CLUSTAL W (1.83) multiple sequence alignment Gdt1_Ddis MKKI--LLSIFFVVFLLI----GSECELIDTPPGYYNLKKIDKFQQFSKIQIERNNKTIY Gdt2_Ddis MNYI--LYILLILIIFSINNT-FSIGSFVYTPDGYYNLYRINKFENFSKIPTKANS---V Gdt4_Ddis MKLE--QRIFF-LICLVI-NS-FSNCSLLVAPDGYYNIYRENKIENILNLKPNG------ Gdt6_Ddis MINKISRFKILLLFIFIISLTCAQDEELISTPEGYYDLKRFKRFQHYKNIQPNE------ Gdt8_Ddis MINKI-LIKLITIIIFCFSFL-FAEEDLIRTPPGYYNLTRHKRYPHITEYQSS------- Gdt9_Ddis MKTF--LL-IFLLIC-VC-----KGITNITTPSIYFDLKKINRFQDYLNNGITPS----I * :: :. : :* *::: : .: . : Gdt1_Ddis SSSFHDLFYPDICEGTIQNI--PGSLYFGRSSFPGAQ-ES-SNLMITRGTKMKYRVGNG- Gdt2_Ddis NVEPHELYYPDICDSALKNK--N-SNEFSIDNFPGSPFLK-ANIKITKGSNMTLDPLLS- Gdt4_Ddis N-KSQDSYYPDVCSKAVKNK--EGVKSFILSSFPLSTKEY-ANVIVTKGSHMTLGDGEYH Gdt6_Ddis EAGYTDLYYPDVCKNAIRNR--DGAPTFNQRSFPGYTGVF-DTLLITKGTNMTLDSTGFL Gdt8_Ddis --QDTDLYYPDVCRNALRNDIIPGVDEFFPFLFPGFNSDGPNSIYIQKNSSLLFKSESLG Gdt9_Ddis NLTFHDFYYPDVCVNTIKNI--DGSTNFVKSSFLNAPTNF-ANLYITKGSKMTVKPNQ-- : :***:* :::* * * .: : :.: : Gdt1_Ddis -GIPIY-KINVLCIEGTLEIPE---GISFFNVGALFILPGGVLNSKS-SIRFTDLDP--- Gdt2_Ddis -IHPS--YINILCIEGSFTAGS----QQTLTLGGIIVLPGGNFHCNNCVLQFVDLSS--- Gdt4_Ddis QIFNINRFLNIVCVEGSLVFST----KDVVYMSALVILPGGNFECIDCTIKFRDLYP--- Gdt6_Ddis TGLGIWS-LLTLCVEGNLTVLYNPDEFSFVPVHRLVILPGGTITSHANSFLFWDTYQVDE Gdt8_Ddis T---TYN-FVAVCVEGSFTVKG----SMFFTINSLIILPGGRFESE-AGIEFYDENDPLH Gdt9_Ddis -ILGA--FINILCIEGSLEVPV---GVFPFFIGALVILPGGNFKSES-SFRFMNL----- : :*:**.: . : :.:**** : . : * : Gdt1_Ddis -------YNSKMDPFNFFPGMMVLGGSLSLIGEKKRIFQATRIDDYQLQIED-FKKIGSL Gdt2_Ddis -------TIIKIDPFGFLPGILSLGGSISLIGSQRILYSAKPIEDNVLEVND-ISTLDPF Gdt4_Ddis -------TNSLIDPFGFLPGIITLGGSLSLLGKQKTVYSAVLIDENILEVQD-ISSLDI- Gdt6_Ddis NFQEELNKRVKIDPFNFFPGLLVLGGNLNLFGNSQLTYTAKRLNDTTLELSTPFLNMKFL Gdt8_Ddis ---IYNNPDFPKDPFGFFPGILVLGGTISVVAKESLVYRADRISNSSIEISPPFSPMNKI Gdt9_Ddis -------VNSKIDPLNFFPGILTLGGSLSILGPKSIKYSANRLGDFQFQLLE-LIDPNSF **:.*:**:: ***.:.:.. . : * : : ::: : Gdt1_Ddis TNNIYLGSKVTIYSQQISEGQTCSFSFGASNDKINLTSSSSSSLRGTNCLPISKNDKNII Gdt2_Ddis N-----GFNVSIVSDSFPNVRTSRFTYNKNKLEMQD-------------LTIPTTDLNIK Gdt4_Ddis ----FNGYSLFIFSESFPLGKASTFTFNSNQIKVLE-------------IKIPKTDKSIR Gdt6_Ddis ----WNKYIITIFTESIPQGDDCLFNMDSDKRTFYLIKT-----NYGTCNPLRETDKLMK Gdt8_Ddis -----N-QTIRIFTELYPLGFYCSFSSDLERKILSLL----------DCLPISENDKIIR Gdt9_Ddis NS----DYKANIYSESFVTGQQCDFVSITNGYTLTV----------GGCQGVPSTDVNIY * :: . * . . : .