CLUSTAL W (1.83) multiple sequence alignment PDK1_Hsap MARTTSQLYDAV------------------------------------------------ Pk61C_Dmel MAKEKASATVSL-GESNFRD------INLKDLAVVVEAASRLHHQQNVCGCGAV--S-ST PDK1_Mmus MARTTSQLYDAV------------------------------------------------ pdk-1_Cele MEDLTPTNTSL-------------------------------------DT------T-TT PKH2_Scer MYFDKDNSMSP-----RPLLPSDEQKLNINLLT-KKEKFSHL--DPHYDAKATPQ-RSTS PKH1_Scer MGNRSLTEADHALLS-KPLVPTSAE-------------------HTQTQEYPRPF-VDGS W04B5.5_Cele MEVPENLK---------------------------------------------------- YDR466W_Scer MTSR-------------------------------------------------------- Pdk1A_Ddis MENIVITNTSGG------------------------------------GGGGV------- Pdk1B_Ddis MINGRYQKEDVVNNN-NN--------LNLNLIEKTLNDLT-IKNNTNINNNNTNNK---- 8643_Tthe MIAKQIHEIEFAQIK-LFI-Q--------------------I--H-------------QS PDK1_Spur MPSLSTQSSKTS-LS----WPGHPMAAGSYMLQAAQEPIL--VTHTNFQGTAPPSRS-CS CC1G_15192_Ccin MSVKAAT----------------------------------------------------- AqueK012_Aque MAAPQEPP---------------------------------------------------- PDK1-2_Smoe MAAGEEECA-----------PST----------------------------------A-- PDK1-1_Smoe MAAGEEECA-----------PST----------------------------------A-- GK002_Glam MPFEQQS----------------------------------------------------- * PDK1_Hsap ------------------------------------------------------------ Pk61C_Dmel ENNN-------------------------------------------------------- PDK1_Mmus ------------------------------------------------------------ pdk-1_Cele NNDT-------------------------------------------------------- PKH2_Scer NRNVGDLLLEKRTAKPMIQKALTNTDNFIEMY---------------------------- PKH1_Scer NSQSGS-ELQASPQGQFGEKALTSTNRFIPLA---------------------------- W04B5.5_Cele ------------------------------------------------------------ YDR466W_Scer ------------------------------------------------------------ Pdk1A_Ddis ------------------------------------------------------------ Pdk1B_Ddis ----------------------------NTNYYNNNNFNNNNNNNNNNNNNNNNINNNNN 8643_Tthe N-----------------------TNKFYS------------------------------ PDK1_Spur ANSD-------------------------------------------------------- CC1G_15192_Ccin ------------------------------------------------------------ AqueK012_Aque ------------------------------------------------------------ PDK1-2_Smoe ------------------------------------------------------------ PDK1-1_Smoe ------------------------------------------------------------ GK002_Glam ------------------------------------------------------------ PDK1_Hsap ------------------------------------------------------------ Pk61C_Dmel ---------------------------------------------------------N-- PDK1_Mmus ------------------------------------------------------------ pdk-1_Cele ---------------------------------------------------------T-- PKH2_Scer -------------------------------------------------------HNQ-- PKH1_Scer ------------------------------------------------------------ W04B5.5_Cele ------------------------------------------------------------ YDR466W_Scer ------------------------------------------------------------ Pdk1A_Ddis ------------------------------------------------------------ Pdk1B_Ddis NNKYLNNSHNNNNNNNNNNNNNNNNNNNNNNNEINNNNNNVLSHSSLSGKGGSTTY---- 8643_Tthe ------------------------------------------------------------ PDK1_Spur ---------------------------------------------------------RAR CC1G_15192_Ccin ------------------------------------------------------------ AqueK012_Aque ------------------------------------------------------------ PDK1-2_Smoe ------------------------------------------------------------ PDK1-1_Smoe ------------------------------------------------------------ GK002_Glam ------------------------------------------------------------ PDK1_Hsap ------------------------------------------------------------ Pk61C_Dmel ------------------------------------------------------------ PDK1_Mmus ------------------------------------------------------------ pdk-1_Cele ------------------------------------------------------------ PKH2_Scer ------------------------------------------------------------ PKH1_Scer ------------------------------------------------------------ W04B5.5_Cele ------------------------------------------------------------ YDR466W_Scer ------------------------------------------------------------ Pdk1A_Ddis ------------------------------------------------------------ Pdk1B_Ddis ---------ETTSYTTSITSSRDTGT---------------------------------- 8643_Tthe ------------------------------------------------------------ PDK1_Spur STASGHARSPTTDRTFSHTSTRNTSNGTHYRCFCTAAVLCSLLAVSLLIAGLVFLLDGVA CC1G_15192_Ccin ------------------------------------------------------------ AqueK012_Aque ------------------------------------------------------------ PDK1-2_Smoe ------------------------------------------------------------ PDK1-1_Smoe ------------------------------------------------------------ GK002_Glam ------------------------------------------------------------ PDK1_Hsap ------------------------------------------------------------ Pk61C_Dmel ------------------------------------------------------------ PDK1_Mmus ------------------------------------------------------------ pdk-1_Cele ------------------------------------------------------------ PKH2_Scer -----------------------------QR-----KNLDDDTIKEVMINDENGKTVAST PKH1_Scer -------------------------------------------------NDDP------- W04B5.5_Cele ------------------------------------------------------------ YDR466W_Scer ------------------------------------------------------------ Pdk1A_Ddis ------------------------------------------------------------ Pdk1B_Ddis ------------------------------------------------------------ 8643_Tthe ------------------------------------------------------------ PDK1_Spur STSRTMGIILVVVATLVTICALVIWRYTCQRHKIVKETQQDVTLKSVKSN---------- CC1G_15192_Ccin ------------------------------------------------------------ AqueK012_Aque ------------------------------------------------------------ PDK1-2_Smoe ------------------------------------------------------------ PDK1-1_Smoe ------------------------------------------------------------ GK002_Glam ------------------------------------------------------------ PDK1_Hsap --------------------------------------PIQSSVVLCSCPSPSMV----- Pk61C_Dmel ------------------------------------------------------S----- PDK1_Mmus --------------------------------------PIQSSVVLCSCPSPSMV----- pdk-1_Cele ------------------------------------------------------S----- PKH2_Scer NDGR---------------YDNDYD-----NND------I-------------------- PKH1_Scer ------------------------------------------------------------ W04B5.5_Cele ------------------------------------------------------------ YDR466W_Scer ------------------------------------------------------------ Pdk1A_Ddis --------------------------------------PSS------STDPPNN------ Pdk1B_Ddis --------------------------------------IST------SYESS-------- 8643_Tthe ------------------------------------------------------FNDDLQ PDK1_Spur NSPSYVTKSICSNFKSSSFVL--REMASVNSAEFSECKPIIHSPVSRSCHQEAMS----- CC1G_15192_Ccin ------------------------------------------------------------ AqueK012_Aque ------------------------------------------------------------ PDK1-2_Smoe ------------------------------------------------------------ PDK1-1_Smoe ------------------------------------------------------------ GK002_Glam ------------------------------------------------------------ PDK1_Hsap ------RTQTES--ST---PPGIPG--G-S--RQGPAMDGTAA----------------- Pk61C_Dmel ------RYGSSKYLTNGHTSPLAAA--V-A--SNSSS-VATTP---HCRMLHNCSLQQYQ PDK1_Mmus ------RSQTEP--GS---SPGIPS--GVS--RQGSTMDGTTA----------------- pdk-1_Cele ------DREAAP--TTL---NLTPT--A-S--ESENS----------------------- PKH2_Scer ------NDQKTL--DN---IAGSPH--M-EKNRNKVKIEHDSS----------------- PKH1_Scer ---------GMQ--HE---MGLDPS--M-RRRREEWAERGAAKIVKD------------- W04B5.5_Cele ------------------------------------------------------------ YDR466W_Scer ------------------------------------------------------------ Pdk1A_Ddis -----------------------------T----TTT-TATAS-----AI---------- Pdk1B_Ddis -----------------------------S----SSS-SSSSS-----SL-YD---DDEY 8643_Tthe IFTLSVREKKQE--FS---IKMNQG--I-R--RSKRYCKVETK----------------- PDK1_Spur ------KHKSTD--SQ---PISSSGNSGSS--SKASN-NQFAS----------------- CC1G_15192_Ccin ------------------------------------------------------------ AqueK012_Aque ------------------------------------------------------------ PDK1-2_Smoe ------------------------------------------S----------------- PDK1-1_Smoe ------------------------------------------S----------------- GK002_Glam ------------------------------------------------------------ PDK1_Hsap ---------------------------------------------------EPRPGAG-- Pk61C_Dmel NDIRQQTEILDMLRQQHQQGYQSQQQ-------------------------QQQPQQQQE PDK1_Mmus ---------------------------------------------------EARPSTN-- pdk-1_Cele ----------------------------------------------------LSPVTA-- PKH2_Scer ---------------------------------------------------SQKPI---- PKH1_Scer ---------------------------------------------------VVDPA---- W04B5.5_Cele -----------------------------------------------------NPQ---- YDR466W_Scer ------------------------------------------------------------ Pdk1A_Ddis -----------------------------------------------DLNMSLSPFLSS- Pdk1B_Ddis SDYSDSSDSIDS-YVNHRQALSKSQQQQHLQQQQDQPQPLHSSMGAISNEKPPSPTNQQQ 8643_Tthe ---------------------------------------------------RIKKSDQ-- PDK1_Spur ---------------------------------------------------S--PRSA-- CC1G_15192_Ccin ------------------------------------------------------------ AqueK012_Aque ------------------------------------------------------------ PDK1-2_Smoe ---------------------------------------------------SCKPG---- PDK1-1_Smoe ---------------------------------------------------SCKPG---- GK002_Glam ------------------------------------------------------------ PDK1_Hsap -----------------SL----QHAQPPPQPRKKRPEDFKFGKILGEGSFSTV------ Pk61C_Dmel QQQQQ----------EQSQ----QQQQLQNPAPRRSPNDFIFGRYIGEGSYSIV------ PDK1_Mmus ---------------PLQQ----HPAQLPPQPRKKRPEDFKFGKILGEGSFSTV------ pdk-1_Cele ----------------EDL----IAKSIKEGCPKRTSNDFMFLQSMGEGAYSQV------ PKH2_Scer -----------------AK----ESSKAQKNIIKKGIKDFKFGSVIGDGAYSTV------ PKH1_Scer ------------------------TGELTKHVVKMGIKDFKFGEQLGDGSYSSV------ W04B5.5_Cele -------------------------NARREGSNMKCLADYSVEKEVGEGSFSTV------ YDR466W_Scer ---------------------------------KRSPHDFIFKEELGHGSYSTV------ Pdk1A_Ddis ---------------P--S----LSSPSIQSAKKKTIEDFIIGKVLGEGSYGAV------ Pdk1B_Ddis Q--QQHHHPKHNIELP--KTSSFGLQPNSSIPHKKSRSDFDFIRTIGKGAYGKV------ 8643_Tthe ---------------LTNF----NLSKHGWQAAILRNQLFSNNKNLGRGSFGEV------ PDK1_Spur ----------------TSP----SPSPSSTSILKKKRADFRFGTILGEGSYSEV------ CC1G_15192_Ccin -----------------------------VQRQPACLDDFDVGEEIAWGSLATI------ AqueK012_Aque -----------------KL----EAKSPPAEPQKKSREDFNFDRIIGEGSYSTV------ PDK1-2_Smoe -----------------SK----LTFRA--PQQPYTYQDFAYGRLLGMGSYSKV------ PDK1-1_Smoe -----------------SK----LTFRA--PQQPYTYQDFAYGRLLGMGSYSKVANSSCI GK002_Glam --------------------------------TTGDFPGFDVIDFLGEGSYGKV------ : :. *: . : PDK1_Hsap ------------VLARELA----TSREYAIKILEKRHIIKENKVPYVTRERDVMSRL--- Pk61C_Dmel ------------YLAVDIH----SRREYAIKVCEKRLILRERKQDYIKREREVMHQMT-- PDK1_Mmus ------------VLARELA----TSREYAIKILEKRHIIKENKVPYVTRERDVMSRL--- pdk-1_Cele ------------FRCREVA----TDAMFAVKVLQKSYLNRHQKMDAIIREKNILTYLSQE PKH2_Scer ------------MLATSIDT----KKRYAAKVLNKEYLIRQKKVKYVSIEKTALQKLN-- PKH1_Scer ------------VLATARDS----GKKYAVKVLSKEYLIRQKKVKYVTVEKLALQKLN-- W04B5.5_Cele ------------YLARRKEPKNDENPEVALKICLKRLILKNKMVPYIHREKEALALISRE YDR466W_Scer ------------FKALDKKS---PNKIYAIKVCSKKHIIKEAKVKYVTIEKNTMNLLAQ- Pdk1A_Ddis ------------VLGTEKE----TQQQYAIKILEKKQIIKENKIKYVQIEKEIFCKS--- Pdk1B_Ddis ------------KLVIEKE----TQLIFASKILNKKLIIKEKKAKYVNTEKTILDSL--- 8643_Tthe ------------ILAKNKS----NNEFCAIKILEKSYLAREKKQYQVFIEKEVLTHI--- PDK1_Spur ------------VLATEIA----TGNQYAIKVLEKRHIIREKKEKYVLREKEVLSRL--- CC1G_15192_Ccin ------------VEGVHKK----SGKLFAIKMLNKMQLSKKKMVRSAMLEKDALIALSS- AqueK012_Aque ------------SSC------------ALVKILDKRHIIKEKKVQYVSREKDVLARI--- PDK1-2_Smoe ------------VRAKKKDS----GAEFALKIMDKKHITKENKVAYVKMERLILDHL--- PDK1-1_Smoe FPFFIFLPLFQVVRAKKKDS----GAEFALKIMDKKHITKENKVAYVKMERLILDHL--- GK002_Glam ------------YRAIDAE----TGLEVGLKVINRKALENDKLLYTLDREVVALRTAQN- *: : : .. * : PDK1_Hsap --DHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKI--GSFDETCTRFYTAEIVSAL Pk61C_Dmel --NVPGFVNLSCTFQDQRSLYFVMTYARKGDMLPYINRV--GSFDVACTRHYAAELLLAC PDK1_Mmus --DHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKI--GSFDETCTRFYTAEIVSAL pdk-1_Cele CGGHPFVTQLYTHFHDQARIYFVIGLVENGDLGESLCHF--GSFDMLTSKFFASEILTGL PKH2_Scer --NSPSVVRLFSTFQDESSLYFLLEYAPNGDFLSLMKKY--GSLDETCARYYAAQIIDAI PKH1_Scer --GTKGIFKLFFTFQDEASLYFLLEYAPHGDFLGLIKKY--GSLNETCARYYASQIIDAV W04B5.5_Cele ENAHPGIVTLYATFQDSESLYFVLEYAKYGDLCTLMQKQPDSKFNVADSRYYAANLLSAL YDR466W_Scer -KHHAGIIKLYYTFHDEENLYFVLDFAPGGELLSLLHKM--GTFNDIWTRHFTAQLIDAL Pdk1A_Ddis --NHPNIVKLFFTFRSEQCLYYVLELCSQGDLLHQIKKV--GSFDYRSCQYYVAEIISGL Pdk1B_Ddis --DNPNIVKLFYTFQDENNLYFILEYCPNGDLLGALKKA--GCFSIDVVRFYAAEILIAL 8643_Tthe --RFDGIIQLLGSFKDNQFLYFVLEYCEGGEFSSYLQHNF-KFLNQDTIKFYAAEIVYIL PDK1_Spur --DHPFFVRLYFTFQDNYKLYFGLSLAKRGELLPYIKKL--GSFDESSSRFYTSEIILAL CC1G_15192_Ccin -HPHPGIVRLHYCFQDAANLYFVLDLAPNGDLKSLTLKT--GSLSLECARYYTAQMIDAI AqueK012_Aque --DHPFFVKLYFTFQDKDNLYFGLSFAEQGELLDYLRKV--GAFDENATRFYTSEIVIAL PDK1-2_Smoe --DHPGVVRLFFTFQDTHNLYMGLECCHGGELFDQIRRK--GRLSLEEARFYAAEIVDVL PDK1-1_Smoe --DHPGVVRLFFTFQDTHNLYMGLECCHGGELFDQIRRK--GRLSLEEARFYAAEIVDVL GK002_Glam -KNLTNIIRLYSKTDKNDFTTLILEYASLGDLSSLIKCY--RVLPEDWTRFLIAEIILGL . * . : *:: : :. :::: PDK1_Hsap EYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPES------------------- Pk61C_Dmel EHMHRRNVVHRDLKPENILLDEDMHTLIADFGSAKVMTAHERALATEHCS----EQRR-- PDK1_Mmus EYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPES------------------- pdk-1_Cele QFLHDNKIVHRDMKPDNVLIQKDGHILITDFGSAQAFGGLQLSQEGFTDA----NQAS-- PKH2_Scer DYLHSNGIIHRDIKPENILLDGEMKIKLTDFGTAKLLNPTNNSV---------------- PKH1_Scer DSLHNIGIIHRDIKPENILLDKNMKVKLTDFGTAKILPEEPSNTA--------------- W04B5.5_Cele EHIHKLGIIHRDVKADNLLVKSDGRIMLTDFGSSKFLSDYQKIQE--------------- YDR466W_Scer EFIHSHGIIHRDLKPENVLLDRDGRLMITDFGAAATIDPSLSGDSAK------------- Pdk1A_Ddis EHLHSLGIVHRDLKPENILMSSDLHVKITDFGTGKILPPPQSSQQQQQQQ----QQQQ-- Pdk1B_Ddis EYLHGKGIAHRDLKPENILLGKNQHLKLSDFGSAKQLSIGSHH----------------- 8643_Tthe ENLHKNGIIHRDLKPENLMLTKDNHLKIIDFGTCGFDRRIPEDLFQKINN----IKK--- PDK1_Spur EYLHSMGIIHRDLKPENILLNEKMHIQITDFGTAKIIGADDK------------------ CC1G_15192_Ccin NLMHEAGVAHRDIKPENCLLDKSMRIKIADFGSAYVTSTPL------------------- AqueK012_Aque EYLHGKGIIHRDLKPENILLNKDMHIQITDFGTAKIFESDE------------------- PDK1-2_Smoe EYIHGQGLIHRDLKPENLLLTADGHIKVADFGSAKVTTPLQNGL---------------- PDK1-1_Smoe EYIHGQGLIHRDLKPENLLLTADGHIKVADFGSAKVKYLSFSCSFLV------------- GK002_Glam EGLHSIGYCHRDIKPSNILLTRGGHVRIADFGTSKQLPLDEVSMAIGTKSFPPSAYMSTS : :* ***:*..* :: : : ***: PDK1_Hsap ------------------------------------------------------------ Pk61C_Dmel --S---NSDEDDEDSDRLEN-----EDEDFYDRDSEELDDGDDEQQQEEMDSPR------ PDK1_Mmus ------------------------------------------------------------ pdk-1_Cele --S--RSSDSGSPPPT------------RF---------------------YS------- PKH2_Scer ----------------------------------------------------S------- PKH1_Scer ---------------------------------------------------DG------- W04B5.5_Cele ---------------------------------------------------NP------- YDR466W_Scer --F------------------------------------------------NS------- Pdk1A_Ddis --Q--LPTNSSGNLSSLLNNVNNLSVSTDLTQQQQNRTSSVDSASTTDSMI--SPNLQPT Pdk1B_Ddis ------------------------------------------------------------ 8643_Tthe --KFPQET-------------------------------------------DP------- PDK1_Spur ------------------------------------------------------------ CC1G_15192_Ccin ------------------------------------------------------------ AqueK012_Aque ------------------------------------------------------------ PDK1-2_Smoe ------------------------------------------------------------ PDK1-1_Smoe --S------------------------------------------------FS------- GK002_Glam SAA--ASNDSQGTLQ------------------------------------KK------- PDK1_Hsap -----------------------------------------------------KQARANS Pk61C_Dmel ----------------------------------------------HRQR-RYNRHRKAS PDK1_Mmus -----------------------------------------------------KQARANS pdk-1_Cele -----------------------------------------------DEE-EENTARRTT PKH2_Scer -----------------------------------------------KPE-YDLSTRSKS PKH1_Scer -----------------------------------------------KPY-FDLYAKSKS W04B5.5_Cele -----------------------------------------------VEE-EQPTGRRSS YDR466W_Scer -----------------------------------------------DSNGSKDNQNCAS Pdk1A_Ddis TTTTNNNNNNNNNNNNNNNNTAAGSNTNTNTNTNINTNINANINNIKTT-EIPKLTRNNS Pdk1B_Ddis -----------------------------------------------------KGSRSGS 8643_Tthe -----------------------------------------------MDD-EDSRTRSST PDK1_Spur ---------------------------------------------------KEGQPRAKS CC1G_15192_Ccin -----------------------------------------------------STPKTNT AqueK012_Aque ------------------------------------------------------DEKASS PDK1-2_Smoe ------------------------------------------------SD-AQADDKSCT PDK1-1_Smoe -----------------------------------------------VHF-RFTDDKSCT GK002_Glam -----------------------------------------------LQN-M-DQQPRCS : PDK1_Hsap FVGTAQYVSPELLTEKSAC-KSSDLWALGCIIYQLVAGLPPFRAG--------------- Pk61C_Dmel FVGTAQYVSPEVLQNGPIT-PAADLWALGCIVYQMIAGLPPFRGS--------------- PDK1_Mmus FVGTAQYVSPELLTEKSAC-KSSDLWALGCIIYQLVAGLPPFRAG--------------- pdk-1_Cele FVGTALYVSPEMLADGDVG-PQTDIWGLGCILFQCLAGQPPFRAV--------------- PKH2_Scer FVGTAEYVSPELLNDSFTD-YRCDIWAFGCILFQMIAGKPPFKAT--------------- PKH1_Scer FVGTAEYVSPELLNDNYTD-SRCDIWAFGCILYQMLAGKPPFKAA--------------- W04B5.5_Cele FVGTAFFVTPELLTGSEMS-PSSDLWAFSVTLYLFLTGIYPFNDM--------------- YDR466W_Scer FVGTAEYVSPELLLYNQCG-YGSDIWALGCMIYQFVQGQPPFRGE--------------- Pdk1A_Ddis FVGTAEYVSPELISNKETS-TDSDLWALGCIIYQMASGRVPFRGK--------------- Pdk1B_Ddis FCGTAEYVCPELLTEKSAG-VEADIWSYGCLLYQLVSGKLPFKGF--------------- 8643_Tthe FVGTAEYVSPELLEGEICT-SSADLWALGCIIYRMFVGNTPFVDVND----------ATN PDK1_Spur FVGTAQYVSPELLTEKSAT-KSSDLWALGCIVYQLQAGLPPFRAS--------------- CC1G_15192_Ccin FVGTAAFLSPEVLLRQEANPRGPDLWAVGACLFFYLFGTYPFSAM--------------- AqueK012_Aque FVGTAEYVSPELLQSKVAY-KSSDLWALGCIIYQFLAGRPPFHAAYVNYTCSPPLFIMCR PDK1-2_Smoe FVGTAEYVSPEVLNGHPVT-IGADLWALGCIIYQMLEGRPPFKGG--------------- PDK1-1_Smoe FVGTAEYVSPEVLNGHPVT-IGADLWALGCIIYQMLEGRPPFKGG--------------- GK002_Glam IYGTVCYNAPESNRHGLLYMSPQDVWGLGCILYECLTGMPAFMGD--------------- : **. : ** *:*. . :: * .* PDK1_Hsap NEYLIFQKIIKLEYDFP---------EKFF-PKARDLVEKLLVLDATKRLGCEE--MEGY Pk61C_Dmel NDYVIFKEILDCAVDFP---------QGFD-KDAEDLVRKLLRVDPRDRLGAQDE-FGYY PDK1_Mmus NEYLIFQKIIKLEYHFP---------EKFF-PKARDLVEKLLVLDATKRLGCEE--MEGY pdk-1_Cele NQYHLLKRIQELDFSFP---------EGFP-EEASEIIAKILVRDPSTRITSQ------- PKH2_Scer NEYLTFQKVMKVQYAFT---------PGFP-LIIRDLVKKILVKNLDRRLTI-------- PKH1_Scer NEYLTFQKVMKIQYAFT---------AGFP-QIVKDLVKKLLVRDPNDRLTI-------- W04B5.5_Cele SEYLVFRRIQDILYTFS---------EDFPDENAKNLIERLLVKEQKSRLTSQ------- YDR466W_Scer NELKTFEKIVALDYPWGPNNRINNSTSPIN-PLVINLVQKILVIEVNERISL-------- Pdk1A_Ddis TEFLTFQKVSNRELVYP---------INMN-PVIKDLVEKLLVIKPTDRLGSSST-PGGF Pdk1B_Ddis NEYQTFLLITKREFSYP---------DNFD-KCCMNLIDQLLDLDPYKRPTI-------- 8643_Tthe NEFKVFNKVKACQYYIP---------DSVP-PEAADLIKNLLKRNPFERIGGGEPGVNDI PDK1_Spur NEYMIFQKIIKLEYDFP---------DGFS-QTARDLVSKLLVIDPSKRLGCDE--CGGY CC1G_15192_Ccin TDYLIMERIKKLDYKIP---------EGCD-PDAADLIKRLLVHHPQERLGVPP--NSSI AqueK012_Aque NEYLCFQKIIKHEYSIP---------DGFP-DNAKDLVENLLVSDPTKRLGCDK--MGGY PDK1-2_Smoe SEYLTFQKVLAKDLVIP---------SHFP-SAAKELINKLLNLEPDKRPGAGP---AGY PDK1-1_Smoe SEYLTFQKVLAKDLVIP---------SHFP-SAAKELINKLLNLEPDKRPGAGP---AGY GK002_Glam VELAIMQAIEKQKVIVP---------KTVS-PDAADLIKRLLTKDPTKRFNG------GW : : : ::: .:* . * PDK1_Hsap GPLKAHPFFES---------V-TWEN--LHQQ-------T--PPKL-------------- Pk61C_Dmel ESIRAHPFFAG---------I-DWQT--LRQQ-------T--PPPI-------------- PDK1_Mmus GPLKAHPFFET---------I-TWEN--LHQQ-------T--PPKL-------------- pdk-1_Cele -ELMAHKFFEN---------V-DWVN--IANI-------K--PPVL-------------- PKH2_Scer SQIKEHHFFKD---------L-NFKDGSVWSK-------T--PPEI-------------- PKH1_Scer KQIKAHLFFHE---------V-NFEDGSVWDD-------N--PPEI-------------- W04B5.5_Cele -EIKEHKFFES---------I-DFEH--LEQL-------E--PPRI-------------- YDR466W_Scer EQIKRHPYFSK---------V-DWND--KIKIWRGIWQSQ--GQSLQQTTLGLPNIPQNI Pdk1A_Ddis DNLKAHPFFQD---------F-NWSS--LSNM-------SHPPPPI-------------- Pdk1B_Ddis SEIKNHEFFSS---------IQDWSS--IPSQ-------T--PPPI-------------- 8643_Tthe NTLKKHPFFKG---------I-NWLT--LSKQ-------A--APKR-------------- PDK1_Spur PALKAHPFLEG---------V-DWEN--LHEQ-------K--APVL-------------- CC1G_15192_Ccin DELRQHPFFVGSREDGKSGHI-DWDT--IWTV-------P--APEI-------------- AqueK012_Aque PPLKAHYFFTD---------V-NWDN--VQNE-------T--PPTL-------------- PDK1-2_Smoe TALKSHAFFSG---------I-EWLK--LRQS-------A--APGL-------------- PDK1-1_Smoe AALKSHAFFSG---------I-EWLK--LRQS-------A--APGL-------------- GK002_Glam RAIKKHPFFTEH-------NV-DFAN--LNNQ-------M--PPFN-------------- : * :: . : PDK1_Hsap ----------------------------------------------------------TA Pk61C_Dmel ----------------------------------------------------------YP PDK1_Mmus ----------------------------------------------------------TA pdk-1_Cele ----------------------------------------------------------HA PKH2_Scer ----------------------------------------------------------KP PKH1_Scer ----------------------------------------------------------QP W04B5.5_Cele ------------------------------------------------------------ YDR466W_Scer LPTRQLHVIDTPARSIQITKQKRKKPTKISNTTSSIVVWRKRLGISTGKDDLGTVPSTTP Pdk1A_Ddis ----------------------------------------------------------QP