CLUSTAL W (1.83) multiple sequence alignment SgK223_Hsap MHQTLCLNPESLKMSACSDFVEHI-------------WKPGSCKNCFCL-RSDHQLVAGP SgK269_Hsap -------------MSACNTFTEHV-------------WKPGECKNCFKP-KSLHQLPPDP SgK223_Mmus -------------MSACSDFVEHI-------------WKPGSCKNCFCL-RSDHQPTAGH SgK269_Mmus -------------MSACNTFTEHV-------------WKPGECKNCFKP-KSLHQLPPDS Spk390_Spur -------------MEC-------------------------HCAACSSP----------- AqueK185_Aque -------------MNKSSTRTLQAIGHDEGDSSPEEFAIPRAATICTSALRGRRQL-SEP *. . * SgK223_Hsap PQPRAGSLPPPPRLPPRPENCRLEDEGVNSSP-YSKPTIAVKPTMMSSEASDVWTEANLS SgK269_Hsap EKAPITH-GNVKTNANHSNNHRIRNTGNFRPPVAKKPTIAVKPTMIVADGQSICGELSIQ SgK223_Mmus PKARANSLPAGTRLPARPENCRLDDEGVNGLA-YSKPTIAVKPTMMTSETSDLWTEASLS SgK269_Mmus EKTPITH-GSGKTNANHSNNHRVRSTGNFRPPVAKKPTIAVKPTMMVADGQSVCGELSIQ Spk390_Spur ------H-GSRKRMMNI------------------------------------------- AqueK185_Aque PSDML------------------------------------------------------- SgK223_Hsap AEVS--Q--VIWRRAPGKL---PLPK--QED-APVVYLGSFRGVQKPAGP---------- SgK269_Hsap EHCENKPVIIGWNRNRAALSQKPLNNNNEDD-EGISHVPKPYGNNDSAKKMSDNNNGLTE SgK223_Mmus AEVP--K--VNWRRTPGKL---LLPK--QED-EPIVYLGSFRGLQKPASP---------- SgK269_Mmus EHCENKPVILGWNQNKTSLSQKPLNNNSEGDAEGFGSDPQQCANNDSAQKISNNNNGLTE Spk390_Spur ---------HGANRANI-APQKPARRRQ-------------------------------- AqueK185_Aque ------------------------------------------------------------ SgK223_Hsap --------STSPD--GN---------------------SRCPPAYTMVGLHNLEPRGERN SgK269_Hsap VLKEIAGLDTAPQIRGNETNSRETFLGRINDCYKRSLERKLPPSCMIGGIKETQG--K-- SgK223_Mmus --------LACTD--GN---------------------SRCPPAYTMVGLHNLEARVDRN SgK269_Mmus VLKEIAGLEATPPVRGNETNARETFLGRINDCYKRSLERKIPPSCMTGSMKDSQG--K-- Spk390_Spur ---------------RNRTTGFEDLPSRVKRMAPKTPEK--PTPCDTG------------ AqueK185_Aque ------------------------------------------------------------ SgK223_Hsap IAFHPVSFPEEKAVHKEKPSFPYQDRPS---------------TQESFRQKLAAFAGTTS SgK269_Hsap ---HVILSGSTEVISNEGGRFCYPEFSSGEESEEDVLFSNMEEEHESWDESDEELLAMEI SgK223_Mmus TAFQPVSFQEEKAG--------REELPS---------------AHESFRQKLAAFAGMTS SgK269_Mmus ---HVILSGSAEVISNEGGRFCYPEFSSGEESEEDVLFSNMEEEHESWDESDEELLAMEI Spk390_Spur ------------------------------------------------------------ AqueK185_Aque ------------------------------------------------------------ SgK223_Hsap GCHQGP----------GPL-------RESLPSEDDSDQR-CSPSGDSEGGEYCSILDCCP SgK269_Hsap RMRGQPRFANFRANTLSPVRFFVDKKWNTIPLRNKSLQRICAVDYDD---SYDEILNGYE SgK223_Mmus SCPKGPRPC----TSPQPL-------RESLPSEDDSDQR-CSPSGDSEGGEYCSILDCCP