CLUSTAL W (1.83) multiple sequence alignment LMR3_Hsap MPAPGA-----LILLAAVSASG-------------------------------------- LMR2_Hsap MPGPPALRRRLLLLLLVLLIAG-S------------------------------------ LMR1_Hsap MS-------------------S-SFFNPS--------------------------F---- LMR3_Mmus MPAPGA-----LILLAAVSASG-------------------------------------- LMR2_Mmus MPGPPASPPPPMLLLLLLLTVG-C------------------------------------ LMR1_Mmus ML----------IALLALAMSS-SFFNPS--------------------------F---- LMR_Spur MARLTFST-GTCALLVCAFISG-------------------------------------- AqueK333_Aque MNTNVS-----IGLLI-LSIACLSLGQPICQAPQNTLYSNTDLNVFSNCQQINGSLVMGD * LMR3_Hsap ------------------------------------------------------------ LMR2_Hsap ------------------------------------------------------------ LMR1_Hsap ------------------------------------------------------------ LMR3_Mmus ------------------------------------------------------------ LMR2_Mmus ------------------------------------------------------------ LMR1_Mmus ------------------------------------------------------------ LMR_Spur ------------------------------------------------------------ AqueK333_Aque QFCTRSCTITDFSALSNLQAITGSFIVQCCHTLSVFPNIPRLTQIQGALRIYYNTGLRSI LMR3_Hsap ------------------------------------------------------------ LMR2_Hsap ------------------------------------------------------------ LMR1_Hsap ------------------------------------------------------------ LMR3_Mmus ------------------------------------------------------------ LMR2_Mmus ------------------------------------------------------------ LMR1_Mmus ------------------------------------------------------------ LMR_Spur ------------------------------------------------------------ AqueK333_Aque AGLILGTVGSLEIAQNQLLHSIDVLQINRISNYVSISYNPSLGSIRGLTNLISIEGNQLV LMR3_Hsap ------------------------------------------------------------ LMR2_Hsap ------------------------------------------------------------ LMR1_Hsap ------------------------------------------------------------ LMR3_Mmus ------------------------------------------------------------ LMR2_Mmus ------------------------------------------------------------ LMR1_Mmus ------------------------------------------------------------ LMR_Spur ------------------------------------------------------------ AqueK333_Aque NGHALRILYNPILTDISGFQSLDTINYGTVHIEGNTQLCYSGYPRWSYGSYESRYSTGDK LMR3_Hsap ---------------------------------------------------CLA------ LMR2_Hsap ---------------------------------------------------AGA------ LMR1_Hsap ---------------------------------------------------AFS------ LMR3_Mmus ---------------------------------------------------CLA------ LMR2_Mmus ---------------------------------------------------ARA------ LMR1_Mmus ---------------------------------------------------AFS------ LMR_Spur ---------------------------------------------------SLA------ AqueK333_Aque GIDWRSKLNTQYSWQFTWGGNGVPTLNIQGNGNYSTCASTTCHSSCQSGVGCLGPSNPGL . . LMR3_Hsap -----------------SPAH--PDG---FALGRAPLA-PPYAVVLISCSGLLAFIFLLL LMR2_Hsap -----------------APLP--QTG---AGE-APPAAEVSSSFVILCVCSLIILIVLIA LMR1_Hsap -----------------SHFD--PDG---APLSELSWP-SSLAVVAVSFSGLFAVIVLML LMR3_Mmus -----------------SPAH--PDG---FALSRAPLA-PPYAVVLISCSGLLAFIFLLL LMR2_Mmus -----------------APLP--QTG---AGE-VP-VVEVPSLFVILSVCSLLILIVLIA LMR1_Mmus -----------------SHFD--PDG---APLSELSWS-SSLAVVAVSFSGIFTVVILML LMR_Spur -----------------APLT----G---SE-DQEPFS--LLVSVSLSLASLLILVLAVV AqueK333_Aque CGSCYQTSTINSCDEVSAPETVTQNCVTLWPPTELPFS--AIFGLLVACGGTLIIIVLIA : : :. . : .:. : LMR3_Hsap TCL-CCKRGDVGFKEFENPEGE----------DCSGEYTPPAEETSSSQ----------- LMR2_Hsap NCVSCCKDPEIDFKEFEDNFDD----------E--IDFTPPAEDTPSVQ----------- LMR1_Hsap ACL-CCKKGGIGFKEFENAEGD----------EYAADLAQ-GSPATAAQ----------- LMR3_Mmus TCL-CCKRGDVRFKEFENPEGE----------DCSGEYTPPAEETSSSQ----------- LMR2_Mmus NCVSCCKDPEIDFKEFEDNFDD----------E--IDFTPPAEDTPSIQ----------- LMR1_Mmus ACL-CCKKGGIGFKEFENAEGD----------EYVADFSEQGSPAAAAQ----------- LMR_Spur GCA-CCFGKSSLLKYEESVEYEERNPNQSHTNDGFADFSPPTQSTPSFPPGGV------- AqueK333_Aque LCI-VVYKIRKKCNGDEESKG-NYNVNE-RNLESGS-SYQPSRNTYSSGSRSKLHHSNNE * : *. : : : LMR3_Hsap --------------SLPDVYILPLAEVSLPMPAP---------------QPSH------- LMR2_Hsap --------------SPAEVFTLSVPNISLPAPS----------------QFQP------- LMR1_Hsap --------------NGPDVYVLPLTEVSLPMAK----------------QPGR------- LMR3_Mmus --------------SLPDVYILPLAEVSLPMPAP---------------QPPH------- LMR2_Mmus --------------SPAEVFTLSVPNISLPAPS----------------QFQA------- LMR1_Mmus --------------TGPDVYVLPLTEVSLPMAK----------------QPGR------- LMR_Spur ------SETVSIE-ALPDLSSRLQTSHGLPQVS----------------TALSSDVG--- AqueK333_Aque MEMRETSPQVSSYNPADDDYTYSQVVKKTPTAQETRKQEEPIVHKPTYEERQKEKEESEE : * LMR3_Hsap ------------S-D-MTT-PLGLSRQHLSYLQEIGSGWFGKVILGEI---FSDYTPAQV LMR2_Hsap ------------SVE-GLK-S-QVARHSLNYIQEIGNGWFGKVLLGEI---YTGTSVARV LMR1_Hsap ------------SVQ-LLK-STDVGRHSLLYLKEIGRGWFGKVFLGEV---NSGISSAQV LMR3_Mmus ------------S-D-IST-PLGLSRQHLSYLQEIGSGWFGKVILGEV---FSDYSPAQV LMR2_Mmus ------------SVE-GLK-S-QVARHSLNYIQEIGSGWFGKVLLGET---YTGTSVARV LMR1_Mmus ------------SVQ-LLK-STDLGRHSLLYLKEIGHGWFGKVFLGEV---HSGVSGTQV LMR_Spur --------NQDGELKHLKSPRFVFPRDQLNYVDELGNGWFGKVLQGEAHRLHPGMRKTRV AqueK333_Aque EEEEEEESEEEPRDN-FME-EYEMPSRKIQLMKEIGEGSFGKVFKGLASDVLPNERVTDV . . : :.