CLUSTAL W (1.83) multiple sequence alignment FGFR4_Hsap MRLL----------------------LALLGVLLSV--P--------------------- FGFR3_Hsap MGAPA-------------------CALALCVAVAI--VA--------------------- FGFR2_Hsap MGLTSTWRYGRGPGIGTVTMVSWGRFICLVVVTMATLSL--------------------- FGFR1_Hsap MWSWK-------------------CLLFWAVLVTATLCT--------------------- htl_Dmel MAAAWSWRAS----HSTITMTSG-S-LVVLFLLLSIW----------------------- btl_Dmel MAKVPIT-------------------LVMIIAIVSAAADLGCDYGHHRCYIDVTVENSPR FGFR4_Mmus MWLL----------------------LALLSIFQGT------------------------ FGFR3_Mmus MVVPA-------------------CVLVFCVAVVA------------------------- FGFR2_Mmus MGLPSTWRYGRGPGIGTVTMVSWGRFICLVLVTMATLSL--------------------- FGFR1_Mmus MWGWK-------------------CLLFWAVLVTATLCT--------------------- egl-15_Cele MSYFL-------------------AS-CLGVGLLSTV----------------------- FGFR_Spur MPEC---------------------TYVQFEMVSASLFD--------------------- * FGFR4_Hsap --------------GPPV------------------------------------------ FGFR3_Hsap --------------GASS------------------------------------------ FGFR2_Hsap --------------ARPS------------------------------------------ FGFR1_Hsap --------------ARPS------------------------------------------ htl_Dmel ---------------QP------------------------------------------- btl_Dmel QRHLLSDMDITLQCVRPMAKWFYEDKFQLRATLLRLERAQSGNSGNYGCLDSQNRWYNIS FGFR4_Mmus ----------------PA------------------------------------------ FGFR3_Mmus --------------GATS------------------------------------------ FGFR2_Mmus --------------ARPS------------------------------------------ FGFR1_Mmus --------------ARPA------------------------------------------ egl-15_Cele -----------------S------------------------------------------ FGFR_Spur --------------LPPP------------------------------------------ FGFR4_Hsap -------------LS--------------------------------------------- FGFR3_Hsap -------------ES--------------------------------------------- FGFR2_Hsap -------------FS--------------------------------------------- FGFR1_Hsap -------------PT--------------------------------------------- htl_Dmel ------------------------------------------------------------ btl_Dmel LVVGHKEPVGNDIAS--------------------------------------------- FGFR4_Mmus -------------LS--------------------------------------------- FGFR3_Mmus -------------EP--------------------------------------------- FGFR2_Mmus -------------FS--------------------------------------------- FGFR1_Mmus -------------PT--------------------------------------------- egl-15_Cele -------------CS--------------------------------------------- FGFR_Spur -------------PPPPFILYEICMRYCACLPDQCMLIVNDACPITMEIFHVGGRPGRPV FGFR4_Hsap ---LEASEEVELEPCLAPSLE--------------------------------------- FGFR3_Hsap ---LGTEQRVVGRAAEVPGP---------------------------------------- FGFR2_Hsap ---L--VEDTTLEPEEPPTKY--------------------------------------- FGFR1_Hsap ---L--PEQ------AQPWG---------------------------------------- htl_Dmel -----------A-----------VQ----------------------------------- btl_Dmel ---FVKLEDAPALPESDLFFQPLNESRSLKLLQPLPKTVQRTAGGLFQLNCSPMDPDAKG FGFR4_Mmus ---LEASEEMEQEPCLAPILE--------------------------------------- FGFR3_Mmus ---PGPEQRVVRRAAEVPGP---------------------------------------- FGFR2_Mmus ---L--VEDTTLEPEEPPTKY--------------------------------------- FGFR1_Mmus ---L--PEQ------AQPWG---------------------------------------- egl-15_Cele ---LQGLT--SHYRENIPRF---------------------------------------- FGFR_Spur HLVLIQAVSFNINPSLPPTLR--------------------------------------- FGFR4_Hsap ------------------------------------------------------------ FGFR3_Hsap ------------------------------------------------------------ FGFR2_Hsap ------------------------------------------------------------ FGFR1_Hsap ------------------------------------------------------------ htl_Dmel -----------V-EG-RRQM---------------------------------------- btl_Dmel VNISWLHNDTQILGGRGRIKLKRWSLTVGQLQPEDAGSYHCELCVEQDCQRSNPTQLEVI FGFR4_Mmus ------------------------------------------------------------ FGFR3_Mmus ------------------------------------------------------------ FGFR2_Mmus ------------------------------------------------------------ FGFR1_Mmus ------------------------------------------------------------ egl-15_Cele ------------------------------------------------------------ FGFR_Spur ------------------------------------------------------------ FGFR4_Hsap -----------QQEQELTVALGQPVRLCCGRAE----RGGHWYKEGSRLAPAG------- FGFR3_Hsap ---------EPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSE------- FGFR2_Hsap ---------QISQPEVYVAAPGESLEVRCLLKDA---AVISWTKDGVHLGPNN------- FGFR1_Hsap ---------APVEVESFLVHPGDLLQLRCRLRDD--VQSINWLRDGVQLAESN------- htl_Dmel ------------------------ANSQ------------EMIKDHLGAR---------- btl_Dmel SRKHTVPMLKPGYPRNTSIALGDNVSIECLLEDSALEPKITWLHKGNADNIDD---LLQR FGFR4_Mmus -----------QQEQVLTVALGQPVRLCCGRTE----RGRHWYKEGSRLASAG------- FGFR3_Mmus ---------EPSQQEQVAFGSGDTVELSCHPPGGAPTGPTVWAKDGTGLVASH------- FGFR2_Mmus ---------QISQPEAYVVAPGESLELQCMLKDA---AVISWTKDGVHLGPNN------- FGFR1_Mmus ---------VPVEVESLLVHPGDLLQLRCRLRDD--VQSINWLRDGVQLVESN------- egl-15_Cele ---------KHVANERYEVFLGDEIKFDCQTAASKISAFVEWYRNDKLLKNDQIDKD--- FGFR_Spur ----------RNFKGLVEKSLGFEHKIPCPVKAD-PRPYTRWLKNGTDLTPND-PDD--- :. FGFR4_Hsap ----------RVRG-----WRGRLEIASFLPEDAGRYLCLARG-SMIV------------ FGFR3_Hsap ----------RVLV-----GPQRLQVLNASHEDSGAYSCRQRL-TQRV------------ FGFR2_Hsap ----------RTVL-----IGEYLQIKGATPRDSGLYACTASRTVDSE------------ FGFR1_Hsap ----------RTRI-----TGEEVEVQDSVPADSGLYACVTSSPSGSD------------ htl_Dmel -----------------------------------------------------------S btl_Dmel LREQSQLPVDVTRLITRMDEPQVLRLGNVLMEDGGWYICIAENQVGRTVAASYVDLYSPS FGFR4_Mmus ----------RVRG-----WRGRLEIASFLPEDAGRYLCLARG-SMTV------------ FGFR3_Mmus ----------RILV-----GPQRLQVLNASHEDAGVYSCQHRL-TRRV------------ FGFR2_Mmus ----------RTVL-----IGEYLQIKGATPRDSGLYACTAARTVDSE------------ FGFR1_Mmus ----------RTRI-----TGEEVEVRDSIPADSGLYACVTSSPSGSD------------ egl-15_Cele ----------KIRKD---NNRMMLHLKNIDVSDQGLWSCRVHNAYGQI------------ FGFR_Spur ----------NVSF-----TKTSIVFKRLRFSDAGLYTCVASNFFGQPI----------- FGFR4_Hsap ---L--QNLTLITGDS-------------------------------------------- FGFR3_Hsap ---L--CHFSVRVTDA-------------------------------------------- FGFR2_Hsap ---T--WYFMVNVTDA-------------------------------------------- FGFR1_Hsap ---T--TYFSVNVSDA-------------------------------------------- htl_Dmel QNKT--PAITNNANQS-------------------------------------------- btl_Dmel DTTTVRTTTTTTVASP-------------------------------------------- FGFR4_Mmus ---V--HNLTLLMDDS-------------------------------------------- FGFR3_Mmus ---L--CHFSVRVTDA-------------------------------------------- FGFR2_Mmus ---T--WYFMVNVTDA-------------------------------------------- FGFR1_Mmus ---T--TYFSVNVSDA-------------------------------------------- egl-15_Cele ---S--RNFTVEVIDFCDYFLFPDIHHLNIPMECVCLWKYNKEAKRSDVNYAAVTGEVCS FGFR_Spur ---H--VNFTLIVVDT-------------------------------------------- . FGFR4_Hsap ------------------------------------------------------------ FGFR3_Hsap ------------------------------------------------------------ FGFR2_Hsap ------------------------------------------------------------ FGFR1_Hsap ------------------------------------------------------------ htl_Dmel ------------------------------------------------------------ btl_Dmel ---------------------------------------------------------I-- FGFR4_Mmus ------------------------------------------------------------ FGFR3_Mmus ------------------------------------------------------------ FGFR2_Mmus ------------------------------------------------------------ FGFR1_Mmus ------------------------------------------------------------ egl-15_Cele KYASRMINRARKPLPMIPCFGDHCKEFDTTPVSDFGLPGKPEDDPLVKRVVLKKDDVIVP FGFR_Spur ------------------------------------------------------------ FGFR4_Hsap -------L-------TSSNDDEDPKSH-R--DP----SNR-HSY-----------PQQAP FGFR3_Hsap -------P-------SSG-DDEDGEDE--AEDT----GV----------------DTGAP FGFR2_Hsap -------I-------SSG-DDEDDTDG--AEDF----VSE-NSN-----------NKRAP FGFR1_Hsap -------L-------PSSEDDDDDDDS-SSEEK----ETD-NTK--------PNRMPVAP htl_Dmel --------------STSSADLDDG-AA-DDDDN----KADLPVN-----------VSSKP btl_Dmel -------P------TASTGEDNDD-DV---ENP----AAE-ASG-----------GVGPP FGFR4_Mmus -------L-------TSISNDEDPKTL-S--SS----SSG-HVY-----------PQQAP FGFR3_Mmus -------P-------SSG-DDEDGEDV--AED------------------------TGAP FGFR2_Mmus -------I-------SSG-DDEDDTDS--SEDV----VSE-NRS-----------NQRAP FGFR1_Mmus -------L-------PSSEDDDDDDDS-SSEEK----ETD-NTK--------PNRRPVAP egl-15_Cele VHDSEESPSESRTEFINADEKENKEDE--EEDY----SVSQPVAPDAGLTELNITAEEPP FGFR_Spur -------H-------SESYAESSVLESFSSLELETGPYNETEEE-----------ETHFP . .. . * FGFR4_Hsap YWTHPQRM--EKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHG-ENRIGGIRLRH FGFR3_Hsap YWTRPERM--DKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRG-EHRIGGIKLRH FGFR2_Hsap YWTNTEKM--EKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQ-EHRIGGYKVRN FGFR1_Hsap YWTSPEKM--EKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKP-DHRIGGYKVRY htl_Dmel YWRNPKKM---SFLQTRPSGSLLTLNCHALGNPEPNITWYRNGTVDW----TRGYGSLKR btl_Dmel VFRK--EL---KRLQHSLSGNTVNLACPVYGKA--NITWTKDKKPLN----RELGVYV-Q FGFR4_Mmus YWTHPQRM--EKKLHAVPAGNTVKFRCPAAGNPMPTIHWLKDGQAFHG-ENRIGGIRLRH