CLUSTAL W (1.83) multiple sequence alignment PYK2_Hsap MSGVSEPL---------SRVKLGT-LRRPEGPAEPMVVVPVDVEKEDVRILKVCFYS-NS FAK_Hsap MAAAYLDPNLNHTPNSSTKTHLGTGMERSPGA--------------MERVLKVFHYFESN Fak56D_Dmel MNTAGATS-----QPPPTK--------NEINS--------------EEYLIHVH------ PYK2_Mmus MSGVSEPL---------SRVKVGT-LRRPEGPPEPMVVVPVDVEKEDVRILKVCFYS-NS FAK_Mmus MAAAYLDPNLNHTPSSSTKTHLGTGMERSPGA--------------MERVLKVFHYFESS FAK_Spur MASKAG----------------------------------------EKMMLKVY------ AqueK331_Aque MAVSTDR-----------------------VA--------------DLHVIRVL------ * :::* PYK2_Hsap FNPGKNFKLVKCTVQTEIREIITSILLSGRIGPNIRLAECYGLRLKHMKSDEIHWLHPQM FAK_Hsap SEPTTWASIIRHGDATDVRGIIQKIVDSHK----VKHVACYGFRLSHLRSEEVHWLHVDM Fak56D_Dmel -MPNKSFKAVRFNVKETVFHVIRRTVEDLGTDGRTPSIQRYACRMLNMITKEVIWLARST PYK2_Mmus FNPGKNFKLVKCTVQTEIQEIITSILLSGRIGPNIQLAECYGLRLKHMKSDEIHWLHPQM FAK_Mmus SEPTTWASIIRHGDATDVRGIIQKIVDSHK----VKHVACYGFRLSHLRSEEVHWLHVDM FAK_Spur -QPNGSFNSVKCMETTDIKSVIHAVVSKLARGE-RAFESSFAVRLQHTLSEDCHWLHRDL AqueK331_Aque -LVNGDSRSVRLDENTDVADIVYYILSRLRANLE-VAPHLFSILLEHTVSGEYHWLSSGY :: : :: : :. : : : : ** PYK2_Hsap TVGEVQDKY-------------------------ECLHVEAEWRYDLQIRYLPEDFMESL FAK_Hsap GVSSVREKY-------------------------ELAHPPEEWKYELRIRYLPKGFLNQF Fak56D_Dmel SMQKVLSHILTPGCSNVDCPNNQSELDEVLLEHGRRITDNRVWRVELRVRYVPNNIQELF PYK2_Mmus TVGEVQDKY-------------------------ECLHVEAEWRYDLQIRYLPEDFMESL FAK_Mmus GVSSVREKY-------------------------ELAHPPEEWKYELRIRYLPKGFLNQF FAK_Spur TVGQVKKKY-------------------------EAYHPAIEWKYELRVRYLPKNFHVLL AqueK331_Aque SVLDLITSH-------------------------CGSRPLHEWR---------------- : .: *: PYK2_Hsap KEDRTTLLYFYQQLRNDYMQRYASKVSEGMALQLGCLELRRFFKDMPHNALDKKSNFELL FAK_Hsap TEDKPTLNFFYQQVKSDYMLEIADQVDQEIALKLGCLEIRRSYWEMRGNALEKKSNYEVL Fak56D_Dmel EEDKATCFYYFNQVKEDFIQANVTAIDTEVAVQLCCLGIRHYFKNITVKAPDKKQHIDYI PYK2_Mmus KEDRTTLLYFYQQLRNDYMQRYASKVSEGMALQLGCLELRRFFKDMPHNALDKKSNFELL FAK_Mmus TEDKPTLNFFYQQVKSDYMQEIADQVDQEIALKLGCLEIRRSYWEMRGNALEKKSNYEVL FAK_Spur EKDKVSFFYFYDQVRCDYMNEVAELVEQDMSLQLGCLEMRRFFKDMPQIALDKKANFDYL AqueK331_Aque ------------------------------------------------------------ PYK2_Hsap EKEVGLDLFFPKQMQENL--KPKQFRKMIQQTFQQYASLREEECVMKFFNTLAGFANIDQ FAK_Hsap EKDVGLKRFFPKSLLDSV--KAKTLRKLIQQTFRQFANLNREESILKFFEILSPVYRFDK Fak56D_Dmel EKEIGFKSFLPQSVIATS--KPKNLKKLIQVGYKKVYNYNDIEYLTRFFDLLKNIYLTNF PYK2_Mmus EKEVGLDLFFPKQMQENL--KPKQFRKMIQQTFQQYASLREEECVMKFFNTLAGFANIDQ FAK_Mmus EKDVGLKRFFPKSLLDSV--KAKTLRKLIQQTFRQFANLNREESILKFFEILSPVYRFDK FAK_Spur EKEIGLKRFIPKNVIDNT--KPKNLRKLILQYFKQFANLNEEQCVFKFFEVLTTIHRFDH AqueK331_Aque -KEYGFEKFFKKSFLQSARSKKKNLSKMIQSTFQQYESLTSDGCIFQFFAILGRFNPLDI *: *:. *: :.. . * * : *:* ::: . : :** * . : PYK2_Hsap ETY-RCELI--QGWNITVDLVIGPK-GIRQLTSQDAKPTCLAEFKQIRSIRCLPLE---- FAK_Hsap ECF-KCALG--SSWIISVELAIGPEEGISYLTDKGCNPTHLADFTQVQTIQYSNSED--- Fak56D_Dmel EQF-SVTLS--SAWNISGILHVGPHIGISYQTHPQASLKNVAQFKDVVSIKTCTLPKEKL PYK2_Mmus ETY-RCELI--QGWNITVDLVIGPK-GIRQLTSQDTKPTCLAEFKQIKSIRCLPLE---- FAK_Mmus ECF-KCALG--SSWIISVELAIGPEEGISYLTDKGCNPTHLADFNQVQTIQYSNSED--- FAK_Spur EKF-KCALG----------------------------PTKMADFDQVQSVQSLST-D--- AqueK331_Aque DKFHNCAIGEESSTPLTTVVFVGPNCEVEYQIEATGERKFLVSFNDIHGIVYEPEL---- : : : . :..* :: : PYK2_Hsap ------------------E--GQAVLQLGIEGAP----------------QALSIKTSSL FAK_Hsap -------------------KDRKGMLQLKIAGAP----------------EPLTVTAPSL Fak56D_Dmel SKSGENTTEPELQNFNCNCQKIKTQIKISASNNV----------------EDLVITCNGI PYK2_Mmus ------------------E--TQAVLQLGIEGAP----------------QSLSIKTSSL FAK_Mmus -------------------KDRKGMLQLKIAGAP----------------EPLTVTAPSL FAK_Spur -------------------NDKKGLLQLKIAGANECENNFHVYGHAAVDMDSVYITTPSP AqueK331_Aque ------------------ATRGKVTLELKTS-------------------SPIVIRTAQL : ::: . : : PYK2_Hsap AEAENMADLIDGYCRLQGEHQGSLIIHPRKDGEKR------------------------- FAK_Hsap TIAENMADLIDGYCRLVNGTSQSFIIRPQKEGER-------------------------- Fak56D_Dmel NTAESIADLIDGYCRLLSKDLEFTIWHRETNASNE------------------------- PYK2_Mmus AEAENMADLIDGYCRLQGEHKGSLIMHAKKDGEKR------------------------- FAK_Mmus TIAENMADLIDGYCRLVNGATQSFIIRPQKEGER-------------------------- FAK_Spur TIAEDMADLIDGYCRLVLNTEQSLIIRAQQEGDR-------------------------- AqueK331_Aque ITAVHLSTLIDGYCQVYTTLPHSRLSNGMARGAPVEPPASIMAPNLPVEFTKSEISVVNP * :: ******:: : . . PYK2_Hsap ----------------------NSLPQ--------------------------------- FAK_Hsap -----------------------ALPS--------------------------------- Fak56D_Dmel ----------------------DSAKA--------------------------------- PYK2_Mmus ----------------------NSLPQ--------------------------------- FAK_Mmus -----------------------ALPS--------------------------------- FAK_Spur -----------------------ALPS--------------------------------- AqueK331_Aque FMMSVRWVDSFMKFISSSSGGDSTGGGVPRDKKRRGRRHREGTSGSGGRRGPLQYADSFI : PYK2_Hsap -IPMLNLE-ARRS----------------------------------------------- FAK_Hsap -IPKLANS-EKQG----------------------------------------------- Fak56D_Dmel -LPNDATLGSNKST---------------------------------------------- PYK2_Mmus -IPTLNLE-ARRS----------------------------------------------- FAK_Mmus -IPKLANS-EKQG----------------------------------------------- FAK_Spur -LPGDSRLPSTEGS-NEV------------------------------------------ AqueK331_Aque FVPSNEESAQRRSRANTDASGLYSLLKNRHSTVQDTPVDHLPVDQSPLPVDQSPVDRCSL :* .. PYK2_Hsap ------------------------------------------------------------ FAK_Hsap ------------------------------------------------------------ Fak56D_Dmel ------------------------------------------------------------ PYK2_Mmus ------------------------------------------------------------ FAK_Mmus ------------------------------------------------------------ FAK_Spur ------------------------------------------------------------ AqueK331_Aque LAHGPTPVYQRLDSVSGPSLTVQPVIRQTASCTDINDHKDGSSLLEEDQWNKGGVPVPYN PYK2_Hsap ---------HL----SESCS-IESDIYAEIP--DE--TLRRPGGPQYGIAREDVVLNRIL FAK_Hsap ---------MR----THAVSVSETDDYAEII--DEEDTYTMPSTRDYEIQRERIELGRCI Fak56D_Dmel ----------S----SQGKP-MLTDDYAEIGLLEGEGDYSTPTVRNYELDRALITPSAKI PYK2_Mmus ---------HL----SESCS-IESDIYAEIP--DE--TLRRPGGPQYGVAREEVVLNRIL FAK_Mmus ---------MR----THAVSVSETDDYAEII--DEEDTYTMPSTRDYEIQRERIELGRCI FAK_Spur --TVSGRKKLP----TIKP-GGLSDDYAEIV--DD-DDYAMPAAKDYEISRELVTLVETI AqueK331_Aque PASIGNRHC-FSEDDINNAS-SDDDDYAHVK--DPDRLMKS---LGRPLSPTDIMLADRL * **.: : : : : PYK2_Hsap GEGFFGEVYEGVYTNHK------------------------GEKINVAVKTCKKDCTLDN FAK_Hsap GEGQFGDVHQGIYMSPE------------------------NPALAVAIKTCKNCTSDSV Fak56D_Dmel GVGQFGDVYVGTYTLPKLGKGKNLAGNGKNSNSDQRNADSRPDVIQVAIKTCKANDDPEK PYK2_Mmus GEGFFGEVYEGVYTNHK------------------------GEKINVAVKTCKKDCTQDN FAK_Mmus GEGQFGDVHQGVYLSPE------------------------NPALAVAIKTCKNCTSDSV FAK_Spur GQGQFGDVHKGIYID--------------------------------------------- AqueK331_Aque GEGQFGDVHKGILYPDT------------------------TEEVAVAVKTCKPDSAPEE * * **:*: * PYK2_Hsap KEKFMSEAVIMKNLDHPHIVKLIGIIEEE-PTWIIMELYPYGELGHYLERNKNSLKVLTL FAK_Hsap REKFLQEALTMRQFDHPHIVKLIGVITEN-PVWIIMELCTLGELRSFLQVRKYSLDLASL Fak56D_Dmel TENFLAEAYIMQKFDHPHIIRLIGICSVM-PIWIVMELAKLGELRAYLKTNSERLSHGTL PYK2_Mmus KEKFMSEAVIMKNLDHPHIVKLIGIIEEE-PTWIIMELYPYGELGHYLERNKNSLKVPTL FAK_Mmus REKFLQEALTMRQFDHPHIVKLIGVITEN-PVWIIMELCTLGELRSFLQVRKYSLDLASL FAK_Spur ------------------------------------------QMRMFLQAHKDELTLASL AqueK331_Aque RVKFLQEAAIMKQFNHPHIVKLFGVVTQGLRTYIVMELAPLGQLRQYLLLNGESISQDIL :: :* . : * PYK2_Hsap VLYSLQICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASV-T FAK_Hsap ILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASK-G Fak56D_Dmel LKYCYQLSTALSYLESKKFVHRDIAARNVLVSSPTCVKLADFGLSRWVSDQSYYHSTPTV PYK2_Mmus VLYTLQICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASV-T FAK_Mmus ILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASK-G FAK_Spur ILYAYQLSMALSYLESKKFVHRDIAARNLLVVAKDNVKLGDFGLSRLLHDHSYYKASK-G AqueK331_Aque LNYIKQLCSAMVHLESKNYVHRDIAARNILLLSPDKIKLSDFGLSRWLEEADFYVASR-G : * *:. *: :*** . ******.