SgK269_Mmus RMRGQPRFANFRANTLSPVRFFVSKKWNTIPLRNKSLQRICAVDYDD---SYDEILNGYE Spk390_Spur ---------------------------------------------D-------DVFD--- AqueK185_Aque ------------------------------------------------------------ SgK223_Hsap GSPVAKAASQTAGSRGRHGGRDCSPTCWEQGKCSGPAEQEK--RGPSFPKECCSQG-PTA SgK269_Hsap EN-SVVSY--GQGS---IQS-MVSSDST--SPDSSLTEESRSETASSLSQKICNGGLSPG SgK223_Mmus ESKDAVHS--TEGS-GRRGG-DCSPTCREQGPRTRPTEEEK--QGLSFPRECCGQG-STA SgK269_Mmus EN-SGVSY--GQGS---VQS-TISSDCT--SPGSSFTEESRSETASSLSQKVCNGGISPG Spk390_Spur ----------GNGA---------------------------------------------- AqueK185_Aque ----------------------------------------------------RDISLSPL SgK223_Hsap HPSCLGPK-KLSLTSEAAISSDGLSCGSGSGSGASSPFVPHLESDYCSLMKE-------- SgK269_Hsap NPGDSKDMKEIEPNYESP-SSNNQDKDS-SQASKSSIKVPETHKAVLALRLEEKDGKIAV SgK223_Mmus NPPRLGPK-KPSLNSEAASSSDGLSCGS-SRSGASSPFAPHLENDYCSLVKE-------- SgK269_Mmus NPGNSKDIAETESNFESP-PGNNEEKDE-SLTSKSSVKVPETHKAVLALRLQEKDGKIAV Spk390_Spur ------------------------------------------------------------ AqueK185_Aque P------------------PARSQTVDS-KQV---------------------------- SgK223_Hsap ----PAPEKQQDPGCPGVTPSRCLGLTGEPQPPAH--PRE-------------------- SgK269_Hsap QTEKEESKASTDVAGQAVTINL-VPTEEQAKPYRVVNLEQPLCKPYTVVDVSAAM----A SgK223_Mmus ----PASGKQQDLSGHFLTSGKCVGQAAELQPASL--LRD-------------------- SgK269_Mmus HTEKPESKASTDIAGQAVTISL-VPVEEQTKPYRVVNLEQPLCKPYTVVDVSAAM----A Spk390_Spur ------------------------------------------------------------ AqueK185_Aque ----------------------------------------GVVKPYAVVDLHETLKQIQS SgK223_Hsap ------------------------------------------------------------ SgK269_Hsap SEHLEGPVNSPKTKSSSSTPNSPVTSSSLTPGQISAHFQKSSAIRYQEVWTSSTSPRQKI SgK223_Mmus ------------------------------------------------------------ SgK269_Mmus SEHLG----RPKIKGSSSTPNSPVTSPALTPGQINAHLKKSSAIRYQEVWTSSTSPRQKI Spk390_Spur -----------------------------------------KQLVFDDIHLSS------- AqueK185_Aque QDHFL----RPRVGSCG------------------------------------------- SgK223_Hsap ----------------------AT------------------------------------ SgK269_Hsap PKVELITSGTGPNVPPRKNCHKSAPTSPTATNISSKTIPVKSPNLSEIKFNSYNNAGMPP SgK223_Mmus ----------------------PV------------------------------------ SgK269_Mmus PKIELSTGGPGPNVPPRKNCHKSAPTSPTATNISSKTIPVKSPNLSEIKFNSYNNAGMPP Spk390_Spur -------------SPPLKSALRSTQSEPLRTDAEGKVVPKRPVR---------------- AqueK185_Aque ------------------------------------------------------------ SgK223_Hsap -----QPEPIYAESTKRKKAAPVPSKSQAKIEHAAAAQGQGQVCTGNAWAQKAASGWGRD SgK269_Hsap FPIIIHDEPTYARSSKNAIKVPIVINPNAYDNLAIYKSFLGT------------------ SgK223_Mmus -----QPEPIYAESAKRKKAAPGPPRPEPKKEQVPAGHSQGQVWTGDTWIQKTPPSWSQD SgK269_Mmus FPIIIHDEPSYARSSKNAIKVPIVINPNAYDNLAIYKSFLGT------------------ Spk390_Spur ------------------------------------------------------------ AqueK185_Aque -------TVFLYDATKRRIEAPLALQR--------------------------------- SgK223_Hsap --SPDPTPQVSATITVMAAHPEEDHRT--------------------------------- SgK269_Hsap ----SGELSVKEKTTSVISHTYEEIETESKVPDNTTSKTTDCLQTKGFSNSTEHKRGSVA SgK223_Mmus REGANPAPQVATTITVIAAHPEEDHRT--------------------------------- SgK269_Mmus ----SGELSVKEKTTSVISHTYEEIETESKVSDSTPSKLTDCPQAKGFSNSTERKRGSVA Spk390_Spur ------------------------------------------------------------ AqueK185_Aque ------------------------------------------------------------ SgK223_Hsap -------------------IYLSSPDSAVGVQWPRGPVSQNSEVGEEETSAG-QGLSSRE SgK269_Hsap QKVQEFNNCLNRGQSSPQRSYSSSHSSPAKIQRATQEPVAKIEGTQESQMVG--SSSTRE SgK223_Mmus -------------------IYLSSPDSAVGVQWPRGPSNQDLQAGEEEPLVA-QGLTSRE SgK269_Mmus QKVQEFNNCLNRGQSSPQRSYSSTHSSPAKIQRPTQEPAGKTEGAQGSQVPGSSSNSTRE Spk390_Spur ---------------------IIAPED-----------------------------AAID AqueK185_Aque ------------------------------------------------------------ SgK223_Hsap SHAHSASES---------------------KPKERPAIPPK--LSKSSPVGSPVSPSAGG SgK269_Hsap KASTVLSQIVASIQPPQSPPETPQSGPKACSVEELYAIPPDADVAKSTPKSTPVRPK--- SgK223_Mmus SHPHNVTEN---------------------TAKEKPAIPPK--LSKSSPGGSPVSPA--- SgK269_Mmus KASAVLCQIVASIQPPQTPPEAPQSSPKACSVEELYAVPPDADTTKSIPKNPPVRPK--- Spk390_Spur THSHSTVLR---------------------SDYTNLALVPQV--HLDD------------ AqueK185_Aque --------R---------------------ERKERKSIVPK--RKAP---------P--- :: *. SgK223_Hsap PPVSPLADLSDGSSGGSSIGP-------QPPSQGPADPAPSCRTNGVAI-SDPSRCPQPA SgK269_Hsap ---SLFTSQPSGEAEAPQTTDSPTTKVQKDPSIKPVTPSPSKLVTSPQS-EPPAPFPPPR SgK223_Mmus ---PPLTDHSDGNTGGSSVGP-------QLLSRVPANLTSSCHTNGVATAGDSAKCPPPA SgK269_Mmus ---SLFTSQSSGEGEAHQTTESPTAKIQKDPSTKPVTSPPSKLVTSAQS-EPPPPFPPPR Spk390_Spur -------------------------TIH-------------------------------- AqueK185_Aque ---PPVTRSPGHAYGGRAKK--------------------NTLTTGNRM-SRSSSVPTPL SgK223_Hsap ASSAS---------------------------------------EQRRPRF-QAGTWSRQ SgK269_Hsap STSSPYHAGNLLQRHFTNWTKPTSPTRSTEAESVLHSEGSRRAADAKPKRWISFKSFFRR SgK223_Mmus TSSSVL--------------------------------------DQRRPRY-QTGAWSRQ SgK269_Mmus STSSPYHASNLLQRHFTNWTKPTSPTRSTEAESILHSEGSRRAADAKPKRWISFKSFFRR