CLUSTAL W (1.83) multiple sequence alignment PRP4_Hsap_PRP4 MAAAETQSL--RE-QPE----------------------M---------ED--------- HIPK4_Hsap_HIPK MSTIQ------------------------------------------------------- HIPK3_Hsap_HIPK MASQVLVY-------------------------------P---------PY-----V--- HIPK2_Hsap_HIPK MAPVYEGMA--SH-VQVF---------------------S---------PH-----T--- HIPK1_Hsap_HIPK MASQLQVF-------------------------------S---------PP-----S--- smi35A_Dmel_DYRK2 MLDRCEMPI--Q--------------------------------------L-----D--- mnb_Dmel_DYRK1 MHHHSSPSS--SS-E--------------------------------------------- Dyrk3_Dmel_DYRK2 MINQNLTHT--GI-AQN--------------------------------NT-----E--- CG17090_Dmel_HIPK MKTSYPPKA--SD-FVDY---------------------A----------------V--- PRP4_Mmus_PRP4 MAATEPPSL--RE-QAE----------------------M---------DD--------- HIPK4_Mmus_HIPK MATIQ------------------------------------------------------- HIPK3_Mmus_HIPK MASQVLVY-------------------------------P---------PY-----V--- HIPK2_Mmus_HIPK MAPVYEGMA--SH-VQVF---------------------S---------PH-----T--- HIPK1_Mmus_HIPK MASQLQVF-------------------------------S---------PP-----S--- DYRK4_Mmus_DYRK2 MQLLRLPAL--TR-TET--------------------------------SM-----D--- DYRK3_Mmus_DYRK2 MGGAARDRG--RK-DAA--------------------------------LP-----G--- DYRK2_Mmus_DYRK2 MLTRKPSAA--AP-AAY--------------------------------PT-----G--- DYRK1B_Mmus_DYRK1 MAVPPGHGP--FS----------------------------------------------- DYRK1A_Mmus_DYRK1 MHTGGETSA--CK-P-----------------------------------S-----S--- mbk-2_Cele_DYRK2 MAALASFTR--NS-RSY----------------------GQQ-------PIDVTQ-Q--- mbk-1_Cele_DYRK1 MFPTLSSVV--ES-AAC----------------------R---------VA-----C--- hpk-1_Cele_HIPK MNFHFTLDN--DR-KRR------------------------------------------- F22D6.5_Cele_PRP4 MEDNRVEED--GE-VKS----------------------D---------VG--------- C36B7.2_Cele_DYRK2 MADIQRHFS--NL-VIGA---------------------S-------------------- C36B7.1_Cele_DYRK2 MSLLIKSVQ--IV-KLH------------------------------------------- DYRK4_Hsap_DYRK2 MQLLPPPIR--TG-TKT--------------------------------QM-----D--- DYRK3_Hsap_DYRK2 MGGTARGPG--RK-DAG--------------------------------PP-----G--- DYRK2_Hsap_DYRK2 MLTRKPSAA--AP-AAY--------------------------------PT-----G--- DYRK1B_Hsap_DYRK1 MAVPPGHGP--FS----------------------------------------------- DYRK1A_Hsap_DYRK1 MHTGGETSA--CK-P-----------------------------------S-----S--- YAK1_Scer_YAK MNSSNNNDS--SS-SNS----------------------N---------MN--------- Dyrk1_Ddis_DYRK1 MDSDAKSRN--DA--PI----------------------I-------------------- Dyrk2_Ddis_DYRK2 MTSLHKQII--ES-H----------------------------------NN-----D--- Prp4_Ddis_PRP4 MVIESEIND--KK-RGL----------------------E---------SS-----S--- YakA_Ddis_YAK MGSTTQMSD--YL-VST----------------------T---------TT--------- 22349_Tthe_YAK MKRCNQEFK--FD-QSL----------------------I---------PR--------- 10580_Tthe_DyrkP MPSFIKPKQ--ND-VS-----------------------D----------F-----F--- 22423_Tthe_DyrkP MLETCGQLM--NF-LNQA---------------------G----------L-----M--- 5306_Tthe_DYRK2 MYIFNTFIQFCSQ-TKEA---------------------EKVQSTRNSFAIDQKNKDSIL 5356_Tthe_DYRK2 MQFYNPNSS--SS-ASK----------------------NSNI------KVQ-----QNL 5655_Tthe_DYRK2 MHNNSSANN--SF-NNE----------------------QALLS-----TVDLASQDISA 15575_Tthe_PRP4 MSDKQKKKE--DGELSG----------------------E---------ED-----E--- DYRK1_Spur_DYRK1 MTIDHVRHY--RLYM-----------------------------------Q-----H--- DYRK2_Spur_DYRK2 MVDSMVDAI--AR-KPN---------------------------------L-----Q--- DYRK4_Spur_DYRK2 MPACLHGVA--SM-G--------------------------------------------- HIPKa_Spur_HIPK LYPPF---------------------------------------------------I--- HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 MSSNSASEE--EN-VKG----------------------G---------AP--------- CG7028_Dmel_PRP4 MADDKSYDS--SN-NSE----------------------T---------EE--------- CC1G_13957_Ccin_DYRK2 MSASPDPPQ--QY-K----------------------------------A---------- CC1G_04865_Ccin_PRP4 MADASPAPV--EE-PEE----------------------E---------TA--------- CC1G_14245_Ccin_YAK MQDSNESSF--DL-PRW---------------------------------Q--------- AqueK110_Aque_DYRK1 MSKI-------------------------------------------------------- AqueK111_Aque_DYRK1 MDGSSSDSS--LQ-Q--------------------------------------------- AqueK112_Aque_DYRK2 MERGTGSTK--ER-S--------------------------------------------- AqueK113_Aque_DYRK2 MLAMYNSQS--LT-SAN------------------------------------------- AqueK114_Aque_HIPK MALEQQRV-----------------------------------------PL-----G--- AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 MDSCIFVIM--AE-RKL----------------------S---------TG--------- DYRK2_b_Smoe_DYRK2 MAQTDRSAY--AD----------------------------------------------- DYRK2_a_Smoe_DYRK2 MAQTDRSAY--AD----------------------------------------------- DYRKP-2_Smoe_DYRKP M----------------------------------------------------------- DYRKP-1_Smoe_DYRKP MADTVGSIL--DY-LRQH---------------------H----------F-----L--- PRP4_e_Smoe_PRP4 MGRKRRSED--CQ-ISV----------------------V---------ED--------- PRP4_d_Smoe_PRP4 MGRRKRSEN--YQ-IRV----------------------E---------ED--------- PRP4_b_Smoe_PRP4 MARDGRVDD--AK-D------------------------K---------SR-----K--- PRP4_a_Smoe_PRP4 MARDGRVDD--AK-D------------------------K---------SR-----K--- PRP4_c_Smoe_PRP4 MFSETPLTE--------------------------------------------------- YAK_b_Smoe_YAK RL---T------------------------------------------------------ YAK_a_Smoe_YAK ICVRLT------------------------------------------------------ YAK_d_Smoe_YAK MYVSDQ------------------------------------------------------ GK031_Glam_DYRK1 MSGRPIIAL--TL-DIE------------------------------------------- GK034_Glam_DYRK2 MFAPGNSAR--AQ-R-----------------------------------Q-----V--- GK033_Glam_DYRK2 MDTITLIAG--FL-R-----------------------------------Q-----H--- GK032_Glam_DYRK2 MIQPEALHQ---L-IYDHVYVKYGHQLAFTIRALLNAKER----------C-----M--- PRP4_Hsap_PRP4 -------A--NS------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK YQ-----T-Q-------------------------------------------------- HIPK2_Hsap_HIPK -------L-Q-------------------------------------------------- HIPK1_Hsap_HIPK -------V-S-------------------------------------------------- smi35A_Dmel_DYRK2 -------N-E-KLRR--------------------------------------------- mnb_Dmel_DYRK1 -------V-R-------------------------------------------------- Dyrk3_Dmel_DYRK2 -------K-A-N------------------------------------------------ CG17090_Dmel_HIPK AG-----G-G-------------------------------------------------- PRP4_Mmus_PRP4 -------A-DNS------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK YQ-----T-Q-------------------------------------------------- HIPK2_Mmus_HIPK -------L-Q-------------------------------------------------- HIPK1_Mmus_HIPK -------V-S-------------------------------------------------- DYRK4_Mmus_DYRK2 -------T-N-KARK--------------------------------------------- DYRK3_Mmus_DYRK2 -------A-G-LPPQ--------------------------------------------- DYRK2_Mmus_DYRK2 -------R-G-G------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 -------V-R-------------------------------------------------- mbk-2_Cele_DYRK2 -------G-Q-R------------------------------------------------ mbk-1_Cele_DYRK1 -------P-RLS------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ---------TSS------------------------------------------------ C36B7.2_Cele_DYRK2 -P---------------------------------------------------------- C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 -------A-K-KPRK--------------------------------------------- DYRK3_Hsap_DYRK2 -------A-G-LPPQ--------------------------------------------- DYRK2_Hsap_DYRK2 -------R-G-G------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 -------V-R-------------------------------------------------- YAK1_Scer_YAK -------N-SLS------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 -------ITK-------------------------------------------------- Prp4_Ddis_PRP4 -------P-TIND----------------------------------------------- YakA_Ddis_YAK -------S-SA------------------------------------------------- 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP QN---------------------------------------------------------- 22423_Tthe_DyrkP KS---------------------------------------------------------- 5306_Tthe_DYRK2 QS-NI----S-QPES--------------------------------------------- 5356_Tthe_DYRK2 NNSQLNNA-L-SPKK--------------------------------------------- 5655_Tthe_DYRK2 QNSRFSSG-P-SPKS--------------------------------------------- 15575_Tthe_PRP4 -------Y-K--S----------------------------------------------- DYRK1_Spur_DYRK1 -------L-K-------------------------------------------------- DYRK2_Spur_DYRK2 -------A-S-R------------------------------------------------ DYRK4_Spur_DYRK2 ---------K-RPRE--------------------------------------------- HIPKa_Spur_HIPK FG-----S-Q-------------------------------------------------- HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 -------A--SK------------------------------------------------ CG7028_Dmel_PRP4 -------R-RAK------------------------------------------------ CC1G_13957_Ccin_DYRK2 -------RPA-------------------------------------------------- CC1G_04865_Ccin_PRP4 -------P-TPP------------------------------------------------ CC1G_14245_Ccin_YAK -------T-HVE------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ---------F-SYSK--------------------------------------------- AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK SN-----K-W-------------------------------------------------- AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 -------V-A-IPQT--------------------------------------------- DYRK2_a_Smoe_DYRK2 -------V-A-IPQT--------------------------------------------- DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP QA---------------------------------------------------------- PRP4_e_Smoe_PRP4 -------E---------------------------------------------------- PRP4_d_Smoe_PRP4 -------E---------------------------------------------------- PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 -------I-P------------------------GD-HFGLVITSGRSVSKGRDQASD-- GK033_Glam_DYRK2 -------G-E----NELAENVENCESLRRETRITTDLEFLLNISRGCVTVETLANRSAMI GK032_Glam_DYRK2 SK---------------------------------------------------------- PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 KEHNMASTIDKFVIHPVFFGRRRALENEFLLEMFRDIDTKVDYLGLVPVTSKRYRMSVCH GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ---------------------EK------------------------------------- HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ---------------------SS---------A-F------------------------- HIPK2_Hsap_HIPK ---------------------SS---------A-F------------------------- HIPK1_Hsap_HIPK ---------------------SS---------A-F------------------------- smi35A_Dmel_DYRK2 ---------------------DVR-LS-----G--------------------------- mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ---------------------RH------------------------------------- CG17090_Dmel_HIPK ---------------------GS---------G-F------------------------- PRP4_Mmus_PRP4 ---------------------EK------------------------------------- HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ---------------------SS---------A-F------------------------- HIPK2_Mmus_HIPK ---------------------SS---------A-F------------------------- HIPK1_Mmus_HIPK ---------------------SS---------A-F------------------------- DYRK4_Mmus_DYRK2 ---------------------R-S-LT-----T-F------------------------- DYRK3_Mmus_DYRK2 ---------------------QRR-LGDGVYDT-F------------------------- DYRK2_Mmus_DYRK2 ---------------------DT------------------------------------- DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ---------------------LA---------P--------------------------- mbk-2_Cele_DYRK2 ---------------------DR------------------------------------- mbk-1_Cele_DYRK1 ---------------------PL---------TTLFRALSFTCDLSSVFLFASPMNFYRF hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ---------------------DE------------------------------------- C36B7.2_Cele_DYRK2 ---------------------LT---------K-L------------------------- C36B7.1_Cele_DYRK2 --------------------------------A-F------------------------- DYRK4_Hsap_DYRK2 ---------------------C-D-LT-----P-F------------------------- DYRK3_Hsap_DYRK2 ---------------------QRR-LGDGVYDT-F------------------------- DYRK2_Hsap_DYRK2 ---------------------DS------------------------------------- DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ---------------------LA---------P--------------------------- YAK1_Scer_YAK ---------------------PT---------L--------------------------- Dyrk1_Ddis_DYRK1 ----------------------K---------L--------------------------- Dyrk2_Ddis_DYRK2 ---------------------LK---------S--------------------------- Prp4_Ddis_PRP4 ---------------------PK------------------------------------- YakA_Ddis_YAK ---------------------SS---------M--------------------------- 22349_Tthe_YAK ---------------------RF---------L--------------------------- 10580_Tthe_DyrkP ---------------------SQ---------S--------------------------- 22423_Tthe_DyrkP ---------------------LK---------A-F------------------------- 5306_Tthe_DYRK2 ----------------------TKNHF-----G-Y------------------------- 5356_Tthe_DYRK2 ----------------------NI-SL-----D-L------------------------- 5655_Tthe_DYRK2 ----------------------KN-FV-----P-I------------------------- 15575_Tthe_PRP4 ---------------------PK------------------------------------- DYRK1_Spur_DYRK1 ---------------------DR---------K--------------------------- DYRK2_Spur_DYRK2 ---------------------TR------------------------------------- DYRK4_Spur_DYRK2 ---------------------KNH-IS-------N------------------------- HIPKa_Spur_HIPK ---------------------SS---------A-F------------------------- HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ---------------------ED------------------------------------- CG7028_Dmel_PRP4 ---------------------HK------------------------------------- CC1G_13957_Ccin_DYRK2 ---------------------AL---------A--------------------------- CC1G_04865_Ccin_PRP4 ---------------------QK------------------------------------- CC1G_14245_Ccin_YAK ---------------------PA---------A--------------------------- AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ---------------------ATP-LL--------------------------------- AqueK113_Aque_DYRK2 ---------------------TK------------------------------------- AqueK114_Aque_HIPK ---------------------SS---------C-L------------------------- AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ---------------------EA---------A-L------------------------- PRP4_e_Smoe_PRP4 ---------------------DA------------------------------------- PRP4_d_Smoe_PRP4 ---------------------DA------------------------------------- PRP4_b_Smoe_PRP4 ---------------------RK------------------------------------- PRP4_a_Smoe_PRP4 ---------------------RK------------------------------------- PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 --------------------------------K--------------------------- GK034_Glam_DYRK2 ---------------------AP---------P--------------------------- GK033_Glam_DYRK2 KQPYQHLYLKRIFPADQKLKGLA---------P--------------------------- GK032_Glam_DYRK2 ---------------------LV---------A-S------------------------- PRP4_Hsap_PRP4 ----------------------SI------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ---------------------CSV------------------------------------ HIPK2_Hsap_HIPK ---------------------CSV------------------------------------ HIPK1_Hsap_HIPK ---------------------CSA------------------------------------ smi35A_Dmel_DYRK2 ---------------------SRL------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ----------------------QY------------------------------------ CG17090_Dmel_HIPK ---------------------CSG------------------------------------ PRP4_Mmus_PRP4 ----------------------SV------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ---------------------CSV------------------------------------ HIPK2_Mmus_HIPK ---------------------CSV------------------------------------ HIPK1_Mmus_HIPK ---------------------CSA------------------------------------ DYRK4_Mmus_DYRK2 ---------------------PIL------------------------------------ DYRK3_Mmus_DYRK2 ---------------------MMI------------------------------------ DYRK2_Mmus_DYRK2 ----------------------AV------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ----------------------SV------------------------------------ mbk-1_Cele_DYRK1 INNCSGTTCFFLENMNTADVPDNL------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ----------------------KA------------------------------------ C36B7.2_Cele_DYRK2 ---------------------WA------------------------------------- C36B7.1_Cele_DYRK2 ---------------------FQ------------------------------------- DYRK4_Hsap_DYRK2 ---------------------LVL------------------------------------ DYRK3_Hsap_DYRK2 ---------------------MMI------------------------------------ DYRK2_Hsap_DYRK2 ----------------------AV------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ----------------------VT------------------------------------ Dyrk1_Ddis_DYRK1 ----------------------SI------------------------------------ Dyrk2_Ddis_DYRK2 -----------------------------------S--------------M--------- Prp4_Ddis_PRP4 ----------------------KV------------------------------------ YakA_Ddis_YAK ----------------------VT------------------------------------ 22349_Tthe_YAK ----------------------TV------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ---------------------QD------------------------------------- 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ---------------------G-------------------------------------- 5655_Tthe_DYRK2 ---------------------T-------------------------------------- 15575_Tthe_PRP4 ----------------------QK------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ----------------------SL------------------------------------ DYRK4_Spur_DYRK2 ---------------------GAV------------------------------------ HIPKa_Spur_HIPK ---------------------CSF------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ----------------------SG------------------------------------ CG7028_Dmel_PRP4 ----------------------KA------------------------------------ CC1G_13957_Ccin_DYRK2 -----------------------------------IHDDEGTQPSDGDDQIDNCQHQHLL CC1G_04865_Ccin_PRP4 ----------------------SE------------------------------------ CC1G_14245_Ccin_YAK ----------------------QA------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ---------------------PSL------------------------------------ AqueK113_Aque_DYRK2 ----------------------TF------------------------------------ AqueK114_Aque_HIPK ---------------------W-------------------------------------- AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ----------------------VV------------------------------------ DYRK2_a_Smoe_DYRK2 ----------------------VV------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ---------------------KA------------------------------------- PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ----------------------SV------------------------------------ PRP4_a_Smoe_PRP4 ----------------------SV------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------PPPARSAAVARA------------------------ GK033_Glam_DYRK2 -----------------------DSPPAM------------------------------- GK032_Glam_DYRK2 ---------------------ES------------------------------------- PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 --------------STRAAARRSV--CLSSMSYTLGADDVTPITSNTTP----------S Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ----------------D-------------------------------M----------E 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 --------------------RRSLNGC----------DD--------------------- DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 QPLTINVSHQDNDDS--NHSRS-------------------------------------- CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ----------------E-------------------------------LAGREVSNGLFS PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 --------------------RR-------------------------------------- GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ----------------E-------------------------------P----------S PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 NNNNNNNTTTTITTTTT------------------------------------------- Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ----------------TSVTSSLDPYYFGLAESPEHNPNQLSITPDHPPPNEPVTPARNP CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 AL---------------------------------------------------------- PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ASIDRRGLVGVGELATPRWTRDPSPDPHLDDDVPPLPDR-------PEDDAPD------- CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 -------------------------------------ELLVTYGFTEGDSVHIKTFTQCN PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 --DH-------------------------------------------------------- C36B7.1_Cele_DYRK2 --LR-------------------------------------------------------- DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP --IN-------------------------------------------------------- 22423_Tthe_DyrkP --IY-------------------------------------------------------- 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 --VYCL------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 --SPWTIEAIDGELSDSDEVSAPAPFPASNNVLIFLKVKIPELPPPARPLRTRPSIADES CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP --ID-------------------------------------------------------- PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 DALL-------------------------------------------------------- PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------TPTISPLKQSTTGSIIPK Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 GGEEILYPRNVIQSVPDHPPPTVVPPLDDHIPKQPRTPASADPPISSP------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ---------------------------------------------------------N-E HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ---------------------------------------------------------K-K HIPK2_Hsap_HIPK ---------------------------------------------------------K-K HIPK1_Hsap_HIPK ---------------------------------------------------------K-K smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ---------------------------------------------------------R-D CG17090_Dmel_HIPK --------------------------------------------LGAGLS----V--R-A PRP4_Mmus_PRP4 ---------------------------------------------------------N-E HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ---------------------------------------------------------K-K HIPK2_Mmus_HIPK ---------------------------------------------------------K-K HIPK1_Mmus_HIPK ---------------------------------------------------------K-K DYRK4_Mmus_DYRK2 ---------------------------------------------------------K-A DYRK3_Mmus_DYRK2 ---------------------------------------------------------D-E DYRK2_Mmus_DYRK2 ---------------------------------------------------------R-Q DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ---------------------------------------------------------M-S mbk-1_Cele_DYRK1 ---------------------------------------------------------Q-S hpk-1_Cele_HIPK ---------------------------------------------------------R-S F22D6.5_Cele_PRP4 ---------------------------------------------------------S-D C36B7.2_Cele_DYRK2 -------G---------T---------------------------KGGVA----T-NG-K C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ---------------------------------------------------------K-A DYRK3_Hsap_DYRK2 ---------------------------------------------------------D-E DYRK2_Hsap_DYRK2 ---------------------------------------------------------R-Q DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ---------------------------------------------------------HSD Dyrk1_Ddis_DYRK1 ---------------------------------------------------------D-- Dyrk2_Ddis_DYRK2 SILVTKSGSKEEPIVSSSKSSSNSSSINNNFNNLYSASTFSSSTK--------------K Prp4_Ddis_PRP4 ---------------------------------------------------------K-V YakA_Ddis_YAK ---------------------------------------------------------M-T 22349_Tthe_YAK ---------------------------------------------------------P-N 10580_Tthe_DyrkP ------------------------------------------------I-------LE-Q 22423_Tthe_DyrkP ------------------------------------------------IQ----S-QQ-Q 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ---------------------------------------------------------K-S DYRK1_Spur_DYRK1 -------------------------------------------TE--------------Q DYRK2_Spur_DYRK2 ---------------------------------------------------------T-Q DYRK4_Spur_DYRK2 ---------------------------------------------------------K-A HIPKa_Spur_HIPK ---------------------------------------------------------K-K HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------PSAFSSSTR--------------K CC1G_04865_Ccin_PRP4 ---------------------------------------------------------E-E CC1G_14245_Ccin_YAK ----------------------------------------------------------T- AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ---------------------------------------------------------T-S AqueK113_Aque_DYRK2 ---------------------------------------------------------N-R AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP -----------------V---------------------------DLGVQSNKVP-AK-E PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ---------------------------------------------------------E-D PRP4_a_Smoe_PRP4 ---------------------------------------------------------E-D PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 -----------------------------------------------------------P GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 -------V---------T---------------------------GSSIE----PTVD-V PRP4_Hsap_PRP4 E----------------------------------------------------------- HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK L----------------------------------------------------------- HIPK2_Hsap_HIPK L----------------------------------------------------------- HIPK1_Hsap_HIPK L----------------------------------------------------------- smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 S----GLQYLTR------------------------------------------------ CG17090_Dmel_HIPK T----------------------------------------------------------- PRP4_Mmus_PRP4 E----------------------------------------------------------- HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK L----------------------------------------------------------- HIPK2_Mmus_HIPK L----------------------------------------------------------- HIPK1_Mmus_HIPK L----------------------------------------------------------- DYRK4_Mmus_DYRK2 R----------------------------------------------------------- DYRK3_Mmus_DYRK2 T----------------------------------------------------------- DYRK2_Mmus_DYRK2 L----------------------------------------------------------- DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 L----------DAQGRSVSHEC--PTSTTLV---------RQ------------------ mbk-1_Cele_DYRK1 ----WG------------------------------------------------------ hpk-1_Cele_HIPK L----------------------------------------------------------- F22D6.5_Cele_PRP4 S----------------------------------------------------------- C36B7.2_Cele_DYRK2 Q----------------------------------------------------------- C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 R----------------------------------------------------------- DYRK3_Hsap_DYRK2 T----------------------------------------------------------- DYRK2_Hsap_DYRK2 L----------------------------------------------------------- DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ASMGSG------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 V----------------------------------------------------------- Prp4_Ddis_PRP4 E----------------------------------------------------------- YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP L----------------------------------------------------------- 22423_Tthe_DyrkP Q----------------------------------------------------------- 5306_Tthe_DYRK2 --------------QNQLAHQQIQQ-Q-QLQQQQQSLQQMQQQQQQMTLQQSQNQLNQQH 5356_Tthe_DYRK2 --------------SRKI-----SPLDNSLRKR-------IEYQ---------------- 5655_Tthe_DYRK2 --------------AKNASNQQAIVMN-AIKSKIQNIFQQQQQQ---------------- 15575_Tthe_PRP4 D----------------------------------------------------------- DYRK1_Spur_DYRK1 L----------------------------------------------------------- DYRK2_Spur_DYRK2 G----------------------------------------------------------- DYRK4_Spur_DYRK2 S----------------------------------------------------------- HIPKa_Spur_HIPK G----------------------------------------------------------- HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 A----------------------------------------------------------- CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK -PYLYG------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 P----------------------------------------------------------- AqueK113_Aque_DYRK2 T----------------------------------------------------------- AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 E----------------------------------------------------------- PRP4_a_Smoe_PRP4 E----------------------------------------------------------- PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 Y----------------------------------------------------------- GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 L----------------------------------------------------------- PRP4_Hsap_PRP4 -------------------------------------------------------N---- HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK -------------------------------------------------------K---- HIPK2_Hsap_HIPK -------------------------------------------------------K---- HIPK1_Hsap_HIPK -------------------------------------------------------K---- smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 -------------------------------------------------------C---- CG17090_Dmel_HIPK -------------------------------------------------------S---- PRP4_Mmus_PRP4 -------------------------------------------------------N---- HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK -------------------------------------------------------K---- HIPK2_Mmus_HIPK -------------------------------------------------------K---- HIPK1_Mmus_HIPK -------------------------------------------------------K---- DYRK4_Mmus_DYRK2 ----------------------------------------KK----------QSF----- DYRK3_Mmus_DYRK2 -------------------------------------------------------K---- DYRK2_Mmus_DYRK2 -------------------------------------------------------Q---- DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 -----------------LYLP----------------QIPQS----------ASFA---- mbk-1_Cele_DYRK1 -------------------------------------------------------Q---- hpk-1_Cele_HIPK -------------------------------------------------------S---- F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ---------------------------------------------------------HHE C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ----------------------------------------KK----------QKF----- DYRK3_Hsap_DYRK2 -------------------------------------------------------K---- DYRK2_Hsap_DYRK2 -------------------------------------------------------Q---- DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK -------------------------------------------------------R---- Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 -------------------------------------------------------H---- Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP -------------------------------------------------------K-TQN 5306_Tthe_DYRK2 QQQLIMMIQQQQQQQHGQQLPNQTSSKKSNQQQQMQQNQ---------------IQ---- 5356_Tthe_DYRK2 -----------------RD----------------------------------------- 5655_Tthe_DYRK2 -----------------RQQP----------------QQ---------------LQ---- 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 -------------------------------------------------------N---- DYRK2_Spur_DYRK2 -------------------------------------------------------D---- DYRK4_Spur_DYRK2 ----------------------------------------------------QPI----- HIPKa_Spur_HIPK -------------------------------------------------------H---- HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 -------------------------------------------------------RKR-- CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK -------------------------------------------------------P---- AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 -----------------------------------------RGSENGGSHFDRSF----- AqueK113_Aque_DYRK2 -------------------------------------------------------L---- AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP -------------------------------------------------------L-AED PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 -------------------------------------------------------K---- GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 -------------------------------------------------------QTHQD PRP4_Hsap_PRP4 ---------------------------------G-------------------------- HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ---------------------------------V-------------------------- HIPK2_Hsap_HIPK ---------------------------------I-------------------------- HIPK1_Hsap_HIPK ---------------------------------I-------------------------- smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ---------------------------------F-------------------------- CG17090_Dmel_HIPK ---------------------------------F-------------------------- PRP4_Mmus_PRP4 ---------------------------------G-------------------------- HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ---------------------------------V-------------------------- HIPK2_Mmus_HIPK ---------------------------------V-------------------------- HIPK1_Mmus_HIPK ---------------------------------I-------------------------- DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ---------------------------------G-------------------------- DYRK2_Mmus_DYRK2 ---------------------------------A-------------------------- DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ---------------------------------A-------------------------- mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ---------------------------------I-------------------------- F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 WQR------------------------------V-------------------------- C36B7.1_Cele_DYRK2 --M------------------------------I-------------------------- DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ---------------------------------C-------------------------- DYRK2_Hsap_DYRK2 ---------------------------------A-------------------------- DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ---------------------------------A-------------------------- Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ---------------------------------E-------------------------- Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ---------------------------------E-------------------------- 22423_Tthe_DyrkP --E------------------------------N-------------------------- 5306_Tthe_DYRK2 ---------------------------------Q-------------------------- 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ---------------------------------Q-------------------------- 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ---------------------------------G-------------------------- DYRK2_Spur_DYRK2 ---------------------------------T-------------------------- DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ---------------------------------V-------------------------- HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ---------------------------------T-------------------------- CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ---------------------------------V-------------------------- AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP --ASVPSDVQNEKLLVSEVADCQRNSTLVKYYMG-------------------------- PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ---------------------------------I-------------------------- GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 --P------------------------------PLPQEINITQNIMGDQAISMVVEGKKQ PRP4_Hsap_PRP4 ----------------------EVS-------------------------------EDQS HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ----------------------EPS-------------------------------SC-- HIPK2_Hsap_HIPK ----------------------EPS-------------------------------SN-- HIPK1_Hsap_HIPK ----------------------EPS-------------------------------G--- smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ----------------------EPL-------------------------------AM-- CG17090_Dmel_HIPK ----------------------YGD-------------------------------QT-- PRP4_Mmus_PRP4 ----------------------EVS-------------------------------EDQS HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ----------------------EPS-------------------------------GC-- HIPK2_Mmus_HIPK ----------------------EPS-------------------------------SN-- HIPK1_Mmus_HIPK ----------------------EPS-------------------------------G--- DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ----------------------PPY-------------------------------SD-- DYRK2_Mmus_DYRK2 ----------------------SPG-------------------------------IG-- DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------S-------------------------------FS-- mbk-2_Cele_DYRK2 ----------------------APT-------------------------------SF-- mbk-1_Cele_DYRK1 ----------------------QPS-------------------------------SS-- hpk-1_Cele_HIPK ----------------------DID-------------------------------IN-- F22D6.5_Cele_PRP4 ----------------------EVE-------------------------------KRQR C36B7.2_Cele_DYRK2 ----------------------MTMRL---------------------D--RFFPVYD-- C36B7.1_Cele_DYRK2 ----------------------VPARV------------------------SYFPSFR-- DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ----------------------PPC-------------------------------SN-- DYRK2_Hsap_DYRK2 ----------------------SPG-------------------------------LG-- DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------S-------------------------------FS-- YAK1_Scer_YAK ----------------------SPD-------------------------------NSHM Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ----------------------RPS-------------------------------IN-- Prp4_Ddis_PRP4 ----------------------SPS-------------------------------SGKE YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ----------------------EPNFIDEYT-----------------D--DDDPG---- 22423_Tthe_DyrkP ----------------------NPQDGEKQTNSNLLKIIKKAIHQNNKK--DVIPT---- 5306_Tthe_DYRK2 ----------------------SQY-------------------------------SN-- 5356_Tthe_DYRK2 -----------------------SK-------------------------------QS-- 5655_Tthe_DYRK2 ----------------------S----------------------------------T-- 15575_Tthe_PRP4 ----------------------KDD-------------------------------R--- DYRK1_Spur_DYRK1 ------------------------D-------------------------------MS-- DYRK2_Spur_DYRK2 ----------------------ATT----------------------------------- DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ----------------------DHV-------------------------------AA-- HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ---------------------------------------------------------KQR CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ----------------------ILA-------------------------------ER-- CC1G_14245_Ccin_YAK ----------------------PPP-------------------------------SQH- AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ----------------------YPS-------------------------------SE-- AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ----------------------VPKSTEQTTS----------------ASVQAGPE---- PRP4_e_Smoe_PRP4 ----------------------MV------------------------------------ PRP4_d_Smoe_PRP4 ----------------------MV------------------------------------ PRP4_b_Smoe_PRP4 ----------------------QPS-------------------------------SKRR PRP4_a_Smoe_PRP4 ----------------------QPS-------------------------------SKRR PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ----------------------GPTG-TSGTN----------------L--IFAPASS-- GK033_Glam_DYRK2 ---------------------------------------------------------G-- GK032_Glam_DYRK2 LRDTCMTCDAGDFDRCLSSSKHHPSADVAVSST---------------A--KVVPS---- PRP4_Hsap_PRP4 --Q--------------------------------------------------------- HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ----------V------------------------------------------------- HIPK2_Hsap_HIPK ----------W------------------------------------------------- HIPK1_Hsap_HIPK ----------W------------------------------------------------- smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ----------L------------------------------------------------- CG17090_Dmel_HIPK ----------V------------------------------------------------- PRP4_Mmus_PRP4 --Q--------------------------------------------------------- HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ----------V------------------------------------------------- HIPK2_Mmus_HIPK ----------W------------------------------------------------- HIPK1_Mmus_HIPK ----------W------------------------------------------------- DYRK4_Mmus_DYRK2 ------------------------TSV--------------------------------- DYRK3_Mmus_DYRK2 ----------T------------------------------------------------- DYRK2_Mmus_DYRK2 ----------A------------------------------------------------- DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ----------F------------------------------------------------- mbk-2_Cele_DYRK2 --------------------------S--------------------------------- mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ----------F------------------------------------------------- F22D6.5_Cele_PRP4 TDS--------------------------------------------------------- C36B7.2_Cele_DYRK2 ----------H---------------R--------------------------------- C36B7.1_Cele_DYRK2 ----------A---------------W--------------------------------- DYRK4_Hsap_DYRK2 ------------------------TSA--------------------------------- DYRK3_Hsap_DYRK2 ----------V------------------------------------------------- DYRK2_Hsap_DYRK2 ----------A------------------------------------------------- DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ----------F------------------------------------------------- YAK1_Scer_YAK --GRGIWNPSY------------------------------------------------- Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ----------P------------------------------------------------- Prp4_Ddis_PRP4 --D--------------------------------------------------------- YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ----------VLNLLMQQQPT--------------------------------------- 5356_Tthe_DYRK2 ----------I------KQPKLTL------------------------------------ 5655_Tthe_DYRK2 ----------V------LQPSIDI------------------------------------ 15575_Tthe_PRP4 KK---------------------------------------------------------- DYRK1_Spur_DYRK1 ----------V------------------------------------------------- DYRK2_Spur_DYRK2 ----------A------------------------------------------------- DYRK4_Spur_DYRK2 ------------------------QIN--------------------------------- HIPKa_Spur_HIPK ----------A------------------------------------------------- HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 --S--------------------------------------------------------- CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------MRK--------------------------------- AqueK113_Aque_DYRK2 ----------V------KDPIVDFDPE--------------------------------- AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 --E--------------------------------------------------------- PRP4_a_Smoe_PRP4 --E--------------------------------------------------------- PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ----------I------------------------------------------------- GK033_Glam_DYRK2 ----------Y---------------ARLSNPYMDYYKGETGFARQIILGHKIEKIQSRD GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ----------------------------------------------N------------- HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ----------------------------------------------D------------- HIPK1_Hsap_HIPK ----------------------------------------------D------------- smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ---------------------------T-----------------AT------------- PRP4_Mmus_PRP4 ----------------------------------------------N------------- HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ----------------------------------------------D------------- HIPK1_Mmus_HIPK ----------------------------------------------D------------- DYRK4_Mmus_DYRK2 ------------------------------K--------------V-------------- DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------G--------------AP------------- DYRK1B_Mmus_DYRK1 ------------------------------G--------------FP------------- DYRK1A_Mmus_DYRK1 ---------------------------HAAG--------------LQ------------- mbk-2_Cele_DYRK2 ------------------------------G--------------AS------------- mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ---------------------------N-----------------DK------------- F22D6.5_Cele_PRP4 ----------------------------------------------E------------- C36B7.2_Cele_DYRK2 -----------------------------------------------ARREPL------- C36B7.1_Cele_DYRK2 -----------------------------------------------NRKEAS------- DYRK4_Hsap_DYRK2 ------------------------------K--------------V-------------- DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------G--------------AT------------- DYRK1B_Hsap_DYRK1 ------------------------------G--------------FP------------- DYRK1A_Hsap_DYRK1 ---------------------------HAAG--------------LQ------------- YAK1_Scer_YAK ----------------------------------------------V------------- Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------G--------------FRKPREALLSGNSDS Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ---------------------------HCSS--------------TQ------------- DYRK2_Spur_DYRK2 ------------------------------L--------------YP------------- DYRK4_Spur_DYRK2 ------------------------------GV-----LGRRTNG-L-------------- HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ----------------------------------------------H------------- CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ----------------------------------------------S------------- AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------GISSLSLSERESKKSH-------------- AqueK113_Aque_DYRK2 ------------------------------G--------------IP------------- AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ----------------------------------------------D------------- PRP4_a_Smoe_PRP4 ----------------------------------------------D------------- PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ---------------------------VHKA--------------VS------------- GK033_Glam_DYRK2 FEPHNIPEKKGLGLATRGTIAAAEAADPYPK--------------VP------------- GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 -KHSRHKK---KK----H-KHRSKHKK-------HKHSSEEDKDKKHK------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK -F---QE----RN----Y-----------------------------P------------ HIPK2_Hsap_HIPK -M---TGY---GS----H-----------------------------S------------ HIPK1_Hsap_HIPK -V---SGQ---SS----N-----------------------------D------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK -T---DGT---RH----Q-----------------------------E------------ PRP4_Mmus_PRP4 -KHSRHKK---KK----H-KHRSKHKK-------HKHSSEEDRDKKHK------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK -F---QE----RT----Y-----------------------------P------------ HIPK2_Mmus_HIPK -M---TGY---GS----H-----------------------------S------------ HIPK1_Mmus_HIPK -V---SGQ---SS----N-----------------------------D------------ DYRK4_Mmus_DYRK2 --------ES-------------------------------------------------- DYRK3_Mmus_DYRK2 -------FSNP------------------------------------------------- DYRK2_Mmus_DYRK2 -R---SGVGT-------------------------------------------------- DYRK1B_Mmus_DYRK1 -----------GP----Q-----------------------------E------------ DYRK1A_Mmus_DYRK1 -M---AAQ---MP----H-----------------------------S------------ mbk-2_Cele_DYRK2 -S---SSSN---H----H-----------------------------H------------ mbk-1_Cele_DYRK1 -------------YSNTQ-----QHSQ--------------------------------- hpk-1_Cele_HIPK -A---PGT---SS----D-----------------------------N------------ F22D6.5_Cele_PRP4 -RSGKDKK---KK----H-KKEKKHKK-------D---------KKHK------------ C36B7.2_Cele_DYRK2 -------H---------------------------------------------------- C36B7.1_Cele_DYRK2 -------M---------------------------------------------------- DYRK4_Hsap_DYRK2 --------GS-------------------------------------------------- DYRK3_Hsap_DYRK2 -------LCNP------------------------------------------------- DYRK2_Hsap_DYRK2 -R---SGVGT-------------------------------------------------- DYRK1B_Hsap_DYRK1 -----------GP----Q-----------------------------E------------ DYRK1A_Hsap_DYRK1 -M---AGQ---MP----H-----------------------------S------------ YAK1_Scer_YAK -N---QGS----QRSPQQ-----QHQN--------------------------------- Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 GI----IK---KP----S-----------------------------SSSTSSSSSSSST Prp4_Ddis_PRP4 ------GE---VD----EVT----SSP-------A------------S------------ YakA_Ddis_YAK -------------SQIE------------------------------------------- 22349_Tthe_YAK -------------EGVS------------------------------------------- 10580_Tthe_DyrkP -------F----------------------------------------D----------- 22423_Tthe_DyrkP -------F----------------------------------------N----------- 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ---------------------------SKRSSRS--HSSRRTNDK--------------- DYRK1_Spur_DYRK1 -L---NG----QP----A-----------------------------A------------ DYRK2_Spur_DYRK2 -H---H------------------------------------------------------ DYRK4_Spur_DYRK2 --------QS-------------------------------------------------- HIPKa_Spur_HIPK -T---HS----------------------------------------------------- HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 -SSSRHKK---HK----H-KSKKSHHK-------HKHHKE-NKDGHRR------------ CG7028_Dmel_PRP4 ----------------------KKHKK-------HKKSSTG-KTEKDR------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 --------------------------RARRAAIKA------------------------- CC1G_14245_Ccin_YAK -M---SGS---SPQRIQP-----VHQS--------------------------------- AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------H----H-----------------------------S------------ AqueK112_Aque_DYRK2 --------FT-------------------------------------------------- AqueK113_Aque_DYRK2 -K---TTTMTPAQ----E-----------------------------T------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP -------L----------------------------------------E----------- PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 -D---DGK---RK----H-K----HRK-------H------------K------------ PRP4_a_Smoe_PRP4 -D---DGK---RK----H-K----HRK-------H------------K------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 -V---P-----KQ----Y-----------------------------K------------ GK033_Glam_DYRK2 -----------VP----T-----------------------------M------------ GK032_Glam_DYRK2 -------V----------------------------------------N----------- PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 TSNIKAPIQISHSSNSGSSSSGGNNNNSDDNSGSSTIKHTAASLSKMK------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ----------------------------------------------L------------- 22423_Tthe_DyrkP ----------------------------------------------Q------------- 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 -------------SDEFELDQTGALVSKRGSLKEKSRDDARASIRKHRSLNVSTSSSTSP CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ----------------------------------------------VAEDKRRATGSAGT PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 -----------------------------------ATELVLMSDTAQ------------- PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 -----------------------------------LS----------------------- Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP -GAQDFQNKVQNINQKLFSQEETEQIMERLMNKLVAS----------------------- 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 RDSKTRERKRESIGLGLAISSSVVSPRLAERHSRQAS----------------------- CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ENAA----------------------------KVKVVGESSLESSNEGFWEQKDELLWVP PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ---------------------------------------------------------P-- Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ---------------------------------------------------------PGL 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ---------------------------------------------------------S-- CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP GTKQGPQLGKVHPLDELGFSQGRKSSQTHNDQKHKGAARHKSMEARSERSGPESTDEPQ- PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP -----------------------------------------YE----------------- 22423_Tthe_DyrkP LEDEKLNSKIEKFFDNQTFQRMVEATDVMQDISNLSFTNSFLQ----------------- 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP -------------------------------VSNIR------STRKEAAEDGKPEESCLA PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 -----------------------------------------AQ----------------- PRP4_Hsap_PRP4 ----H-KH---KH--KKHKR-----KEIIDASDKEGMSPA-KR-TKL------------- HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ----R-T---YVN--G-------------------------------------------- HIPK2_Hsap_HIPK ----K-V---YSQ--S-------------------------------------------- HIPK1_Hsap_HIPK ----K-Y---YTH--S-------------------------------------------- smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------N----DS--K-------------------------------------------- CG17090_Dmel_HIPK ----Q------------------------------------------------------- PRP4_Mmus_PRP4 ----H-KH---KH--KKHKR-----KEVIEASDKEGLSPA-KR-TKL------------- HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ----Q-I---HVN--G-------------------------------------------- HIPK2_Mmus_HIPK ----K-V---YSQ--S-------------------------------------------- HIPK1_Mmus_HIPK ----K-Y---YTH--S-------------------------------------------- DYRK4_Mmus_DYRK2 -----KP----LG--H-------------------------------------------- DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 -----GP----PS--P-------------------------------------------- DYRK1B_Mmus_DYRK1 ----H-T----------------------------------------------------- DYRK1A_Mmus_DYRK1 ----H-Q---YSD--R-------------------------------------------- mbk-2_Cele_DYRK2 ----PVY----HS--Q-------------------------------------------- mbk-1_Cele_DYRK1 ---------------MT------N------------LPPI-N-HNNL------------- hpk-1_Cele_HIPK ----E------------------------------------------------------- F22D6.5_Cele_PRP4 ----K-EK---KH--KREKE---V------EMEND-GPPA-KK-RTL------------- C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 -----KL----SV--Q-------------------------------------------- DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 -----GP----PS--P-------------------------------------------- DYRK1B_Hsap_DYRK1 ----H-T----------------------------------------------------- DYRK1A_Hsap_DYRK1 ----H-Q---YSD--R-------------------------------------------- YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ---SH-T---ISD--S-------------------------------------------- Prp4_Ddis_PRP4 ----R-ET---SS--SK-----------------L-MSPS-KNQS--------------- YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP -VPE-------------------------------------------------------- 22423_Tthe_DyrkP -KTK-------------------------------------------------------- 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------ISD--------------------- DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 -----GH----GS--H-------------------------------------------- DYRK4_Spur_DYRK2 -----EK----L---S-------------------------------------------- HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ----H-KH---KH--KKHKSKKDEE------------PPV-AT----------------- CG7028_Dmel_PRP4 ----H-VH---KK--QKKAK---KRPHRTSESTNESDAPENAK-LKLSQNCGLSSKFTEI CC1G_13957_Ccin_DYRK2 ---S-------------------------------------------------------- CC1G_04865_Ccin_PRP4 -----------KY--EGSRSVVDT-------------APG-T------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ----H-S---SSD----------------------------------------------- AqueK112_Aque_DYRK2 -----HS----LGGVH-------------------------------------------- AqueK113_Aque_DYRK2 ----KMF----SG--A-------------------------------------------- AqueK114_Aque_HIPK ------------Q--A-------------------------------------------- AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 -----------------------D------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP SRPT-------------------------------------------------------- PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ----H-RS---SH--RKHSS-----KEA--DLDAN-VVPA-AMACE-------------- PRP4_a_Smoe_PRP4 ----H-RS---SH--RKHIS-----KEV--DL--D-VVPA-AMACE-------------- PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ----H-YARDPDD--K-------------------------------------------- GK033_Glam_DYRK2 ----S-A----------------------------------------------------- GK032_Glam_DYRK2 -SPT-------------------------------------------------------- PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ---------------------PAADE---------------------SESD--------- CG7028_Dmel_PRP4 MQKASRNGADFRVGKPLLPTDPSSLVEEITKTIQNKMLPVLEVASSSSESDVPADAASPI CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 -----DDLA--------------------------------------LLEDLEKQRALIK HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 -----DDLA--------------------------------------LLEDLEKQRALIK HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 -----CD----------------------------------------------------- hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 -----E------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 -------IELEDTIPLPKFEPKIPPPPPPPNSRRESGRKERGRGGDDTLAALEKQKELLQ CG7028_Dmel_PRP4 ILSIIEDEL--------------------------------------NLEELMRQKALLQ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 AELDNELM--EGKVQSGMGLILQGYESG---SEEEGEIHE----------------KARN HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 AELDNELM--EGKVQSGMGLILQGYESG---SEEEGEIHE----------------KARN HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 AQL----LATAEDEHSGMNLIAQGYQS----DEEEGEDDE----------------SALK CG7028_Dmel_PRP4 ARLGAYM--------------------SDPEAEDKGDLLPHTHSQQLVVHTKSVLKAVTS CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 --------------------------------AEDGEIL--------------------- PRP4_a_Smoe_PRP4 --------------------------------AEDGEIL--------------------- PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 GNRSSTR------------------SSSTKGKLEL-------------VDNKITTKKRSK HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 GNRSSTR------------------SSSTRGKLEI-------------TDNKNSAKKRSK HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ----------------------------------EVDTKKDESKKKEAK----------- C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ---------------STKS--------NKKDK-----------------DHKDSSRRRSK DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------QSLSKWIRPESSSSKPSSKS-------EL-------------KDS--------- CG7028_Dmel_PRP4 V----------------------------------------------------------- CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 SRSKERTR---------------------HRSDKKKSKGGIEIVKEKTTRSKSKERKKS- HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 SRSKERTR---------------------HRSDKRKSKGAGEMLREKANRSKSKERRKS- HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 SRSKD------RKDQ------QKRKYSRS---------------------------RSRS DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------ERSEKRKREREDETSQK----KQH---------------------------RS- CG7028_Dmel_PRP4 --------------------------------------------PQ-------------- CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 -K---------------------------------------------------------- HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK -----------------R------------------------------------------ HIPK2_Hsap_HIPK -----------------K------------------------------------------ HIPK1_Hsap_HIPK -----------------K------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 -----------------E------------------------------------------ CG17090_Dmel_HIPK -----------------Q------------------------------------------ PRP4_Mmus_PRP4 -K---------------------------------------------------------- HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK -----------------R------------------------------------------ HIPK2_Mmus_HIPK -----------------K------------------------------------------ HIPK1_Mmus_HIPK -----------------K------------------------------------------ DYRK4_Mmus_DYRK2 -----------------L------------------------------------------ DYRK3_Mmus_DYRK2 -----------------S------------------------------------------ DYRK2_Mmus_DYRK2 -----------------I------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 -----------------N------------------------------------------ mbk-1_Cele_DYRK1 -T---------------------------------------------------------- hpk-1_Cele_HIPK -----------------Q------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 -----------------I------------------------------------------ DYRK3_Hsap_DYRK2 -----------------S------------------------------------------ DYRK2_Hsap_DYRK2 -----------------I------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 -----------------PRS------------------------------STMKSRSVSI Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP -------------------REFQ-----KI----------------ADQL--------AL 22423_Tthe_DyrkP -------------------QEQQ-----SI----------------LDENPPHFGMK-QQ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 YPNDRNGTKQRHLDNLY------------------------------------------- DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 -----------------V------------------------------------------ DYRK4_Spur_DYRK2 -----------------N------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 -K---------------------------------------------------------- CG7028_Dmel_PRP4 -P---------------------------------------------------------- CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 -PNPATGS--QALSTIST------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 -----------------Y------------------------------------------ AqueK113_Aque_DYRK2 -----------------V------------------------------------------ AqueK114_Aque_HIPK -----------------E------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP -------------------SSANSSNQKGGQDKARGSGDGSERSSGFPRLPPVRLKS-VE PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 -------------------E----------------------------EFYPIPAT--TI PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ----------------------------------------------------LS------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 -----------------------------------------------------SNGSLFS Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ---------------------------------------------------KCD------ 22423_Tthe_DyrkP ---------------------------------------------------PMN------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP KIPDEWVAHCRVGSDADVEMDPLDASSFALGSFLDVPVGQDILSSGTKRCAAIN------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ---------------------------------------------------P-------- PRP4_Hsap_PRP4 ------------------S----------------------------------------- HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK -----------------N------------------------------------------ HIPK2_Hsap_HIPK -----------------N------------------------------------------ HIPK1_Hsap_HIPK -----------------T------------------------------------------ smi35A_Dmel_DYRK2 -----------------D------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 -----------------D------------------------------------------ CG17090_Dmel_HIPK -----------------Q------------------------------------------ PRP4_Mmus_PRP4 ------------------S----------------------------------------- HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK -----------------N------------------------------------------ HIPK2_Mmus_HIPK -----------------N------------------------------------------ HIPK1_Mmus_HIPK -----------------T------------------------------------------ DYRK4_Mmus_DYRK2 -----------------Q------------------------------------------ DYRK3_Mmus_DYRK2 -----------------E------------------------------------------ DYRK2_Mmus_DYRK2 -----------------A------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 -----------------R------------------------------------------ mbk-2_Cele_DYRK2 -----------------S------------------------------------------ mbk-1_Cele_DYRK1 ------------------EPMNEDFQLQDVQADELQKQQKQQEQQHIQQQNA-------- hpk-1_Cele_HIPK -----------------R------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 -----------------Q------------------------------------------ DYRK3_Hsap_DYRK2 -----------------E------------------------------------------ DYRK2_Hsap_DYRK2 -----------------A------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 -----------------R------------------------------------------ YAK1_Scer_YAK ------------------------------------HHQQQQQQQQQQQQNSQFCFVNPW Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 PTNTSVNNSNNNTSSNIK------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------NNSLNS------------------ 22349_Tthe_YAK ------------------------------------NNNYDN------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 -----------------T------------------------------------------ DYRK2_Spur_DYRK2 -----------------E------------------------------------------ DYRK4_Spur_DYRK2 -----------------S------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------S----------------------------------------- CG7028_Dmel_PRP4 ------------------Q----------------------------------------- CC1G_13957_Ccin_DYRK2 ---------------SVS------------------------------------------ CC1G_04865_Ccin_PRP4 -----------------TA----------------------------------------- CC1G_14245_Ccin_YAK ------------------------------------HTGSSTRQPRISQLLE-------- AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 -----------------N------------------------------------------ AqueK113_Aque_DYRK2 -----------------T------------------------------------------ AqueK114_Aque_HIPK -----------------R------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 -----------------Q------------------------------------------ DYRK2_a_Smoe_DYRK2 -----------------Q------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------E---------------------------------------PT PRP4_a_Smoe_PRP4 ------------------E---------------------------------------PT PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 -----------------I------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ----------------------------------------------PSKR---------- HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ----------------------------------------------PSKR---------- HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK N----------------------------------------------------------- Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 -------------------SSSSRSYHDSNNGYRRKDERYSSS-------RSYDRNYRDR YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 QRTQIKNGKCNQIYGSQKRNTKFSNDKFLFSNSKNLSEAFYIDSYFYSLNSSKKDKDRD- DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ----------------------------------------------PATE---------- CG7028_Dmel_PRP4 ----------------------------------------------PSK----------- CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ----------------------------------------------PSAS---------- CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 E---------DGIVLKEEGNGSSESEK--------------------------------- PRP4_a_Smoe_PRP4 E---------DGIVLKEEGNGSSESEK-----------DVEQEIEAPKSERGSPRRSRD- PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 DISRDGDRERDRDRERDRDRDRDRDRDRDRDRDRERDRDRDRDRDRDRDRDRDRDRERER YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 -NAKEKD----------------------------------------------------- DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ---------------------------------SKSQD---------------------- HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ---------------------------------SKSQD---------------------- HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------ESSRN- C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ERDRDRNSQERGSRNSHERDYRDNRDYSRDSRDNMDSRD---NK-----------NGS-- YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ---------------------------------RS--------SGSSRVDNGDAKSSQSR CG7028_Dmel_PRP4 -------------------------------------SAAPLATATSKHANIK-KSTTHN CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ---------------------------------GSPPRDNVDR----------------- PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ---------------------------------------------QAR-KSKS------- HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ---------------------------------------------QAR-KSKS------- HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ---------------------------------------------NED-ELRN------- C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ----------------------------------------------------EEKVTNSQ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 -------------------------------------------------R---------- YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 -------------------------RK----------------------RSK-------- DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 TNRD----------------------------------------------SHI------- CG7028_Dmel_PRP4 SNESDVILLDDSSGGQRTPSPTPEKRRRHASPLPAAPRSRCRRDRRSRDRDRS------- CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ----------------------------------------------------G------- CC1G_14245_Ccin_YAK -----------------------------------------------------------Q AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ----------------------------------------------------V------- DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 -------------------------------------------------KH--------- PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 -------------------------------------------------P---------- HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 -------------------------------------------------P---------- HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 QR---------------------------------------------------------- hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 -------------------------------------------------P---------- C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK QNLVYP-------------------------------------------PQYDDLNSNES Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK -------------------------------------------------NDNT------- 22349_Tthe_YAK --------------------------------------------------E--------- 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 -----SPTK-------DKDRKNDRKR---SKSPRSSNNGK----RK-------------- DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------ASDR---------------------K---------- CG7028_Dmel_PRP4 -------------------------------------------------P---------- CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 -----TPSGVVNEAMSK------VTLAGDPGTPTVSTPGPEFLQRGSASP---------- CC1G_14245_Ccin_YAK EHSLSP-------------------------------------------PSNQ------- AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 -------------------------------------------------P---------- DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 -----------------------------------------------SSP---------- PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 --------------TLR------------------------------------------- HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------FGNSH------------------------------------------- HIPK2_Hsap_HIPK ------------IPLSQ------------------------------------------- HIPK1_Hsap_HIPK ------------LPATQ------------------------------------------- smi35A_Dmel_DYRK2 ------------LPQLC------------------------------------------- mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------FPTQP------------------------------------------- CG17090_Dmel_HIPK ------------QQLQQ------------------------------------------- PRP4_Mmus_PRP4 --------------PLR------------------------------------------- HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------FGNSH------------------------------------------- HIPK2_Mmus_HIPK ------------IPPSQ------------------------------------------- HIPK1_Mmus_HIPK ------------LPATQ------------------------------------------- DYRK4_Mmus_DYRK2 ------------KPSSK------------------------------------------- DYRK3_Mmus_DYRK2 ------------APVSR------------------------------------------- DYRK2_Mmus_DYRK2 ------------LPPLR------------------------------------------- DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ----------------Q------------------------------------------- mbk-2_Cele_DYRK2 ------------LPPNL------------------------------------------- mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------APKRR------------------------------------------- F22D6.5_Cele_PRP4 --------------PRR------------------------------------------- C36B7.2_Cele_DYRK2 ----------------L------------------------------------------- C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------KPPSN------------------------------------------- DYRK3_Hsap_DYRK2 ------------PPPPR------------------------------------------- DYRK2_Hsap_DYRK2 ------------LPPLR------------------------------------------- DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ----------------Q------------------------------------------- YAK1_Scer_YAK LDAYRRRKSSLVVPPAR------------------------------------------- Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ----------------TP------TKSSISENLDQNTPP--------------------- Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------NTTNNNN----------------------------------------------- 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ----------------F------------------------------------------- 22423_Tthe_DyrkP ----------------A------------------------------------------- 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ----------------H------------------------------------------- DYRK2_Spur_DYRK2 ------------LPPIK------------------------------------------- DYRK4_Spur_DYRK2 ------------LPPAS------------------------------------------- HIPKa_Spur_HIPK ------------CGSPH------------------------------------------- HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 --------------H--------------------------------------------- CG7028_Dmel_PRP4 --------------PRR------------------------------------------- CC1G_13957_Ccin_DYRK2 ----------------SPSSEPAPARRV-HTTDFSHLPPSPSSSSIQQFLRQTIPKEPPS CC1G_04865_Ccin_PRP4 --------------PPT------------------------------------------- CC1G_14245_Ccin_YAK ------YTPSNQAPLSR------------------------------------------- AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------APPLS------------------------------------------- AqueK113_Aque_DYRK2 ------------LPPLL------------------------------------------- AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 --------------PVL------------------------------------------- DYRK2_b_Smoe_DYRK2 ------------TPSKD------------------------------------------- DYRK2_a_Smoe_DYRK2 ------------TPSKD------------------------------------------- DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ----------------R------------------------------------------- PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 --------------DRR------------------------------------------- PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ----------------E------------------------------------------- GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 LHSPPNVAHSLLRGTQEGWSGLDDEATAEALRKLDGLTGKTARSRASMTSLGRGSSASRP CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 GTPAKSSQQWEGISGSESVRSKRISTFIREGGKEPRSTPNPSEGALDSDYVAVSVSGAIS CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 SDEPHIIQDKTPKKQSRLSFTPKRGSTSSTTYGSTPTTSSRDSAGTATTNATSVSATSGG CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 RVSSTKARRNSAGSDVSSVHSNDLTLLKDRAAHLAATGELIDDAHVPPVPPLPKDLSSYR CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 -------------------------------------------------R---------- HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK -P------------------------------------------------PT-------- HIPK2_Hsap_HIPK -P------------------------------------------------AT-------- HIPK1_Hsap_HIPK -G------------------------------------------------QA-------- smi35A_Dmel_DYRK2 -N------------------------------------------------GS-------- mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 -S------------------------------------------------NN-------- CG17090_Dmel_HIPK -Q---------------------------------------------------------- PRP4_Mmus_PRP4 -------------------------------------------------R---------- HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK -P------------------------------------------------ST-------- HIPK2_Mmus_HIPK -P------------------------------------------------AS-------- HIPK1_Mmus_HIPK -G------------------------------------------------QA-------- DYRK4_Mmus_DYRK2 -N------------------------------------------------KK-------- DYRK3_Mmus_DYRK2 -R------------------------------------------------LN-------- DYRK2_Mmus_DYRK2 -A------------------------------------------------SN-------- DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 -P------------------------------------------------SI-------- mbk-2_Cele_DYRK2 -L------------------------------------------------GS-------- mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK -A---------------------------------------------------------- F22D6.5_Cele_PRP4 -------------------------------------------------E---------- C36B7.2_Cele_DYRK2 -P------------------------------------------------MT-------- C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 -I------------------------------------------------KN-------- DYRK3_Hsap_DYRK2 -R------------------------------------------------LN-------- DYRK2_Hsap_DYRK2 -A------------------------------------------------SN-------- DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 -P------------------------------------------------NI-------- YAK1_Scer_YAK -------------------------------------------------APAPNPFQY-- Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 -P------------------------------------------------PS-------- Prp4_Ddis_PRP4 ----------------QSINN-----NTLS------------------------------ YakA_Ddis_YAK ----------------------------------------------------------NN 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP -P------------------------------------------------NR-------- 22423_Tthe_DyrkP -P------------------------------------------------GL-------- 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 -------------------------SSRSKSPKRE------------------------- DYRK1_Spur_DYRK1 -P------------------------------------------------AS-------- DYRK2_Spur_DYRK2 -S------------------------------------------------HT-------- DYRK4_Spur_DYRK2 -S------------------------------------------------GQ-------- HIPKa_Spur_HIPK -P------------------------------------------------TT-------- HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 -------------------------------------------------R---------- CC1G_13957_Ccin_DYRK2 SP------------------------------------------------PT-------- CC1G_04865_Ccin_PRP4 -------------------------------------------------S---------- CC1G_14245_Ccin_YAK -------------------------------------------------S-----ASLGG AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 -P------------------------------------------------R--------- AqueK112_Aque_DYRK2 -I------------------------------------------------NS-------- AqueK113_Aque_DYRK2 -K------------------------------------------------SS-------- AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 -------------------------------------------------R---------- DYRK2_b_Smoe_DYRK2 -W------------------------------------------------E--------- DYRK2_a_Smoe_DYRK2 -W------------------------------------------------E--------- DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP -P------------------------------------------------SV-------- PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 --------------------DNARHHSRVASPDRKRRRSKSRDRGDERSR---------- PRP4_a_Smoe_PRP4 -HRGSSVDRKRRSRSKESVRENARHHSRVASPDRKRRRSRSRDRGDERSR---------- PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 -P------------------------------------------------FS-------- GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK -----------------DSYPAYTS----------------------------------- Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK NNNNNNN--NNNNNNNNNN----------------------------------------- 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------TSSTQTFRSIPSVEDPDIRISQDSDIERAFSSDVSA CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK TSASNLASRLVRRHNQPDDLEAYNT----------------------------------- AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK --------------------------------------------------KG-------- HIPK2_Hsap_HIPK --------------------------------------------------TT-------- HIPK1_Hsap_HIPK --------------------------------------------------NS-------- smi35A_Dmel_DYRK2 --------------------------------------------------RR-------- mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 --------------------------------------------------IA-------- CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK --------------------------------------------------KG-------- HIPK2_Mmus_HIPK --------------------------------------------------TT-------- HIPK1_Mmus_HIPK --------------------------------------------------SS-------- DYRK4_Mmus_DYRK2 --------------------------------------------------LR-------- DYRK3_Mmus_DYRK2 --------------------------------------------------IT-------- DYRK2_Mmus_DYRK2 --------------------------------------------------AT-------- DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 --------------------------------------------------SD-------- mbk-2_Cele_DYRK2 --------------------------------------------------SQ-------- mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 --------------------------------------------------LS-------- C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 --------------------------------------------------SR-------- DYRK3_Hsap_DYRK2 --------------------------------------------------MT-------- DYRK2_Hsap_DYRK2 --------------------------------------------------AA-------- DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 --------------------------------------------------SD-------- YAK1_Scer_YAK --------------------------------------------------SN-------- Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 --------------------------------------------------SS-------- Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP --------------------------------------------------AT-------- 22423_Tthe_DyrkP --------------------------------------------------AN-------- 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ----------------------------------------------------------NT 5655_Tthe_DYRK2 ----------------------------------------------------------QQ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 --------------------------------------------------GS-------- DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK --------------------------------------------------MT-------- HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 GKGPRVGSSATRQSQANPNTSEAVPIVKTPSKKWSFSSALNLKLASSPSSSS-------- CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK --------------------------------------------------DN-------- AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 --------------------------------------------------VGRSKVTMG- AqueK113_Aque_DYRK2 --------------------------------------------------SN-------- AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP --------------------------------------------------SH-------- PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 --------------------------------------------------AA-------- GK033_Glam_DYRK2 --------------------------------------------------SE-------- GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 --QPPQQHQQIYQNLNNSQQYTTMQQS----------SGQNYSNQSFTTNRQNSNANYLY 5356_Tthe_DYRK2 ---------------------------SS------HNNTCN-----------LSNNQSFA 5655_Tthe_DYRK2 YKQPNQKKRDLVL---------TLK-KSTENLADSFINSCN-------ITQNGSTKSSYV 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 -----------------------------------------------------MSSTGVS AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 -LD--------------------------------------------------------- mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 -N---------------------------------------------------------- CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 -VN--------------------------------------------------------- DYRK3_Mmus_DYRK2 -TEP-------------------------------------------------------- DYRK2_Mmus_DYRK2 -TTA-------------------------------------------------------- DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 -NSASS------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 -MT--------------------------------------------------------- DYRK3_Hsap_DYRK2 -TEQ-------------------------------------------------------- DYRK2_Hsap_DYRK2 -AAA-------------------------------------------------------- DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP -------S-----QV-KKKHV--------------------------------------- 22423_Tthe_DyrkP -------QDFKLDQF-NQQTI--------------------------------------- 5306_Tthe_DYRK2 H----------------------------------------------------------- 5356_Tthe_DYRK2 Q----------------------------------------------------------- 5655_Tthe_DYRK2 R----------------------------------------------------------- 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 -T---------------------------------------------------------- HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 MA---------------------------------------------------------- AqueK113_Aque_DYRK2 -KTV-------------------------------------------------------- AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP -------G------IVEDPSASFANAGDGSAAEYPDEYWDSDAYEDDDDPGYTRRPIDDE PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 -----ASK---------------------------------------------------- GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK -----------------------------------------------SAF---------- HIPK2_Hsap_HIPK -------------------------------------------------V---------- HIPK1_Hsap_HIPK -------------------------------------------------S---------- smi35A_Dmel_DYRK2 --------------------------------------------------------GHNN mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK -------------------------------------------------Q---------- PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK -----------------------------------------------SAF---------- HIPK2_Mmus_HIPK -------------------------------------------------V---------- HIPK1_Mmus_HIPK -------------------------------------------------S---------- DYRK4_Mmus_DYRK2 --------------------------------------------------------RC-- DYRK3_Mmus_DYRK2 --------------------------------------------------LTRGHTQ--- DYRK2_Mmus_DYRK2 --------------------------------------------------HTIGGSK--- DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 -----------------------------------------------QQ----------- mbk-2_Cele_DYRK2 -------------------------------------------------NSLVQGHRN-- mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK -------------------------------------------------D---------- F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 -----------------------------------------NS----------------- C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 --------------------------------------------------------QV-- DYRK3_Hsap_DYRK2 --------------------------------------------------FTGDHTQ--- DYRK2_Hsap_DYRK2 --------------------------------------------------HTIGGSK--- DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 -----------------------------------------------QQ----------- YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 -----------------------------------------------S------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP --------------------------------------DYKNM----------------- 22423_Tthe_DyrkP --------------------------------------SN-QT----------------- 5306_Tthe_DYRK2 ----------------------------------------------------------QL 5356_Tthe_DYRK2 ----------------------------------------------------------ST 5655_Tthe_DYRK2 ----------------------------------------------------------NN 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 -----------------------------------------------QE----------- DYRK2_Spur_DYRK2 ----------------------------------------------------IGAVK--- DYRK4_Spur_DYRK2 --------------------------------------------------------TF-- HIPKa_Spur_HIPK -----------------------------------------------SIH---------- HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 -----------------------------------------------T------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 --------------------------------------------------------TR-- AqueK113_Aque_DYRK2 -----------------------------------------------------KD----- AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP KEFLASEINYPSEEERARIEHNPAQQGTTYGKYDDDDRSYVES----------------- PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 -----------------------------------------DTTSKGSS----------- GK033_Glam_DYRK2 -----------------------------------------------KQ----------- GK032_Glam_DYRK2 -----------------------------------------CE----------------- PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ---------------HVA-----A------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 -----------------------P------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 -----------------------PALGSGN------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 -----------------------F------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ---------------------NPPQS-TK------------------------------- 5356_Tthe_DYRK2 KHYQGNSSIHISGEKTLTQPNVNPSGGINTNTASNVNNSNSLIINHILDSTKSQGGTINI 5655_Tthe_DYRK2 ---------------KITQENIAPQQAQN------------------------------- 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 -----------------------P------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 -----------------------P------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ---------------------Q--T----------------------------------- HIPK2_Hsap_HIPK ---------------------S--T----------------------------------- HIPK1_Hsap_HIPK ---------------------H-------------------------------------- smi35A_Dmel_DYRK2 ----------------NENT-V--T----------------------------------- mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ---------------------Q--Q----------------------------------- PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ---------------------Q--T----------------------------------- HIPK2_Mmus_HIPK ---------------------S--T----------------------------------- HIPK1_Mmus_HIPK ---------------------H-------------------------------------- DYRK4_Mmus_DYRK2 ----------------QKIPSN--T----------------------------------- DYRK3_Mmus_DYRK2 -------------------HF-V------------------------------------- DYRK2_Mmus_DYRK2 -------------------HT-MN------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ---------------------V--S----------------------------------- mbk-2_Cele_DYRK2 -----------TLTRSYHQPSSTNSSTNNLYGPLGTISRDLKQ----------------- mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ---------------------E--E----------------------------------- F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ----------------HKNTSV--T----------------------------------- DYRK3_Hsap_DYRK2 -------------------HF-L------------------------------------- DYRK2_Hsap_DYRK2 -------------------HT-MN------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ---------------------V--S----------------------------------- YAK1_Scer_YAK ------------------------T----------------------------------- Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ---------------------T--T----------------------------------- Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------N----------------------------------- 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 --AAD------------------------------------------------------- 5356_Tthe_DYRK2 NANNISFHNQYN-------------------------------ITNLVSQMNRKRQPIGG 5655_Tthe_DYRK2 --NEPSYDEEYI------------------------------SDAKFI------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ---------------------T--P----------------------------------- DYRK2_Spur_DYRK2 -------------------KT--N------------------------------------ DYRK4_Spur_DYRK2 ----------------Q------------------------------------------- HIPKa_Spur_HIPK ---------------------R--T----------------------------------- HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ---------------------K--S----------------------------------- CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------Q----------------------------------- AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ----------------SRH----------------------------------------- AqueK113_Aque_DYRK2 -------------------TT-FA------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ---------------------V--T----------------------------------- GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ----------------------------------------------K------------- HIPK2_Hsap_HIPK ----------------------------------------------S------------- HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ----------------------------------------------H------------- PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ----------------------------------------------K------------- HIPK2_Mmus_HIPK ----------------------------------------------S------------- HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ----------------------------------------------A------------- DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 --------------------------------------------DH-------------- DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ----------------------------------------------A------------- mbk-2_Cele_DYRK2 -----------------------------------------SIRDIS------------- mbk-1_Cele_DYRK1 -----------------------------------------------F---------IAQ hpk-1_Cele_HIPK ----------------------------------------------A------------- F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ----------------------------------------------S------------- DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 --------------------------------------------DH-------------- DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ----------------------------------------------A------------- YAK1_Scer_YAK ----------------------------------------------SLAGNSSGQYPSGY Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ----------------------------------------------K------------- Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ----------------------------------------------NINNNNNNGGMVGV 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ----------------------------------------SNRRQ-N------------- 5356_Tthe_DYRK2 NVIVNNSVGQNTMISNNINQLSANVQNLNNILNYQNSGASTATNS-N------------- 5655_Tthe_DYRK2 ---------------------------------------SQINRT-K------------- 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ----------------------------------------------T------------- DYRK2_Spur_DYRK2 --------------------------------------------E--------------- DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ----------------------------------------------H------------- HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ----------------------------------------------S------------- CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ----------------------------------------------GL---------SGP AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 --------------------------------------------EA-------------- AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ----------------------------------------------T------------- GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ---IP-------------F----------------------------------------- HIPK2_Hsap_HIPK ---LP-------------V----------------------------------------- HIPK1_Hsap_HIPK ----Q-------------V----------------------------------------- smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ---IP-------------F----------------------------------------- HIPK2_Mmus_HIPK ---LP-------------I----------------------------------------- HIPK1_Mmus_HIPK ----Q-------------V----------------------------------------- DYRK4_Mmus_DYRK2 ---FP------------------------------------------------------- DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ---LP-------------Y----------------------------------------- mbk-2_Cele_DYRK2 ---PPVINSSA------------------------------------------------- mbk-1_Cele_DYRK1 -SRQPH------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 --------------------------------------YR-------------------- C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ---LP------------------------------------------------------- DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ---LS-------------Y----------------------------------------- YAK1_Scer_YAK QQQQQQ------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ---TP-------------T----------------------------------------- Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK N----------------------------------------------------------- 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP --------------------------------------FL-------------------- 22423_Tthe_DyrkP --------------------------------------NQ-------------------- 5306_Tthe_DYRK2 ---NPFSGTYSTKNTSAPQ----------------------------------------- 5356_Tthe_DYRK2 ---APRSIQFHQ--YG-------------------------------------------- 5655_Tthe_DYRK2 ---KP------------------------------------------------------- 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ---GP-------------N----------------------------------------- DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ---CP-------------W----------------------------------------- HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ---FP-------------LSPRSVGFGHGLRKSSSKEQTSSASSSKAPWSPEQPDAMASA CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK -RQQPQ------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ----P------------------------------------------------------- AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP --------------------------------------YF-------------------- PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ---QP-------------M----------------------------------------- GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 --------------------------------------FK-------------------- PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ---------------------------------------------------ATT------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 GSLASLSSLGSVRNHSLHPDTSKTPDKNRPGTGSSVSTAGLSAPSGPLSPSASIKRAQSK CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 --------------------------------------------YQLTARNMSCSMTARE C36B7.1_Cele_DYRK2 --------------------------------------------NHLTLSR-------WQ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------TTTTTTTSSSSSTSTNTT Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 RLTPSSIPFFRRSSSQSMQVPSSSGSGHPSSPPPSMPTKASRSKAS-------------T CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK -----------------------------------------------------N------ HIPK2_Hsap_HIPK -----------------------------------------------------P------ HIPK1_Hsap_HIPK -----------------------------------------------------A------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK -----------------------------------------------------T------ HIPK2_Mmus_HIPK -----------------------------------------------------P------ HIPK1_Mmus_HIPK -----------------------------------------------------A------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 -----------------------------------------------------SD----- mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 P----------------------------------------------------------- C36B7.1_Cele_DYRK2 V----------------------------------------------------------- DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 -----------------------------------------------------SD----- YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 P-----------------------------------------SKSSVDDVFARLA----- Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 -----------------------------------------------------QLLKDIL 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 -----------------------------------------------------V------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK -----------------------------------------------------S------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 PPHDISMTSVSTPGKKASVLSLGLPSLLKSSSRRSLHSDAKEAAKELQKAK--------- CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 -----------------------------------------------------SSQRSKT GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK -N---------------------------------------------------------- HIPK1_Hsap_HIPK -N---------------------------------------------------------- smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK -I---------------------------------------------------------- PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK -N---------------------------------------------------------- HIPK1_Mmus_HIPK -N---------------------------------------------------------- DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 -Q---------------------------------------------------------- mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK -V---------------------------------------------------------- F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 A----------------------------------------------------------- C36B7.1_Cele_DYRK2 A----------------------------------------------------------- DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 -Q---------------------------------------------------------- YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 -N---------------------------------------------------------- Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 SKINKEQVQQQLPYQQNQQVLRSSHMMNNSQNNSNSNVVILNNNTQNANNQNIYSSNYVN 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 -A---------------------------------------------------------- DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 TS---------------------------------------------------------- GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 --------------------------------------YPG-DI---------------- CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 --------------------------------------NGS-EM---------------- DYRK2_Mmus_DYRK2 --------------------------LHL-----N---SHG-QI---------------- DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 -------------------NPHLVNYVQTSSFDNGSYEFPSGQAQQQRRLGGSQQHL--- mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 --------------------------------------DGG-EM---------------- DYRK2_Hsap_DYRK2 --------------------------LHV-----GS-HAHG-QI---------------- DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 TNPDLSNIYNPNNLAAMNPQPSSTKSNRIHSHYFPATTKNKSNR---------------- 5356_Tthe_DYRK2 -------------------APNST--------------NKVNSSFNQFNQGGQTNNFMNL 5655_Tthe_DYRK2 ------------------PQPKKG-----------A-------T---------------- 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 -------------------------------------NVPT-GL---------------- DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 --------------------------L----------PRLS-GV---------------- AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------APLQQTA-------------------------SSLY mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------NPSL-----------------DKLNDSSFLRLKN-- 5356_Tthe_DYRK2 SSVSTSQNAQVNNSQHINNNNNGSNPIRRSKYKINTETINTQNDYSLTIDHSGGSI---- 5655_Tthe_DYRK2 ------------------------VPTN-------------------------QSINN-- 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK --------------------------------------RPR------------------- HIPK2_Hsap_HIPK ------------------------------------PSLP-------------------- HIPK1_Hsap_HIPK ------------------------------------FNIPA------------------- smi35A_Dmel_DYRK2 ---------TTSLNGNGNGNGN----SNSNNNNN--IGSPVSS---S------------- mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 -----QILPIFDCC------EI-----------------SESIQA--------------- CG17090_Dmel_HIPK ------------------------------------LRQPA------------------- PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK --------------------------------------KPR------------------- HIPK2_Mmus_HIPK ------------------------------------PSLP-------------------- HIPK1_Mmus_HIPK ------------------------------------FNLPA------------------- DYRK4_Mmus_DYRK2 ---------FVDTK------GK----R-----NT--VNFPQIG---N------------- DYRK3_Mmus_DYRK2 -----KVEQLFQEF------GN-----------------RRS-N---------------- DYRK2_Mmus_DYRK2 -----QVQQLFEDN------SN-----------------KRTVL---------------- DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------IQQPL------------------- mbk-2_Cele_DYRK2 SNPQSSSSQLLGQQ------QAVRPNY-----AY-QQSLPRQQHINSHQTQAFFGTVRGP mbk-1_Cele_DYRK1 ---------S--NI----------------------LRFP-------------------- hpk-1_Cele_HIPK ------------------------------------NAVPK------------------- F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ---------FVDTK------GK----K-----NT--VSFPHIS---K------------- DYRK3_Hsap_DYRK2 -----KVEQLFQEF------GN-----------------RKS-N---------------- DYRK2_Hsap_DYRK2 -----QVQQLFEDN------SN-----------------KRTVL---------------- DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------IQQPL------------------- YAK1_Scer_YAK ---------VYQQG----------------------AI---------------------- Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------VSKPA------------------- Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------HREPI------------------- DYRK2_Spur_DYRK2 -----QVTQLFETD------DN----H-----NF-----KRQVQ--N------------- DYRK4_Spur_DYRK2 ----------LSLGH-----NK----S-----NTMGESLPQLT---N------------- HIPKa_Spur_HIPK --------------------------------------QPP------------------- HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ---------LSQNT----------------------FY---------------------- AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ---------TSSVET-----RD----R-----SGTVPSLPQVG---N------------- AqueK113_Aque_DYRK2 -----QVQPMFRDQ------VP---LN-----DL-Q---QRRP---R------------- AqueK114_Aque_HIPK --------------------------------------GPA------------------- AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ---------------------------------T--FMTPEGK----------------- DYRK2_a_Smoe_DYRK2 ---------------------------------T--FMTPEGK----------------- DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------VRQPK------------------- GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------G----------------------------------------- HIPK2_Hsap_HIPK -----------------YE----------------------------------------- HIPK1_Hsap_HIPK -----------------YD----------------------------------------- smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------G----------------------------------------- HIPK2_Mmus_HIPK -----------------YE----------------------------------------- HIPK1_Mmus_HIPK -----------------YD----------------------------------------- DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 -----------------TN----------------------------------------- mbk-2_Cele_DYRK2 TNSTNIV----------------------------------------------------- mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ----------DL-REDSF------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 -----------------TN----------------------------------------- YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 -----------------IKSRSLSV----------------------------------- Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ----------QNNDEDDE------------------------------------------ 22423_Tthe_DyrkP ----------QH-NQLQQ------------------------------------------ 5306_Tthe_DYRK2 -----VQS---------------------------------------------------- 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 -----LQS---------------------------------------------------- 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 -----------------LQ----------------------------------------- DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 -----VQ----------------------------------------------------- HIPKa_Spur_HIPK ------------------R----------------------------------------- HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------EAARESDREKAKAEKAEKERQKKEDKDRSESRISVL CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 -----VKDGKS------RD----------------------------------------- AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ----------S-GEEYYR------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ----------AVTQTL-YQ----------------------------------------- GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ----------PLNAVYLA------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ISRKRGKTLSATDPRKPKSPVTLPPMQISAIEPVTAQRVAKLKSSSSQSTTSSINSRTSS CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 SSSRVTSQTASSMQKISDSSLRSRTQLPTIAGSPSVGTNGTNSTQNTIREKDHSSLLSSS CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK -------------------------------------------HNFS------------- HIPK2_Hsap_HIPK -------------------------------------------QTIV------------- HIPK1_Hsap_HIPK -------------------------------------------QGLL------------- smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK -------------------------------------------HSFS------------- HIPK2_Mmus_HIPK -------------------------------------------QTII------------- HIPK1_Mmus_HIPK -------------------------------------------QGLL------------- DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 -------------------------------------------Q---------------- DYRK1A_Mmus_DYRK1 -------------------------------------------Q---------------- mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 -------------------------------------------Q---------------- DYRK1A_Hsap_DYRK1 -------------------------------------------Q---------------- YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 -----------------------------SASLARVEQSPPTKD--KGDKESSSSSSSSS Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 -------------------------------------------Q---------------- DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK -------------------------------------------A---------------- HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ISGLPKETPTKIPRISSRTSAAPSPSGKSTS----------------------------- CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 -------------------------------------------QTWD------------- AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK --------------------------------------------GFI------------- AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 -------------------------------------------Q---------------- GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 SSFSSKFTKILRSSSKTP----------TPTSSNTTVQPSTTSLSASKISSRKDTK---- Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 -------TFASRRTSMNPAASSSTNPSPISLSTNEFGVIDNEDGATPRNLARQSSIRASP CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 -----------------------------SLSSFSTTTTTTTLKSS--SSSSSSSSSSSK Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 STSASRPARQSSANTSSTSSSALRKSTRESV-------SFIGLRKASTSS---------- CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------L----------------- HIPK2_Hsap_HIPK ------------------------------------------F----------------- HIPK1_Hsap_HIPK ------------------------------------------L----------------- smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------L----------------- HIPK2_Mmus_HIPK ------------------------------------------F----------------- HIPK1_Mmus_HIPK ------------------------------------------L----------------- DYRK4_Mmus_DYRK2 ------------------------------------------------KV---------- DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 --------------------------------V---------L----------------- DYRK1A_Mmus_DYRK1 --------------------------------V---------M----------------- mbk-2_Cele_DYRK2 ----------------------------------------------------TPL----- mbk-1_Cele_DYRK1 ------------------------------------------Q----------------- hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------KV---------- DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 --------------------------------V---------L----------------- DYRK1A_Hsap_DYRK1 --------------------------------V---------M----------------- YAK1_Scer_YAK ------------------------------------------H----------------- Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 SNIASSSSSSSNNLTNLLTQSQSISSTSTSTTT---------T----------------- Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 -----------------------------------------------------P------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 -----------------------------------------------------A------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 --------------------------------Q---------A----------------- DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------N----------------- AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------IYGDTEQLLLSPYSSRPR AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------L----------------- AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------TI---------- DYRK2_a_Smoe_DYRK2 ------------------------------------------------TI---------- DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 --------------------------------Q---------Q----------------- GK033_Glam_DYRK2 --------------------------------VLSRKITPRAL----------------- GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------RSQ--------------------------- HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK Q----------------------------------------------------------- HIPK2_Hsap_HIPK P-------------------------GS-------------------------------- HIPK1_Hsap_HIPK P-------------------------AP-------------------------------- smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ---------------------------T-------------------------------- PRP4_Mmus_PRP4 ------------------------------RSQ--------------------------- HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK Q----------------------------------------------------------- HIPK2_Mmus_HIPK P-------------------------GS-------------------------------- HIPK1_Mmus_HIPK P-------------------------AP-------------------------------- DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 P-------------------------DV-------------------------------- DYRK1A_Mmus_DYRK1 P-------------------------DI-------------------------------- mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 P-------------------------PITSI----------------------------- hpk-1_Cele_HIPK ---------------------------N-------------------------------- F22D6.5_Cele_PRP4 ------------------------------RSKSAERRDRELR--------ERRDAERRD C36B7.2_Cele_DYRK2 -KRI-------VRKRA--QNH--------------------------------------- C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 P-------------------------DV-------------------------------- DYRK1A_Hsap_DYRK1 P-------------------------DI-------------------------------- YAK1_Scer_YAK P-------------------------S--------------------------------- Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 P-------------------------TS-------------------------------- Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP -SQV-------LQNQQ--RNA--------------------------------------- 22423_Tthe_DyrkP -QQN-------VQNQQ--TDM--------------------------------------- 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------DSR----RDKDSKSGYRDNEKKSNY----- DYRK1_Spur_DYRK1 E-------------------------EM-------------------------------- DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------ASD--------------------------- CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------AAD--------------------------- CC1G_14245_Ccin_YAK P-------------------------S--------------------------------- AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 P-------------------------SP-------------------------------- AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK P-------------------------QA-------------------------------- AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------TDD--------------------------- DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP -GRD-------ARDN--------------------------------------------- PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 EASL-------LHGNKLGANYAGKNQPI-------------------------------- GK033_Glam_DYRK2 K-------------------------EF-------------------------------- GK032_Glam_DYRK2 -YHDIVATENVLQNGK--L----------------------------------------- PRP4_Hsap_PRP4 ----EKIGKARSPTDDKVKIEDKSKSKDRKKSPIINESRSRDRGKKSRSPVDLRGKSKDR HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ----EKVGKARSPAEEKMKSEEKGKIKDRKKSPIVNE-RSRDRSKKSKSPVDLRDKSKDR HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 RSLSK------------------------------------------------------- C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------G----------------------------- DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 --------------------------------------------------------SKDS CG7028_Dmel_PRP4 ----Q--------------------------------------QT--------------- CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ----QN------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ----Q------------------------------------------------------- DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 RSRSKERKSKRSETDKEKKPIKSPSK---------DASSGKENRSPSRRPGR-SPKRRSL HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 RSRSKERKSKRSEIDKEKKPIKSPSK---------DASSGKENRSPSRRPGR-SPKRRSL HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 DSRRDSRK-------------SSPSATKSEQRESRDSREPRDSRKSSGRDGRASPKR-EL CG7028_Dmel_PRP4 ----Q------------------------------------------------------V CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 SPKPRDKSRRSR----SPLLNDRRSKQSKSPS---RTLSPGRR----------------- HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK -------------------------------------------T---------------- HIPK2_Hsap_HIPK -------------------------------------------T---------------- HIPK1_Hsap_HIPK ------------------------------------------AV---------------- smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------S----------------- PRP4_Mmus_PRP4 SPKLRDKSRRSR----SPLLNDRRSKQSKSPS---RTLSPGRR----------------- HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK -------------------------------------------A---------------- HIPK2_Mmus_HIPK -------------------------------------------T---------------- HIPK1_Mmus_HIPK ------------------------------------------AV---------------- DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------R----------------- DYRK1A_Mmus_DYRK1 ------------------------------------------V----------------- mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------L----------------- F22D6.5_Cele_PRP4 ----------------------------------------ERR----------------- C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------R----------------- DYRK1A_Hsap_DYRK1 ------------------------------------------V----------------- YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------T----------------- Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------KQRTIRTIMPGSNRDNSV 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------Q----------------- 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------A----------------- DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 K--SGEKSRRESSRDSKPI-------RSRSPKKERVFTEPA------------------- CG7028_Dmel_PRP4 RPR--------------------------------------------------------- CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------S----------------- AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------Q----------------- AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------V----------------- GK033_Glam_DYRK2 ------------------------------------------I----------------- GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 GNNSSINRNGYFQREYSESGVDASNQYILPASLLQQKTKRSGNSITGGVNNVIANNNNSY 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ----------------------SAVV---------------------------------- HIPK2_Hsap_HIPK ----------------------GHIV---------------------------------- HIPK1_Hsap_HIPK ----------------------EHIV---------------------------------- smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ----------------------GAIV---------------------------------- HIPK2_Mmus_HIPK ----------------------GHIV---------------------------------- HIPK1_Mmus_HIPK ----------------------EHIV---------------------------------- DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 -------------------------SPTLASSMSVLSSPTSTTTTSTSTTSTT------- Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 NNGSYSKIQPHLPQNQ-------------------------------------------- 5356_Tthe_DYRK2 ---------PRYPQTETHKTGTKEI----------------------------------- 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 -----------------------------------------VNSTSTPGTSGTTSESSGS CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 -------------------------------------AK--------------------- HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK -------------------------------------L---------------------- HIPK2_Hsap_HIPK -------------------------------------V---------------------- HIPK1_Hsap_HIPK -------------------------------------V---------------------- smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 -------------------------------------A---------------------- Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 -------------------------------------AK--------------------- HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK -------------------------------------V---------------------- HIPK2_Mmus_HIPK -------------------------------------V---------------------- HIPK1_Mmus_HIPK -------------------------------------V---------------------- DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 -------------------------------------L---------------------- DYRK1A_Mmus_DYRK1 -------------------------------------M---------------------- mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 -------------------------------------LI--------------------- C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 -------------------------------------L---------------------- DYRK1A_Hsap_DYRK1 -------------------------------------M---------------------- YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ----------------------------------TTPT---------------------- Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 -------------------------------------I---------------------- 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 -------------------------------------A---------------------- DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 --------------------------------------R--------------------- CG7028_Dmel_PRP4 -------------------------------------SR--------------------- CC1G_13957_Ccin_DYRK2 HRFSALSPSKGLKLLGPKSSRSAASSSQNLRQNMSSPSSSRQSLSTPSPVPSTVDEDELL CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 -------------------------------------L---------------------- AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 -------------------------------------Y---------------------- GK033_Glam_DYRK2 -------------------------------------E---------------------- GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------SRSLERKRRE-PER---------- HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK -----------------------------------K--NTA------------------- HIPK2_Hsap_HIPK -----------------------------------TSASST------------------- HIPK1_Hsap_HIPK -----------------------------------TAADSS------------------- smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 -----------------------------------M---QA------------------- Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK -------------------------------------AST-------------------- PRP4_Mmus_PRP4 ------------------------------------SRSLERKRRE-PER---------- HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK -----------------------------------K--DTA------------------- HIPK2_Mmus_HIPK -----------------------------------TSASST------------------- HIPK1_Mmus_HIPK -----------------------------------TAADSS------------------- DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 -----------------------------------L---PR------------------- DYRK1A_Mmus_DYRK1 -----------------------------------L---QR------------------- mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK -------------------------------------LTT-------------------- F22D6.5_Cele_PRP4 ------------------------------------QRKREDNRRD-PR----------- C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 -----------------------------------L---PR------------------- DYRK1A_Hsap_DYRK1 -----------------------------------L---QR------------------- YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 -----------------------------------K---SS------------------- Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ---------------------------------------------------TRQNGTPYV 5356_Tthe_DYRK2 -----------------------------------I---PQSNKIEQISNRYNLTSTNKP 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 -----------------------------------------------SNRDRESRRSEEN DYRK1_Spur_DYRK1 -----------------------------------M---QS------------------- DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------SRPSPP-RRSPP------------ CG7028_Dmel_PRP4 ------------------------------------NRNMEDLRQE-INRDKQRERRDHS CC1G_13957_Ccin_DYRK2 GDEEMMNYIRRQQAKKKAAGATQEELEEMLKFPEPT---PP------------------- CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 -----------------------------------I---PRL------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 -----------------------------------I---KS------------------- GK033_Glam_DYRK2 -----------------------------------L---KR------------------- GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 -----RRL----------SSPRTRPRDDILSRRERSKDASPINRWSPTR--RRSRSPIRR HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 -----RRL----------SSPRTRPRDDILGRCERSKDASPINRWSPTR--RRSRSPIRR HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ----------------------------------------------------PSK----- DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------RASKTM mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ----------------------------------------------------LLK----- DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------Y----- YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 KKDLTIKTGNSIETLKDILSPTNNNANPKTTTATKDSKKHLNSNTLPIQSYT-------- 5356_Tthe_DYRK2 NSRMHLMIGTENDQSQNQMGGLKDFLSPQGAAFIKSNVSSKSTQRNYSNKNR-------- 5655_Tthe_DYRK2 --------------------------------------------QELQLNYN-------- 15575_Tthe_PRP4 NTRESKQLTLEEEEERNDRY---YNDFDDS------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------PR-------RPPSPPARR CG7028_Dmel_PRP4 RDRDRR----------------------------------GLDRPPPPTDMRPGRARE-- CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ---------------------------------------------------KPS------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ---------------------------------------------------RHAY----- PRP4_a_Smoe_PRP4 ---------------------------------------------------RHAY----- PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ---------------RSR------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK -----------------GATKVIAAQA--------QQ----------------------- HIPK2_Hsap_HIPK ------------------S-------V--------TG----------------------- HIPK1_Hsap_HIPK -----------------GS-------A--------AT----------------------- smi35A_Dmel_DYRK2 ----------------------------------------------------------TT mnb_Dmel_DYRK1 --------------------------R--------IP----------------------- Dyrk3_Dmel_DYRK2 -----------------------------------------------------------I CG17090_Dmel_HIPK -------------------SSVAAAA---------------------------------- PRP4_Mmus_PRP4 ---------------RSR------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK -----------------GATKVLAAQA--------QQ----------------------- HIPK2_Mmus_HIPK ------------------S-------V--------TG----------------------- HIPK1_Mmus_HIPK -----------------GS-------A--------AT----------------------- DYRK4_Mmus_DYRK2 --------------------------------------------------------GPMQ DYRK3_Mmus_DYRK2 -----------------------------------------------------------T DYRK2_Mmus_DYRK2 -----------------------------------------------------------T DYRK1B_Mmus_DYRK1 --------------------------R--------LP----------------------- DYRK1A_Mmus_DYRK1 --------------------------R--------MP----------------------- mbk-2_Cele_DYRK2 I---------------------------------------DVLAPV---------RDTVA mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK -------------------SSTFA------------------------------------ F22D6.5_Cele_PRP4 -----------------AHEGNRRRDR--------------------------------- C36B7.2_Cele_DYRK2 -----------------CV----------------------------------------- C36B7.1_Cele_DYRK2 -----------------GV----------------------------------------- DYRK4_Hsap_DYRK2 --------------------------------------------------------SSLL DYRK3_Hsap_DYRK2 -----------------------------------------------------------T DYRK2_Hsap_DYRK2 -----------------------------------------------------------T DYRK1B_Hsap_DYRK1 --------------------------R--------LP----------------------- DYRK1A_Hsap_DYRK1 --------------------------R--------MP----------------------- YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 --------------------------C--------TI----------------------- Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------TTHAQQ 5356_Tthe_DYRK2 YLGLNKIQAQQQNSSQSR-----------------VRSNIKQMSKDKALSVDKTSNYINR 5655_Tthe_DYRK2 NNNI------------------------------------------------KNGKKISR 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 --------------------------R--------IP----------------------- DYRK2_Spur_DYRK2 -----------------------------------------------------------K DYRK4_Spur_DYRK2 --------------------------------------------------------GHLV HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 PDQPLGRRGRSPIERRGR------------------------------------------ CG7028_Dmel_PRP4 ---------------RDV------------------------------------------ CC1G_13957_Ccin_DYRK2 --------------------------V--------PP----------------------- CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 --------------------------------------------------------GSCR AqueK113_Aque_DYRK2 -----------------------------------------------------------Q AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 -----------------------------------------------------------V DYRK2_a_Smoe_DYRK2 -----------------------------------------------------------V DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 --------------------------K--------PP----------------------- GK033_Glam_DYRK2 --------------------------RIIRLLTQRV------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ---NSSNGG--------------------------------------------------- mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ---SLPNVTSPSK----------------------------------------------- CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ---YQENQI--------------------------------------------------- DYRK3_Mmus_DYRK2 ---LQSDGISNSE----------------------------------------------- DYRK2_Mmus_DYRK2 ---TQPNGLTTVG----------------------------------------------- DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ---AQATGLPNVGTSSSN------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 --------------------------------------------------------DQ-- C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ---YQENQA--------------------------------------------------- DYRK3_Hsap_DYRK2 ---IQSDGISDSE----------------------------------------------- DYRK2_Hsap_DYRK2 ---TQPNGLTTVG----------------------------------------------- DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP --------------------------------------------------------NN-- 22423_Tthe_DyrkP --------------------------------------------------------NNG- 5306_Tthe_DYRK2 IHQQKRLLQKR--D--DQKNKSNFINSSFQYIMASENNSVENTNRFSYNVMNNMVANN-- 5356_Tthe_DYRK2 ----------RDSTQNQ------------------------------------------- 5655_Tthe_DYRK2 YGEEYSK--RQ--SFQMN------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ---VIANGHLSHD----------------------------------------------- DYRK4_Spur_DYRK2 ASGIHQTTI--------------------------------------------------- HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 RSPSKQTTA--------------------------------------------------- AqueK113_Aque_DYRK2 ---ST------------------------------------------------------- AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ---Y-------------------------------------------------------- DYRK2_a_Smoe_DYRK2 ---Y-------------------------------------------------------- DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP --------------------------------------------------------NGDA PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ----------------------------------------------------STTNSR-- GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------SEHMPLYP----------------QQLQMN 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP DVDALCGAADELSFRPHANDYDGQLLDSEELKQIRSEPAWQGFVVQGNAIRKDQAATT-- PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ----------------------------------------------------------GP PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP SPH------NNQSDLNQKSEKQTEE---------------LKET---------------- 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------ANDQDDFSREIRE---------------TYLAESSDGEVGSLQDCDFQ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 TPFSYFYDRTLK-----------VDSNCERVGYTMYPACSDYWV---------------- PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP --------QNKL--------------------------------------EQLQNQDV-Q 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP GRNGFLDVEKRRQ--QCFKQGGPSSAEEEHDIVLQYYNRPWGHKAQANGCEEVDRNGSVE PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 --------KHRHSGNDALGNESTDEYSQPDDPGRIVYTYDYDNDNILNSTFEIELHSFA- PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ADAQNDLLQGILLQEDFMPNIDEYTDDDDPGFDLYEVPQKDFVRVAQQLAEK-------- 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP T----------------------------------------------QLAEEQLGAFQFG PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 -----------------------------------------------QVMQEMG------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP -SDFPARAVSSIPK------------KEG-------------------------YDPH-- 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP GFSFPS------PS----SAGDVDGSRAESGRSLWSTREISSRGEEVDQFANGFVGPDDT PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 --SNPLGTDDLLPVEKPAV----------------------------------------- PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------TVY--------------------------------------- C36B7.1_Cele_DYRK2 ------------------SQQ--------------------------------------- DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------NNN--------------------------------------- 22423_Tthe_DyrkP ----K---EYSNPFA---NAN--------------------------------------- 5306_Tthe_DYRK2 --------------------QGQKLLKNKNNSMEN------QQFKNLSFTQPLNDQFK-- 5356_Tthe_DYRK2 ----------------------------------NGNYIQDKSSLLQTLQPPASQSYDQG 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP LASWKRKSNESSPII---SGG--------------------------------------- PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------TTT--------------------------------------- GK033_Glam_DYRK2 --------------------A--------------------------------------- GK032_Glam_DYRK2 --------ALGDQYTTVTPTS--------------------------------------- PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 --------------------------------------------------GSS--NSS-- mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 --------------QTKENNN-----------------TQNSNNKILTVKQ-QQQK-QQL 5356_Tthe_DYRK2 GDNAYYKHNTLQDEQ---------------------------LGSTYYTID-NQN----- 5655_Tthe_DYRK2 --------------------GGKQMYCHNEQLQIDKCETINIPS-HIYSKS-T--NHS-- 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ----SGVGSGGSG------SL--------------------------------------- mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 QFIQKGLG--QNSSKQNQSSIQTSEGNENKSESNYESQGQNLDNFDQHKIDLSTASQTP- 5356_Tthe_DYRK2 ------------------------------------------------------LQQPTI 5655_Tthe_DYRK2 ----ASKG--TKSP----FQIN----------------------------------PTPT 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 -----------------------------------------SPLR----R---------- HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 --------------------------------------NERG------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 --------------------------------------TKDV------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 -----------------------------------------SPLR----R---------- HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 --------------------------------------HNQV------------------ DYRK3_Mmus_DYRK2 ---------------------------------------KSS------------------ DYRK2_Mmus_DYRK2 --------------------------------------KTGL------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 --MTQSIGGPNKHLSASHS-----TLNTASTH---DMMHSKI------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 -----------------------------------------TPER----F---------- C36B7.2_Cele_DYRK2 ---------PN------------------------------------------------- C36B7.1_Cele_DYRK2 ---------DE------------------------------------------------- DYRK4_Hsap_DYRK2 --------------------------------------HNQM------------------ DYRK3_Hsap_DYRK2 ---------------------------------------KCS------------------ DYRK2_Hsap_DYRK2 --------------------------------------KTGL------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 -----------------------------------------EKQA----DRKDEVRVKDN YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ---------PG------------------------------------------------- 22423_Tthe_DyrkP ---------PN------------------------------------------------- 5306_Tthe_DYRK2 -FRNGNST---------------------------------------------------- 5356_Tthe_DYRK2 Q--SSGSSK--------------------------------------------------- 5655_Tthe_DYRK2 NSNNNNSKKPKLSLNSVHLNNRASS------FSVEDEN---------------------- 15575_Tthe_PRP4 ------------------------------------------DS---------------D DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 --------------------------------------ANAL------------------ DYRK4_Spur_DYRK2 --------------------------------------GEHI------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 -----------------------------------------SPLERRIRS---------- CG7028_Dmel_PRP4 -----------------------------------------RPSR----M---------- CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 --------------------------------------GASV------------------ AqueK113_Aque_DYRK2 --------------------------------------ADTL------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ---------ED------------------------------------------------- PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 -----------------------------------------SPDR----R------RRSR PRP4_a_Smoe_PRP4 -----------------------------------------SPDR----R------RRSR PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ---------PK------------------------------------------------- GK033_Glam_DYRK2 ---------PE------------------------------------------------- GK032_Glam_DYRK2 ---------PQ------------------------------------------------- PRP4_Hsap_PRP4 --------------S-------RSPRRRSR--------------SPRRRDRGRRSR---- HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 -------------------------------S----------ST--KSNS------S--- mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------PGLFLRTI----------SENSKSKS------E--- CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 --------------S-------RSPRRRSR--------------SPRRRDRSRRSR---- HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 -------------------------------L----------SS--ELKT------SE-- DYRK3_Mmus_DYRK2 ------------------------P-------------------ASQGKS------S--- DYRK2_Mmus_DYRK2 ------------------------PGVPERQL------------ESIHRR------Q--- DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------PKSPSNE--------------SLSRSH-----T--- mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 --------------R----------NNR-DRRDRDGRREDRHRRSP-------------- C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 -------------------------------P----------AS--ELKA------SE-- DYRK3_Hsap_DYRK2 ------------------------PT------------------VSQGKS------S--- DYRK2_Hsap_DYRK2 ------------------------PVVPERQL------------DSIHRR------Q--- DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ISVNDDKTNHGEN----------------------------------------------- YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ----------------------------------------------------QVKFMKNV 15575_Tthe_PRP4 YYQRVNDRKYKSSR-----------------------------------------RSKSR DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------PD--------------------VKR-------P--- DYRK4_Spur_DYRK2 --------------------------------KAHR------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 --------------SRSPAVVDRFDRRRGA--------------SPPRRFGDMSRN---- CG7028_Dmel_PRP4 ------------------------QRSHSR--------------SKFESDR---RR---- CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 -------------------------------PDPHSRGRLYRST--SLRSDSDLDGDSLP AqueK113_Aque_DYRK2 ------------------------PNLHHNRP------------LTSAQ-------P--- AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 SREHDEREKYPRKRA----------------------------------------E---- PRP4_a_Smoe_PRP4 SREHDEREKYPRKRA----------------------------------------E---- PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 -----------------SR----LRRRSRS---RGGRRRRSR---SKVKEDKFKGSLSEG HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 -------SG-SGSS---------------------GNSAS-------------------- mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 -------PEC-ESLISVKESSVMENHTFLFHEQIIMSGQQ-------------------- CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 -----------------SR----LRRRSRS---RGGHRRRSR---SKVKEDKFKGSLSEG HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------IPFNINTK---------------------AQDTK-------------------- DYRK3_Mmus_DYRK2 -----------ESL----------------------SAVK-------------------- DYRK2_Mmus_DYRK2 -----------GSS----------------------TSLK-------------------- DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 -----------SSS----------------------GGSQ-------------------- mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 -----------------DR----RRDSDRK---REDGK---------------------- C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------IPFHPSIK---------------------TQDPK-------------------- DYRK3_Hsap_DYRK2 -----------DCL----------------------NTVK-------------------- DYRK2_Hsap_DYRK2 -----------GSS----------------------TSLK-------------------- DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 -------------------------------------------------LTN-------E YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------NEKKTLDDNNTRNTERDE--------KK-------------------- 5356_Tthe_DYRK2 --------------------------------------LE-------------------- 5655_Tthe_DYRK2 ESFTNQQQTKLKSLRQILNDTT-------DQRQNTHASVI-------------------- 15575_Tthe_PRP4 SKNRDRKKSKSKGRKDD-KNKDKDKERSKN-SGNGDNSKSSKDK-KEEE----------- DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 -----------AS-------------------------DG-------------------- DYRK4_Spur_DYRK2 ------QPNKF------------------------EEIKR-------------------- HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 -----------------RR----RWSRSPDRRGRRGRWGRSR---SKSPRDKFKGSLSEG CG7028_Dmel_PRP4 -----------------ER----ERQKDRD---RGGGRVGARSGTDNGDRDRYKGSLSEG CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 IPGIGGVPAAV------------------------PSTSR-------------------- AqueK113_Aque_DYRK2 -----------QSM----------------------TDDA-------------------- AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 --SRDRHIKDDRGARDDER----HYNRDR-------------SR---------------- PRP4_a_Smoe_PRP4 --SRDRHIKDDRGARDDER----HYNRDR-------------NRRDREELSEKQETTQSE PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 M-KVEQESSSDDNL--EDFDV--E----EEDEEALI------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 M-KVEQESSSDDNL--EDFDV--E----EEDEEALI------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 -----------------------------------KTNSHAFYPQQEVTQVRPK------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ---RKDESK--DVE--WNLDS--D----SDDEQKKI------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ---------------------------------------------QFGSRFVPSLYD--- Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 SITAT---STNEPT--KPAVI-IE-EDEETKTKRIL------------------------ YakA_Ddis_YAK ------------------------------------------------H-KTHK------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 AKKAQQPETIDDD---EDLNMEI----EDSD----------------------------- DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 L-SLKQESS-DDEI--PDVDL-DE----EEDEEAVI------------------------ CG7028_Dmel_PRP4 QNKLDKESSDEEVN--VNIDI-LE----EDDEERII------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------FEL-AKDGEDDAKRGEII--------------------ANAA CC1G_14245_Ccin_YAK ----------------------------------------------VGY-QSPS------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 --------------------L-MS----EDEVKEIK------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 --------------------------------ERVR------------------------ PRP4_d_Smoe_PRP4 --------------------------------ERVR------------------------ PRP4_b_Smoe_PRP4 -------QNQDEYLERVAHQL-AE-Q--EEDIEKVK------------------------ PRP4_a_Smoe_PRP4 TIEREE-ENQDEYLERVAHQL-AE-Q--EEDIEKVK------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------EQRR-------I------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------EQRR-------I------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 -----------------------KHRVSM------------------------------- hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------EAAR-------K------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------RQDF-------Q---------------------------RRQSLA--A Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------EENR-------L------------------------------------ YakA_Ddis_YAK -----------------------K-TASIGG----GKN----RAILHDFT---------- 22349_Tthe_YAK -----------------------Q-SDYIM------RV----KDIIY------------- 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------DERE-------R------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------ERRR-------R------------------------------------ CG7028_Dmel_PRP4 ------------ELRR-------K------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 EPAGGDQINAADYDPSLDRREDER------------------------------------ CC1G_14245_Ccin_YAK -----------------------M-TGNVSSGTTAGSTSDSYSDLYYNGSASQPPKRIQD AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------EESR-------K------------------------------------ PRP4_d_Smoe_PRP4 ------------EESR-------K------------------------------------ PRP4_b_Smoe_PRP4 ------------EESR-------K------------------------------------ PRP4_a_Smoe_PRP4 ------------EESR-------K------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------STGSG------------------------------------------- mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------KCELH------------------------------------------- CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------PHPEL------------------------------------------- DYRK3_Mmus_DYRK2 ------------CNLSS------------------------------------------- DYRK2_Mmus_DYRK2 ------------SMEGM------------------------------------------- DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------GGHNS------------------------------------------- mbk-1_Cele_DYRK1 -------------------------------------TNAEAALTPGMPPEKQAAKK--R hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------AEEKS------------------------------------------- DYRK3_Hsap_DYRK2 ------------SNSSS------------------------------------------- DYRK2_Hsap_DYRK2 ------------SMEGM------------------------------------------- DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK TNYSSNFS-SLNSNTNQGTNSIPVMSPYR-RLSAYPPSTS--------PPLQPPFKQL-- Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------F---------------SYFIPNQ-N----------------------------R 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------EEPLD------------------------------------------- 5356_Tthe_DYRK2 ------------EKHLT------------------------------------------- 5655_Tthe_DYRK2 ------------STNND------------------------------------------- 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------SKNGS------------------------------------------- DYRK4_Spur_DYRK2 ------------SSKNE------------------------------------------- HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK PNRAAG-RSPHRAAN--PTNSTGLIDAYAQQQSQYSPTTATYSYGPG-PPQSTGYQTHGR AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------SRRNP------------------------------------------- AqueK113_Aque_DYRK2 ------------SSDQS------------------------------------------- AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------ELKC--N--T-------------------- mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------EKPK--V--L-------------------- CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------QKKH--K--V-------------------- DYRK3_Mmus_DYRK2 ------------------------------RPSK--V--L-------------------- DYRK2_Mmus_DYRK2 ------------------------------GKVK--A--S-------------------- DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------NSGS--N--S-------------------- mbk-1_Cele_DYRK1 NIG------QFSTDTVPAGIGMIGIPFESTSKP---L--Q-------------------- hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ---------------------------------E--N--P-------------------- C36B7.1_Cele_DYRK2 ---------------------------------A--C--S-------------------- DYRK4_Hsap_DYRK2 ------------------------------PKKQ--K--V-------------------- DYRK3_Hsap_DYRK2 ------------------------------KAPK--V--V-------------------- DYRK2_Hsap_DYRK2 ------------------------------GKVK--A--T-------------------- DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK R-RDEVQGQKLSIPQMQLCNSKNDLQPVLNATPK--F--R-------------------- Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK S-EDNSNENELGLN---------------------------------------------- 22349_Tthe_YAK --NDQ-RKMFLIKE---------------------------------------------- 10580_Tthe_DyrkP ---------------------------------Q--N--Q------GN-ES--------T 22423_Tthe_DyrkP ---------------------------------Q--EDSQAMIKDIQK-QS--------S 5306_Tthe_DYRK2 ------------------------------WEKV--K--V-------------------- 5356_Tthe_DYRK2 ------------------------------WEDL--K--L-------------------- 5655_Tthe_DYRK2 ------------------------------QLI---L--N-------------------- 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------AKGR--A--L-------------------- DYRK4_Spur_DYRK2 ------------------------------GKDS--R--G-------------------- HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK S-NSQVKQE-------------------QATPPI--A--S-------------------- AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------QQSI--R--L-------------------- AqueK113_Aque_DYRK2 ------------------------------QSQK--Q--R-------------------- AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------YSTW--L--N-------------------- DYRK2_a_Smoe_DYRK2 ------------------------------YSTW--L--N-------------------- DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ---------------------------------HELRLALSTHSTVSP-GS--------T PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ---------------------------------R------------GASTSTRSERTAST GK033_Glam_DYRK2 ---------------------------------A------------DVTVKLLDVLGSFK GK032_Glam_DYRK2 ---------------------------------A-----H------GDNTI--------A PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ----------------P---------M--------------------------------- mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ----------------V---------V--------------------------------- CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ----------------P---------L--------------------------------- DYRK3_Mmus_DYRK2 ----------------P---------L--------------------------------- DYRK2_Mmus_DYRK2 ----------------P---------M--------------------------------- DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ----------------G---------F--------------------------------- mbk-1_Cele_DYRK1 ----------------I---------Q--------------------------------- hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ----------------G---------L--------------------------------- C36B7.1_Cele_DYRK2 ----------------G---------L--------------------------------- DYRK4_Hsap_DYRK2 ----------------T---------L--------------------------------- DYRK3_Hsap_DYRK2 ----------------P---------L--------------------------------- DYRK2_Hsap_DYRK2 ----------------P---------M--------------------------------- DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ----------------R---------A--------------------------------- Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP -------EQNISNADQD---------LLSRRSN------------------NQAKGYI-- 22423_Tthe_DyrkP -------SQAVDDQQQQ---------KIVQQKN------------------QVSKASI-- 5306_Tthe_DYRK2 ----------------P---------I--------------------------------- 5356_Tthe_DYRK2 ----------------P---------V--------------------------------- 5655_Tthe_DYRK2 ----------------T---------E--------------------------------- 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ----------------P---------M--------------------------------- DYRK4_Spur_DYRK2 ----------------H---------M--------------------------------- HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ----------------P---------Y--------------------------------- AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ----------------P---------M--------------------------------- AqueK113_Aque_DYRK2 ----------------Y---------L--------------------------------- AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ----------------C---------F--------------------------------- DYRK2_a_Smoe_DYRK2 ----------------C---------F--------------------------------- DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP EDSLSVEEERVDDEDVD------------AQRD------------------ETEAAAA-- PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ----------------SVSPRAVATKLSQRTPSSKGRGVVAATTTPADQNRSQLKGSA-- GK033_Glam_DYRK2 ----------------GLVESVPTDDGVPLWTFDWGSAVYFSEHNIGSAASDLNARYI-- GK032_Glam_DYRK2 -------EVEFTADDEG---------AMDNSTD------------------EQAPGYVPV PRP4_Hsap_PRP4 --------------------------------------------------------QR-- HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ----------------------------------A-----------------HVQAP--- HIPK2_Hsap_HIPK ----------------------------------Q-----------------VLGGP--- HIPK1_Hsap_HIPK ----------------------------------S-----------------TFQSS--- smi35A_Dmel_DYRK2 ------------------------------T----------------------PSELV-- mnb_Dmel_DYRK1 ----------------------------------N-----------------HFREPA-- Dyrk3_Dmel_DYRK2 ------------------------------S----------------------PQQVM-- CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 --------------------------------------------------------QR-- HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ----------------------------------A-----------------GVEAP--- HIPK2_Mmus_HIPK ----------------------------------Q-----------------VLGGP--- HIPK1_Mmus_HIPK ----------------------------------A-----------------TFQSS--- DYRK4_Mmus_DYRK2 ------------------------------T----------------------VAEAL-- DYRK3_Mmus_DYRK2 ------------------------------T----------------------PEQAL-- DYRK2_Mmus_DYRK2 ------------------------------T----------------------PEQAM-- DYRK1B_Mmus_DYRK1 ----------------------------------L-----------------AFRDAA-- DYRK1A_Mmus_DYRK1 ----------------------------------Q-----------------TFRDPA-- mbk-2_Cele_DYRK2 ------------------------------R----------------------PEDAV-- mbk-1_Cele_DYRK1 ----------------------------------------------------QFRNPQ-- hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 --------------------------------------------------------RR-- C36B7.2_Cele_DYRK2 ------------------------------S----------------------PSSIF-- C36B7.1_Cele_DYRK2 ------------------------------I----------------------PQQAS-- DYRK4_Hsap_DYRK2 ------------------------------T----------------------AAEAL-- DYRK3_Hsap_DYRK2 ------------------------------T----------------------PEQAL-- DYRK2_Hsap_DYRK2 ------------------------------T----------------------PEQAM-- DYRK1B_Hsap_DYRK1 ----------------------------------L-----------------AFRDAT-- DYRK1A_Hsap_DYRK1 ----------------------------------Q-----------------TFRDPA-- YAK1_Scer_YAK ----------------------------------------------------SLNSKT-- Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ----------------------------------I-----------------TPSIAL-- Prp4_Ddis_PRP4 --------------------------------------------------------QR-- YakA_Ddis_YAK ----------------------------------------------------NHNVQH-- 22349_Tthe_YAK ----------------------------------------------------KFEIQK-- 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------T----------------------PLEVL-- 5356_Tthe_DYRK2 ------------------------------G----------------------PDDVL-- 5655_Tthe_DYRK2 ------------------------------N----------------------TNNIL-- 15575_Tthe_PRP4 --------------------------------------------------------KK-- DYRK1_Spur_DYRK1 ----------------------------------H-----------------TFRDAT-- DYRK2_Spur_DYRK2 ------------------------------T----------------------PEESM-- DYRK4_Spur_DYRK2 ------------------------------K----------------------PNEAM-- HIPKa_Spur_HIPK ----------------------------------V-----------------GPHRP--- HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 --------------------------------------------------------ER-- CG7028_Dmel_PRP4 --------------------------------------------------------KR-- CC1G_13957_Ccin_DYRK2 ----------------------------------A-----------------SPHHVL-- CC1G_04865_Ccin_PRP4 --------------------------------------------------------KRFG CC1G_14245_Ccin_YAK ----------------------------------------------------APQNQS-- AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 -------------------------------------------------------QQH-- AqueK112_Aque_DYRK2 ------------------------------T----------------------PSQAI-- AqueK113_Aque_DYRK2 ------------------------------T----------------------PDQAI-- AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------V----------------------RSAVL-- DYRK2_a_Smoe_DYRK2 ------------------------------V----------------------RSAVL-- DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 --------------------------------------------------------RR-- PRP4_d_Smoe_PRP4 --------------------------------------------------------RR-- PRP4_b_Smoe_PRP4 --------------------------------------------------------RR-- PRP4_a_Smoe_PRP4 --------------------------------------------------------RR-- PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------FPREI-----------------TAAEVL-- GK033_Glam_DYRK2 ------------------------------RPQSKAISKRAGSRIITMRAQPSAESPD-- GK032_Glam_DYRK2 GDNMDPGLIDQQVLHNAEAPGLNREKAPEHM----------------------PEAAF-- PRP4_Hsap_PRP4 Q--------------------------------------------AIV--QKYK------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK QI-GAW-R------------------------------N-R---LHFL--EGPQRCG--- HIPK2_Hsap_HIPK HN-LMR-R------------------------------S-T---VSLL--DTYQKCG--- HIPK1_Hsap_HIPK QT-LTH-R------------------------------S-N---VSLL--EPYQKCG--- smi35A_Dmel_DYRK2 KKF-RN-Y------------------------------L-TDLEFEEL--KVYK---EVW mnb_Dmel_DYRK1 SG-PLR-K------------------------------L-S---VDLI--KTYKHINEVY Dyrk3_Dmel_DYRK2 ILY-MN-K------------------------------L-TPYERTEI--LTYP---QIY CG17090_Dmel_HIPK --------------------------------------------------------T--- PRP4_Mmus_PRP4 Q--------------------------------------------AIV--QKYK------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK RA-VVW-R------------------------------N-R---LHFL--EGPQRCG--- HIPK2_Mmus_HIPK HN-LMR-R------------------------------S-T---VSLL--DTYQKCG--- HIPK1_Mmus_HIPK QT-LTH-R------------------------------S-N---VSLL--EPYQKCG--- DYRK4_Mmus_DYRK2 KFF-KN-Q------------------------------L-SPYEQSEI--LGYS---ELW DYRK3_Mmus_DYRK2 KQY-KH-H------------------------------L-TAYEKLEI--VSYP---EIY DYRK2_Mmus_DYRK2 KQY-MQ-K------------------------------L-TAFEHHEI--FSYP---EIY DYRK1B_Mmus_DYRK1 SA-PLR-K------------------------------L-S---VDLI--KTYKHINEVY DYRK1A_Mmus_DYRK1 TA-PLR-K------------------------------L-S---VDLI--KTYKHINEVY mbk-2_Cele_DYRK2 QTF-GA-K------------------------------L-VPFEKNEI--YNYT---RVF mbk-1_Cele_DYRK1 DA-PVR-K------------------------------L-T---SDLI--KTYKAINESF hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 I--------------------------------------------QII--KKIE------ C36B7.2_Cele_DYRK2 NGY-SH-L------------------------------L-SPFEKIEV--KKYG---KIY C36B7.1_Cele_DYRK2 LVY-LH-Q------------------------------L-TSYEKREI--EDYP---IVY DYRK4_Hsap_DYRK2 KLF-KN-Q------------------------------L-SPYEQSEI--LGYA---ELW DYRK3_Hsap_DYRK2 KQY-KH-H------------------------------L-TAYEKLEI--INYP---EIY DYRK2_Hsap_DYRK2 KQY-MQ-K------------------------------L-TAFEHHEI--FSYP---EIY DYRK1B_Hsap_DYRK1 SA-PLR-K------------------------------L-S---VDLI--KTYKHINEVY DYRK1A_Hsap_DYRK1 TA-PLR-K------------------------------L-S---VDLI--KTYKHINEVY YAK1_Scer_YAK IS-PLV-S------------------------------V-T---KSLI--TTYSLCSPEF Dyrk1_Ddis_DYRK1 ----------------------------------------------LI--KTYKHINQVY Dyrk2_Ddis_DYRK2 KLY-IN-D------------------------------L-TSAEQSEI--LDY---PQIY Prp4_Ddis_PRP4 Q--------------------------------------------LIM--EKYN------ YakA_Ddis_YAK QG-PII-H------------------------------L-T---KNLL--HFYKKCNSNF 22349_Tthe_YAK QQ-IKI-E------------------------------LNA---LFCI--KLLRNVELIP 10580_Tthe_DyrkP ----------------YLPK-FLKH----PPSNDEFYPV------------QLD---KAI 22423_Tthe_DyrkP ----------------FLPD-HIKF----PQSNDSFYPI------------KYD---KVI 5306_Tthe_DYRK2 AKY-QK-Y------------------------------L-TPQEKAEI--LEFK---RIY 5356_Tthe_DYRK2 NKY-GHEF------------------------------L-TDYEKKEI--LQYM---NIY 5655_Tthe_DYRK2 TQS-KE-N------------------------------L-NIDINSEI--KDWA--LVIY 15575_Tthe_PRP4 Q--------------------------------------------EFL--NMIK------ DYRK1_Spur_DYRK1 HA-PLR-K------------------------------L-S---IDLI--KTYKHINEVY DYRK2_Spur_DYRK2 KLY-MH-K------------------------------L-TSYEHHEI--FNYP---HIY DYRK4_Spur_DYRK2 MYY-RD-K------------------------------L-TVFEEAEI--LDYQ---EVW HIPKa_Spur_HIPK QN-VIQ-A------------------------------S-T---VRLL--DTYQKCG--- HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 Q--------------------------------------------QLM--QKYK------ CG7028_Dmel_PRP4 E--------------------------------------------ELL--KKLG------ CC1G_13957_Ccin_DYRK2 KSSQAQ-Y------------------------------L-SDYERKEI--LDY---PSVY CC1G_04865_Ccin_PRP4 V--------------------------------------------DQAANGTNH------ CC1G_14245_Ccin_YAK HQ-PLR-Q------------------------------L-T---TNIV--ETYRICNPSY AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 VS-VVK-K------------------------------L-T---VDLI--KTYRTINEVY AqueK112_Aque_DYRK2 KEY-GH-R------------------------------L-TGYEKKEI--LEYP---DVW AqueK113_Aque_DYRK2 KLY-GS-K------------------------------L-SEFEQQEI--QAFQ---QVY AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 KQY-PS-S------------------------------L-TDFEKQEI--LKYP---EIY DYRK2_a_Smoe_DYRK2 KQY-PS-S------------------------------L-TDFEKQEI--LKYP---EIY DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ----------------YDEE-AIA-------VHEHFHRL------------QAE---EEE PRP4_e_Smoe_PRP4 Q--------------------------------------------AIL--EKHA------ PRP4_d_Smoe_PRP4 Q--------------------------------------------AIL--EKHA------ PRP4_b_Smoe_PRP4 Q--------------------------------------------AIL--EKHK------ PRP4_a_Smoe_PRP4 Q--------------------------------------------AIL--EKHK------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK --------------------------------------------KFIV--ETYRSCNPSF YAK_a_Smoe_YAK --------------------------------------------KFIV--ETYRSCNPSF YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ---------------------------------------------------TYR---GIH GK034_Glam_DYRK2 SSH-KS-D------------------------------L-TPFEQSEI--QRF---AKIY GK033_Glam_DYRK2 PG-PEQ-Q------------------------------Y-------VV--ERSSHYPNVF GK032_Glam_DYRK2 KSH-IA-KKIEETERAVTPYVVRKQSAIRHRDKDRQYIV------------TGD---TMR PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ---LKRK----------------------------------------------------- HIPK2_Hsap_HIPK ---LKRK----------------------------------------------------- HIPK1_Hsap_HIPK ---LKRK----------------------------------------------------- smi35A_Dmel_DYRK2 YFGQHAS----------------------------------------------------- mnb_Dmel_DYRK1 YAKKKRR----------------------------------------------------- Dyrk3_Dmel_DYRK2 FIGANAK----------------------------------------------------- CG17090_Dmel_HIPK ---SKRK----------------------------------------------------- PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ---LKRK----------------------------------------------------- HIPK2_Mmus_HIPK ---LKRK----------------------------------------------------- HIPK1_Mmus_HIPK ---LKRK----------------------------------------------------- DYRK4_Mmus_DYRK2 FLGLEAK----------------------------------------------------- DYRK3_Mmus_DYRK2 FVGPNAK----------------------------------------------------- DYRK2_Mmus_DYRK2 FLGPNAK----------------------------------------------------- DYRK1B_Mmus_DYRK1 YAKKKRR----------------------------------------------------- DYRK1A_Mmus_DYRK1 YAKKKRR----------------------------------------------------- mbk-2_Cele_DYRK2 FVGSHAK----------------------------------------------------- mbk-1_Cele_DYRK1 YLRKQVR----------------------------------------------------- hpk-1_Cele_HIPK -----RA----------------------------------------------------- F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ALSMN------------------------------------------------------- C36B7.1_Cele_DYRK2 TVGDY------------------------------------------------------- DYRK4_Hsap_DYRK2 FLGLEAK----------------------------------------------------- DYRK3_Hsap_DYRK2 FVGPNAK----------------------------------------------------- DYRK2_Hsap_DYRK2 FLGLNAK----------------------------------------------------- DYRK1B_Hsap_DYRK1 YAKKKRR----------------------------------------------------- DYRK1A_Hsap_DYRK1 YAKKKRR----------------------------------------------------- YAK1_Scer_YAK TYQ--------------------------------------------------------- Dyrk1_Ddis_DYRK1 YTAKAKK----------------------------------------------------- Dyrk2_Ddis_DYRK2 FTGNTNK----------------------------------------------------- Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK NYI--------------------------------------------------------- 22349_Tthe_YAK YKEKKHA----------------------------------------------------- 10580_Tthe_DyrkP YDCF-------------------------------------------------------- 22423_Tthe_DyrkP YDAF-------------------------------------------------------- 5306_Tthe_DYRK2 FIGHNAN----------------------------------------------------- 5356_Tthe_DYRK2 YVGHKAK----------------------------------------------------- 5655_Tthe_DYRK2 FIGHQCK----------------------------------------------------- 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 YAKKKRR----------------------------------------------------- DYRK2_Spur_DYRK2 FTGPNAK----------------------------------------------------- DYRK4_Spur_DYRK2 FLGPEAK----------------------------------------------------- HIPKa_Spur_HIPK ---LKRK----------------------------------------------------- HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 FIGAKSR----------------------------------------------------- CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK RYE--------------------------------------------------------- AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 YKKRRIS----------------------------------------------------- AqueK112_Aque_DYRK2 FLGLESK----------------------------------------------------- AqueK113_Aque_DYRK2 FVGQHAK----------------------------------------------------- AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 YIGLPQK----------------------------------------------------- DYRK2_a_Smoe_DYRK2 YIGLPQK----------------------------------------------------- DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP FETF-------------------------------------------------------- PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK TYS--------------------------------------------------------- YAK_a_Smoe_YAK TYS--------------------------------------------------------- YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 GLTSKL------------------------------------------------------ GK034_Glam_DYRK2 YWGQQ------------------------------------------------------- GK033_Glam_DYRK2 FMRKSRAYSQAFQALVPSAAPVTLLQSALNASKRIGPLEEDTSDTTTLNSLAAIPTAASS GK032_Glam_DYRK2 ADV--------------------------------------------------------- PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 LQTTMGQQLSSTLQESQGIFGLSSTNPLQVPSQVQPKMGVLASKIRNQHSLSAEESRMQA GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 STKENKDSMKFRVVQNATPSTTKVESVNYRDLIMEHLSSPQATIEAKLQSALTADERQKF GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 DSTVRSFAEKLRAKELSYSSILSNLFDGLSAPSGSQVQGSGRPGSNYGQSTSSLPTGIEQ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 FSSRGDSDTRTDPSDHDFDSDMALSGNEEYEDINLGDEDQAQFAASAGQVSIGNSVSMDS GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 MIRTTNEFIKATSASGLSEQIESSAQSLQSTGSLHRSDVHSSSVGALGHVGAHHIRPQSS GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 -----------------------------------------------YLAE--------- HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ----------------------SEE----------------------------------- HIPK2_Hsap_HIPK ----------------------SEE----------------------------------- HIPK1_Hsap_HIPK ----------------------SEE----------------------------------- smi35A_Dmel_DYRK2 ----------------------KNY----------------------------------- mnb_Dmel_DYRK1 ----------------------AQQ----------------------------------- Dyrk3_Dmel_DYRK2 ----------------------KRP----------------------------------- CG17090_Dmel_HIPK ----------------------RQT----------------------------------- PRP4_Mmus_PRP4 -----------------------------------------------YLAE--------- HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ----------------------SEE----------------------------------- HIPK2_Mmus_HIPK ----------------------SEE----------------------------------- HIPK1_Mmus_HIPK ----------------------SEE----------------------------------- DYRK4_Mmus_DYRK2 ----------------------KLN----------------------------------- DYRK3_Mmus_DYRK2 ----------------------KRQ----------------------------------- DYRK2_Mmus_DYRK2 ----------------------KRQ----------------------------------- DYRK1B_Mmus_DYRK1 ----------------------AQQ----------------------------------- DYRK1A_Mmus_DYRK1 ----------------------HQQ----------------------------------- mbk-2_Cele_DYRK2 ----------------------KQA----------------------------------- mbk-1_Cele_DYRK1 ----------------------RDRH---------------------------------- hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 -----------------------------------------------GHTE--------- C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ----------------------KLD----------------------------------- DYRK3_Hsap_DYRK2 ----------------------KRH----------------------------------- DYRK2_Hsap_DYRK2 ----------------------KRQ----------------------------------- DYRK1B_Hsap_DYRK1 ----------------------AQQ----------------------------------- DYRK1A_Hsap_DYRK1 ----------------------HQQ----------------------------------- YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ----------------------KQQAQQQAQQQAQQLQQQAQQQQHQLQQQQQLLQQQQQ Dyrk2_Ddis_DYRK2 ----------------------KTK----------------------------------- Prp4_Ddis_PRP4 -----------------------------------------------KEQP--------- YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ----------------------LYQ-------------------------IASVVSQHQK 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ----------------------K------------------------------------- 5356_Tthe_DYRK2 ----------------------KPA----------------------------------- 5655_Tthe_DYRK2 ----------------------KKF----------------------------------- 15575_Tthe_PRP4 -----------------------------------------------VQGM--------- DYRK1_Spur_DYRK1 ----------------------ALP----------------------------------- DYRK2_Spur_DYRK2 ----------------------KRQ----------------------------------- DYRK4_Spur_DYRK2 ----------------------KVE----------------------------------- HIPKa_Spur_HIPK ----------------------SEE----------------------------------- HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 -----------------------------------------------VAPA--------- CG7028_Dmel_PRP4 -----------------------------------------------TGQE--------- CC1G_13957_Ccin_DYRK2 ----------------------KKM----------------------------------- CC1G_04865_Ccin_PRP4 -----------------------------------------------HV----------- CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ----------------------DRT----------------------------------- AqueK112_Aque_DYRK2 ----------------------KIE----------------------------------- AqueK113_Aque_DYRK2 ----------------------KRQ----------------------------------- AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ----------------------KIQ----------------------------------- DYRK2_a_Smoe_DYRK2 ----------------------KIQ----------------------------------- DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 -----------------------------------------------LEEG--------- PRP4_d_Smoe_PRP4 -----------------------------------------------LEEG--------- PRP4_b_Smoe_PRP4 -----------------------------------------------MQQN--------- PRP4_a_Smoe_PRP4 -----------------------------------------------MQQS--------- PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 KAVSSISSAMNMATSLYSQTQLSTG----------------------------------- GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 QQQQQQQQQQQQQQQQQQQQQQQQQYQQQHNNNINNNNNNSNINNKNNNNNNTNFNTSNN Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ILFDMQ------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------QIIEQQSVSLG------------------------- PRP4_d_Smoe_PRP4 ------------------------QIVEQESVSLG------------------------- PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 NNNTNNNSNNNSNNNNSNNNNNNNNINNINNININNKNNNNNNNNNNNINNINNNNNKNN Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 -----------------------------------------------------D------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 -----------------------------------------------------D------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 -----------------------------------------------------ENT---- C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 NNNNNNNNNDDNNNINNNNSNNNNNNNNNNNNNNNNNNNNNNNNNSNNNNNNNNLNNNNS Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ---------------------------------QPITSSLST------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK -----------------------------------------------------------K 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 -------------------------------QMQKQEASQTFSKEN-------------- DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 -----------------------------------------------------E------ CG7028_Dmel_PRP4 -----------------------------------------------------SPAPH-- CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 -------------------------------N---------------------------- PRP4_d_Smoe_PRP4 -------------------------------N---------------------------- PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ---------------------------------QPEEPAETMKVSKPLTAAEPD------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ----------------------SNM----------SVP-----------SE-P-SSP--- HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ----------------------SNI----------SVP-----------SE-P-SSP--- HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 --------KSQDAGKPKGSKDGSGASLTDTFSIHNAIPITSSDNHYQQDAH-Q-NAP--- hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 -------------------------------------P-----------RD-S-STP--- C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK --------T--------------------------------------------------- Dyrk1_Ddis_DYRK1 NNNYNNNTT--------------------------------------------------- Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 -------------------------------------------------TE-KEQSN--- YakA_Ddis_YAK --------S--------------------------------------------------- 22349_Tthe_YAK AQNTRH------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 -----------------------------------------------------N------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ----------------------SAT----------SSP-----------AQGP-SEP--- CG7028_Dmel_PRP4 ----------------------NSV----------SYE-----------SR-S-TSQ--- CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 --------------------------------------------------------N--- CC1G_14245_Ccin_YAK --------S--------------------------------------------------- AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 --------------------------------------------------------T--- DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 --------------------------------------------------------PVPH PRP4_d_Smoe_PRP4 --------------------------------------------------------PVPH PRP4_b_Smoe_PRP4 ----------------------SGE----------GI------------ID-P-STP--- PRP4_a_Smoe_PRP4 ----------------------SGE----------GI------------ID-P-STP--- PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK --------D--------------------------------------------------- YAK_a_Smoe_YAK --------D--------------------------------------------------- YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 -----QS--S-------------------------------------------------- HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------LDN--------- HIPK2_Hsap_HIPK ------------------------------------------------IEN--------- HIPK1_Hsap_HIPK ------------------------------------------------VDS--------- smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------DCDCGCVDSYNS PRP4_Mmus_PRP4 -----QS--S-------------------------------------------------- HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------LEN--------- HIPK2_Mmus_HIPK ------------------------------------------------IEN--------- HIPK1_Mmus_HIPK ------------------------------------------------VES--------- DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 -----PL--L-------------------------------------------------- hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 -----RS--DTIGDKKTDESEDSSSDSEDDED---------------------------- C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 -----TN--T-------------------------------------------------- YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ---------------QNN--------QTQNKNDQDVVDDKLKVKDSENLEN--------- DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------LDN--------- HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 -----SS--T-------------------------------------------------- CG7028_Dmel_PRP4 -----GS--S-------------------------------------------------- CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 -----GQ--S-------------------------------------------------- CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 -----GL----------------------------------------------------- DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 DTAKIASNSC-------------------------------------------------- PRP4_d_Smoe_PRP4 DTAKIASNSC-------------------------------------------------- PRP4_b_Smoe_PRP4 -----LS--L-------------------------------------------------- PRP4_a_Smoe_PRP4 -----LS--L-------------------------------------------------- PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK --------HSSA----------------MQIVDEL---------SIL------------- HIPK2_Hsap_HIPK --------TSS-----------------VQIIEEH------------------------- HIPK1_Hsap_HIPK --------NGS-----------------VQIIEEH------------------------- smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK SHGPPVQQDSSAAAGAGSVGSKAGSGPGP--DG------------IG------------- PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK --------HSGA----------------MQIVDEL---------SIL------------- HIPK2_Mmus_HIPK --------TSS-----------------VQIIEEH------------------------- HIPK1_Mmus_HIPK --------NGS-----------------VQIIEEH------------------------- DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ----------------------------V--IP------------AA------------- F22D6.5_Cele_PRP4 ----------------------------------------------------DRKLAEAK C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 --------QNF--------------------ADENSEEQLFDDTGLNPNDVLD------D DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK --------HSTA----------------ARG----------------------------- HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 --------------------------------------------------------TRTR HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK -----------------------------------------------------P------ HIPK2_Hsap_HIPK -----------------------------------------------------P------ HIPK1_Hsap_HIPK -----------------------------------------------------P------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK -----------------------------------------------------P------ PRP4_Mmus_PRP4 --------------------------------------------------------TRSR HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK -----------------------------------------------------P------ HIPK2_Mmus_HIPK -----------------------------------------------------P------ HIPK1_Mmus_HIPK -----------------------------------------------------P------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 --------------------------------------------------------DTN- hpk-1_Cele_HIPK -----------------------------------------------------P------ F22D6.5_Cele_PRP4 DLIKSTRFG-----------------------------------SEQGSGASTPVSIQSD C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 --------------------------------------------------------NSN- YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 DDVNIANTINDDYKEEVDESHSLTHRHSIDKAQLDHLKFLEDMRNQE-IKGGIPD----- DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 --------------------------------------------------------P--- CG7028_Dmel_PRP4 --------------------------------------------------------QRER CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 -------------------------------------------------G-------SA- CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 --------------------------------------------------------GKS- PRP4_a_Smoe_PRP4 --------------------------------------------------------GKS- PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 S-PSPD-----DILERVA---------------------------------AD------V HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ---------------------------------AML--QT-------------------- HIPK2_Hsap_HIPK ---------------------------------PMI--QN-------------------- HIPK1_Hsap_HIPK ---------------------------------PLM--LQ-------------------- smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ---------------------------------ISSLKTA-------------------- PRP4_Mmus_PRP4 S-PSPD-----DILERVA---------------------------------AD------V HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ---------------------------------AML--QT-------------------- HIPK2_Mmus_HIPK ---------------------------------PMI--QN-------------------- HIPK1_Mmus_HIPK ---------------------------------PLM--LQ-------------------- DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 --APPT-----S------------------------------------------------ hpk-1_Cele_HIPK ---------------------------------AIS--SA-------------------- F22D6.5_Cele_PRP4 N-DTPT-----DFFSGLRDKMVHMKDADEHNVDEVL--QRGKDEEYREDWHTQ------L