**:*: : :**.****** : : :* :: PYK2_Hsap RLPIKWMSPESINFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLP FAK_Hsap KLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLP Fak56D_Dmel ALPIKWMSPESINFRRFTTASDVWMFGVCIWEILMLGVKPFQGVKNSDVILKLENGERLP PYK2_Mmus RLPIKWMSPESINFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLP FAK_Mmus KLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLP FAK_Spur KLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMYGVKPFQGVKNNEVIGRIENGERLP AqueK331_Aque KLPIKWMAPESINFRRFTGSSDVWMFGVCCWEILMRGVKPFMSIKNDEVIGKLERGERLP ******:********** :******.** **** * :** ::*.:** :*.*:*** PYK2_Hsap KPDLCPPVLYTLMTRCWDYDPSDRPRFTELVCSLSD------------------------ FAK_Hsap MPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLST------------------------ Fak56D_Dmel LPPNCPPRLYSLMSQCWAYEPLKRPNFKRIKETLHE------------------------ PYK2_Mmus KPELCPPVLYTLMTRCWDYDPSDRPRFTELVCSLSD------------------------ FAK_Mmus MPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLST------------------------ FAK_Spur MPAACPPTLYSVMTLCWSYEPSKRPNFKDLKTRLKKLRLQNKKASKGKLPIKWMAPESIN AqueK331_Aque LPPDCPPSLFNIMNHCWQYEPEERPSFTDIEQQLCV------------------------ * *** *:.:*. ** *:* ** *. : * PYK2_Hsap ------------------------------------------------------------ FAK_Hsap ------------------------------------------------------------ Fak56D_Dmel ------------------------------------------------------------ PYK2_Mmus ------------------------------------------------------------ FAK_Mmus ------------------------------------------------------------ FAK_Spur FRRFTSASDVWMFGVCMWEILMYGVKPFQGVKNNEVIGRIENGERLPMPAACPPTLYSVM AqueK331_Aque ------------------------------------------------------------ PYK2_Hsap ------------------------------------------------------------ FAK_Hsap ------------------------------------------------------------ Fak56D_Dmel ------------------------------------------------------------ PYK2_Mmus ------------------------------------------------------------ FAK_Mmus ------------------------------------------------------------ FAK_Spur TLCWSYEPSKRPNFKDLKTRLNLLSDLGLRATSKTQEFLSAKMRWLPDCISMQTEDDVDS AqueK331_Aque ------------------------------------------------------------ PYK2_Hsap ---------------------VYQMEKDIAMEQERNARYRTPK-------I--L------ FAK_Hsap ---------------------ILEEEKAQQEERMRMESRRQAT-------VS-W------ Fak56D_Dmel ---------------------ILIEDSINSSETLKREQRKVAS-------MS-WI----- PYK2_Mmus ---------------------IYQMEKDIAIEQERNARYRPPK-------I--L------ FAK_Mmus ---------------------ILEEEKVQQEERMRMESRRQAT-------VS-W------ FAK_Spur FLPFEEWYRWQSMPCLCDSCEILEEEKEQEDAVLKQEKRRILS--------T-------- AqueK331_Aque ---------------------ILEQEKHFNALAVSGRIRGYEVPDRPHVPIGRVPSGGAH : :. PYK2_Hsap ------------------------------------EPTAFQEPPPKPSRPKYRPPPQTN FAK_Hsap ------------------------------------DSGGSDEAPPKPSRPGYPSPRSSE Fak56D_Dmel ------------------------------------GSDDIDIPPSKPSRVMH-DPDI-T PYK2_Mmus ------------------------------------EPTTFQEPPPKPSRPKYRPPPQTN FAK_Mmus ------------------------------------DSGGSDEAPPKPSRPGYPSPRSSE FAK_Spur -------------------------------------WGFPEEPPPKPSRPGFPTYATPS AqueK331_Aque RPPHDRPPHERPPHDRPPPVTERLGGTEGPVGTYRSDDG-STEGPPLPPRSVLNRPL--- *. *.* PYK2_Hsap LLAPKLQFQVPEG---------LCASSPTLTSPMEYPSPVNSLHT--PPLHRHNVFKRHS FAK_Hsap GFYPSPQHMVQTN-------HYQVSGYPGSH---GITAMAGSIYPGQASLLDQTDSWNHR Fak56D_Dmel GLMPETTGLPQT---------YIIAQNPAVLAKLMMENQKRGINP------AA------- PYK2_Mmus LLAPKLQFQVPEG---------LCASSPTLTSPMEYPSPVNSLHT--PPLHRHNVFKRHS FAK_Mmus GFYPSPQHMVQTN-------HYQVSGYPGSH---GIPAMAGSIYQGQASLLDQTELWNHR FAK_Spur NILGD-RH-LPSN-------HYQSTQ---------------------AKVPPSTTTPNTN AqueK331_Aque --PPEPTRKTRTNGSDSTVDPYLVTTLPGRG---ATPPPARGATP------PI------- . : PYK2_Hsap MREEDFIQPSSREEAQQ-LWEAEK----VKMRQILDKQQKQMVEDYQWLRQEEKSLDPMV FAK_Hsap PQEIAMWQPNVEDSTVLDLRGIGQVLPTHLMEERLIRQQQEMEEDQRWLEKEERFLKPDV Fak56D_Dmel -----YTTPASGI--------------HNVLGEKLRQQQKDSNSDSEWLIQEELLRQRSC PYK2_Mmus MREEDFIRPSSREEAQQ-LWEAEK----IKMKQVLERQQKQMVEDSQWLRREERCLDPMV FAK_Mmus PQEMSMWQPSVEDSAALDLRGMGQVLPPHLMEERLIRQQQEMEEDQRWLEKEERFLKPDV FAK_Spur TLKGPYYSPTPLSS--------------NVMPDL-LRPMSSE--------------RPDV AqueK331_Aque -----VTTPPLAQV---VSPGVSERCFSPVPPPAIIRQQQKTR----------------- * : .. PYK2_Hsap YMNDKSPLTPE---------------KEVGYLEFTGPPQKPPRL---------------- FAK_Hsap RLSRGSIDREDGS--LQGPIGNQHIYQPVGKPDPAAPPKKPPRPGAPGHLGSLASLS--- Fak56D_Dmel SIPQGSLNDHQAQ--M--FKLDFMSAGPSSLPDCSNSSSRPMTPNA--NLSSLKSNH--- PYK2_Mmus YMNDKSPLTPE---------------KEAGYTEFTGPPQKPPRL---------------- FAK_Mmus RLSRGSIDREDGS--FQGPTGNQHIYQPVGKPDPAAPPKKPPRPGAPGHLSNLSSIS--- FAK_Spur RRTGGRMLVQEGQNGNREPYGGQPVYEAFDQKPSSA-PSTLTTSAADQYYQTTDEVRREL AqueK331_Aque ----GSYYDNEEQ-----------------------------QPGSDGYYSTVYSGN--- : PYK2_Hsap ------------------------------GAQSIQPTANLDRTDDLVYL----NVMELV FAK_Hsap --SPADSYNEGVK-----LQP-------QE--ISPPPTANLDRSNDKVYE----NVTGLV