FGFR3_Mmus YWTRPERM--DKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGKEFRG-EHRIGGIKLRH FGFR2_Mmus YWTNTEKM--EKRLHAVPAANTVKFRCPAGGNPTPTMRWLKNGKEFKQ-EHRIGGYKVRN FGFR1_Mmus YWTSPEKM--EKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKP-DHRIGGYKVRY egl-15_Cele YFKSNDNIVLFNETHALPAGRTLKLNCRAKGYPEPQIIWYKNGKMLKKSSARSGGYEFKF FGFR_Spur RFTDTERM--EPE-KPLPSNTKVRLECGARGTPTPNITWIKDGVQKWK-INVIRPTRVEE : .: : : : * * . : * :: . FGFR4_Hsap QHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVG FGFR3_Hsap QQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLG FGFR2_Hsap QHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVG FGFR1_Hsap ATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALG htl_Dmel NRWTLTMEDLVPGDCGNYTCKVCNSLGCIRHDTQVIVSDRVNHKPILMTG-PLNLTLVVN btl_Dmel KNWTLRFVEATSEDSGLYNCKVCNAWGCIQFDFSVQINDRTRSAPIIVV--PQNQTVKVN FGFR4_Mmus QHWSLVMESVVPSDRGTYTCLVENSLGSIRYSYLLDVLERSPHRPILQAGLPANTTAVVG FGFR3_Mmus QQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAILG FGFR2_Mmus QHWSLIMESVVPSDKGNYTCLVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVG FGFR1_Mmus ATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALG egl-15_Cele NRWSLEVEDAVVADSGEFHCEALNKVGSAKKYFHVIIVNRMRRPPIIVPNILANQSVNIN FGFR_Spur KGFVLIIRRAIVRDTGKYTCIVSNQYGTIEHTYDVKIRERLPVKPIMSP--MKNVTATVG : : . * * : * . * * . : : :* **: * : :. FGFR4_Hsap SDVELLCKVYSDAQPHIQWLKHIVINGSSFGA-DGFPYVQVLKTADI------------- FGFR3_Hsap SDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP-DGTPYVTVLKSWIS------------- FGFR2_Hsap GDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGP-DGLPYLKVLKHSGI------------- FGFR1_Hsap SNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGP-DNLPYVQILKTAGV------------- htl_Dmel STGSMHCKYLSDLTSKKAWIFV-PCHGMTNCS----------NNRSI------------- btl_Dmel GSLVMKCTVYSDLHPTVSWKRVVLKNASLDGL----KSVEIQNLNFT------------- FGFR4_Mmus SDVELLCKVYSDAQPHIQWLKHVVINGSSFGA-DGFPYVQVLKTTDI------------- FGFR3_Mmus SDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP-DGTPYVTVLKTAGA------------- FGFR2_Mmus GDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGP-DGLPYLKVLKAAGV------------- FGFR1_Mmus SNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGP-DNLPYVQILKTAGV------------- egl-15_Cele DTATFHCKVVSDLLPHIIWVRINKINGSYSYY-NNSAEEYMFNYTEM------------- FGFR_Spur SNTSFVCRVVSDLTPHFAWMRFNGTNNTKQRLTDIDDHISILQQRWVEEPMLTCDEFLDV . : * ** . * : : FGFR4_Hsap --------------------NSS---------EVEVLYLRNVSAEDAGEYTCLAGNSIGL FGFR3_Hsap --------------------ESVE-------AD-VRLRLANVSERDGGEYLCRATNFIGV FGFR2_Hsap --------------------NSS---------NAEVLALFNVTEADAGEYICKVSNYIGQ FGFR1_Hsap --------------------NTTD-------KEMEVLHLRNVSFEDAGEYTCLAGNSIGL htl_Dmel --------------------IAE---------DKDQLDFVNVRMEQEGWYTCVESNSLGQ btl_Dmel --------------------VTN---------DSVVLTLRNVTFDQEGWYTCLASSGLGR FGFR4_Mmus --------------------NSS---------EVEVLYLRNVSAEDAGEYTCLAGNSIGL FGFR3_Mmus --------------------NTTD-------KELEVLSLHNVTFEDAGEYTCLAGNSIGF FGFR2_Mmus --------------------NTTD-------KEIEVLYIRNVTFEDAGEYTCLAGNSIGI FGFR1_Mmus --------------------NTTD-------KEMEVLHLRNVSFEDAGEYTCLAGNSIGL