C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 --STPVATTTTSILAKSP---------------------------------SN------L YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ---MPE-----QPI---------------------------------------------- DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ----------------------------------MT--DT-------------------- HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 --QSPQ-----ASEQGGS---------------------------------TA------Q CG7028_Dmel_PRP4 PLRTPS-----PTMPCPN---------------------------------PL------I CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ---IDV-----D----------------------------------------MEDEDEDD CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------V----------------------- AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 --ALP----NGTILKRNA---------------------------------GG------L PRP4_a_Smoe_PRP4 --ALP----NGTILKRNA---------------------------------GG------L PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 -KE--YE---------------------------------RENV---------------- HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 -KE--YE---------------------------------RENV---------------- HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 -KE--QE---------------------------------KREE---------------- C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ENQ--IEEEDESIIIEWRKDQNSENSSAFNDNNNDESCSSEEDL---------------- YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 -SQDTDD---------------------------------EDDDEEEEEEDEEEDDSEKS CG7028_Dmel_PRP4 -SEIPKD---------------------------------REDM---------------- CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 -EA--DE---------------------------------ESEE---------------- CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 G----------------------------------------------------------- PRP4_a_Smoe_PRP4 G----------------------------------------------------------- PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 -----DTF----E-----------------------------A--------SVKAK-HN- HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 -----DTF----E-----------------------------A--------SVKAK-HN- HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 -----E---------------------------------------------EKKKK-LE- C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 -----KKRGKIKE-----------------------------E--------DIKAKDKP- YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ----------------------------------------------------LKQKR-K- DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 SSSDSDDD----SSEVESKASSDDDDDDEEDDEGDAARIEEEERLREEEEEAEQEK-RRE CG7028_Dmel_PRP4 -----DNS---------------------------------------------------- CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 -----EDL----D-----------------------------D--------M-----FA- CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ----------------------------------LMTVEQNNG----------------- HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ----------------------------------LMTVEQNNG----------------- HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ----------------------------------AEAAAEAAK----------------- C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ----------------------------------ITTTTTTTT---INNVSIKLPPKPE- YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ----------------------------------SINSEKLEGKFSNND-----QLDEE- DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 MERKRLKEAFPQSDSEDEESAANSKKGEGSLDKNLSDIVKPKS----------------- CG7028_Dmel_PRP4 -------------------------------------TSQKTC----------------- CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ----------------------------------VALGGDEEK----------------- CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ---------------------------------------------------EGSPPKVRI PRP4_a_Smoe_PRP4 ---------------------------------------------------EGSPP---- PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ---------S--SQK--KLLAPDMFTESDDMF--AAYFDS-AR-L--RAAG------IGK HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ---N------------------------------------MGNP--------------VT HIPK2_Hsap_HIPK ---N-----------------------------------ASGATV-------------AT HIPK1_Hsap_HIPK ---N-----------------------------------RTV-VG-------------AA smi35A_Dmel_DYRK2 ---------------------------------------N-------------------K mnb_Dmel_DYRK1 ---------------------------------------TQGD-D------------DSS Dyrk3_Dmel_DYRK2 ---------------------------------------G-------------------- CG17090_Dmel_HIPK ---H-----------------------------------TKVATS-------------GG PRP4_Mmus_PRP4 ---------S--SQK--KILAPDMFTESDDMF--AAYFDS-AR-L--RAAG------IGK HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ---N------------------------------------MGNP--------------VT HIPK2_Mmus_HIPK ---N-----------------------------------ASGATV-------------AT HIPK1_Mmus_HIPK ---N-----------------------------------RTV-VG-------------AA DYRK4_Mmus_DYRK2 ---------------------------------------V-------------------- DYRK3_Mmus_DYRK2 ---------------------------------------G-------------------- DYRK2_Mmus_DYRK2 ---------------------------------------G-------------------- DYRK1B_Mmus_DYRK1 ---------------------------------------APPQ--------------DSS DYRK1A_Mmus_DYRK1 ---------------------------------------GQGD--------------DSS mbk-2_Cele_DYRK2 ---------------------------------------G-------------------- mbk-1_Cele_DYRK1 ------------------TMVVPMRTET--------DLQQ-QQ-R--------------Q hpk-1_Cele_HIPK ---N-----------------------------------NKMAPQ-------------SV F22D6.5_Cele_PRP4 ---------K--KKQEEDDTGFDMFADNEE---------L-PQ-D--STTI------DGH C36B7.2_Cele_DYRK2 --------------------------------------------P------------E-T C36B7.1_Cele_DYRK2 --------------------------------------------G------------S-K DYRK4_Hsap_DYRK2 ---------------------------------------T-------------------- DYRK3_Hsap_DYRK2 ---------------------------------------G-------------------- DYRK2_Hsap_DYRK2 ---------------------------------------G-------------------- DYRK1B_Hsap_DYRK1 ---------------------------------------APPQ--------------DSS DYRK1A_Hsap_DYRK1 ---------------------------------------GQGD--------------DSS YAK1_Scer_YAK ------------------------------------S-KN-PK-R-------------VL Dyrk1_Ddis_DYRK1 ------------------------------------TTSS-SN-N-------------N- Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ----------PIKAKT-SAPVFDMFSDSPS----DETDES-NR-DLNETNGGGVMVDANI YakA_Ddis_YAK ------------------------------------S-LN-PR-R-------------VL 22349_Tthe_YAK -------------------------------------FNQ-IN-Q-------------E- 10580_Tthe_DyrkP -----------------------------------------------------------D 22423_Tthe_DyrkP -----------------------------------------------------------N 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ---------------------------------------R-------------------S 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ----NK--LHKLDDQEDSEEETDMFGDDID----K--IINKSN-D-------------GK DYRK1_Spur_DYRK1 ---------------------------------------AQGD--------------DTS DYRK2_Spur_DYRK2 ---------------------------------------G-------------------- DYRK4_Spur_DYRK2 ---------------------------------------G-------------------- HIPKa_Spur_HIPK ---S------------------------------------VKNE--------------LT HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ---------D--KEQAMANNGLDMFSEVD-M-----FKMS-PS-T--R-EG------IGQ CG7028_Dmel_PRP4 ---------S--AKE--KRNEWDMFADQD-VD---SNFDS-PN-T--I--V------QNK CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ---------P--KKK--K-----------------KKATGKKK-T--KE-N------AAQ CC1G_14245_Ccin_YAK ------------------------------------A-HN-PR-R-------------VL AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ---------------------------------------DQSN-G------------AGA AqueK112_Aque_DYRK2 ---------------------------------------G-------------------- AqueK113_Aque_DYRK2 ---------------------------------------G-------------------- AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ---------S--AMK--TAVVLDIFSEED-ITGKEKSWLS-PS-K--A--L------LAD DYRK2_b_Smoe_DYRK2 ---------------------------------------V-------------------V DYRK2_a_Smoe_DYRK2 ---------------------------------------V-------------------V DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP -----------------------------------------------------------D PRP4_e_Smoe_PRP4 ---------D--KSS--SPPAQDMFSETPL-----AEITN-PE-A--------------S PRP4_d_Smoe_PRP4 ---------D--KSS--SPPAQDMFTETPL-----AEIIN-PE-A--------------S PRP4_b_Smoe_PRP4 CLRKNLLISSSLQSEKPADMFCDIFGESPA----EIRKAG-TR-D--------------T PRP4_a_Smoe_PRP4 ------------KSEKPADMFCDIFGESPA----EIRKAG-TR-D--------------T PRP4_c_Smoe_PRP4 -------------------------------------ITN-PE-A--------------S YAK_b_Smoe_YAK ------------------------------------T-FN-PK-R-------------YL YAK_a_Smoe_YAK ------------------------------------T-FN-PK-R-------------YL YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 --------------------------------------------R------------T-G GK034_Glam_DYRK2 -----------------------------------------------------------A GK033_Glam_DYRK2 ---------------------------------------APTQ--------------TAS GK032_Glam_DYRK2 -----------------------------------------------------------L PRP4_Hsap_PRP4 DF---------------------------------------------------------- HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK VV---------------------------------------------------------- HIPK2_Hsap_HIPK AT---------------------------------------------------------- HIPK1_Hsap_HIPK AT---------------------------------------------------------- smi35A_Dmel_DYRK2 PA---------------------------------------------------------- mnb_Dmel_DYRK1 NK---------------------------------------------------------- Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK HA---------------------------------------------------------- PRP4_Mmus_PRP4 DF---------------------------------------------------------- HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK VV---------------------------------------------------------- HIPK2_Mmus_HIPK AT---------------------------------------------------------- HIPK1_Mmus_HIPK AT---------------------------------------------------------- DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 TK---------------------------------------------------------- DYRK1A_Mmus_DYRK1 HK---------------------------------------------------------- mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 KS---------------------------------------------------------- hpk-1_Cele_HIPK TA---------------------------------------------------------- F22D6.5_Cele_PRP4 SG---------------------------------------------------------- C36B7.2_Cele_DYRK2 LK---------------------------------------------------------- C36B7.1_Cele_DYRK2 NQ---------------------------------------------------------- DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 NK---------------------------------------------------------- DYRK1A_Hsap_DYRK1 HK---------------------------------------------------------- YAK1_Scer_YAK TK---------------------------------------------------------- Dyrk1_Ddis_DYRK1 NN---------------------------------------------------------- Dyrk2_Ddis_DYRK2 F----------------------------------------------------------- Prp4_Ddis_PRP4 VV---------------------------------------------------------- YakA_Ddis_YAK TH---------------------------------------------------------- 22349_Tthe_YAK KS---------------------------------------------------------- 10580_Tthe_DyrkP LK---------------------------------------------------------- 22423_Tthe_DyrkP LK---------------------------------------------------------- 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 EI---------------------------------------------------------- 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 L----------------------------------------------------------- DYRK1_Spur_DYRK1 HK---------------------------------------------------------- DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK GM---------------------------------------------------------- HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 MG---------------------------------------------------------- CG7028_Dmel_PRP4 HQ---------------------------------------------------------- CC1G_13957_Ccin_DYRK2 AT---------------------------------------------------------- CC1G_04865_Ccin_PRP4 TL---------------------------------------------------------- CC1G_14245_Ccin_YAK TK---------------------------------------------------------- AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 SS---------------------------------------------------------- AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK -D---------------------------------------------------------- AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 GI---------------------------------------------------------- DYRK2_b_Smoe_DYRK2 G----------------------------------------------------------- DYRK2_a_Smoe_DYRK2 G----------------------------------------------------------- DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP LK---------------------------------------------------------- PRP4_e_Smoe_PRP4 VQ---------------------------------------------------------- PRP4_d_Smoe_PRP4 GQ---------------------------------------------------------- PRP4_b_Smoe_PRP4 LA---------------------------------------------------------- PRP4_a_Smoe_PRP4 LA---------------------------------------------------------- PRP4_c_Smoe_PRP4 VQ---------------------------------------------------------- YAK_b_Smoe_YAK TN---------------------------------------------------------- YAK_a_Smoe_YAK TN---------------------------------------------------------- YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 VN---------------------------------------------------------- GK034_Glam_DYRK2 NK---------------------------------------------------------- GK033_Glam_DYRK2 KNGSSDAPAVVYTPVPPMADDITKSCLRLEISVTSMDVAEAGGTAMSGKDEKVFQSSVPL GK032_Glam_DYRK2 QQ---------------------------------------------------------- PRP4_Hsap_PRP4 ----------------------K------------------------------------- HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ----------------------T------------------------------------- HIPK2_Hsap_HIPK ----------------------T------------------------------------- HIPK1_Hsap_HIPK ----------------------T------------------------------------- smi35A_Dmel_DYRK2 ----------------------P------------------------------------- mnb_Dmel_DYRK1 ----------------------K------------------------------------- Dyrk3_Dmel_DYRK2 ----------------------V------------------------------------- CG17090_Dmel_HIPK ----------------------N------------------------------------- PRP4_Mmus_PRP4 ----------------------K------------------------------------- HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ----------------------T------------------------------------- HIPK2_Mmus_HIPK ----------------------T------------------------------------- HIPK1_Mmus_HIPK ----------------------T------------------------------------- DYRK4_Mmus_DYRK2 ----------------------V------------------------------------- DYRK3_Mmus_DYRK2 ----------------------V------------------------------------- DYRK2_Mmus_DYRK2 ----------------------M------------------------------------- DYRK1B_Mmus_DYRK1 ----------------------K------------------------------------- DYRK1A_Mmus_DYRK1 ----------------------K------------------------------------- mbk-2_Cele_DYRK2 ----------------------V------------------------------------- mbk-1_Cele_DYRK1 ----------------------S------------------------------------- hpk-1_Cele_HIPK ----------------------T------------------------------------- F22D6.5_Cele_PRP4 ----------------------A------------------------------------- C36B7.2_Cele_DYRK2 ----------------------A------------------------------------- C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ----------------------A------------------------------------- DYRK3_Hsap_DYRK2 ----------------------V------------------------------------- DYRK2_Hsap_DYRK2 ----------------------M------------------------------------- DYRK1B_Hsap_DYRK1 ----------------------K------------------------------------- DYRK1A_Hsap_DYRK1 ----------------------K------------------------------------- YAK1_Scer_YAK ----------------------P------------------------------------- Dyrk1_Ddis_DYRK1 ----------------------N------------------------------------- Dyrk2_Ddis_DYRK2 ----------------------N------------------------------------- Prp4_Ddis_PRP4 ----------------------N------------------------------------- YakA_Ddis_YAK ----------------------P------------------------------------- 22349_Tthe_YAK ----------------------L------------------------------------- 10580_Tthe_DyrkP ----------------------I------------------------------------- 22423_Tthe_DyrkP ----------------------V------------------------------------- 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ----------------------Q------------------------------------- 5655_Tthe_DYRK2 ----------------------Q------------------------------------- 15575_Tthe_PRP4 ----------------------Q------------------------------------- DYRK1_Spur_DYRK1 ----------------------K------------------------------------- DYRK2_Spur_DYRK2 ----------------------V------------------------------------- DYRK4_Spur_DYRK2 ----------------------V------------------------------------- HIPKa_Spur_HIPK ----------------------I------------------------------------- HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ----------------------P------------------------------------- CG7028_Dmel_PRP4 ----------------------H------------------------------------- CC1G_13957_Ccin_DYRK2 ----------------------P------------------------------------- CC1G_04865_Ccin_PRP4 ----------------------G------------------------------------- CC1G_14245_Ccin_YAK ----------------------P------------------------------------- AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ----------------------S------------------------------------- AqueK112_Aque_DYRK2 ----------------------V------------------------------------- AqueK113_Aque_DYRK2 ----------------------V------------------------------------- AqueK114_Aque_HIPK ----------------------K------------------------------------- AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ----------------------G------------------------------------- DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ----------------------I------------------------------------- PRP4_e_Smoe_PRP4 ----------------------G------------------------------------- PRP4_d_Smoe_PRP4 ----------------------G------------------------------------- PRP4_b_Smoe_PRP4 ----------------------I------------------------------------- PRP4_a_Smoe_PRP4 ----------------------I------------------------------------- PRP4_c_Smoe_PRP4 ----------------------G------------------------------------- YAK_b_Smoe_YAK ----------------------P------------------------------------- YAK_a_Smoe_YAK ----------------------P------------------------------------- YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ----------------------Q------------------------------------- GK034_Glam_DYRK2 ----------------------Q------------------------------------- GK033_Glam_DYRK2 LPVTAYCDINAVIDTAVSGLDASDAKNSAKDKYKTILQVIRGQLDQTSLMNTTACSKLPI GK032_Glam_DYRK2 ----------------------I------------------------------------- PRP4_Hsap_PRP4 ------ENPNLRDNW--TDA----------E-G------------------YYRVNIGEV HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------ATTGSKQNC--TTG----------E-G------------------DYQLVQHEV HIPK2_Hsap_HIPK ------STATSKNSG--SNS----------E-G------------------DYQLVQHEV HIPK1_Hsap_HIPK ------TTVTTKSSS--SSG----------E-G------------------DYQLVQHEI smi35A_Dmel_DYRK2 ------TANTTNLGY--DDD----------N-G------------------NYKIIEHDH mnb_Dmel_DYRK1 ------ERKLYNDGY--DDD----------N-H------------------DYIIKNGEK Dyrk3_Dmel_DYRK2 ------Y-GPNNSEY--DNE----------Q-G------------------AYIHVPHDH CG17090_Dmel_HIPK ------TQPPSKRSS--SGA----------D-G------------------DYQLVQHEV PRP4_Mmus_PRP4 ------ENPNLRDNW--TDA----------E-G------------------YYRVNIGEV HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------ATTGSKQNC--TSG----------E-G------------------DYQLVQHEV HIPK2_Mmus_HIPK ------STATSKNSG--SNS----------E-G------------------DYQLVQHEV HIPK1_Mmus_HIPK ------TTVTTKSSS--SSG----------E-G------------------DYQLVQHEI DYRK4_Mmus_DYRK2 ------PEKFSKTSF--DDE----------H-G------------------SYMKVLHDH DYRK3_Mmus_DYRK2 ------IGGPNNGGY--DDA----------D-G------------------AYIHVPRDH DYRK2_Mmus_DYRK2 ------TGGPNNGGY--DDD----------Q-G------------------SYVQVPHDH DYRK1B_Mmus_DYRK1 ------EKKVLNHGY--DDD----------N-H------------------DYIVRSGER DYRK1A_Mmus_DYRK1 ------ERKVYNDGY--DDD----------N-Y------------------DYIVKNGEK mbk-2_Cele_DYRK2 ------IGGANNGGY--DDE----------N-G------------------SYQLVVHDH mbk-1_Cele_DYRK1 ------RGGPYNNGY--DDQ----------N-Y------------------DYILKNGEI hpk-1_Cele_HIPK ------AKTTTNRGK--VSG----------E-G------------------EYQLIKNEV F22D6.5_Cele_PRP4 ------VHDTLKDNW--DDV----------E-G------------------YYRVRIGEL C36B7.2_Cele_DYRK2 ------PENAIEKDF--FEM----------G-S------------------IYKMKKDEH C36B7.1_Cele_DYRK2 -------TNHELGIF--TLP----------N-G------------------SYCFKEGDH DYRK4_Hsap_DYRK2 ------PEKFSKTSF--DDE----------H-G------------------FYLKVLHDH DYRK3_Hsap_DYRK2 ------IGGPNNGGY--DDA----------D-G------------------AYIHVPRDH DYRK2_Hsap_DYRK2 ------TGGPNNGGY--DDD----------Q-G------------------SYVQVPHDH DYRK1B_Hsap_DYRK1 ------EKKVLNHGY--DDD----------N-H------------------DYIVRSGER DYRK1A_Hsap_DYRK1 ------ERKVYNDGY--DDD----------N-Y------------------DYIVKNGEK YAK1_Scer_YAK ------SEGKCNNGF--DNI----------N-S------------------DYILYVNDV Dyrk1_Ddis_DYRK1 ------KQSKYNDGY--DDE----------N-A------------------DYIVRIGEV Dyrk2_Ddis_DYRK2 ------S-QLPNNGY--DND----------I-G------------------EYKVVERDH Prp4_Ddis_PRP4 ------PSINLSDNW--DDA----------D-G------------------YYKFRVGE- YakA_Ddis_YAK ------SEPLSNDGY--DNV----------N-S------------------DYIVYVNDI 22349_Tthe_YAK ------IL-QSNRWFINDQQ----------DLN------------------YYIQYI--N 10580_Tthe_DyrkP ------ITDRERTGF---EE----------T-K------------------EFPIVINSI 22423_Tthe_DyrkP ------IFDRERTGF---EE----------T-K------------------EFPIVINSI 5306_Tthe_DYRK2 -------AAQENGNN--DDT----------K-G------------------DYQYNVNDH 5356_Tthe_DYRK2 ------QANSYNFGY--DDENLQKYYLIIKR-G------------------DYLYTLNDH 5655_Tthe_DYRK2 ------KTSQFNNGF--DDS----------R-G------------------EYQLNLLDH 15575_Tthe_PRP4 ------IVKGANAEC--DDE----------Q-N------------------YFKILIGEV DYRK1_Spur_DYRK1 ------EKRLYNDGY--DDD----------N-Y------------------DYIIKNGEK DYRK2_Spur_DYRK2 ------IGGASNCGY--DDD----------Q-G------------------SYIHVQHDH DYRK4_Spur_DYRK2 ------QGASQNNGY--DDE----------N-G------------------SYIKVIHDH HIPKa_Spur_HIPK ------TRTGSKKSS--SGG----------E-G------------------DYQLVQHEV HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------ENPSLTDNW--DDE----------E-G------------------YYRVRIGES CG7028_Dmel_PRP4 ------ENPALTDNW--DDA----------E-G------------------YYRVRIGEV CC1G_13957_Ccin_DYRK2 ------DITTNNYSY--DDE----------R-G------------------DYQVVLGDH CC1G_04865_Ccin_PRP4 ------APNVIVDAA--ADP----------E-G------------------YYRVILGER CC1G_14245_Ccin_YAK ------SKPVHNEGY--DNE----------D-Y------------------DYILYVNDW AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------RRSIKSEQY--DDE----------N-H------------------DYKVKPGER AqueK112_Aque_DYRK2 ------PGGSQNCGY--DDE----------N-G------------------SYIKVLHDH AqueK113_Aque_DYRK2 ------IGAPQNSGY--DDD----------A-G------------------TYLIVAHDH AqueK114_Aque_HIPK ------GEVDQTKLG--GGP----------S-G------------------DYPVSIREL AqueK115_Aque_PRP4 ------------------------------------------------------VRIGEQ AqueK116_Aque_PRP4 ------ENDHLTDNW--DDA----------E-G------------------YYRVRIGEQ DYRK2_b_Smoe_DYRK2 ------GQGRYNYGF--DTE----------K-G------------------DYNAIMQDH DYRK2_a_Smoe_DYRK2 ------GQGRYNYGF--DTE----------K-G------------------DYNAIMQDH DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------IHRKNRTGF---EE----------D-K------------------DFQVLINSV PRP4_e_Smoe_PRP4 ------LRNDNPDNW--HDH----------E-F------------------YYKARIGET PRP4_d_Smoe_PRP4 ------VRNDNPDNW--HDQ----------E-F------------------YYKARVGET PRP4_b_Smoe_PRP4 ------DTSGLTDNW--DDA----------D-G------------------YYTYRVGEV PRP4_a_Smoe_PRP4 ------DTSGLTDNW--DDA----------D-G------------------YYTYRVGEV PRP4_c_Smoe_PRP4 ------LRNDNPDNW--HDH----------E-F------------------YYKARIGET YAK_b_Smoe_YAK ------SAGVSNNGL--DNK----------N-S------------------DLILAVNGI YAK_a_Smoe_YAK ------SAGVSNNGL--DNK----------N-S------------------DLILAVNGI YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------PQMASMRPQ--TDD----------R-G------------------YLIVRINDC GK034_Glam_DYRK2 ------YNGAINHGY--DDS----------R-G------------------DYIGVINDH GK033_Glam_DYRK2 YYNPLHTGAIEVTT----PD----------D-A------------------DVPFIEGET GK032_Glam_DYRK2 -----YKGETRNSKL--LDL----------V-GFYNIPLYYGLYSEFKGLHEMRFKKGAV PRP4_Hsap_PRP4 LD-----KRYNVYG--YT-GQGVFSNVVRARDNAR--------------ANQEVAVKIIR HIPK4_Hsap_HIPK ----SETDCYDIIE--VL-GKGTFGEVAKGWRRS---------------TGEMVAIKILK HIPK3_Hsap_HIPK LC--SMKNTYEVLD--FL-GRGTFGQVVKCWKRG---------------TNEIVAIKILK HIPK2_Hsap_HIPK LC--SMTNTYEVLE--FL-GRGTFGQVVKCWKRG---------------TNEIVAIKILK HIPK1_Hsap_HIPK LC--SMTNSYEVLE--FL-GRGTFGQVAKCWKRS---------------TKEIVAIKILK smi35A_Dmel_DYRK2 -----IAFRYEILE--VI-GKGSFGQVIRALDHK---------------TNTHVAIKIIR mnb_Dmel_DYRK1 -----FLDRYEIDS--LI-GKGSFGQVVKAYDHE---------------EQCHVAIKIIK Dyrk3_Dmel_DYRK2 -----VAYRYEMLK--II-GKGSFGQVIKAYDHK---------------THEHVALKIVR CG17090_Dmel_HIPK LY--SLSAEYEVLE--FL-GRGTFGQVVKCWKRG---------------TSEIVAIKILK PRP4_Mmus_PRP4 LD-----KRYNVYG--YT-GQGVFSNVVRARDNAR--------------ANQEVAVKIIR HIPK4_Mmus_HIPK ----SETDCYDIIE--VL-GKGTFGEVAKGWRRS---------------TGEMVAIKILK HIPK3_Mmus_HIPK LC--SMKNTYEVLD--FL-GRGTFGQVVKCWKRG---------------TNEIVAIKILK HIPK2_Mmus_HIPK LC--SMTNTYEVLE--FL-GRGTFGQVVKCWKRG---------------TNEIVAIKILK HIPK1_Mmus_HIPK LC--SMTNSYEVLE--FL-GRGTFGQVAKCWKRS---------------TKEIVAIKILK DYRK4_Mmus_DYRK2 -----IAYRYEVLE--MI-GKGSFGQVAKCLDHK---------------NNELVALKIIR DYRK3_Mmus_DYRK2 -----LAYRYEVLK--II-GKGSFGQVARVYDHK---------------LRQYVALKMVR DYRK2_Mmus_DYRK2 -----VAYRYEVLK--VI-GKGSFGQVVKAYDHK---------------VHQHVALKMVR DYRK1B_Mmus_DYRK1 -----WLERYEIDS--LI-GKGSFGQVVKAYDHQ---------------TQELVAIKIIK DYRK1A_Mmus_DYRK1 -----WMDRYEIDS--LI-GKGSFGQVVKAYDRV---------------EQEWVAIKIIK mbk-2_Cele_DYRK2 -----IAYRYEVLK--VI-GKGSFGQVIKAFDHK---------------YQQYVALKLVR mbk-1_Cele_DYRK1 F-----DKRYVILSDTPV-GKGSFGQVTKAYDTL---------------NKEEVAIKIIK hpk-1_Cele_HIPK LC-SPYGNQYEVLE--FL-GKGTFGQVVKAWKKG---------------TSEIVAIKILK F22D6.5_Cele_PRP4 LD-----TRYRVVG--FT-GAGVFGNVCRCNDQT---------------KGNTVAVKIIR C36B7.2_Cele_DYRK2 -----IGYRYTIDK--VI-GQGCYGVVGEATDGK---------------TKQKVAIRMVS C36B7.1_Cele_DYRK2 -----ISYRYSIDE--VL-SSGYYAQVFRCTDKK---------------TDKKVCIKLKN DYRK4_Hsap_DYRK2 -----IAYRYEVLE--TI-GKGSFGQVAKCLDHK---------------NNELVALKIIR DYRK3_Hsap_DYRK2 -----LAYRYEVLK--II-GKGSFGQVARVYDHK---------------LRQYVALKMVR DYRK2_Hsap_DYRK2 -----VAYRYEVLK--VI-GKGSFGQVVKAYDHK---------------VHQHVALKMVR DYRK1B_Hsap_DYRK1 -----WLERYEIDS--LI-GKGSFGQVVKAYDHQ---------------TQELVAIKIIK DYRK1A_Hsap_DYRK1 -----WMDRYEIDS--LI-GKGSFGQVVKAYDRV---------------EQEWVAIKIIK YAK1_Scer_YAK LG-VEQNRKYLVLD--IL-GQGTFGQVVKCQNLL---------------TKEILAVKVVK Dyrk1_Ddis_DYRK1 F-----VDRFEIIS--SL-GKGSFGQVVKAFDSV---------------LKEYVAIKIIK Dyrk2_Ddis_DYRK2 -----IAYRFEIVS--IL-GQGSFCQVVKGYDYK---------------TGEMVALKILR Prp4_Ddis_PRP4 IM-----DKYQIFS--PI-GSGVFSTVVSAKETKT---------------NEDVVIKIIR YakA_Ddis_YAK ITNNESGQKYKVLD--SL-GQGTFGQVVKCKNCD---------------TDELVAIKILK 22349_Tthe_YAK W-----LIEYIIED--ML-GKGTFGQVAKCSKNG---------------TNDLFAVKVIK 10580_Tthe_DyrkP -----VAGRYQIME--YL-GSAAFSKAIQCQDKQ---------------TGQMLCMKIIE 22423_Tthe_DyrkP -----IAGRYQVME--YL-GSAAFSKAIQCLDLV---------------TNRVMCMKIIE 5306_Tthe_DYRK2 -----IAYRYEIKE--FL-GKGSFGQVLKVFDHK---------------RKEYAALKVIR 5356_Tthe_DYRK2 -----IAYRYELIE--AL-GKGSFGQVIKVFDHK---------------RKEYSALKIIR 5655_Tthe_DYRK2 -----IAYRYELLE--CL-GKGSFGSVVKVFDHK---------------RKEFLALKVIR 15575_Tthe_PRP4 LN-----GKYRVIQ--KC-GKGVFANVCKAEQLD---------------NGKMVAIKILR DYRK1_Spur_DYRK1 -----WNDRYEIDS--LI-GKGSFGQVAKAYDHQ---------------EQEYVAIKIIK DYRK2_Spur_DYRK2 -----VAYRYEVLK--IL-GKGSFGQVVKVYDHK---------------TNQHIAVKMVR DYRK4_Spur_DYRK2 -----LAYRYEILE--VI-GKGSFGQVVKAFDHK---------------LGEMIAIKIIR HIPKa_Spur_HIPK LC--SLTNSYEVLE--FL-GRGTFGQVVKCWKRG---------------TNEIVAIKILK HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 LD-----KRYAVYG--YT-GQGVFSNVVRARDTAR--------------GKLDVAIKIIR CG7028_Dmel_PRP4 LD-----NRYLVNG--YT-GQGVFSNVVRGRDQAR--------------GQANVAIKIIR CC1G_13957_Ccin_DYRK2 -----LAYRYEVVD--TL-GKGSFGQVLNCRDHC---------------TGESVAVKIIR CC1G_04865_Ccin_PRP4 ID----NGRYQVFS--SL-GQGMFANVVRARVLKDENGKDLAVDGVAPESLREVAIKIIR CC1G_14245_Ccin_YAK LG-TEEGHKYLILD--IL-GQGTFGQVVKCQNMK---------------THEIVAVKVIK AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 -----WLDRYEIDS--LI-GKGSFGQVVKAFDLE---------------EREWVAIKVIK AqueK112_Aque_DYRK2 -----ISYRYEIRE--II-GKGSFGQVVKVFDHK---------------TNQHIALKIIR AqueK113_Aque_DYRK2 -----VSYRYEVLK--VL-GKGSFGQVLKAYDHK---------------MQTHIALKVVR AqueK114_Aque_HIPK IP--SPTSVYDVLD--RL-GRGTFGQVVRAWKKN---------------TSEIVAIKILK AqueK115_Aque_PRP4 LD-----RRYMVYG--YT-GQGVFSNVVRARDTSR--------------SSQEVAIKIIR AqueK116_Aque_PRP4 LD-----RRYMVYG--YT-GHGVFSNVVRARDTSR--------------SSQEVAIKIIR DYRK2_b_Smoe_DYRK2 -----IAYRYEILG--KL-GRGSFGQVLKCTDHK---------------YKVPRAIKIIR DYRK2_a_Smoe_DYRK2 -----IAYRYEILG--KL-GRGSFGQVLKCTDHK---------------YKVPRAIKIIR DYRKP-2_Smoe_DYRKP ----------------------------------------------------DVCMKIIK DYRKP-1_Smoe_DYRKP -----IAGRYHVTE--FL-GAAAFSKAIQAHDLF---------------TGMDVCMKIIK PRP4_e_Smoe_PRP4 IN-----SKYQVKA--SI-GSGMFSTVFLAKSLFP-------------ECEQEVAIKIPR PRP4_d_Smoe_PRP4 IN-----SKYQVKA--SI-GSGMFSTVFLAKSLLP-------------ECQQEVAIKIPR PRP4_b_Smoe_PRP4 LD-----NRYEIAS--SH-GRGVFSTVVRARDTKAGR-----------GEPEEVAIKIIR PRP4_a_Smoe_PRP4 LD-----NRYEIAS--SH-GRGVFSTVVRARDTKAGR-----------GEPEEVAIKIIR PRP4_c_Smoe_PRP4 IN-----SKYQVKA--SI-GSGMFSTVFLAKTLLP-------------ECEQEIAIKIPR YAK_b_Smoe_YAK IY--NPKHRYVVKE--ML-GQGTFGQVVKCWSDR---------------ENGYVAVKVIK YAK_a_Smoe_YAK IY--NPKHRYVVKE--ML-GQGTFGQVVKCWSDR---------------ENGYVAVKVIK YAK_d_Smoe_YAK ---------------------------------------------------GIVTRKTVD GK031_Glam_DYRK1 -----FNGRYCAER--PL-GQGSFGRVVLAKDTV---------------NNAYVAIKIMK GK034_Glam_DYRK2 -----IMYRYELVS--KL-GSGSFGKVYKALDHK---------------EQQFVALKIIK GK033_Glam_DYRK2 -----ILNRYKLLK--MV-GSATFSNVFSCLDLK---------------DNVTYCLKIIK GK032_Glam_DYRK2 -----LAGRYEIYK--TIFEDSAFSVTLKARDLK---------------EGKDVCLKVVN PRP4_Hsap_PRP4 NNELMQKTGLKELEFLKKLND-AD--PDD----KFHCLRLFRHFYHKQHLCLVFEPLSMN HIPK4_Hsap_HIPK NDAYRNRIIKNELKLLHCMRG-LDPE-------EAHVIRFLEFFHDALKFYLVFELLEQN HIPK3_Hsap_HIPK NHPSYARQGQIEVSILARLST-ENAD-------EYNFVRAYECFQHRNHTCLVFEMLEQN HIPK2_Hsap_HIPK NHPSYARQGQIEVSILARLST-ESAD-------DYNFVRAYECFQHKNHTCLVFEMLEQN HIPK1_Hsap_HIPK NHPSYARQGQIEVSILSRLSS-ENAD-------EYNFVRSYECFQHKNHTCLVFEMLEQN smi35A_Dmel_DYRK2 NKKRFLNQAVVELNILDELRE-KDAD--G----SHNVIHMLDYTYFRKHLCITFELMSLN mnb_Dmel_DYRK1 NKKPFLNQAQIEVKLLEMMNR-ADAE--N----KYYIVKLKRHFMWRNHLCLVFELLSYN Dyrk3_Dmel_DYRK2 NEKRFHRQAQEEIRILHHLRR-HDKY--N----TMNIIHMFDYFTFRNHTCITFELLSIN CG17090_Dmel_HIPK NHPSYARQGQIEVSILSRLSQ-ENAD-------EFNFVRAFECFQHKNHTCLVFEMLEQN PRP4_Mmus_PRP4 NNELMQKTGLKELEFLKKLND-AD--PDD----KFHCLRLFRHFYHKQHLCLVFEPLSMN HIPK4_Mmus_HIPK NDAYRSRIIKNELKLLRCVRG-LDPD-------EAHVIRFLEFFHDALKFYLVFELLEQN HIPK3_Mmus_HIPK NHPSYARQGQIEVSILARLST-ENAD-------EYNFVRAYECFQHRNHTCLVFEMLEQN HIPK2_Mmus_HIPK NHPSYARQGQIEVSILARLST-ESAD-------DYNFVRAYECFQHKNHTCLVFEMLEQN HIPK1_Mmus_HIPK NHPSYARQGQIEVSILSRLSS-ENAD-------EYNFVRSYECFQHKNHTCLVFEMLEQN DYRK4_Mmus_DYRK2 NKKRFHHQALVELKILEALRR-KDKD--N----NHNVVHMKDFFYFRNHLCITFELLGIN DYRK3_Mmus_DYRK2 NEKRFHRQAAEEIRILEHLKK-QDKT--G----SMNVIHMLESFTFRNHVCMAFELLSID DYRK2_Mmus_DYRK2 NEKRFHRQAAEEIRILEHLRK-QDKD--N----TMNVIHMLENFTFRNHICMTFELLSMN DYRK1B_Mmus_DYRK1 NKKAFLNQAQIELRLLELMNQ-HDTE--M----KYYIVHLKRHFMFRNHLCLVFELLSYN DYRK1A_Mmus_DYRK1 NKKAFLNQAQIEVRLLELMNK-HDTE--M----KYYIVHLKRHFMFRNHLCLVFEMLSYN mbk-2_Cele_DYRK2 NEKRFHRQADEEIRILDHLRR-QDSD--G----THNIIHMLDYFNFRNHKCITFELLSIN mbk-1_Cele_DYRK1 NKKTFFDQAQIEIHLLELTNA-HD--KDN----KYNIVTLKGHFVHRAHLCLVFELLSYN hpk-1_Cele_HIPK KHPSYARQGQIEVSILSRLSN-ENSE-------EFNFVRAFECFNHKSHTCLVFEMLEQN F22D6.5_Cele_PRP4 NNEVMYKTGLRELEVLRKLNE-AD--KED----KYHCLRLFRTFKHHNHLCLVFENLSMN C36B7.2_Cele_DYRK2 KLA---PRIYRETEMIMYISS-IDPD--H----TFDCVRMLDYNVFRGFHYVVTDLFDTS C36B7.1_Cele_DYRK2 RNL---STTYEETIILLRIHQ-LNRQ--N----NSNCVRMLDYDHFRGHHFIVLENYQTD DYRK4_Hsap_DYRK2 NKKRFHQQALMELKILEALRK-KDKD--N----TYNVVHMKDFFYFRNHFCITFELLGIN DYRK3_Hsap_DYRK2 NEKRFHRQAAEEIRILEHLKK-QDKT--G----SMNVIHMLESFTFRNHVCMAFELLSID DYRK2_Hsap_DYRK2 NEKRFHRQAAEEIRILEHLRK-QDKD--N----TMNVIHMLENFTFRNHICMTFELLSMN DYRK1B_Hsap_DYRK1 NKKAFLNQAQIELRLLELMNQ-HDTE--M----KYYIVHLKRHFMFRNHLCLVFELLSYN DYRK1A_Hsap_DYRK1 NKKAFLNQAQIEVRLLELMNK-HDTE--M----KYYIVHLKRHFMFRNHLCLVFEMLSYN YAK1_Scer_YAK SRTEYLTQSITEAKILELLNQKID--PTN----KHHFLRMYDSFVHKNHLCLVFELLSNN Dyrk1_Ddis_DYRK1 NKVPFYNQALIEIRLLELMNN-KD--PED----QYKIIKLKHHFKFRNHLCIVTELLSYN Dyrk2_Ddis_DYRK2 NQKRFHNQALTEIKILEYLKT-NDPN--S----TASIVHLNNYFYFRNHLILTFELLSMN Prp4_Ddis_PRP4 NRPSMHRSGLKEIEILQKISN-TPTSSNQ----KSHCIQMKDHFNYRNHLCIVFEPMSMS YakA_Ddis_YAK NKQAYFQQGRLEIQTLKSLNDQHD--PED----KNHILRLLDSFIHKMHLCIVFELLSVN 22349_Tthe_YAK NRPAYFQQAKNEILLLRVLNK-QE--EQNGENYQKRIVNLVDFFVFRNHFCLVFEMLELS 10580_Tthe_DyrkP NNKDYFDQSIDEIKLLKYINY-NGDV--D----EKNVLKVYDYFYHKEHLFIVTELLKDN 22423_Tthe_DyrkP NNKDYFDQSIDEIKLLRYINY-NGDV--D----EKNVLRYFDYFYHKEHLFIITELLEEN 5306_Tthe_DYRK2 NKQKFHEQALIELNILHYIKE-KDYD--N----QTNIVKIRDFVIFRNHVCLVFELLSIN 5356_Tthe_DYRK2 NKKNFYNQAIVELNILKYIKD-NDPQ--N----QTNIVKIKDFVIFRSHVGLL------- 5655_Tthe_DYRK2 NKKKFHNQALIELNILSYIKE-QDKD--E----ATNIVRIKDFVIFRKHVI--------- 15575_Tthe_PRP4 SNEIMRDSGEREKEIIQKLNL-ND--KND----RKHIVRLKNVFEHQKHMCLVFECFAMN DYRK1_Spur_DYRK1 NKKPFLNQAQIEVRLLELMNK-HDAD--S----KYYIVKLKRHFMFRNHLCLVFELLSYN DYRK2_Spur_DYRK2 NEKRFHRQAQEEIRILEHLRK-QDKD--N----NMNLIHMFESFSFRNHICITFELLSMN DYRK4_Spur_DYRK2 NKKRFHHQALIEVKILDALRR-KDRD--N----SHNVVHMREYFYYRNHLCITFELLGMN HIPKa_Spur_HIPK NHPSYARQGQIEVSILARLSA-ENAD-------DFNLVRAYEYFQHKNHTCLVFELLEKN HIPKb_Spur_HIPK ------------------------DD-------DYNSVAMYNNFPHKFHSCIIIELLERN PRP4_Spur_PRP4 NNDLMQKTGMKELEYLKRLND-QD--RED----KFHCVRLFRSFSYRQHLCLVFEPLSMN CG7028_Dmel_PRP4 NNEIMHKTGLRELEILKKLND-AD--PED----RFHCLRLYRHFFHKQHLCMVFEPLAMN CC1G_13957_Ccin_DYRK2 NKKRFHHQALVEIKILDNLRK-WDAD--E----KHHVLKMTEHFYFRNHLCIATELLSIN CC1G_04865_Ccin_PRP4 SQESMYKAGLKEAQILQKLRA-LD--PED----KKHIVKLERTFEHRGHLCLVFENLSMN CC1G_14245_Ccin_YAK NKPAYFNQSMMEVTILEMLNKTCD--PND----EHHLLRLRDSFIHRSHLCLVFELLSSN AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 NKRAFYQQALIEKRLLELLNS-RDPE--G----KYYIVSLKRSFTFRGHLCFVFELLSYN AqueK112_Aque_DYRK2 NKKRFHHQALVEVKILDSLRK-RDRD--N----QYNIIHMFDYFYFRNHLCITFELMGMN AqueK113_Aque_DYRK2 NEKRFHRQAQEEVKILEHLRR-QDKD--N----AHNIIHMIDHFTFRNHVCITFELLSMN AqueK114_Aque_HIPK STPSYAKQGQMEVDVLSKLSR-LSPD-------EGSFVKAYESFQHHGHICIVFELLHIN AqueK115_Aque_PRP4 NNEMMHKTGMAELEILKKLNA-TD--PDD----KFHCIRLFSNFFHKNHLCLVFESMSMN AqueK116_Aque_PRP4 NNEMMHKTGMAELEILKKLNA-TD--PDD----KFHCIRLFSNFFHKNHLCLVFESMSMN DYRK2_b_Smoe_DYRK2 NKKQFTQQAFIEINLLEFLRN-KAAEEGV----DYNIVTIYESFEFRGHLCLSFAVHDIS DYRK2_a_Smoe_DYRK2 NKKQFTQQAFIEINLLEFLRN-KAAEEGV----DYNIVTIYESFEFRGHLCLSFAVHDIS DYRKP-2_Smoe_DYRKP NNKDFFDQSLDEIKLLKYINK-HDPA--D----KYHILRLYDYFYHREHLFIVCELLRAN DYRKP-1_Smoe_DYRKP NNKDFFDQSLDEIKLLKYINK-HDPA--D----KYHILRLYDYFYHREHLFIVCELLRAN PRP4_e_Smoe_PRP4 KNDLMLRSAKSELQILKKVAE-PEAT-NK----DNHCVKLLDSFVYREHLCLVMESLDLN PRP4_d_Smoe_PRP4 KNDLMLRSAKSELQILKKVAE-PEAT-NK----DNHCVKLLDSFVYREHLCLVMEFLDLN PRP4_b_Smoe_PRP4 SNETMFKAGQMELIILNKLAG-AD--LEN----KRHCVRLLSSFEYRNHLCLVFESLHMN PRP4_a_Smoe_PRP4 SNETMFKAGQMELIILNKLAG-AD--LEN----KRHCVRLLSSFEYRNHLCLVFESLHMN PRP4_c_Smoe_PRP4 KNDLMLR-----------------------------------SAKYREHLCLVMESLDLN YAK_b_Smoe_YAK NQPAYYQQALVEIEILKMLNRDFD--PDN----QHHIVRILDWFLFEQHLCIAFELLSHN YAK_a_Smoe_YAK NQPAYYQQALVEIEILKMLNRDFD--PDN----QHHIVRILDWFLFEQHLCIAFELLSHN YAK_d_Smoe_YAK D----------------------------------------------------------- GK031_Glam_DYRK1 AGKLFTHKGREEAEIMSLLSD-EDPP--I----S---CKFIESFMQGNHYCIVMEALGSN GK034_Glam_DYRK2 NRKRFQRQGLVEVKILELLRD-NDPN--G----DQCCVKVLSSFYFRSHLCIAFELLSIN GK033_Glam_DYRK2 QEKEFFDQAIDEVHLLELLKD-IDPN--N----NINIIKIHDYFYFREHLLLKFTLLGED GK032_Glam_DYRK2 NEKDTLDQCLNEIRLLTYINK-HDPT--G-----KHFVRMTDYFYYGHRLIIIFELLTSN PRP4_Hsap_PRP4 LREVLKKYGKD-----------VGLHIKAVRSYSQQLFLALKLLK--RCNILHADIKPDN HIPK4_Hsap_HIPK LFEFQKE-NNF-----------APLPARHIRTVTLQVLTALARLK--ELAIIHADLKPEN HIPK3_Hsap_HIPK LYDFLKQ-NKF-----------SPLPLKVIRPILQQVATALKKLK--SLGLIHADLKPEN HIPK2_Hsap_HIPK LYDFLKQ-NKF-----------SPLPLKYIRPVLQQVATALMKLK--SLGLIHADLKPEN HIPK1_Hsap_HIPK LYDFLKQ-NKF-----------SPLPLKYIRPILQQVATALMKLK--SLGLIHADLKPEN smi35A_Dmel_DYRK2 LYELIKK-NNY-----------NGFSMSLIRRFCNSIVKCLRLLY--KENIIHCDLKPEN mnb_Dmel_DYRK1 LYDLLRN-TNF-----------RGVSLNLTRKFAQQLCTALLFLSTPELNIIHCDLKPEN Dyrk3_Dmel_DYRK2 LYELIKK-NGF-----------KGFSLQLVRKFAHSLLQCLDALY--KNDIIHCDMKPEN CG17090_Dmel_HIPK LYDFLKQ-NKF-----------SPLPLKYIRPILEQVLTALLKLK--QLGLIHADLKPEN PRP4_Mmus_PRP4 LREVLKKYGKD-----------VGLHIKAVRSYSQQLFLALKLLK--RCNILHADIKPDN HIPK4_Mmus_HIPK LFEFQKE-NNF-----------APLPARHIRTVTLQVLRALARLK--ELAIIHADLKPEN HIPK3_Mmus_HIPK LYDFLKQ-NKF-----------SPLPLKVIRPVLQQVATALKKLK--SLGLIHADLKPEN HIPK2_Mmus_HIPK LYDFLKQ-NKF-----------SPLPLKYIRPVLQQVATALMKLK--SLGLIHADLKPEN HIPK1_Mmus_HIPK LYDFLKQ-NKF-----------SPLPLKYIRPILQQVATALMKLK--SLGLIHADLKPEN DYRK4_Mmus_DYRK2 LYELMKN-NSF-----------HGFNLSIVRRFTFSILKCLHMLY--VEKIIHCDLKPEN DYRK3_Mmus_DYRK2 LYELIKK-NKF-----------QGFSVQLVRKFAQSILQSLDALH--KNKIIHCDLKPEN DYRK2_Mmus_DYRK2 LYELIKK-NKF-----------QGFSLPLVRKFAHSILQCLDALH--KNRIIHCDLKPEN DYRK1B_Mmus_DYRK1 LYDLLRN-THF-----------RGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPEN DYRK1A_Mmus_DYRK1 LYDLLRN-TNF-----------RGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPEN mbk-2_Cele_DYRK2 LYELIKR-NKF-----------QGFSLMLVRKFAYSMLLCLDLLQ--KNRLIHCDLKPEN mbk-1_Cele_DYRK1 LYDLLKN-TSF-----------RGVSLNLARKFAQQLGKTLLFLSSPELSIIHCDLKPEN hpk-1_Cele_HIPK LYDFLKQ-NKF-----------MPLPLNAIRPILFQVLTALLKLK--SLGLIHADLKPEN F22D6.5_Cele_PRP4 LRELLKKYGQK-----------DGLHLKAVRSYAQQLLLALRLLK--KLEFVHADIKPDN C36B7.2_Cele_DYRK2 VKKYIKE-HHPN-------G----IALENVAAMGRKILKGLVFLHE--HNIVHGDLKPEN C36B7.1_Cele_DYRK2 LASYLCGRSKLT--------------PREYIPMIKSIVHGLKFLHQ--NKIIHGDLKPAN DYRK4_Hsap_DYRK2 LYELMKN-NNF-----------QGFSLSIVRRFTLSVLKCLQMLS--VEKIIHCDLKPEN DYRK3_Hsap_DYRK2 LYELIKK-NKF-----------QGFSVQLVRKFAQSILQSLDALH--KNKIIHCDLKPEN DYRK2_Hsap_DYRK2 LYELIKK-NKF-----------QGFSLPLVRKFAHSILQCLDALH--KNRIIHCDLKPEN DYRK1B_Hsap_DYRK1 LYDLLRN-THF-----------RGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPEN DYRK1A_Hsap_DYRK1 LYDLLRN-TNF-----------RGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPEN YAK1_Scer_YAK LYELLKQ-NKF-----------HGLSIQLIRTFTTQILDSLCVLK--ESKLIHCDLKPEN Dyrk1_Ddis_DYRK1 LYDLLRN-THF-----------HGVSLNLIKKFAHQILTALFFMSTPEVDVIHCDLKPEN Dyrk2_Ddis_DYRK2 LYDFLKV-NHF-----------QGYNLNLVRRFGAQILTSLRFLS--KRNIIHADLKPEN Prp4_Ddis_PRP4 LHQLIKKYGKD-----------IGLSLNAVRVYAKQLFLALKHIK--NSKILHADIKPDN YakA_Ddis_YAK LFELIKQ-NNF-----------RGLSTNLIKVFLIQILDALIVLA--NANIIHCDLKPEN 22349_Tthe_YAK LYDYLKN-TKF-----------CGFSFSVIAQWTKSILEGMVIAE--SKQIIHCDLKPEN 10580_Tthe_DyrkP LYEFYKF-NREN-------ETQPYFTLGRLQKITQQILIGLDYIHS--LRLIHCDLKPEN 22423_Tthe_DyrkP LYEFYKF-NREN-------EQQRYFTVGRLQKITQQILVALDFIHS--LRLIHCDLKPEN 5306_Tthe_DYRK2 LYDLLRN-NKF-----------QGLSLELIRRFAIQLLNAISFLK--ENRIIHCDLKPEN 5356_Tthe_DYRK2 ------------------------------------------FLT--KANIIHCDLKPEN 5655_Tthe_DYRK2 -------------------------------------LNSINFLR--KNRIIHCDLKPEN 15575_Tthe_PRP4 LRDALKEYGKG-----------KGFSLDVVRSYAYQIFVALTHLK--KNNYIHADLKPDN DYRK1_Spur_DYRK1 LYDLLRN-TNF-----------RGVSLNLTRKFAQQMCTALLFLATPELNIIHCDLKPEN DYRK2_Spur_DYRK2 LYELIKK-NKF-----------QGFSLQLVRKFAHSLLQCLEGLH--RNKIIHCDLKPEN DYRK4_Spur_DYRK2 LYELIKK-NNF-----------QGFSVALIRRFAFSLLQCLRMLH--KERIIHCDLKPEN HIPKa_Spur_HIPK LYDFLKQ-SKF-----------RPLPLKHIRPTLQQVLVALLKLK--TLGLIHADLKPEN HIPKb_Spur_HIPK VYDLLLR-DAM-----------SSIPTPCVLPIYSFLCTVLVTLP--RLGQIYYDFDDSR PRP4_Spur_PRP4 LREVLKRYGKD-----------VGLHIKAVRSYTQQLFLALKLLK--RCNILHADIKPDN CG7028_Dmel_PRP4 LREVLKKYGKN-----------VGLHIKAVRSYTQQLFLALKLLK--KTGILHADIKPDN CC1G_13957_Ccin_DYRK2 LYELIKA-NGF-----------VGFTTALIRRFTTQMLMSLSLMR--HHRIVHCDLKPEN CC1G_04865_Ccin_PRP4 LREVVKRFGKD-----------VGLNIRAVRAYAHQLFLALSLLR--KANIMHADIKPDN CC1G_14245_Ccin_YAK LYELIKQ-NQF-----------QGLSTQLVKVFMAQLLDALTVLK--EARLIHCDLKPEN AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 LYELLRN-TNF-----------RGVSLNLTRKFAQQLCTALLFLSTHDINVIHCDLKPEN AqueK112_Aque_DYRK2 LYELIKK-NNF-----------QGFSISLIRRFAYSMLQCLKILY--RERIIHCDLKPEN AqueK113_Aque_DYRK2 LYELIKK-NKF-----------QGFSLALVRKFAHSILQCLDSLY--RNRIIHCDLKPEN AqueK114_Aque_HIPK LYDYLKQ-SRF-----------DPLPLKYIRPIAQQVLCCLEKLA--SLGLVHADLKPEN AqueK115_Aque_PRP4 IREVLRKYGKN-----------IGLHIKAVRSYSQQLLLALKLMK--RCTILHADIKPDN AqueK116_Aque_PRP4 IREVLRKYGKN-----------IGLHIKAVRSYSQQLLLALKLMK--RCTILHADIKPDN DYRK2_b_Smoe_DYRK2 LFDMLKK-NHF-----------EGFNLSLVKCFARQVLVSLQFLH--RARIIHGDLKPEN DYRK2_a_Smoe_DYRK2 LFDMLKK-NHF-----------EGFNLSLVKCFARQVLVSLQFLH--RARIIHGDLKPEN DYRKP-2_Smoe_DYRKP LYEFHKY-NRDS-------GGEVYFTMPRLQSITRQCLEALEFLHG--LGLIHCDLKPEN DYRKP-1_Smoe_DYRKP LYEFHKY-NRDS-------GGEVYFTMPRLQSITRQCLEALEFLHG--LGLIHCDLKPEN PRP4_e_Smoe_PRP4 LRQITNKYGRN-----------RGINLKTICVYAHQLMVALQHLA--HCGILHCDIKPDN PRP4_d_Smoe_PRP4 LRQITNKYGRN-----------RGINLKTICVYAHQLMVALQHLA--HCGILHCDIKPDN PRP4_b_Smoe_PRP4 LREILKKFGRN-----------IGISLAAVRSYARQLFTALKHLR--NCGVLHCDIKPDN PRP4_a_Smoe_PRP4 LREILKKFGRN-----------IGISLAAVRSYARQLFTALKHLR--NCGVLHCDIKPDN PRP4_c_Smoe_PRP4 LRQITNKYGRN-----------RGINLKTICVYAHQLMVALQHLA--HCGIFHCDIKPDN YAK_b_Smoe_YAK LYELIKV-NRH-----------RGISLHLLRIFTKQILDSLGVLR--NAGVIHCDLKPEN YAK_a_Smoe_YAK LYELIKV-NRH-----------RGISLHLLRIFTKQILDSLGVLR--NAGVIHCDLKPEN YAK_d_Smoe_YAK -----------------------------KMSIMTQLLEALQVLE--RHGVVHRDLKPEN GK031_Glam_DYRK1 LYHLLKS-TKMQ-------G----FPLQTIRVWARKYLTSFKKLQHESIRIIHTDCKPEN GK034_Glam_DYRK2 LYELLTK-KDL-----------KGLSLSLVRKFSLQLLIAFAYAR--KLRIIHADVKPEN GK033_Glam_DYRK2 LYTHFNR-REKK-------GQPNDYTIPVIRDMARQVLKALDYIH--RLGITHLDLKPEN GK032_Glam_DYRK2 LFSYYSA-REAALPRTLLNPLATIFTMPRLQHIARQILESLDFLHR--LNILHLDLKHEN PRP4_Hsap_PRP4 ILVNE-------SK--TILKLCDFGSASHVADN---DITPYLVSRF-------------- HIPK4_Hsap_HIPK IMLVDQ------TRCPFRVKVIDFGSASIFSEVRYV-KEPYIQSRF-------------- HIPK3_Hsap_HIPK IMLVDP------VRQPYRVKVIDFGSASHVSKTVC---STYLQSRY-------------- HIPK2_Hsap_HIPK IMLVDP------SRQPYRVKVIDFGSASHVSKAVC---STYLQSRY-------------- HIPK1_Hsap_HIPK IMLVDP------VRQPYRVKVIDFGSASHVSKAVC---STYLQSRY-------------- smi35A_Dmel_DYRK2 ILLKQR------GSS--SIKVIDFGSSCYVDRK-I---YTYIQSRF-------------- mnb_Dmel_DYRK1 ILLCNP------KRS--AIKIVDFGSSCQLGQR-I---YHYIQSRF-------------- Dyrk3_Dmel_DYRK2 VLLKQQ------GRS--GIKVIDFGSSCFENQR-I---YTYIQSRF-------------- CG17090_Dmel_HIPK IMLVDP------VRQPYRVKVIDFGSASHVSKTVC---NTYLQSRY-------------- PRP4_Mmus_PRP4 ILVNE-------SK--TILKLCDFGSASHVADN---DITPYLVSRF-------------- HIPK4_Mmus_HIPK IMLVDQ------TRCPFRVKVIDFGSASIFSEVRYV-KEPYIQSRF-------------- HIPK3_Mmus_HIPK IMLVDP------VRQPYRVKVIDFGSASHVSKTVC---STYLQSRY-------------- HIPK2_Mmus_HIPK IMLVDP------SRQPYRVKVIDFGSASHVSKAVC---STYLQSRY-------------- HIPK1_Mmus_HIPK IMLVDP------VRQPYRVKVIDFGSASHVSKAVC---STYLQSRY-------------- DYRK4_Mmus_DYRK2 IVLYQR------GQV--TVKVIDFGSSCYEHQK-V---YTYIQSRF-------------- DYRK3_Mmus_DYRK2 ILLKHH------GRS--ATKVIDFGSSCFEYQK-L---YTYIQSRF-------------- DYRK2_Mmus_DYRK2 ILLKQQ------GRS--SIKVIDFGSSCYEHQR-V---YTYIQSRF-------------- DYRK1B_Mmus_DYRK1 ILLCNP------KRS--AIKIVDFGSSCQLGQR-I---YQYIQSRF-------------- DYRK1A_Mmus_DYRK1 ILLCNP------KRS--AIKIVDFGSSCQLGQR-I---YQYIQSRF-------------- mbk-2_Cele_DYRK2 VLLKQQ------GRS--GIKVIDFGSSCFDDQR-I---YTYIQSRF-------------- mbk-1_Cele_DYRK1 VLLVNA------KR--SQIRVIDFGSSCQTGH----RIYQYIQSRF-------------- hpk-1_Cele_HIPK IMLVDP------QQQPYRVKVIDFGSASHRSKAVT---NTYLQSRY-------------- F22D6.5_Cele_PRP4 ILVNE-------SK--LTLKLCDFGSAGRVNEQ---ELAPYLVSRF-------------- C36B7.2_Cele_DYRK2 IMLNLA------N--PNDVKLGDFGLSRFAKPYHD---HVQCQSMF-------------- C36B7.1_Cele_DYRK2 VLLNEW------N--RNNLKLTDFGLSTFVNQGPF---FRDYQTLY-------------- DYRK4_Hsap_DYRK2 IVLYQK------GQA--SVKVIDFGSSCYEHQK-V---YTYIQSRF-------------- DYRK3_Hsap_DYRK2 ILLKHH------GRS--STKVIDFGSSCFEYQK-L---YTYIQSRF-------------- DYRK2_Hsap_DYRK2 ILLKQQ------GRS--GIKVIDFGSSCYEHQR-V---YTYIQSRF-------------- DYRK1B_Hsap_DYRK1 ILLCNP------KRS--AIKIVDFGSSCQLGQR-I---YQYIQSRF-------------- DYRK1A_Hsap_DYRK1 ILLCNP------KRS--AIKIVDFGSSCQLGQR-I---YQYIQSRF-------------- YAK1_Scer_YAK ILLCAP------DK--PELKIIDFGSSCEEAR----TVYTYIQSRF-------------- Dyrk1_Ddis_DYRK1 ILLRNP------KR--SAIKIIDFGSSCHSNE----RMYKYIQSRF-------------- Dyrk2_Ddis_DYRK2 ILLKSP------TKS--GIKLIDFGSSCFENEQ-I---FTYIQSRF-------------- Prp4_Ddis_PRP4 IVVNE-------AK--NTIKIVDFGSAGEIHES---EITPYLVSRF-------------- YakA_Ddis_YAK ILLQNV------NS--PAIKIIDFGSACYEKS----TLYTYIQSRH-------------- 22349_Tthe_YAK IMLKKQ------LI--LN-QTLKMAT-KFSQQ----K----------------------- 10580_Tthe_DyrkP ILMKSY------SK--CQVKIIDFGSSCFIHD-HL---SSYVQSRS-------------- 22423_Tthe_DyrkP ILMKSK------PK--GEVKVIDFGSSCFIHD-HL---SSYVQSRS-------------- 5306_Tthe_DYRK2 VLLKQP------NKS--GIKIADFGSSCFDDQV-M---YTYIQSRY-------------- 5356_Tthe_DYRK2 ILLKQE------NKS--GIKIVDFGSSCFENQR-V---YTYIQSRF-------------- 5655_Tthe_DYRK2 ILLKQA------NKS--GVKLIDFGSSCFENER-L---YTYIQSRY-------------- 15575_Tthe_PRP4 LLISE-------DT--KTLKMCDFGTALPIEEN---GIIKYLQSRF-------------- DYRK1_Spur_DYRK1 ILLCNP------KRS--AIKIIDFGSSCQLGQR-I---YQYIQSRF-------------- DYRK2_Spur_DYRK2 ILLKQQ------GRS--GIKVIDFGSSCYEHQR-I---YTYIQSRF-------------- DYRK4_Spur_DYRK2 ILLRQK------GQS--TIKVIDFGSSCYEHQR-V---YTYIQSRF-------------- HIPKa_Spur_HIPK IMLVDP------VRQPYRVKVIDFGSASHVSKAVC---STYLQSRY-------------- HIPKb_Spur_HIPK TLQCTP------SCQPFQNKFYETGTSVHVK-SQ----YSLCLQRS-------------- PRP4_Spur_PRP4 ILVNE-------SK--SVLKLCDFGSASHVADN---DITPYLVSRF-------------- CG7028_Dmel_PRP4 