CLUSTAL W (1.83) multiple sequence alignment GSK3B_Hsap MSGRPRTT---------------------------------------------------- GSK3A_Hsap MSGGGPSGGGP----------------G-------------------------------- Pk34A_Dmel MENKEKKQKPLK------------------------------------------------ sgg_Dmel MFTFYTNINNTLINNNNNNNNTSNSNNNNNNVISQPIKIPLTERFSSQTSTGSADSGVIV gskt_Dmel MASQSKNSG--------------------------------------------------- GSK3B_Mmus MSGRPRTT---------------------------------------------------- GSK3A_Mmus MSGGGPSGGGP----------------G-------------------------------- R03D7.5_Cele MANFIRLAYN-------------------------------------------------- F21F3.2_Cele MSVTVEQ----------------------------------------------------- C44H4.6_Cele MNRMRRSTAFS------------------------------------------------- C36B1.10_Cele MPNTYRTSDE-------------------------------------------------- RIM11_Scer MNIQSNNSPNLS------------------------------------------------ MRK1_Scer MTDVLRSLVRKI------------------------------------------------ MCK1_Scer MSTEEQNG--V------------------------------------------------- Y106G6D.4_Cele MNEDENKGIV-------------------------------------------------- Y106G6E.1_Cele MPNIYRTTDE-------------------------------------------------- Y18D10A.5_Cele MNKQLLSC---------------------------------------------------- YOL128C_Scer MLKVNNVFGSN------------------------------------------------- GlkA_Ddis MTIPTDNNSSNN------------------------------------------------ GSK-3_Ddis MSSKDQILE-K------------------------------------------------- 19912_Tthe MLSQTVPLSSVL------------------------------------------------ 19923_Tthe MGGNGSRMH--------------------------------------------------- 19924_Tthe MNMRIPTQNYD------------------------------------------------- 2636_Tthe MIKREILIKSKI------------------------------------------------ 5825_Tthe MNVSQSQGNVMQ------------------------------------------------ 7876_Tthe MYNNMTSNKPN------------------------------------------------- GSK3_Spur MCTVERPASGEW---------------S-------------------------------- n1163_Tthe MAEFQQETEQLK------------------------------------------------ CC1G_03802_Ccin MATHGPING--------------------------------------------------- AqueK117_Aque MSSTFNKKEPP------------------------------------------------- GSK_b_Smoe MESRVDSMQ-E------------------------------------------------- GSK_a-2_Smoe MASASVGPVGA------------------------------------------------- GSK_a-1_Smoe MASASVGPVGA------------------------------------------------- GK035_Glam MLPQKLPEL--------------------------------------------------- GK036_Glam MSDDETAFPPE------------------------------------------------- * GSK3B_Hsap ------------------------------------------------------------ GSK3A_Hsap ----------GSGRARTS------------------------------------------ Pk34A_Dmel ------------------------------------------------------------ sgg_Dmel SSASQQQLQLPPPRSSSG------------------------------------------ gskt_Dmel ------------------------------------------------------------ GSK3B_Mmus ------------------------------------------------------------ GSK3A_Mmus ----------GSGRARTS------------------------------------------ R03D7.5_Cele ------------------------------------------------------------ F21F3.2_Cele ------------------------------------------------------------ C44H4.6_Cele ------------------------------------------------------------ C36B1.10_Cele ------------------------------------------------------------ RIM11_Scer ------------------------------------------------------------ MRK1_Scer -------------SFNNS------------------------------------------ MCK1_Scer ------------------------------------------------------------ Y106G6D.4_Cele ------------------------------------------------------------ Y106G6E.1_Cele ------------------------------------------------------------ Y18D10A.5_Cele ------------------------------------------------------------ YOL128C_Scer ------------------------------------------------------------ GlkA_Ddis ------------------------------------------------------------ GSK-3_Ddis ------------------------------------------------------------ 19912_Tthe ------------------------------------------------------------ 19923_Tthe ------------------------------------------------------------ 19924_Tthe ------------------------------------------------------------ 2636_Tthe ------------------------------------------------------------ 5825_Tthe ----------------S------------------------------------------- 7876_Tthe ------------------------------------------------------------ GSK3_Spur ----------THRRPVSS------------------------------------------ n1163_Tthe ----------------QLLQATYQGTSTEQVKHAEKELQNVSHHQDFLKYLVYIMKDTAN CC1G_03802_Ccin ------------------------------------------------------------ AqueK117_Aque -------------RIRTT------------------------------------------ GSK_b_Smoe ------------------------------------------------------------ GSK_a-2_Smoe ------------IRGSTS------------------------------------------ GSK_a-1_Smoe ------------IRGSTS------------------------------------------ GK035_Glam ------------------------------------------------------------ GK036_Glam ------------------------------------------------------------ GSK3B_Hsap --------------------------------S---F-AES----C-------------- GSK3A_Hsap --------------------------------S---F-AEP----G-------------- Pk34A_Dmel --------------------------------R---H----------------------- sgg_Dmel --------------------------------S---L-SLP----Q-------------- gskt_Dmel ------------------------------------L----------------------- GSK3B_Mmus --------------------------------S---F-AES----C-------------- GSK3A_Mmus --------------------------------S---F-AEP----G-------------- R03D7.5_Cele ------------------------------------------------------------ F21F3.2_Cele ------------------------------------------------------------ C44H4.6_Cele ------------------------------------------------------------ C36B1.10_Cele ------------------------------------------------------------ RIM11_Scer --------------------------------N---N--------I-------------- MRK1_Scer --------------------------------D---NLQLKHKTSI-------------- MCK1_Scer ------------------------------------P----------------------- Y106G6D.4_Cele ------------------------------------------------------------ Y106G6E.1_Cele ------------------------------------------------------------ Y18D10A.5_Cele --------------------------------S---L----------------------- YOL128C_Scer ------------------------------------P----------------------- GlkA_Ddis --------------------------------KGYND--------NNNNNNNNNNNNNNN GSK-3_Ddis ------------------------------------------------------------ 19912_Tthe --------------------------------E---VLPQQRVNA--------------- 19923_Tthe ------------------------------------------------------------ 19924_Tthe --------------------------------K---E--------V-------------- 2636_Tthe --------------------------------S--KN--------S-------------- 5825_Tthe --------------------------------Q---N--------L-------------- 7876_Tthe --------------------------------N---R--------L-------------- GSK3_Spur --------------------------------A---Y-SKI----V-------------- n1163_Tthe PLLMQKSASNYVHVYVRNIYSKTSQSGQIQQIQ---E--------I-------------- CC1G_03802_Ccin ------------------------------------V----------------------- AqueK117_Aque --------------------------------S---F-ADP----M-------------- GSK_b_Smoe ------------------------------------------------------------ GSK_a-2_Smoe --------------------------------A---I-VVS------------------- GSK_a-1_Smoe --------------------------------A---I-VVS------------------- GK035_Glam ------------------------------------------------------------ GK036_Glam ------------------------------------------------------------ GSK3B_Hsap -K---------------------------------------------------------- GSK3A_Hsap -G---------------GGGGGGGGPGGSASGP----GGTGGGKASVGAMGGGVGASSSG Pk34A_Dmel ------------------------------------------------------------ sgg_Dmel -APPGGKWRQKQQRQQLLLSQDSGIENGVTTRPSKAKDNQGAGKASHNATS--SKESGAQ gskt_Dmel ------------------------------------------------------------ GSK3B_Mmus -K---------------------------------------------------------- GSK3A_Mmus -G---------------GGGGGGGGPGGSASGP----GGTGGGKASVGAMGGGVGASSSG R03D7.5_Cele ------------------------------------------------------------ F21F3.2_Cele ------------------------------------------------------------ C44H4.6_Cele ------------------------------------------------------------ C36B1.10_Cele ------------------------------------------------------------ RIM11_Scer ------------------------------------------------------------ MRK1_Scer ------------------------------------------------------------ MCK1_Scer ------------------------------------------------------------ Y106G6D.4_Cele ------------------------------------------------------------ Y106G6E.1_Cele ------------------------------------------------------------ Y18D10A.5_Cele ------------------------------------------------------------ YOL128C_Scer ------------------------------------------------------------ GlkA_Ddis NN---------------------------------------------------------- GSK-3_Ddis ------------------------------------------------------------ 19912_Tthe ------------------------------------------------------------ 19923_Tthe ------------------------------------------------------------ 19924_Tthe ------------------------------------------------------------ 2636_Tthe -I---------------------------------------------------------- 5825_Tthe ------------------------------------------------------------ 7876_Tthe ------------------------------------------------------------ GSK3_Spur -M---------------------------------------------------------- n1163_Tthe ------------------------------------------------------------ CC1G_03802_Ccin ------------------------------------------------------------ AqueK117_Aque -G---------------------------------------------------------- GSK_b_Smoe ------------------------------------------------------------ GSK_a-2_Smoe ------------------------------------------------------------ GSK_a-1_Smoe ------------------------------------------------------------ GK035_Glam ------------------------------------------------------------ GK036_Glam ------------------------------------------------------------ GSK3B_Hsap ---------------------------------------------P-V------------ GSK3A_Hsap G--------------------------------GPGGSGGGGSGGP-G------------ Pk34A_Dmel ------------------------------------------------------------ sgg_Dmel SNSSSESLGSNCSEAQEQQRVRASSALELSSVDTPVIVGGVVSGGN-SILRSRIKYKSTN gskt_Dmel ------------------------------------------------------------ GSK3B_Mmus ---------------------------------------------P-V------------ GSK3A_Mmus G--------------------------------GPSGSGGGGSGGP-G------------ R03D7.5_Cele ------------------------------------------------------------ F21F3.2_Cele ------------------------------------------------------------ C44H4.6_Cele ------------------------------------------------------------ C36B1.10_Cele ------------------------------------------------------------ RIM11_Scer ------------------------------------------------------------ MRK1_Scer ------------------------------------------------------------ MCK1_Scer ------------------------------------------------------------ Y106G6D.4_Cele ------------------------------------------------------------ Y106G6E.1_Cele ------------------------------------------------------------ Y18D10A.5_Cele ------------------------------------------------------------ YOL128C_Scer ------------------------------------------------------------ GlkA_Ddis ------------------------------------------------------------ GSK-3_Ddis ------------------------------------------------------------ 19912_Tthe -----------------------------------------------L------------ 19923_Tthe ------------------------------------------------------------ 19924_Tthe ------------------------------------------------------------ 2636_Tthe ------------------------------------------------------------ 5825_Tthe ------------------------------------------------------------ 7876_Tthe ------------------------------------------------------------ GSK3_Spur ---------------------------------------------PRI------------ n1163_Tthe ------------------------------------------------------------ CC1G_03802_Ccin ------------------------------------------------------------ AqueK117_Aque ----------------------------------------------RE------------ GSK_b_Smoe ------------------------------------------------------------ GSK_a-2_Smoe ----------------------------------------------KV------------ GSK_a-1_Smoe ----------------------------------------------KV------------ GK035_Glam ------------------------------------------------------------ GK036_Glam ------------------------------------------------------------ GSK3B_Hsap ---------------------------------------------------------Q-- GSK3A_Hsap ------------------------------------------------------------ Pk34A_Dmel ------------------------------------------------------------ sgg_Dmel STGTQGFDVEDRIDEVDICDDDDVDCDDRGSEIEEEEEDQTEQEEEVDEVDAKPKNRL-- gskt_Dmel ------------------------------------------------------------ GSK3B_Mmus ---------------------------------------------------------Q-- GSK3A_Mmus ------------------------------------------------------------ R03D7.5_Cele ------------------------------------------------------------ F21F3.2_Cele ------------------------------------------------------------ C44H4.6_Cele ------------------------------------------------------------ C36B1.10_Cele ------------------------------------------------------------ RIM11_Scer ------------------------------------------------------------ MRK1_Scer ---------------------------------------------------------Q-- MCK1_Scer ------------------------------------------------------------ Y106G6D.4_Cele ------------------------------------------------------------ Y106G6E.1_Cele ------------------------------------------------------------ Y18D10A.5_Cele ------------------------------------------------------------ YOL128C_Scer ------------------------------------------------------------ GlkA_Ddis ---------------------------------------------------------NNN GSK-3_Ddis ------------------------------------------------------------ 19912_Tthe ---------------------------------------------------------Q-- 19923_Tthe ------------------------------------------------------------ 19924_Tthe ---------------------------------------------------------L-- 2636_Tthe ---------------------------------------------------------PKA 5825_Tthe ---------------------------------------------------------Q-- 7876_Tthe ---------------------------------------------------------N-- GSK3_Spur ---------------------------------------------------------S-- n1163_Tthe ---------------------------------------------------------T-- CC1G_03802_Ccin ------------------------------------------------------------ AqueK117_Aque ---------------------------------------------------------T-- GSK_b_Smoe ------------------------------------------------------------ GSK_a-2_Smoe ---------------------------------------------------------G-- GSK_a-1_Smoe ---------------------------------------------------------G-- GK035_Glam ------------------------------------------------------------ GK036_Glam ------------------------------------------------------------ GSK3B_Hsap -QP--S------------------------------------------------------ GSK3A_Hsap -AG--T------------------------------------------------------ Pk34A_Dmel ------------------------------------------------------------ sgg_Dmel -LP--PDQAELTVAAAMARRRDAKSLATDGHIYFPLLKISEDPHIDSKLINRKDGLQDTM gskt_Dmel ------------------------------------------------------------ GSK3B_Mmus -QP--S------------------------------------------------------ GSK3A_Mmus -AG--T------------------------------------------------------ R03D7.5_Cele ------------------------------------------------------------ F21F3.2_Cele ------------------------------------------------------------ C44H4.6_Cele ------------------------------------------------------------ C36B1.10_Cele ------------------------------------------------------------ RIM11_Scer ------------------------------------------------------------ MRK1_Scer -SN--T------------------------------------------------------ MCK1_Scer ------------------------------------------------------------ Y106G6D.4_Cele ------------------------------------------------------------ Y106G6E.1_Cele ------------------------------------------------------------ Y18D10A.5_Cele ------------------------------------------------------------ YOL128C_Scer ------------------------------------------------------------ GlkA_Ddis N----------------------------------------------------------- GSK-3_Ddis ------------------------------------------------------------ 19912_Tthe -Q---Y------------------------------------------------------ 19923_Tthe ------------------------------------------------------------ 19924_Tthe ------------------------------------------------------------ 2636_Tthe FF---------------------------------------------------------- 5825_Tthe ------------------------------------------------------------ 7876_Tthe ------------------------------------------------------------ GSK3_Spur -ST--K------------------------------------------------------ n1163_Tthe ------------------------------------------------------------ CC1G_03802_Ccin ------------------------------------------------------------ AqueK117_Aque ------------------------------------------------------------ GSK_b_Smoe ------------------------------------------------------------ GSK_a-2_Smoe -GSGVD------------------------------------------------------ GSK_a-1_Smoe -GSGVD------------------------------------------------------ GK035_Glam ------------------------------------------------------------ GK036_Glam ------------------------------------------------------------ GSK3B_Hsap ----------------------------A------------------------------- GSK3A_Hsap ----------------------------S------------------------------- Pk34A_Dmel ------------------------------------------------------------ sgg_Dmel YYLDEFGSPKLREKFARKQKQLLAKQQKQLMKRERRSEEQRKKRNTTVASNLAASGAVVD gskt_Dmel ------------------------------------------------------------ GSK3B_Mmus ----------------------------A------------------------------- GSK3A_Mmus ----------------------------S------------------------------- R03D7.5_Cele ------------------------------------------------------------ F21F3.2_Cele ------------------------------------------------------------ C44H4.6_Cele ------------------------------------------------------------ C36B1.10_Cele ------------------------------------------------------------ RIM11_Scer ------------------------------------------------------------ MRK1_Scer ----------------------------A------------------------------- MCK1_Scer ------------------------------------------------------------ Y106G6D.4_Cele ------------------------------------------------------------ Y106G6E.1_Cele ------------------------------------------------------------ Y18D10A.5_Cele ------------------------------------------------------------ YOL128C_Scer ------------------------------------------------------------ GlkA_Ddis ------------------------------------------------------------ GSK-3_Ddis ------------------------------------------------------------ 19912_Tthe ----------------------------A------------------------------- 19923_Tthe ------------------------------------------------------------ 19924_Tthe ------------------------------------------------------------ 2636_Tthe ------------------------------------------------------------ 5825_Tthe ------------------------------------------------------------ 7876_Tthe ------------------------------------------------------------ GSK3_Spur ----------------------------I------------------------------- n1163_Tthe ------------------------------------------------------------ CC1G_03802_Ccin ------------------------------------------------------------ AqueK117_Aque ------------------------------------------------------------ GSK_b_Smoe ------------------------------------------------------------ GSK_a-2_Smoe ----------------------------Q------------------------------- GSK_a-1_Smoe ----------------------------Q------------------------------- GK035_Glam ------------------------------------------------------------ GK036_Glam ------------------------------------------------------------ GSK3B_Hsap ------------------------F---------G------------------------- GSK3A_Hsap ------------------------F---------P------------------------- Pk34A_Dmel -----------------------------------A------------------------ sgg_Dmel DTKDDYKQQPHCDTSSRSKNNSVPN---------P--P---------------------- gskt_Dmel ------------------------------------------------------------ GSK3B_Mmus ------------------------F---------G------------------------- GSK3A_Mmus ------------------------F---------P------------------------- R03D7.5_Cele ------------------------------------------------------------ F21F3.2_Cele ------------------------------------------------------------ C44H4.6_Cele ------------------------------------------------------------ C36B1.10_Cele ------------------------------------------------------------ RIM11_Scer ------------------------------------------------------------ MRK1_Scer ------------------------LEK---KKRKPDTIKKVSDVQVHHTVPNFNNSSEYI MCK1_Scer ------------------------------------------------------------ Y106G6D.4_Cele ------------------------------------------------------------ Y106G6E.1_Cele ------------------------------------------------------------ Y18D10A.5_Cele ------------------------------------------------------------ YOL128C_Scer -----------------------------------N------------------------ GlkA_Ddis ------------------------------NNKEHPN----------------------- GSK-3_Ddis ------------------------------------------------------------ 19912_Tthe ------------------------FGESPQKTKRSN---KTQD-----RVSLFNGS---- 19923_Tthe ------------------------------------------------------------ 19924_Tthe ----------------------------------PT------------------------ 2636_Tthe ------------------------FFFFFFKQFQQKN----------------------- 5825_Tthe ----------------------------------QQ------------------------ 7876_Tthe -----------------------------------D------------------------ GSK3_Spur ------------------------L---------PPSS---------------------- n1163_Tthe ----------------------------------EQ------------------------ CC1G_03802_Ccin ------------------------------------------------------------ AqueK117_Aque ------------------------R---------PPQV---------------------- GSK_b_Smoe ------------------------------------------------------------ GSK_a-2_Smoe ------------------------L---------PEEM---------------------- GSK_a-1_Smoe ------------------------L---------PEEM---------------------- GK035_Glam ------------------------------------------------------------ GK036_Glam ------------------------------------------------------------ GSK3B_Hsap ------------------------------------------------------------ GSK3A_Hsap ------------------------------------------------------------ Pk34A_Dmel ------------------------------------------------------------ sgg_Dmel ------------------------------------------------------------ gskt_Dmel ------------------------------------------------------------ GSK3B_Mmus ------------------------------------------------------------ GSK3A_Mmus ------------------------------------------------------------ R03D7.5_Cele ------------------------------------------------------------ F21F3.2_Cele ------------------------------------------------------------ C44H4.6_Cele ------------------------------------------------------------ C36B1.10_Cele ------------------------------------------------------------ RIM11_Scer ------------------------------------------------------------ MRK1_Scer NDIENLIISKL------------------------------------------------- MCK1_Scer ------------------------------------------------------------ Y106G6D.4_Cele ------------------------------------------------------------ Y106G6E.1_Cele ------------------------------------------------------------ Y18D10A.5_Cele ------------------------------------------------------------ YOL128C_Scer ------------------------------------------------------------ GlkA_Ddis ------------------------------------------------------------ GSK-3_Ddis ------------------------------------------------------------ 19912_Tthe ---ASIMMTTI------------------------------------------------- 19923_Tthe ------------------------------------------------------------ 19924_Tthe ----------Q------------------------------------------------- 2636_Tthe ------------------------------------------------------------ 5825_Tthe ------------------------------------------------------------ 7876_Tthe ------------------------------------------------------------ GSK3_Spur ------------------------------------------------------------ n1163_Tthe ----------IILAMRDSNISIDCKHNISKGLSIILSLDRPQTWILQDDITQLASTLIIL CC1G_03802_Ccin ------------------------------------------------------------ AqueK117_Aque ------------------------------------------------------------ GSK_b_Smoe ------------------------------------------------------------ GSK_a-2_Smoe ------------------------------------------------------------ GSK_a-1_Smoe ------------------------------------------------------------ GK035_Glam ------------------------------------------------------------ GK036_Glam ------------------------------------------------------------ GSK3B_Hsap ------------------------------------------------------------ GSK3A_Hsap ------------------------------------------------------------ Pk34A_Dmel ------------------------------------------------------------ sgg_Dmel ------------------------------------------------------------ gskt_Dmel ------------------------------------------------------------ GSK3B_Mmus ------------------------------------------------------------ GSK3A_Mmus ------------------------------------------------------------ R03D7.5_Cele ------------------------------------------------------------ F21F3.2_Cele ------------------------------------------------------------ C44H4.6_Cele ------------------------------------------------------------ C36B1.10_Cele ------------------------------------------------------------ RIM11_Scer ------------------------------------------------------------ MRK1_Scer ------------------------------------------------------------ MCK1_Scer ------------------------------------------------------------ Y106G6D.4_Cele ------------------------------------------------------------ Y106G6E.1_Cele ------------------------------------------------------------ Y18D10A.5_Cele ------------------------------------------------------------ YOL128C_Scer ------------------------------------------------------------ GlkA_Ddis ------------------------------------------------------------ GSK-3_Ddis ------------------------------------------------------------ 19912_Tthe ------------------------------------------------------------ 19923_Tthe ------------------------------------------------------------ 19924_Tthe ------------------------------------------------------------ 2636_Tthe ------------------------------------------------------------ 5825_Tthe ------------------------------------------------------------ 7876_Tthe ------------------------------------------------------------ GSK3_Spur ------------------------------------------------------------ n1163_Tthe QTVIISTQQKEFLAHFFNLLNMPFCQVGSNYLTEITSSLQLLEKSQNEQETTQIFQKTVE CC1G_03802_Ccin ------------------------------------------------------------ AqueK117_Aque ------------------------------------------------------------ GSK_b_Smoe ------------------------------------------------------------ GSK_a-2_Smoe ------------------------------------------------------------ GSK_a-1_Smoe ------------------------------------------------------------ GK035_Glam ------------------------------------------------------------ GK036_Glam ------------------------------------------------------------ GSK3B_Hsap ------------------------------------------------------------ GSK3A_Hsap ------------------------------------------------------------ Pk34A_Dmel ------------------------------------------------------------ sgg_Dmel ------------------------------------------------------------ gskt_Dmel ------------------------------------------------------------ GSK3B_Mmus ------------------------------------------------------------ GSK3A_Mmus ------------------------------------------------------------ R03D7.5_Cele ------------------------------------------------------------ F21F3.2_Cele ------------------------------------------------------------ C44H4.6_Cele ------------------------------------------------------------ C36B1.10_Cele ------------------------------------------------------------ RIM11_Scer ------------------------------------------------------------ MRK1_Scer ------------------------------------------------------------ MCK1_Scer ------------------------------------------------------------ Y106G6D.4_Cele ------------------------------------------------------------ Y106G6E.1_Cele ------------------------------------------------------------ Y18D10A.5_Cele ------------------------------------------------------------ YOL128C_Scer ------------------------------------------------------------ GlkA_Ddis ------------------------------------------------------------ GSK-3_Ddis ------------------------------------------------------------ 19912_Tthe ------------------------------------------------------------ 19923_Tthe ------------------------------------------------------------ 19924_Tthe ------------------------------------------------------------ 2636_Tthe ------------------------------------------------------------ 5825_Tthe ------------------------------------------------------------ 7876_Tthe ------------------------------------------------------------ GSK3_Spur ------------------------------------------------------------ n1163_Tthe GIKVLNLWAIVLKDLIIQVMESKNRKLISFVLENEILANLICHGICVTLNTPLQIKDCLI CC1G_03802_Ccin ------------------------------------------------------------ AqueK117_Aque ------------------------------------------------------------ GSK_b_Smoe ------------------------------------------------------------ GSK_a-2_Smoe ------------------------------------------------------------ GSK_a-1_Smoe ------------------------------------------------------------ GK035_Glam ------------------------------------------------------------ GK036_Glam ------------------------------------------------------------ GSK3B_Hsap ------------------------------------------------------------ GSK3A_Hsap ------------------------------------------------------------ Pk34A_Dmel ------------------------------------------------------------ sgg_Dmel ------------------------------------------------------------ gskt_Dmel ------------------------------------------------------------ GSK3B_Mmus ------------------------------------------------------------ GSK3A_Mmus ------------------------------------------------------------ R03D7.5_Cele ------------------------------------------------------------ F21F3.2_Cele ------------------------------------------------------------ C44H4.6_Cele ------------------------------------------------------------ C36B1.10_Cele ------------------------------------------------------------ RIM11_Scer ------------------------------------------------------------ MRK1_Scer ------------------------------------------------------------ MCK1_Scer ------------------------------------------------------------ Y106G6D.4_Cele ------------------------------------------------------------ Y106G6E.1_Cele ------------------------------------------------------------ Y18D10A.5_Cele ------------------------------------------------------------ YOL128C_Scer ------------------------------------------------------------ GlkA_Ddis ------------------------------------------------------------ GSK-3_Ddis ------------------------------------------------------------ 19912_Tthe ------------------------------------------------------------ 19923_Tthe ------------------------------------------------------------ 19924_Tthe ------------------------------------------------------------ 2636_Tthe ------------------------------------------------------------ 5825_Tthe ------------------------------------------------------------ 7876_Tthe ------------------------------------------------------------ GSK3_Spur ------------------------------------------------------------ n1163_Tthe CTSGQSDFDDAANTLKSHLIKAYTRINRQMFAERSKFDIFKTQFFKLLQQSLPIILKGLM CC1G_03802_Ccin ------------------------------------------------------------ AqueK117_Aque ------------------------------------------------------------ GSK_b_Smoe ------------------------------------------------------------ GSK_a-2_Smoe ------------------------------------------------------------ GSK_a-1_Smoe ------------------------------------------------------------ GK035_Glam ------------------------------------------------------------ GK036_Glam ------------------------------------------------------------ GSK3B_Hsap ------------------------------------------------------------ GSK3A_Hsap ------------------------------------------------------------ Pk34A_Dmel ------------------------------------------------------------ sgg_Dmel ------------------------------------------------------------ gskt_Dmel ------------------------------------------------------------ GSK3B_Mmus ------------------------------------------------------------ GSK3A_Mmus ------------------------------------------------------------ R03D7.5_Cele ------------------------------------------------------------ F21F3.2_Cele ------------------------------------------------------------ C44H4.6_Cele ------------------------------------------------------------ C36B1.10_Cele ------------------------------------------------------------ RIM11_Scer ------------------------------------------------------------ MRK1_Scer ------------------------------------------------------------ MCK1_Scer ------------------------------------------------------------ Y106G6D.4_Cele ------------------------------------------------------------ Y106G6E.1_Cele ------------------------------------------------------------ Y18D10A.5_Cele ------------------------------------------------------------ YOL128C_Scer ------------------------------------------------------------ GlkA_Ddis ------------------------------------------------------------ GSK-3_Ddis ------------------------------------------------------------ 19912_Tthe ------------------------------------------------------------ 19923_Tthe ------------------------------------------------------------ 19924_Tthe ------------------------------------------------------------ 2636_Tthe ------------------------------------------------------------ 5825_Tthe ------------------------------------------------------------ 7876_Tthe ------------------------------------------------------------ GSK3_Spur ------------------------------------------------------------ n1163_Tthe LFCQQTPDFQDKLENKSLSSIVIECLKFSHICAEQSEFYKIFQDCSRVLLLEVIFPLMRS CC1G_03802_Ccin ------------------------------------------------------------ AqueK117_Aque ------------------------------------------------------------ GSK_b_Smoe ------------------------------------------------------------ GSK_a-2_Smoe ------------------------------------------------------------ GSK_a-1_Smoe ------------------------------------------------------------ GK035_Glam ------------------------------------------------------------ GK036_Glam ------------------------------------------------------------ GSK3B_Hsap ------------------------------------------------------------ GSK3A_Hsap ------------------------------------------------------------ Pk34A_Dmel ------------------------------------------------------------ sgg_Dmel ------------------------------------------------------------ gskt_Dmel ------------------------------------------------------------ GSK3B_Mmus ------------------------------------------------------------ GSK3A_Mmus ------------------------------------------------------------ R03D7.5_Cele ------------------------------------------------------------ F21F3.2_Cele ------------------------------------------------------------ C44H4.6_Cele ------------------------------------------------------------ C36B1.10_Cele ------------------------------------------------------------ RIM11_Scer ------------------------------------------------------------ MRK1_Scer ------------------------------------------------------------ MCK1_Scer ------------------------------------------------------------ Y106G6D.4_Cele ------------------------------------------------------------ Y106G6E.1_Cele ------------------------------------------------------------ Y18D10A.5_Cele ------------------------------------------------------------ YOL128C_Scer ------------------------------------------------------------ GlkA_Ddis ------------------------------------------------------------ GSK-3_Ddis ------------------------------------------------------------ 19912_Tthe ------------------------------------------------------------ 19923_Tthe ------------------------------------------------------------ 19924_Tthe ------------------------------------------------------------ 2636_Tthe ------------------------------------------------------------ 5825_Tthe ------------------------------------------------------------ 7876_Tthe ------------------------------------------------------------ GSK3_Spur ------------------------------------------------------------ n1163_Tthe SQSEQESLENNPEEFVRLALDTCDRQISYSYKCAAAKLLETVCDYIDGFETIVSLLLIQI CC1G_03802_Ccin ------------------------------------------------------------ AqueK117_Aque ------------------------------------------------------------ GSK_b_Smoe ------------------------------------------------------------ GSK_a-2_Smoe ------------------------------------------------------------ GSK_a-1_Smoe ------------------------------------------------------------ GK035_Glam ------------------------------------------------------------ GK036_Glam ------------------------------------------------------------ GSK3B_Hsap ------------------------------------------------------------ GSK3A_Hsap ------------------------------------------------------------ Pk34A_Dmel ------------------------------------------------------------ sgg_Dmel ------------------------------------------------------------ gskt_Dmel ------------------------------------------------------------ GSK3B_Mmus ------------------------------------------------------------ GSK3A_Mmus ------------------------------------------------------------ R03D7.5_Cele ------------------------------------------------------------ F21F3.2_Cele ------------------------------------------------------------ C44H4.6_Cele ------------------------------------------------------------ C36B1.10_Cele ------------------------------------------------------------ RIM11_Scer ------------------------------------------------------------ MRK1_Scer ------------------------------------------------------------ MCK1_Scer ------------------------------------------------------------ Y106G6D.4_Cele ------------------------------------------------------------ Y106G6E.1_Cele ------------------------------------------------------------ Y18D10A.5_Cele ------------------------------------------------------------ YOL128C_Scer ------------------------------------------------------------ GlkA_Ddis ------------------------------------------------------------ GSK-3_Ddis ------------------------------------------------------------ 19912_Tthe ------------------------------------------------------------ 19923_Tthe ------------------------------------------------------------ 19924_Tthe ------------------------------------------------------------ 2636_Tthe ------------------------------------------------------------ 5825_Tthe ------------------------------------------------------------ 7876_Tthe ------------------------------------------------------------ GSK3_Spur ------------------------------------------------------------ n1163_Tthe VGFSIKFENITDVDANYPNLIPFKETVFMSKTERHIRIETCFVALSVLSYLTPKRPDIVG CC1G_03802_Ccin ------------------------------------------------------------ AqueK117_Aque ------------------------------------------------------------ GSK_b_Smoe ------------------------------------------------------------ GSK_a-2_Smoe ------------------------------------------------------------ GSK_a-1_Smoe ------------------------------------------------------------ GK035_Glam ------------------------------------------------------------ GK036_Glam ------------------------------------------------------------ GSK3B_Hsap ------------------------------------------------------------ GSK3A_Hsap ------------------------------------------------------------ Pk34A_Dmel ------------------------------------------------------------ sgg_Dmel ------------------------------------------------------------ gskt_Dmel ------------------------------------------------------------ GSK3B_Mmus ------------------------------------------------------------ GSK3A_Mmus ------------------------------------------------------------ R03D7.5_Cele ------------------------------------------------------------ F21F3.2_Cele ------------------------------------------------------------ C44H4.6_Cele ------------------------------------------------------------ C36B1.10_Cele ------------------------------------------------------------ RIM11_Scer ------------------------------------------------------------ MRK1_Scer ------------------------------------------------------------ MCK1_Scer ------------------------------------------------------------ Y106G6D.4_Cele ------------------------------------------------------------ Y106G6E.1_Cele ------------------------------------------------------------ Y18D10A.5_Cele ------------------------------------------------------------ YOL128C_Scer ------------------------------------------------------------ GlkA_Ddis ------------------------------------------------------------ GSK-3_Ddis ------------------------------------------------------------ 19912_Tthe ------------------------------------------------------------ 19923_Tthe ------------------------------------------------------------ 19924_Tthe ------------------------------------------------------------ 2636_Tthe ------------------------------------------------------------ 5825_Tthe ------------------------------------------------------------ 7876_Tthe ------------------------------------------------------------ GSK3_Spur ------------------------------------------------------------ n1163_Tthe QIELLLKEHAQFLFNHNIHRLIKVRVCLMLGYYTDSVFQNEKENYKSLIQFLLSCLTLKE CC1G_03802_Ccin ------------------------------------------------------------ AqueK117_Aque ------------------------------------------------------------ GSK_b_Smoe ------------------------------------------------------------ GSK_a-2_Smoe ------------------------------------------------------------ GSK_a-1_Smoe ------------------------------------------------------------ GK035_Glam ------------------------------------------------------------ GK036_Glam ------------------------------------------------------------ GSK3B_Hsap ------------------------------------------------------------ GSK3A_Hsap ------------------------------------------------------------ Pk34A_Dmel ------------------------------------------------------------ sgg_Dmel ------------------------------------------------------------ gskt_Dmel ------------------------------------------------------------ GSK3B_Mmus ------------------------------------------------------------ GSK3A_Mmus ------------------------------------------------------------ R03D7.5_Cele ------------------------------------------------------------ F21F3.2_Cele ------------------------------------------------------------ C44H4.6_Cele ------------------------------------------------------------ C36B1.10_Cele ------------------------------------------------------------ RIM11_Scer ------------------------------------------------------------ MRK1_Scer -IDGG------------------------------------------------------- MCK1_Scer ------------------------------------------------------------ Y106G6D.4_Cele ------------------------------------------------------------ Y106G6E.1_Cele ------------------------------------------------------------ Y18D10A.5_Cele ------------------------------------------------------------ YOL128C_Scer ------------------------------------------------------------ GlkA_Ddis ------------------------------------------------------------ GSK-3_Ddis ------------------------------------------------------------ 19912_Tthe -Q---------------------------------------------------------- 19923_Tthe ------------------------------------------------------------ 19924_Tthe -ADEG------------------------------------------------------- 2636_Tthe ------------------------------------------------------------ 5825_Tthe ------------------------------------------------------------ 7876_Tthe ------------------------------------------------------------ GSK3_Spur ------------------------------------------------------------ n1163_Tthe QEDQGIVYQAIDSLQNIYDDDNQVNLVSENINEVLHVILPLITTTEFHQFMDIVFHIFRY CC1G_03802_Ccin ------------------------------------------------------------ AqueK117_Aque ------------------------------------------------------------ GSK_b_Smoe ------------------------------------------------------------ GSK_a-2_Smoe ------------------------------------------------------------ GSK_a-1_Smoe ------------------------------------------------------------ GK035_Glam ------------------------------------------------------------ GK036_Glam ------------------------------------------------------------ GSK3B_Hsap ------------------------------------------------------------ GSK3A_Hsap ------------------------------------------------------------ Pk34A_Dmel ------------------------------------------------------------ sgg_Dmel ------------------------------------------------------------ gskt_Dmel ------------------------------------------------------------ GSK3B_Mmus ------------------------------------------------------------ GSK3A_Mmus ------------------------------------------------------------ R03D7.5_Cele ------------------------------------------------------------ F21F3.2_Cele ------------------------------------------------------------ C44H4.6_Cele ------------------------------------------------------------ C36B1.10_Cele ------------------------------------------------------------ RIM11_Scer ------------------------------------------------------------ MRK1_Scer ------------------------------------------------------------ MCK1_Scer ------------------------------------------------------------ Y106G6D.4_Cele ------------------------------------------------------------ Y106G6E.1_Cele ------------------------------------------------------------ Y18D10A.5_Cele ------------------------------------------------------------ YOL128C_Scer ------------------------------------------------------------ GlkA_Ddis ------------------------------------------------------------ GSK-3_Ddis ------------------------------------------------------------ 19912_Tthe ------------------------------------------------------------ 19923_Tthe ------------------------------------------------------------ 19924_Tthe ------------------------------------------------------------ 