egl-15_Cele --------------------DTFDKAHVHHVGDESTLTIFNVSLDDQGIYACLSGNSLGM FGFR_Spur FYQNQSKRMLECLHLIQLETQGGM-------EEANQLKLYNVQYEDEGPYLCVAGNFYGM : * : ** : * * * . * FGFR4_Hsap SYQSAWLTVLPEEDP-------TWTAAAPEA----------RYTD--IILYASGSLALAV FGFR3_Hsap AEKAFWLSVHGPRAAEE----ELVEADEAGS----------VYAG--ILSYGVGFFLFIL FGFR2_Hsap ANQSAWLTVLPKQQAPG----REKEI-TASP----------DYLE--IAIYCIGVFLIAC FGFR1_Hsap SHHSAWLTVLEALEE-------RPAV-MTSP----------LYLE--IIIYCTGAFLISC htl_Dmel SNSTAYLRVVRSLHVLE-----AGVA--SGS----------LHSTSFVYIFVFGGLIFIF btl_Dmel SNSSVYLRVVSPLPPLE-----IYALLHAHP----------LGFT-LAAITIV--ALFLL FGFR4_Mmus SYQSAWLTVLPEEDL-------TWTTATPEA----------RYTD--IILYVSGSLVLLV FGFR3_Mmus SHHSAWLVVLPAE---E----ELMETDEAGS----------VYAG--VLSYGVVFFLFIL FGFR2_Mmus SFHSAWLTVLPAPVR-------EKEI-TASP----------DYLE--IAIYCIGVFLIAC FGFR1_Mmus SHHSAWLTVLEALEE-------RPAV-MTSP----------LYLE--IIIYCTGAFLISC egl-15_Cele SMANATLTVNEFMAIHLLTGDEPKIDRWTTS----------DY--IF--TTILLFLLLAA FGFR_Spur SWEGAYLDVVEPTTQ-------APVRTNPPAVYIPNNMQPTSKTQ--LIIFSVVGFVVVL : * * . . . FGFR4_Hsap LLLLAGLYRGQALHGRHP--RPPAT-VQKLS-RFPL-ARQFS--LESGSSGKSS-S---- FGFR3_Hsap VVAAVTLCRLRSPPKKGL---GSPT-VHKIS-RFPL-KRQVS--LESNASMSSN-T---- FGFR2_Hsap MVVTVILCRMKNTTKKPDF-SSQPA-VHKLTKRIPL-RRQVTVSAESSSSMNSN-T---- FGFR1_Hsap MVGSVIVYKMKSGTKKSDF-HSQMA-VHKLAKSIPL-RRQVTVSADSSASMNSG-V---- htl_Dmel MTTLFVFYAIRKMKHEKVLKQRIET-VHQWTKKVII-FKPEG-GGDSSGSMDTMIM---- btl_Dmel G-SAFITFMLRRLRREKLLKLRIET-VHQWTKKVII-YRPGGEEGSGCSSGDLQ-M---- FGFR4_Mmus LLLLAGVYHRQVIRGHYS--RQPVT-IQKLS-RFPL-ARQFS--LESRSSGKSS-L---- FGFR3_Mmus VVAAVILCRLRSPPKKGL---GSPT-VHKVS-RFPL-KRQVS--LESNSSMNSN-T---- FGFR2_Mmus MVVTVIFCRMKTTTKKPDF-SSQPA-VHKLTKRIPL-RRQVTVSAESSSSMNSN-T---- FGFR1_Mmus MLGSVIIYKMKSGTKKSDF-HSQMA-VHKLAKSIPL-RRQVTVSADSSASMNSG-V---- egl-15_Cele TLFGILFMVCKQTLHKKGFMDDTVGLVARKK-RVVVSKRPMNE--DNENSDDEP-SPYQI FGFR_Spur ILVTCIAILCKQTQVRHRRPSDKP----DISGPKHL-YRQTS--VDSTQS---I-A---- : . : : .. * FGFR4_Hsap -----SLV-----RG--VRL--SS--S-GPALLAGLVSLDLPLDPLWEFPRDRLVLGKPL FGFR3_Hsap -----PLV-----RI--ARL--SS--G-EGPTLANVSELELPADPKWELSRARLTLGKPL FGFR2_Hsap -----PLV-----RIT-TRL--SS--TADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPL FGFR1_Hsap -----LLV-----RP--SRL--SS--S-GTPMLAGVSEYELPEDPRWELPRDRLVLGKPL htl_Dmel -----PVV-----RIQKQRTTV--LQNG--NEPAPFNEYEFPLDSNWELPRSHLVLGATL btl_Dmel -----PVI-----RIEKQRTTVSTTGTGGTDPAQGFNEYEFPLDSNWEIPRQQLSLGSIL FGFR4_Mmus -----SLV-----RG--VRL--SS--S-GPPLLTGLVNLDLPLDPLWEFPRDRLVLGKPL FGFR3_Mmus -----PLV-----RI--ARL--SS--G-EGPVLANVSELELPADPKWELSRTRLTLGKPL FGFR2_Mmus -----PLV-----RIT-TRL--SS--TADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPL FGFR1_Mmus -----LLV-----RP--SRL--SS--S-GTPMLAGVSEYELPEDPRWELPRDRLVLGKPL egl-15_Cele QIIETPITKKEAARKQRKRM--NS---E----NTVLSEYEVDSDPVWEVERSKLSLVHML FGFR_Spur -----PLF-----GGR-NRL--TS--S-----LTVISEYDIPLDPEWEFPRDRLTVGKTI : * . . :. *. **. * :* : : FGFR4_Hsap GEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNI FGFR3_Hsap GEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNI FGFR2_Hsap GEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNI FGFR1_Hsap GEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNI htl_Dmel GEGAFGRVVMAEV---------NNAIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINI btl_Dmel GEGAFGRVVMAEAEGLPRSPQLAETIVAVKMVKEEHTDTDMASLVREMEVMKMIGKHINI FGFR4_Mmus GEGCFGQVVRAEAFGMDPSRPDQTSTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNI FGFR3_Mmus GEGCFGQVVMAEAIGIDKDRTAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNI FGFR2_Mmus GEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNI FGFR1_Mmus GEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNI egl-15_Cele GEGAFGEVWKATY----KETENNEIAVAVKKLKMSAHEKELIDLVSEMETFKVIGEHENV FGFR_Spur GEGAFGKVVIGEAVGIVC--QEKTSTVAVKMLKANAMDREFSDLISELAMMKMIGKNPNI ***.**.* . **** :* : :: .*: *: :*:**.: *: FGFR4_Hsap INLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDG----------------- FGFR3_Hsap INLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDT----------------- FGFR2_Hsap INLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDI----------------- FGFR1_Hsap INLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNP----------------- htl_Dmel INLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSS--------------QP btl_Dmel INLLGCCSQGGPLWVIVEYAPHGNLKDFLKQNRPGAPQRRSDSDGYL-----------DD FGFR4_Mmus INLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDG----------------- FGFR3_Mmus INLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGMDYSFDA----------------- FGFR2_Mmus INLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDI----------------- FGFR1_Mmus INLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNP----------------- egl-15_Cele LRLIGCCTGAGPLYVVVELCKHGNLRDFLRAHRPKEEKAKKSSQELTDYLEPRKASDKDD FGFR_Spur INLLGCCTQEGPPYVIVEFAHHGNLRDFLRSRRPPE-EYEKSI----------------- :.*:* *: ** :*:** . :***:::* .** . . FGFR4_Hsap -PRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLAR FGFR3_Hsap -CKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLAR FGFR2_Hsap -NRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLAR FGFR1_Hsap -SHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLAR htl_Dmel PPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLAR btl_Dmel KPLISTQHLGEKELTKFAFQIARGMEYLASRRCIHRDLAARNVLVSDGYVMKIADFGLAR FGFR4_Mmus -PRSSEGPLSFPALVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDDVMKIADFGLAR FGFR3_Mmus -CRLPEEQLTCKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLAR FGFR2_Mmus -NRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLAR FGFR1_Mmus -SHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLAR egl-15_Cele IELI--PNLTQRHLVQFAWQVAQGMNFLASKKIIHRDLAARNVLVGDGHVLKISDFGLSR FGFR_Spur -LLTTSQTLTNKDLMSMAYQVARGMDFLASKKCIHRDLAARNVLVTEDFEMKICDFGLAR : * . : *:*:**::* *:: ************ :. :**.