ILVNE-------NN--LILKLCDFGSASAISDN---EITPYLVSRF-------------- CC1G_13957_Ccin_DYRK2 VLLRHP------AKS--AIKVIDFGSSCLEHEK--------------------------- CC1G_04865_Ccin_PRP4 ILVNE-------QK--NLIKLCDLGSASDASEN---EITPYLVSRF-------------- CC1G_14245_Ccin_YAK ILLKSL------QS--PQIKVIDFGSACHERQ----TVYTYIQSRF-------------- AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ILLCNP------KRS--AIRIVDFGSSCQVGSR-M---FQYIQSRF-------------- AqueK112_Aque_DYRK2 ILLRLR------GQS--SIKVIDFGSSCYEHQR-V---YTYIQSRF-------------- AqueK113_Aque_DYRK2 ILLKQP------GRS--GIKVIDFGSSCYEYQR-V---YTYIQSRF-------------- AqueK114_Aque_HIPK IMLVDP------QRYPFKVKVIDFGSAMSRDKTSP---SCYLQSRY-------------- AqueK115_Aque_PRP4 ILVNE-------SK--LMLKLCDFGSASFIQDN---EITPYLVSRF-------------- AqueK116_Aque_PRP4 ILVNE-------SK--LMLKLCDFGSASFIQDN---EITPYLVSRF-------------- DYRK2_b_Smoe_DYRK2 ILLQQP------ASP--KIKLIDFGSSCFEHER-I---YTYIQSRF-------------- DYRK2_a_Smoe_DYRK2 ILLQQP------ASP--KIKLIDFGSSCFEHER-I---YTYIQSRF-------------- DYRKP-2_Smoe_DYRKP ILVKSY------SR--CEVKVIDLGSSCFQSD-HL---CSYVQSRS-------------- DYRKP-1_Smoe_DYRKP ILVKSY------SR--CEVKVIDLGSSCFQSD-HL---CSYVQSRS-------------- PRP4_e_Smoe_PRP4 IMVTK-------SR--RSIKLCDFGVAMFARDQTPSAETPYLVSPS-------------- PRP4_d_Smoe_PRP4 IMVTK-------SR--RSIKLCDFGVAMFARDQTPSAETPYLVSPS-------------- PRP4_b_Smoe_PRP4 MLVND-------SK--NLLKLCDFGSAMFAGEN---EITPYLVSRF-------------- PRP4_a_Smoe_PRP4 MLVND-------SK--NLLKLCDFGSAMFAGEN---EITPYLVSRF-------------- PRP4_c_Smoe_PRP4 IMVTK-------SR--RSIKLCDFGVAMFARDQTPSAETPYLVSPS-------------- YAK_b_Smoe_YAK ILLSTS------LKS-GEIKLIDFGSACLEHR----TVYKYIQFCNPSCYCEFTSLCALQ YAK_a_Smoe_YAK ILLSTS------LKS-GEIKLIDFGSACLEHR----TVYKYIQSRY-------------- YAK_d_Smoe_YAK IVLSS--------QG--ELRLIDFGSAVDSGR----EML--------------------- GK031_Glam_DYRK1 TLIPFN------NTCVEDIRIVDFGSAVRYPEGQM---FLYIQSRY-------------- GK034_Glam_DYRK2 ILLREP------DKS--SIKVIDWGSGAMVSET-I---YSYIQSRF-------------- GK033_Glam_DYRK2 LLHGDKNFIGGVNEP--SVTLVDFGSSSFIFDK-M---HSYIQSRS-------------- GK032_Glam_DYRK2 LLLVNE------DDDSFDIRLVDIGSSAFLYD-EC---STYVQSRS-------------- PRP4_Hsap_PRP4 YRAPEIIIGK-SYDYGIDMWSVGCTLYELYTGKILFPGKTNNH--------MLKLAMDLK HIPK4_Hsap_HIPK YRAPEILLGL-PFCEKVDVWSLGCVMAELHLGWPLYPGNNEYD--------QVRYICETQ HIPK3_Hsap_HIPK YRAPEIILGL-PFCEAIDMWSLGCVIAELFLGWPLYPGALEYD--------QIRYISQTQ HIPK2_Hsap_HIPK YRAPEIILGL-PFCEAIDMWSLGCVIAELFLGWPLYPGASEYD--------QIRYISQTQ HIPK1_Hsap_HIPK YRAPEIILGL-PFCEAIDMWSLGCVIAELFLGWPLYPGASEYD--------QIRYISQTQ smi35A_Dmel_DYRK2 YRSPEVILGL-QYGTAIDMWSLGCILAELYTGFPLFPGENEVE--------QLACIMEVL mnb_Dmel_DYRK1 YRSPEVLLGI-QYDLAIDMWSLGCILVEMHTGEPLFSGCNEVD--------QMNKIVEVL Dyrk3_Dmel_DYRK2 YRAPEVILGG-KYGRAIDMWSLGCILAELLSGHALFPGENESD--------QLACIIEVL CG17090_Dmel_HIPK YRAPEIILGL-PFCEAIDMWSLGCVVAELFLGWPLYPGSSEFD--------QIRYISQTQ PRP4_Mmus_PRP4 YRAPEIIIGK-SYDYGIDMWSVGCTLYELYTGKILFPGKTNNH--------MLKLAMDLK HIPK4_Mmus_HIPK YRAPEILLGL-PFCEKVDVWSLGCVMAELHLGWPLYPGNNEYD--------QVRYICETQ HIPK3_Mmus_HIPK YRAPEIILGL-PFCEAIDMWSLGCVIAELFLGWPLYPGALEYD--------QIRYISQTQ HIPK2_Mmus_HIPK YRAPEIILGL-PFCEAIDMWSLGCVIAELFLGWPLYPGASEYD--------QIRYISQTQ HIPK1_Mmus_HIPK YRAPEIILGL-PFCEAIDMWSLGCVIAELFLGWPLYPGASEYD--------QIRYISQTQ DYRK4_Mmus_DYRK2 YRSPEVILGH-PYNMAIDMWSLGCIMAELYTGYPLFPGENEVE--------QLACIMEVL DYRK3_Mmus_DYRK2 YRAPEIILGC-RYSTPIDIWSFGCILAELLTGQPLFPGEDEGD--------QLACMIELL DYRK2_Mmus_DYRK2 YRAPEVILGA-RYGMPIDMWSLGCILAELLTGYPLLPGEDEGD--------QLACMIELL DYRK1B_Mmus_DYRK1 YRSPEVLLGT-PYDLAIDMWSLGCILVEMHTGEPLFSGSNEVD--------QMSRIVEVL DYRK1A_Mmus_DYRK1 YRSPEVLLGM-PYDLAIDMWSLGCILVEMHTGEPLFSGANEVD--------QMNKIVEVL mbk-2_Cele_DYRK2 YRAPEVILGT-KYGMPIDMWSLGCILAELLTGYPLLPGEDEND--------QLALIIELL mbk-1_Cele_DYRK1 YRSPEVLLGI-AYDTKIDMWSLGCILVEMHTGEPLFAGSSEVD--------QMMKIVEVL hpk-1_Cele_HIPK YRAPEIILGL-PFNESIDMWSLGCVIAELFLGWPLYPGSSEYD--------QIRFIIQTQ F22D6.5_Cele_PRP4 YRAPEIMLGV-RHDYAIDLWSVAVTLYEVYTGKIMFPGRTNNH--------MLKLFTDVK C36B7.2_Cele_DYRK2 YRAPEAFVRG-RYNGATDMWSFGCTVAEMVSGKIFLAGDNCDD--------QFYLMQEVI C36B7.1_Cele_DYRK2 YKAPEVFCQG-KVSVEIDIWSLGCVAAEIVRGTPLFVGDNYFD--------QFALIQEFF DYRK4_Hsap_DYRK2 YRSPEVILGH-PYDVAIDMWSLGCITAELYTGYPLFPGENEVE--------QLACIMEVL DYRK3_Hsap_DYRK2 YRAPEIILGS-RYSTPIDIWSFGCILAELLTGQPLFPGEDEGD--------QLACMMELL DYRK2_Hsap_DYRK2 YRAPEVILGA-RYGMPIDMWSLGCILAELLTGYPLLPGEDEGD--------QLACMIELL DYRK1B_Hsap_DYRK1 YRSPEVLLGT-PYDLAIDMWSLGCILVEMHTGEPLFSGSNEVD--------QMNRIVEVL DYRK1A_Hsap_DYRK1 YRSPEVLLGM-PYDLAIDMWSLGCILVEMHTGEPLFSGANEVD--------QMNKIVEVL YAK1_Scer_YAK YRAPEIILGI-PYSTSIDMWSLGCIVAELFLGIPIFPGASEYN--------QLTRIIDTL Dyrk1_Ddis_DYRK1 YRSPEILLEL-EYSFSIDMWSLGCILVEMHVGEPLFSGQNEQD--------QLTKIIEVL Dyrk2_Ddis_DYRK2 YRSPEVILGT-KYDKSIDIWSLGCILVEIFTGVPLFPGSDEPE--------QLACIMEVL Prp4_Ddis_PRP4 YRAPEIILGH-KYDYSIDVWSVGCCLAEFFTGKFLFPGKTNND--------MIRLFMEYR YakA_Ddis_YAK YRSPEVLVGT-VYCASIDMWSLGCISAELFLGLPLFPGNSEYN--------QISRIVEMR 22349_Tthe_YAK --------WM-IYTTAIDMWSLGCILVELFLGLPIFPGNSEYD--------QIKRIIDIL 10580_Tthe_DyrkP YRAPEVILGC-KYDYKIDMWSLGCILAELWTGNVLFQNDTVQG--------LLARVIGII 22423_Tthe_DyrkP YRAPEVIIGC-KYDYRIDIWSLGCILAELWTGNVLFQNDNIQG--------LLARVIGII 5306_Tthe_DYRK2 YRSPEVILGI-PYGTEIDMWSFGCIIAELFLGYPIFPGEDENE--------QMGYIMELL 5356_Tthe_DYRK2 YRAPEIILGL-PYGKAIDMWSFGCIMAELYIGYPLFPGENEAE--------QFQMFMEIL 5655_Tthe_DYRK2 YRAPEVILGL-PYDTSIDMWSFGCIMAELFIGYPIFPGEDEQE--------QIGYIWEII 15575_Tthe_PRP4 YRAPEVLIGY-PPYNQIDVWSVGVTLYEIYTQKILFDGSTNNE--------MLKLIMDSR DYRK1_Spur_DYRK1 YRSPEVLLGI-SYDMAIDMWSLGCILVEMHTGEPLFSGSNELD--------QMNKIIEVL DYRK2_Spur_DYRK2 YRAPEVILGG-KYGMPIDMWSLGCILAELLTGYPLLPGEDEGD--------QLACMIEVM DYRK4_Spur_DYRK2 YRSPEVILGL-PYGLPIDMWSFGCILAELYTGYPLFPGENEVE--------QLACIMEIF HIPKa_Spur_HIPK YRCVKFLLSI-TLIEIVCMKSLSCVQTTFYVGWYMYVSFCIHV--------NVRYIIQVV HIPKb_Spur_HIPK CRAPEIILGL-PFCEAIDMWSLGCVVAELFLGWPLYPGASEYD--------QIRYISQTQ PRP4_Spur_PRP4 YRAPEIIIGM-NYDAAIDMWSTGCTIFELAAGKIMFPGKTNNH--------MLKLFMDLK CG7028_Dmel_PRP4 YRSPEIILGI-PYDYGIDTWSAGCTIYELYTGKILFSGKSNNQ--------MLKFFMDVK CC1G_13957_Ccin_DYRK2 --------------------------TELYTGFPIFPGENEQE--------QLSCIMEVL CC1G_04865_Ccin_PRP4 YRAPEIILGV-PYDPALDVWSIGCTLYELYTGKILFPGRSNNQ--------MLRLMMELK CC1G_14245_Ccin_YAK YRSPEVLLGM-PYTAAIDMWSLGCIAVELFLGLPLFPGTSEYN--------QLTRIIEML AqueK110_Aque_DYRK1 --------------------------------------------------------VEVL AqueK111_Aque_DYRK1 YRSPEVLLGI-PYDLAIDMWSLGCILVEMHTGEPLFSGKDEID--------QMSKIVEVL AqueK112_Aque_DYRK2 YRSPEVILGL-PYSMAIDMWSLGCILAELYTGYPLFPGENEVE--------QLACIIEIF AqueK113_Aque_DYRK2 YRAPEVILGG-KYGMSIDMWSFGCILAELLTGYPLFPGEDEGD--------QLACMMEVL AqueK114_Aque_HIPK YRAPEVILGV-NFNEGIDMWSLGCVLAELYLGWPLFPGASEFD--------QITYICQTL AqueK115_Aque_PRP4 YRAPE------------------------------------------------------- AqueK116_Aque_PRP4 YRAPEIIIGC-KYDYGIDMWSVGATLYELYTGQILFPGKSNNE--------MLKLNMELK DYRK2_b_Smoe_DYRK2 YRAPEVILGL-PYDMMIDVWSFACILAELFTGYPLFPGEDEVE--------QLAYMMEVL DYRK2_a_Smoe_DYRK2 YRAPEVILGL-PYDMMIDVWSFACILAELFTGYPLFPGEDEVE--------QLAYMMEVL DYRKP-2_Smoe_DYRKP YRAPEVILGL-PYDQKIDIWSLGCILAELCSGNVLFQNDSLAT--------LLARVVGII DYRKP-1_Smoe_DYRKP YRAPEVILGL-PYDQKIDIWSLGCILAELCSGNVLFQNDSLAT--------LLARVVGII PRP4_e_Smoe_PRP4 YRAPEIILGVAPYSHAIDMWSAGCCLYELYTGKFLFPVATNNG--------LLKQQMELK PRP4_d_Smoe_PRP4 YRAPEIILGVAPYSHPIDMWSAGCCLYELYTGKFLFPVATNNG--------LLKQQMELK PRP4_b_Smoe_PRP4 YRAPEIILGL-PYDHALDMWSVGCCLYELYTGKVLFPGSTNND--------MLRLHMELK PRP4_a_Smoe_PRP4 YRAPEIILGL-PYDHALDMWSVGCCLYELYTGKVLFPGSTNND--------MLRLHMELK PRP4_c_Smoe_PRP4 YRAPEIILGVAPYSHQIDMWSAGCCLYELYTGKFLFPVATNNG--------LLKQQMELK YAK_b_Smoe_YAK REAKEPLVGK-SYF---------------------------------------------- YAK_a_Smoe_YAK YRSPEVVLGH-PYTTAIDMWSLGCVAAELFLGLPLFSGESEYD--------LLRRMIDTL YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 YRAPEVLLLQ-PYDYQIDIWSIAAILFEMHTGKVLFPAKSSEI--------LCYMMVDIL GK034_Glam_DYRK2 YRAPEVILGL-PYGQEIDIWSIGCVLCELYTGLPIFPGDDERD--------QLGKICELL GK033_Glam_DYRK2 YRAPEVILAT-PYDSRADIWSFGCVVCELLTGRVLFPNYSVAT--------ILSRICSLI GK032_Glam_DYRK2 YRCPEVILGL-PYDGRADVWSLGPILTELITGKVMFPIPQKADEDHKPYASMLAKLIGII PRP4_Hsap_PRP4 GK-MPNKMIRKGVFKDQ------HFDQNL------------N-FM-------Y------- HIPK4_Hsap_HIPK GL-PKPHLLHAACKAHH------FFKRNP-------------HPD-------AA------ HIPK3_Hsap_HIPK GL-PGEQLLNVGTKSTR------FFCKET-------------DMS-------H------- HIPK2_Hsap_HIPK GL-PAEYLLSAGTKTTR------FFNRDT-------------DSP-------Y------- HIPK1_Hsap_HIPK GL-PAEYLLSAGTKTTR------FFNRDP-------------NLG-------Y------- smi35A_Dmel_DYRK2 GL-PPKVLISVARRRRL------FFDSRD------------A-PR-------CI------ mnb_Dmel_DYRK1 GM-PPKYLLDQAHKTRK------FFDKIV------------ADGS-------Y------- Dyrk3_Dmel_DYRK2 GM-PNKNILASSKRSKS------FFSPKG------------Y-PR-------YC------ CG17090_Dmel_HIPK GL-PTEHMLNSASKTSK------FFYRDV-------------DST-------Y------- PRP4_Mmus_PRP4 GK-MPNKMIRKGVFKDQ------HFDQNL------------N-FM-------Y------- HIPK4_Mmus_HIPK GL-PKPHLLHAARKAHH------FFKRNP-------------HPD-------AT------ HIPK3_Mmus_HIPK GL-PGEQLLNVGTKSTR------FFCRET-------------DMS-------H------- HIPK2_Mmus_HIPK GL-PAEYLLSAGTKTTR------FFNRDT-------------DSP-------Y------- HIPK1_Mmus_HIPK GL-PAEYLLSAGTKTTR------FFNRDP-------------NLG-------Y------- DYRK4_Mmus_DYRK2 GL-PPAHFTQTASRRQV------FFDSKG------------L-PK-------NI------ DYRK3_Mmus_DYRK2 GM-PPQKLLEQSKRAKY------FINSKG------------L-PR-------YC------ DYRK2_Mmus_DYRK2 GM-PSQKLLDASKRAKN------FVSSKG------------Y-PR-------YC------ DYRK1B_Mmus_DYRK1 GI-PPAPMLEQAPKARK------YFERLP-------------GGG-------W------- DYRK1A_Mmus_DYRK1 GI-PPAHILDQAPKARK------FFEKLP-------------DGT-------W------- mbk-2_Cele_DYRK2 GM-PPPKSLETAKRART------FITSKG------------Y-PR-------YC------ mbk-1_Cele_DYRK1 GM-PPKEMLDIGPKTHK------YFDKTE------------D-GI--------------- hpk-1_Cele_HIPK GL-PPTSMLESASKLHR------FFKEVK-------------SESPNHTNVGG------- F22D6.5_Cele_PRP4 GK-YPNKLVRKSQFKDT------HFDVNC------------N-LL-------Y------- C36B7.2_Cele_DYRK2 NI-PPPVFFDTFYTNYY------FFSTLK------------EAPK-------HI------ C36B7.1_Cele_DYRK2 GK-PSRKLFNTWGGIHQ------FYTEYF-------------FPR-------HC------ DYRK4_Hsap_DYRK2 GL-PPAGFIQTASRRQT------FFDSKG------------F-PK-------NI------ DYRK3_Hsap_DYRK2 GM-PPPKLLEQSKRAKY------FINSKG------------I-PR-------YC------ DYRK2_Hsap_DYRK2 GM-PSQKLLDASKRAKN------FVSSKG------------Y-PR-------YC------ DYRK1B_Hsap_DYRK1 GI-PPAAMLDQAPKARK------YFERLP-------------GGG-------W------- DYRK1A_Hsap_DYRK1 GI-PPAHILDQAPKARK------FFEKLP-------------DGT-------W------- YAK1_Scer_YAK GY-PPSWMIDMGKNSGK------FMKKLA--------------PE-------ESS----- Dyrk1_Ddis_DYRK1 DL-PPSHMIDSSPKAKK------FFTKDP------------I-NS--------------- Dyrk2_Ddis_DYRK2 GA-PPKSVIDNSTRKDI------FFEDDG------------T-PK--------------- Prp4_Ddis_PRP4 GA-FSKKMLKKSEFVSN------HFNENL------------V-FM-------K------- YakA_Ddis_YAK GI-FPSDLLDKGKSSTR------YFHRHL------------G-SN-------SDDNNNNN 22349_Tthe_YAK GK-PTNEVIEQGRFKNK------FFKCLD------------G------------------ 10580_Tthe_DyrkP GP-IPEWMFQEGRLVNN------FFTNKR-------------LLY-------QD------ 22423_Tthe_DyrkP GP-FPEWMMKEGRLVQN------FFTREK-------------LLY-------ME------ 5306_Tthe_DYRK2 GA-PDSEFLKKCSRKKY------FFDQND------------Q-PL-------QI------ 5356_Tthe_DYRK2 GI-PEEEFVENCPRRNV------FFENNK------------T-PK-------VV------ 5655_Tthe_DYRK2 GA-PSKDFLQNCTRRKY------FFNEDY------------T-PK-------LI------ 15575_Tthe_PRP4 GK-FNKKMLQNGKYVEE------YFDQNY------------N-FK-------Y------- DYRK1_Spur_DYRK1 GM-PPNHIIEQAPKAHK------YFIKTE-------------K-T-------W------- DYRK2_Spur_DYRK2 GM-PSQNLIDTSKRSKN------FINSKG------------Q-PR-------YC------ DYRK4_Spur_DYRK2 GL-PPPHIIEEAQRRRL------FFEDSS------------A-PD-------VS------ HIPKa_Spur_HIPK AL-PGLSHLNLKNKSAD------FSIRGT-------------TMS-------S------- HIPKb_Spur_HIPK GL-PAEHLLSAATKTTR------FFKRDI-------------ESN-------F------- PRP4_Spur_PRP4 GK-MPHKIIRKGILRDK------HFDPNC------------N-FK-------Y------- CG7028_Dmel_PRP4 GK-IPNRIIRKGQFREQ------HFDQSC------------N-FL-------Y------- CC1G_13957_Ccin_DYRK2 GV-PDKEYINRSSRKKL------FFDTNG------------A-PR--------------- CC1G_04865_Ccin_PRP4 GR-FNTKIIKKAKFGET------YFDELG------------A-FE-------S------- CC1G_14245_Ccin_YAK GM-PPLSMLNSGKQTKL------------------------------------------- AqueK110_Aque_DYRK1 GI-PPPHVLERSARRDR------FFERES-------------GGT-------W------- AqueK111_Aque_DYRK1 GI-PPPHVLERSARRDR------FFERES-------------GGT-------W------- AqueK112_Aque_DYRK2 GL-PDPALLAEAQRKKL------FFDSRG------------N-PR-------CV------ AqueK113_Aque_DYRK2 GL-PSQKMIESTKRGRT------FFSSKG------------H-PR-------YT------ AqueK114_Aque_HIPK GP-LPHHLMRNITKATR------FFNCDP-------------VTS--------------- AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 GK-MSHKMVRKGMFREN------HFDSSF------------N-FL-------Y------- DYRK2_b_Smoe_DYRK2 GT-PPLSLISQAKRKKM------FFDSDN------------K-PR-------IV------ DYRK2_a_Smoe_DYRK2 GT-PPLSLISQAKRKKM------FFDSDN------------K-PR-------IV------ DYRKP-2_Smoe_DYRKP GP-LDPEMVARGRESYK------FLTKNS-------------KLY-------ER------ DYRKP-1_Smoe_DYRKP GP-LDPEMVARGRESYK------FLTKNG-------------KLY-------ER------ PRP4_e_Smoe_PRP4 GA-FPKAMLKKGAFTGM------HFNENF------------E-FR-------Q------- PRP4_d_Smoe_PRP4 GA-FPKAMLKKGAFTGM------HFNENF------------E-FR-------Q------- PRP4_b_Smoe_PRP4 GP-FPKKMLRKAMFTAQ------HFDQDL------------N-FH-------A------- PRP4_a_Smoe_PRP4 GP-FPKKMLRKAMFTAQ------HFDQDL------------N-FH-------A------- PRP4_c_Smoe_PRP4 GA-FPKAMLKKGAFTGM------HFNENF------------E-FR-------Q------- YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK GCQPPDQLLRDSANTSK------YFKTVS------------A-AP-------PSS----- YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 GY-PPKEMIMDEEQKQISNSLKRYFKMRKQEDAELFHLNENAFPH-------QV------ GK034_Glam_DYRK2 GM-PPNDMIFKSPRKND------FFVNIG------------T-GM-------G------- GK033_Glam_DYRK2 GP-IPRDMIMSGRMGQR------VLTFGL------------V-P--------Y------- GK032_Glam_DYRK2 GP-IPRDMILAGRESHK------LFTKDL-------------FLF-------ET------ PRP4_Hsap_PRP4 ---------IEVDKVTERE-----------------------------------K----- HIPK4_Hsap_HIPK ------N-PWQLKSSADY------------------------------------------ HIPK3_Hsap_HIPK ------S-GWRLKTLEEH------------------------------------------ HIPK2_Hsap_HIPK ------P-LWRLKTPDDH------------------------------------------ HIPK1_Hsap_HIPK ------P-LWRLKTPEEH------------------------------------------ smi35A_Dmel_DYRK2 --------T--NT----------------------------------------------- mnb_Dmel_DYRK1 ----------VLKKNQNG------------------------------------------ Dyrk3_Dmel_DYRK2 --------T--VRTMSDGMVVLIG-----------------------------GQ-SR-- CG17090_Dmel_HIPK ------P-FWRLKTTEEH------------------------------------------ PRP4_Mmus_PRP4 ---------IEVDKVTERE-----------------------------------K----- HIPK4_Mmus_HIPK ------N-PWQLKSSADY------------------------------------------ HIPK3_Mmus_HIPK ------S-GWRLKTLEEH------------------------------------------ HIPK2_Mmus_HIPK ------P-LWRLKTPDDH------------------------------------------ HIPK1_Mmus_HIPK ------P-LWRLKTPEEH------------------------------------------ DYRK4_Mmus_DYRK2 --------N--NN----------------------------------------------- DYRK3_Mmus_DYRK2 --------S--VSTQTDGRVVLLG-----------------------------GR-SR-- DYRK2_Mmus_DYRK2 --------T--VTTLSDGSVVLNG-----------------------------GR-SR-- DYRK1B_Mmus_DYRK1 ----------TLRRTKEL------------------------------------------ DYRK1A_Mmus_DYRK1 ----------SLKKTKDG------------------------------------------ mbk-2_Cele_DYRK2 --------T--ATSMPDGSVVLAG-----------------------------AR-SK-- mbk-1_Cele_DYRK1 ---------YYCKKTRDGY-----------------------------------R----- hpk-1_Cele_HIPK ------S-YYRLKTVEEY------------------------------------------ F22D6.5_Cele_PRP4 ---------QEVDKVTERN-----------------------------------K----- C36B7.2_Cele_DYRK2 --------V----ITDHG-----P------------IV-------SF-----IYT-KA-- C36B7.1_Cele_DYRK2 --------F-EWLNPFNG-----D------------RT------MEIEP---HYK-LA-- DYRK4_Hsap_DYRK2 --------T--NN----------------------------------------------- DYRK3_Hsap_DYRK2 --------S--VTTQADGRVVLVG-----------------------------GR-SR-- DYRK2_Hsap_DYRK2 --------T--VTTLSDGSVVLNG-----------------------------GR-SR-- DYRK1B_Hsap_DYRK1 ----------TLRRTKEL------------------------------------------ DYRK1A_Hsap_DYRK1 ----------NLKKTKDG------------------------------------------ YAK1_Scer_YAK ---SSTQ-KHRMKTIEEFC-----------------------------------R----- Dyrk1_Ddis_DYRK1 --------TYQLKKNEKLK-----------------------------------T----- Dyrk2_Ddis_DYRK2 ----------PVKNSTTG------------------------------------------ Prp4_Ddis_PRP4 ---------QEIDNIEKTV-----------------------------------R----- YakA_Ddis_YAK NNNNGKPYYYTLKSEEDYQ-----------------------------------R----- 22349_Tthe_YAK --------EYIFKTKQEFE-----------------------------------I----- 10580_Tthe_DyrkP --------VFEEGEPSQN------------------IND----TSDMPGR-R-QK-SG-- 22423_Tthe_DyrkP --------VFEEADQSQA------------------IGD----QQDGQRQ-K-IK-TG-- 5306_Tthe_DYRK2 --------P--NS----------------------------------------------- 5356_Tthe_DYRK2 --------K--NS----------------------------------------------- 5655_Tthe_DYRK2 --------P--NS----------------------------------------------- 15575_Tthe_PRP4 ---------TYVDKQTNQK-----------------------------------Y----- DYRK1_Spur_DYRK1 ----------VLKRSRDG------------------------------------------ DYRK2_Spur_DYRK2 --------T--VTTLPDGTTVLNG-----------------------------GR-SR-- DYRK4_Spur_DYRK2 --------K--KN----------------------------------------------- HIPKa_Spur_HIPK ------S-TWLLKACSKR------------------------------------------ HIPKb_Spur_HIPK ------P-LWRLKNPEEH------------------------------------------ PRP4_Spur_PRP4 ---------VEVDKVTERE-----------------------------------K----- CG7028_Dmel_PRP4 ---------HEIDKLTERE-----------------------------------K----- CC1G_13957_Ccin_DYRK2 ----------PVVNSK-G------------------------------------------ CC1G_04865_Ccin_PRP4 ---------VERDRLTGSD-----------------------------------I----- CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ----------VLKRQRDG------------------------------------------ AqueK111_Aque_DYRK1 ----------VLKRQRDG------------------------------------------ AqueK112_Aque_DYRK2 --------T--NS----------------------------------------------- AqueK113_Aque_DYRK2 --------T--VNINPDGTASYTG-----------------------------GR-SR-- AqueK114_Aque_HIPK --------TWSLKSISQY------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ---------HTVDKVTQKE-----------------------------------K----- DYRK2_b_Smoe_DYRK2 --------P--NS----------------------------------------------- DYRK2_a_Smoe_DYRK2 --------P--NS----------------------------------------------- DYRKP-2_Smoe_DYRKP --------N--------------------------------------------QE-TS-- DYRKP-1_Smoe_DYRKP --------N--------------------------------------------QE-TS-- PRP4_e_Smoe_PRP4 -----------LDPVTKLE-----------------------------------T----- PRP4_d_Smoe_PRP4 -----------LDPVTKLE-----------------------------------T----- PRP4_b_Smoe_PRP4 ---------IEEDPVTKK------------------------------------------ PRP4_a_Smoe_PRP4 ---------IEEDPVTKKV-----------------------------------Q-FCIF PRP4_c_Smoe_PRP4 -----------LDPVTKLE-----------------------------------T----- YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ---GGMA-VYQFLTVSEVK-----------------------------------A----- YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 --------V-PDSYLLNK-----S------------VIE----MAEAQKE-RIFGRPL-- GK034_Glam_DYRK2 ----------VAGVSEGG-----NPIFSGNLQQLSSVNEYLQATGRGAGG-SEVP-GI-- GK033_Glam_DYRK2 ------------EHDEKN------------------------------------------ GK032_Glam_DYRK2 --------R----EAILG------------------NRD----KAEGLRHAE-IK-GE-- PRP4_Hsap_PRP4 --------------VT-VMS---T-INPT-KDLLAD------------------------ HIPK4_Hsap_HIPK -----------L-AET-KVRPLER-RKY-MLKSLDQ------------------------ HIPK3_Hsap_HIPK -----------E-AET-GMKSKEA-RKY-IFNSLDD------------------------ HIPK2_Hsap_HIPK -----------E-AET-GIKSKEA-RKY-IFNCLDD------------------------ HIPK1_Hsap_HIPK -----------E-LET-GIKSKEA-RKY-IFNCLDD------------------------ smi35A_Dmel_DYRK2 -----------KG-R-KR--SPGS-K------SLAH------------------------ mnb_Dmel_DYRK1 -----------R--K-Y--KPPGS-R------KLHD------------------------ Dyrk3_Dmel_DYRK2 -----------RG-K-QR-GPPCS-K------SLSK------------------------ CG17090_Dmel_HIPK -----------E-AET-NTKSKEA-RKY-IFNCLDD------------------------ PRP4_Mmus_PRP4 --------------VT-VMS---T-INPT-KDLLAD------------------------ HIPK4_Mmus_HIPK -----------L-AET-KVRPLER-RKY-MLKSLDQ------------------------ HIPK3_Mmus_HIPK -----------E-AET-GMKSKEA-RKY-IFNSLDD------------------------ HIPK2_Mmus_HIPK -----------E-AET-GIKSKEA-RKY-IFNCLDD------------------------ HIPK1_Mmus_HIPK -----------E-LET-GIKSKEA-RKY-IFNCLDD------------------------ DYRK4_Mmus_DYRK2 -----------RG-G-KR--YPDS-K------DLTM------------------------ DYRK3_Mmus_DYRK2 -----------RG-K-KR-GPPGS-K------DWAT------------------------ DYRK2_Mmus_DYRK2 -----------RG-K-LR-GPPES-R------EWGN------------------------ DYRK1B_Mmus_DYRK1 -----------R-KD-Y--QGPGT-R------RLQE------------------------ DYRK1A_Mmus_DYRK1 -----------K-RE-Y--KPPGT-R------KLHN------------------------ mbk-2_Cele_DYRK2 -----------RG-K-MR-GPPAS-R------SWST------------------------ mbk-1_Cele_DYRK1 --------------HT--YKAPG-------ARKLHE------------------------ hpk-1_Cele_HIPK -----------E-ASSSTAKSKET-RKY-IFNVIDD------------------------ F22D6.5_Cele_PRP4 --------------IT-VLA---N-LKPT-RDLESE------------------------ C36B7.2_Cele_DYRK2 -----------AD-H-R--KIPGA-T------PIGS------------------------ C36B7.1_Cele_DYRK2 -----------HP-S-R--KPPLT-S------SLVS------------------------ DYRK4_Hsap_DYRK2 -----------RG-K-KR--YPDS-K------DLTM------------------------ DYRK3_Hsap_DYRK2 -----------RG-K-KR-GPPGS-K------DWGT------------------------ DYRK2_Hsap_DYRK2 -----------RG-K-LR-GPPES-R------EWGN------------------------ DYRK1B_Hsap_DYRK1 -----------R-KD-Y--QGPGT-R------RLQE------------------------ DYRK1A_Hsap_DYRK1 -----------K-RE-Y--KPPGT-R------KLHN------------------------ YAK1_Scer_YAK --------------EY-NIVEKPS-KQYFKWRKLPD------------------------ Dyrk1_Ddis_DYRK1 -----------------------N-VEFC-KKKLSE------------------------ Dyrk2_Ddis_DYRK2 -----------E----L--YTIGT-K------SFKD------------------------ Prp4_Ddis_PRP4 ------------KVPH-DIT---K---PT-KDILQF------------------------ YakA_Ddis_YAK --------------DS-KTTLLPS-KKYFNYKTLPE------------------------ 22349_Tthe_YAK --------------SE-GIQLKES-KTYFQVACLND------------------------ 10580_Tthe_DyrkP -----------KI-Q-I--LVPKK-S------NLRA------------------------ 22423_Tthe_DyrkP -----------KI-Q-I--LVPKH-S------NLKA------------------------ 5306_Tthe_DYRK2 -----------RG-K-IR--MPNS-K------NWKS------------------------ 5356_Tthe_DYRK2 -----------RG-K-IR--TPAT-K------HINY------------------------ 5655_Tthe_DYRK2 -----------KG-K-IR--VPNS-K------ILKA------------------------ 15575_Tthe_PRP4 --------------TT-IIT---YGDIPK-KDIYRL------------------------ DYRK1_Spur_DYRK1 -----------K--K-Y--KSPRT-R------KLQD------------------------ DYRK2_Spur_DYRK2 -----------RG-K-VR-GPPGS-K------DLVK------------------------ DYRK4_Spur_DYRK2 ------------G-L-RI--SREK-S------NLNAKSDFVMPPIHLGINADLTAEKPVN HIPKa_Spur_HIPK -----------P-SET-GVSD-SR-SNY-LFNTIND------------------------ HIPKb_Spur_HIPK -----------E-TET-SVKSKEA-RKY-IFNCLDD------------------------ PRP4_Spur_PRP4 --------------VT-VMT---V-INPT-KDLTTE------------------------ CG7028_Dmel_PRP4 --------------IV-VMP---V-VKPS-RSLQQE------------------------ CC1G_13957_Ccin_DYRK2 -----------R----R--RRPGS-K------TLAQ------------------------ CC1G_04865_Ccin_PRP4 --------------TR-KIH---I-QKPT-RDLRAR------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 -----------R-KDHH--RRPGS-R------SLYE------------------------ AqueK111_Aque_DYRK1 -----------R-KDHH--RRPGS-R------SLYE------------------------ AqueK112_Aque_DYRK2 -----------KG-K-KR--RPGS-K------DLSS------------------------ AqueK113_Aque_DYRK2 -----------RG-K-FR-GPPGT-K------DMSR------------------------ AqueK114_Aque_HIPK -----------T-QET-GIQSKES-RKY-IFRSLLD------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 --------------VV-VMS---S-FSPQ-RDLLAD------------------------ DYRK2_b_Smoe_DYRK2 -----------SG-T-RH--FPST-K------DLRM------------------------ DYRK2_a_Smoe_DYRK2 -----------SG-T-RH--FPST-K------DLRM------------------------ DYRKP-2_Smoe_DYRKP -----------RM-E-Y--LIPKK-T------TLAH------------------------ DYRKP-1_Smoe_DYRKP -----------RM-E-Y--LIPKK-T------TLAH------------------------ PRP4_e_Smoe_PRP4 --------------LR-SMA---S-FNVK-TSCISD------------------------ PRP4_d_Smoe_PRP4 --------------LR-SMA---S-FNVK-TSCISD------------------------ PRP4_b_Smoe_PRP4 ------------TINR-MIT---N-V-KP-KDI-ST------------------------ PRP4_a_Smoe_PRP4 PVYSFLHLLSFQTINR-MIT---N-V-KP-KDI-ST------------------------ PRP4_c_Smoe_PRP4 --------------LR-SMA---S-FNVK-TSCLSD------------------------ YAK_b_Smoe_YAK -----------------------------RHTKLED------------------------ YAK_a_Smoe_YAK --------------RE-SKEPLVG-KSYFRHTKLED------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 -----------RE-L-I--RNPVM-T------QYE------------------------- GK034_Glam_DYRK2 -----------RLRT-T--HKVNS-K------TLSG------------------------ GK033_Glam_DYRK2 -----------R-QHFY--FTPQQ-G------LLEY------------------------ GK032_Glam_DYRK2 -----------DY-V-Y--VLPKK-T------TIKA------------------------ PRP4_Hsap_PRP4 ----LIGC---------------QRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQ--- HIPK4_Hsap_HIPK ----IETVN-GGSVASRLTFPDRE--ALAEHADLKSMVELIKRMLTWESHERISPSA--- HIPK3_Hsap_HIPK ----VAHVN-TV---MD--LEGSD--LLAEKADRREFVSLLKKMLLIDADLRITPAE--- HIPK2_Hsap_HIPK ----MAQVN-MT---TD--LEGSD--MLVEKADRREFIDLLKKMLTIDADKRITPIE--- HIPK1_Hsap_HIPK ----MAQVN-MS---TD--LEGTD--MLAEKADRREYIDLLKKMLTIDADKRITPLK--- smi35A_Dmel_DYRK2 ---------------------------IL-HCQDRYFIDFLQRCLEWDPAERMTPDE--- mnb_Dmel_DYRK1 ----ILGVET-GGP-GG--RRLDE--PGHSVSDYLKFKDLILRMLDFDPKTRVTPYY--- Dyrk3_Dmel_DYRK2 ---------------------------ALDGCKDPLFLNFIRGCLEWDADKRLTPSE--- CG17090_Dmel_HIPK ----IGQVN-VP---TD--LEGGQ--LLAEKTDRREFIDLLKRMLTIDQERRLTPAE--- PRP4_Mmus_PRP4 ----LIGC---------------QRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQ--- HIPK4_Mmus_HIPK ----IETVN-GGGAVSRLSFPDRE--ALAEHADLKSMVELIKRMLTWESHERISPSA--- HIPK3_Mmus_HIPK ----IVHVN-TV---MD--LEGGD--LLAEKADRREFVNLLKKMLLIDADLRITPIE--- HIPK2_Mmus_HIPK ----MAQVN-MT---TD--LEGSD--MLVEKADRREFIDLLKKMLTIDADKRVTPIE--- HIPK1_Mmus_HIPK ----MAQVN-MS---TD--LEGTD--MLAEKADRREYIDLLKKMLTIDADKRITPLK--- DYRK4_Mmus_DYRK2 ---------------------------VV-KTYDSSFLDFLRRCLVWEPSLRMTPEQ--- DYRK3_Mmus_DYRK2 ---------------------------ALKGCGDYLFIEFLKRCLQWDPSARLTPAQ--- DYRK2_Mmus_DYRK2 ---------------------------ALKGCDDPLFLDFLKQCLEWDPAVRMTPGQ--- DYRK1B_Mmus_DYRK1 ----VLGVQT-GGP-GG--RRAGE--PGHSPADYLRFQDLVLRMLEYEPAARISPLG--- DYRK1A_Mmus_DYRK1 ----ILGVET-GGP-GG--RRAGE--SGHTVADYLKFKDLILRMLDYDPKTRIQPYY--- mbk-2_Cele_DYRK2 ---------------------------ALKNMGDELFVDFLKRCLDWDPETRMTPAQ--- mbk-1_Cele_DYRK1 ----ILGVTS-GGP-GG--RRLGE--PGHSVEDYSKFKDLIKRMLQFDPKQRISPYY--- hpk-1_Cele_HIPK ----ISRVC-YG---FE--SDPVE--HLCDRIDRQEFVDVLKKMLVLNPDFRITPAE--- F22D6.5_Cele_PRP4 ----LIAG---------------QRLSRDQMDQIQAFRTLLDGMLILDPSKRTTCNE--- C36B7.2_Cele_DYRK2 ----F-----------------------FTKTEQKPFNNFILKVFKWMPASRITAKQ--- C36B7.1_Cele_DYRK2 ----K-----------------------LPGGNQKFLARFLMRCFEWDPTERIKSSF--- DYRK4_Hsap_DYRK2 ---------------------------VL-KTYDTSFLDFLRRCLVWEPSLRMTPDQ--- DYRK3_Hsap_DYRK2 ---------------------------ALKGCDDYLFIEFLKRCLHWDPSARLTPAQ--- DYRK2_Hsap_DYRK2 ---------------------------ALKGCDDPLFLDFLKQCLEWDPAVRMTPGQ--- DYRK1B_Hsap_DYRK1 ----VLGVQT-GGP-GG--RRAGE--PGHSPADYLRFQDLVLRMLEYEPAARISPLG--- DYRK1A_Hsap_DYRK1 ----ILGVET-GGP-GG--RRAGE--SGHTVADYLKFKDLILRMLDYDPKTRIQPYY--- YAK1_Scer_YAK ----IIRNY--RYP-KS--IQNSQELIDQEMQNRECLIHFLGGVLNLNPLERWTPQQ--- Dyrk1_Ddis_DYRK1 ----IIGVET-GGP-QS--RRKNE--PGHALVDYLKFLDLIEKMLIYDPQKRITPLE--- Dyrk2_Ddis_DYRK2 ----SI------------------------RSGDEDFDNFILDCLKWEPSQRITAEQ--- Prp4_Ddis_PRP4 ----LLP--------------KNVSIPDQDMKKLIQLKDLIEKCTILDPEKRITPFE--- YakA_Ddis_YAK ----IIQNY--GFK-KS--MSPQD--IEKEKQHRIVFTDFINGLLQLDPNERWSPMQ--- 22349_Tthe_YAK ----LKNYMY--NS-QF--RRNED--DTKNNRQFDLFLDLATQLLELNPRKRVKASI--- 10580_Tthe_DyrkP ----R------------------------LKTDDLMFLDFVKSLLQIDRTRRPSAKE--- 22423_Tthe_DyrkP ----R------------------------LRTEDHLFIDFVRQCLQIDFTRRPTAKE--- 5306_Tthe_DYRK2 ---------------------------VI-GCTDDNFIDFIKKCLVWEPSQRLTPRD--- 5356_Tthe_DYRK2 ---------------------------YL-RCPDENFIDFVSKCFTWKNHERMSPAE--- 5655_Tthe_DYRK2 ---------------------------VL-QTESEDFTDFLTKCFVWEPQKRLKPSD--- 15575_Tthe_PRP4 ----LQE--------------NKDGINLENQKKLSQFKDFLDKCLQLDPKNRITPEE--- DYRK1_Spur_DYRK1 ----ILGVEL-GGP-GG--RRAGE--PGHTVSDPHKFKDPILRMLEYDPASRIKPYY--- DYRK2_Spur_DYRK2 ---------------------------ALKGCDDPLFLDFLKRCLEWDPSSRMTPSQ--- DYRK4_Spur_DYRK2 KVKPLLAEDK--AP--S--IEVIE--VED-SEKFLENLEL-DEKNVIDSQEKYAKKE--- HIPKa_Spur_HIPK ----MLHL---------------------------------------------------- HIPKb_Spur_HIPK ----IAGVN-LP---TD--LEGSD--YLAEKADRREFVELLKKMLTIDPDKRITPLE--- PRP4_Spur_PRP4 ----LLGY---------------QRLPEDQQRKVLQLKDVLDRCLMLDPSKRISINE--- CG7028_Dmel_PRP4 ----LIAD---------------QNLPDDQHRKVTQLKDLLENMFALDPAKRISLNQ--- CC1G_13957_Ccin_DYRK2 ----VL------------------------RCNDEEFIDFIAKCLVWDPERRMKPQA--- CC1G_04865_Ccin_PRP4 ----LMPS-------------SSVKLNDEETKMLANFIDLLDKCLMLDPARRITPRE--- CC1G_14245_Ccin_YAK -------------------------------NNRAAFIDFCKGLLDLNPVTRWTPQQ--- AqueK110_Aque_DYRK1 ----VLGGDK-GGP-GG--LRKGD--SGHTPNDYYKFRDLVLQMLDYDPETRIKPLA--- AqueK111_Aque_DYRK1 ----ILGGDK-GGP-GG--LRKGD--SGHTPNDYYKFRDLVLQMLDYDPETRIKPLA--- AqueK112_Aque_DYRK2 ---------------------------AI-KTSDLLFLDFIRRCLVWSASERMKPEE--- AqueK113_Aque_DYRK2 ---------------------------ALKGCDDPQFLDFLRHCLEWDPAIRMTPPQ--- AqueK114_Aque_HIPK ----MNHLPPLA---AG--IDNRE--AILTSVDRMEFISLLSRMLSLDPTQRIRPLS--- AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ----LVGS---------------QSPSEAHLRKIHHFKDFLDKIFILDPTKRLSINQ--- DYRK2_b_Smoe_DYRK2 ---------------------------VV-GCSDKSFVNFLSCCLKWDKEQRMTPQQ--- DYRK2_a_Smoe_DYRK2 ---------------------------VV-GCSDKSFVNFLSCCLKWDKEQRMTPQQ--- DYRKP-2_Smoe_DYRKP ----R------------------------LPMGDQGFLEFVAFLLQINPKNRPSAAE--- DYRKP-1_Smoe_DYRKP ----R------------------------LPMGDQGFLEFVAFLLQINPKNRPSAAE--- PRP4_e_Smoe_PRP4 ----LT---------------------GEDGALMARFKNLLERMLTLDPSKRITPDE--- PRP4_d_Smoe_PRP4 ----LT---------------------GEDGALMARFKNLLERMLTLDPSKRITPDE--- PRP4_b_Smoe_PRP4 ----LIS--------------S-SGGSDEDAKNLLNFKLLLEKIFILDPEKRLTVSQ--- PRP4_a_Smoe_PRP4 ----LIS--------------S-SGGSDEDAKNLLNFKLLLEKIFILDPEKRLTVSQ--- PRP4_c_Smoe_PRP4 ----LT---------------------GEDGALMSRFKNLLERMLTLDPSKRITPDE--- YAK_b_Smoe_YAK ----IISKY--PYK-SS--LSAEE--QEAERQRRLSFLDFLRGLVRFDPKSRWTPHQVCL YAK_a_Smoe_YAK ----IISKY--PYK-SS--LSAEE--QEAERQRRLSFLDFLRGLVRFDPKSRWTPHQ--- YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ----G-----------------------HTSADYEEFEEFLSKILVYDPKRRWTIDE--- GK034_Glam_DYRK2 ----VL------------------------NAP-DDFISFISLFLQWDPQRRCTPEV--- GK033_Glam_DYRK2 ----WLFG-----------ER-----CANLTDEEVLFSDFCRQALIVDPIKRPTAAM--- GK032_Glam_DYRK2 ----ML---------------GWD--S-HPEYCDDLFLDFIETIMRIDPRKRPTAAE--- PRP4_Hsap_PRP4 ------------------ALQHAFIQE--------------------------------- HIPK4_Hsap_HIPK ------------------ALRHPFVSMQQLRSAHETTHYYQL------------------ HIPK3_Hsap_HIPK ------------------TLNHPFVNMKHLLDFPHSNHVKS------------------- HIPK2_Hsap_HIPK ------------------TLNHPFVTMTHLLDFPHSTHVKS------------------- HIPK1_Hsap_HIPK ------------------TLNHQFVTMTHLLDFPHSNHVKS------------------- smi35A_Dmel_DYRK2 ------------------AAHHEFLQPSASSRHRSCR---MS------------------ mnb_Dmel_DYRK1 ------------------ALQHNFFKRTADEATNTSGAGATA------------------ Dyrk3_Dmel_DYRK2 ------------------ALKHPWLRRRLPRPPSSSSG--C------------------- CG17090_Dmel_HIPK ------------------ALNHSFTRLTHLVDYVYCNNVKA------------------- PRP4_Mmus_PRP4 ------------------ALQHAFIQE--------------------------------- HIPK4_Mmus_HIPK ------------------ALRHPFVSMQQLRSAHEATRYYQL------------------ HIPK3_Mmus_HIPK ------------------TLNHPFVNMKHLLDFPHSNHVKS------------------- HIPK2_Mmus_HIPK ------------------TLNHPFVTMTHLLDFPHSAHVKS------------------- HIPK1_Mmus_HIPK ------------------TLNHQFVTMSHLLDFPHSSHVKS------------------- DYRK4_Mmus_DYRK2 ------------------ALKHAWIHEPRKFKPRPKPQI-LR------------------ DYRK3_Mmus_DYRK2 ------------------ALRHPWISKSTPKPLTM-DKVPGK------------------ DYRK2_Mmus_DYRK2 ------------------ALRHPWLRRRLPKPPTGEKTA-VK------------------ DYRK1B_Mmus_DYRK1 ------------------ALQHGFFRRTADEATNTGPAGSSA------------------ DYRK1A_Mmus_DYRK1 ------------------ALQHSFFKKTADEGTNTSNSV--------------------- mbk-2_Cele_DYRK2 ------------------ALKHKWLRRRLPNPPRDGLE-SMG------------------ mbk-1_Cele_DYRK1 ------------------VVRHPFLKQKEERVPSQPPVSHSN------------------ hpk-1_Cele_HIPK ------------------GLESKFVTMTHINGYNFANYVHE------------------- F22D6.5_Cele_PRP4 ------------------ALKHPFFTI--------------------------------- C36B7.2_Cele_DYRK2 ------------------ALDHPFFYSLSACFNQ-QMS---------------------- C36B7.1_Cele_DYRK2 ------------------ILNHPFFHES-------------------------------- DYRK4_Hsap_DYRK2 ------------------ALKHAWIHQSRNLKPQPRPQT-LR------------------ DYRK3_Hsap_DYRK2 ------------------ALRHPWISKSVPRPLTTIDKVSGK------------------ DYRK2_Hsap_DYRK2 ------------------ALRHPWLRRRLPKPPTGEKTS-VK------------------ DYRK1B_Hsap_DYRK1 ------------------ALQHGFFRRTADEATNTGPAGSSA------------------ DYRK1A_Hsap_DYRK1 ------------------ALQHSFFKKTADEGTNTSNSV--------------------- YAK1_Scer_YAK ------------------AMLHPFITKQEFTGEWFPPGSS-------------------- Dyrk1_Ddis_DYRK1 ------------------ALQHSFFLTDETSQPPQQQSQQ-Q------------------ Dyrk2_Ddis_DYRK2 ------------------GLKHDWIIKVIAP----------------------------- Prp4_Ddis_PRP4 ------------------ALNHEFLK---------------------------------- YakA_Ddis_YAK ------------------AKEHPFITGQPYNGPFIPDPSK-KRHFTYSQPKQIPQHSMLN 22349_Tthe_YAK ------------------AMQHPFLNQDENNFYSSLTNQK-I------------------ 10580_Tthe_DyrkP ------------------ALQHPWLTQSH------------------------------- 22423_Tthe_DyrkP ------------------ALSHPWFKLKY------------------------------- 5306_Tthe_DYRK2 ------------------ALLHPWILDGLPEDIRVQHIK-FL------------------ 5356_Tthe_DYRK2 ------------------ALVHDWILEGLPEEIRAQHLQ-QM------------------ 5655_Tthe_DYRK2 ------------------ALMHPWILEGLPPEIRIQHIK-YI------------------ 15575_Tthe_PRP4 ------------------ALEHPFLKLNTT------------------------------ DYRK1_Spur_DYRK1 ------------------ALQHSFFKRTADGSTNTSNST--------------------- DYRK2_Spur_DYRK2 ------------------ALRHSWLRRRLPKPPADGHAN-TT------------------ DYRK4_Spur_DYRK2 ------------------QK---------------------------------------- HIPKa_Spur_HIPK -----------------------FICKSDRT----------------------------- HIPKb_Spur_HIPK ------------------ALNHPFVSLSHLAEYAHCRNTKA------------------- PRP4_Spur_PRP4 ------------------VLRHSFIQE--------------------------------- CG7028_Dmel_PRP4 ------------------ALVHPFIQE--------------------------------- CC1G_13957_Ccin_DYRK2 ------------------AMRHPFVTAGKRKAQQQAAARAT------------------- CC1G_04865_Ccin_PRP4 ------------------ALSHPFIR---------------------------------- CC1G_14245_Ccin_YAK ------------------ARLHPFITGEKFTKPFVPEGLA-P------------------ AqueK110_Aque_DYRK1 ------------------ALKHPFFRKEARLSQSSENGSQYS------------------ AqueK111_Aque_DYRK1 ------------------ALKHPFFRKEARLSQSSENGSQYS------------------ AqueK112_Aque_DYRK2 ------------------ALQHAWIQEGFHSRPRATPRA-LH------------------ AqueK113_Aque_DYRK2 ------------------ALRHPWLRRRLPRAPIISDGQSLS------------------ AqueK114_Aque_HIPK ------------------ALQSPFITMQHLATHTNTQTVWS------------------- AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------ALQHPFIIE--------------------------------- DYRK2_b_Smoe_DYRK2 ------------------LLKHEWITQVLLF-PRESFGL-I------------------- DYRK2_a_Smoe_DYRK2 ------------------LLKHEWITQVLLF-PRESFGL-I------------------- DYRKP-2_Smoe_DYRKP ------------------ALKHPWLSYPY------------------------------- DYRKP-1_Smoe_DYRKP ------------------ALKHPWLSYPY------------------------------- PRP4_e_Smoe_PRP4 ------------------ALKHPFLKS--------------------------------- PRP4_d_Smoe_PRP4 ------------------ALKHPFLKS--------------------------------- PRP4_b_Smoe_PRP4 ------------------ALNHPFIN---------------------------------- PRP4_a_Smoe_PRP4 ------------------ALNHPFIT---------------------------------- PRP4_c_Smoe_PRP4 ------------------ALKHPFLKS--------------------------------- YAK_b_Smoe_YAK LFFIFVYLSNNISHVAFQAAQHPFVTEQPFTGPFEPLPET-P------------------ YAK_a_Smoe_YAK ------------------AAQHPFVTEQPFTGPFEPLPET-P------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------ALNSRFL----------------------------------- GK034_Glam_DYRK2 ------------------AMSHPWIQEGIRQINERN-ARP-S------------------ GK033_Glam_DYRK2 ------------------LLEHPFIKGA-------------------------------- GK032_Glam_DYRK2 ------------------ALEHPWLKH--------------------------------- PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK GNQILNQHQLFQQLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHNQFQQQQQQQQQQQQ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------SLRSYRLSLQVEGKP--------------PTPV--------------------- HIPK3_Hsap_HIPK ------CFHI----MDICKSHLNSCDTNNHN----KTSL--------------------- HIPK2_Hsap_HIPK ------CFQN----MEICKRRVNMYDTVNQS----KTPF--------------------- HIPK1_Hsap_HIPK ------CFQN----MEICKRRVHMYDTVSQI----KSPF--------------------- smi35A_Dmel_DYRK2 ------S-----------------------------S----------------------- mnb_Dmel_DYRK1 -------------------------------------NA--------------------- Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------SVQM----MEVCRRGD--FHTVQ-P----ASTL--------------------- PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------SLRGCRLSLQVDGKP--------------PPPV--------------------- HIPK3_Mmus_HIPK ------CFHI----MDICKSPS-SCETNNHS----KMSL--------------------- HIPK2_Mmus_HIPK ------CFQN----MEICKRRVNMYDTVNQS----KTPF--------------------- HIPK1_Mmus_HIPK ------CFQN----MEICKRRVHMYDTVSQI----KSPF--------------------- DYRK4_Mmus_DYRK2 ------K------------------------------P---------------------- DYRK3_Mmus_DYRK2 ------RV---------------------------VNP---------------------- DYRK2_Mmus_DYRK2 ------RV---------------------------T------------------------ DYRK1B_Mmus_DYRK1 ------S----------------------------TSPA--------------------- DYRK1A_Mmus_DYRK1 ------S----------------------------TSPA--------------------- mbk-2_Cele_DYRK2 ------GL---------------------------A------------------------ mbk-1_Cele_DYRK1 ------LQ--------------------QQQQLYIQQPSSQ-MSQVM---E--------- hpk-1_Cele_HIPK ------AHKR----MEICRKPGPAMATPY-R----AANV--------------------- F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------K------------------------------S---------------------- DYRK3_Hsap_DYRK2 ------RV---------------------------VNP---------------------- DYRK2_Hsap_DYRK2 ------RI---------------------------T------------------------ DYRK1B_Hsap_DYRK1 ------S----------------------------TSPA--------------------- DYRK1A_Hsap_DYRK1 ------S----------------------------TSPA--------------------- YAK1_Scer_YAK -------------------------------L---PGPSEK------------------- Dyrk1_Ddis_DYRK1 ------SQ--------------------QQSQ---QQSQQQ--SQQQ---S-------Q- Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK SSSQQHIQI-----------QPLQLFSTPYTS---TNN---------------------- 22349_Tthe_YAK ------ENT-----------KE----FSLDQS---TSDERH--NDIK---Q--------- 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------KD---------------------------KS----------------------- 5356_Tthe_DYRK2 ------QQ---------------------------TSPE--------------------- 5655_Tthe_DYRK2 ------QS---------------------------QV-E--------------------- 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------S----------------------------ASPA--------------------- DYRK2_Spur_DYRK2 ------SA---------------------------K------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------CSLNYHT----HESL--------------------- HIPKb_Spur_HIPK ------SVRA----MEVCKRGTQLFENTNQS----KYAF--------------------- PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------P----------------------------SSSS--------------------- CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------SQ--------------------PSSS---SSPNTP--DPK---RPYGGLVPSQP AqueK110_Aque_DYRK1 ------S----------------------------TTPT--------------------- AqueK111_Aque_DYRK1 ------S----------------------------TTPT--------------------- AqueK112_Aque_DYRK2 ------I-----------------------------SP---------------------- AqueK113_Aque_DYRK2 ------QG---------------------------IPPH--------------------- AqueK114_Aque_HIPK ------WIQA----MAVCHQPRLS-----------TTPL--------------------- AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------RT--------------------PV-----GHPMTVEHNPGAGHWFGAGLSPQ-- YAK_a_Smoe_YAK ------RT--------------------PV-----GHPMTVEH----------------- YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------S----------------------------TAVR--------------------- GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ---------------------------------------V---AA-E------------- HIPK3_Hsap_HIPK ---------------------------------------LRPVASSSTATLTAN------ HIPK2_Hsap_HIPK ---------------------------------------ITHVAPSTSTNLTMT------ HIPK1_Hsap_HIPK ---------------------------------------TTHVAPNTSTNLTMS------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ---------------------------------------VTNFVPSSTENMTFT------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ---------------------------------------I---ASAE------------- HIPK3_Mmus_HIPK ---------------------------------------LRPVASNGTAALAAN------ HIPK2_Mmus_HIPK ---------------------------------------ITHVAPSTSTNLTMT------ HIPK1_Mmus_HIPK ---------------------------------------TTHVAPNTSTNLTMS------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ---------------------------------------ATPIT---------------- F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 -QRRQSNT---------------------------------------------------- Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK -------------------------------------------TPNLSSSNSGSSLNNLK 22349_Tthe_YAK -----QQQQSNQNTDFNLFKVSDQNAAIVKKAIQNQKENQEKLKP---NQL--------- 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ---------------------------------------LKVKASIGNA----------- HIPKb_Spur_HIPK ---------------------------------------LTHLASSTCTILAIK------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK KGTRA------------------------------------------------------- AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ---------------------------------------S-------------------- AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ---------FT-KIGTLRS-QAL------TT----------------------------- HIPK2_Hsap_HIPK ---------FNNQLTTVHN-QAP------SS----------------------------- HIPK1_Hsap_HIPK ---------FSNQLNTVHN-QASVLASSSTA----------------------------- smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ---------INNQLTSQV------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ---------FT-KVGTLRS-QAL------TT----------------------------- HIPK2_Mmus_HIPK ---------FNNQLTTVHN-QAP------TT----------------------------- HIPK1_Mmus_HIPK ---------FSNQLNTVHN-QASVLASSSTA----------------------------- DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK KLNLPPFKQQ--------QQQQFSTS----QNSDSFNFPNESFSPRGIYIPSSAS----- 22349_Tthe_YAK --TSDP------------------------------------------------QQQQIN 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------ELP--------------TI----------------------------- PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK -------------S---------------------------AHSVVHHGI---------- HIPK2_Hsap_HIPK -------------TSATISLANPEVSILNYPSTLYQPSAASMAAVAQRSM---------- HIPK1_Hsap_HIPK -------------AAATLSLANSDVSLLNYQSALYPSSAAPVPGVAQQGV---------- smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------QRLVRDGRPLAYEGLYQI PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK -------------S---------------------------AHSVVHHGI---------- HIPK2_Mmus_HIPK -------------SSATLSLANPEVSILNYQSALYQPSAASMAAVAPRSM---------- HIPK1_Mmus_HIPK -------------AAATLSLANSDVSLLNYQSALYPSSAAPVPGVAQQGV---------- DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK -------------------------------------------NIQQQQQ---------- 22349_Tthe_YAK NLLSEIGQEQNLQS---------------------------QYYL--NQY---------- 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK -------------STEILKLENHELHLFSYYSAVYQPPQI-AQRVSQNTN---------- PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ----------PLQAGTAQFG-CGDAF--------------QQTL---IICPPAIQGIPAT HIPK2_Hsap_HIPK ----------PLQTGTAQICARPDPF--------------QQAL---IVCPPGFQGLQAS HIPK1_Hsap_HIPK ----------SLQPGTTQICTQTDPF--------------QQTF---IVCPPAFQTGLQA smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK YNGRSVARQYP--------QTRTDSF--------------QHQLVSNILCPPSYQTM-PS PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ----------PLQAGTAQFG-CGDAF--------------HQTL---IICPPAIQGIPAA HIPK2_Mmus_HIPK ----------PLQTGTAQICARPDPF--------------QQAL---IVCPPGFQGLQAS HIPK1_Mmus_HIPK ----------SLQPGTTQICTQTDPF--------------QQTF---IVCPPAFQTGLQA DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK -------------------------------------------------------PV-EK F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ----------PININNNQN--G------------VGSQVSQL----ALGQSPSLFGTPT- 22349_Tthe_YAK ----------PLQQQQGQY--QNDPYNFHTQQPGI-------------------QQIPF- 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ----------QPQPATTQY-PRPDPF--------------QQVM---IMYSPGFEGVLGL PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ---------------------YQDAATYNHH----------------------------- AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ----------------------------------D--------G------TPYYCLA--- HIPK3_Hsap_HIPK HGKPTSYSIRVDN----------------------------------------------- HIPK2_Hsap_HIPK PSKHAGYSVRMEN----------------------------------------------- HIPK1_Hsap_HIPK TTKHSGFPVRMDN----------------------------------------------- smi35A_Dmel_DYRK2 -------------------------------------------S---------------- mnb_Dmel_DYRK1 -------------------------------GAGG--------S------GSSGAG---- Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK PTKH-----V-------------------------------------------------- PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ----------------------------------D--------G------PPYYRLA--- HIPK3_Mmus_HIPK HGKPTSYSIRVDN----------------------------------------------- HIPK2_Mmus_HIPK