* : Gdt1_Ddis VHFNCKY-LLGGSSE-S-FI--DSTSTVGSSIYITGDSQVQIENFTLDSIGKTTNKLYND Gdt2_Ddis LFFNDS------GSL-K-FG--GISTRTKSSIYITGDTKLHIENYLLDSIGKTSNKEYDD Gdt4_Ddis VFFYS-RF-S-------TF-----STSTTASIHITGNSNVHIENFYIDSFGRTTNDQYSD Gdt6_Ddis VVISYNRYEDNYSSYISLFSDYYGFEPNEASIFITGDSNVYIENYLIKNLGKTKNNAYSD Gdt8_Ddis VLIEVD-RDQNVSPT-N-IL--KKGKTTKGSIYITGDSNVYFKNMFFKNLGFTTNEPYND Gdt9_Ddis IFFATVD-----YDC-T-FI--DSDSEVPASIYISGDTNVHIENFFLNSLGKTTNANYND : : : .**.*:*:::: ::* :..:* *.* *.* Gdt1_Ddis TKLIFSNDKPNQVIDIIKGENQRFRNSLYIEFSNSVVIKGCAIIDRVKESRAPLIFVSSN Gdt2_Ddis TKLTFSSDNPNNVTDIIIGKNQRFRNSLYIEFSNSVTIKNSVIIGNTGSSRSSLVFFQSN Gdt4_Ddis TELIFSQDDPNLITGFINGSNQRFRSSLYIEHSNNVTIKNSVILENRGETRSPLIFFGSN Gdt6_Ddis TKLIFSPNNTSEVIGFINGTNQRFRSSLYIEFSNNVIIKNCVIIESSSETRSPLVFFGSN Gdt8_Ddis TKLIFSPNDPNQVTDIIMGTNQRFRSSLYIEFSKNVTIDGCAFFED-NLTRSPLVLFDSN Gdt9_Ddis TILIFSPTDDTNVTDIIIGTNQRYRNSLFVEFSNNVTLRNNFIRES-IESRSPLMFFASS * * ** . . : .:* * ***:*.**::*.*:.* : . : :*:.*::. *. Gdt1_Ddis VSLSESLIVSKSGSNLIAQYGTEFIKSKLNHYFLIPPLPQPFGLN--------------- Gdt2_Ddis VNISGNLIVGTAGSSMIAQYGTEYIESSNNYFSLVLPNEFP------------------- Gdt4_Ddis VNISGNIISSKSGSSLIAQYGTENIQSTNNYYSLSLPLLKSL------------------ Gdt6_Ddis VYLSDNLISSKSGSSLIAQYGTENIQSINNFYFQKGVSHQTA------------------ Gdt8_Ddis VIISNSLISSKSGSNIIAQYGTESIQSSNNSYILVKIDTASLDVDQNNNNNNNNNNNNNN Gdt9_Ddis PILEGNLVVSNSGSSVIAQFGTEFIQSTNNSYFLEPPT-QPV------------------ :. .:: ..:**.:***:*** *:* * : . Gdt1_Ddis ---------------SPINFPSPFSMDYGFEGNGIYSLSPNVQSINDTFISQLIALNFNF Gdt2_Ddis --------------------TSPAFMDYGHEGNGIYSLSPNIFSTNDIFNGQKILYNFNF Gdt4_Ddis -----------------N--STLDSMDYGNEGNGIFSISPKINSINDIFNGQIIAINHII Gdt6_Ddis -----------------SQILNPINMDFGNEGNGIYSVSPNLLSSDDFFIGQNYSITFNF Gdt8_Ddis NNNNNNNNNNNNNNNNNNNNNNNNNMDYGNQGNGIYSISPNINSNGDSFFGQQYAFNYYF Gdt9_Ddis -------------------IPNDNNMDYGTEGNGIYSLSPIVSFTTDVFVGQLISINFNF . **:* :****:*:** : * * .