Pdk1B_Ddis ----------------------------------------------------------EQ 8643_Tthe ----------------------------------------------------------EI PDK1_Spur ----------------------------------------------------------KP CC1G_15192_Ccin ----------------------------------------------------------KP AqueK012_Aque ----------------------------------------------------------LP PDK1-2_Smoe ----------------------------------------------------------AP PDK1-1_Smoe ----------------------------------------------------------AP GK002_Glam -----------------------------------------------------------P PDK1_Hsap YLPAM------------------------------------------------------- Pk61C_Dmel YLPGV------------------------------------------------------- PDK1_Mmus YLPAM------------------------------------------------------- pdk-1_Cele YIPAT------------------------------------------------------- PKH2_Scer YKINAKSMQAMPSGSDRKLVK----KSVNTLGKSHLVTQRSA-S----SPSVEETTHSTL PKH1_Scer YKINAEAMKPLQKVSESDTTV--KMANLQLAGN------GHA-DTPLQAPAATSQEHSVI W04B5.5_Cele ------------------------------------------------------------ YDR466W_Scer AVTA--------------------------------------------------PNDT-- Pdk1A_Ddis PQEKIIFD-------GDELFS----PSL-------------DCTTPR-NNNVDENHQQNS Pdk1B_Ddis MVPQSPFP-------SPNSSLRLKKRSLS-VGSPINSSLTYLSQPPI-KP-LNLDNSNID 8643_Tthe CKQQT------------------------------------------------------- PDK1_Spur CTV--------------------------------------------------------- CC1G_15192_Ccin GPFKS------------------------------------------------------- AqueK012_Aque YLPST------------------------------------------------------- PDK1-2_Smoe SPSS-------------------------------------------------------- PDK1-1_Smoe SPSS-------------------------------------------------------- GK002_Glam SIVFS------------------------------------------------------- PDK1_Hsap -----------------------------------------------------SE--D-- Pk61C_Dmel -----------------------------------------------------SQ--D-- PDK1_Mmus -----------------------------------------------------SE--D-- pdk-1_Cele -----------------------------------------------------FG--E-- PKH2_Scer Y---NNNTHAS-----TESEISIKKRPTDERTAQILENARKGINNRKNQ-PG--KRTP-- PKH1_Scer SMTAATAAFN--------KDY-------------------------TSQ-PK--L--G-- W04B5.5_Cele ------------------------------------------------------------ YDR466W_Scer NVLTNTAAHSTANIALP---------------------------------PNSQS--NQV Pdk1A_Ddis C----N-------------NN---------------NNNNNNINNINNN-NN---SSS-- Pdk1B_Ddis Y----N-------------DF---------------ENNQ-IISNNNNNNNN---TTT-- 8643_Tthe -----------------------------------------------------DN--E-- PDK1_Spur -----------------------------------------------------VD--G-- CC1G_15192_Ccin -----------------------------------------------------N------ AqueK012_Aque -----------------------------------------------------TK--G-- PDK1-2_Smoe -----------------------------------------------------QG--G-- PDK1-1_Smoe -----------------------------------------------------QG--G-- GK002_Glam -----------------------------------------------------DL----- PDK1_Hsap -------------DE-D--CYGNYDN--------LLSQFGCMQVSSSSSSH-SLS-ASDT Pk61C_Dmel -------------E--D--FRSSYTV--PG--D-LEPGLDERQISRLLSAE-LGV-GSSV PDK1_Mmus -------------DE-D--CYGNYDN--------LLSQFGFMQVSSSSSSH-SLS-TVET pdk-1_Cele -------------P--E--YYSNI-----G--P-VEPGLDDRALFRLM--N-LGN-DASA PKH2_Scer -------------SG-A--ASAALAASAAL--TKKT--M---QSYPTSSS--KSSRSSSP PKH1_Scer -------------SK-S--STSVRSASNNT--DREVIQK---KVSKNRAS--VSSPSIST W04B5.5_Cele ------------------------------------------------------------ YDR466W_Scer KRAQLVAPNRIPPKV-P--VINDNVR--NKSIPRTKPNVP-PLQTSSIPQK-LSTSSASS Pdk1A_Ddis -------------NN-I--SNSNSNS--NS--SN------NLNISNG---N-LSTPRSSS Pdk1B_Ddis -------------TTTTTTTSANTSG--ST--NN------TLYFTSP---N-VTSPPTSM 8643_Tthe -------------D--D-----------------DINDF-----------A-PSSPQTPV PDK1_Spur -------------E--E--IHSEYY----------VDDFD-LELNPTSLSE-YLK-RIET CC1G_15192_Ccin -------------------------------------------------------P---- AqueK012_Aque -------------EA-G--MHSDYNM---------PSS-----TSEQDFEDRFLQ-CFGL PDK1-2_Smoe -------------GN-G--AESDDSE--NS--DWDLAHLG-GRVSRLDVSD-ASSPMSSS PDK1-1_Smoe -------------GN-G--AESDDSE--NS--DWDLAHLG-GRVSRLDVSD-ASSPMSSS GK002_Glam -------------Q--E---------------------FKHMKV-----------P---- PDK1_Hsap -GLPQRS---GS------------------------------------------------ Pk61C_Dmel -AMPVKR---S------------------------------------------------- PDK1_Mmus -SLPQRS---GS------------------------------------------------ pdk-1_Cele -SQPSTP---SN------------------------------------------------ PKH2_Scer -ATTSRPGTYKRTSS-------------TESKPFAKSPPLSASVLSSKVPMPPYTPPMSP PKH1_Scer -TSRGKD---NRSRS--------------------------------------------- W04B5.5_Cele ------------------------------------------------------------ YDR466W_Scer -ALSAPS---TEIRN--------------------------------------------- Pdk1A_Ddis -SSSSQ------------------------------------------------------ Pdk1B_Ddis -SSNNT--------PRYINPLPTQSTTTTTTKPAYSSTPS-STILKSTPPPPILSSCSSN 8643_Tthe -NTTSM------------------------------------------------------ PDK1_Spur HDRPH-S---PT------------------------------------------------ CC1G_15192_Ccin ----R-S---SR------------------------------------------------ AqueK012_Aque G-DPSKT---ES------------------------------------------------ PDK1-2_Smoe -NEPSSP---SAVLA--------------------------------------------- PDK1-1_Smoe -NEPSSP---SAVLA--------------------------------------------- GK002_Glam ----KIM---NS------------------------------------------------ PDK1_Hsap ------------------------------------------------------------ Pk61C_Dmel ------------------------------------------------------------ PDK1_Mmus ------------------------------------------------------------ pdk-1_Cele ------VEH--------------------------------------------------- PKH2_Scer PMTPYDTYQMTPPYTTKQQDYSDTAIAAPKPCISKQNVKNST------------------ PKH1_Scer ------------------------------------------------------------ W04B5.5_Cele ------------------------------------------------------------ YDR466W_Scer -----------------------------------QDLTHTL------------------ Pdk1A_Ddis ------------------------------------------------------------ Pdk1B_Ddis NLLGKSSNQQYQPFQFHQQQQQQQ--------QQQQRERSSTTTPSPTFLSNHHNQHQKN 8643_Tthe ------------------------------------------------------------ PDK1_Spur ------------------------------------------------------------ CC1G_15192_Ccin ------------------------------------------------------------ AqueK012_Aque ------------------------------------------------------------ PDK1-2_Smoe ------------------------------------------------------------ PDK1-1_Smoe ------------------------------------------------------------ GK002_Glam ------------------------------------------------------------ PDK1_Hsap --------N---IEQYIHDLD--------------------------------------- Pk61C_Dmel ------------------------------------------------------------ PDK1_Mmus --------N---IEQYIHDLD--------------------------------------- pdk-1_Cele --------R---GDPFVSEIA--------------------------------------- PKH2_Scer -DSPLMNKQDIQWSFYLKNINEHVLRTEKLDF---------------------------- PKH1_Scer --------SDAFWSRYLQNMDERVLLMKEVA----------------------------- W04B5.5_Cele ------------------------------------------------------------ YDR466W_Scer -DGR--NS-----------IDIHVLKQDYVFI-YGIPYEHEGPAMSLNSYNKIDNDLITS Pdk1A_Ddis ---------------------------------------------Q-------------- Pdk1B_Ddis LQ------------QSFSSID-------KSSFSTSS------PMSS-------------- 8643_Tthe ------------------------------------------------------------ PDK1_Spur --------R---DNK--------------------------------------------- CC1G_15192_Ccin --------A---ES---------------------------------------------- AqueK012_Aque --------K---AR---------------------------------------------- PDK1-2_Smoe ------------------------------------------------------------ PDK1-1_Smoe ------------------------------------------------------------ GK002_Glam --------D---QA---------------------------------------------- PDK1_Hsap ----------------------------------------------------SNS----F Pk61C_Dmel ----------------------------------------------------TAK----N PDK1_Mmus ----------------------------------------------------TNS----F pdk-1_Cele ---------------------------------------------------PRAN----S PKH2_Scer --------VTTNYDILEKKMLK-------------------------------------- PKH1_Scer ------------------------------------------------------------ W04B5.5_Cele ------------------------------------------------------------ YDR466W_Scer LVAQHKEELKNSESFLQVLTLKKSGMLSYKNTVMEGNDDQENKEHQMANIEDTDL----S Pdk1A_Ddis ---------------------------------------------------PT------- Pdk1B_Ddis ---------------------------------------------------PR-ILLKPT 8643_Tthe ------------------------------------------------------------ PDK1_Spur -----------------------------------------------------------Y CC1G_15192_Ccin ------------------------------------------------------------ AqueK012_Aque -----------------------------------------------------------S PDK1-2_Smoe ------------------------------------------------------------ PDK1-1_Smoe ------------------------------------------------------------ GK002_Glam -----------------------------------------------------------N PDK1_Hsap ELDLQFSEDEKRL--LLEKQAGGNPWHQFV------------------------------ Pk61C_Dmel SFDL--NDAEKLQ--RLEQQ-KTDKWHVFA------------------------------ PDK1_Mmus ELDLQFSEDEKRL--LLEKQAGGNPWHQFV------------------------------ pdk-1_Cele EAEK--NRAARAQ--KLEEQRVKNPFHIFT------------------------------ PKH2_Scer ----------LNGS-LLDPQLFGKPRHTFL-SQVARSGGEVTGFRNDPTMTAYSKTEDTY PKH1_Scer ----------LSTR-NLEDSPVG------L-ENVA-----LD------------------ W04B5.5_Cele ------------------------------------------------------------ YDR466W_Scer MYDFEFNEL-TRKGFLILEKYKNRIWFIS--L---------------------------- Pdk1A_Ddis --QRSGSS--GGS--RDGGSS-SNNISKWL-N---------------------------- Pdk1B_Ddis ELVLMDKDRKRNI--REQQQIDQYQWSRFLLP---------------------------- 8643_Tthe --------------------------RP-------------------------------- PDK1_Spur VVDL--TPAERKQ--RLERQGKENKWHRFV------------------------------ CC1G_15192_Ccin ------------------DKAEEELWAKFE------------------------------ AqueK012_Aque GTEQDIL--DREE--KLKQQASTSTWHPFV------------------------------ PDK1-2_Smoe ----------SAA--RLLDENVHEPWQKFL-F---------------------------- PDK1-1_Smoe ----------SAA--RLLDENVHEPWQKFL-F---------------------------- GK002_Glam MLNL--ID-------TSEYRSKDSPLRRFL-I---------------------------- PDK1_Hsap -----------------------------------------------------ENNLILK Pk61C_Dmel -----------------------------------------------------DGEVILK PDK1_Mmus -----------------------------------------------------ENNLILK pdk-1_Cele -----------------------------------------------------NNSLILK PKH2_Scer YSKNIIDLQLLEDDYRIEGGDLSELLTNRSGEGYKCNQNSSPMKDDDKSESNNKGSS-VF PKH1_Scer -YKNPLDI---------------------------------------------------- W04B5.5_Cele ------------------------------------------------------------ YDR466W_Scer -----------------------------------------------------PSYSTLS Pdk1A_Ddis -----------------------------------------------------NGENVIY Pdk1B_Ddis -----------------------------------------------------NDEIILA 8643_Tthe ----------------------------------------------------------LI PDK1_Spur -----------------------------------------------------EGNLILK CC1G_15192_Ccin -----------------------------------------------------EIHLIED AqueK012_Aque -----------------------------------------------------NGELIIK PDK1-2_Smoe -----------------------------------------------------EGETILA PDK1-1_Smoe -----------------------------------------------------EGETILA GK002_Glam -----------------------------------------------------PGENIIY PDK1_Hsap MGPVDK---------------RK-----------GLFARRRQLLLTE-GPHLYYV----- Pk61C_Dmel KGFVNK---------------RK-----------GLFARKRMLLLTT-GPRLIYI----- PDK1_Mmus MGPVDK---------------RK-----------GLFARRRQLLLTE-GPHLYYV----- pdk-1_Cele QGYLEK---------------KR-----------GLFARRRMFLLTE-GPHLLYI----- PKH2_Scer SGKIKKLFHPTSAAETLSSSDEK-----------TKYY-KRTIVMTSFGRFLVFAKRRQP PKH1_Scer -EPP---------------TDSA-----------GKFY-KKMFLITNLGRALVFVKRRSL W04B5.5_Cele ------------------------------------------------------------ YDR466W_Scer KIPFNA---------------VKSSTINNNENWVDCFFRARQLLE-E-KQILDKI----- Pdk1A_Ddis QGLVWK---------------RK-----------GFSIKKRQLILTD-TPRLIYI----- Pdk1B_Ddis CGITEK---------------RS-----------GLITKKRQLIITD-TPRIFYV----- 8643_Tthe TGRVLK---------------KVA----------WLIYKPRQLILQEEPPKLVYY----- PDK1_Spur NGWVDK---------------RK-----------GLFARRRMLLLTE-GPHLYYV----- CC1G_15192_Ccin ------------------------------------------------------------ AqueK012_Aque TGLVDK---------------RK-----------GMFSKRRQLILTD-APRLYYV----- PDK1-2_Smoe SSRVRK---------------FR-----------KLSVKKRQLILTD-RPRLFYV----- PDK1-1_Smoe SSRVRK---------------FR-----------KLSVKKRQLILTD-RPRLFYV----- GK002_Glam SIDVVK---------------RRV----------LRLPKQRRFVLTD-FPRLFYI----- PDK1_Hsap D----------------------------------------------------------- Pk61C_Dmel D----------------------------------------------------------- PDK1_Mmus D----------------------------------------------------------- pdk-1_Cele D----------------------------------------------------------- PKH2_Scer N----------------------------------------------------------- PKH1_Scer ------------------------------------------------------------ W04B5.5_Cele ------------------------------------------------------------ YDR466W_Scer SNVSFDSKASSEPSSPPPISRKERPLSIGNNVTTLSYTAKNGSQNNAPQNDNVGEEKPFR Pdk1A_Ddis D----------------------------------------------------------- Pdk1B_Ddis D----------------------------------------------------------- 8643_Tthe D----------------------------------------------------------- PDK1_Spur D----------------------------------------------------------- CC1G_15192_Ccin ------------------------------------------------------------ AqueK012_Aque D----------------------------------------------------------- PDK1-2_Smoe H----------------------------------------------------------- PDK1-1_Smoe H----------------------------------------------------------- GK002_Glam D----------------------------------------------------------- PDK1_Hsap ------------------------------------------------------------ Pk61C_Dmel ------------------------------------------------------------ PDK1_Mmus ------------------------------------------------------------ pdk-1_Cele ------------------------------------------------------------ PKH2_Scer ------------------------------------------------------------ PKH1_Scer ------------------------------------------------------------ W04B5.5_Cele ------------------------------------------------------------ YDR466W_Scer IPSSTKDRPGANSTPSSRHPRVLSSNNAGETPKKMNGRLPNSAPSTNTYTNGSVPAFNHR Pdk1A_Ddis ------------------------------------------------------------ Pdk1B_Ddis ------------------------------------------------------------ 8643_Tthe ------------------------------------------------------------ PDK1_Spur ------------------------------------------------------------ CC1G_15192_Ccin ------------------------------------------------------------ AqueK012_Aque ------------------------------------------------------------ PDK1-2_Smoe ------------------------------------------------------------ PDK1-1_Smoe ------------------------------------------------------------ GK002_Glam ------------------------------------------------------------ PDK1_Hsap ------------------------PV-------------------NKVLKGEIPWSQ-EL Pk61C_Dmel ------------------------PV-------------------QMIKKGEIPWSP-DL PDK1_Mmus ------------------------PV-------------------NKVLKGEIPWSQ-EL pdk-1_Cele ------------------------VP-------------------NLVLKGEVPWTP-CM PKH2_Scer ------------------------PV-------------------T-NLKYELEYDI-NL PKH1_Scer -----------------------------------------------SMWEEQEFEL-QF W04B5.5_Cele ------------------------------------------------------------ YDR466W_Scer PSTNVGNNKHNILTSKKQGSSVFSPSSSTTKPQIKTTGYRQPTPSPPLPQMEFPTTR-EK Pdk1A_Ddis ------------------------PK-------------------KMELKGEIPWSD-SI Pdk1B_Ddis ------------------------PV-------------------KMTQKGEITVDG-SL 8643_Tthe ------------------------PM-------------------TNVKKGEIPLSK-NV PDK1_Spur ------------------------PE-------------------NMVLKGEIPWSP-QL CC1G_15192_Ccin ------------------------------------------------------------ AqueK012_Aque ------------------------PV-------------------AMVLKGEIPWSS-NI