PSKHAGYSVRMEN----------------------------------------------- HIPK1_Mmus_HIPK TTKHSGFPVRMDN----------------------------------------------- DYRK4_Mmus_DYRK2 -------------------------------------------G---------------- DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 -------------------------------PL-D--------T------CPSSST---- DYRK1A_Mmus_DYRK1 -------------------------------ME-Q--------S------QSSGTT---- mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 -------------------------------------------S---------------- hpk-1_Cele_HIPK PPAP-----KLQQPMIAVLPQLNQIAATNIPPV-P--------T------QPDLTNLMHH F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 -------------------------------------------N---------------- DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 -------------------------------PL-D--------T------CPSSST---- DYRK1A_Hsap_DYRK1 -------------------------------ME-Q--------S------QSSGTT---- YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------DNNFSNNNP--------------- Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK NI-----------------------------------------YPPYSSMY--------- 22349_Tthe_YAK NQSFTQQPQIYNNYLNQNMYQYPYQFQQQQYAQQMSQMLPQQQQP--------------- 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 -------------------------------FE-T--------A-------SE-K----- 5356_Tthe_DYRK2 -------------------------------ID-M---------------TKSQ------ 5655_Tthe_DYRK2 -------------------------------ID-R--------L------TQEQQ----- 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 -------------------------------MD-Q--------A------GSPPAE---- DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK PSSHLG------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 -------------------------------LS-S--------H------RSKHIT---- CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 -------------------------------QT-I--------G------LTSSSS---- AqueK111_Aque_DYRK1 -------------------------------QT-I--------G------LTSSSS---- AqueK112_Aque_DYRK2 -------------------------------------------S---------------- AqueK113_Aque_DYRK2 -------------------------------LP----------S-------A--A----- AqueK114_Aque_HIPK --------------------------------I-N--------T------HPSLQLL--- AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 -------------------------------AV-D--------A------R--------- GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK -EEKE--------------------------------------------A-AG-M----- HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ---------------------------------------------------SS-S----- mnb_Dmel_DYRK1 --GSS--------------------------------------------G-GG-V----- Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK -EEEE--------------------------------------------T-AG-L----- HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ---------------------------------------------------AS-I----- DYRK3_Mmus_DYRK2 ------------------------------------------------------T----- DYRK2_Mmus_DYRK2 ---------------------------------------------------ES-T----- DYRK1B_Mmus_DYRK1 --ASS--------------------------------------------I-SS-S----- DYRK1A_Mmus_DYRK1 --SST--------------------------------------------S-SS-S----- mbk-2_Cele_DYRK2 ---------------------------------------------------DH------- mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK YS--Q--------------------------------------------M-AAAT----- F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ---------------------------------------------------SF-F----- DYRK3_Hsap_DYRK2 ------------------------------------------------------A----- DYRK2_Hsap_DYRK2 ---------------------------------------------------ES-T----- DYRK1B_Hsap_DYRK1 --ASS--------------------------------------------I-SS-S----- DYRK1A_Hsap_DYRK1 --SST--------------------------------------------S-SS-S----- YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ----------------------------------------NNSPVATPNSLSF-YG---- 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 --EFH--------------------------------------------K--Q-S----- 5356_Tthe_DYRK2 ----------------------------------------------------S-S----- 5655_Tthe_DYRK2 --QYD--------------------------------------------K--Q------- 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 --HSS--------------------------------------------G-SS-S----- DYRK2_Spur_DYRK2 ---------------------------------------------------NK-R----- DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 --ETP--------------------------------------------K-KS-M----- CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 --QPIDSFVISQEIVAMETNHTHPPPGLGELIPGRHIHLQNLSPPETHDA-SL-YGGNNG AqueK111_Aque_DYRK1 --QPIDSFVISQEIVAMETNHTHPPPGLGELIPGRHIHLQNLSPPETHDT-SL-YGGNNG AqueK112_Aque_DYRK2 ---------------------------------------------------SS-A----- AqueK113_Aque_DYRK2 --AVH--------------------------------------------L-SS-S----- AqueK114_Aque_HIPK -G--H--------------------------------------------T-GLTG----- AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ---GSVA-------------GS----SPF-----FREEK--------------------- HIPK3_Hsap_HIPK ----------------------------------------------TVPLVTQ------- HIPK2_Hsap_HIPK ----------------------------------------------AVPIVTQ------- HIPK1_Hsap_HIPK ----------------------------------------------AVPIVPQ------- smi35A_Dmel_DYRK2 ---GLNSV-----SQKSS------------------CYS--------------------- mnb_Dmel_DYRK1 ---GGGL-------------GA----SNS-----SSGAVSSSSAAA-------------- Dyrk3_Dmel_DYRK2 ---GGVS----------------------------------------------------- CG17090_Dmel_HIPK -------------------------------------------------VVGS------- PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ---GGVT-------------GS----GSF-----FREDK--------------------- HIPK3_Mmus_HIPK ----------------------------------------------TVPLVTQ------- HIPK2_Mmus_HIPK ----------------------------------------------AVPIVTQ------- HIPK1_Mmus_HIPK ----------------------------------------------AVPIVPQ------- DYRK4_Mmus_DYRK2 ---SSEIS-----TEK-------------------------------------------- DYRK3_Mmus_DYRK2 ---NAFQG---------------------------------------------------- DYRK2_Mmus_DYRK2 ---GAITS---------------------------------------------------- DYRK1B_Mmus_DYRK1 ---GGSS-------------GS----SND-----NRAYR--------------------- DYRK1A_Mmus_DYRK1 ---GGSS-------------GT----SNS-----GRARS------D-------------- mbk-2_Cele_DYRK2 -----EKK---------------------------------------------------- mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ---GSAA-------------TA----AQF-----FYQPL------PPAPLFQYAQLHHPF F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ---PSETR-----KDK-------------------------------------------- DYRK3_Hsap_DYRK2 ---SAFQG---------------------------------------------------- DYRK2_Hsap_DYRK2 ---GAITS---------------------------------------------------- DYRK1B_Hsap_DYRK1 ---GGSS-------------GS----SSD-----NRTYR--------------------- DYRK1A_Hsap_DYRK1 ---GGSS-------------GT----SNS-----GRARS------D-------------- YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ----SSW-------------GSDSSSI--------------------------------- 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ---CLQAQ-----YNADAQ----------------------------------------- 5356_Tthe_DYRK2 ---NKANTIEDQPQNNENTSG---------VGQGRNSFK--------------------- 5655_Tthe_DYRK2 -------------NNNSMT----------------------------------------- 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ---GGAT-------------GG----SNNGSGTGGRAQS------D-------------- DYRK2_Spur_DYRK2 ---HGSSA---------------------------------------------------- DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ---IG------------------------------------------------------- CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 RGVVGSS-------------GT----L--GSGT--------------------------- AqueK111_Aque_DYRK1 RGVVGSS-------------GT----L--GSGT--------------------------- AqueK112_Aque_DYRK2 ---GTPSS-----SSH-------------------------------------------- AqueK113_Aque_DYRK2 ---GAATN---------------------------------------------------- AqueK114_Aque_HIPK ---GGVL-------------PT----S-C-----CRQSL------QT------------- AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ----------------APG----------------MQ-----------------RAI--- HIPK3_Hsap_HIPK ----------------APA----------------VQ-----------------PL---- HIPK2_Hsap_HIPK ----------------APG----------------AQ-----------------PL---- HIPK1_Hsap_HIPK ----------------APA----------------AQ-----------------PL---- smi35A_Dmel_DYRK2 -------------------FSEI------SPGTNGPVVASITSTTAVHN----------- mnb_Dmel_DYRK1 -----------------PT-------------------------------------AATA Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ----------------ATM----------------QP-----------------PL---- PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ----------------APG----------------MQ-----------------RAI--- HIPK3_Mmus_HIPK ----------------APA----------------VQ-----------------PL---- HIPK2_Mmus_HIPK ----------------APG----------------AQ-----------------PL---- HIPK1_Mmus_HIPK ----------------APA----------------AQ-----------------PL---- DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 -------------------YSNR---YCGG-----PG-------------------P--P DYRK1A_Mmus_DYRK1 -----------------PTHQHR---HSGG--HFAAA-------------------V--Q mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK AARPPHFLSLATPSHMVPQ----------------FV-----------------PV---- F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 -------------------YSNR---YCGG-----PG-------------------P--P DYRK1A_Hsap_DYRK1 -----------------PTHQHR---HSGG--HFTAA-------------------V--Q YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 -----------------------------SA----------------------------- 5356_Tthe_DYRK2 -------------------KAEMNN---SSS--FGPSVVSVNTGLQERNKNIINSQS--- 5655_Tthe_DYRK2 -----------------------------SS----------------------------- 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 -----------------PTHQNSTSNHALGHQHPGSS-------------------A--G DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ----------------------FSN---SG--SFGSA----------------------- AqueK111_Aque_DYRK1 ----------------------FSN---SG--SFGSA----------------------- AqueK112_Aque_DYRK2 ----------------------------------------------Y------------- AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK --------------DQLDDLS--------------------------------------- HIPK3_Hsap_HIPK --------------------QIR---PGVL------------------------------ HIPK2_Hsap_HIPK --------------------QIQ---PGLL------------------------------ HIPK1_Hsap_HIPK --------------------QIQ---SGVL------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 AATAAGSSGSGSSVG----GGSSAAQQQQAMPLPLPLPLPLP------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK --------------------QVP---PQQYVNVP------VPVSMVEPTSGQRMLLTNRV PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK --------------DQLDDLS--------------------------------------- HIPK3_Mmus_HIPK --------------------QIR---PGVL------------------------------ HIPK2_Mmus_HIPK --------------------QIQ---PGLL------------------------------ HIPK1_Mmus_HIPK --------------------QIQ---SGVL------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 I------------TD----CEMNSPQVLP--------SQPL------------------- DYRK1A_Mmus_DYRK1 A------------MD----CETHSPQVRQ--------QFPAP------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK --------------------PIMD--PSM------------------------------- F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 I------------TD----CEMNSPQVPP--------SQPL------------------- DYRK1A_Hsap_DYRK1 A------------MD----CETHSPQVRQ--------QFPAP------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 A------------MD----YESMSSH------------SSLT------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 --------------------------------------APTP------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 -------------MD----I--GQPQ------------QP-------------------- AqueK111_Aque_DYRK1 -------------MD----I--GQPQ------------QP-------------------- AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK --S----------------------------------------------QT--WSGRT-- HIPK2_Hsap_HIPK --AQ---------------------------------------------QA--WPSGT-- HIPK1_Hsap_HIPK --TQGSCTPLMVATLHPQVATITPQYAVPFTLSCAAGRPALVEQTAAVLQA--WPGGT-- smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 --------------------------------------------------PLAGPGGASD Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK QAS---------------------------------------------GVA--WPQTG-- PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK --SQ---------------------------------------------QT--WSGRT-- HIPK2_Mmus_HIPK --AQ---------------------------------------------QA--WPGGA-- HIPK1_Mmus_HIPK --TQGSCTPLMVATLHPQVATITPQYAVPFTLSCAAGRPALVEQTAAVLQA--WPGGT-- DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 -------------------------------------------------RP--WAGG--- DYRK1A_Mmus_DYRK1 -------------------------------------------------LG--WSGT--- mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK --L---------------------------------------------QGQ--WPPGA-- F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 -------------------------------------------------RP--WAGG--- DYRK1A_Hsap_DYRK1 -------------------------------------------------LG--WSGT--- YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 -------------------------------------------------SGM--SSG--- DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ----------------------------------LQEAGHGL------------------ HIPK3_Hsap_HIPK ------------------------------QQMLV---------------P-AWQQV-TP HIPK2_Hsap_HIPK ------------------------------QQILL---------------PPAWQQL-TG HIPK1_Hsap_HIPK ------------------------------QQILL---------------PSTWQQL-PG smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 GQCHGLLMHSVAANAMNNFSALSLQSNAHP------------------PPSLAN------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK -----------------------------RQMALV----------------PSWPQQAPA PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ----------------------------------LQEARRGL------------------ HIPK3_Mmus_HIPK ------------------------------QQMLI---------------P-AWQQV-TP HIPK2_Mmus_HIPK ------------------------------QQILL---------------PPAWQQL-TG HIPK1_Mmus_HIPK ------------------------------QQILL---------------PSAWQQL-PG DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ----------------------------DV------------------PH---------- DYRK1A_Mmus_DYRK1 ----------------------------EA------------------PTQVTVE----- mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK -----------------------------AQQFAV-----LANDIMRVPAPQGI------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ----------------------------DV------------------PH---------- DYRK1A_Hsap_DYRK1 ----------------------------EA------------------PTQVTVE----- YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ----------------------------DV------------------A----------- DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ---------------------------------------------------LTAR----- CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 -------------------------------------------------VAMTME----- AqueK111_Aque_DYRK1 -------------------------------------------------VAMTME----- AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ----------------------------------------GLYQTAVIP----------- AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK LAP--------------------------------------------------------- HIPK2_Hsap_HIPK VATHTSV----------------------------------------------------- HIPK1_Hsap_HIPK VALHNSV----------------------------------------------------- smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK HSLI--VDSTPLFNVEEIYPKHHLNLPRNDLKKESPAHHIAKGNSYRVPRHEKKEHQQLS PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK MAP--------------------------------------------------------- HIPK2_Mmus_HIPK VATHTSV----------------------------------------------------- HIPK1_Mmus_HIPK VALHNSV----------------------------------------------------- DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK --------------------------------------------------------AT-- HIPK2_Hsap_HIPK --------------------------------------------------------QH-- HIPK1_Hsap_HIPK --------------------------------------------------------QP-- smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 -SHHSTN--------------------------------------------------SLG Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK PVKKRVKESSPPHQQRYQRAAHVSPQYHAHHNCNYGNGSGYSASAGSVVASSAASSSN-- PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK --------------------------------------------------------AA-- HIPK2_Mmus_HIPK --------------------------------------------------------QH-- HIPK1_Mmus_HIPK --------------------------------------------------------QP-- DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 -T-HPVQ--------------------------------------------------E-- mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 -T-HPVQ--------------------------------------------------E-- YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ---HQI------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 -T---------------------------------------------------------- CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 -A---------------------------------------------------------- AqueK111_Aque_DYRK1 -A---------------------------------------------------------- AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------W----------------------------------------- HIPK3_Hsap_HIPK --TTLTSESVAGSHRLGDW----------------------------------------- HIPK2_Hsap_HIPK --ATVIPETMAGTQQLADW----------------------------------------- HIPK1_Hsap_HIPK --TAMIPEAMGSGQQLADW----------------------------------------- smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 SLNHISPG----------S----------------------------------------- Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK --I-V-----NGSSSSSH------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------W----------------------------------------- HIPK3_Mmus_HIPK --ATLTSEGMAGSQRLGDW----------------------------------------- HIPK2_Mmus_HIPK --AAVIPETMAGTQQLADW----------------------------------------- HIPK1_Mmus_HIPK --AAVIPEAMGSSQQLADW----------------------------------------- DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 TTFHVAPQ----------Q----------------------------------------- mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 TTFHVAPQ----------Q----------------------------------------- YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------SLNPSTPTQKQMFQQQQYSNNNNNNNNNNNNNSNNNNGNNTN 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ----FASS----------S----------------------------------------- DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------S----------------------------------------- AqueK111_Aque_DYRK1 ------------------S----------------------------------------- AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK NINSNNNNNNVNRRNRSKSDIPSDSFSSSEGMDPQFNLYQQQQQQQQQQQQQQQQQQQQQ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK QQQQQQQQQQQQQLQYQQQFQTLQDLNIEGEKPPIYPNSPHRKRSHSGYLDQYANGYNSQ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ----------------------------------G------------------------- HIPK3_Hsap_HIPK ----------------------------------G------------------------- HIPK2_Hsap_HIPK ----------------------------------R------------------------- HIPK1_Hsap_HIPK ----------------------------------R------------------------- smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ---------------TGCHNNNSN---------SS------------------------- Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ----------------------------------S------------------------- HIPK3_Mmus_HIPK ----------------------------------G------------------------- HIPK2_Mmus_HIPK ----------------------------------R------------------------- HIPK1_Mmus_HIPK ----------------------------------R------------------------- DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ---------------NALHHHHGN---------SS------------------------- mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ---------------NALHHHHGN---------SS------------------------- YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK QTNNTQQQQQQQQQQQQQQQQQQQQQQHPSFFSTRMHLDHFNGGSRYRSQSYGDQQFQQQ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ---------------SSAHGHSSSHTYPHPHSHSR------------------------- DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ---------------SSLHQVTGSH---RPHS---------------------------- AqueK111_Aque_DYRK1 ---------------SSLHQVTGSH---RPHS---------------------------- AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK -------ETCTNAV-------------------SDMMVPLKAA-------ITGHHVPDSG HIPK3_Hsap_HIPK -------KMISCSN-------------------HYNSVMPQP--------LLTNQITLSA HIPK2_Hsap_HIPK -------NTHAHGS-------------------HYNPIMQQPA-------LLTGHVTLPA HIPK1_Hsap_HIPK -------QAHSHGN-------------------QYSTIMQQPS-------LLTNHVTLAT smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 -------NNNTRHSRLYGSNMVNMVGHHNSGSSN-------------------------- Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ----------------------------------------------------HHHVPVAH PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK -------DTRADMV-------------------SDMLVPLKVA-------STSHRVPDSG HIPK3_Mmus_HIPK -------KMIPHSN-------------------HYNSVMPPP--------LLTNQITLSA HIPK2_Mmus_HIPK -------NTHAHGS-------------------HYNPIMQQPA-------LLTGHVTLPA HIPK1_Mmus_HIPK -------NAHSHGN-------------------QYSTIMQQPS-------LLTNHVTLAT DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 -------HHHHHHHHH----------HHHH-GQQ-------------------------- mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK -----------------------------------------------------NQMFAST F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 -------HHHHHHHHH----------HHHH-GQQ-------------------------- YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ----INN----------------------------------------------------- Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK QYKQQQKNLHHQQQ-------------------QQQRFMQVGS-------PPTSHLSPPI 22349_Tthe_YAK ----VQQSTFPYQQ-------------------PYNQVQQQQQ-------MSTDQLANLF 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 -------KH-----------------HHHH-SS--------------------------- DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK -----------------------------------------PISKNEIEAL--------- HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK --------------------------------------------------L--------- AqueK110_Aque_DYRK1 -------------------------------GRK-------------------------- AqueK111_Aque_DYRK1 -------------------------------GRK-------------------------- AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ---------------------------------------HNGA-------HLVCHVAPST AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK --------------------------------------------------VCAHVICLFL YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK P-------EPI------------------------------------------------L HIPK3_Hsap_HIPK P-------QPV------------------------------------------------S HIPK2_Hsap_HIPK A-------QPL------------------------------------------------N HIPK1_Hsap_HIPK A-------QPL------------------------------------------------N smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ---------------------------NHNSISYPHAMECDPP----------------- Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK A-------QPYSSSSGHHIVSNCNANGGAGGAVVYQQPPAHAHQQHGQQPHPQSSQHPQ- PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK P-------EPI------------------------------------------------L HIPK3_Mmus_HIPK P-------QPI------------------------------------------------S HIPK2_Mmus_HIPK A-------QPL------------------------------------------------N HIPK1_Mmus_HIPK A-------QPL------------------------------------------------N DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ---------------------------ALGNRTR--------P----------------- mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK P---------------------------------------------------------QT F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ---------------------------ALGNRTR--------P----------------- YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK PQSPLMMSQPL------------------------------------------------- 22349_Tthe_YAK S-------QQL------------------------------------------------N 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ----------------------------HG-HSL--------P----------------- DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------P----------------- CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK -----------------------------------------------------------A AqueK110_Aque_DYRK1 ---------------------------GEG-GER--------K----------------- AqueK111_Aque_DYRK1 ---------------------------GEG-GER--------K----------------- AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK F-------GYL------------------------------------------------P AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK L-------NAL------------------------------------------------V YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK -------------------------------AFY-------------S------------ HIPK3_Hsap_HIPK -------------------------------V-GI--AH--VVWPQPA------------ HIPK2_Hsap_HIPK -------------------------------V-GV--AH--VMRQQPT------------ HIPK1_Hsap_HIPK -------------------------------V-GV--AH--VVRQQQS------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK -------------------------------AFY-------------G------------ HIPK3_Mmus_HIPK -------------------------------V-GI--AH--VVWPQPA------------ HIPK2_Mmus_HIPK -------------------------------V-GV--AH--VMRQQPT------------ HIPK1_Mmus_HIPK -------------------------------V-GV--AH--VVRQQQS------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK -------------------------------F-SLPQFL--S------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK -------------------------------L-QT--SN--QFQNQKQ------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK QHQAYTAQQASQAANTFRNPYINPPAQQQQSQ--Q--QHQQQPPSQPPVAQTTYTNPPAD AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK -------------------------------V-SH--SH--LIQTHQR------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK -------------------------------L-QV--SH--IPVPLP------------- YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ---SRLA----------------------------------------------------- HIPK3_Hsap_HIPK ---TTKKNK--------------------------------------------------- HIPK2_Hsap_HIPK ---STTSSR--------------------------------------------------- HIPK1_Hsap_HIPK ---SSLPSK--------------------------------------------------- smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ---SRLT----------------------------------------------------- HIPK3_Mmus_HIPK ---TTKKNK--------------------------------------------------- HIPK2_Mmus_HIPK ---STTSSR--------------------------------------------------- HIPK1_Mmus_HIPK ---SSLPSK--------------------------------------------------- DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------PSVG--SVYVEDNGMYR------------------- hpk-1_Cele_HIPK ---SSIPSA--------------------------------------------------- F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK --H---D----DAKG-------QQSEYG--SAN----DSSNN------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ---HQ------------------------------------------------------- 22349_Tthe_YAK ---SF------------------------------------------------------- 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK PYH---P----QSQQQQSQSQHLSGQYGSGAAQ--------------------------- AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ---ETHPVL--------------------------------------------------- AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK --QYSSPQYYGGQFS-------FASSYG--SC-----GSYGSCDGYGMGGSYAGSYTEAS YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK --AGH------------------------------------------------------- Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK -------------------TYIPQQQQQQQQQQQQSQPTPFTPQMISQEPISPALMGDAS 22349_Tthe_YAK -------------------RNQKQSKKCLSQQDSLDYQKEFYDDYPNQFQNNQIQDKNMW 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK --TAHRALAHANSANQLGSGAS-------------------------------------- AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK NMY--------------------------------------------------------- YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ----------------------------------------N------------------- Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK SIWNPSPTEELLFTIDLPNQQNTPHLT--------------------------------- 22349_Tthe_YAK STNQFTNIQNQGNFYKNSNYNYQKTGT--------------------------------- 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK -------------------------GSQYPSHSSATNLSSSHLNPNVSSGSYYPNSRARA AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK -----------------------------------------------YVY---------- Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK NTINQMDT-IPPALARLQHMNQDIIGGRNALTPVLNRDDAMKEWERRQSG---------- AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK -----CNYPTPPQIGYE-------------------------QWRRLHPPIPAGYGQLGR YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 -------------------QAPGSSANPISVTSSFDEGDAMEVDAGRRRFSAHQQNYHNP hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK --------------------------NP-------------------------------- Dyrk1_Ddis_DYRK1 ------------------YNSPSSK-SP-------------------------------- Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK -PSNSSTNLLGKSASSPLKNSSGGA-IP-------------------------------- 22349_Tthe_YAK -NQGFQQGISNIENIQDQQVPPA------------------------------------- 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK --------------------------KP-------------------------------- AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK SPSSSVFTPMSLGGSPSQFTPPSSQ-FP-------------------------------- YAK_a_Smoe_YAK --------------------------NP-------------------------------- YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 NYQYSQPQ-------------------QQQ------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK -----------------SS----------------------------------------- Dyrk1_Ddis_DYRK1 -----HQQ-------------------LQQ------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK -----------------------------NIKDIFDNVDDNFPKQQLNQQPQQLIHLQNY 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK -----------------PAAQPYPQLEYL------------------------------- AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK -----SPGSSPGRCGPPSP----------------------------------------- YAK_a_Smoe_YAK -------G---------------------------------------------------- YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK -------------------------------------------------------TTAFN F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK QQGNQQQMPQGFLLNSQYIQNFYNPQQQLGMNIGNLQPNNNLLGNQFQVQDQPQQQN--- 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK -------------------------------------------------------TT--- AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ---------------------------GR------------------------------- HIPK3_Hsap_HIPK -------------------------QCQN-RGI-LVKLMEWEPGREEINAFSWSNSLQNT HIPK2_Hsap_HIPK -------------------------KSKQHQSSVRNVSTCEVSSSQAISSPQRSKRVKEN HIPK1_Hsap_HIPK -------------------------KNKQS-APVSSKSSLDVLPSQVY------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ---------------------------GR------------------------------- HIPK3_Mmus_HIPK -------------------------LCQN-RGI-LVRLMEWEPGREEINAFRWSNSLQNT HIPK2_Mmus_HIPK -------------------------KSKQHQSSVRNVSTCEVTSSQAISSPQRSKRVKEN HIPK1_Mmus_HIPK -------------------------KNKQS-APVSSKSSLEVLPSQVY------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK GNAPNIPFPEENSSWALGTAAQQQQQQ--------------------------------- F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK --GQWILEPTT------RLQQQQQQQ---------------------------------- AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK NIPHSAFISPKIINGKDVEEVSCIETQDNQNSEGEARNCCE-------TSIRQDSDSSVS HIPK2_Hsap_HIPK TPPRCAMVH--------------------------SSPACSTSVTCGWG---DVASSTTR HIPK1_Hsap_HIPK -----SLVG--------------------------SSPLRTTSS---------YNSLVPV smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK NIPHSAFISPKIISGKEVEEVSCVDTQDNHTSEGEAGTCRE-------ASV--RQDSSVS HIPK2_Mmus_HIPK TPPRCAMVH--------------------------SSPACSTSVTCGWG---DVASSTTR HIPK1_Mmus_HIPK -----SLVG--------------------------SSPLRTTSS---------YNSLVPV DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK -------------------------------------------------AQRAQSMINGN F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK -------------------------------------------------QQQQ------- AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK DKQR-------------------------------------------------------- HIPK2_Hsap_HIPK ERQR-------------------------------------------------------- HIPK1_Hsap_HIPK QDQH-------------------------------------------------------- smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK HVKQ-------------------------------------------------------- PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK DKQR-------------------------------------------------------- HIPK2_Mmus_HIPK ERQR-------------------------------------------------------- HIPK1_Mmus_HIPK QDQH-------------------------------------------------------- DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ---------------------------------------------------QQQY----- hpk-1_Cele_HIPK VKVK-------------------------------------------------------- F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ---------------------------------------------------Q--QQ---- Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ---QQYQLFQQQFNQQNYGFNQFNNQQNMRQNYQLFNQNNLQQNLFLQNQQY--YQ---- 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 -RSS-------------------------------------------------------- CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------QQQAEI AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ----------------------------------QQTQRTQLEQQQKQAQLQQQLQQQQM hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK --------------------ATGGADSVDIG----------------------------- Dyrk1_Ddis_DYRK1 ---------------------------------QQ---QQ------------QQQQQQQQ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK -----------------------------------------------------QQQQQLQ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK VAASGLANWASGPHTRYPAQPSKLQHSYQPH----------------------------- AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK --------------------ARYGKAAS-VSHYKQ---RR-------------------- YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ----------------------------------------------------QTIIIADS HIPK2_Hsap_HIPK ----------------------------------------------------QTIVIPDT HIPK1_Hsap_HIPK ----------------------------------------------------QPIIIPDT smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 -------------------------------------------------------Q---- Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ----------------------------------------------------PTITIHDT PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ----------------------------------------------------QTIIIADS HIPK2_Mmus_HIPK ----------------------------------------------------QTIVIPDT HIPK1_Mmus_HIPK ----------------------------------------------------QPIIIPDT DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 -------------------------------------------------------K---- DYRK1A_Mmus_DYRK1 -------------------------------------------------------R---- mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 QQQQQQQQQRQHMPQAQSSSQQHLQSRARPRQQDQNEWRNQ------------------- hpk-1_Cele_HIPK ----------------------------------------------------PLAAQPKK F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 -------------------------------------------------------K---- DYRK1A_Hsap_DYRK1 -------------------------------------------------------R---- YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 QQQQQQQQQQTYSPTT------------------------QQSNHKLVDQMKKASM--KD Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ----------------------------------------------------------PT 22349_Tthe_YAK QQQQPLNQQNSQFPQQ------------------------TNQQQTYYN----------- 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 -------------------------------------------------------S---- DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ----------------------------------------------------HTSG---- CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ---------GLYAPMN------------------------Q------------------- YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK PS---------------------------------------------------------- HIPK2_Hsap_HIPK PS---------------------------------------------------------- HIPK1_Hsap_HIPK PS---------------------------------------------------------- smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK PS---------------------------------------------------------- PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK PS---------------------------------------------------------- HIPK2_Mmus_HIPK PS---------------------------------------------------------- HIPK1_Mmus_HIPK PS---------------------------------------------------------- DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK NS---------------------------------------------------------- F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 KS---------------------------------------------------------- Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK -KPYQNQKQNNKYKNSSNGKNSNNNTKQADMNANNNFNNNNNNNNSNNSQKFYQNNKKFR 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK -------------------HKAR------------------K------------------ HIPK3_Hsap_HIPK -----PAVSVITISSDTDEEETS------------------QRHSLRECKGSLDCEACQS HIPK2_Hsap_HIPK -----PTVSVITISSDTDEEEEQ------------------KH----------------- HIPK1_Hsap_HIPK -----PPVSVITIRSDTDEEEDN------------------KY----------------- smi35A_Dmel_DYRK2 ----------------------------AAIATTTKS--RQQ------------------ mnb_Dmel_DYRK1 ---------------------MP------------------P------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK -----PT-AVITISDSEDEGGEA------------------G------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK -------------------HKAR------------------K------------------ HIPK3_Mmus_HIPK -----PAVSVITISSDSDDEETS------------------PRPSLRECKGSLDCEACQS HIPK2_Mmus_HIPK -----PTVSVITISSDTDEEEEQ------------------KH----------------- HIPK1_Mmus_HIPK -----PPVSVITIRSDTDEEEDN------------------KY----------------- DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 -----------------------------------LG--SKL------------------ DYRK2_Mmus_DYRK2 ------------------------------------I--SKL------------------ DYRK1B_Mmus_DYRK1 ---------------------TH------------------Q------------------ DYRK1A_Mmus_DYRK1 ---------------------VY------------------N------------------ mbk-2_Cele_DYRK2 ------------------------------------T--ETL------------------ mbk-1_Cele_DYRK1 ----------F------------------------------------------------- hpk-1_Cele_HIPK -----PAPSVITLSSDEDS----------------------------------------- F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 -----------------------------------LG--SKL------------------ DYRK2_Hsap_DYRK2 ------------------------------------I--SKL------------------ DYRK1B_Hsap_DYRK1 ---------------------TH------------------Q------------------ DYRK1A_Hsap_DYRK1 ---------------------VY------------------N------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ---PH--SNISNIL---------------------------------------------- Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ---PTIPINMEEIN---------------------------------------------- 22349_Tthe_YAK RHYSD--SE--------------------------------------------------- 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ---------------------------AM-------A--LA------------------- 5356_Tthe_DYRK2 ----------------------QDVKINP-------QSQASN------------------ 5655_Tthe_DYRK2 ---------------------------MP-------S--TNL------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ----------------------P------------------A------------------ DYRK2_Spur_DYRK2 ------------------------------------V--SKL------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ---------------------VP------------------N------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ---------------------GG------------------P------------------ AqueK111_Aque_DYRK1 ---------------------RG------------------P------------------ AqueK112_Aque_DYRK2 -----------------------------------HS--QTL------------------ AqueK113_Aque_DYRK2 -----------------------------------KQ--RQL------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK -----------PP----------------------------------------------- HIPK3_Hsap_HIPK TLNIDRMCSLSSP----------------------------------------------- HIPK2_Hsap_HIPK -----------AP----------------------------------------------- HIPK1_Hsap_HIPK -----------KP----------------------------------------------- smi35A_Dmel_DYRK2 -----------PPSQ---SHG-----HAQSNGHLP--------------------D-IKL mnb_Dmel_DYRK1 -----------PP----------------------------------------------- Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK -----------GA----------------------------------------------- PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK -----------AP----------------------------------------------- HIPK3_Mmus_HIPK TLNIDRMCSLSSP----------------------------------------------- HIPK2_Mmus_HIPK -----------AP----------------------------------------------- HIPK1_Mmus_HIPK -----------KP----------------------------------------------- DYRK4_Mmus_DYRK2 ------------------AE-----EQQASKG-KK----------------------D-- DYRK3_Mmus_DYRK2 -----------PP------------------------------------------V---- DYRK2_Mmus_DYRK2 -----------PP------------------------------------------P---- DYRK1B_Mmus_DYRK1 -----------AP----------------------------------------------- DYRK1A_Mmus_DYRK1 -----------SP----------------------------------------------- mbk-2_Cele_DYRK2 -----------PN----------------------------------------------- mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------VQG----CHHSS---RK----------------------D-- DYRK3_Hsap_DYRK2 -----------PP------------------------------------------V---- DYRK2_Hsap_DYRK2 -----------PP------------------------------------------P---- DYRK1B_Hsap_DYRK1 -----------AP----------------------------------------------- DYRK1A_Hsap_DYRK1 -----------SP----------------------------------------------- YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 -----------PS-SS---SC---QNAINKYG-QKQNNA-KNYVFKNQ------NPLNSV 5655_Tthe_DYRK2 -----------PE-SK---NTETSTIQSSQIG-IKENMLKSDL--KEFNQFGIPQNL-NV 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 -----------AP----------------------------------------------- DYRK2_Spur_DYRK2 -----------PP----------------------------------------------- DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 -----------TP----------------------------------------------- CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 -----------SP----------------------------------------------- AqueK111_Aque_DYRK1 -----------SP----------------------------------------------- AqueK112_Aque_DYRK2 -----------P-SHQQKPNG----RHGSS---QP--------------------P-S-- AqueK113_Aque_DYRK2 -----------PE-A----------------------------------------P---- AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------P----------------------------------------------- GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 SASDKYNSMQKVAVRSKITSSVSDLESVQQY---SLHRIYGGVGSGSTHHVSSAATRKHL mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------EATKETTDKLKD------------------------------EAEKHL DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------EITKETTEKTKD------------------------------SPTKHV DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 TNNQ----------------------PLSQSKIEQ------------------------- 5655_Tthe_DYRK2 ---------------------------------QS------------------------- 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------DISPGSVS-YTD------------------------------SSRRRL AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK --AGS-----------KSDSN------------------FSN------------------ HIPK3_Hsap_HIPK --DS------------TLSTSSSGQSSPSPCKRPNSMSDEEQ------------------ HIPK2_Hsap_HIPK --TS------------TVSKQ------------------RKN------------------ HIPK1_Hsap_HIPK --SS------------SGLKP------------------RSN------------------ smi35A_Dmel_DYRK2 PGTGS-------------------------------------GIVG---AMSSKYGSSTL mnb_Dmel_DYRK1 --PNG------------------------------------------------------- Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK --QV------------PVLKQ------------------RAH------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK --AGS-----------KSDSN------------------FSN------------------ HIPK3_Mmus_HIPK --DS------------TLSTSSSGQSSPSPCKRPNSMSDDEQ------------------ HIPK2_Mmus_HIPK --TS------------TVSKQ------------------RKN------------------ HIPK1_Mmus_HIPK --NS------------SSLKA------------------RSN------------------ DYRK4_Mmus_DYRK2 ENSGKQQSSVEHTADTI-------------------------QLPH---LTEA------- DYRK3_Mmus_DYRK2 --VGI------------------------------------------------------- DYRK2_Mmus_DYRK2 --SSS------------------------------------------------------- DYRK1B_Mmus_DYRK1 --ISA------------------------------------------------------- DYRK1A_Mmus_DYRK1 --TNS------------------------------------------------------- mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 QHSGDQQDCLQHGADTV-------------------------QLPQ---LVDA------- DYRK3_Hsap_DYRK2 --VGI------------------------------------------------------- DYRK2_Hsap_DYRK2 --SSS------------------------------------------------------- DYRK1B_Hsap_DYRK1 --ASA------------------------------------------------------- DYRK1A_Hsap_DYRK1 --TNS------------------------------------------------------- YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK -----------------------------------------N------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 -------------------------------------------LQK---IYKY------- 5356_Tthe_DYRK2 -----AENPSSN--NL-------------------------SQIPLNQGISLQ------- 5655_Tthe_DYRK2 -----SKNASEKNKNN-------------------------MYIPSP--VNSS------- 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 --ASN------------------------------------------------------- DYRK2_Spur_DYRK2 --TGA------------------------------------------------------- DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ----------------------------------------VS------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 --GSS------------------------------------------------------- CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 --NAS------------------------------------------------------- AqueK111_Aque_DYRK1 --NAS------------------------------------------------------- AqueK112_Aque_DYRK2 HPVGS-----------D-------------------------SQPK---VLEP------- AqueK113_Aque_DYRK2 --ISN-----------N----------------------ATTAAPM---T---------- AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 --DS-------------------------------------------------------- GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------LIRLSQVSPEDDRPCRG------- HIPK3_Hsap_HIPK ------------------------------------ESSCD---TVDGSPTSDSSGHDS- HIPK2_Hsap_HIPK ------------------------------------VISCV---TVHDSPYSDSSSNTS- HIPK1_Hsap_HIPK ------------------------------------VISYV---TVNDSPDSDSS-LSS- smi35A_Dmel_DYRK2 AHNHHNVTHHNASTATIATTTHHHHHHGGQQQQQSS------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------AQSQTSGSLLQHAPSSSCS-RSSA PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------LIRLSQASPEDAGPCRG------- HIPK3_Mmus_HIPK ------------------------------------ESGCE---TVDGSPTSDSSGHDS- HIPK2_Mmus_HIPK ------------------------------------VISCV---TVHDSPYSDSSSNTS- HIPK1_Mmus_HIPK ------------------------------------VISYV---TVNDSPDSDSS-LSS- DYRK4_Mmus_DYRK2 ---------------------------SG--KSETV------------------------ DYRK3_Mmus_DYRK2 ---------------------------AS--KLK-------------------------- DYRK2_Mmus_DYRK2 ---------------------------AS--KLR-------------------------- DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ---------------------------PK--KSEAA------------------------ DYRK3_Hsap_DYRK2 ---------------------------AN--KLK-------------------------- DYRK2_Hsap_DYRK2 ---------------------------AS--KLR-------------------------- DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------GFSKF---HFNDQPSWNSN-GNS- 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ---------------------------NN--KKRI-L----------------------- 5356_Tthe_DYRK2 ---------------------------NN--KKKTDMIHL-------------------- 5655_Tthe_DYRK2 ---------------------------AN--QQKIQI----------------------- 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ---------------------------AG--KDR-------------------------- DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------ATRR-----------------NGYNKRNSLV----------------------- AqueK113_Aque_DYRK2 ---------------------------NG--KLS-------------------------- AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ---PFAES---------------------------------------------------- HIPK2_Hsap_HIPK ---PYSVQ---------------------------------------------------- HIPK1_Hsap_HIPK ---PYSTD---------------------------------------------------- smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK HQQPHPHPQQQQQQQINYGDHDPEDARRRHHAAAAAAQQQQQYQPQPPPQQVLPQPQPSI PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ---PFAEN---------------------------------------------------- HIPK2_Mmus_HIPK ---PYSVQ---------------------------------------------------- HIPK1_Mmus_HIPK ---PHPTD---------------------------------------------------- DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ---PWMIQ---------------------------------------------------- 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ----------------------------------TF--VEDTHEN--------------- HIPK2_Hsap_HIPK ----------------------------------QR--AG--HNN--------------- HIPK1_Hsap_HIPK ----------------------------------TL--SALRGNS--------------- smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ---------------------------------H-------------------------- Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK KYEPGQSQKKRILAMAQSECGYQPQVPSQPSSSASL--PHIPTKQEPAEFYPEYAAAPPQ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ----------------------------------SF--VEDAHQN--------------- HIPK2_Mmus_HIPK ----------------------------------QR--TG--HNG--------------- HIPK1_Mmus_HIPK ----------------------------------TL--SALRGNS--------------- DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ---------------------------------S-------------------------- DYRK1A_Mmus_DYRK1 ---------------------------------S-------------------------- mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ---------------------------------S-------------------------- DYRK1A_Hsap_DYRK1 ---------------------------------S-------------------------- YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ----------------------------------QQQQH--------------------- 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ---------------------------------V-------------------------- DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ---------------------------------S-------------------------- CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ---------------------------------L-------------------------- AqueK111_Aque_DYRK1 ---------------------------------L-------------------------- AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK -----TELV----------------------------------------SSADTETKPAV HIPK2_Hsap_HIPK -----ANAF--DT-----------------------------------KGSLENHCTGNP HIPK1_Hsap_HIPK -----GSVL--EG-----------------------------------PGRVVADGT-GT smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ---------------------------------------------------------GRM Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK QLDTKRSSWAPTSSGSGVSALPLAHPKREAPSVAPISYVAPSVAPPLAHSK--------- PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK -----TELG----------------------------------------TCAGPEAKPAV HIPK2_Mmus_HIPK -----TNTL--DT-----------------------------------KGGLENHCTGNP HIPK1_Mmus_HIPK -----GTLL--EG-----------------------------------PGRPAADGI-GT DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ---------------------------------------------------------T-- DYRK1A_Mmus_DYRK1 ---------------------------------------------------------S-T mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ---------------------------------------------------------S-- DYRK1A_Hsap_DYRK1 ---------------------------------------------------------S-T YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ---------------------------------------------------------NLS DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ---------------------------------------------------------H-- CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ---------------------------------------------------------H-N AqueK111_Aque_DYRK1 ---------------------------------------------------------H-N AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK CSVVVPPVEL-------------------------------------------------- HIPK2_Hsap_HIPK RTIIVPPLKT-------------------------------------------------- HIPK1_Hsap_HIPK RTIIVPPLKT-------------------------------------------------- smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 RVPA--------------IMQLQPNSYAPNSVPYYGNMSSSSVAAAAA------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK GTAVEPPVGR-------------------------------------------------- HIPK2_Mmus_HIPK RTIIVPPLKT-------------------------------------------------- HIPK1_Mmus_HIPK RTIIVPPLKT-------------------------------------------------- DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 QDSM--------------EV---------------------------G------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 QDSM--------------EV---------------------------G------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK -----------------------------------------------------QQGFNGN 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 QTVLQAPIVTMGIPTIPVTM---------------------------GMPHVHQAGIVTT DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 GGGVQV-----------------------------------------F------------ AqueK111_Aque_DYRK1 GGGVQV-----------------------------------------F------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK -----------------------------------------------SSWEEGEHL---- HIPK3_Hsap_HIPK ---ENG------------LNADEHMANTDSI------CQPLIKG--RS------------ HIPK2_Hsap_HIPK ---QASEVLVECDSLVP-VNTSHHSSSYKSK------SSSNVTS--TS------------ HIPK1_Hsap_HIPK ---QLGDC-----------TVATQASGLLSN------KTKPVAS--VS------------ smi35A_Dmel_DYRK2 --------------------------------S---------------G----------- mnb_Dmel_DYRK1 --AAAA-----------------AASHLMMT------D---S-SVISA-------SA--- Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------SS--SA------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK -----------------------------------------------SGWEEGEGR---- HIPK3_Mmus_HIPK ---ESG------------LSVDEHMANTDST------CQPLRKG--QP------------ HIPK2_Mmus_HIPK ---QASEVLVECDSLGPAISASHHSSSFKSK------SSSTVTS--TS------------ HIPK1_Mmus_HIPK ---QLGDC-----------TVATQASGLLSS------KTKPVAS--VS------------ DYRK4_Mmus_DYRK2 --------------------------------A---------------G----------- DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 -------------------------------------------------------LP--- DYRK1A_Mmus_DYRK1 --HSHH-----------------SMTSLSSS------T---TSSS-TS-------SS--- mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK -------------------------------------------N--GA------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 --------------------------------V---------------G----------- DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 -------------------------------------------------------LP--- DYRK1A_Hsap_DYRK1 --HSHH-----------------SMTSLSSS------T---TSSS-TS-------SS--- YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 -------------------------------------------NDSEEDNSKV------- Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK SESMYNDDLIGFSP----------YNNYSNDYRPQLFNKQSPPS---------------- 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------E----------- 5356_Tthe_DYRK2 -----------------------------SDFNPYESD---QFSN-TFS----------- 5655_Tthe_DYRK2 ------------------------------------------------K----------- 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 PGYVYS-----------------SHSSLENT------Q----SSS-L------------- DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 -----------------------T-SSFGSS------T---RS----Y-------RT--- CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 --YGTN-----------------SLFPQSSD------S---NFSF-QM-------SP--- AqueK111_Aque_DYRK1 --YGTN-----------------SLFPQSSD------S---NFSF-QM-------SP--- AqueK112_Aque_DYRK2 -----------------------------IDST---------------G------SVMRG AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ---------------------------------------------SPGYDGSWQHMPANG YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 -------------------------------------R---RV----------------- GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK -----------------------------------------------------------G HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ---------AS-------TMAMSH-SQ--------------------------------S mnb_Dmel_DYRK1 -----------------------------------------------------------A Dyrk3_Dmel_DYRK2 ----------G-------L----C-S---------------------------------- CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK -----------------------------------------------------------T HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ---------SE-------MSAE---QQ--------------------------------S DYRK3_Mmus_DYRK2 ---------AN-------L----M-SE--------------------------------T DYRK2_Mmus_DYRK2 ---------TN-------LA--QM-TD--------------------------------A DYRK1B_Mmus_DYRK1 -----------------------------------------------------------G DYRK1A_Mmus_DYRK1 -----------------------------------------------------------S mbk-2_Cele_DYRK2 -------------------------ID--------------------------------- mbk-1_Cele_DYRK1 ------ELDDTFQQKQRKV----D-DS--------------------------------V hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ---------AE-------VSMTSPGQS--------------------------------K DYRK3_Hsap_DYRK2 ---------AN-------L----M-SE--------------------------------T DYRK2_Hsap_DYRK2 ---------TN-------LA--QM-TD--------------------------------A DYRK1B_Hsap_DYRK1 -----------------------------------------------------------G DYRK1A_Hsap_DYRK1 -----------------------------------------------------------S YAK1_Scer_YAK ---AISK-----------R----K-EN--------------------------------T Dyrk1_Ddis_DYRK1 ------H-----------I----N-SN--------------------------------T Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK ------------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ----------------------KK-ST--------------------------------T 5356_Tthe_DYRK2 ----------------------AA-TTTNAKKTQQQFGFVQNNTPQHQNLNGIKANNFLQ 5655_Tthe_DYRK2 ----------------------AE-STKH------------SYDP--------------N 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 -----------------------------------------------------------S DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 -----------------------------------------------------------S CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ---TIM-----------------V-DD--------------------------------E AqueK110_Aque_DYRK1 -----------------------------------------------------------S AqueK111_Aque_DYRK1 -----------------------------------------------------------S AqueK112_Aque_DYRK2 GGAFPIATAGE-------TEHN---DP--------------------------------S AqueK113_Aque_DYRK2 ---------NS-------HSSQTL-LQ--------------------------------S AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK SFEAGSH-----------L----E-AG--------------------------------P YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK AS---------------------------------------------------------- HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 TG---------------------------------------------------------- mnb_Dmel_DYRK1 GG---------------------------------------------------------- Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK TS---------------------------------------------------------- HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 TS---------------------------------------------------------- DYRK3_Mmus_DYRK2 SG---------------------------------------------------------- DYRK2_Mmus_DYRK2 NG---------------------------------------------------------- DYRK1B_Mmus_DYRK1 TG---------------------------------------------------------- DYRK1A_Mmus_DYRK1 TG---------------------------------------------------------- mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 SNQISRNQ---------------------------------------------------- hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 NF---------------------------------------------------------- DYRK3_Hsap_DYRK2 NG---------------------------------------------------------- DYRK2_Hsap_DYRK2 NG---------------------------------------------------------- DYRK1B_Hsap_DYRK1 TG---------------------------------------------------------- DYRK1A_Hsap_DYRK1 TG---------------------------------------------------------- YAK1_Scer_YAK SGDISN-N---------------------------------------------------- Dyrk1_Ddis_DYRK1 SDN-----------M--------------------------------------------- Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK --------------FQQYQPEQNEIFNDIKAPFLESDQIENQSQNLGKSSDNIQEDNKQE 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 QG---------------------------------------------------------- 5356_Tthe_DYRK2 QG---------------------------------------------------------- 5655_Tthe_DYRK2 QG---------------------------------------------------------- 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 SG---------------------------------------------------------- DYRK2_Spur_DYRK2 -Q---------------------------------------------------------- DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 QG---------------------------------------------------------- CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK NGNTSR-RDVVMSNV-------------------------------------------RA AqueK110_Aque_DYRK1 SS---------------------------------------------------------- AqueK111_Aque_DYRK1 SS---------------------------------------------------------- AqueK112_Aque_DYRK2 CR---------------------------------------------------------- AqueK113_Aque_DYRK2 DQ---------------------------------------------------------- AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK SGSYSR-P---------------------------------------------------- YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ----------------------A----------EPLAILQRDEDGPN--IDNMTMEAERP HIPK3_Hsap_HIPK ------------------------------------------APGRLNQPSAVGTRQQKL HIPK2_Hsap_HIPK ------------------------------------------GHSSGSSSGAITYRQQRP HIPK1_Hsap_HIPK ------------------------------------------GQSSGCCITPTGYRAQRG smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ----------------------GQG--GGNPGQNPV------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------SS---SSSISAATAAAAA PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ----------------------T----------EPSVIPQREGDGPG--IKDRPMDAERP HIPK3_Mmus_HIPK ------------------------------------------APGKLHQPPALGARQQKP HIPK2_Mmus_HIPK ------------------------------------------GHSSGSSSGAIAYRQQRP HIPK1_Mmus_HIPK ------------------------------------------GQSSGCCITPTGYRAQRG DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ----------------------AQLPPLPRCLGRPP------------------------ DYRK1A_Mmus_DYRK1 ----------------------NQG--NQAYQNRPV------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------GS---SNSGST-T----- F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ----------------------AQLPPQPRYLGRPP------------------------ DYRK1A_Hsap_DYRK1 ----------------------NQG--NQAYQNRPV------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK RHGEESASNNSSNFNNNSNNTGNQK-------Q--------------------------- 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ----------------------N------------------------------------- 5655_Tthe_DYRK2 ----------------------N------------------------------------- 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ----------------------S--------LNMPM------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ----------------------HS------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK AAGGGARTDQQSGLGSYSGSTGNL------------------------------------ AqueK110_Aque_DYRK1 ----------------------SKG--R-------------------------------- AqueK111_Aque_DYRK1 ----------------------SKG--G-------------------------------- AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK DPE--------------------------------------------------------- HIPK3_Hsap_HIPK TSAFQ-QQ---------------------------------------------------- HIPK2_Hsap_HIPK GPHFQQQQ---------------------------------------------------- HIPK1_Hsap_HIPK GTS--AAQ---------------------------------------------------- smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 -------TPSAAAFLFPSQPAGTLYGTALGSLSDLPLPMPLPMSVPLQLPPSSSSSVSSG Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK AAAAAAAS---------------------------------------------------- PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK GPE--------------------------------------------------------- HIPK3_Mmus_HIPK AAAFP-QQ---------------------------------------------------- HIPK2_Mmus_HIPK GPHFQQQQ---------------------------------------------------- HIPK1_Mmus_HIPK GAS--AVQ---------------------------------------------------- DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 -------SPT-------------------------------------SPPPP-------- DYRK1A_Mmus_DYRK1 -------AA--------------------------------------------------- mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 -------SPT-------------------------------------SPPPP-------- DYRK1A_Hsap_DYRK1 -------AA--------------------------------------------------- YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK -NQNFKRQ---------------------------------------------------- 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ---GAYAI-------------------------------------PTHHHPSSTT----- DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 ---GAH------------------------------------------------------ AqueK111_Aque_DYRK1 ---GAH------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK -----HLNFSQVQ--------------------HFG--SGHQEWNGNFGHRRQQ------ HIPK2_Hsap_HIPK -----PLNLSQAQ--------------------QHITT------DRTGSHRRQQ------ HIPK1_Hsap_HIPK -----PLNLSQNQ--------------------QSSAAPTSQERSSNPAPRRQQ------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 SASVG----------------------------SGGVG---------------VGVVGQR Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK -----VGPPSWGP--------------------PQVYRQPSQPPPGSVGLPGST------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK -----HLNLSQVQ--------------------HFG--TGHQEWNGNFGHRRQQ------ HIPK2_Mmus_HIPK -----PLNLSQAQ--------------------QHMAA------DRTGSHRRQQ------ HIPK1_Mmus_HIPK -----PLNLSQNQ--------------------QSSSASTSQERSSNPAPRRQQ------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ----E----------------------------LMDV-----------------SLVGSP DYRK1A_Mmus_DYRK1 ----NTLDFGQNG--------------------AMDVN---------------LTVYSNP mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ----E----------------------------LMDV-----------------SLVGGP DYRK1A_Hsap_DYRK1 ----NTLDFGQNG--------------------AMDVN---------------LTVYSNP YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK -------------SYNSNKSFYGGSGGGGNNNNNNNSRPTNQNFSNSLLPSQQQ------ 22349_Tthe_YAK -----NSNYNNNQNY--------------------------------SNQKNQQ------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 -------------------------------------Q---------------QTLVNNP DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK -----------------------------------------LEKITS------------- PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------ITSPPQ------ AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------AYIPTSVTSNPFTLSHGSPNHT-----------AVHAHLAG- HIPK2_Hsap_HIPK ------------------AYITPTMAQAPYSFPHNSPSHG-----------TVHPHLAAA HIPK1_Hsap_HIPK ------------------AFVAP-LSQAPYTFQHGSPLHS-----------TGHPHLAP- smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 RH---------------IT----------------------------------------- Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------QPPPSSVAPHPHHHSHGHHHHQ-------------------- PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------AYIPTSVTSNPFTLSHGSPNHT-----------AVHAHLAG- HIPK2_Mmus_HIPK ------------------AYITPTMAQAPYTFPHNSPSHG-----------TVHPHLAA- HIPK1_Mmus_HIPK ------------------AFVAP-LSQAPYAFQHGSPLHS-----------TGHPHLAP- DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 PD---------------CS----------------------------------------- DYRK1A_Mmus_DYRK1 RQ---------------ET----------------------------------------- mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 AD---------------CS----------------------------------------- DYRK1A_Hsap_DYRK1 RQ---------------ET----------------------------------------- YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------NVIFPQ-NSPPSS----------------------------- 22349_Tthe_YAK ------------------KFKKPNQGQAQQQQQHNNTFNS-----------NSNNNN--- 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 HLHGTTTGTGGIALTSNVS----------------------------------------- DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK --------------------ISNHVKERPFCLTHGAVYQT-----------VFHHHIKN- HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------AYSGNTAAGSRYTTSYGQPQHPPPPASSNSFDTVDRRTD--- AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK -------------------------------QQHGGGGGG----------GVYAHHLCTC AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK -----------------------------YGQSHLRPAM--------------------- YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK --NTHLGGQ--------------------------------------------------- HIPK2_Hsap_HIPK AAAAHLPTQ--------------------------------------------------- HIPK1_Hsap_HIPK -APAHLPSQ--------------------------------------------------- smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK -AGTPLGGSPSSTAAAALLQPDIYAQGDIYRRPTVFVSQAAPSYAYANRAVVAPPPAH-- PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK --STHLGGQ--------------------------------------------------- HIPK2_Mmus_HIPK --AAHLPTQ--------------------------------------------------- HIPK1_Mmus_HIPK -APAHLPSQ--------------------------------------------------- DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK -----------RTGAVNPVRNDTLPMGN----------------TIKTEDILVPPTTFDG F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK -YSQNFPNQ--------------------------------------------------- 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK -IGMYVPMQ--------------------------------------------------- AqueK110_Aque_DYRK1 ------------------------------------------------------------ AqueK111_Aque_DYRK1 ------------------------------------------------------------ AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK H-----------------------QHSQSQ------------------QQVILP------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK -------------------------LFDPSSCPGEW----LSE----------PDCTLES HIPK3_Hsap_HIPK --PTLLPYP---SSATLSSAAPVAHLLAS---PC-TSRPMLQH-P-TYN-ISHPSGIVHQ HIPK2_Hsap_HIPK --PHLYTYTAP---AALGSTGTVAHLVAS---QG-SARHTVQH-------TAYPASIVHQ HIPK1_Hsap_HIPK --AHLYTYAAPTSAAALGSTSSIAHLFSP---QG-SSRHAAAY-------TTHPSTLVHQ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 --------------------------------------GPAA-QV-GISQ-SVGSGS--- Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ----------------------------N---S--SSRQVIPSHP-------LPAH--IQ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK -------------------------LFDPSSCPGEW----LSE----------PEWTLEG HIPK3_Mmus_HIPK --PTLLPYP---SSASLSSAAPVAHLLAS---PC-TSRPMLQH-P-TYN-ISHPSGIVHQ HIPK2_Mmus_HIPK --PHLYTYTAP---TALGSTGTVAHLVAS---QG-SARHTVQH-------TAYPASIVHQ HIPK1_Mmus_HIPK --PHLYTYAAPTSAAALGSTSSIAHLFSP---QG-SSRHAAAY-------TTHPSTLVHQ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 --------------------------------------PPPP-AP-APQH-PAASAL--- DYRK1A_Mmus_DYRK1 --------------------------------------GIAG-HP-TYQF-SANTGP--- mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK QLPNLQYFP-------------GSHLFDP---K--TVAGLLP------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 --------------------------------------PPHP-AP-APQH-PAASAL--- DYRK1A_Hsap_DYRK1 --------------------------------------GIAG-HP-TYQF-SANTGP--- YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------------------------------------------------------------ 22349_Tthe_YAK --NTQF------------------------------------------------------ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------SQNQS----------IYPNQIKIR 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 --------------------------------------GATS-VPYAFAL-PVQSA---- DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK -------IS---SSSSSS----------------------------------------SS HIPKb_Spur_HIPK ---------------------------------GVV------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 --------------------------------------------------------L--- CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK --PDQY------------------------------------------------------ AqueK110_Aque_DYRK1 ----------------------------------------------VPHHVTEREGV--- AqueK111_Aque_DYRK1 ----------------------------------------------VPHHVTEREGV--- AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------SDQVVTA--------------AT------------------------H AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK V------------------------------------------RG--------------- HIPK3_Hsap_HIPK VP--------------------------------------VG-LN--------------- HIPK2_Hsap_HIPK VP--------------------------------------VS-MG--------------- HIPK1_Hsap_HIPK VP--------------------------------------VS-VG--------------- smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK IP---------------------------------------------------------- PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK I------------------------------------------RG--------------- HIPK3_Mmus_HIPK VP--------------------------------------VG-IN--------------- HIPK2_Mmus_HIPK VP--------------------------------------VS-MG--------------- HIPK1_Mmus_HIPK VP--------------------------------------VS-VG--------------- DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 --RT-------------------------------------R-MT--------------- DYRK1A_Mmus_DYRK1 --AH-------------------------------------Y-MT--------------- mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 -------------------------FNPQQVSMTHGN----------------------- hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 --RT-------------------------------------R-MT--------------- DYRK1A_Hsap_DYRK1 --AH-------------------------------------Y-MT--------------- YAK1_Scer_YAK -------------------------FA-VTHSVQEGP----------------------- Dyrk1_Ddis_DYRK1 --QARI----------------------NFQVENQSN-I-------YNNNNNNNNNNNNN Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ----------------------------------------------YN------------ 22349_Tthe_YAK --QANLSNNNNNSNSSSNNNNNNSSIL-NNNSSNQGQ-I-----------QTQNMKTSQQ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 RP--------------------------------------DS-SK--------------- 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 -------------------------------------------VS--------------- DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK SP--------------------------------------LS-VI--------------- HIPKb_Spur_HIPK -IYS------------------------------------VS-LV--------------- PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 --SS-------------------------------------------------------- CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------QGYPASTST-NRHAPPAGPPVPTSFYG--------------- AqueK110_Aque_DYRK1 --RT-------------------------------------R-SG--------------- AqueK111_Aque_DYRK1 --RT-------------------------------------R-SG--------------- AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK L-PT------------------------------------DS-IT--------------- AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ----------------------------KSSSYKAGS-L-----ASY------------- YAK_a_Smoe_YAK ----------------------------------AG---------HW------------- YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK -------------------------P---------------------------------- HIPK3_Hsap_HIPK -------------------------P---------------------------------- HIPK2_Hsap_HIPK -------------------------P---------------------------------- HIPK1_Hsap_HIPK -------------------------P---------------------------------- smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 -------------------------SG--------------------------------- Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK -------------------------S---------------------------------- HIPK3_Mmus_HIPK -------------------------P---------------------------------- HIPK2_Mmus_HIPK -------------------------P---------------------------------- HIPK1_Mmus_HIPK -------------------------P---------------------------------- DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 -------------------------GG--------------------------------- DYRK1A_Mmus_DYRK1 -------------------------EG--------------------------------- mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 -------------------------GG--------------------------------- DYRK1A_Hsap_DYRK1 -------------------------EG--------------------------------- YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 NNNNNSNN---------------------------------------------------- Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ------SSNSLSKSGGNTVKNNSNTGGRPRGDSMKQRFNSTNNLLSGGSYQYQQQQQQQQ 22349_Tthe_YAK NNNNSNNS---------------------------------------------------- 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 -------------------------K---------------------------------- 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 -------------------------TG--------------------------------- DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK -------------------------P---------------------------------- HIPKb_Spur_HIPK -------------------------K---------------------------------- PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ------------------------------------------------------------ AqueK110_Aque_DYRK1 -------------------------AG--------------------------------- AqueK111_Aque_DYRK1 -------------------------AG--------------------------------- AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK -------------------------N---------------------------------- AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ------------------------------------------------------------ YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK ------------------------------------------------------------ HIPK3_Hsap_HIPK ------------------------------------------------------------ HIPK2_Hsap_HIPK ------------------------------------------------------------ HIPK1_Hsap_HIPK ------------------------------------------------------------ smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 ------------------------------------------------------------ Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK ------------------------------------------------------------ PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK ------------------------------------------------------------ HIPK3_Mmus_HIPK ------------------------------------------------------------ HIPK2_Mmus_HIPK ------------------------------------------------------------ HIPK1_Mmus_HIPK ------------------------------------------------------------ DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 ------------------------------------------------------------ DYRK1A_Mmus_DYRK1 ------------------------------------------------------------ mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ------------------------------------------------------------ hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 ------------------------------------------------------------ DYRK1A_Hsap_DYRK1 ------------------------------------------------------------ YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ---------------------------YNNSNELSPN----------------------- Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK QQQQQQQQQQQQQQQQQQQQQQQYKKDTPSLMMSPPMNGLKTSSEI-------------- 22349_Tthe_YAK ---------------------------NDQQNQHNPQ-------DNNNNFKKGQNKFKNQ 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ------------------------------------------------------------ 5655_Tthe_DYRK2 ------------------------------------------------------------ 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 ------------------------------------------------------------ DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ------------------------------------------------------------ HIPKb_Spur_HIPK ------------------------------------------------------------ PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK -----------------------------------PS----------------------- AqueK110_Aque_DYRK1 ---------------PNSR----------------------------------------- AqueK111_Aque_DYRK1 ---------------SNSR----------------------------------------- AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ------------------------------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ----------------------------L-STS--ET----------------------- YAK_a_Smoe_YAK ----------------------------F-GAG--------------------------- YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------------------------ HIPK4_Hsap_HIPK --------------RAQ-----GLP---------P--RRS---HQ--------------- HIPK3_Hsap_HIPK ----------------R-----LLP---------SPTIHQTQYKPIFPPHSYIAASP--- HIPK2_Hsap_HIPK ----------------R-----VLP---------SPTIHPSQYPAQFAHQTYISASPAST HIPK1_Hsap_HIPK ----------------S-----LLT---------SASVAPAQYQHQFATQSYIGSSRGST smi35A_Dmel_DYRK2 ------------------------------------------------------------ mnb_Dmel_DYRK1 --------------S-A-----TGA---------S----------------------SSD Dyrk3_Dmel_DYRK2 ------------------------------------------------------------ CG17090_Dmel_HIPK -----------------------------------------------------------T PRP4_Mmus_PRP4 ------------------------------------------------------------ HIPK4_Mmus_HIPK --------------RAQ-----GLP---------A--HHP---HP--------------- HIPK3_Mmus_HIPK ----------------R-----LLP---------SPTIHQTQYKPIFPPHSYIAASP--- HIPK2_Mmus_HIPK ----------------R-----VLP---------SPTIHPSQYPAQFAHQTYISASPAST HIPK1_Mmus_HIPK ----------------S-----LLT---------SASVAPAQYQHQFATQSYIGSSRGST DYRK4_Mmus_DYRK2 ------------------------------------------------------------ DYRK3_Mmus_DYRK2 ------------------------------------------------------------ DYRK2_Mmus_DYRK2 ------------------------------------------------------------ DYRK1B_Mmus_DYRK1 --------------R-P-----PLP---------P----------------------PDD DYRK1A_Mmus_DYRK1 --------------H-L-----AMR---------Q----------------------GAD mbk-2_Cele_DYRK2 ------------------------------------------------------------ mbk-1_Cele_DYRK1 ----------------------------------------------------------VN hpk-1_Cele_HIPK ------------------------------------------------------------ F22D6.5_Cele_PRP4 ------------------------------------------------------------ C36B7.2_Cele_DYRK2 ------------------------------------------------------------ C36B7.1_Cele_DYRK2 ------------------------------------------------------------ DYRK4_Hsap_DYRK2 ------------------------------------------------------------ DYRK3_Hsap_DYRK2 ------------------------------------------------------------ DYRK2_Hsap_DYRK2 ------------------------------------------------------------ DYRK1B_Hsap_DYRK1 --------------R-P-----PLP---------P----------------------PDD DYRK1A_Hsap_DYRK1 --------------H-L-----TMR---------Q----------------------GAD YAK1_Scer_YAK ------------------------------------------------------------ Dyrk1_Ddis_DYRK1 ------------------------------------------------------------ Dyrk2_Ddis_DYRK2 ------------------------------------------------------------ Prp4_Ddis_PRP4 ------------------------------------------------------------ YakA_Ddis_YAK ---G------------------IPSEEIRYQYQQQ------QLQQQFQQQQQQQQQQ--- 22349_Tthe_YAK NKKS------------------FTN---------H------KYQQQNAQ------QQ--- 10580_Tthe_DyrkP ------------------------------------------------------------ 22423_Tthe_DyrkP ------------------------------------------------------------ 5306_Tthe_DYRK2 ------------------------------------------------------------ 5356_Tthe_DYRK2 ----------------NKIEQN------------------------F------------- 5655_Tthe_DYRK2 -----------------NIEKQL-----------------------Y------------- 15575_Tthe_PRP4 ------------------------------------------------------------ DYRK1_Spur_DYRK1 --------------L-V------NS---------Q----------------------TTR DYRK2_Spur_DYRK2 ------------------------------------------------------------ DYRK4_Spur_DYRK2 ------------------------------------------------------------ HIPKa_Spur_HIPK ----------------Y-----TLT---------SPTIHWPEFQNIFKKHSR-------- HIPKb_Spur_HIPK ----------------R-----LIE----------------------------------- PRP4_Spur_PRP4 ------------------------------------------------------------ CG7028_Dmel_PRP4 ------------------------------------------------------------ CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------ CC1G_04865_Ccin_PRP4 ------------------------------------------------------------ CC1G_14245_Ccin_YAK ----------------------IVP---------SGSQ---QQRNPFNVQ------ENAQ AqueK110_Aque_DYRK1 NQKSYRHHH--HHHR-R-----TH---------------------------------PSE AqueK111_Aque_DYRK1 NQKSYRHHHHHHHHR-R-----TH---------------------------------PSE AqueK112_Aque_DYRK2 ------------------------------------------------------------ AqueK113_Aque_DYRK2 ------------------------------------------------------------ AqueK114_Aque_HIPK ----------------K-----LL------------------------------------ AqueK115_Aque_PRP4 ------------------------------------------------------------ AqueK116_Aque_PRP4 ------------------------------------------------------------ DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------ DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------ DYRKP-2_Smoe_DYRKP ------------------------------------------------------------ DYRKP-1_Smoe_DYRKP ------------------------------------------------------------ PRP4_e_Smoe_PRP4 ------------------------------------------------------------ PRP4_d_Smoe_PRP4 ------------------------------------------------------------ PRP4_b_Smoe_PRP4 ------------------------------------------------------------ PRP4_a_Smoe_PRP4 ------------------------------------------------------------ PRP4_c_Smoe_PRP4 ------------------------------------------------------------ YAK_b_Smoe_YAK ----------------------IVE---------A---------------------AESH YAK_a_Smoe_YAK ------------------------------------------------------------ YAK_d_Smoe_YAK ------------------------------------------------------------ GK031_Glam_DYRK1 ------------------------------------------------------------ GK034_Glam_DYRK2 ------------------------------------------------------------ GK033_Glam_DYRK2 ------------------------------------------------------------ GK032_Glam_DYRK2 ------------------------------------------------------------ PRP4_Hsap_PRP4 ------------------------------------------KI HIPK4_Hsap_HIPK --H------------GPPRGA-----------TSFLQHV-TGHH HIPK3_Hsap_HIPK AYT------------GFPLSP-------------TKLSQ-YPYM HIPK2_Hsap_HIPK VYT------------GYPLSP-------------AKVNQ-YPYI HIPK1_Hsap_HIPK IYT------------GYPLSP-------------TKISQ-YSYL smi35A_Dmel_DYRK2 --------------------DV------------SDRAI-FGRA mnb_Dmel_DYRK1 ASS------------SSPMVG-----------VCVQQNP-VVIH Dyrk3_Dmel_DYRK2 --------------------SR----------NESPVTG-KLDL CG17090_Dmel_HIPK QYS-----------QFGPLSPAQVAASKHAAHFAPTNIW-YGAE PRP4_Mmus_PRP4 ------------------------------------------KI HIPK4_Mmus_HIPK --H------------GPPR-T-----------TSFLQHV-GGHH HIPK3_Mmus_HIPK AYT------------GFPLSP-------------TKLSQ-YPYM HIPK2_Mmus_HIPK VYT------------GYPLSP-------------AKVNQ-YPYI HIPK1_Mmus_HIPK IYT------------GYPLSP-------------TKISQ-YSYL DYRK4_Mmus_DYRK2 --------------------SP-----------KSTNIL-PPIV DYRK3_Mmus_DYRK2 --------------------SI----------PLCSVLP-KLIS DYRK2_Mmus_DYRK2 --------------------NI----------QQRTVLP-KLVS DYRK1B_Mmus_DYRK1 PAT------------LGPRLGL----------HGVPQST-AASS DYRK1A_Mmus_DYRK1 -RE------------ESPMTG-----------VCVQQSP-VASS mbk-2_Cele_DYRK2 --------------------------------SNANILM-RKKF mbk-1_Cele_DYRK1 ----------------ANNR-E----------MEKLDYP-NNKL hpk-1_Cele_HIPK ----------------NPFL-------------DTSHIP-RAFN F22D6.5_Cele_PRP4 -----------------------------------------PIK C36B7.2_Cele_DYRK2 -LA------------DGP---------------LFAPKV-KRAA C36B7.1_Cele_DYRK2 ----------------------------------------INIQ DYRK4_Hsap_DYRK2 --------------------SL-----------KNTNVL-PPIV DYRK3_Hsap_DYRK2 --------------------SI----------PLCSVLP-KLIS DYRK2_Hsap_DYRK2 --------------------NI----------QQRTVLP-KLVS DYRK1B_Hsap_DYRK1 PAT------------LGPHLGL----------RGVPQST-AASS DYRK1A_Hsap_DYRK1 -RE------------ESPMTG-----------VCVQQSP-VASS YAK1_Scer_YAK ------------------TS-------------AFNKLH-IVEE Dyrk1_Ddis_DYRK1 -------------PPILPN--L----------KDLLPHN-NNNI Dyrk2_Ddis_DYRK2 ------------------------------------TAP-STPS Prp4_Ddis_PRP4 ------------------------------------------PF YakA_Ddis_YAK -----QIQQQLQQQQAPPQN-R----------KQVVIGS-YRET 22349_Tthe_YAK -----Q-------FSQGQK--Q----------YSPINEN-PSQS 10580_Tthe_DyrkP --------------------------------------Y-QEDQ 22423_Tthe_DyrkP ----------------------------------------PDGL 5306_Tthe_DYRK2 ---------------------T----------VSEETRN-SVVN 5356_Tthe_DYRK2 --V------------ANEDLQK----------NSNLQIQ-SGEN 5655_Tthe_DYRK2 --F------------ISQKRKQ----------HQNNQQN-IKID 15575_Tthe_PRP4 -------------------------------------NP-TKPK DYRK1_Spur_DYRK1 QAD------------DSPMVG-----------VCVQQSP-VASH DYRK2_Spur_DYRK2 --------------------DV----------SQRTVLP-KIVT DYRK4_Spur_DYRK2 ---------------------------------QSGQFL-PPIV HIPKa_Spur_HIPK --------------------C-------------ASALC-YTVF HIPKb_Spur_HIPK ----------------IPLPPCA---------LIIASSP-FESS PRP4_Spur_PRP4 ------------------------------------------KI CG7028_Dmel_PRP4 ------------------------------------------KM CC1G_13957_Ccin_DYRK2 --S------------VHSSR-V----------MNGYSST-ASTK CC1G_04865_Ccin_PRP4 -------------------------------------------G CC1G_14245_Ccin_YAK QS----------------MG-------------QPKDNR-NWPR AqueK110_Aque_DYRK1 GGA------------SGSHDDQ----------GGSMVGV-TVHQ AqueK111_Aque_DYRK1 GGA------------SGSHDDQ----------GGSMVGV-TVHQ AqueK112_Aque_DYRK2 ---------------------------------SPSTSS-PPPQ AqueK113_Aque_DYRK2 --------------------LS----------SNRTVLPKIIDR AqueK114_Aque_HIPK -----------------PLQ-------------LPAYHP-FSRL AqueK115_Aque_PRP4 -------------------------------------------I AqueK116_Aque_PRP4 -----------------------------------------KLD DYRK2_b_Smoe_DYRK2 --------------------G------------FYRSSL-STRS DYRK2_a_Smoe_DYRK2 --------------------G------------FYRSSL-STRS DYRKP-2_Smoe_DYRKP --------------------------------------E-PISS DYRKP-1_Smoe_DYRKP --------------------------------------E-PISS PRP4_e_Smoe_PRP4 -----------------------------------------VCK PRP4_d_Smoe_PRP4 -----------------------------------------VCK PRP4_b_Smoe_PRP4 -------------------------------------------K PRP4_a_Smoe_PRP4 -------------------------------------------K PRP4_c_Smoe_PRP4 -----------------------------------------VCK YAK_b_Smoe_YAK QDAGDWFPNDRLE-RFTPGF------------LRDILVL-VSAV YAK_a_Smoe_YAK ---------------LSPQV-------------CAHVNC-HFFT YAK_d_Smoe_YAK ----------------------------------------SHSR GK031_Glam_DYRK1 ------------------------------------------SH GK034_Glam_DYRK2 --A------------SAS---Q----------RPLLPAL-SPKK GK033_Glam_DYRK2 ----------------------------------------DLLL GK032_Glam_DYRK2 ------------------------------------------VY