* .. : Gdt1_Ddis IGNRSIITGFDNDCYSPCTNTSILFSNLIQYPVDFKINNSTYFYKLNNNNNDNNNNTNNF Gdt2_Ddis IS-RENVTGFDKDCFAPCDINSIVVPSLSQEPIDFSKNLV-------------------- Gdt4_Ddis LSDRSSITGFDKDCYSPCYNDSIRVSSKVQHSVEFKITGSTFIS---------------- Gdt6_Ddis IANRSKITGFDQDCYAPCFSDSINFSNKIQYPVDFKIFNPKFLP---------------- Gdt8_Ddis ISKNSVNSNQDNS------------SLLNSKPIELIIIDSSFNP---------------- Gdt9_Ddis IANRSLVTGFNYDCFAPCYPGSPIISNLVQHSVDFNIIKPTFSYSHGNTTSSTT------ :. .. :. : . . . .::: Gdt1_Ddis NLLNINNENNNNDDNNNNNNSQNHYLLNINNNGNSPGRFFTIKDLVA-SDTVSAYLPNSA Gdt2_Ddis --------------NPISINP-VDYFLIVNSDEELKNTFFTIKDSTI-SSKIIVNLKGSG Gdt4_Ddis ---------------SS-NYSESSFLFRISETGSKQSSFYKIINSNL-SYPISVLLENNA Gdt6_Ddis ---------------TN-NTNSDWYILNINDNGNQPGTYYTVKNLTT-LDPVQFSLDNSA Gdt8_Ddis ---------------TNSNGSLNKYLLNINSDGNKTISTYLVCNS--------------- Gdt9_Ddis -------------TSSTTTNTNSHFLLNVNDNGNEPSSYYSFNQLSIASEAIKVNLPIGT ::: :.. . : . : Gdt1_Ddis LVFNNLNATENFSFNGTVSRLDFINSSFNTN--LTSTQKFFDETTTTVTNFQNTYIYGS- Gdt2_Ddis LVLKNIIGVNNFKLTGQVKRLDIYDSFFGSS--TTPSLGDNG-IKSSAVIIKNSSFYID- Gdt4_Ddis FILDNVYGFGNFTINGLIKRLDIINSTLDPS--VTSSISL-SN-FSKAISIQNSFMDYRS Gdt6_Ddis LSFLGLEASENFKMNGNAKRLDIVNSIISSKA-LTNQQQIISKVSSSAISFKNSYIYSKL Gdt8_Ddis ------------------------------------------------------------ Gdt9_Ddis LGIGNLFATNNFKIDGALERLDILNSIFNLPPPISNNFSQSGILLSTTTSMLNSYVFVSI Gdt1_Ddis -PETTEPPEKVFGSSITPIYYFSKSVLDSLKVETVYPNEPHKMFFNSSVSLSVKLNNMGL Gdt2_Ddis -D-FQLQNNQIYGSSIVPYLYELLNVDEFILVDSIFPTSQYQIPVGGKLDLIVKLVIIS- Gdt4_Ddis F---QKQNNQIYGSIITPYLYYFENTMNLIKVSKMYPNVNHQILAGTVLNMGIEIIIIA- Gdt6_Ddis GQQITPIDNQIYGSLITPFYYNDSDILNQVKILSIFPNVPFQIVSGSILNVSINLQIIS- Gdt8_Ddis ------------------------------------------------------------ Gdt9_Ddis GSEPTRIESQIYGSTITPYYYNNIETLDLFQIQSIFPSVQYQIIKNSTINITINITTTTT Gdt1_Ddis ------KTPIICIFSSNG-ME----------SKEVQYNPISTKCSFLYVSEKLGNHNIRV Gdt2_Ddis ----PVISRITCELESDNETI----------TSSAISESVNKECKFPLTFKNDGSVNLKV Gdt4_Ddis ----PLFGKMDCIFEDES-GI-----------QTIPFNKSSNSCVLPYLFKNEGSFNVRV Gdt6_Ddis ------TADISCTFSSDNSTF----------STTILVNPSDGSCVLPLVFEKEGYFNLKV Gdt8_Ddis ------------------------------------------------------------ Gdt9_Ddis TTTTPTTNNVVCSFTSIVNQQSSVTNEISINETLIQMDPILNNCVFPLSIDQEGSLKLRV Gdt1_Ddis TIKNEYS-KDSSYYFIIDFPIITVYGQSLFNAGWQMIDPTSTTIIPTPTPTSTSTSTSTS Gdt2_Ddis TVKLKNV-GDSEIMYIINFPKITIFSNYSFYSGWSMENSTEN------------------ Gdt4_Ddis TLSLTKS-LDN-IIFQVYFPMVTVFNIYSFYSGWAMIDSNIE------------------ Gdt6_Ddis TLKISTS-KD--YYYIVDFPKITVYNEYLFYSGWVMIDSSTD------------------ Gdt8_Ddis --------------------------IIEYYSGWLMDNLNSN------------------ Gdt9_Ddis TIKNQNSTLENQYYYIIDFPEITIFQSFQFYTGIKFIDVQSSSSSSQ--------QTSSF : :* : : Gdt1_Ddis TPTTTNNNQLVNDNNNKINELDGLKFQGGCIK-----TLGCQLSSNAKYVGGLPNVTASS Gdt2_Ddis ----------------GIISVDGNSFKKGCSISSNDNSNNCTISNNIKYITNLPKLNISN Gdt4_Ddis ----------------KEIIIDGNIFKKGCQQQ---VLGNCTISTNSKLITGLPSVTESD Gdt6_Ddis -----------------EFLFEGKIFKSGCQQQ---VLGNCTISTNSKFINGLPNVTETD Gdt8_Ddis ----------------QQISFEGNLFQNGCNK----VDGNCTISQNSKYSTDLPKVANQT Gdt9_Ddis SPTTTTFLNLL------STTENSNGFLNGCQI-----SNQCTLSNNVKYVSSLPNVTNSP :. * ** * :* * * .**.: Gdt1_Ddis T------LNSLFSWGITSDVQYDPVIIDLFINKSIATLQVQLFFTFYKPIDQYSSPLSVS Gdt2_Ddis D------LNELFLNGITSINSNELVTITTRIDSETKYYQIQLFFI-HQPIDDQPTPLSIY Gdt4_Ddis K------LNRLFSSGITSINPYEPVTITIPIDKESKKNQIQLFFT-HQPIDIETSLLSIY Gdt6_Ddis E------LNRLFSSGITSINPYEPVTITIPIDKESKKNQIQLFFT-HQPIDIEYSLLSIY Gdt8_Ddis KFDEIVQLDKLFSNGITSINPNEKVIISTKINSKIHYYQIQLFFT-HLPIDDQPTPLSIY Gdt9_Ddis D------F-QLFQSGITPIIPYDPVVINLGIEK-NKTFQFQLFFTFYQPIDQYSSPLSIF : ** ***. : * * *:. *.**** : *** : **: Gdt1_Ddis IQKNPVLVMEPFAGD-QPFSKNLTFVYNNTQSLDFLNISFTSRGDIYLTSLAIFSVSDSL Gdt2_Ddis IENQPVFLLEPLESNSAPIFKNLTFNFDNINSLENINISFATRGNTYLTSMAIYSSLVIE Gdt4_Ddis VENQPIFLLEPLQSNLDSTFKNLTFHYENSKSLEKIKITFITRGDIYLTSTAIYSSTNQP Gdt6_Ddis VENQPIFLLEQLQSGLGSTFKNLTFNYENSKSLEIINISFTTRGDIYLTSMAVYSSAIPI Gdt8_Ddis IENQPVFLLEPIKST-FPTFNNFTFKFENKNSLDKINIAFTTRGDIYLTSMATYSSIVVE Gdt9_Ddis IQSEPYLLLDPLID--APNFKNFTFFYDNLN-QDSIEISFISRGDIYLTSMAIYSLDLVS ::.:* :::: : . . :*:** ::* : : ::*:* :**: **** * :* Gdt1_Ddis PQIIDPI----------T----------PT------LLPIESV--K-ASKPAILAIVLSI Gdt2_Ddis YP-----------------------------------------I-P-VEKINLLPIIVPI Gdt4_Ddis IY---------------------------------------NEVIGINEQLNILAIVLPI Gdt6_Ddis IVTPTPTSTTSTPTPTSTTTSTPIPTTTPTT----------TPKTSKTTSKNKLKIALPI Gdt8_Ddis PPTETPTET---PTETPTETPTDTPTQTPTQTPILTSKPITQISVDRNE-NLELKIALPI Gdt9_Ddis YESSDSSS---SSSNSSS----------ST------GNGIGDIV-NNEDNHKKLVIALSV * * :.: Gdt1_Ddis VLGSLAL--SII--TILIVKHRK-RLSQFLSKSN-K--DIEYAQ-----NNEIEIK-VLP Gdt2_Ddis CVTVLVL-LSILI-VFFGARYYKHKKRRRLEIAV-F--GVELYSKKPS-NNKSPVP-STP Gdt4_Ddis TISLFAA-ASILA-GYLVIKKYK-KPNMYYNRNTNGNIGMKVFSTKFKRRPKKVIPLSIP Gdt6_Ddis CLFALLVAVGVLI-CF-IFRKKK-QKKQKLDNNM-ED-GSEMSSIKIK------------ Gdt8_Ddis CLSLALL-IGIII-MICIFKKVQ--SNSKLKKDD--D-ENEMATIKEG--NKSIIV-SQP Gdt9_Ddis SIPVAAL-LVILCFGIFICYNNN-KKNKN-ETKG-K--DIETNT------DKK------- : :: : . : Gdt1_Ddis KITSHSSYPSISILDTISSDSIFNNQIP----KNNNRY----KFKN-------------- Gdt2_Ddis LIINSNQEQSS------------SNHIS---ITVNRNS----DIQT-------------- Gdt4_Ddis LSTNRITKKSLQSLDSMAENPVILLSIPELEKANEPEFNPEKTFLQESELLDLPTPKVEP Gdt6_Ddis -------------------------------KENYN------------------------ Gdt8_Ddis --------------------PTVIE------EK--------------------------- Gdt9_Ddis -----------------------DDENE----NENCKF----QFKD-------------- Gdt1_Ddis -------------------------------------QSLNNNNYFNNN--------NNN Gdt2_Ddis -------------------------------------QSENNNLEPTTV--------ETT Gdt4_Ddis EEPRINIVPLPRFPTVYKKEDNDKLLKELNITXPITSENIESFFEVDVGLPSLIIKNESE Gdt6_Ddis ---------------------------------SF------------------------- Gdt8_Ddis --PQDNS----------KPDDQKLIERDQQINNPILK----------------------- Gdt9_Ddis -------------------------------------EFLTNPNEINIQLKKLMINKSST Gdt1_Ddis NNSNNNNSNNIIYSNCNSNYSNSNSNNNNNNNNSNSNNNSNSNSNININSNSNSNSNSNS Gdt2_Ddis TTTTTTAAGAILQTNVTLEMENLE-IK--PIINNNEPFFEDY-SDEYDDSSDGAELNEDD Gdt4_Ddis IILQEIDYIETGEIQ----------------------------------EMEGSFLEDKS Gdt6_Ddis ------------------------------------------------------------ Gdt8_Ddis ------------------------------------------------------------ Gdt9_Ddis LPPQSTISIDTSPSSENTTFTESLTPKKSATVNGEIDFSRNS-TNESTVSNSSSENNSDN Gdt1_Ddis NG-------------------------------NNNYQIYSNKLES-------------- Gdt2_Ddis VEDYINIIRGGNIKIEAEGELFVRQFER-NTFDQEFFEYKKSKIPS---PHLVPSLAHGD Gdt4_Ddis TDTTVIVTKSDGLPKFFQTKVFSKRFNDISKFDNDFFDLKEYIVEHQEESFEIPFMTSED Gdt6_Ddis -----------------------NKFKESTVFKNDD------------------------ Gdt8_Ddis -------------------------IREYPSLKDIE------------------------ Gdt9_Ddis NN-------------------------------NNNNKCKKEKLSS-------------- : Gdt1_Ddis -----------FKIDEISNDTIPIINSTFPDEFQTLEFQKLAFEILKREKR---LD-FSF Gdt2_Ddis FI-ENPLNIIDILLDPVTNE------------------IPLEHYLKTYKNRN--GQSGKY Gdt4_Ddis EVDETKINIIDFLLSPKSNK------------------VALNMYLKSFQNRNHKLCYGKY Gdt6_Ddis --------------------------------------------FK---NYSNPTETTIY Gdt8_Ddis --------------------------------------------LS---NE--ETKSPQY