKLHRAEIV BUB1_Mmus NGSILVGEL-YSYGTLLNVINLYKNTS----EKVMPQALVLTFAIRMLYMVEQVHSCEII R06C7.8_Cele TASLLVNQY-HEYGTLLEYANNMKDPN---------WHITCFLITQMARVVKEVHASKII BUB1_Scer DESYLVLNY-ASQGTVLDLINLQREKAID-GNGIMDEYLCMFITVELMKVLEKIHEVGII BUB1_Hsap NGSVLVGEL-YSYGTLLNAINLYKNTP----EKVMPQGLVISFAMRMLYMIEQVHDCEII BUBR1_Hsap DGCIVWHQY-INCFTLQDLLQHSE---------YITHEITVLIIYNLLTIVEMLHKAEIV Bub1_Ddis DKSIMLMDHTIDQGTLDDVVSST---N----GVPMEEPLAMFHCIELLKMIEDLHLVGII BUB1_Spur DKSCMVTEY-KSKGTLLDLINKVKAVN----KKDLSEDWVLFFAIEILQTVEYMHRCKII CC1G_03571_Ccin ------------------------------------------------------------ CC1G_07078_Ccin DESFLILDL-CTQGMLLDIVNNAASAGISQAGACLDELLVIFFTIELLRLVEGMHSAGFI AqueK151_Aque NSSIIAYNY-YPHGTLLDLVNTCRTTS-----KKLTEAVLLYYTTEICQLVEALHCCGII BUB_a-2_Smoe DCSILVAGY-GQHGTLQDVVNAYLAH-----SLKMDELLCMYYTIEMLRMLEVLHGVGII BUB_b-2_Smoe --EFT------------------------------------------------------- BUB_b-1_Smoe --EFS------------------------------------------------------- BUB_a-1_Smoe DCSILVAGY-GQHGTLQDVVNAYLAH-----SLKMDELLCMYYTIEMLRMLEVLHGVGII Bub1_Dmel HADIKPDNFLLMKPIC-----------------ADPNEVSLQLIDFGVSIDMKLFPDN-- CG14030_Dmel HADIKPDNFLLMRVPNVD-----------------SPLPSLRLIDFGCAIDMTLFPDGEK BUBR1_Mmus HGDLSPRSLILRNRIH-DPYDY-----------VNKDDHAVRIMDFSYSVDLRVQLDA-- BUB1_Mmus HGDIKPDNFILGHRFLE-------------QADE-DLATGLALIDLGQSIDMKLFPKG-- R06C7.8_Cele HGDIKPDNFMITRKID-DKWGKD----A---L-MSNDSFVIKIIDWGRAIDMMPL-KN-- BUB1_Scer HGDLKPDNCMIRLEKPGEPLGAH----YMRNGEDGWENKGIYLIDFGRSFDMTLLPPG-- BUB1_Hsap HGDIKPDNFILGNGFLE-------------QDDEDDLSAGLALIDLGQSIDMKLFPKG-- BUBR1_Hsap HGDLSPRCLILRNRIH-DPYD------------CNKNNQALKIVDFSYSVDLRVQLDV-- Bub1_Ddis HGNICANNLHFLFGQTSDWPDWT----AGE-CKGAWKSKGFTLTDFSRSIDTTIYSQD-- BUB1_Spur HGDIKPDNFLINTDND-ENFTC-----------SQEPSSLVKLIDFGRSIDMTLFPEG-- CC1G_03571_Ccin ------------------------------------------------------------ CC1G_07078_Ccin HGDLKIDNCLLRLEDVP-GGAAAWSSLYQPSGEGGWQYKGLKVIDFGRTIDTRLFPAD-- AqueK151_Aque HADIKPDNIMLRDIR--PITDY-----------TSIRGRGVCLLDFGRAIDAQSFPRG-- BUB_a-2_Smoe HADFKPDNLLIRNES---------------R-GLCLALQGLCLIDWGRSIDMRLFPEG-- BUB_b-2_Smoe ------------------------------------------------------------ BUB_b-1_Smoe ------------------------------------------------------------ BUB_a-1_Smoe HADFKPDNLLIRNDRYL-LVS-------VPR-GLCLALQGLCLIDWGRSIDMRLFPEG-- Bub1_Dmel QTFNYVHHDDL-------FK-CIEMRTGRPWTYQLDLYGLVSVMHVLL-FGRY-MEVVQR CG14030_Dmel TKFRKVVQTDG-------FT-CIEMQEGRSWSYETDLFCIAATVHVML-FGDY-MQPQKK BUBR1_Mmus FAYSGFRTAQI-------LE-GQKILANCSSPYHVDLLGIADLAHLLL-FKEH-LHVFWD BUB1_Mmus TVFTGKCETSG-------FQ-CPEMLSNKPWNYQIDYFGVAATIYCML-FGSY-MKVK-N R06C7.8_Cele QRFKGRAGTEA-------FD-CPEMVDGRSWTYQADYFGFAATMAVVV-AGKY-AQLTGA BUB1_Scer TKFKSNWKADQ-------QD-CWEMRAGKPWSYEADYYGLAGVIHSML-FGKF-IETIQL BUB1_Hsap TIFTAKCETSG-------FQ-CVEMLSNKPWNYQIDYFGVAATVYCML-FGTY-MKVK-N BUBR1_Hsap FTLSGFRTVQI-------LE-GQKILANCSSPYQVDLFGIADLAHLLL-FKEH-LQVFWD Bub1_Ddis ARYQSPIELLPIGTPLEWLKINQSSTTNVGWSYNLDYLGICKVMFHILTCGKEELKLSLS BUB1_Spur TVFTAKCKTSG-------FN-CTEMQSDQPWTYQVDYYGIAGTVHCLM-FGKY-MKVFRE CC1G_03571_Ccin ------------------------------------------------------------ CC1G_07078_Ccin QQFIAEWPTDE-------RD-CFEIREGRPWTYQTDYFGLAGIIYCML-FGKY-ITSSAV AqueK151_Aque TQFVGSCGTDS-------FQ-CIQMLNNEPWSWHTDLHCIAGTVHVLL-HLDY-MEVIKN BUB_a-2_Smoe TEFLADSKTSA-------FR-CIEMMEERPWTYQVDGYGLCCIVHCML-HGSY-MELEEE BUB_b-2_Smoe ------------------------SVASRSWNR--------------------------- BUB_b-1_Smoe ------------------------SVASRSWNR--------------------------- BUB_a-1_Smoe TEFFADSKTSA-------FR-CIEMVEERPWTYQVDGYGLCCIVHCML-HGSY-MELEEE Bub1_Dmel ------SPSTIWM---PKTNVPR-Y----FQRTMWENIFRTLLNIRDCRT---MP----N CG14030_Dmel --------GSSWE---IRQKLPR-Y----LKKHVWTKFFGDLLNMQADKL----P----A BUBR1_Mmus --------GLLWK---LSQSTSE-L----KDSELWNKFFVRILNASDKS---TVS----V BUB1_Mmus ------E-GGVWK---PEGLFRR-L----PHLDMWEEFFHIMLNIPDCHN---LP----S R06C7.8_Cele ------S-VGDYS---LNVDIKRRN----ILRDACYDVINRFLNIPSCD---SLP----D BUB1_Scer ------Q-NGRCK---LKNPFKR-Y----WKKEIWGVIFDLLLNSGQASN-QALP----M BUB1_Hsap ------E-GGECK---PEGLFRR-L----PHLDMWNEFFHVMLNIPDCHH---LP----S BUBR1_Hsap --------GSFWK---LSQNISE-L----KDGELWNKFFVRILNANDEA---TVS----V Bub1_Ddis --------QQTGKLEIINQSIIQ-KDSFSELDTLWLPFLTTLLNHNGENGNQQTTTTTYI BUB1_Spur --------GGIWK---MTSKVPR-C----AKV-DWKGFFHTLLNVPSCDP-SDLP----H CC1G_03571_Ccin ------------------AESSR-AT---AVP-VGDAVIKVKKT--G-PK-APVP----T CC1G_07078_Ccin VQVQGQHGETRYK---IGTPLKR-Y----WQADLWNRLFDILLNPTLIRPGGELP----L AqueK151_Aque ------AMTGEYV---PSKSLPR-N----YDRVLWMKFFTDLLNWSGE----GQP----D BUB_a-2_Smoe ---RSPDGGRVHK---PKASLKR-Y----WNTNVWDKFFKTLLNASPPL-----P----- BUB_b-2_Smoe --------------------------------RISTAALKVRLSRGQDIK---ID----- BUB_b-1_Smoe --------------------------------RISTAALKVRLSRGQDIK---ID----- BUB_a-1_Smoe ---RSPDGGRVHK---PKASLKR-Y----WNTNVWDKFFKTLLNASPPL-----P----- : . Bub1_Dmel --L---QQLRTQLKCALAEK---E-K-YVAE-------AI-----------SKFNTILQK CG14030_Dmel --L---HEMRLIFEEEAYRM--D--S-EL----QKQ-------------IRTLSNILHRR BUBR1_Mmus --L---GELAAEMGGAFDAT--FH-S-HLNRALWKLGKTISPEALLTQQDKQPGGSQSPA BUB1_Mmus --L---DFLRQNMKKLLEQQ--YS-N-KIKTLRNRLIVML-----------S-EYKRSRK R06C7.8_Cele --W---NILIKSFSEIWNEK--FE-ASGWRQAVSKFN-------------EACDLAANQK BUB1_Scer --TEKIVEIRNLIESHLEQH--AE-N-HLRNVILSIEEEL----SHFQ---YKGKPSRRF BUB1_Hsap --L---DLLRQKLKKVFQQH--YT-N-KIRALRNRLIVLL-----------L-ECKRSRK BUBR1_Hsap --L---GELAAEMNGVFDTT--FQ-S-HLNKALWKVGKLTS------------PGALLFQ Bub1_Ddis --L---KQQRNLFENYLQSNP-VK-S-KIKSLLRIQN------------IKLFESMKSKQ BUB1_Spur --L---GDLRRQLEKHVNPS--KK-A-DIH---------FH------------MDVLLSD CC1G_03571_Ccin SEA---EALRKDP--------------------------LK------------NYSTNDT CC1G_07078_Ccin --PKELAGVRVDMEAWLQANCNRTSN-TLKGLLKK------------------VEMSCYR AqueK151_Aque --M---KALTQPLSRKLSLN---V-S-HLKLNLNYMWT------------QMERQRGFPK BUB_a-2_Smoe -----LSSLREMLEQTIVSNAAHP-R-RLKELLIKQT----------------VMMYPRR BUB_b-2_Smoe ---------TEMLK---------------QA-------PL-----------RN-FSRELR BUB_b-1_Smoe ---------TEMLK---------------QA-------PL-----------RN-FSRELR BUB_a-1_Smoe -----LSSLREMLEQTIVSNAAHP-R-RLKELLIKQT----------------VMMYPRR