CLUSTAL W (1.83) multiple sequence alignment RHOK_Hsap_GRK M-DFGSLETVVANSAFIAARGSFDGSSSQPSRDKKYLAKLKLPPLSKCE--SLRDSLSLE GPRK7_Hsap_GRK MVDMGALDNLIANTAYLQARKPS--DCDSKELQRR-RRSLALPGLQGCA--ELRQKLSLN GPRK6_Hsap_GRK M----ELENIVANTVLLKAREGG--GGNRKGKSKKWRQMLQFPHISQCE--ELRLSLERD GPRK5_Hsap_GRK M----ELENIVANTVLLKAREGG--GGKRKGKSKKWKEILKFPHISQCE--DLRRTIDRD GPRK4_Hsap_GRK M----ELENIVANSLLLKARQGG--YGKKSGRSKKWKEILTLPPVSQCS--ELRHSIEKD Gprk1_Dmel_BARK MA---DLEAVLADVSYLMAMEKS--KCTPAARASK-KLNLPDPSVRSVMYKYLEKEGELN Gprk2_Dmel_GRK M----ELENIVANTVYLKAREGG--SDSNKGKSKKWRKILQFPHISQCI--NLKDKLDIS GPRK6_Mmus_GRK M----ELENIVANTVLLKAREGG--GGNRKGKSKKWRQMLQFPHISQCE--ELRLSLERD GPRK5_Mmus_GRK M----ELENIVANTVLLKAREGG--GGKRKGKSKKWKEILKFPHISQCE--DLRRTIDRD GPRK4_Mmus_GRK M----ELENFVANNLLLKARLGF---NKQTGRSKKWRELLKFPPVSMCT--ELRWSIEKD BARK2_Mmus_BARK MA---DLEAVLADVSYLMAMEKS--KTAPAARASK-KVVLPEPSIRSVMQRYLAERNEIT BARK1_Mmus_BARK MA---DLEAVLADVSYLMAMEKS--KATPAARASK-KILLPEPSIRSVMQKYLEDRGEVT F19C6.1_Cele_GRK M----EIENIVANTVYIKARESG--G-QKKGKSKKWKNYLQFPHYTECL--PLKTEIEVT BARK1_Hsap_BARK MA---DLEAVLADVSYLMAMEKS--KATPAARASK-KILLPEPSIRSVMQKYLEDRGEVT BARK2_Hsap_BARK MA---DLEAVLADVSYLMAMEKS--KATPAARASK-RIVLPEPSIRSVMQKYLAERNEIT RHOK_Mmus_GRK M-DFGSLETVVANSAFIAARGSFDGSSTPSSRDKKYLAKLRLPPLSKCE--GLRDNLSLE W02B3.2_Cele_BARK MA---DLEAVLADVSYLMAMEKS--RSQPAARASK-RIVLPDPSVRSIMQKFLEKSGDMK BARK_Spur_BARK MA---DLEAVLADVSYLMAMEKS--KSTPAARASK-KLVLPDPSVRTVMYKYLEERKEIT GPRK_Spur_GRK ------------------------------------------------------------ AqueK007_Aque_BARK MA---DLESVLADVSYLMTIEKS--R-NPGAKTLK-KIVLPDNSVHDVVHKWLSFKNELN AqueK008_Aque_GRK --------------------------------------MLKLPPVGTCL--PLRDKIDHT RHOK_Hsap_GRK FESVCLEQPIGKKLFQQFLQSA-EKHLPALELWKDIEDYDTADN-DLQPQ--KA-QTILA GPRK7_Hsap_GRK FHSLCEQQPIGRRLFRDFLATV-PTFRKAATFLEDVQNWELAEE-GPTKD--SALQGLVA GPRK6_Hsap_GRK YHSLCERQPIGRLLFREFCATR-PELSRCVAFLDGVAEYEVTPD-DKRKA--CG-RQLTQ GPRK5_Hsap_GRK YCSLCDKQPIGRLLFRQFCETR-PGLECYIQFLDSVAEYEVTPD-EKLGE--KG-KEIMT GPRK4_Hsap_GRK YSSLCDKQPIGRRLFRQFCDTK-PTLKRHIEFLDAVAEYEVADD-EDRSD--CG-LSILD Gprk1_Dmel_BARK FHKNF-NEVLGYLLFKDFCENDSEEPIQQLKFFEQIKLFEKTECYDERKK--MA-RDIYD Gprk2_Dmel_GRK YGYVIDQQPIGRELFRLFCENKRPVYFRYITFLDEVVKYEIEYI-SNRIF--IG-HDIGR GPRK6_Mmus_GRK YHSLCERQPIGRLLFREFCATR-PELTRCTAFLDGVSEYEVTPD-EKRKA--CG-RRLMQ GPRK5_Mmus_GRK YYSLCDKQPIGRLLFRQFCETR-PGLECYIQFLDLVAEYEITPD-ENLGA--KG-KEIMT GPRK4_Mmus_GRK FSSLCDKQPIGRLLFRQFCDTK-PDLKRCIEFLDAVAEYEVTIE-EEQRE--FG-LAIFS BARK2_Mmus_BARK FDKIF-NQKIGFLLFKDFCLNEIGEAVPQVKFYEEIKEYEKLDNEEDRLR--RS-RQMYD BARK1_Mmus_BARK FEKIF-SQKLGYLLFRDFCLNHLEEAKPLVEFYEEIKKYEKLETEEERVV--RS-REIFD F19C6.1_Cele_GRK YAFVVEKQPIGKLLFHEFCQATNSQYHQCCQFLTKVEEYETSDD-DGQSRRDLA-SSIVS BARK1_Hsap_BARK FEKIF-SQKLGYLLFRDFCLNHLEEARPLVEFYEEIKKYEKLETEEERVA--RS-REIFD BARK2_Hsap_BARK FDKIF-NQKIGFLLFKDFCLNEINEAVPQVKFYEEIKEYEKLDNEEDRLC--RS-RQIYD RHOK_Mmus_GRK FESLCSEQPIGKRLFQQFLKTD-ERHVPALELWKDIEDYDTADD-DLRPQ--KA-QAILA W02B3.2_Cele_BARK FDKIF-NQKLGFLLLKDYAENVSESPCPQIKFYEAIKEYEKMETPDERLT--KA-REIYD BARK_Spur_BARK FEKIF-GQKLGYLLFKDYCENCADVQVQQLQFYEAIKDYEKLDTLDERLE--EA-RRIFD GPRK_Spur_GRK ------------------------------------------------------------ AqueK007_Aque_BARK FHRIH-KQRMGTYFLEKFI----PPLCVTYSFLKAILDYEKTSSIVSRQK--KA-KQIYD AqueK008_Aque_GRK FEFIVEQQPIGHKLFLLFCEKD-LKLSRCMQFLHAVDELKIVVE-GKRLA--HA-QTVFD RHOK_Hsap_GRK QYLDP---------------------QAKL------------------------------ GPRK7_Hsap_GRK