Fak56D_Dmel --SSADHLSSLTS------AEEQMGSNARNLG-SAVPSRPPNRADDEVYC----ATTLVV PYK2_Mmus ------------------------------GAQSIQPTANLDRTDDLVYH----NVMTLV FAK_Mmus --SPADSYNEGVK-----LQP-------QE--ISPPPTANLDRSNDKVYE----NVTGLV FAK_Spur PAEPSEQETTASQ-----QQPQQP--QPQPIGEQIAPTLDMDRTDDYVFE----NTTQVV AqueK331_Aque --IEEDSINRNVRDPSPYEDPEEVGV--ASGGGGVASEEEEEEDDDSVLEELLACTTGVV . :. :* * . :* PYK2_Hsap RAVLELKNELCQLPPEGYVVVVKNVGLTLRKLIGSVDDLLPSLPSSSRTEIEGTQKLLNK FAK_Hsap KAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLATVDETIPLLPASTHREIEMAQKLLNS Fak56D_Dmel KSIMALSQGVEKANTEGYLELVKNVGVKLRNLLTSVDKISIIFPAQALKEVQMAHQVLSK PYK2_Mmus EAVLELKNKLGQLPPEDYVVVVKNVGLNLRKLIGSVDDLLPSLPASSRTEIEGTQKLLNK FAK_Mmus KAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLATVDETIPALPASTHREIEMAQKLLNS FAK_Spur RAVMEMVNLVHAVKSDQYVNLVRDIGLALKSLLGSVDTLYSDLPGETHRGIQMAHKVLSS AqueK331_Aque QSIVELSTKLPAARPGDYVDLVKGVGVSLRQLLVKVDSSLDMIPEHTHSKVKMAHKVLSS .::: : : . *: :*: :*: *: *: .** :* : :: ::::*.. PYK2_Hsap DLAELINKMRLAQQNAVTSLSEECKRQMLTASHTLAVDAKNLLDAVDQAKVLAN------ FAK_Hsap DLGELINKMKLAQQYVMTSLQQEYKKQMLTAAHALAVDAKNLLDVIDQARLKM------- Fak56D_Dmel DMHELVSAMRLAQQYSDTTLDCEYRKSMLSAAHVLAMDAKNLFDVVDSIRQRYQHLFPPS PYK2_Mmus DLAELINKMKLAQQNAVTSLSEDCKRQMLTASHTLAVDAKNLLDAVDQAKVVAN------ FAK_Mmus DLGELISKMKLAQQYVMTSLQQEYKKQMLTAAHALAVDAKNLLDVIDQARLKM------- FAK_Spur DMGELINAMKLAQKYATTTLDQDYKRGMIQAGHVLAVDAKNLLDAVDTARLQAQDIFMGG AqueK331_Aque DMTQLVKSMKELQENYQSFLLDHYQKQMLQSANIIAVNSKHLLEAFSQARRSRRH----- *: :*:. *: *: : * . :: *: :.: :*:::*:*::... : PYK2_Hsap ------------------------------------------------------------ FAK_Hsap ------------------------------------------------------------ Fak56D_Dmel ATKETSCSSSFESTSGSIVAEPVNDLGGYIKTSTSGDLLQNTGIYDNDLHHSFNSQLQLQ PYK2_Mmus ------------------------------------------------------------ FAK_Mmus ------------------------------------------------------------ FAK_Spur T----------------------------------------------------------- AqueK331_Aque ------------------------------------------------------------ PYK2_Hsap --------------------------------------L------------AHPPAE FAK_Hsap --------------------------------------L------------GQTRPH Fak56D_Dmel NPKASIDLSGGGSLQRGMSLGLDTTRSTNEPLRIVEETLGSPGEHMYCNTSALHGHA PYK2_Mmus --------------------------------------L------------AHPPAE FAK_Mmus --------------------------------------L------------GQTRPH FAK_Spur --------------------------------------R------------QQEELS AqueK331_Aque -------------------------------------------------------KR