2636_Tthe ------------------------------------------------------------ 5825_Tthe ------------------------------------------------------------ 7876_Tthe ------------------------------------------------------------ GSK3_Spur ------------------------------------------------------------ n1163_Tthe HSKNIAPQNIINCVGYLVKRIIDEVKLIDDKLRNDQIYINKCWNIIRDMSDNKFIVPQYI CC1G_03802_Ccin ------------------------------------------------------------ AqueK117_Aque ------------------------------------------------------------ GSK_b_Smoe ------------------------------------------------------------ GSK_a-2_Smoe ------------------------------------------------------------ GSK_a-1_Smoe ------------------------------------------------------------ GK035_Glam ------------------------------------------------------------ GK036_Glam ------------------------------------------------------------ GSK3B_Hsap ------------------------------------------------------------ GSK3A_Hsap ------------------------------------------------------------ Pk34A_Dmel ------------------------------------------------------------ sgg_Dmel ------------------------------------------------------------ gskt_Dmel ------------------------------------------------------------ GSK3B_Mmus ------------------------------------------------------------ GSK3A_Mmus ------------------------------------------------------------ R03D7.5_Cele ------------------------------------------------------------ F21F3.2_Cele ------------------------------------------------------------ C44H4.6_Cele ------------------------------------------------------------ C36B1.10_Cele ------------------------------------------------------------ RIM11_Scer ------------------------------------------------------------ MRK1_Scer ------------------------------------------------------------ MCK1_Scer ------------------------------------------------------------ Y106G6D.4_Cele ------------------------------------------------------------ Y106G6E.1_Cele ------------------------------------------------------------ Y18D10A.5_Cele ------------------------------------------------------------ YOL128C_Scer ------------------------------------------------------------ GlkA_Ddis ------------------------------------------------------------ GSK-3_Ddis ------------------------------------------------------------ 19912_Tthe ------------------------------------------------------------ 19923_Tthe ------------------------------------------------------------ 19924_Tthe ------------------------------------------------------------ 2636_Tthe ------------------------------------------------------------ 5825_Tthe ------------------------------------------------------------ 7876_Tthe ------------------------------------------------------------ GSK3_Spur ------------------------------------------------------------ n1163_Tthe NSILEQLRPLLQCVQYPEKIEFDEDIILLVGSFIYHQKAVNPICSDLITCFPLILKKQQG CC1G_03802_Ccin ------------------------------------------------------------ AqueK117_Aque ------------------------------------------------------------ GSK_b_Smoe ------------------------------------------------------------ GSK_a-2_Smoe ------------------------------------------------------------ GSK_a-1_Smoe ------------------------------------------------------------ GK035_Glam ------------------------------------------------------------ GK036_Glam ------------------------------------------------------------ GSK3B_Hsap ------------------------------------------------------------ GSK3A_Hsap ------------------------------------------------------------ Pk34A_Dmel ------------------------------------------------------------ sgg_Dmel ------------------------------------------------------------ gskt_Dmel ------------------------------------------------------------ GSK3B_Mmus ------------------------------------------------------------ GSK3A_Mmus ------------------------------------------------------------ R03D7.5_Cele ------------------------------------------------------------ F21F3.2_Cele ------------------------------------------------------------ C44H4.6_Cele ------------------------------------------------------------ C36B1.10_Cele ------------------------------------------------------------ RIM11_Scer ------------------------------------------------------------ MRK1_Scer ---------------------------------------------------KEGIAVD-- MCK1_Scer ------------------------------------------------------------ Y106G6D.4_Cele ------------------------------------------------------------ Y106G6E.1_Cele ------------------------------------------------------------ Y18D10A.5_Cele ------------------------------------------------------------ YOL128C_Scer ------------------------------------------------------------ GlkA_Ddis ------------------------------------------------------------ GSK-3_Ddis ------------------------------------------------------------ 19912_Tthe ------------------------------------------------------SKAD-- 19923_Tthe ------------------------------------------------------------ 19924_Tthe ---------------------------------------------------I-GSRVH-- 2636_Tthe ------------------------------------------------------------ 5825_Tthe ------------------------------------------------------------ 7876_Tthe ------------------------------------------------------------ GSK3_Spur ------------------------------------------------------------ n1163_Tthe VFAQLFKTLNNVIIYGQEFLIQNASHLQLIIKMAYDTMFSDSSKSTDSDKAE-GAAIMQL CC1G_03802_Ccin ------------------------------------------------------------ AqueK117_Aque ------------------------------------------------------------ GSK_b_Smoe ------------------------------------------------------------ GSK_a-2_Smoe ------------------------------------------------------------ GSK_a-1_Smoe ------------------------------------------------------------ GK035_Glam ------------------------------------------------------------ GK036_Glam ------------------------------------------------------------ GSK3B_Hsap ------------------------------------------------------------ GSK3A_Hsap ------------------------------------------------------------ Pk34A_Dmel ------------------------------------------------------------ sgg_Dmel ------------------------------------------------------------ gskt_Dmel ------------------------------------------------------------ GSK3B_Mmus ------------------------------------------------------------ GSK3A_Mmus ------------------------------------------------------------ R03D7.5_Cele ------------------------------------------------------------ F21F3.2_Cele ------------------------------------------------------------ C44H4.6_Cele ------------------------------------------------------------ C36B1.10_Cele ------------------------------------------------------------ RIM11_Scer ------------------------------------------------------------ MRK1_Scer ------------------------------------------------------------ MCK1_Scer ------------------------------------------------------------ Y106G6D.4_Cele ------------------------------------------------------------ Y106G6E.1_Cele ------------------------------------------------------------ Y18D10A.5_Cele ------------------------------------------------------------ YOL128C_Scer ------------------------------------------------------------ GlkA_Ddis ------------------------------------------------------------ GSK-3_Ddis ------------------------------------------------------------ 19912_Tthe ------------------------------------------------------------ 19923_Tthe ------------------------------------------------------------ 19924_Tthe ------------------------------------------------------------ 2636_Tthe ------------------------------------------------------------ 5825_Tthe ------------------------------------------------------------ 7876_Tthe ------------------------------------------------------------ GSK3_Spur ------------------------------------------------------------ n1163_Tthe IVQSLGNNLTDEMWKIIFNAAIQRFQSQTKLRHSFAYGRTAGIFLSGFNSNIQKSTQILT CC1G_03802_Ccin ------------------------------------------------------------ AqueK117_Aque ------------------------------------------------------------ GSK_b_Smoe ------------------------------------------------------------ GSK_a-2_Smoe ------------------------------------------------------------ GSK_a-1_Smoe ------------------------------------------------------------ GK035_Glam ------------------------------------------------------------ GK036_Glam ------------------------------------------------------------ GSK3B_Hsap ------------------------------------------------------------ GSK3A_Hsap ------------------------------------------------------------ Pk34A_Dmel ------------------------------------------------------------ sgg_Dmel ------------------------------------------------------------ gskt_Dmel ------------------------------------------------------------ GSK3B_Mmus ------------------------------------------------------------ GSK3A_Mmus ------------------------------------------------------------ R03D7.5_Cele ------------------------------------------------------------ F21F3.2_Cele ------------------------------------------------------------ C44H4.6_Cele ------------------------------------------------------------ C36B1.10_Cele ------------------------------------------------------------ RIM11_Scer ------------------------------------------------------------ MRK1_Scer ------------------------------------------------------------ MCK1_Scer ------------------------------------------------------------ Y106G6D.4_Cele ------------------------------------------------------------ Y106G6E.1_Cele ------------------------------------------------------------ Y18D10A.5_Cele ------------------------------------------------------------ YOL128C_Scer ------------------------------------------------------------ GlkA_Ddis ------------------------------------------------------------ GSK-3_Ddis ------------------------------------------------------------ 19912_Tthe ------------------------------------------------------------ 19923_Tthe ------------------------------------------------------------ 19924_Tthe ------------------------------------------------------------ 2636_Tthe ------------------------------------------------------------ 5825_Tthe ------------------------------------------------------------ 7876_Tthe ------------------------------------------------------------ GSK3_Spur ------------------------------------------------------------ n1163_Tthe EMGLLEQVIILCVSKLEMYKRNYDIKLFIMSMSKVIVQVSLDANKVLQIFDCLISLMMKQ CC1G_03802_Ccin ------------------------------------------------------------ AqueK117_Aque ------------------------------------------------------------ GSK_b_Smoe ------------------------------------------------------------ GSK_a-2_Smoe ------------------------------------------------------------ GSK_a-1_Smoe ------------------------------------------------------------ GK035_Glam ------------------------------------------------------------ GK036_Glam ------------------------------------------------------------ GSK3B_Hsap ------------------------------------------------------------ GSK3A_Hsap ------------------------------------------------------------ Pk34A_Dmel ------------------------------------------------------------ sgg_Dmel -------------SSHLHQNHNHLVVDVQEDVDDVNVVATSDVDSGVVKMRRHSHDNHYD gskt_Dmel ------------------------------------------------------------ GSK3B_Mmus ------------------------------------------------------------ GSK3A_Mmus ------------------------------------------------------------ R03D7.5_Cele ------------------------------------------------------------ F21F3.2_Cele ------------------------------------------------------------ C44H4.6_Cele ------------------------------------------------------------ C36B1.10_Cele ------------------------------------------------------------ RIM11_Scer ------------------------------------------------------------ MRK1_Scer -----------HIE---------------------------------------------- MCK1_Scer ------------------------------------------------------------ Y106G6D.4_Cele ------------------------------------------------------------ Y106G6E.1_Cele ------------------------------------------------------------ Y18D10A.5_Cele ------------------------------------------------------------ YOL128C_Scer ------------------------------------------------------------ GlkA_Ddis ------------IN---------------------------------------------- GSK-3_Ddis ------------------------------------------------------------ 19912_Tthe -----------TLP---------------------------------------------- 19923_Tthe -----------TVG---------------------------------------------- 19924_Tthe -----------TVG---------------------------------------------- 2636_Tthe ------------LQ---------------------------------------------- 5825_Tthe -----------QLA---------------------------------------------- 7876_Tthe -----------EIN---------------------------------------------- GSK3_Spur ------------------------------------------------------------ n1163_Tthe KELEQKLEKKRKLK---------------------------------------------- CC1G_03802_Ccin ------------------------------------------------------------ AqueK117_Aque ------------------------------------------------------------ GSK_b_Smoe ------------------------------------------------------------ GSK_a-2_Smoe -------------H---------------------------------------------- GSK_a-1_Smoe -------------H---------------------------------------------- GK035_Glam ------------------------------------------------------------ GK036_Glam ------------F----------------------------------------------- GSK3B_Hsap ------------------------------------------------------------ GSK3A_Hsap ------------------------------------------------------------ Pk34A_Dmel ------------------------------------------------------------ sgg_Dmel RIPRSNAATITTRPQIDQQSSHHQNTEDVEQGAEPQIDGEADLDADADADSDGSGENVKT gskt_Dmel ------------------------------------------------------------ GSK3B_Mmus ------------------------------------------------------------ GSK3A_Mmus ------------------------------------------------------------ R03D7.5_Cele ------------------------------------------------------------ F21F3.2_Cele ------------------------------------------------------------ C44H4.6_Cele ------------------------------------------------------------ C36B1.10_Cele ------------------------------------------------------------ RIM11_Scer ------------------------------------------------------------ MRK1_Scer ------------------------------------------------------------ MCK1_Scer ------------------------------------------------------------ Y106G6D.4_Cele ------------------------------------------------------------ Y106G6E.1_Cele ------------------------------------------------------------ Y18D10A.5_Cele ------------------------------------------------------------ YOL128C_Scer ------------------------------------------------------------ GlkA_Ddis ------------------------------------------------------------ GSK-3_Ddis ------------------------------------------------------------ 19912_Tthe --------------PID------------------------------------------- 19923_Tthe ------------------------------------------------------------ 19924_Tthe ------------------------------------------------------------ 2636_Tthe ------------------------------------------------------------ 5825_Tthe ------------------------------------------------------------ 7876_Tthe ------------------------------------------------------------ GSK3_Spur ------------------------------------------------------------ n1163_Tthe ------------------------------------------------------------ CC1G_03802_Ccin ------------------------------------------------------------ AqueK117_Aque ------------------------------------------------------------ GSK_b_Smoe ------------------------------------------------------------ GSK_a-2_Smoe ------------------------------------------------------------ GSK_a-1_Smoe ------------------------------------------------------------ GK035_Glam ------------------------------------------------------------ GK036_Glam ------------------------------------------------------------ GSK3B_Hsap -------S------------M------KVSRD---------------------------- GSK3A_Hsap -------P------------P------GVKLG---------------------------- Pk34A_Dmel ---------------------------QVPL----------------------------- sgg_Dmel AKLARTQS------------C------KNQTG---------------------------- gskt_Dmel ------------------------------------------------------------ GSK3B_Mmus -------S------------M------KVSRD---------------------------- GSK3A_Mmus -------P------------P------GVKLG---------------------------- R03D7.5_Cele ------------------------------------------------------------ F21F3.2_Cele ------------------------------------------------------------ C44H4.6_Cele ------------------------------------------------------------ C36B1.10_Cele ------------------------------------------------------------ RIM11_Scer ------------------------------------------------------------ MRK1_Scer -------H------------A------NISDS---------------------------- MCK1_Scer ----------------------------LQR----------------------------- Y106G6D.4_Cele ------------------------------------------------------------ Y106G6E.1_Cele ------------------------------------------------------------ Y18D10A.5_Cele ------------------------------------------------------------ YOL128C_Scer ---------------------------RMTKL---------------------------- GlkA_Ddis -------NNNNNNNNNNNNNI------KESSS---------------------------- GSK-3_Ddis ------------------------------------------------------------ 19912_Tthe ------QY------------SKYRQNTQASNS---------------------------- 19923_Tthe -------S------------M------KESDK---------------------------- 19924_Tthe -------S------------M------KENEY---------------------------- 2636_Tthe -------QFYKNQQQKNDTFI--------------------------------------- 5825_Tthe ----------------------------QQQQ---------------------------- 7876_Tthe ----------------------------QNHQ---------------------------- GSK3_Spur -------S------------S------KSIRD---------------------------- n1163_Tthe ----------------------------DDDNNNNSDDEGDDDDYDDDDDDDEDDDEEVD CC1G_03802_Ccin ---------------------------KISPI---------------------------- AqueK117_Aque ------GG------------M------RVTRD---------------------------- GSK_b_Smoe ------------------------------------------------------------ GSK_a-2_Smoe -------E------------M------KIRDD---------------------------- GSK_a-1_Smoe -------E------------M------KIRDD---------------------------- GK035_Glam ------------------------------------------------------------ GK036_Glam ------------------------------------------------------------ GSK3B_Hsap ------------------------------------------------------------ GSK3A_Hsap ------------------------------------------------------------ Pk34A_Dmel ------------------------------------------------------------ sgg_Dmel ------------------------------------------------------------ gskt_Dmel ------------------------------------------------------------ GSK3B_Mmus ------------------------------------------------------------ GSK3A_Mmus ------------------------------------------------------------ R03D7.5_Cele ------------------------------------------------------------ F21F3.2_Cele ------------------------------------------------------------ C44H4.6_Cele ------------------------------------------------------------ C36B1.10_Cele ------------------------------------------------------------ RIM11_Scer ------------------------------------------------------------ MRK1_Scer ------------------------------------------------------------ MCK1_Scer ------------------------------------------------------------ Y106G6D.4_Cele ------------------------------------------------------------ Y106G6E.1_Cele ------------------------------------------------------------ Y18D10A.5_Cele ------------------------------------------------------------ YOL128C_Scer ------------------------------------------------------------ GlkA_Ddis ------------------------------------------------------------ GSK-3_Ddis ------------------------------------------------------------ 19912_Tthe ------------------------------------------------------------ 19923_Tthe ------------------------------------------------------------ 19924_Tthe ------------------------------------------------------------ 2636_Tthe ------------------------------------------------------------ 5825_Tthe ------------------------------------------------------------ 7876_Tthe ------------------------------------------------------------ GSK3_Spur ------------------------------------------------------------ n1163_Tthe GDEDNDLNVNHYDKEYDCSVNADKLMLKEMVSPINDVDEFAIFKQSYSTMKSQNFTALQQ CC1G_03802_Ccin ------------------------------------------------------------ AqueK117_Aque ------------------------------------------------------------ GSK_b_Smoe ------------------------------------------------------------ GSK_a-2_Smoe ------------------------------------------------------------ GSK_a-1_Smoe ------------------------------------------------------------ GK035_Glam ------------------------------------------------------------ GK036_Glam ------------------------------------------------------------ GSK3B_Hsap ---------------------------------K-------------------------- GSK3A_Hsap ---------------------------------R-------------------------- Pk34A_Dmel ---------------------------------I-------------------------- sgg_Dmel ---------------------------------R-------------------------- gskt_Dmel ------------------------------------------------------------ GSK3B_Mmus ---------------------------------K-------------------------- GSK3A_Mmus ---------------------------------R-------------------------- R03D7.5_Cele ------------------------------------------------------------ F21F3.2_Cele ------------------------------------------------------------ C44H4.6_Cele ------------------------------------------------------------ C36B1.10_Cele ------------------------------------------------------------ RIM11_Scer ------------------------------------------------------------ MRK1_Scer ---------------------------------K-------------------------- MCK1_Scer ------------------------------------------------------------ Y106G6D.4_Cele ------------------------------------------------------------ Y106G6E.1_Cele ------------------------------------------------------------ Y18D10A.5_Cele ---------------------------------K-------------------------- YOL128C_Scer ---------------------------------E-------------------------- GlkA_Ddis ---------------------------------S-------------------------- GSK-3_Ddis ------------------------------------------------------------ 19912_Tthe ---------------------------------K-------------------------- 19923_Tthe ---------------------------------K-------------------------- 19924_Tthe ---------------------------------Q-------------------------- 2636_Tthe ---------------------------------L-------------------------- 5825_Tthe ---------------------------------A-------------------------- 7876_Tthe ---------------------------------K-------------------------- GSK3_Spur ---------------------------------K-------------------------- n1163_Tthe LVYGLNQEKQKYLAQLLSVQRVNVGSEQVIRLRGGGGECHLISFISILKNIIYIFRIQKR CC1G_03802_Ccin ---------------------------------D-------------------------- AqueK117_Aque ---------------------------------K-------------------------- GSK_b_Smoe ------------------------------------------------------------ GSK_a-2_Smoe ---------------------------------K-------------------------- GSK_a-1_Smoe ---------------------------------K-------------------------- GK035_Glam ------------------------------------------------------------ GK036_Glam ------------------------------------------------------------ GSK3B_Hsap ------------------------------------------------------------ GSK3A_Hsap ------------------------------------------------------------ Pk34A_Dmel ------------------------------------------------------------ sgg_Dmel ------------------------------------------------------------ gskt_Dmel ------------------------------------------------------------ GSK3B_Mmus ------------------------------------------------------------ GSK3A_Mmus ------------------------------------------------------------ R03D7.5_Cele ------------------------------------------------------------ F21F3.2_Cele ------------------------------------------------------------ C44H4.6_Cele ------------------------------------------------------------ C36B1.10_Cele ------------------------------------------------------------ RIM11_Scer ------------------------------------------------------------ MRK1_Scer ------------------------------------------------------------ MCK1_Scer ------------------------------------------------------------ Y106G6D.4_Cele ------------------------------------------------------------ Y106G6E.1_Cele ------------------------------------------------------------ Y18D10A.5_Cele ------------------------------------------------------------ YOL128C_Scer ------------------------------------------------------------ GlkA_Ddis ------------------------------------------------------------ GSK-3_Ddis ------------------------------------------------------------ 19912_Tthe ------------------------------------------------------------ 19923_Tthe ------------------------------------------------------------ 19924_Tthe ------------------------------------------------------------ 2636_Tthe ------------------------------------------------------------ 5825_Tthe ------------------------------------------------------------ 7876_Tthe ------------------------------------------------------------ GSK3_Spur ------------------------------------------------------------ n1163_Tthe IFADLSASALEIIFSSRQIENLIFEISHFFRKMKESFFTLKKFNFRKENENLRINRLVSY CC1G_03802_Ccin ------------------------------------------------------------ AqueK117_Aque ------------------------------------------------------------ GSK_b_Smoe ------------------------------------------------------------ GSK_a-2_Smoe ------------------------------------------------------------ GSK_a-1_Smoe ------------------------------------------------------------ GK035_Glam ------------------------------------------------------------ GK036_Glam ------------------------------------------------------------ GSK3B_Hsap ------------------------------------------------------------ GSK3A_Hsap ------------------------------------------------------------ Pk34A_Dmel ------------------------------------------------------------ sgg_Dmel ------------------------------------------------------------ gskt_Dmel ------------------------------------------------------------ GSK3B_Mmus ------------------------------------------------------------ GSK3A_Mmus ------------------------------------------------------------ R03D7.5_Cele ------------------------------------------------------------ F21F3.2_Cele ------------------------------------------------------------ C44H4.6_Cele ------------------------------------------------------------ C36B1.10_Cele ------------------------------------------------------------ RIM11_Scer ------------------------------------------------------------ MRK1_Scer -----------T------------------------------------------------ MCK1_Scer ------------------------------------------------------------ Y106G6D.4_Cele ------------------------------------------------------------ Y106G6E.1_Cele ------------------------------------------------------------ Y18D10A.5_Cele ------------------------------------------------------------ YOL128C_Scer ------------------------------------------------------------ GlkA_Ddis ------------------------------------------------------------ GSK-3_Ddis ------------------------------------------------------------ 19912_Tthe -----------SPQ---------------------------------------------- 19923_Tthe -----------QD----------------------------------------------- 19924_Tthe ------------K----------------------------------------------- 2636_Tthe ------------------------------------------------------------ 5825_Tthe ------------------------------------------------------------ 7876_Tthe ------------------------------------------------------------ GSK3_Spur ------------------------------------------------------------ n1163_Tthe KNLQGKGAIDLRPPTSSQFQKTISFLERMRDKQIDRNKRQQQIKLAEKEQMTDHSLTNLF CC1G_03802_Ccin ------------------------------------------------------------ AqueK117_Aque ------------------------------------------------------------ GSK_b_Smoe ------------------------------------------------------------ GSK_a-2_Smoe -----------TDH---------------------------------------------- GSK_a-1_Smoe -----------TDH---------------------------------------------- GK035_Glam ------------------------------------------------------------ GK036_Glam ------------------------------------------------------------ GSK3B_Hsap ------------------------------------------------------------ GSK3A_Hsap ------------------------------------------------------------ Pk34A_Dmel ------------------------------------------------------------ sgg_Dmel ------------------------------------------------------------ gskt_Dmel ------------------------------------------------------------ GSK3B_Mmus ------------------------------------------------------------ GSK3A_Mmus ------------------------------------------------------------ R03D7.5_Cele ------------------------------------------------------------ F21F3.2_Cele ------------------------------------------------------------ C44H4.6_Cele ------------------------------------------------------------ C36B1.10_Cele ------------------------------------------------------------ RIM11_Scer ------------------------------------------------------------ MRK1_Scer ------------------------------------------------------------ MCK1_Scer ------------------------------------------------------------ Y106G6D.4_Cele ------------------------------------------------------------ Y106G6E.1_Cele ------------------------------------------------------------ Y18D10A.5_Cele ------------------------------------------------------------ YOL128C_Scer ------------------------------------------------------------ GlkA_Ddis ------------------------------------------------------------ GSK-3_Ddis --------------------------------------------------------DK-K 19912_Tthe --------------------------------------AKNKKYNYGGGGDFFTQKI--- 19923_Tthe --------------------------------------PKVQ-------------KL--- 19924_Tthe --------------------------------------KQQQ-------------KI--- 2636_Tthe ------------------------------------------------------------ 5825_Tthe --------------------------------------QQQQ-------------Q---- 7876_Tthe ------------------------------------------------------------ GSK3_Spur ------------------------------------------------------------ n1163_Tthe IEQVLISFSNQLIIKQNKQSKQSANNQLQKKESKTGNQKRKK-------------KI--- CC1G_03802_Ccin ------------------------------------------------------------ AqueK117_Aque ------------------------------------------------------------ GSK_b_Smoe --------------------------------------------------------VEAA GSK_a-2_Smoe --------------------------------------SDDK-------------ELEAT GSK_a-1_Smoe --------------------------------------SDDK-------------ELEAT GK035_Glam ------------------------------------------------------------ GK036_Glam ------------------------------------------------------------ GSK3B_Hsap --------------D--GSK--V------------------------------------- GSK3A_Hsap --------------D--SGK--V------------------------------------- Pk34A_Dmel ------------------IP--K------------------------------------- sgg_Dmel --------------D--GSK--I------------------------------------- gskt_Dmel -----------------TNK--V------------------------------------- GSK3B_Mmus --------------D--GSK--V------------------------------------- GSK3A_Mmus --------------D--SGK--V------------------------------------- R03D7.5_Cele ------------------------------------------------------------ F21F3.2_Cele ------------------------------------------------------------ C44H4.6_Cele --------------E--HVT--F------------------------------------- C36B1.10_Cele ------------------------------------------------------------ RIM11_Scer --------------V--SKQ--V------------------------------------- MRK1_Scer --DGK--VANKHENI--SSK--L------------------------------------- MCK1_Scer --------------G--SEF--I------------------------------------- Y106G6D.4_Cele ------------------------------------------------------------ Y106G6E.1_Cele ------------------------------------------------------------ Y18D10A.5_Cele --------------S--GKQ--V------------------------------------- YOL128C_Scer --------------D--EHY--F------------------------------------- GlkA_Ddis --------------N--SNH--S------------------------------------- GSK-3_Ddis ETDD----------N--GNK-KT------------------------------------- 19912_Tthe -SKKQPSLHTQQS-NSTYNQLRS------------------------------------- 19923_Tthe ---------------------QI------------------------------------- 19924_Tthe ---------------------QM------------------------------------- 2636_Tthe --------------L--AD---D------------------------------------- 5825_Tthe ------------------------------------------------------------ 7876_Tthe ------------------------------------------------------------ GSK3_Spur --------------D--SSK--I------------------------------------- n1163_Tthe ---------------------QFQMNNMKKQYGQPMNVSQSQGNVMQSQNLQQQQLAQQQ CC1G_03802_Ccin --------------D--PHK--V------------------------------------- AqueK117_Aque --------------D-TGHR--I------------------------------------- GSK_b_Smoe VIDG----------N--GTE--T------------------------------------- GSK_a-2_Smoe VVDG----------N--GTE--T------------------------------------- GSK_a-1_Smoe VVDG----------N--GTE--T------------------------------------- GK035_Glam ----------------------F------------------------------------- GK036_Glam -----------------ELQ--L------------------------------------- GSK3B_Hsap ----TT-----VV-----------------------ATP-G-QGP------------DRP GSK3A_Hsap ----TT-----VV-----------------------ATL-G-QGP------------ERS Pk34A_Dmel ----NS-----VI-----------------------STYAVGRLC------------SEP sgg_Dmel ----TT-----VV-----------------------ATP-G-QGT------------DRV gskt_Dmel ----TT-----VV-----------------------ATN-A-FGA------------DVM GSK3B_Mmus ----TT-----VV-----------------------ATP-G-QGP------------DRP GSK3A_Mmus ----TT-----VV-----------------------ATV-G-QGP------------ERS R03D7.5_Cele -----L-----E------------------------VWKL--IEV------------HKT F21F3.2_Cele ------------E-----------------------AYEM--PAD------------NKK C44H4.6_Cele ----HT-----VM-----------------------AKRGTGSKL------------DRE C36B1.10_Cele -----------IV-----------------------AQR---LED------------GRD RIM11_Scer ----YY------------------------------AHPPPTIDP------------NDP MRK1_Scer ----SKEKVEKMINFDYRYIKTKERTIHKRVYKHDRKTDVDRKNH------------GGT MCK1_Scer ----AD-----DV-------------------------T-S-NKS------------NNT Y106G6D.4_Cele -----F-----QI-----------------------AYEL--PS-------------QQR Y106G6E.1_Cele -----------IV-----------------------AQR---LED------------GKD Y18D10A.5_Cele ----TM-----VV-----------------------ASV-ATDGV------------DQQ YOL128C_Scer ----ID-----DI-------------------------V-S-IKN------------RQK GlkA_Ddis ----SS-----QS-----------------------S-STA-TVN------------SNP GSK-3_Ddis ----TT-----TT-----------------------SSSSSSSSSSKPRSNKFDKVIIKS 19912_Tthe ----SS-LTNRFN-----------------------KTP--SRLF------------NIN 19923_Tthe ----LK-----RI-----------------------YE-IQFTQQ------------QKE 19924_Tthe ----T------YF-----------------------YN-EKQQAG------------NYT 2636_Tthe ----TI-----KV-----------------------F-PLL-KLD------------KMI 5825_Tthe ------------L-----------------------QQ-QQQEQL------------QYS 7876_Tthe ------------L-----------------------DH--KG------------------ GSK3_Spur ----TS-----VT-----------------------ATK-G-PPP------------DRA n1163_Tthe QAQQQQ-----QL-----------------------QQ-QQQEQL------------QYS CC1G_03802_Ccin ----VR-----VI-----------------------ASD-G-KT-------------GET AqueK117_Aque ----MT-----VM-----------------------GTL-G-PLP------------DRQ GSK_b_Smoe ----GH-----II-----------------------ATTIGGRNG------------QPK GSK_a-2_Smoe ----GH-----II-----------------------ATTIGGRNG------------QPK GSK_a-1_Smoe ----GH-----II-----------------------ATTIGGRNG------------QPK GK035_Glam ----QD-----ST-----------------------ATC-P-QS-------------TDG GK036_Glam ----GK-----AL-------------------------DI--PGE------------KGE GSK3B_Hsap QEVSYTDTKVIGNGSFGVVYQAK-------------LC---DSG----ELVAIKKVLQDK GSK3A_Hsap QEVAYTDIKVIGNGSFGVVYQAR-------------LA---ETR----ELVAIKKVLQDK Pk34A_Dmel ALVRIEVKDLIGSGSFGRVYQAH-------------VN---ESE----EIVAVKQTLYNP sgg_Dmel QEVSYTDTKVIGNGSFGVVFQAK-------------LC---DTG----ELVAIKKVLQDR gskt_Dmel SEISYTDAKVVGNGSFGVVFQAK-------------MV---PSN----EMVAIKKVLQDR GSK3B_Mmus QEVSYTDTKVIGNGSFGVVYQAK-------------LC---DSG----ELVAIKKVLQDK GSK3A_Mmus QEVAYTDIKVIGNGSFGVVYQAR-------------LA---ETR----ELVAIKKVLQDK R03D7.5_Cele TKKAISAHKLCGSGRFSNVYCGQ-------------MI---SP-IE--KEVAVKNVWSDT F21F3.2_Cele VMLKIEEVHLHSCGVFSNVYKGI-------------LR---EP-YE--KKIAIKKSWPEK C44H4.6_Cele VEIQFTNLQLIGTGSFGAVYKAV-------------LR---END----EPIAIKKIKVDD C36B1.10_Cele MNLSLQNMNLFASGAFSNVYRGI-------------ART--ESNHQ--MEIVIKKTWPRH RIM11_Scer VQISFPTTEVVGHGSFGVVFATV-------------IQ---ETN----EKVAIKKVLQDK MRK1_Scer IDISYPTTEVVGHGSFGVVVTTV-------------II---ETN----QKVAIKKVLQDR MCK1_Scer RRMLVKEYRKIGRGAFGTVVQAY-------------LT---QDKKNWLGPFAIKKVPAHT Y106G6D.4_Cele VGMQMANLRLHARGVFSNVYRGT-------------IL---SPGTE--QEIAIKKTWPKT Y106G6E.1_Cele MHLNLHHMNLFATGAFSNVYRGV-------------AQT--ESNQE--IDIVIKKTWPRH Y18D10A.5_Cele VEISYYDQKVIGNGSFGVVFLAK-------------LS---TTN----EMVAIKKVLQDK YOL128C_Scer SKMYVREGKRIGHGSFGTVTQSI-------------LS---SNSIEWLGPYAIKRVVKSP GlkA_Ddis KVYPYEIIKQVGQGTFGKVYEAK-------------NQ---D-N----KRVAIKKVEKSN GSK-3_Ddis NGVCYITEGVIGNGSFGVVTQAI-------------VA---DTK----EVVAIKKVLQDQ 19912_Tthe QNLDIDENNKIGQGNFGVVFKAE-------------FK---DTK----EEVAVKRVLQDK 19923_Tthe YTYSIQGDNIVGNGTFGA----T-------------IN---ETG----ETVAIKKVFQDR 19924_Tthe YTIVGDEDKVVGSGTFGVVYQAT-------------TK---ETG----EVVAIKKVFQDK 2636_Tthe PLPNYEIKRVIGSGSFGYVFEAY-------------DN---NNQ----RTVALKRIQKVG 5825_Tthe GSPNITLDKIIGNGTFGVVYLAK-------------MN---DTQ----EQVAIKKVFQDK 7876_Tthe PPKDLKIIDVVGNGTFGVVYKKLDDNINFNYLKMKALL---NKE----QVVAVKRVFQDK GSK3_Spur EEISYTDTRVIGNGSFGVVYQAR-------------MV---DSS----DLVAIKKVLQDK n1163_Tthe GSPNITLDKIIGNGTFGVVYLAK-------------MN---DTQ----EQVAIKKVFQDK CC1G_03802_Ccin RELSYTNCKVIGNGSFGVVFQAR-------------LLGVPKDQ----EDIAIKKVLQDK AqueK117_Aque QEITYTDLKVIGSGSFGVVYQAK-------------IL---ETN----EPIAIKKVLQDK GSK_b_Smoe QTISYVAERVVGTGSFGIVFQAK-------------CL---ETG----ETVAIKKVLQDK GSK_a-2_Smoe QTISYVAERVVGTGSFGIVFQAK-------------CL---ETG----ETVAIKKVLQDK GSK_a-1_Smoe QTISYVAERVVGTGSFGIVFQAK-------------CL---ETG----ETVAIKKVLQDK GK035_Glam PEITFTTMRTIGSGSFGVVFIAK-------------T----STG----ELIAIKKVFQDR GK036_Glam EGIQVVPEKVIGKGSFGVVYLVK-------------SL---KGN----TPLALKLVLQDR . * *. .:* GSK3B_Hsap RFKN------RELQIM---RKL-DHCNIVRLR-YFFYSSGE------------------- GSK3A_Hsap RFKN------RELQIM---RKL-DHCNIVRLR-YFFYSSGE------------------- Pk34A_Dmel KLSQ------GEAEIMGQL--K-DHNNIVRLI-MHSSVSLG------------------- sgg_Dmel RFKN------RELQIM---RKL-EHCNIVKLL-YFFYSSGE------------------- gskt_Dmel RFKN------RELQIM---RKL-RHDNIITLK-WFFFSSGE------------------- GSK3B_Mmus RFKN------RELQIM---RKL-DHCNIVRLR-YFFYSSGE------------------- GSK3A_Mmus RFKN------RELQIM---RKL-DHCNIVRLR-YFFYSSGE------------------- R03D7.5_Cele ETRHLATSEYPEIQIL---SKL-FHPAISNLL-YFYSRNAND------------------ F21F3.2_Cele GERN------FEFIFLTGRERA-KHKNVIHMI-FAFSHSYDT------------------ C44H4.6_Cele RFKS------RELTIM---HEM-DHPNIIRLL-YYYVM---------------------- C36B1.10_Cele KGCP------LEVKILGKLGKL-KHKNIVRLL-FSY-QK-Q------------------- RIM11_Scer RFKN------RELEIM---KML-SHINIIDLK-YFFYERD-------------------- MRK1_Scer RYKN------RELETM---KML-CHPNTVGLQ-YYFYEKD-------------------- MCK1_Scer EYKS------RELQIL---RIA-DHPNIVKLQ-YFFTHLSP------------------- Y106G6D.4_Cele PYRN------FELLFLSGLRRK-PHKNIVQML-FAFSRNTTSGEGLE------------- Y106G6E.1_Cele KGCP------MEVKILGQLGKL-KHRNIVRLL-YSY-QK-Q------------------- Y18D10A.5_Cele RFKN------RELQIM---RKL-NHPNIVKLK-YFFYSSGE------------------- YOL128C_Scer KVQS------LELEIL---QNI-RHPNLVTLE-FFFESHCT------------------- GlkA_Ddis HFIS------REYDIL---KIVA-HPNCLRIL-DMFYTAE-------------------- GSK-3_Ddis RYKN------RELQIM---KML-NHINIVSLK-NSFYTS--------------------- 19912_Tthe NFKN------RELQIM---QEVAHHPNIVQLK-YSFYSFGE------------------- 19923_Tthe RYKN------RELQIM---KEIGNHPNVISLR-NYFYIYADD------------------ 19924_Tthe RYKN------RELQMM---KEIGNHPNVIKLR-NHYYSYG-N------------------ 2636_Tthe KKLS------REYEIL---LDIKDCDYVVKMI-DLYYSKT-------------------- 5825_Tthe RYKN------REFEII---KSL-NHQNLIKLK-QAYYTTQNN------------------ 7876_Tthe RYKN------REREII---ERL-DHQNIIKCK-DFFETKGE------------------- GSK3_Spur RFKN------RELQIM---RRL-DHHNIVKLK-YFFYSSGE------------------- n1163_Tthe RYKN------REFEII---KSL-NHQNLIKLK-QAYYTTQNN----NVDSFFFHTFNSKI CC1G_03802_Ccin RFKN------RELQIM---RLV-SHPNVVDLK-AFFYSNGD------------------- AqueK117_Aque RFKQ-------------------------------------------------------- GSK_b_Smoe RYKN------RELQIM---RLL-DHPSIVSLK-HCFFSTT-------------------- GSK_a-2_Smoe RYKN------RELQIM---RLL-DHPNIVALK-HCFFSTT-------------------- GSK_a-1_Smoe RYKN------RELQIM---RLL-DHPNIVALK-HCFFSTT-------------------- GK035_Glam KYRN------RELSIM---QELGQHPCIIRLI-NSYISVATN------------------ GK036_Glam RYKN------REFQIM---RTL-VHPCICRLVKGTFIPSIS------------------- GSK3B_Hsap ------------------------------------------------------------ GSK3A_Hsap ------------------------------------------------------------ Pk34A_Dmel ------------------------------------------------------------ sgg_Dmel ------------------------------------------------------------ gskt_Dmel ------------------------------------------------------------ GSK3B_Mmus ------------------------------------------------------------ GSK3A_Mmus ------------------------------------------------------------ R03D7.5_Cele ------------------------------------------------------------ F21F3.2_Cele ------------------------------------------------------------ C44H4.6_Cele ------------------------------------------------------------ C36B1.10_Cele ------------------------------------------------------------ RIM11_Scer ------------------------------------------------------------ MRK1_Scer ------------------------------------------------------------ MCK1_Scer ------------------------------------------------------------ Y106G6D.4_Cele ------------------------------------------------------------ Y106G6E.1_Cele ------------------------------------------------------------ Y18D10A.5_Cele ------------------------------------------------------------ YOL128C_Scer ------------------------------------------------------------ GlkA_Ddis ------------------------------------------------------------ GSK-3_Ddis ------------------------------------------------------------ 19912_Tthe ------------------------------------------------------------ 19923_Tthe ------------------------------------------------------------ 19924_Tthe ------------------------------------------------------------ 2636_Tthe ------------------------------------------------------------ 5825_Tthe ------------------------------------------------------------ 7876_Tthe ------------------------------------------------------------ GSK3_Spur ------------------------------------------------------------ n1163_Tthe NSQLRFFLRYKKTQNCLHSLIQFTRYIQKHSKKSNTKTLIQIFNLRELDFPASHPVFYTN CC1G_03802_Ccin ------------------------------------------------------------ AqueK117_Aque ------------------------------------------------------------ GSK_b_Smoe ------------------------------------------------------------ GSK_a-2_Smoe ------------------------------------------------------------ GSK_a-1_Smoe ------------------------------------------------------------ GK035_Glam ------------------------------------------------------------ GK036_Glam ------------------------------------------------------------ GSK3B_Hsap ----------KKDE--VY-LNLVLDYVPETVYRVARHYSR-------AKQTLPVIYVKLY GSK3A_Hsap ----------KKDE--LY-LNLVLEYVPETVYRVARHFTK-------AKLTIPILYVKVY Pk34A_Dmel ----------FPSV--DY-VLLVMEYMPMTLLDYINYHLTV------LQPAERLINVRIL sgg_Dmel ----------KRDE--VF-LNLVLEYIPETVYKVARQYAK-------TKQTIPINFIRLY gskt_Dmel ----------KRDE--VY-LNLVMEFLPETLYKVERQYAR-------AKQTLPVNFVRLY GSK3B_Mmus ----------KKDE--VY-LNLVLDYVPETVYRVARHYSR-------AKQTLPVIYVKLY GSK3A_Mmus ----------KKDE--LY-LNLVLEYVPETVYRVARHFTK-------AKLITPIIYIKVY R03D7.5_Cele -------------K--VI-NCLVLDYLPQDLARLRDQ-----------GVKFDVLDAKLY F21F3.2_Cele -------------K--VC-ESYVFDFMPNTLAEVIRQ-------------KLTDLDIRLY C44H4.6_Cele -----------QQE--NC-LNFVMEFMPKDLAYVHRQFAH-------NDKQMPAYSIKLY C36B1.10_Cele ----------HEGR--IC-LGLIFEYIPMNLHQFLKDNN----------RRVDIIEVKLI RIM11_Scer ----------SQDE--IY-LNLILEYMPQSLYQRLRHFVH-------QRTPMSRLEIKYY MRK1_Scer ----------EEDE--VY-LNLVLDYMPQSLYQRLRHFVN-------LKMQMPRVEIKFY MCK1_Scer ----------QDNK--VY-QHLAMECLPETLQIEINRYVT-------NKLEMPLKHIRLY Y106G6D.4_Cele ----------MKHS--FC-ESYVFGFMPYTLQNILKK------------TRLAEVDMKLY Y106G6E.1_Cele ----------HEGR--IC-LALIFEYIPLNLYQFLKDKN----------RRIDIVEVKLI Y18D10A.5_Cele ----------KKDE--LY-LNLILEYVPETVYRVARHYSK-------QRQQIPMIYVKLY YOL128C_Scer ----------TKDGGHLYQKNFVMEYIPQTLSSEIHEYFD-------NGSKMPTKHIKLY GlkA_Ddis ----------D-NK--KM-QNLVFDFIPYTLASLLK------------KRQLSINFIKVL GSK-3_Ddis ----------DNDE--VY-LNLVLEYVPDTVYRVSRHYSM-------SKQPVPNIFVKLY 19912_Tthe ----------EEDD--VY-LNLIMEYVPSNLTKMIKYYHRKKLKQFEQREQFPNILIKLY 19923_Tthe ----------KQED--VY-LNIIMDYIPETLYRMIKYFAKK------SKGNFPNILLKLY 19924_Tthe ----------STDD--VY-LHLVMDFVPETLYKMIKYYSKK------HKGNFPNILLKYY 2636_Tthe ----------DDNK--LI-QNIVFEYMENNLEDHISKFNK-------SKKVIPEQTVKEY 5825_Tthe ----------NPDE--VY-LNIVMEYVPETLSKVIRTYRK-------SKQPFPPLLLKVF 7876_Tthe ----------KKDE--VY-LNLVMEFMNFPLSKVIRDKRK-------ANQVMRIEDIRLY GSK3_Spur ----------KKDE--VF-LNLVLEYVPETVYRVARHYSK-------AKQTIANLYVKLY n1163_Tthe PILTRRYSTVIPDE--VY-LNIVMEYVPETLSKVIRTYRK-------SKQPFPPLLLKVF CC1G_03802_Ccin ----------KKDE--VY-LNLVLEYVPETVYRASRHYSK-------LKQPMPMLQIKLY AqueK117_Aque -----------KDE--VY-LNLVLDYIPDTVYRVIRHHYK-------AKQIMPMLFIKLY GSK_b_Smoe ----------DKDE--LY-LNLVLEYVPETVYRIAKHYNR-------MNQRMPLLYVKLY GSK_a-2_Smoe ----------DKDE--LY-LNLVLEYVPETVYRIAKHHNR-------MNQRMPLLYVKLY GSK_a-1_Smoe ----------DKDE--LY-LNLVLEYVPETVYRIAKHHNR-------MNQRMPLLYVKLY GK035_Glam ----------QTNG--DF-LNILMDYYQENGYQIYKSYIR-------AGIKMPMFHIKLY GK036_Glam ----------SPDD--LI-LYLLMDYYPETIHSIYRQYSR-------LRQHVPLLIVRLI : : GSK3B_Hsap MYQLFRSLAYIHS-FGICHRDIKPQNLLLDPD--TAVLKLCDFGSAKQLVRG-------- GSK3A_Hsap MYQLFRSLAYIHS-QGVCHRDIKPQNLLVDPD--TAVLKLCDFGSAKQLVRG-------- Pk34A_Dmel SYQMFRGLGYLHL-LGISHRDVKPENLLIDNQ--KMVLKLSDFGSAKLLVPQ-------- sgg_Dmel MYQLFRSLAYIHS-LGICHRDIKPQNLLLDPE--TAVLKLCDFGSAKQLLHG-------- gskt_Dmel MYQLLRSMGYLHS-LGFCHRDIKPQNMLLDSE--TGVLKLCDFGSAKQLISG-------- GSK3B_Mmus MYQLFRSLAYIHS-FGICHRDIKPQNLLLDPD--TAVLKLCDFGSAKQLVRG-------- GSK3A_Mmus MYQLFRSLAYIHS-QGVCHRDIKPQNLLVDPD--TAVLKLCDFGSAKQLVRG-------- R03D7.5_Cele TFQLFCAISHLTS-KNIVHMDIKPQNVVMDRM--AGRLKLADFGNARRLETN-------- F21F3.2_Cele TWQIFSGLKYLEE-HKVVHRDLKPVNILVDHD--TAFLKISDFGSAKIIVKG-------- C44H4.6_Cele MFQLLRGIGFLHL-HNIVHRDIKPKNLLVDES--NGILKICDFGSAKRLEKN-------- C36B1.10_Cele VWQLFRGQAHLEK-SEICHRDIKPQNLLYNAD--TGLLKISDYGSSAIESVK-------- RIM11_Scer MFQLFKSLNYLHHFANVCHRDIKPQNLLVDPE--TWSLKLCDFGSAKQLKPT-------- MRK1_Scer AYQLFKALNYLHNVPRICHRDIKPQNLLVDPT--TFSFKICDFGSAKCLKPD-------- MCK1_Scer TYQIARGMLYLHG-LGVCHRDIKPSNVLVDPE--TGVLKICDFGSAKKLEHN-------- Y106G6D.4_Cele TWQLFEGIRYLQA-HMIVHRDIKPVNILVDVD--KGTLKIADFGSAKVVLRG-------- Y106G6E.1_Cele VWQLFRGQAHLEK-ADICHRDIKPQNLLYNAE--TGLLKISDFGSSSIQSTK-------- Y18D10A.5_Cele MYQLLRSLAYIHS-IGICHRDIKPQNLLIDPE--SGVLKLCDFGSAKYLVRN-------- YOL128C_Scer TFQILRALLTLHS-MSICHGDLKPSNILIIPS--SGIAKVCDFGSAQRLDDN-------- GlkA_Ddis FYQLCQAIKHIHS-KAICHRDITPNNILLSS---KGELTLADFGSAKILESN-------- GSK-3_Ddis IYQLCRSINYIHS-LGICHRDIKPQNLLLDTS--TSTLKLCDFGSAKILIKG-------- 19912_Tthe LYQAFRALAYLNG-LNIAHRDIKPSNILINHR--THQLKFCDFGSAKKLSRG-------- 19923_Tthe SYQLMRSLAYIQG-LGICHRDIKPTNVLVDPR--NHALKMCDFGSAKKLNPS-------- 19924_Tthe SYQMLRSLAYIHG-INICHRDIKPQNILVDPR--NHNLKMCDFGSAKKLVPG-------- 2636_Tthe AYQILKGLQYIHS-KGIAHRDLKPDNILLND---DGKVKICDFGGSKYIDEK-------- 5825_Tthe SYQMFRALAYLKG-IGICHRDIKPQNILCDQK--TMQLKICDFGSAKKLIKG-------- 7876_Tthe AYQMFKALSYLQS-LNICHRDIKPQNILVNDKDDDKRLKICDFGSAKQLIPN-------- GSK3_Spur MYQLFRSLAYIHS-MGICHRDIKPQNLLLNPE--TAVLKLCDFGSAKVLVRG-------- n1163_Tthe SYQMFRALAYLKG-IGICHRDIKPQNILCDQK--TMQLKICDFGSAKKLIKGKLDILFVS CC1G_03802_Ccin MYQLLRSLAYIHS-VGICHRDIKPQNLLLNPS--TGVLKLCDFGSAKILVAG-------- AqueK117_Aque MYQLFRALGYIHA-NGVCHRDIKPQNLLLNPE--TGVLKLCDFGSAKVLVRG-------- GSK_b_Smoe TYQICRALTYIHGGMGVCHRDIKPQNLLVNPH--THQLKLCDFGSAKVLVKG-------- GSK_a-2_Smoe TYQICRSLAYIHGGIGVCHRDIKPQNLLVNPH--THQLKLCDFGSAKVLVKG-------- GSK_a-1_Smoe TYQICRSLAYIHGGIGVCHRDIKPQNLLVNPH--THQLKLCDFGSAKVLVKG-------- GK035_Glam TFQFLRGLAYMHS-FNIANRDLKPQNTLVNRE--SGRAVLCDLGSAKKLNPA-------- GK036_Glam TYQLARSLAYLHY-HNIAHRDCKPTNVLIDPL--TYRCVLCDFGSAKQLVPQ-------- :* . : . : * .