TCASA---------------------PAPG------------------------------ GPRK6_Hsap_GRK NFLSH---------------------TGPD------------------------------ GPRK5_Hsap_GRK KYLTP---------------------KSPV------------------------------ GPRK4_Hsap_GRK RFFND---------------------KLAA------------------------------ Gprk1_Dmel_BARK NFIME---------------------EMLS------------------------------ Gprk2_Dmel_GRK RFLDVEAQLELRNGSGGDALDAETQEELLLNSSNANPTETAETEHCNNTTANNCNNINNS GPRK6_Mmus_GRK NFLSH---------------------TGPD------------------------------ GPRK5_Mmus_GRK KYLTP---------------------KSPV------------------------------ GPRK4_Mmus_GRK RFFKE---------------------KSEV------------------------------ BARK2_Mmus_BARK AYIMR---------------------ELLS------------------------------ BARK1_Mmus_BARK SYIMK---------------------ELLA------------------------------ F19C6.1_Cele_GRK LLHSKPEDNPSGSQDEQEFWCSFLSDEVI------------------------------- BARK1_Hsap_BARK SYIMK---------------------ELLA------------------------------ BARK2_Hsap_BARK AYIMK---------------------ELLS------------------------------ RHOK_Mmus_GRK EYLDP---------------------QGTL------------------------------ W02B3.2_Cele_BARK HHIMV---------------------EMLA------------------------------ BARK_Spur_BARK NYIMK---------------------EVLS------------------------------ GPRK_Spur_GRK ------------------------------------------------------------ AqueK007_Aque_BARK KYIYA---------------------DMLA------------------------------ AqueK008_Aque_GRK DFLSL---------------------DSPQDQA--------------------------- RHOK_Hsap_GRK ------------------------------------------------------------ GPRK7_Hsap_GRK ------------------------------------------------------------ GPRK6_Hsap_GRK ------------------------------------------------------------ GPRK5_Hsap_GRK ------------------------------------------------------------ GPRK4_Hsap_GRK ------------------------------------------------------------ Gprk1_Dmel_BARK ------------------------------------------------------------ Gprk2_Dmel_GRK NNSQHSSDINHKKLDTRNHNGDDATGNGSSHQDDGDESVKCQEGHDDAEKGGGGEGGGGG GPRK6_Mmus_GRK ------------------------------------------------------------ GPRK5_Mmus_GRK ------------------------------------------------------------ GPRK4_Mmus_GRK ------------------------------------------------------------ BARK2_Mmus_BARK ------------------------------------------------------------ BARK1_Mmus_BARK ------------------------------------------------------------ F19C6.1_Cele_GRK ------------------------------------------------------------ BARK1_Hsap_BARK ------------------------------------------------------------ BARK2_Hsap_BARK ------------------------------------------------------------ RHOK_Mmus_GRK ------------------------------------------------------------ W02B3.2_Cele_BARK ------------------------------------------------------------ BARK_Spur_BARK ------------------------------------------------------------ GPRK_Spur_GRK ------------------------------------------------------------ AqueK007_Aque_BARK ------------------------------------------------------------ AqueK008_Aque_GRK ------------------------------------------------------------ RHOK_Hsap_GRK ------------F-------C-SFLDEGIVAKFKEGPV--EIQDGLFQPLLQATLAHLGQ GPRK7_Hsap_GRK ------------N-------PQPFLSQAVATKCQAATTE-EERVAAVTLAKAEAMAFLQE GPRK6_Hsap_GRK ------------L-------I-PEVPRQLVTNCTQRLEQ-GPCKDLFQELTRLTHEYLSV GPRK5_Hsap_GRK ------------F-------I-AQVGQDLVSQTEEKLLQ-KPCKELFSACAQSVHEYLRG GPRK4_Hsap_GRK ------------P-------L-PEIPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRG Gprk1_Dmel_BARK ------------H-------T-YEYSKHAVASVQKYLLKNEVPVDLFEPYLEEIFTQLKG Gprk2_Dmel_GRK KCVPVGGYPDELV-------L-DVLNDDLIAQVRNKL--NSGGKDIFAQCVNAVKAFLAG GPRK6_Mmus_GRK ------------L-------I-PEVPRQLVSNCAQRLEQ-GPCKDLFQELTRLTHEYLST GPRK5_Mmus_GRK ------------F-------I-AQVGQDLVSQTEKKLLQ-SPCKELFSACAQSVHDYLKG GPRK4_Mmus_GRK ------------P-------L-PEIPPDIVKECKWNLKQNSPSQNVFEECAGIVCKYLSE BARK2_Mmus_BARK ------------S-------T-HQFSKQAVEHVQSHLSKKQVTATLFQPYIEEICESLRG BARK1_Mmus_BARK ------------C-------S-HPFSKNATEHVQGHLVKKQVPPDLFQPYIEEICQNLRG F19C6.1_Cele_GRK --------------------------STCITTADSATHDDEPRSDIFTEPYRLTCQYLTD BARK1_Hsap_BARK ------------C-------S-HPFSKSATEHVQGHLGKKQVPPDLFQPYIEEICQNLRG BARK2_Hsap_BARK ------------C-------S-HPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRG RHOK_Mmus_GRK ------------F-------C-NFLDQGMVTRVKEGPT--GSQDGLFQPLLQATMEHLSQ W02B3.2_Cele_BARK ------------H-------A-HNYSKESLQHVQYHLLKQNVPPDLFHRYVLEICDQLRG BARK_Spur_BARK ------------C-------T-HQFSKSAVENVRQRLTNQEAKPDLFSDYITEILNSLKG GPRK_Spur_GRK ------------------------------------------------------------ AqueK007_Aque_BARK ------------M-------S-SKIPKEITDKVTVSLKANEVSTKLYGEIKEYLYDELTG AqueK008_Aque_GRK ------------SKFLGAGKL-ECVSDELATKTQEKLKG-IVPVDVFEECRQAVRDFLSG RHOK_Hsap_GRK APFQEYLGSLYFLRFLQWKWLEAQ---PMGEDWFLDFRVLGKGGFGEVSACQMKATGKLY GPRK7_Hsap_GRK QPFKDFVTSAFYDKFLQWKLFEMQ---PVSDKYFTEFRVLGKGGFGEVCAVQVKNTGKMY GPRK6_Hsap_GRK APFADYLDSIYFNRFLQWKWLERQ---PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMY GPRK5_Hsap_GRK EPFHEYLDSMFFDRFLQWKWLERQ---PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMY GPRK4_Hsap_GRK EPFEEYQESSYFSQFLQWKWLERQ---PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMY Gprk1_Dmel_BARK KPFKKFLESDKFTRFCQWKNLELNI--QLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMY Gprk2_Dmel_GRK EPFREFESSMYFHRYLQWKWLEAQ---PITYKTFRMYRVLGKGGFGEVCACQVRATGKMY GPRK6_Mmus_GRK APFADYLDSIYFNRFLQWKWLERQ---PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMY GPRK5_Mmus_GRK DPFHEYLDSMYFDRFLQWKWLERQ---PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMY GPRK4_Mmus_GRK TPFEEYQESTYFNRFLQWKWLERR---PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMY BARK2_Mmus_BARK DIFQKFMESDKFTRFCQWKNVELNI--HLSMNDFSVHRIIGRGGFGEVYGCRKADTGKMY BARK1_Mmus_BARK DVFQKFIESDKFTRFCQWKNVELNI--HLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMY F19C6.1_Cele_GRK APFKEFAESMYFHRFLQWKWLEKR---PVDKHTFRLYRVLGKGGFGEVCACQVRASGKMY BARK1_Hsap_BARK DVFQKFIESDKFTRFCQWKNVELNI--HLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMY BARK2_Hsap_BARK DIFQKFMESDKFTRFCQWKNVELNI--HLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMY RHOK_Mmus_GRK APFQEYLESLYFLRFLQWKWLEAQ---PIGEDWFLDFRVLGKGGFGEVSACQMKATGKMY W02B3.2_Cele_BARK DIFQRFLESDKFTRFCQWKNLELNM--QLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMY BARK_Spur_BARK EIFQKFLESDKFTRFCQWKNVELNINGMLSMNDFSVHRIIGRGGFGEVYGCRKADTGKMY GPRK_Spur_GRK ------------------------------------------------------------ AqueK007_Aque_BARK LYMKDFIHSSHYVRYCQWKYIELSVPHTISLSDFNVHRIIGRGGFGEVFGCRKDDSGKMF AqueK008_Aque_GRK QPLIDFVESPFYWRFLQWKTLERM---IITKDHFRQYRVLGKGGFGLVFACQSKFTGKMY RHOK_Hsap_GRK ACKKLNKKRLKKRKGYQGAMVEKKILMKVH----SRFIVSLAYAFETKADLCLVMTIMNG GPRK7_Hsap_GRK ACKKLDKKRLKKKGGEKMALLEKEILEKVS----SPFIVSLAYAFESKTHLCLVMSLMNG