Spk390_Spur ------------------------------------------------------------ AqueK185_Aque ITDA-------------------------------------------------------- SgK223_Hsap CRIEEEEEVEQEL---------------------LSHSWGRETKNGPTDHSNSTTWHRLH SgK269_Hsap RKTDEEDDKEKEREKGKLVGLDGTVIHMLPPPPVQRHHWFTEAKGESSEKPAIVFMYRCD SgK223_Mmus CRIEEEEEVGQEL----------------------SQSWGRELENGTADHSNSSTWHRLH SgK269_Mmus RKTDEEEEKEKEREKGKLVGLDGTVIHMLPPPPVQRHHWFTEAKGEASEKPAIVFMYRCD Spk390_Spur ------------------------------------------------------------ AqueK185_Aque -----EEEV-----------------------------------------HNSSV----- SgK223_Hsap PTDGS-SGQNSKVG------TGMSKSASFAFEFPKDRSGIETFSPPPPPPKSRHLLKMNK SgK269_Hsap PAQGQLSVDQSKARTDQAAVMEKGRAENALLQ---DSEKKRSHSSPSQIPKK-------- SgK223_Mmus PIDGT-SGQNSKTN------SGMSKSASFAFEFPKDRGRLEAFSPPPPPPKSRHLLKMNK SgK269_Mmus PDQGHLSVDQSKAG------AEKGRAEEVLLR---NSEEKKSSYLPSQIPDK-------- Spk390_Spur ------------------------------------------------------------ AqueK185_Aque ------------------------------FIPLNDVSKSKEKSPPCKPPRTQS------ SgK223_Hsap SSSDLEKVSQGSAE--------------------SLSPSFRGVHVSFTTGSTDSL-ASDS SgK269_Hsap ---ILSHMTHEVTEDFSPRDPRTVVGKQDGRGCTSVTTALSLPELEREDGKEDISDPMDP SgK223_Mmus SSSDLEKVSQSSAE--------------------SLSPSFRGAHVSFTTGSTDSL-ASDS SgK269_Mmus ---ACSRVTHEVAGELSPRDPRTPAGKQDG---TSVTPTLPPPDLEREEEKDDTLDPTDV Spk390_Spur --KDAETQVNDSPQRV-------------------------------------------- AqueK185_Aque -----------------------------------------------TYMS--------- SgK223_Hsap RTCSDGGPSSELAHSPTNSGKKLFAPVP-----FPSGS----------TEDVSPSG-PQQ SgK269_Hsap NPCSATY---------SNLGQSRAAMIPPKQPRQPKGAVDDAIAFGGKTDQEAPNASQPT SgK223_Mmus RPCSDGGPSYEPTHSPTISGKKLFAPVP-----FPSGS----------TEDVSPGGGPAQ SgK269_Mmus SPCSATY---------SNLGQSRAAMIPPKHPRHPKGAVDDAIAFGEKTDQEGLNASQPT Spk390_Spur ------------------------------------------------------------ AqueK185_Aque ---------------------------------------FDEVAIGAKTA---------- SgK223_Hsap PPPLPQKKIVSRAASSPDGFFWTQGSPKPGTASPKLNLSHSETNV--HDESHFSYSLSPG SgK269_Hsap PPPLPKKMII-RANTEPISKDLQK---------------SMESSLCVMANPTYDIDPNWD SgK223_Mmus PPPLPQKKIVSRAASSPDGFFWTQGSPKPRTASPKLNLSHSETNVCAHDEPPFNCSLNSG SgK269_Mmus PPPLPKKMI--RANTEPISKDLQK---------------AMESSLCVMANPTYDIDPNWD Spk390_Spur ------------------------------------------------------------ AqueK185_Aque ------------------------------------------------------------ SgK223_Hsap NRHHP----------VFSSSDPLEKAFKGSGHWLPAAGLAGNRGGCGSPGLQCKGAPS-- SgK269_Hsap