*:* * ****: * .. : * LMR3_Hsap VVKELRASAGPLEQRKFISEAQPYRSLQHPNVLQCLGLCVETLPFLLIMEFCQLGDLKRY LMR2_Hsap IVKELKASANPKEQDTFLKNGEPYYILQHPNILQCVGQCVEAIPYLLVFEFCDLGDLKAY LMR1_Hsap VVKELQASASVQEQMQFLEEVQPYRALKHSNLLQCLAQCAEVTPYLLVMEFCPLGDLKGY LMR3_Mmus VVKELRASAGPLEQRKFISEAQPYRSLQHPNVLQCLGVCVETLPFLLIMEFCQLGDLKRY LMR2_Mmus IVKELKVSASPKEQDTFLKSGEPYYILQHPNVLQCVGQCVEAIPYLLVFEFCDLGDLKAY LMR1_Mmus VVKELKVSASVQEQMQFLEEAQPYRALQHSNLLQCLAQCAEVTPYLLVMEFCPLGDLKGY LMR_Spur VIKQLRDTSTPDEQLLFLQEVQPYREVNHPNVLMLLGQCIESIPLLLVLEYAPYGDLKNY AqueK333_Aque IVKQSHRNATEDELEDFLEPAEKMRNLKHDNVLHLLGVCVDSDNMLIVLEDCANGNFKTF ::*: : .: * *:. : ::* *:* :. * : *:::* . *::* : LMR3_Hsap LRAQRPPEGLSPELPPRDLRTLQRMGLEIARGLAHLHSHNYVHSDLALRNCLLTSDLTVR LMR2_Hsap LRSEQEHMRGDS-----QTMLLQRMACEVAAGLAAMHKLHFLHSDLALRNCFLTSDLNVK LMR1_Hsap LRSCRVAESMAP-----DPRTLQRMACEVACGVLHLHRNNFVHSDLALRNCLLTADLTVK LMR3_Mmus LRAQRPPEGMSPELPPRDLRTLQRMGLEIARGLAHLHSHNYVHSDLALRNCLLTSDLTVR LMR2_Mmus LHNEQEHVRGDS-----QTMLLQRMACEIAAGLAAMHKLHFLHSDLALRNCYLTSDLNVK LMR1_Mmus LRSCRVTESMAP-----DPLTLQRMACEVACGVLHLHRHNYVHSDLALRNCLLTADLTVK LMR_Spur LRKNRGMVAQMA-----QKDVQLRMAHDIISGLLWLHQADFIHIDFAARNCQVCADASVK AqueK333_Aque LINKRSHMEMMK-----KDGSLLQMIIEMAEGLNYLHENSITHSDFAARNCLVCANNRIK * : . :* :: *: :* * *:* *** : :: :: LMR3_Hsap IGDYGLAHSNYKEDYYL-TPER-LWIPLRWAAPELLGELHGTFMVVDQSRESNIWSLGVT LMR2_Hsap VGDYGIGFSRYKEDYIE-TDDK-KVFPLRWTAPELVTSFQDRLLTADQTKYSNIWSLGVT LMR1_Hsap IGDYGLAHCKYREDYFV-TADQ-LWVPLRWIAPELVDEVHSNLLVVDQTKSGNVWSLGVT LMR3_Mmus IGDYGLAHSNYKEDYYL-TPER-LWVPLRWAAPELLGELHGSFVLVDQSRESNVWSLGVT LMR2_Mmus VGDYGIGFSRYKEDYIE-TDDK-KVFPLRWTAPELVTSFQDRLLTADQTKYSNIWSLGVT LMR1_Mmus VGDYGLSHCKYREDYLV-TADQ-LWVPLRWIAPELVDEVHGNLLVVDQTKSSNVWSLGVT LMR_Spur IGDYGLALEQYPEDYYI-TKDECHAVPIRWLGPEVMEIRGQDIKPKKITKKSNIWSFGVI AqueK333_Aque VGDYGLSRQLFRGDYYSRTPGQ-TAWPIRWMAPEVFIEVKGMIKSTKETTASNIWSFGIT :****:. : ** * . *:** .**:. : . : .*:**:*: LMR3_Hsap LWELFEFGAQPYRHLSDEEVLAFVVRQQHVKLARPRLKLPYADYWYDILQSCWRPPAQRP LMR2_Hsap LWELFDNAAQPYSNLSNLDVLNQVIRERDTKLPKPQLEQPYSDRWYEVLQFCWLSPEKRP LMR1_Hsap IWELFELGTQPYPQHSDQQVLAYTVREQQLKLPKPQLQLTLSDRWYEVMQFCWLQPEQRP LMR3_Mmus LWELFEFGAQPYRHLSDEEVLAFVVRQQHVKLARPRLKLPYADYWYDILQSCWRPPAQRP LMR2_Mmus LWELFNNAAQPYANLSDLDVLNQVIRERDMKLPKPQLEQPYSDRWYEVLQFCWLPPDKRP LMR1_Mmus IWELFELGAQPYPQHSDGQVLAYAVREQQLKLPKPQLQLALSDRWYEVMQFCWLQPEQRP LMR_Spur MLELSTAADRPYPDLSDEQVLKQVVMDQDIKLDKPNLDLKYAERWFEIMMFCWMDSDTRP AqueK333_Aque LWEVSTFAEQPYPDMTDEEVIEQVARREYCNLRNPVPTFDPLCALFAIMMKCWKRERERP : *: . :** . :: :*: . . :* .* : :: ** ** LMR3_Hsap SASDLQLQLTYLLSERPP-R----------PPPPPPPPRDGPFPWPWPPAHSAPRPGTLS LMR2_Hsap AAEDVHRLLTYLRLQSQR-DSEVDFEQQWNALKP----------------NTNSRDSSNN LMR1_Hsap TAEEVHLLLSYLCAKGAT-EAEEEFERRWRSLRPGGGG-VGPGPGAAGPMLGGVVELAAA LMR3_Mmus SASDLQLQLTYLLSERPP-R----------PPPPPPPPRDGPFPWPWPPSHSAPRPGTLS LMR2_Mmus AAEDVHRLLTYLRMQSQR-DSEVDFEQQWTALKP----------------DTNSRDASSS LMR1_Mmus