****:* FGFR4_Hsap GVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGI-P FGFR3_Hsap DVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGI-P FGFR2_Hsap DINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGI-P FGFR1_Hsap DIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGV-P htl_Dmel DIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMS btl_Dmel DIQDTEYYRKNTNGRLPIKWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQPYPHILS FGFR4_Mmus GVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGI-P FGFR3_Mmus DVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGI-P FGFR2_Mmus DINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGI-P FGFR1_Mmus DIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGV-P egl-15_Cele DVHCNDYYRKRGNGRLPIKWMALEALDSNVYTVESDVWSYGVLLWEIMTLGGTPYPTI-A FGFR_Spur DIHYIDFYRKTTDGRLPVKWMAPEALFDRMFTTQSDVWSFGILLWEIMTLGGTPYPSV-P .:: ::*:* :****:**** *:* .. : :*****:*:*:***:* * *** : . FGFR4_Hsap VEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLL-AV--- FGFR3_Hsap VEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTS--- FGFR2_Hsap VEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTT--- FGFR1_Hsap VEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTS--- htl_Dmel AEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQ--T--- btl_Dmel AEELYSYLITGQRMEKPAKCSLNIYVVMRQCWHFESCARPTFAELVESFDGILQQASSNP FGFR4_Mmus VEELFSLLREGHRMERPPNCPSELYGLMRECWHAAPSQRPTFKQLVEALDKVLL-AV--- FGFR3_Mmus VEELFKLLKEGHRMDKPASCTHDLYMIMRECWHAVPSQRPTFKQLVEDLDRILTVTS--- FGFR2_Mmus VEELFKLLKEGHRMDKPTNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTT--- FGFR1_Mmus VEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTS--- egl-15_Cele MPELYANLKEGYRMEPPHLCPQEVYHLMCSCWREKLEERPSFKTIVDYLDWMLTMTN--- FGFR_Spur VEQMFDYLRSGKRLEKPQNTSLEIYHILCECWRTSPGQRPTFCELVEDLDRIISVSS--- ::: * * *:: * . ::* :: .**: **.* :*: :* :: FGFR4_Hsap SEEYLDLRLTFGPYSPSGGDA------------------------------SS-TCSS-S FGFR3_Hsap TDEYLDLSAPFEQYSPGGQDT------------------------------PSS-SSSGD FGFR2_Hsap NEEYLDLSQPLEQYSPSYPDT------------------------------RSS-CSSGD FGFR1_Hsap NQEYLDLSMPLDQYSPSFPDT------------------------------RSSTCSSGE htl_Dmel KEDYLDVDIANLDTPPSTSDE------------------------------EEDE-T--- btl_Dmel NDAYLDLSMPMLETPPSSGDE------------------------------DDGS-D--T FGFR4_Mmus SEEYLDLRLTFGPFSPSNGDA------------------------------SS-TCSS-S FGFR3_Mmus TDEYLDLSVPFEQYSPGGQDT------------------------------PSS-SSSGD FGFR2_Mmus NEEYLDLTQPLEQYSPSYPDT------------------------------RSS-CSSGD FGFR1_Mmus NQEYLDLSIPLDQYSPSFPDT------------------------------RSSTCSSGE egl-15_Cele --ETIEGSQEFNDQFFSERSTASGPVSPMESFQKKRKHRPLSAPVNLPSEPQHTICDD-Y FGFR_Spur NQDYLDLEAVGDAPVKTFQES------------------------------ERM------ :: . FGFR4_Hsap DSVFSHDPLPLGSS--------------------SF----PFGSGVQT FGFR3_Hsap DSVFAHDLLPPAP---------------------------PSSGGSRT FGFR2_Hsap DSVFSPDPMPYEPC-L-----------------PQYP---HINGSVKT FGFR1_Hsap DSVFSHEPLPEEPC-L-----------------PRHPAQLANGGLKRR htl_Dmel DN---------------------------------------LQKWCNY btl_Dmel ETFRETS-----PL--------------------R-----YQYTYKFN FGFR4_Mmus DSVFSHDPLPLEPS--------------------PF----PFSDSQTT FGFR3_Mmus DSVFTHDLLPPGP---------------------------PSNGGPRT FGFR2_Mmus DSVFSPDPMPYEPC-L-----------------PQYP---HINGSVKT FGFR1_Mmus DSVFSHEPLPEEPC-L-----------------PRHPTQLANSGLKRR egl-15_Cele ESNFSVEP-PNDPNHLYCNDNMLKNHIITPETSQRIPSNNNSMSKPEF FGFR_Spur --AFMGFRAPLSPQ-V------------Y----YKVPQT-RDCCPYAN