GPRK6_Hsap_GRK ACKKLEKKRIKKRKGEAMALNEKQILEKVN----SRFVVSLAYAYETKDALCLVLTLMNG GPRK5_Hsap_GRK ACKRLEKKRIKKRKGESMALNEKQILEKVN----SQFVVNLAYAYETKDALCLVLTIMNG GPRK4_Hsap_GRK ACKKLQKKRIKKRKGEAMALNEKRILEKVQ----SRFVVSLAYAYETKDALCLVLTIMNG Gprk1_Dmel_BARK AMKCLDKKRIKMKQGEMLALNERNMLQAVSTGIDCPFIVCMTYAFHTPDKLCFILDLMNG Gprk2_Dmel_GRK ACKKLEKKRIKKRKGESMVLIEKQILQKIN----SPFVVNLAYAYETKDALCLVLTIMNG GPRK6_Mmus_GRK ACKKLEKKRIKKRKGEAMALNEKQILEKVN----SRFVVSLAYAYETKDALCLVLTLMNG GPRK5_Mmus_GRK ACKRLEKKRIKKRKGESMALNEKQILEKVN----SQFVVNLAYAYETKDALCLVLTIMNG GPRK4_Mmus_GRK ACKKLEKKRIKKRKGEAMALNEKRILEKLH----SRFVVSLAYTYETKDALCLVLTIMNG BARK2_Mmus_BARK AMKCLDKKRVKMKQGETLALNERIMLSLVSTG-DCPFIVCMTYAFHTPDKLCFILDLMNG BARK1_Mmus_BARK AMKCLDKKRIKMKQGETLALNERIMLSLVSTG-DCPFIVCMSYAFHTPDKLSFILDLMNG F19C6.1_Cele_GRK ALKKLEKKRVKKRHAETLSLNEKQILQRIN----SPFVVSLAYAYETKDALCLVLTLMNG BARK1_Hsap_BARK AMKCLDKKRIKMKQGETLALNERIMLSLVSTG-DCPFIVCMSYAFHTPDKLSFILDLMNG BARK2_Hsap_BARK AMKCLDKKRIKMKQGETLALNERIMLSLVSTG-DCPFIVCMTYAFHTPDKLCFILDLMNG RHOK_Mmus_GRK ACKKLNKKRLKKRKGYQGAIVEKRILTKVH----SRFIVSLAYAFETKTDLCLVMTIMNG W02B3.2_Cele_BARK AMKCLDKKRIKMKQGETLALNERIMLSLVSTGQDCPFIVCMTYAFQSPDKLCFILDLMNG BARK_Spur_BARK AMKCLDKKRIKMKSGETLALNERIMLSLVSET-DCPFIVCMTYAFQTPDKLCFILDLMNG GPRK_Spur_GRK --------------------------------------VSLAYAFEMKEALCLVLTIMNG AqueK007_Aque_BARK AMKLLDKKRIKVKRGELLALNERNMLAKVN----SPFVVNLYYAFQTPEKLCFILDLMNG AqueK008_Aque_GRK ALKKLEKKRVKKRKGEKLALNEKEVLEKVD----SRFVVTLAYAYQSKDSLCMVLTLMNG * : *::. *.::: :*** RHOK_Hsap_GRK GDIRYHIYNVNEENPGFPEPRALFYTAQIICGLEHLHQRRIVYRDLKPENVLLDNDGNVR GPRK7_Hsap_GRK GDLKFHIYNVG--TRGLDMSRVIFYSAQIACGMLHLHELGIVYRDMKPENVLLDDLGNCR GPRK6_Hsap_GRK GDLKFHIYHMG--QAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIR GPRK5_Hsap_GRK GDLKFHIYNMG--NPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIR GPRK4_Hsap_GRK GDLKFHIYNLG--NPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIR Gprk1_Dmel_BARK GDLHYHLSQHG----IFSEDEMKFYAAEVILGLEHMHKRCIVYRDLKPANILLDENGHIR Gprk2_Dmel_GRK GDLKFHIYNMG-GEPGFELERARFYAAEVACGLQHLHKQGIVYRDCKPENILLDDHGHVR GPRK6_Mmus_GRK GDLKFHIYHMG--QAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIR GPRK5_Mmus_GRK GDLKFHIYNMG--NPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIR GPRK4_Mmus_GRK GDLKYHIYNLG--DPGFEEPRAVFYAAELCCGLEDLQRKRIVYRDLKPENILLDDHGHIR BARK2_Mmus_BARK GDMHYHLSQHG----VFSEKEMRFYASEIILGLEHMHTCFVVYRDLKPANILLDEYGHVR BARK1_Mmus_BARK GDLHYHLSQHG----VFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVR F19C6.1_Cele_GRK GDLKFHLYNLM--PGGFDEKRVQFYAAEITLGLQHLHSERILYRDLKPENILLDDFGHVR BARK1_Hsap_BARK GDLHYHLSQHG----VFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVR BARK2_Hsap_BARK GDLHYHLSQHG----VFSEKEMRFYATEIILGLEHMHNRFVVYRDLKPANILLDEHGHAR RHOK_Mmus_GRK GDVRYHIYNVDEDNPGFSEPRAIYYTAQIISGLEHLHQRRIVYRDLKPENVLLDNDGNIR W02B3.2_Cele_BARK GDLHYHLSQHG----VFTEQEMIFYASEVILGLEHMHNRFVVYRDLKPANILLDENGHVR BARK_Spur_BARK GDLHYHLSQHG----VFSEEEVGFYAAEIILGLEHMHVRNVVYRDLKPANILLDENGHVR GPRK_Spur_GRK GDLKFHIHNMG--SPGFEEERARFYAAEILCGLEDLHRLRIVYRDMKPENILLDDHGHVR AqueK007_Aque_BARK GDLHYHLTQHG----VFNEAEVRFYAAELILALEHIHSQLIVYRDLKPSNVLLDEAGHIR AqueK008_Aque_GRK GDLRFHIYSIG--SPGLEPERVVFYAAEIACGLHHLHTARIAYRDMKPDNILLDDAGHIR **:::*: : :*:::: .: .:: *** ** *:***: *: * RHOK_Hsap_GRK ISDLGLAVELLDGQSKTKGYAGTPGFMAPELLQ--------------------------- GPRK7_Hsap_GRK LSDLGLAVEMKGGK-PITQRAGTNGYMAPEILME-------------------------- GPRK6_Hsap_GRK