TAEEVHLLLSYLCAKGTT-ELEEEFERRWRSLRPGGSTGLGSGSAAPAAATAASAELTAA LMR_Spur TVKEVHELLTHLKNNIER-FHMEDFETKWNALKP----------------AMANQSSSEC AqueK333_Aque NMASVLTLLKNVTLNTRGMEAKESIRLKAAA----------------KTKRKSGRPQRES .: *. : : . LMR3_Hsap SPFPLLDG-FP----GADPDDVLTVTESSRGLNLECLWEKA--RRGA--GRGGG------ LMR2_Hsap AAFPILDH-FARDRLGREMEEVLTVTETSQGLSFEYVWEAA--KHDHFDERSRGHLDEGL LMR1_Hsap SSFPLLEQ-FAGDGFHADGDDVLTVTETSRGLNFEYKWEAG--R---------G------ LMR3_Mmus SQFPLLDG-FP----GADPDDVLTVTESSRGLNLECLWEKA--RRGA--GRGGG------ LMR2_Mmus AAFPILDH-FARDRLGREMEEVLTVTETSQGLSFEYVWEAA--KHDHFDEQGRGHPDEAL LMR1_Mmus SSFPLLER-FTSDGFHVDSDDVLTVTETSHGLNFEYKWEAG--C---------G------ LMR_Spur -------------------------SETSQE----------------------------- AqueK333_Aque SQEPLLATSLTMESDGGES---------EEGRSRKSAREEKKGKEEKRDER-RGEENRKL .. LMR3_Hsap --------APAWQPAS--APPAPHANPSNPFYEALSTPSVLPVISARSPSVSSEYYIRLE LMR2_Hsap SYTSIFYPVEVFESSL--SDPGPGKQDDSGQDVPLRVPGVVPVFDAHNLSVGSDYYIQLE LMR1_Hsap --------AEAFPAT---LSPGRTARLQELCAPDGAPPGVVPVLSAHSPSLGSEYFIRLE LMR3_Mmus --------APPWQPAS--APPAPHTNPSNPFYEALSTPSVLPVISARSPSVSSEYYIRLE LMR2_Mmus SYSSMFFPVEVFENSL--SDPGPGKQDDSGQEVPVRAPGVVPVFDAHNLSVGSDYYIQLE LMR1_Mmus --------AEEYPPSGAASSPGSAARLQELCAPDSSPPGVVPVLSAHSPSVGSEYFIRLE LMR_Spur ---------------------------TPQQEI--------------------------- AqueK333_Aque KETKITVEAEVREE-----------------------------------------VVQAE LMR3_Hsap EHGSP------------PEPL--FPNDWDPLDPGVP------------------------ LMR2_Hsap EKSGSNLELD------YPPAL--LTTDMDNPE--RTGPELSQLTALRSVELEESSTDEDF LMR1_Hsap EAAPA-AGHDPDCAGCAPSPP--ATADQDDDSDGSTAASLAMEPLLG----HGPPVDVPW LMR3_Mmus EHGSP------------PEPL--FPNDWDPLDPGVP------------------------ LMR2_Mmus EKSSSNLGL-------DPPAL--LTTEVDKLE--RAGAEEPR-------------TEEDF LMR1_Mmus GAVPA-AGHDPDCAGCAPSPQ--AVTDQDNNSEESTVASLAMEPLLG----HAPPTEGLW LMR_Spur -SLE-IGGGDPLSIGVAKGDPLSVVSDMSQNQTQQVVSVDV------------------- AqueK333_Aque EK---------------------------------------------------------- LMR3_Hsap -----------------------APQA-PQ-A---PSEVPQLVSETWASPLFPAPRPFPA LMR2_Hsap FQSSTDPKDSSLPG---DLHVTSGPES-PFNN---IFNDVD------------------- LMR1_Hsap GRGDHYPRRSLARDPLCPSRSP-SPSAGPLSLAEGGAEDADWGVAAFCPAFFEDP--LGT LMR3_Mmus -----------------------GPQA-PQ-T---PSEVPQLVSETWASPLFPAPRPFPA LMR2_Mmus FQSSAHPKEASSTE---DSRATSIPGS-PF-N---LFSDLD------------------- LMR1_Mmus GPCDHHSHRRQ--GSPCPSRSP-SPGT-PM-L---PAEDIDWGVATFCPPFFDDP--LGA LMR_Spur ------------------------------------------------------------ AqueK333_Aque ------------------------------------------------------------ LMR3_Hsap QSSASGSFLLSGWDPEGRGAGETLAGDPAEVLGERGTAPWVEEEEEEEEGSSPGEDSSSL LMR2_Hsap --------------KSEDLPSHQKIFDLMELNGVQADF-------------KPATLSSSL LMR1_Hsap SPLGSSGAPPLP---------------------------LTGEDELEEVGAR-------- LMR3_Mmus