* * : ..* *.: GSK3B_Hsap ------------------------------------------------------EP-NVS GSK3A_Hsap ------------------------------------------------------EP-NVS Pk34A_Dmel ------------------------------------------------------EP-SIS sgg_Dmel ------------------------------------------------------EP-NVS gskt_Dmel ------------------------------------------------------EP-NVS GSK3B_Mmus ------------------------------------------------------EP-NVS GSK3A_Mmus ------------------------------------------------------EP-NVS R03D7.5_Cele ------------------------------------------------------EKTGSA F21F3.2_Cele ------------------------------------------------------KA-NNF C44H4.6_Cele ------------------------------------------------------EP-NIT C36B1.10_Cele ------------------------------------------------------TP-QQS RIM11_Scer ------------------------------------------------------EP-NVS MRK1_Scer ------------------------------------------------------QP-NVS MCK1_Scer ------------------------------------------------------QP-SIS Y106G6D.4_Cele ------------------------------------------------------SS-STS Y106G6E.1_Cele ------------------------------------------------------SP-QQS Y18D10A.5_Cele ------------------------------------------------------EP-NVS YOL128C_Scer ------------------------------------------------------TE-LKT GlkA_Ddis ------------------------------------------------------HT-SMS GSK-3_Ddis ------------------------------------------------------ET-NVS 19912_Tthe ------------------------------------------------------ES-NIS 19923_Tthe ------------------------------------------------------ET-NIS 19924_Tthe ------------------------------------------------------ES-NIS 2636_Tthe ------------------------------------------------------GK-NTP 5825_Tthe ------------------------------------------------------EP-NVS 7876_Tthe ------------------------------------------------------EA-NIS GSK3_Spur ------------------------------------------------------EP-NVS n1163_Tthe YSSVVSKNLVFILISSLTAKKQIDYQQFLFKSNKKPKQLLNIQTAPFNKHQKQSEP-NVS CC1G_03802_Ccin ------------------------------------------------------EP-NVS AqueK117_Aque ------------------------------------------------------EP-NVS GSK_b_Smoe ------------------------------------------------------EP-NIS GSK_a-2_Smoe ------------------------------------------------------EP-NIS GSK_a-1_Smoe ------------------------------------------------------EP-NIS GK035_Glam ------------------------------------------------------EP-NIA GK036_Glam ------------------------------------------------------EN-NVA GSK3B_Hsap YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGD-SGVDQLVEIIKVLG GSK3A_Hsap YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGD-SGVDQLVEIIKVLG Pk34A_Dmel YICSRLYRAPELFAGYELYSCAVDIWSAGCVLAELLKGYPLFSSHKHDRKQLRLIVNMLG sgg_Dmel YICSRYYRAPELIFGAINYTTKIDVWSAGCVLAELLLGQPIFPGD-SGVDQLVEVIKVLG gskt_Dmel YICSRYYRAPELIFGSTDYTTKIDMWSAGCVMSELLLGQLIFPGD-SGVDQIVEIVKVMG GSK3B_Mmus YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGD-SGVDQLVEIIKVLG GSK3A_Mmus YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGD-SGVDQLVEIIKVLG R03D7.5_Cele YQVTRFYRPPELLFGCEKFTASIDIWSATCVAFELFANRVLFKGK-DTKDQIVLITGVFG F21F3.2_Cele YQVTRFYRPPELLMKAMEYNSTVDVWSAGCIMAEMVKRHVVFPGR-DSAHQLKLYCRCFG C44H4.6_Cele YICSRYYRAPELIFGSKNYDTSIDTWSVGTVVGELLHNSPIFLAD-SAVDILALQIKAFG C36B1.10_Cele YHVTRYYRPPELLLGSKNYGCKIDTWSCGCVFGELLKGGIFLAGK-SAKNQAEVVFDMFG RIM11_Scer YICSRYYRAPELIFGATNYTNQIDIWSSGCVMAELLLGQPMFPGE-SGIDQLVEIIKILG MRK1_Scer YICSRYYRAPELMFGATNYSNQVDVWSSACVIAELLLGKPLFSGE-SGIDQLVEIIKIMG MCK1_Scer YICSRFYRAPELIIGCTQYTTQIDIWGLGCVMGEMLIGKAIFQGQ-EPLLQLREIAKLLG Y106G6D.4_Cele YQVTRFYRPPELLLDAKEYYWMVDVWSAGCCVGEMMKGKVLFPGA-SIKIMLKLIVQAIG Y106G6E.1_Cele YHVTRYYRPPELILGSKYYGCKIDTWSCGCVFGELLKGGIILAGK-SSNNQAEVIFDMLG Y18D10A.5_Cele YICSRYYRAPELIFGATNYTNSIDVWSAGTVMAELLLGQPIFPGD-SGVDQLVEIIKVLG YOL128C_Scer YFCSRFYRAPELLLNSKDYTTQIDIWSLGCIIGEMIKGQPLFKGD-SANSQLEEIAKLLG GlkA_Ddis YICSRYYRAPELLVGCSNYTTKIDIWSIGCILAEMLIGKPLFPGT-NSNDQLGRIIEVLG GSK-3_Ddis YICSRHYRAPELIFGSTNYTTTIDVWSLGCVLAELLLGQPLFPGE-NGIDQLVEIIKVLG 19912_Tthe YICSRFYRAPELMLGASNYTTSVDVWSLGCVVAEMLLGEPLFKGN-SSLDQLVEVMKVLG 19923_Tthe YICSRYYRAPELMFMATQYTNSIDVWSVGCVIAEMVLGDPIFAGE-SSVDQLIEIIKILG 19924_Tthe YICSRCYRAPELMFQATQYTHAIDVWSVGCVIAEMVLGQPIFIGE-SSVDQLIEIIKVLG 2636_Tthe YIVSRYYRAPELILCITKYNQKIDMWSFGCILGELVTTFPLFQGK-TEGDQLFSIFKVLG 5825_Tthe YICSRYYRAPELIFGAEQYTTAIDTWSIGTVIAEMILGEPLFPGE-NAVEQLVEIIKILG 7876_Tthe YICSRYYRAPELIFKSQHYTNAIDMWSMGCVIAEMVLGEPLFPGE-NSLDQLVEIIRILG GSK3_Spur YICSRYYRAPELIFGATDYTCDIDVWSAGCVLAELLLGQPIFPGD-SGVDQLVEIIKVLG n1163_Tthe YICSRYYRAPELIFGAEQYTTAIDTWSIGTVIAEMILGEPLFPGE-NAVEQLVEIIKILG CC1G_03802_Ccin YICSRYYRAPELIFGATNYTTNIDIWSTGCVMAELMLGQPLFPGE-SGIDQLVEIIKVLG AqueK117_Aque YICSRYYRAPELIFGATDYTVNIDIWSAGCVFAELLLGQPIFPGD-SGVDQLVEIIKILG GSK_b_Smoe YICSRYYRAPELIFGATDYTTAIDIWSTGCVLAELLLGQPLFPGE-SGVDQLVEIIKVLG GSK_a-2_Smoe YICSRYYRAPELIFGATEYTTAIDIWSMGCVLAELLLGQPLFPGE-SGVDQLVEIIKVLG GSK_a-1_Smoe YICSRYYRAPELIFGATEYTTAIDIWSMGCVLAELLLGQPLFPGE-SGVDQLVEIIKVLG GK035_Glam YICSRYYRAPELIFGSRYYTTVIDIWSFGCVVAEMIIGKPIYAGS-SPLDQIIEIIKILG GK036_Glam YICSRFYRAPELVIGNQNYTCAIDIWSFGCIMAEILLGQPLFPGD-SSIDQLVEIVRVLG * :* **.***. : :* *. *:. . . :* GSK3B_Hsap TPTREQIREMNPNYT--EFKF------------------------PQ------IKA---- GSK3A_Hsap TPTREQIREMNPNYT--EFKF------------------------PQ------IKA---- Pk34A_Dmel TDGLERAPEILSKCG--NSLH------------------------PR------TTR---- sgg_Dmel TPTREQIREMNPNYT--EFKF------------------------PQ------IKS---- gskt_Dmel TPTSEQLHDMNPHYK--QFKL------------------------PE------LKP---- GSK3B_Mmus TPTREQIREMNPNYT--EFKF------------------------PQ------IKA---- GSK3A_Mmus TPTREQIREMNPNYT--EFKF------------------------PQ------IKA---- R03D7.5_Cele YPTDDDIKSIGVKRP--RVARKDARGIETVKIKEKTNKTKKEAKQSTLVHEKYTRARAMS F21F3.2_Cele APNEQDISAMKGEKL--EKEYWKF-----------------------------TKG---- C44H4.6_Cele TPSKEDMAKWNYEYV--HIPY------------------------DT------ITG---- C36B1.10_Cele VPTAEDVSSMNVSNT--KYKE-------------------------I------IQS---- RIM11_Scer TPSKQEICSMNPNYM--EHKF------------------------PQ------IKP---- MRK1_Scer IPTKDEISGMNPNYE--DHVF------------------------PN------IKP---- MCK1_Scer PPDKRFIFFSNPAYD--GPLFSK---P----------------LFSG------SSQ---- Y106G6D.4_Cele LPSARDLDYMKVSSM--IDQQSA------------------------------VKV---- Y106G6E.1_Cele YPTDSDVSSMKVSST--KLQE-------------------------V------LDS---- Y18D10A.5_Cele TPTREQIQSMNPNYK--EFKF------------------------PQ------IKA---- YOL128C_Scer RFPKSSIKNSQELQ----DSLND---Q----------------KFK-------------- GlkA_Ddis SPTKDDMEAMKPSKP--YHL-----------------------QLPN------INP---- GSK-3_Ddis TPTKEQIHAMNPYYT--SFKF------------------------PE------IKA---- 19912_Tthe APSPEQIREMNPEHK--LLKY------------------------PP------INK---- 19923_Tthe TPTLQQ--HMNPDHQ--PTQM------------------------PK------IKP---- 19924_Tthe TPTQQQIFAMNPDHQ--GTKM------------------------PN------IKP---- 2636_Tthe SPTKEEFQKFSERVPFDKKIFD---------------------EFQT------YEP---- 5825_Tthe TPTKEQVQKMNPQHN--QFNF------------------------PS------IKP---- 7876_Tthe TPTRQQILMMNPTSQ--EFRF------------------------PQ------IKS---- GSK3_Spur TPSRDQIKEMNPNYT--EFKF------------------------PQ------IKP---- n1163_Tthe TPTKEQVQKMNPQHN--QFNF------------------------PS------IKP---- CC1G_03802_Ccin TPSREQIKTMNPNYM--EHKF------------------------PQ------IKP---- AqueK117_Aque TPTKEQIRQMNPNYT--EFKF------------------------PQ------IKA---- GSK_b_Smoe TPTREEIKCMNPNYT--EFKF------------------------PQ------IKA---- GSK_a-2_Smoe TPTREEIKCMNPNYT--EFKF------------------------PQ------IKA---- GSK_a-1_Smoe TPTREEIKCMNPNYT--EFKF------------------------PQ------IKA---- GK035_Glam PPSLKELKEMNPTLK--EYAF------------------------PT------IRT---- GK036_Glam SPTAEEFLAMNPTLK--SVKF------------------------KD------VKR---- GSK3B_Hsap ----HP----------------------------WTKDSSGTGHFTSGVRVFR------- GSK3A_Hsap ----HP----------------------------WTK-------------VFK------- Pk34A_Dmel ----PS----------------------------WNY-------------LLN------- sgg_Dmel ----HP----------------------------WQK-------------VFR------- gskt_Dmel ----HP----------------------------WSK-------------VFR------- GSK3B_Mmus ----HP----------------------------WTKDSPGAGHFTPGVRVFR------- GSK3A_Mmus ----HP----------------------------WTK-------------VFK------- R03D7.5_Cele RSTENK----------------------------LAP-------------FTS------- F21F3.2_Cele ----FG----------------------------LQR-------------LVN------- C44H4.6_Cele ----VG----------------------------IQK-------------FIG------- C36B1.10_Cele ----YEPDTSKRTADLAYLYNQTASFQRDRRSTVYNT-------------KID------- RIM11_Scer ----IP----------------------------LSR-------------VFK------- MRK1_Scer ----IT----------------------------LAE-------------IFK------- MCK1_Scer ----QR----------------------------FEK-------------YFG------- Y106G6D.4_Cele ----IG----------------------------LKE-------------VLG------- Y106G6E.1_Cele ----YEYNKSKTTADLTYLYTQTVIYQKDRRTTVYNT-------------KIE------- Y18D10A.5_Cele ----HP----------------------------WNK-------------VFR------- YOL128C_Scer -----K----------------------------FMH-------------WFP------- GlkA_Ddis ----KF----------------------------FES--------------LH------- GSK-3_Ddis ----NP----------------------------WPR-------------VFK------- 19912_Tthe ----MP----------------------------LSK-------------ICQ------- 19923_Tthe ----TP----------------------------WSK-------------VFK------- 19924_Tthe ----TP----------------------------WTK-------------VFQ------- 2636_Tthe ----QN----------------------------LRK-------------MFF------- 5825_Tthe ----TS----------------------------WTK-------------IF-------- 7876_Tthe ----YS----------------------------WSK-------------VFEKSLQ--- GSK3_Spur ----HP----------------------------WNK-------------VFR------- n1163_Tthe ----TS----------------------------WTK-------------LIKQISTVIN CC1G_03802_Ccin ----HP----------------------------FSK-------------VFR------- AqueK117_Aque ----HA----------------------------WNK-------------VFR------- GSK_b_Smoe ----HP----------------------------WHK-------------VFH------- GSK_a-2_Smoe ----HP----------------------------WHK-------------VFH------- GSK_a-1_Smoe ----HP----------------------------WHK-------------VFH------- GK035_Glam ----TP----------------------------MSD-------------VLG------- GK036_Glam ----YP----------------------------FSK-------------IFR------- GSK3B_Hsap ----------------P-RTPP--EAIALCSRLLEYTPTARLTPLEACAHSFFDELRD-P GSK3A_Hsap ----------------S-RTPP--EAIALCSSLLEYTPSSRLSPLEACAHSFFDELRC-L Pk34A_Dmel ----------------T-AVPQ--DLCGLLNSCFIYEAAARISPMMACSHGSYDELRI-M sgg_Dmel ----------------I-RTPT--EAINLVSLLLEYTPSARITPLKACAHPFFDELRM-E gskt_Dmel ----------------I-RTPA--EAIDLVSKMLIYSPNARVSPLMGCAHPFFDELRQDP GSK3B_Mmus ----------------P-RTPP--EAIALCSRLLEYTPTARLTPLEACAHSFFDELRD-P GSK3A_Mmus ----------------SSKTPP--EAIALCSSLLEYTPSSRLSPLEACAHSFFDELRR-L R03D7.5_Cele -----------------KMLDS--EIYDFMKATLKIDPKKRKSAIDVLKMPLFDILRS-S F21F3.2_Cele -----------------D-ISP--DQLQFIKRILVYAPEKRLRGKQLLQDDFFRPLFK-A C44H4.6_Cele ----------------R-KLSL--STLELLNSLMKMDPKLRIKPYEALTLPYFDDLRD-P C36B1.10_Cele ----------------Y-SDMK--DSVELLRQVLVYNPSRRLCGIEFLTNPFFTVLFN-E RIM11_Scer ----------------K-E-DD--QTVEFLADVLKYDPLERFNALQCLCSPYFDELKL-D MRK1_Scer ----------------A-E-DP--DTLDLLTKTLKYHPCERLVPLQCLLSSYFDETKR-C MCK1_Scer -----------------H-SGP--DGIDLLMKILVYEPQQRLSPRRILAHQFFNELRN-D Y106G6D.4_Cele -----------------T-ENQ--EWADFLGAILRYRPRERLHGPKLLSHPFFDLIFT-P Y106G6E.1_Cele ----------------Q-DDMK--ESVAVLLQILVYNPNKRLSGIEILTHPYFNVLFN-E Y18D10A.5_Cele ----------------V-HTPA--EAIDLISKIIEYTPTSRPTPQAACQHAFFDELRN-P YOL128C_Scer -----------------S-IEF--FDVEFLLKVLTYDATERCDARQLMAHEFFDALRN-E GlkA_Ddis ----------------NV-EDK--TVVDLLSKIFIFDPVKRASIDEIIAHPFLRDVNIN- GSK-3_Ddis ----------------AKDVPA--ESIDLISKILLYDPSSRLKPVEICAHPFFDELRD-P 19912_Tthe ----------------N-KCQSMNHLKGLSLQKLYYIPILMN-----------------Q 19923_Tthe ----------------NCKVDP--LAIDLISKVLVYSPQLRLKPLEALAHPFFDELRN-P 19924_Tthe ----------------NCRIDP--LAIDLISKILVYNPEKRLKPLEALLHPFFEELRN-P 2636_Tthe ----------------YIKDID--NLMDLITKCLQYLPENRITADEALQHPFFKGLEE-- 5825_Tthe ---------------AKQKPDP--MLIDLISRLLVFVPTDRPTPLETLLHPYFNELRS-E 7876_Tthe -----------KVSEDEKQKFN--QLMDLISRVLVYAPSERPSPLQALAHPFFDELRI-E GSK3_Spur ----------------A-RTPA--DAIQLCSRLLEYTPKSRIKPLEACAHQFFSELRE-P n1163_Tthe KYSNKKQQQNANIF-AKQKPDP--MLIDLISRLLVFVPTDRPTPLETLLHPYFNELRS-E CC1G_03802_Ccin ----------------P-RTAP--EAIDLVSKLLEYTPGARLSAVEAMVHPFFDELRA-E AqueK117_Aque ----------------P-RTPP--EAIDLVSRLLEYTPTMRITTLDSCAHSFFDELRQ-P GSK_b_Smoe ----------------K-RMPP--EAVDLVSRLLQYSPSLRCNALEALVHPFFDELRD-P GSK_a-2_Smoe ----------------K-RMPP--EAVDLVSRLLQYSPNLRCSSLEALAHPFFDELRD-P GSK_a-1_Smoe ----------------K-RMPP--EAVDLVSRLLQYSPNLRCSSLEALAHPFFDELRD-P GK035_Glam ----------------T-K-DP--VVLDFFARCFKYSPNERITAYEALAHPFYDDLRA-R GK036_Glam ----------------S-KAHT--DAVDLLTKVLVYDPKKRPTAMEILAHPFYDILRD-P . : . GSK3B_Hsap N---VKLPNGRD----TPA-LFNFTTQ-ELS---------S-N--PP------LAT---- GSK3A_Hsap G---TQLPNNRP----LPP-LFNFSAG-ELS---------I-Q--PS------LNA---- Pk34A_Dmel DAMALPMPNGNP----LPP-LFDFNSL-EMG---------T-D--PK------LWV---- sgg_Dmel GN--HTLPNGRD----MPP-LFNFTEH-ELS---------I-Q--PS------LVP---- gskt_Dmel H---QQLPNGRS----LPP-LFNFTDY-EKT---------I-E--PD------TMP---- GSK3B_Mmus N---VKLPNGRD----TPA-LFNFTTQ-ELS---------S-N--PP------LAT---- GSK3A_Mmus G---AQLPNDRP----LPP-LFNFSPG-ELS---------I-Q--PS------LNA---- R03D7.5_Cele PP--KKRSNGVE----MPN-LASYTEM-HHK---------R-E--PE------T------ F21F3.2_Cele G---AVRHNGQK----ISD-VITAADY-KRA---------A-E--NEESSACRLAQLVKT C44H4.6_Cele H---YKLPSGAP----IPP-LFDWLER-EYI---------A-N--HE------IIK---- C36B1.10_Cele KT---VRFNKKK----IQC-VSAVDLQ-AVK----------------------------- RIM11_Scer D---GKINQITT----DLK-LLEFDENVEL---------GH-L----------------- MRK1_Scer D---TDTYVKAQ----NLR-IFDFDVETEL---------GH-V--PL------VER---- MCK1_Scer D---TFLPRGFTEPIKLPN-LFDFNDF-ELQ---------I-L--GE------FAD---- Y106G6D.4_Cele K---CTLSNGLL----VSQ-VITLDDY-KTA---------Q-K--NDSTSGKQYAAAILR Y106G6E.1_Cele KT---VRFNKKK----ILC-LSAVDLQ-SVK----------------------------- Y18D10A.5_Cele D---ARLPSGRP----LPT-LEMDGPM-GTG----------------------------- YOL128C_Scer T---YFLPRGSSMPVHLPD-LFNFSAS-EKR---------A-L--GE------YYN---- GlkA_Ddis