ISDLGLAVHVPEGQ-TIKGRVGTVGYMAPEVVK--------------------------- GPRK5_Hsap_GRK ISDLGLAVKIPEGD-LIRGRVGTVGYMAPEVLN--------------------------- GPRK4_Hsap_GRK ISDLGLATEIPEGQ-RVRGRVGTVGYMAPEVVN--------------------------- Gprk1_Dmel_BARK ISDLGLACDFSKKK--PHASVGTHGYMAPEVLSK-------------------------- Gprk2_Dmel_GRK ISDLGLAVEIPEGE-MVRGRVGTVGYMAPEVID--------------------------- GPRK6_Mmus_GRK ISDLGLAVHVPEGQ-TIKGRVGTVGYMAPEVVR--------------------------- GPRK5_Mmus_GRK ISDLGLAVKIPEGD-LIRGRVGTVGYMAPEVLN--------------------------- GPRK4_Mmus_GRK ISDLGLAMEVPEGE-MVRGRVGTVGYMAPEIIN--------------------------- BARK2_Mmus_BARK ISDLGLACDFSKKK--PHASVGTHGYMAPEVLQK-------------------------- BARK1_Mmus_BARK ISDLGLACDFSKKR--PHASVGTHGYMAPEVLQK-------------------------- F19C6.1_Cele_GRK ISDLGLAVEIKDNE-PIKGRVGTVGYMAPEIVK--------------------------- BARK1_Hsap_BARK ISDLGLACDFSKKK--PHASVGTHGYMAPEVLQK-------------------------- BARK2_Hsap_BARK ISDLGLACDFSKKK--PHASVGTHGYMAPEVLQK-------------------------- RHOK_Mmus_GRK ISDLGLAVELKEGQNKTKGYAGTPGFMAPELLR--------------------------- W02B3.2_Cele_BARK VSDLGLACDYSKKK--PHASVGTHGYMAPEVLAK-------------------------- BARK_Spur_BARK ISDLGLACDFSSKK--PHASVGTHGYMAPEVLSKGTAYDSSADWFSLGCMLFKLLHGGTH GPRK_Spur_GRK ISDLGLAVEIPEND-TIRGRVGTVGYMAPEVVK--------------------------- AqueK007_Aque_BARK LSDLGLACEFSDRK--PSSCVGTHGYMAPEVIQK-------------------------- AqueK008_Aque_GRK ISDLGLAVHIPEGQ-SVRGRVGTPGYMAPEVID--------------------------- :****** . .** *:****:: RHOK_Hsap_GRK ----------GEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKHRIISEPVKY GPRK7_Hsap_GRK ----------KVSYSYPVDWFAMGCSIYEMVAGRTPFKDYKEKVSKEDLKQRTLQDEVKF GPRK6_Hsap_GRK ----------NERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEY GPRK5_Hsap_GRK ----------NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVY GPRK4_Hsap_GRK ----------NEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEY Gprk1_Dmel_BARK ----------GTSYDSCADWFSFGCMLYKLLKGHSPFRQHKTKDK-LEIDKMTLTMNVEL Gprk2_Dmel_GRK ----------NEKYAFSPDWFSFGCLLYEMIEGQAPFRMRKEKVKREEVDRRVKEDPEKY GPRK6_Mmus_GRK ----------NERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVAEEY GPRK5_Mmus_GRK ----------NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVY GPRK4_Mmus_GRK ----------HEKYTFSPDWWGLGCLIYEMIAGHSPFRKYKEKVNREELERRVKNETEEY BARK2_Mmus_BARK ----------GTCYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLTVNVQL BARK1_Mmus_BARK ----------GVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLTMAVEL F19C6.1_Cele_GRK ----------NERYSYGVDWWGVGCLIYEMIEGKAPFRQRKEKVKREEVERRVREDQEKY BARK1_Hsap_BARK ----------GVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLTMAVEL BARK2_Hsap_BARK ----------GTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLTVNVEL RHOK_Mmus_GRK ----------GEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKQRIISEPVKY W02B3.2_Cele_BARK ----------GVAYDSSADWFSLGCMLYKLLKGHSPFRQHKSKDK-NEIDKMTLTQDIEL BARK_Spur_BARK GYMAPEVLSKGTAYDSSADWFSLGCMLFKLLHGHSPFRQHKTKDK-HEIDRMTLTMDVEF GPRK_Spur_GRK ----------NERYTFSPDYWGLGCLIYEMIEGRAPFRARKEKVKREEVDRRVKEDDEKY AqueK007_Aque_BARK ----------GVHYDKSADWFSLGCVLYKLLRGHSPFRSQ---NK-DEVDQITLTKEVTM AqueK008_Aque_GRK ----------GHRYTFAPDWWGMGCLIYEMICGRTPFRKHKERVSREDIERRIKDDRVCL * *::..