QSSGSGGFLLSGWDPEGRGAGETLAGDPAEVLGEQGTAPWAEEE---EEESSPGEDSSSL LMR2_Mmus --------------KADDLPSHQKIFDLMELNGVQADF-------------KPAILSSSL LMR1_Mmus SPSGSPGAQPSP---------------------------SDEEPEEGKVGL--------- LMR_Spur ------------------------------------TGPSLGQTDHE---DQLFDDLSKK AqueK333_Aque -------------------------------------------------SKKSGKRDSKG LMR3_Hsap G-------------GGPSRRGPLPCPLCSREGA---------------CSCLPLERGDAV LMR2_Hsap DNPKESVITGHFEKEKP-RKIFDSEPLCLSDNLMHQDNFDPLNVQELSENFLFLQEKNLL LMR1_Hsap ---------------RAAQRGHWRSNVSANNNS---------------GSRCP-ESWDPV LMR3_Mmus G-------------GGPSRRGPLPCPLCSREGP---------------CSCLPLERGDAV LMR2_Mmus DDPKDTC---QSDKEKP-HKLLDQGPLCLSESLLHQDHFDPLSVQELSENFLFLQEKNLL LMR1_Mmus ----------------AAQCGHWSSNMSANNNS---------------ASRDP-ESWDPG LMR_Spur G-------------QGQEKNQPFEISFD-------------------------------- AqueK333_Aque G-------------KEKSKKGSKKKETESKK----------------------KVTGDPV : LMR3_Hsap AG---WGGHPALGCPHPPEDDSSLRAER------GSLADLPMAPPAS-------APPEFL LMR2_Hsap KG-----------SLSSKEHINDLQTELKNAGFTEAMLETSCRNSLD-------TELQFA LMR1_Hsap SA----GGH-AEGCPSPK--------------------QTPRASPEPG------YPGEPL LMR3_Mmus AG---WGDHPALGCPHPPEDDSSLRAER------GSLADLPLVPPTS-------APLEFL LMR2_Mmus KG-----------SLTTKEQVSDLQTELKNAGFTSALLESPQRGSES-------SELEFL LMR1_Mmus YVSSFTDSY-RDDCSSLE--------------------QTPRASPEVGHLLSQEDPRDFL LMR_Spur -------------------------------------------EPEQE------AP---- AqueK333_Aque ----------PTSVPVVPHKDE-----H------SDI--------------------SDM LMR3_Hsap DPLMGAAAPQYPGRGPPPAPPPPPPPPRAPADPAASPDPPSAVASPGSGLSSPGPKPGDS LMR2_Hsap ENKPGLSLLQEN--------------------------------------------VSTK LMR1_Hsap LGLQA-ASAQEPGCCPG-LPHLCSAQGLAPA---PCLVTPSWTETASSGGDHPQAEPK-L LMR3_Mmus DPLMGAAAPQYPGRGPPPAPPPPPPPPRASAEPAASPDPPSALASPGSGLSSPGPKPGDS LMR2_Mmus ENTLDFPLSQGD----------------------------------------------TR LMR1_Mmus PGLVAVSPGQEPSRPFN-LLPLCPAKGLAPA---ACLITSPWTEGAVGGAENPIVEPK-L LMR_Spur ---------------------TNMPETETVSEIIPSVATPQANMAPPAGGDSTHELSFED AqueK333_Aque DD------IFYP-SGPPPAP-------------------AAAHASPPSD----------- LMR3_Hsap GYETETPFSPEGAFPGGGA--AEEEGVPRPRAPPE--PPDPGAP-RPPPDPGPLPLPGPR LMR2_Hsap GDDTDVML------TGDTLSTSL-QSSPEVQVPPTSFETEETPR-RVPPD--SLPTQGET LMR1_Hsap ATEAEGTTGPRLPLPSVPS--PSQEGAPLPSEEAS--APD--AP-DALPDS-PTPATG-- LMR3_Mmus GYETETPFSPEGAFPGGGA--AEEEGVPRPRAPPE--PPDPGAP-RPPPDPGPLPLPGSQ LMR2_Mmus GQN-----------EGAGV--RR-HSGTSPQASPAL-LTEEGSP-TAPTD--PILKPEET LMR1_Mmus AQEAEGSAEPQLPLPSVPS--PSCEGASLPSEEAS--APD------ILPAS-PTPAAG-- LMR_Spur AFDTPTPQGDRKTD-TLSF--GLDDSVPSAEVTPN--TPDFFSSEDVNPVEASTPFPSSQ AqueK333_Aque ---------------------DEESWDERVIPPPH--PPSQLPS-QP-----------QS . .. LMR3_Hsap EKPTFVVQVSTEQLLMS------------------------------------------- LMR2_Hsap