S---LELFDE----M---K-CFSVSGN-GKS--------SL-TTNST------SSS---- GSK-3_Ddis K---TCLPDGKP----LPP-LFNFTIA-EQT--------SI-G--PK------LAK---- 19912_Tthe -E--QSI-AGQM----ER-DFHLYST-F---------Q---------------------- 19923_Tthe L---CRI-NGQK----LPE-LFNFTQI-IIQILFKLVEVNGYP--DE------LIN---- 19924_Tthe K---CRI-NGKP----LDN-LFNFTEA-EIG---------P-N--EE------LLQ---- 2636_Tthe ------------------------------------------------------------ 5825_Tthe K---FYE-QYTK----QID-LFNFSPE-E---------LKS-Q--PQ------LAS---- 7876_Tthe E---KKY-RQT-----QLY-LFDFPEA-KE--------QEY-Q--KQ------IEQ---- GSK3_Spur G---TKLPNGRE----LPP-LFNFSAS-ELV---------S-K--PS------LRT---- n1163_Tthe K---FYE-QYTK----QID-LFNFSPE-E---------LKS-Q--PQ------LAS---- CC1G_03802_Ccin G---AKMPNGKE----FPR-LFDFTRE-ELS---------V-R--PD------LIR---- AqueK117_Aque G---ANMPNGRD----FPP-LFNFSQQ-ELS---------I-C--PS------LES---- GSK_b_Smoe S---TRLPNGRP----LPA-LFNFKPL-ELK--------GA-S--QE------LLE---- GSK_a-2_Smoe N---TRLPNGRP----LPP-LYNFKQL-ELK--------GA-S--PE------LLN---- GSK_a-1_Smoe N---TRLPNGRP----LPP-LYNFKQL-ELK--------GA-S--PE------LLN---- GK035_Glam D---API--SKD----L-K-LFEFSEY-ERK--------AM-S--PE------LLS---- GK036_Glam D---TLLPNGER----LPAFLFEFTEE-ERK--------AA-G--PE------LMA---- GSK3B_Hsap ------------------------ILI-PPHA---------------------------- GSK3A_Hsap ------------------------ILI-PPHL---------------------------- Pk34A_Dmel ------------------------NLL-PIHL---------------------------- sgg_Dmel ------------------------QLL-PKHL---------------------------- gskt_Dmel ------------------------LLL-PRAQ---------------------------- GSK3B_Mmus ------------------------ILI-PPHA---------------------------- GSK3A_Mmus ------------------------ILI-PPHL---------------------------- R03D7.5_Cele ------------------------EVV-ADIQ---------------------------- F21F3.2_Cele DNKDLGIPYCEKSNSYENVYARRSTLI-PKEQ---------------------------- C44H4.6_Cele ------------------------DIF-PRSE---------------------------- C36B1.10_Cele ------------------------------------------------------------ RIM11_Scer --------------------------S-PDEL---------------------------- MRK1_Scer ------------------------PAI-EERL---------------------------- MCK1_Scer ------------------------KIK-P------------------------------- Y106G6D.4_Cele HEIRF---------------SLKAPIVHPPAPPAPPVVPMIDMISCRFLIFLSLLVTVFS Y106G6E.1_Cele ------------------------------------------------------------ Y18D10A.5_Cele ------------------------------------------------------------ YOL128C_Scer ------------------------LIV-P------------------------------- GlkA_Ddis ------------------------STT-AN-M---------------------------- GSK-3_Ddis ------------------------TLI-PSHA---------------------------- 19912_Tthe -----------------------KLLT-PKWY---------------------------- 19923_Tthe ------------------------KLI-PDWY---------------------------- 19924_Tthe ------------------------RLI-PDWY---------------------------- 2636_Tthe ------------------------------------------------------------ 5825_Tthe ------------------------QLI-PQWY---------------------------- 7876_Tthe -----------------------LKLI-PNGY---------------------------- GSK3_Spur ------------------------VLI-PPHA---------------------------- n1163_Tthe ------------------------QLI-PQWY---------------------------- CC1G_03802_Ccin ------------------------KLV-PPHA---------------------------- AqueK117_Aque ------------------------KLV-PPHY---------------------------- GSK_b_Smoe ------------------------RLI-PEHA---------------------------- GSK_a-2_Smoe ------------------------RLV-PEHA---------------------------- GSK_a-1_Smoe ------------------------RLV-PEHA---------------------------- GK035_Glam ------------------------KIR--------------------------------- GK036_Glam ------------------------VLT-KNR----------------------------- GSK3B_Hsap ----------RIQAAAS-T------------P-----------------T---------- GSK3A_Hsap ----------RSPAGTT-T------------L---------------------------- Pk34A_Dmel ----------SSM----------------------------------------------- sgg_Dmel ----------QNASGPG-G------------NRPSAGGAASIAASGSTSV---------- gskt_Dmel ----------GSSTTKEPS------------A-----------------A--HRNRNTAG GSK3B_Mmus ----------RIQAAAS-P------------P-----------------A---------- GSK3A_Mmus ----------RSPAGPA-S------------P-----------------L---------- R03D7.5_Cele ------------------------------------------------------------ F21F3.2_Cele ----------KMARDNK-S------------K-----------------EDSS------- C44H4.6_Cele ------------------------------------------------------------ C36B1.10_Cele -----------SG----------------------------------------------- RIM11_Scer ----------S------------------------------------------------- MRK1_Scer ----------K------------------------------------------------- MCK1_Scer ------------------------------------------------------------ Y106G6D.4_Cele LECYTGFTYLKAQSVGT-S------------K-----------------ETCP------- Y106G6E.1_Cele -----------SG----------------------------------------------- Y18D10A.5_Cele ------------------------------------------------------------ YOL128C_Scer ------------------------------------------------------------ GlkA_Ddis ----------TSLASSS-SNNKTTCSETYLSR---------------------------- GSK-3_Ddis ----------MNQIELP-S------------P-----------------L---------- 19912_Tthe ----------QLLKQ--------------------------------------------- 19923_Tthe ----------SQMCAGV------------------------------------------- 19924_Tthe ----------VQQL---------------------------------------------- 2636_Tthe ------------------------------------------------------------ 5825_Tthe ----------TSRREKE-S------------KL----------------I----NNSKQA 7876_Tthe ------------------------------------------------------------ GSK3_Spur ----------SHSQNSS-S------------T-----------------T---------- n1163_Tthe ----------TSRREKE-S------------KL----------------I----NNSKQA CC1G_03802_Ccin ----------EPELASR-S------------I-----------------A---------- AqueK117_Aque ----------HESLSSG-S------------SG----------------P---------- GSK_b_Smoe ----------RKQ----------------------------------------------- GSK_a-2_Smoe ----------RKQ----------------------------------------------- GSK_a-1_Smoe ----------RKQ----------------------------------------------- GK035_Glam ------------------------------------------------------------ GK036_Glam ------------------------------------------------------------ GSK3B_Hsap ----------------------------------------------------NA-----T GSK3A_Hsap --------------------------------------------------TPSS-----Q Pk34A_Dmel ------------------------------------------------------------ sgg_Dmel -------------------------------------SSTGSGASVEGSAQPQS-----Q gskt_Dmel E-ESPRKTED--------------------------------------SQKPAT-----A GSK3B_Mmus ----------------------------------------------------NA-----T GSK3A_Mmus ----------------------------------------------TTSYNPSS-----Q R03D7.5_Cele ------------------------------------------------------------ F21F3.2_Cele --------------------------------------------------DDRR------ C44H4.6_Cele ------------------------------------------------------------ C36B1.10_Cele ------------------------------------------------------------ RIM11_Scer ------------------------------------------------------------ MRK1_Scer ------------------------------------------------------------ MCK1_Scer ------------------------------------------------------------ Y106G6D.4_Cele --------------------------------------------------SPND-----Y Y106G6E.1_Cele ------------------------------------------------------------ Y18D10A.5_Cele ------------------------------------------------------------ YOL128C_Scer ------------------------------------------------------------ GlkA_Ddis --------------------------------------------------LPTS------ GSK-3_Ddis ---------FPNLAISSSNQS-SSSNSNANVSSNLNSHSASPSTTSSSSSTPNSIPVQSP 19912_Tthe ------------------------------------------------------------ 19923_Tthe ------------------------------------------------------------ 19924_Tthe ------------------------------------------------------------ 2636_Tthe ------------------------------------------------------------ 5825_Tthe EQQQSQL--VNQLT-NEFNQKMDISNSQ----KNING----------------------- 7876_Tthe ------------------------------------------------------------ GSK3_Spur --------------------------------------------------VPH------- n1163_Tthe EQQQSQL--VNQLT-NEFNQKMDISNSQ----KNING----------------------- CC1G_03802_Ccin ------------------------------------------------------------ AqueK117_Aque --------------------------------------------------PPQG-----H GSK_b_Smoe ------------------------------------------------------------ GSK_a-2_Smoe ------------------------------------------------------------ GSK_a-1_Smoe ------------------------------------------------------------ GK035_Glam ------------------------------------------------------------ GK036_Glam ------------------------------------------------------------ GSK3B_Hsap ---AA---SDAN------------------------------------------------ GSK3A_Hsap ---AL---TETP------------------------------------------------ Pk34A_Dmel ------------------------------------------------------------ sgg_Dmel ---GTA--AAAG----------------SGSGGATAGTGGASAGGPGSGNNSSSGGASGA gskt_Dmel ---AL---SKSPGPSGKALESPPGFLQHDLGNGDHVAVGTMPMEPLTLEQNHFAAESYAV GSK3B_Mmus ---AA---SDTN------------------------------------------------ GSK3A_Mmus ---AL---TEAQ------------------------------------------------ R03D7.5_Cele ------------------------------------------------------------ F21F3.2_Cele VAPSS---GEAP------------------------------------------------ C44H4.6_Cele ------------------------------------------------------------ C36B1.10_Cele ------------------------------------------------------------ RIM11_Scer ------------------------------------------------------------ MRK1_Scer ------------------------------------------------------------ MCK1_Scer ------------------------------------------------------------ Y106G6D.4_Cele CYNMT---ADLT------------------------------------------------ Y106G6E.1_Cele ------------------------------------------------------------ Y18D10A.5_Cele ------------------------------------------------------------ YOL128C_Scer ------------------------------------------------------------ GlkA_Ddis ---AITSSSNLK------------------------------------------------ GSK-3_Ddis ---ST---TNTT------------------------------------------------ 19912_Tthe ------------------------------------------------------------ 19923_Tthe ------------------------------------------------------------ 19924_Tthe ------------------------------------------------------------ 2636_Tthe ------------------------------------------------------------ 5825_Tthe -------------NFG-------------------------------------------- 7876_Tthe ------------------------------------------------------------ GSK3_Spur ------------------------------------------------------------ n1163_Tthe -------------NFG-------------------------------------------- CC1G_03802_Ccin ------------------------------------------------------------ AqueK117_Aque ---AS---NDVH------------------------------------------------ GSK_b_Smoe ------------------------------------------------------------ GSK_a-2_Smoe ------------------------------------------------------------ GSK_a-1_Smoe ------------------------------------------------------------ GK035_Glam ------------------------------------------------------------ GK036_Glam ------------------------------------------------------------ GSK3B_Hsap ------------------------------T----------------------------- GSK3A_Hsap ------------------------------T----------------------------- Pk34A_Dmel ------------------------------------------------------------ sgg_Dmel PSAVAAGGANAAVAGGAGGGGGAGAATAAAT----------------------------- gskt_Dmel GEDAEDNLEEDVGDENDYDYDDGGQCNSTYI----------------------------- GSK3B_Mmus ------------------------------A----------------------------- GSK3A_Mmus ------------------------------T----------------------------- R03D7.5_Cele ------------------------------------------------------------ F21F3.2_Cele ------------------------------SA----PGKRSES------NK--------- C44H4.6_Cele ------------------------------------------------------------ C36B1.10_Cele ------------------------------------------------------------ RIM11_Scer ------------------------------------------------------------ MRK1_Scer ------------------------------------------------------------ MCK1_Scer ------------------------------------------------------------ Y106G6D.4_Cele ------------------------------SLNNVKKGGCSSTRCILARNKCMTQSIGGT Y106G6E.1_Cele ------------------------------------------------------------ Y18D10A.5_Cele ------------------------------------------------------------ YOL128C_Scer ------------------------------------------------------------ GlkA_Ddis ------------------------------S----------------------------- GSK-3_Ddis ------------------------------S----------------------------- 19912_Tthe ------------------------------------------------------------ 19923_Tthe ------------------------------------------------------------ 19924_Tthe ------------------------------------------------------------ 2636_Tthe ------------------------------------------------------------ 5825_Tthe -----------------------G---SMMS----------------------------- 7876_Tthe ------------------------------------------------------------ GSK3_Spur ------------------------------------------------------------ n1163_Tthe -----------------------G---SMMS----------------------------- CC1G_03802_Ccin ------------------------------------------------------------ AqueK117_Aque ---------------------------TTVV----------------------------- GSK_b_Smoe ------------------------------------------------------------ GSK_a-2_Smoe ------------------------------------------------------------ GSK_a-1_Smoe ------------------------------------------------------------ GK035_Glam ------------------------------------------------------------ GK036_Glam ------------------------------------------------------------ GSK3B_Hsap --------------GD-------R--GQTNNAASASASNST GSK3A_Hsap --------------SS-------D--WQS-TDATPTLTNSS Pk34A_Dmel ----------------------------EDKYSVVEAFEAV sgg_Dmel --------------AT-------G--AIGATNAGGANVTDS gskt_Dmel ---SDD--------MD-------E--ASESDDDDFEEEDEN GSK3B_Mmus --------------GD-------R--GQTNNAASASASNST GSK3A_Mmus --------------GQ-------D--WQPSDATTATLASSS R03D7.5_Cele ---------------------TTE--KAEKESDSTNEELED F21F3.2_Cele --------TAAIAKKS-TMKSVMN--------APPPRQKPE C44H4.6_Cele ---------------------------------EGDKVECL C36B1.10_Cele ----------------------------DVTLTNESVEHST RIM11_Scer ------------------------------SVKKKLYPKSK MRK1_Scer ------------------------------HF-VSAPSSSL MCK1_Scer ------------------------------------TKVAE Y106G6D.4_Cele QIQFCCCNTGDLCNSKLTNMSFFE--KTKQRAKDFLDMLRG Y106G6E.1_Cele ----------------------------DTTLTNESVEQTS Y18D10A.5_Cele ---------------------------EVSTTSGDVAGPSA YOL128C_Scer --------------------------------------SLD GlkA_Ddis ---IDNSNNGKSSSSS-------NNIPSLNNSNNGVITNTI GSK-3_Ddis --------------ST-------T--NNTTTTTTTTTTSNH 19912_Tthe -----------------------------AGEDKNHFNQEY 19923_Tthe --------------------------------DNRSSDDSN 19924_Tthe ----------------------------------TEAQNQY 2636_Tthe --------------------------------------KYP 5825_Tthe --------------SS-------Q--SNPNMGNYQKNYQYH 7876_Tthe -----------------------------------SKKSYS GSK3_Spur -----------------------D---APETSTSATASSAT n1163_Tthe --------------SS-------Q--SNPNMGNYQKNYQYH CC1G_03802_Ccin --------------LD----------TFVPIPLEQMKISLD AqueK117_Aque --------------MT-------T--PDPTSELMGPNATGQ GSK_b_Smoe -----------------------------------VPFLAL GSK_a-2_Smoe -----------------------------------VPFLAL GSK_a-1_Smoe -----------------------------------VPFLAL GK035_Glam ---------------------------------------PQ GK036_Glam --------------------------------EQFNILSSH