Gdt9_Ddis -----------FPTIPGTNL------------------TNIPLNLVGRKSRN--PE-DKY : . : Gdt1_Ddis RTT-NDILTCCALSDFKDF--SNFPLRFNQSIITFGL-INGKAKLGETYYDTLSITNDST Gdt2_Ddis RTN-TQTHVLIADTIFQHCNDPDLPVSVSPYICDFGM-NGRKSDLGEVCHDTITFKNKLS Gdt4_Ddis GSNKNSILVIEGTSYYYDCTDVRLPISTPRSNLNFGITDGNKCIVDRKYRERLQYINVYS Gdt6_Ddis -STSDSLLNF-VGSDFLNYSDPNIPLSFSKNILEFGL-KGSKCDINTFLSDSLRITNNSN Gdt8_Ddis GS-LNSFSTL-QFSRQYDYGSEEFPFQFNKQVLEFNL-NGRKCMNDEVINDSLMIHNKSE Gdt9_Ddis RTN-NDILVCLQESHYFKPDDPSIPIEFSESVLDFG--RGSKCLIDETYIYTISVKNKST : . : . :*. *. . *. . : * Gdt1_Ddis IRFTAFLILPMDNHSATFTS-----DHSSFDLGPGETFSIKFSITLHCTTRFFENFSIQI Gdt2_Ddis EPLYALFLFPEGDDSSITSS-----PFQSIELKPNVETSISLSVTLFSTTKYNEKVIVRF Gdt4_Ddis EPFRIYTLFPDSNDNVTITT-----SECCKEIDPFGSLDVDIFVTLKTTTKFNEKVTIRY Gdt6_Ddis IILCICTVLPRN-DSGEVNV-----SPDSFELDPNQSREIEFSLKLNCTTRFFERFAIEA Gdt8_Ddis ITYLVNIIFPQNIETGCVSILNVEIFNESFELLPHCTTEVKFSLTLTCTTKFLENFAVLV Gdt9_Ddis TDYNILLILPIDNNTGTIST-----DTQYFQINAGESKPISFSISLNCTTKYFEKIGVSI ::* . .. . :: . :.: :.* **:: *.. : Gdt1_Ddis NSNNIK-EMYTLLKIKVESESSTRLDFNDIHFQELIEKYSWE--ILYRGTVGDKNALLKL Gdt2_Ddis ETLDVKQSWSTFVFLRLESELTNIIDFNEIIIKNYISEGTFG--IVYRGIWRSSPVAVKL Gdt4_Ddis ETDDKELAFSTFVYLNLESQVSSKIDFDEIVLEKYLSEGSFG--VVYSAIWRSSSVAVKL Gdt6_Ddis RHTHSFKSIHTHLFIHVESKISSKLDIKEIEVKELISQNNLS--TVNIANYRGLQVVLRK Gdt8_Ddis EAQGS--KCHTFLSVHVESETSLKLDYKEIKTEQLIASYLPSKVYVFKGYYRDLAVAVKK Gdt9_Ddis EELN----YHTFICVHMESELSTRLDFSELDFDEICGQGTYG--MVYKGKWRSQVVAIKM . * : :.:**: : :* .:: .: . : . . . :: Gdt1_Ddis IKL--KTKNC--------EEAYRELNIISRLKHQNILPLIGCVISKDYLCLAFEYPPLGS Gdt2_Ddis LKN--EYVDH--------DEIEKEISLLERLRHPNILLYVGRFIFSGIHGIVTDYCSKGC Gdt4_Ddis FKH--HY-SK--------DEIDKETSILSKIKHPNIVSFIGSLNFLNTYGIVIDYHPRGS Gdt6_Ddis IKT--HSANYTKTYSQAIKKFYTEMDILSKLKNKNIVSFIGCTHDSSHLWIVTEYAPLGS Gdt8_Ddis FAISDNSKSF--------EKIKNEVQILSKVNNINVVRYIGSAQNISHVCIVTEYAKEGS Gdt9_Ddis MRV--GTVNC--------DEVYREMDIMGKIRHQNVISFIGCVVSLEHLCIVTEFSPIGS : . .: * .:: ::.: *:: :* :. :: *. Gdt1_Ddis LDYIISK----------------------------KKLKMSITQKIRILIDVAKGCKFLQ Gdt2_Ddis LSKYIHE----------------------------NKYKITIIQKIRILIDISKACAYLH Gdt4_Ddis LNYYTRN----------------------------QNIKLSMVQNIRISLDISRACSFLH Gdt6_Ddis LSSLIHQ----------------------------KKEKLSLIQKVKLMLDTAKGCEFLH Gdt8_Ddis