QPTCLDVIVPEDCLHQDISPDAVTVPVEILSTDARTHSLDNRSQDSPGESEETLRLTESD LMR1_Hsap ------GEVSAIKLASA-------------------LNGSSSS----------------- LMR3_Mmus EKPTFVVQVSTEQLLMS------------------------------------------- LMR2_Mmus -KSFRDVRVPEDSICLELGPDPVTVGVEIPATDAKTLDGGNRPPDVTCQSKEALSLTNRH LMR1_Mmus ------SWVTVPEPAPT-------------------LESSGSS----------------- LMR_Spur Q-PNMQVSIDTS---------VSAG----------------------------------- AqueK333_Aque ------------------------------------------------------------ LMR3_Hsap -------------------------------LREDV------------------------ LMR2_Hsap SVLADDILASRVSVGSSLPELGQELHNKPFSEDHHSHRRLEKNLEAVETLNQLNSKDAAK LMR1_Hsap ------------------PE-----VEAPSSEDEDT------------------------ LMR3_Mmus -------------------------------LREDV------------------------ LMR2_Mmus PILVNDITAQ-GSVESCLPESRQDLQNEPFSEDPLSVSSLEKHSEAAETLNQLNSKAAPE LMR1_Mmus ------------------LG-----QEAPSSEDEDT------------------------ LMR_Spur ------------------------------------------------------------ AqueK333_Aque ------------------------------------------------------------ LMR3_Hsap -TRNLLG---EKGATARETGPRKAGRGPGNREKVPGLNRDPTVLGNGKQAPSLSLP---- LMR2_Hsap EAGLVSALSSDSTS--QDSLLEDSLSAP-FP-------ASEPSLETPDSLESVDVHEALL LMR1_Hsap -AEATSGIFTDTSS--DGLQARRPDVVPAFR-------SLQKQVGTPDSLDSLDIPSSAS LMR3_Mmus -TKNLLG---DKGSTPGETGPRKAGRSPANREKGPGPNRDLTSLVSRKKVPSRSLP---- LMR2_Mmus DAALASALSSDSTS--QDSLLEDSLSTP-IP-------TSEQSVETPDSLDSVDVREALL LMR1_Mmus -TEATSGVFTDLSS--DGPHTEKSGIVPALR-------SLQKQVGTPDSLDSLDIPSSAS LMR_Spur -----------------GYGTAGSNLLEGNDSTVTFTESFNTMSS--------------- AqueK333_Aque ------------------------------------------------------------ LMR3_Hsap VNGVTVLENGDQRAPGIEEKAAENGALGSPEREEKVLENGELTPPRREEKALEN---GEL LMR2_Hsap DS-LGSHTPQKLVPPD---KPADSGY-ETEN---------------LESPEWTLHPAPEG LMR1_Hsap DGGYEVFSPSATGPSGGQPRALDSGY-DTEN---------------YESPEFVLKEAQEG LMR3_Mmus VNGVTVLENGKPGVPDMKEKVAENGL-ESPE---------------KEERALVN---GEP LMR2_Mmus ES-LGSHTPRKLLPPD---KPADSGY-ETEN---------------LESPEWTLHPAPEG LMR1_Mmus DGGCEVLSPSAAGPPGGQPRAVDSGY-DTEN---------------YESPEFVLKEAHES LMR_Spur ----NPFSSSTSSEPGGFVSAVESAG-DRSL------EDSR----DHENNGFG---EFES AqueK333_Aque -------------------QRESYRY-SRES---------------WDSFDDDYD----- . :. LMR3_Hsap RSPEAGEKVLVNGGLTPPKSEDKVSENGGLRFPRNTERPPETGPWRAPGPWEKTPESWGP LMR2_Hsap TADS-------------------------------------------------------E LMR1_Hsap CEPQ-------------------------------------------------------- LMR3_Mmus MSPEAGEKVLANGVLMSPKSEEKVAENGVLRLPRNTERPPEIGPRRVPGPWEKTPET--- LMR2_Mmus TADS-------------------------------------------------------D LMR1_Mmus SEPE-------------------------------------------------------- LMR_Spur SMG--------------------------------------------------------- AqueK333_Aque -------------------------EDEQ------------------------------- LMR3_Hsap APTIGEPAPETSLERAPAPSAVVSSRNGG--------------ETAPGP----------- LMR2_Hsap PATTGDGGH---SG--LPPNPVIVISDAGDGHRGTEVTPETFTAGSQGSYRDSAYFSDND LMR1_Hsap --AFAELAS---EGEGPGPETRLSTSLSG--------------LNEKNPYRDSAYFSDLE LMR3_Mmus ----GGLAPETLLDRAPAPCEAALPQNGL--------------EMAPGQ----------- LMR2_Mmus AAAAGDSGH---SS--LPPNPVIVISDAGDGHRGAEGPPQSFTLGPQSSYRDSAYFSDND LMR1_Mmus --AFGEPAS---EGESPGPDPLLSVSLGG--------------LSKKSPYRDSAYFSDLD LMR_Spur -LSFGTP----------------------------------------------------- AqueK333_Aque ----------------------------TDGVRSAPLPPTQFS--------------QEE LMR3_Hsap ------LGPAPKNGTLEP---------GTERRAPETGGAPRAPGAGRLDLGSGGRAPVGT LMR2_Hsap SEPEKR--SEEVPGTSPSALVLVQEQPLPEPVL-------PEQSPAAQD--SC-L----- LMR1_Hsap AEAEATSGPEKKCGGDRA--------PGPELGL-------PSTGQPSEQ--VC-LRPGVS LMR3_Mmus ------LGPAPKSGNPDP---------GTEWRVHESGGAPRAPGAGKLDLGSGGRALGGV LMR2_Mmus SEPDKK--PEEVPGTSANALVLVKGQSPPESVV-------PEESSDVRE--GC-L----- LMR1_Mmus AESEPTFGPEKHSGIQDS---------QKEQDLR----SPPSPGHQSVQ--AF-PRSAVS LMR_Spur -----------------------------------------SEGD--------------- AqueK333_Aque EEEEE-------------------EPPLPPQDL-------PPDLTPNEQ--ID-W----- LMR3_Hsap GTAPGGGPGSGVDAKAGWVDNTRPQPPPPPLPPPPEAQ--------------PRRLEPAP LMR2_Hsap -EARKSQPDESCLSALHN-SSDLE-------------L--------------RATPEPAQ LMR1_Hsap GEAQGSGPGEVLPP-LLQLEGSSPEPST---------C--------------PSGLVPEP LMR3_Mmus GTAPAGGPASAVDAKAGWVDNSRPLPPPPQ---PLGAQ--------------QRRPEPVP LMR2_Mmus -EAPQDKPDQSRVSTLQN-SCHSE-------------L--------------QETLQPTP LMR1_Mmus --------SEVLSP-PQQ--SEEP-------------L--------------PEVPRPEP LMR_Spur ------------L----------------------SSV--------------RETP--TP AqueK333_Aque -------------------EESEPVATPPGVYP-TDEVINRTNPYATELQDEEEVSLPPP LMR3_Hsap PRARP--EVAPE-GEPGAPDSRAGGDTALSGDGDPPKPERKGPEMPRLFLDLGPPQGNSE LMR2_Hsap TGV--PQQVHPTEDEASSPWSVLNAE--------LSSGDDFETQDDR-PCTLASTGTNTN LMR1_Hsap PEPQGPAKVRPGPSPSCSQFFL--------LTPVPLRS-----------------EGNSS LMR3_Mmus LKARP--EVAQE-EEPGVPDNRLGGDMAPSVDEDPLKPERKGPEMPRLFLDLGPPQGNSE LMR2_Mmus ADA--SRESCPVNDEASSPLSLLNSE--------PSSCDDLDTQEDR-PCTLASTGTNTN LMR1_Mmus LGAQGPVGVQPVPGPSHSKCFP--------LTSVPLIS-----------------EGSGT LMR_Spur GGQ--------------------------------------NSTSSDLFGDL-------- AqueK333_Aque LPAEE--DDIGTDEESLQPI-------------EPVKLDRF------------------- LMR3_Hsap QIKARL-SRLSLALP-PLTLTPFPGPGPRRPPWEGADAGAAGGEAGGAGAPGPAEEDGED LMR2_Hsap ELLAYTNSALDKSLS-----SHSEGPKLKEPDIEGKYLGKLGVSGMLDLSEDGMDADEED LMR1_Hsap EFQGPP-GLLSG----PAPQKRMGGPGTPRAPLRLALP---GLPAALEGRPE--EEEEDS LMR3_Mmus QIKAKL-SRLSLALP-PLTLTPFPGPGPRRPPWEGADAGAAGGEAGGAGAPGPAEEDGED LMR2_Mmus