ASSAGSSISYELKGLDIESYDSLERPLRKERP---VPSAANSISSLTTLSIKDRFSNSME SgK223_Mmus NRSHH----------VFSSSEPLGKAFKGNAPWAPALGLANSKGGCGSPSLQCRAATS-- SgK269_Mmus ASSAGSSISYELKGLDVESYESLERPLHKERP---VPSAANSISSLATLSVKDRFSNSME Spk390_Spur -----------------------------------EPSLADARCS--------------- AqueK185_Aque ----------------CSDYEPLHRFSQQNSP---SGTMRSS-------------ITA-- . SgK223_Hsap ASSSQLSVSSQASTGSTQLQLHGLLSNISSKEGTYAKLGGLYTQSLARLV---------- SgK269_Hsap SLSSRRGPSCRQGRGIQKPQRQALYRGLENREEVVGKIRSLHTDALKKLA---------- SgK223_Mmus TSSSQLSVSSQASSSSTQLQLHSLLSSISSKEGTYAKLGGLYTQSLARLV---------- SgK269_Mmus SLSSRRGLSYRQTRSIQKPQRQALYRGLDNREEVVGKLRSLHTDALKRLA---------- Spk390_Spur -------LNPLNSSSLDQSSQRNL----------LNDVSAVHRQALTQLSRTTPRTPLDW AqueK185_Aque TISSDVAIASLSLLHQFQELFDDT----------LGNIASRHFEELTSTD---------- : .: . : : * SgK223_Hsap AKCEDLFMGGQKKELHFNENNWSLFKLTCNKPCCDSGDAIYY-CATCSEDPGSTYAVKIC SgK269_Hsap VKCEDLFMAGQKDQLRFGVDSWSDFRLTSDKPCCEAGDAVYY-TASYAKDPLNNYAVKIC SgK223_Mmus TKCEDLFMGGQKKELRFNENYWSLFKLTCNKPCCDSGDAIYY-CATCSEDPGSIYAVKIC SgK269_Mmus VKCEDLFMAGQKDQLRFGVDSWSDFRLTSDKPCCEAGDAVYY-TASYAKDPLSNYAVKIC Spk390_Spur TECEDSVWKEQ----------------ATSEPKCRSAGAAFF-GVTHPTNPSSPTGLLVC AqueK185_Aque Q--------------HLQDMNWSDITDSVDL---KNKHQLYFHMQPISLEPLD------- : . :: . . :* . SgK223_Hsap KAPEPKTVSYC-----SPSVPVHFNIQQDCGHFVASVPSSMLS--SPDAP-K-------- SgK269_Hsap KSKAKESQQYYHSLAVRQSLAVHFNIQQDCGHFLAEVPNRLLPWEDPDDPEKDEDDMEET SgK223_Mmus KTPEPKSASYC-----SPSVPVHFNIQQDCGHFVASVPSSMLA--SPDTSSK-------- SgK269_Mmus KSKAKESQQYYHSLAVRQSLPVHFNIQQDCGHFLAEVPSRLLPWEDPDAPEKAEDGTEDS Spk390_Spur CDPNKATQVL-QMAEMTKSMATHPNLISV-SH----------------A-TK-------- AqueK185_Aque ------RDRHRTELSIAKTLTPHLNLSLPRGTL-QQAPVDY------------------- ::. * *: . SgK223_Hsap -----------DPVPALPTHPPAQ-------------EQDCVVVITREVPHQTASDFVRD SgK269_Hsap EEDAKGETDGKNPKPCSEAASSQKENQ----GVMSKKQRSHVVVITREVPCLTVADFVRD SgK223_Mmus -----------DTAPAVSPQPPAQ-------------EQDCVVVITREVPHQTASDFVRD SgK269_Mmus EEEGKAETLGGNPEPCSETEPSQKENQ----RVTNRKQRSHVVVITREVPHLTVADFVRD Spk390_Spur -----------DTIT---IDPSLLEQRKTRSSPLTGGSIETALVFTDDLPTGNVAEYVSQ AqueK185_Aque ----------------IEFLPDAKE---------------YVVRDTSCLPDKVPLEKILP . .: * :* : : SgK223_Hsap SAASHQAEPEAYERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLVHCT-LQAG-PGP SgK269_Hsap SLAQHGKSPDLYERQVCLLLLQLCSGLEHLKPYHVTHCDLRLENLLLVHYQ-PGGTAQGF SgK223_Mmus SMASHRAEPEVYERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLAHCN-PQSS-PGP SgK269_Mmus