* ::::: .: **: . ::.: RHOK_Hsap_GRK P-DKFSQASKDFCEALLEKDPEKRLGFRD-----ETCDKLRAHPLFKD---------LNW GPRK7_Hsap_GRK QHDNFTEEAKDICRLFLAKKPEQRLGSRE-----K-SDDPRKHHFFKT---------INF GPRK6_Hsap_GRK S-ERFSPQARSLCSQLLCKDPAERLGCRG-----GSAREVKEHPLFKK---------LNF GPRK5_Hsap_GRK S-HKFSEEAKSICKMLLTKDAKQRLGCQE-----EGAAEVKRHPFFRN---------MNF GPRK4_Hsap_GRK S-EKFSEDAKSICRMLLTKNPSKRLGCRG-----EGAAGVKQHPVFKD---------INF Gprk1_Dmel_BARK -PESFSLELKNLLEMLLQRDVSKRLGCMG-----NGADEVKMHNFFCG---------IDW Gprk2_Dmel_GRK S-SKFNDEAKSMCQQLLAKSIKQRLGCRNGR---MGGQDVMAHPFFHST-------QLNW GPRK6_Mmus_GRK T-DRFSSQARSLCSQLLSKDPAERLGCRG-----GGAREVKEHPLFKK---------LNF GPRK5_Mmus_GRK S-SKFSEEAKSICNMLLTKDSKQRLGCQE-----EGAAEVKRHPFFRN---------MNF GPRK4_Mmus_GRK S-ERFSEDAKSICSMLLIKDPSKRLGCQR-----DGVSAVKQHPIFKD---------INF BARK2_Mmus_BARK -PDAFSPELRSLLEGLLQRDVSQRLGCGG-----GGARELKEHIFFKG---------IDW BARK1_Mmus_BARK -PDSFSPELRSLLEGLLQRDVNRRLGCLG-----RGAQEVKESPFFRS---------LDW F19C6.1_Cele_GRK S-EKFSEAARTLCRGLLHKEPGFRLGCRRVGRPEDGAEEIRAHPFFNTADTVTGREPVPW BARK1_Hsap_BARK -PDSFSPELRSLLEGLLQRDVNRRLGCLG-----RGAQEVKESPFFRS---------LDW BARK2_Hsap_BARK -PDTFSPELKSLLEGLLQRDVSKRLGCHG-----GGSQEVKEHSFFKG---------VDW RHOK_Mmus_GRK P-EKFSQASKDFCEQLLEKDPEKRLGFRD-----GTCDALRANVLFKD---------ISW W02B3.2_Cele_BARK PNEGLSKDCRDLLEGLLKRDVPDRLGCRG-----KGPTEVKEHPFFKD---------VDW BARK_Spur_BARK -PDKMSDEMRALLAGLLQREVASRLGCEG-----RGATEVREHPFFKT---------TDW GPRK_Spur_GRK S-QKFSTEAQDICKKLLQKDPALRMGFEN-----GTAQTVKDHSFFNS---------ISF AqueK007_Aque_BARK -PSSFSPGVSQLLTGLLEKDPTKRLGCLD-----TGVDAIKELPFFSD---------LNW AqueK008_Aque_GRK DNSAFTEDSRSICDQFLDKVHATRLGCCG-----EMFEDVKAHPFFQT---------IDF :. : :* : *:* .* : RHOK_Hsap_GRK RQLEAGMLMPPFIPDSKTVYAKDIQDVGAFS--TVKGVAFDKTDTEFFQEFATGNCPIPW GPRK7_Hsap_GRK PRLEAGLIEPPFVPDPSVVYAKDIAEIDDFS--EVRGVEFDDKDKQFFKNFATGAVPIAW GPRK6_Hsap_GRK KRLGAGMLEPPFKPDPQAIYCKDVLDIEQFS--TVKGVELEPTDQDFYQKFATGSVPIPW GPRK5_Hsap_GRK KRLEAGMLDPPFVPDPRAVYCKDVLDIEQFS--TVKGVNLDHTDDDFYSKFSTGSVSIPW GPRK4_Hsap_GRK RRLEANMLEPPFCPDPHAVYCKDVLDIEQFS--VVKGIYLDTADEDFYARFATGCVSIPW Gprk1_Dmel_BARK HQVYIQKYTPPLVPPRGEVNAADAFDIGSFDEEDTKGIKLNDADQDLYKMFSL-TISERW Gprk2_Dmel_GRK RRLEAGMLEPPFVPDPHAVYAKDVLDIEQFS--TVKGVNIDESDTNFYTKFNTGSVSISW GPRK6_Mmus_GRK KRLGAGMLEPPFKPDPQAIYCKDVLDIEQFS--TVKGVDLEPTDQDFYQKFATGSVSIPW GPRK5_Mmus_GRK KRLEAGMLDPPFVPDPRAVYCKDVLDIEQFS--TVKGVNLDHTDDDFYSKFSTGSVPIPW GPRK4_Mmus_GRK SRLEANMLDPPFIPDPQAIYCRNILDIGQFS--VVKGVNLDTNDEIFYAEFATGSVTIPW BARK2_Mmus_BARK QHVYLRKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDCDQDLYKNFPL-VISERW BARK1_Mmus_BARK QMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPL-TISERW F19C6.1_Cele_GRK KKMEAGKVTPPFCPDPRAVYAKDVLDIEQFS--TVKGVRLDATDTQFYGKFNTGCVSIPW BARK1_Hsap_BARK QMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPL-TISERW BARK2_Hsap_BARK QHVYLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDCDQELYKNFPL-VISERW RHOK_Mmus_GRK RQLEAGMLIPPFIPDSRTVYAKNIQDVGAFS--TVKGVVFDKADTEFFQEFASGNCSIPW W02B3.2_Cele_BARK QTVYLRRMTPPLIPPRGEVNAADAFDIGNFDDDEVKGVKLQDGDSDLYKNFNI-VISERW BARK_Spur_BARK NQVYYQKVQPPLIPPRGEVNAADAFDIGSFDEDDVKGIKVRNLPFLTF------------ GPRK_Spur_GRK SRLEAGKLDPPFEPDKRAVYAKDVLDIEQFS--TVKGVNLDQNDDRFYTKFNSGSVAIPW AqueK007_Aque_BARK DDVMEKKYAPPLIPPRGEVNAADAFDIGSFDSDETRGVKLNDEDQKMYSRFNV-VVSDRW AqueK008_Aque_GRK AHLEAGLIPPPFIPNSRAVYAKDVLDIDQFS--SVRGVEIEKADEDFADKFATGIVPKPW : **: * : . : :: *. .:*: . RHOK_Hsap_GRK QEEMIETGIFGELNVWRS-DGQMPDDMKG------------------------------- GPRK7_Hsap_GRK QEEIIETGLFEELNDPNR----------P------------------------------- GPRK6_Hsap_GRK QNEMVETECFQELNVFGL-DGSVPPDLDWK------------------------------ GPRK5_Hsap_GRK QNEMIETECFKELNVFGP-NGTLPPDLNR------------------------------- GPRK4_Hsap_GRK QNEMIESGCFKDINKSES-EEALPLDLDKN------------------------------ Gprk1_Dmel_BARK QQEVSET-VFDTVNTETDK-LEQKRKLKQKQHF---DAD--EKESDCILHGYIKKLGG-S Gprk2_Dmel_GRK QNEMMETECFRELNVFGP-EECPTPDLQIN------------------------------ GPRK6_Mmus_GRK QNEMVETECFQELNVFGL-DGSVPPDLDWK------------------------------ GPRK5_Mmus_GRK QNEMIETECFKELNVFGP-NGTLSPDLNR------------------------------- GPRK4_Mmus_GRK QNEMIESGCFKDLNENED-DLSSLEKY-KM------------------------------ BARK2_Mmus_BARK QQEVVET-IYDAVNADTDK-IEARRKAKNKQL---GQEEDYAMGKDCIMHGYMLKLGN-P BARK1_Mmus_BARK QQEVAET-VFDTINAETDR-LEARKKAKNKQL---GHEEDYALGKDCIVHGYMSKMGN-P F19C6.1_Cele_GRK QSEMIETECFAELNTFHDEDGNVMWNLRPD------------------------------ BARK1_Hsap_BARK QQEVAET-VFDTINAETDR-LEARKKAKNKQL---GHEEDYALGKDCIMHGYMSKMGN-P BARK2_Hsap_BARK QQEVTET-VYEAVNADTDK-IEARKRAKNKQL---GHEEDYALGKDCIMHGYMLKLGN-P RHOK_Mmus_GRK QEEMIETGLFGDLNVWRA-DGQMPDDMKG------------------------------- W02B3.2_Cele_BARK QNEIAET-IFEVVNQDADK-AESKKRSKQKIKV--AVEE---KDSDVIVHGYIKKLGG-P BARK_Spur_BARK ------------------------------------------------------------ GPRK_Spur_GRK QMEMIETQVFLELNVFGP-NGTLTADLMPD------------------------------ AqueK007_Aque_BARK QAEMMES-VFDSVNQDKEK-QEGKERSKSKNGILPFYTADGSFTDDSLLQGYGSKQSTAA AqueK008_Aque_GRK QEEVSS------------------------------------------------------ RHOK_Hsap_GRK -------------------ISG-------------------------------------- GPRK7_Hsap_GRK -------------------TGC-------------------------------------- GPRK6_Hsap_GRK --------------------GQP-PAPPK------------------------------- GPRK5_Hsap_GRK --------------------NHP-PEPPK------------------------------- GPRK4_Hsap_GRK -------------------IHTP-VSRPN------------------------------- Gprk1_Dmel_BARK FASLWQTKYAKLYPNRLELHSESGNNKPELIFM---DQVEDISSDFILHKNENCIQIRIN Gprk2_Dmel_GRK ---------------------AA-PEPDK------------------------------- GPRK6_Mmus_GRK --------------------GQP-TAPPK------------------------------- GPRK5_Mmus_GRK --------------------SQP-PEPPK------------------------------- GPRK4_Mmus_GRK --------------------CSS-ILRPK------------------------------- BARK2_Mmus_BARK FLTQWQRRYFYLFPNRLEWRGEG-ESRQSLLTM---EQIMSV--EETQIKDRKCILLRIK BARK1_Mmus_BARK FLTQWQRRYFYLFPNRLEWRGEG-EAPQSLLTM---EEIQSV--EETQIKERKCLLLKIR F19C6.1_Cele_GRK ---------------GINMDERR-NGTSK------------------------------- BARK1_Hsap_BARK FLTQWQRRYFYLFPNRLEWRGEG-EAPQSLLTM---EEIQSV--EETQIKERKCLLLKIR BARK2_Hsap_BARK FLTQWQRRYFYLFPNRLEWRGEG-ESRQNLLTM---EQILSV--EETQIKDKKCILFRIK RHOK_Mmus_GRK -------------------ITT-------------------------------------- W02B3.2_Cele_BARK FTSAWQTKYGKLYPSRLELYPESLTAKPELVFM---DQIEDVCAEMQTIKGETAIIVKLR BARK_Spur_BARK ------------------------------------------------------------ GPRK_Spur_GRK ---------------------LP-PPPPK------------------------------- AqueK007_Aque_BARK MFTHWQRKYFKLYPNRLDIGDSFTSMSKGLVSISFTESSILV--ESKQIKGTDIIRLQPI AqueK008_Aque_GRK ------------------------------------------------------------ RHOK_Hsap_GRK ------------------------------------------------------------ GPRK7_Hsap_GRK ------------------------------------------------------------ GPRK6_Hsap_GRK -------------------------------------------------------KGLLQ GPRK5_Hsap_GRK -------------------------------------------------------KGLLQ GPRK4_Hsap_GRK -------------------------------------------------------RGFFY