ELLAYMSSTLDKSLP-----SHLESSKLKEPDIEGKYLGKLCVSGMLDLSEDGMDADEED LMR1_Mmus EPQGPS-GQLSG----RAQQGQMGNPSTPRSPLCLALP---GHPGALEGRP---EEDEDT LMR_Spur ---SQPSNPFDSSAASVSFGVGVESPAVKE-----------------------VSFDQLA AqueK333_Aque -------------------------------------------------------ARVDS LMR3_Hsap EDEDEEEDEEAAAPGAAAGPRGPGRA-RAAPVPVVVSSADADAARP---LRGLLKSPRG- LMR2_Hsap ENSDD-SDEDLRAFNLHSLSSESEDE-TEHPVPIILSNE---DGRH---LRSLLKPTAAN LMR1_Hsap EDSDE-SDEELRCYSVQEPSED-SEE-EAPAVPVVVA--ESQSARN---LRSLLKMPSL- LMR3_Mmus EDEDEE-DEEAA------GSRDPGRT-REAPVPVVVSSADGDTVRP---LRGLLKSPRA- LMR2_Mmus ENSDD-SDEDLRAFNLHSLSSESEDD-TEHPVPIIVSND---DGRH---LRSLLKPSAAE LMR1_Mmus EDSEE-SDEELRCYSVQEPSED-SEE-EPPAVPVVVA--ESQSARN---LRSLLKMPSL- LMR_Spur QNGE-D-KKDLHSFSAITLKEH-EKE-STD-VPPVGD--HEITPQGYAEVSAAAKK-S-Y AqueK333_Aque RGFDD-SDEINTPMTETGGGRGAEEDSDDINVPVQS--EEKSTGKK---TKASKKEEKE- .. : .: ** : . * LMR3_Hsap ADEPEDSELERKRKMVSFHGD--------VTVYLFDQETPTNELSVQAPPEGDTDPST-- LMR2_Hsap APDPLPEDWKKEKKAVTFFDD--------VTVYLFDQETPTKELGPCGGEACGPDLSG-- LMR1_Hsap LSETFCEDLERKKKAVSFFDD--------VTVYLFDQESPTRELGEPFPGAKESPPTFLR LMR3_Mmus ADEPEDSELERKRKMVSFHGD--------VTVYLFDQETPTNELSVQGTPEGDTEPST-- LMR2_Mmus AIEQLPEDWKKEKKAVTFFDD--------VTVYLFDQETPTKELGHCGGEAHGPGPSS-- LMR1_Mmus LSEAFCDDLERKKKAVSFFDD--------VTVYLFDQESPTRETGEPFPSTKESLPTFLE LMR_Spur GMTMLTVTSGKKKKSIKILKEEDGEDAGDAASHVTMVTNGSSEMA---KDDG--IST--- AqueK333_Aque REKAKKKELKEKKKKEK-------------------QQRSIKKKKSKGGE---------- .::* . : LMR3_Hsap -PPAPPTPP-HPATPGDGFP-SNDSGFGGSFEWAEDFPLLP------------------- LMR2_Hsap -PAPASGSP-YLSRCINS--ESSTDEEGGGFEWDDDFSPDPFMSKTTSNLLSSKPSLQTS LMR1_Hsap GSPGSPSAPNRPQQA-DGSPNGSTAEEGGGFAWDDDFPLMTAKAAFAMALDPAAPAPA-- LMR3_Mmus -PPAPPTPP-HPTTPGDGFP-NSDSGFGGSFEWAEDFPLLP------------------- LMR2_Mmus -PAASSSSP-YLGRCMNS--ESSTDEEGGGFEWDDDFSPDPFMSKTT-SLLGSKPSLQTS LMR1_Mmus GGPSSPSATGLPLRA-GHSPDSSAPEPGSRFEWDGDFPLVPGKAALVTELDPADPVLA-- LMR_Spur APPASGPGPN-LL-DL-DI-PVSGLDQGSGL----------------------------- AqueK333_Aque ------------------------------------------------------------ LMR3_Hsap ----PPGP----------PLCFSRFSVSPALETP----------GPPARAPDARPAG--- LMR2_Hsap KYFSPPPPARSTEQSWPHSAPYSRFSISPANIASFSLTHLTDSDIEQGG-----SSE--- LMR1_Hsap ---APTPT----------PAPFSRFTVSPAPTSRFSITHVSDSDAESKRGPEAGAGG--- LMR3_Mmus ----PPGP----------PLCFSRFSVSPALETP----------GPPARAPDARPAG--- LMR2_Mmus KYFSPPPPARSAEQSWPHVSPCSRFSISPANIASFSLTHLTDSDIEQGG-----SSE--- LMR1_Mmus ---APPTP----------AAPFSRFTVSPTPASRFSITHISDSDAQSVGGPAAGAGG--- LMR_Spur ----APGL----------TLGFGTIEVEVSNDGGDAV-------VVQSQSPDSVEFGSFE AqueK333_Aque ------------------------------------------DD---------KEKGGDE LMR3_Hsap --PVEN LMR2_Hsap D-GEKD LMR1_Hsap E-SKEA LMR3_Mmus --PVEN LMR2_Mmus D-GDKD LMR1_Mmus R-YTEA LMR_Spur DVSKEL AqueK333_Aque P-ALVW