LGSLIHD----------------------------SKIKLSFIQKVKFMLDAAKGFTFLH Gdt9_Ddis LGDLIHGDNNQKKSNTNTITNTITNTNTNTNTSTSTSTKLTVKQKLRIAIDIARGCQFLH *. . *::. *:::: :* ::. :*: Gdt1_Ddis QSSIIQKTLRARNIFLYDTNENAEVCAKVLDLTSSKTIKGLACNNYIERVDTPINLTREI Gdt2_Ddis RNGITHRDLKPENILITSLNPKSLVCAKVSDFGTSKETNERYNLQ-TR-RGTVAYMSNEI Gdt4_Ddis KNGIIHRDLKPDNVLIVSFDPDSSICAKISDFGTCREINGKHELN-SK-AGTTRYMSPEI Gdt6_Ddis SNDITNCNIKSNNLLLFSTMEKDDVCVKISDFGIKKFEVQNQN-------------EKEI Gdt8_Ddis ASEIVHGDIKPDNLLVFSK-EISGVCVKICDFGNSEELGEKESKS-KP-DSTMNYLPNEV Gdt9_Ddis QCGIIHRDLKPDNVLVFDINHNAPVCAKISDFGTSKETNEFSNKN-TNCVGTPIYMSNEI * : ::. *::: . :*.*: *: . *: Gdt1_Ddis SIIRDPKQNNDFNNSNNSNNNNNNNNNNNNNNNNNSNNSNNSSSLKYNIHSFAVLSYELL Gdt2_Ddis L-------------------------------------SQGSYTKSTDIYSFGMLCYELF Gdt4_Ddis L-------------------------------------EGLPYTYSTDVYSFAILFFELL Gdt6_Ddis F-------------------------------------KDEKDQKLIDVYEFGITFYETM Gdt8_Ddis F-------------------------------------DGEGYQKSADVYAFGVSLYEVM Gdt9_Ddis L-------------------------------------EKKTYDNSTDVYSFAVLFYEMM . ::: *.: :* : Gdt1_Ddis IDEILVGDT--------RKFGQEKPSIGLDKI-DPNIKNFIHKCWNPI--DGFTFNEILK Gdt2_Ddis SERIPYYSEP-HWRIRELVLKNERPSLDQEIFKDTDISDIVTRCWSKNPSQRPTFDYLSK Gdt4_Ddis SGRVPFREIP-KREIPRFVRLGTRPRLDQDVFADNDISLILLACWNPNPRGRPTFDTLID Gdt6_Ddis LEETPE-------NLSNLILEGERPTLDLEKL-DADIRNIIERCWNQN--KRSTFSEISI Gdt8_Ddis VEKIPFHEIC-YNDIPNRVQDGFRPTADLDTI-DDDIRKIIECCWIKEKSKRPSFSEISL Gdt9_Ddis IEEVPFSEIDEKWEIPSKVISGWRPTKGLNSL-DRDIKNLINICWAPH--SLPSFDEIVF . :* . : : * :* :: ** :*. : Gdt1_Ddis TLKDFIES---------------------------------------------------- Gdt2_Ddis YLKHLLKKYDINNIIYDKDKKNKKKNKNNNNNNNNNNNNNNNNNNNNNNNDDHDDNNNNI Gdt4_Ddis LLEKLLKKYKE------------------------------------------------- Gdt6_Ddis SLKEKYTKLL-------------------------------------------------- Gdt8_Ddis HLEIKFSKLLHQ-----M----NESEE--------------------------------- Gdt9_Ddis SLVKIFKR---------------------------------------------------- * Gdt1_Ddis -----------------------------------LN Gdt2_Ddis NDSDCDNNKNNNNNNNNNNNNNNNNNNNNNNNNNNNN Gdt4_Ddis --------------------------RAKRNKKNQNQ Gdt6_Ddis ---------------------------EKNNELIQEN Gdt8_Ddis -----------------STSNHNTNSKTKEDKDLDEN Gdt9_Ddis -----------------------------------FN :