SLAHHGNSPDLYERQVCLLLLQLCSGLEHLKPYHVTHCDLRLENLLLVQHQ-PGGAAQGP Spk390_Spur NTEKHEHLPEVYERDVALMLLQLCQGLCELQSRSMCLESLKLDHLLLTESGLPGGG---- AqueK185_Aque -LWNKSLSEEEYMQAVLLILVQVLRGLNYLYNNGIVHRDIGIESLLAWTYR-SSADH--- : : * : * ::*:*: ** * : .: :: ** . SgK223_Hsap APAPA-PAPAAAAPPCSSAAPPAGGTLSPAAGPASPEGPREKQLPRLIISNFLKAKQKPG SgK269_Hsap G--PAEPSPTSSYP------------------------------TRLIVSNFSQAKQKSH SgK223_Mmus SATPTVPTTTSRCP---SAA--------PAATTACQGGPGEKQLPRLIISNFLKAKQKPG SgK269_Mmus S--PADPCPTLACP------------------------------TRLIVSNFSQAKQKSH Spk390_Spur --------------------------------------------HRLVINHLMGAEV--- AqueK185_Aque ---------------C-----------------------------IIKLKNFTYALHRPG : :.:: * SgK223_Hsap GTPNLQ----------QKKSQARL------APEIVSASQYRKFDEFQTGILIYELLHQPN SgK269_Hsap L-VDPE----------ILRDQSRL------APEIITATQYKKCDEFQTGILIYEMLHLPN SgK223_Mmus GTTNLQ----------QKKSQARL------APEIVSASQYRKFDEFQTGILIYELLHQPN SgK269_Mmus L-VDPQ----------ILRDQSRL------APEIITATQYKKCDEFQTGILIYEMLHLPN Spk390_Spur ------------------VSPART------DQKEVASKLEQKCHEFDVGILIFEFLHQPN AqueK185_Aque PISATTFVFAYDELSWLGGVESHLPPEIVDTPSNVNTLDYSHTDSFAVGCLIHELMTGTS :: . : : : ..* .* **.*:: .. SgK223_Hsap PFEVRAQLRERDYRQEDLPPLPALSLYSPGLQQLAHLLLEADPIKRIRIGEAKRVLQCLL SgK269_Hsap PFDENPELKEREYTRADLPRIPFRSPYSRGLQQLASCLLNPNPSERILISDAKGILQCLL SgK223_Mmus PFEVRAQLRERDYRREDLPPLPTLSLYSPGLQQLAHLLLEADPIKRIRIGEAKRVLQCLL SgK269_Mmus PFDENPELKEKEYTRTDLPRIPLRSPYSWGLQQLASCLLNPNPSERILISDAKGILQCLL Spk390_Spur PFSTRTSLIISDYTADDLPGIPVKSSLSADLRTIAAKLLAKNPQDRLTCNQAVSLLQCLL AqueK185_Aque PFDKDPQLVYKTYTHDDLPSISNEIKVSVYLETLTYLLLSRDPLKRLGLGDALLLTQSML **. ..* * *** :. * *. :: ** :* .*: .:* : *.:* SgK223_Hsap WGPRRELVQQPGTSEE--ALCGTLHNWIDMKRALMMMKFAEK------AVDRRRGVELED SgK269_Hsap WGPREDLFQTFTACPSLVQRNTLLQNWLDIKRTLLMIKFAEK------SLDREGGISLED SgK223_Mmus WGPRRELVEQPCTSEE--VLCNTLHNWIDMKRALMMMKFAEK------AVDRRRGVELED SgK269_Mmus WGPREDLFQIFTTSATLAQKNALLQNWLDIKRTLLMIKFAEK------SLDREGGISLED Spk390_Spur WGPPSTVYTDNANTAE--ALNQELERWLVAEQAKMVTKVALYSLLGRASSDNKSGLTLSD AqueK185_Aque WLPHSWLECSLPK--------TDIENHLLFLKGKTIAQIA--------QQDAQDLLALET * * : :.. : : : :.* * . : *. SgK223_Hsap WLCCQYLASAEPGALLQSLKLLQL---------------L SgK269_Hsap WLCAQYLAFATTDSLSCIVKILQH---------------R SgK223_Mmus WLCCQYLASAEPGALLQSLKLLQL---------------L SgK269_Mmus WLCAQYLAFATTDSLSYIVKILQY---------------R Spk390_Spur QLQCQYLSDSTVDTCKEAMRMLHGKNESETVNVIDSDLDL AqueK185_Aque VLKADFLATCDSSRLVRALAVMNNK-----MNEQRSSKSQ * .::*: . . : :::