Gprk1_Dmel_BARK DGTRDGRIILTNS-----------------------DEIGLKEWSSSLRSAHKISQDLLG Gprk2_Dmel_GRK -------------------------------------------------------AGCFP GPRK6_Mmus_GRK -------------------------------------------------------KGLLQ GPRK5_Mmus_GRK -------------------------------------------------------KGLFH GPRK4_Mmus_GRK -------------------------------------------------------RNFFR BARK2_Mmus_BARK GGKQ---FVLQCE-----------------------SDPEFAQWLKELTCTFNEAQRLLR BARK1_Mmus_BARK GGKQ---FVLQCD-----------------------SDPELVQWKKELRDAYREAQQLVQ F19C6.1_Cele_GRK -------------------------------------------------------PGFFS BARK1_Hsap_BARK GGKQ---FILQCD-----------------------SDPELVQWKKELRDAYREAQQLVQ BARK2_Hsap_BARK GGKQ---FVLQCE-----------------------SDPEFVQWKKELNETFKEAQRLLR RHOK_Mmus_GRK ------------------------------------------------------------ W02B3.2_Cele_BARK DGFK---EPKICLTNSVSENVLKYKTEKKNCRSVYLDEISLKEWHTSLRTAHKVSQELLQ BARK_Spur_BARK ------------------------------------------------------------ GPRK_Spur_GRK -------------------------------------------------------QGFFR AqueK007_Aque_BARK GTRR--ETCIKFE-----------------------SQLEHQMWFRFLRDAIHKHD---- AqueK008_Aque_GRK ------------------------------------------------------------ RHOK_Hsap_GRK ----------------------------------------------------G--SSSSS GPRK7_Hsap_GRK ----------------------------------------------------E--EGNSS GPRK6_Hsap_GRK RLFSRQRIAVETA------------ATA---R----------KS-SP--P---A-SSPQP GPRK5_Hsap_GRK RLFKRQHQNNSKS------------SPS---S----------KT-SFNHH---I-NSNHV GPRK4_Hsap_GRK RLFRRGGCLTM--------------V-------------------------------PSE Gprk1_Dmel_BARK SMAKKAGKIYGSE-----------R-----------------DV-NKS---MYIFGGNCS Gprk2_Dmel_GRK --FRRKK-----------------KQPA---R----------TQPIPIPE-HLL-TTSHS GPRK6_Mmus_GRK RLFSRQRIAVGTA------------ATV---R----------KS-SP--P---A-SSPQA GPRK5_Mmus_GRK RLFRRQHQSNSKS------------SPT---P----------KT-SCNHR---I-NSNHI GPRK4_Mmus_GRK RLFRRTGCLNI----------------------------------------------ALS BARK2_Mmus_BARK RAPK--------------------------FL----------NK-PRAAI-LEFSKPPLC BARK1_Mmus_BARK RVPK--------------------------MK----------NK-PRSPV-VELSKVPLI F19C6.1_Cele_GRK RLFRKKNIEVTKSLHDLSHLGVEQQQPP---K----------TS-TQTPA-VRS-SRAAS BARK1_Hsap_BARK RVPK--------------------------MK----------NK-PRSPV-VELSKVPLV BARK2_Hsap_BARK RAPK--------------------------FL----------NK-PRSGT-VELPKPSLC RHOK_Mmus_GRK ----------------------------------------------------EE-AAPTA W02B3.2_Cele_BARK RMGRKAIKIYGVN-----------HDPM--LS----------ES-ERPGS-VTRAFLNRA BARK_Spur_BARK ------------------------------------------------------------ GPRK_Spur_GRK RIFRIKDIKEKDG-----------KNKS---T----------KG-LQSEKIFEY-RKSKE AqueK007_Aque_BARK -----------ST-----------KDPSGPIALEDGGLIQRRQI-SDSPA-R--RARELG AqueK008_Aque_GRK ------------------------------------------------------------ RHOK_Hsap_GRK KSGMCLVS GPRK7_Hsap_GRK KSGVCLLL GPRK6_Hsap_GRK EAPTSSWR GPRK5_Hsap_GRK SSNSTGSS GPRK4_Hsap_GRK KEVEPKQC Gprk1_Dmel_BARK TKTSNGSN Gprk2_Dmel_GRK VSSTTVES GPRK6_Mmus_GRK EAPTGGWR GPRK5_Mmus_GRK NSNSTGSS GPRK4_Mmus_GRK EEREPTEH BARK2_Mmus_BARK H-RNSSGL BARK1_Mmus_BARK QRGSANGL F19C6.1_Cele_GRK ASGRTLVI BARK1_Hsap_BARK QRGSANGL BARK2_Hsap_BARK H-RNSNGL RHOK_Mmus_GRK KSGMCLIS W02B3.2_Cele_BARK -SSVDSGV BARK_Spur_BARK ---LNLKT GPRK_Spur_GRK IYGVHNTP AqueK007_Aque_BARK YTRSVPIL AqueK008_Aque_GRK -------T