PDK1-2_Smoe ------------------------PI-------------------KLVFKGEVPWSR-DI PDK1-1_Smoe ------------------------PI-------------------KLVFKGEVPWSR-DI GK002_Glam ------------------------VS-------------------TMVQKGEIDMTSTNL PDK1_Hsap RP---------------------------------------------------------- Pk61C_Dmel RA---------------------------------------------------------- PDK1_Mmus RP---------------------------------------------------------- pdk-1_Cele QV---------------------------------------------------------- PKH2_Scer RQQG-------------------------------------------------------- PKH1_Scer ELEL-------------------------------------------------------- W04B5.5_Cele ------------------------------------------------------------ YDR466W_Scer YS---------------------------------------------------------- Pdk1A_Ddis KP---------------------------------------------------------- Pdk1B_Ddis SA---------------------------------------------------------- 8643_Tthe KI---------------------------------------------------------- PDK1_Spur KV---------------------------------------------------------- CC1G_15192_Ccin ------------------------------------------------------------ AqueK012_Aque KI---------------------------------------------------------- PDK1-2_Smoe YV---------------------------------------------------------- PDK1-1_Smoe YV---------------------------------------------------------- GK002_Glam KITRIGERTIEFTLGQNCFTAEVLTKDLCDLWLRYMTMYSVNGKTAMANIMANRANLVKV PDK1_Hsap ------------------------------------------------------------ Pk61C_Dmel ------------------------------------------------------------ PDK1_Mmus ------------------------------------------------------------ pdk-1_Cele ------------------------------------------------------------ PKH2_Scer ------------TKIK--------------------------------ELI--------- PKH1_Scer ------------NDVEKIR----------------------------FISD--------- W04B5.5_Cele ------------------------------------------------------------ YDR466W_Scer ------------------------------------------------------------ Pdk1A_Ddis ------------------------------------------------------------ Pdk1B_Ddis ------------------------------------------------------------ 8643_Tthe ------------------------------------------------------------ PDK1_Spur ------------------------------------------------------------ CC1G_15192_Ccin ------------------------------------------------------------ AqueK012_Aque ------------------------------------------------------------ PDK1-2_Smoe ------------------------------------------------------------ PDK1-1_Smoe ------------------------------------------------------------ GK002_Glam SDQDMRCEMCKGRLFK-NGFCNTCGNVAQVSNNGSSTIQYILKMDPRWLPVSEKEIRLHS PDK1_Hsap ------------------------------------------------------------ Pk61C_Dmel ------------------------------------------------------------ PDK1_Mmus ------------------------------------------------------------ pdk-1_Cele ------------------------------------------------------------ PKH2_Scer -------I---------------------------------------------------- PKH1_Scer -------Q---------------------------------------------------- W04B5.5_Cele ------------------------------------------------------------ YDR466W_Scer ------------------------------------------------------------ Pdk1A_Ddis ------------------------------------------------------------ Pdk1B_Ddis ------------------------------------------------------------ 8643_Tthe ------------------------------------------------------------ PDK1_Spur ------------------------------------------------------------ CC1G_15192_Ccin ------------------------------------------------------------ AqueK012_Aque ------------------------------------------------------------ PDK1-2_Smoe ------------------------------------------------------------ PDK1-1_Smoe ------------------------------------------------------------ GK002_Glam RLALISGIQPEMDNIEAMSRYETRSSVQKAIDRLKKTQEDVVVYKNRQDQPLDGSTTLPD PDK1_Hsap ----------------------------EAKN-----FKTFFVHT--------------- Pk61C_Dmel ----------------------------EYKN-----FKIFFVHT--------------- PDK1_Mmus ----------------------------EAKN-----FKTFFVHT--------------- pdk-1_Cele ----------------------------ELKN-----SGTFFIHT--------------- PKH2_Scer --------------------------PLEMGT-----NHIVVIQT--------------- PKH1_Scer --------------------------VLEIDG-----SRTIFIGC--------------- W04B5.5_Cele ------------------------------------------------------------ YDR466W_Scer ----------------------------APSNMVISSSRYEVLHT--------------- Pdk1A_Ddis ----------------------------KLKS-----NNNFVIKT--------------- Pdk1B_Ddis ----------------------------QQKS-----SKHFIINS--------------- 8643_Tthe ----------------------------ELQD-----KSRFTIVG--------------- PDK1_Spur ----------------------------EAKN-----FKTYFVHT--------------- CC1G_15192_Ccin ------------------------------------------------------------ AqueK012_Aque ----------------------------EQKN-----FKIFFVHT--------------- PDK1-2_Smoe ----------------------------RVEN-----DLKFCICT--------------- PDK1-1_Smoe ----------------------------RVEN-----DLKFCICT--------------- GK002_Glam QQSAISGPTVELTTQEAVQASSTLCATPELKE-----LQSGFVQSGQISQLSGTALLLNP PDK1_Hsap ------------------------------------------------------------ Pk61C_Dmel ------------------------------------------------------------ PDK1_Mmus ------------------------------------------------------------ pdk-1_Cele ------------------------------------------------------------ PKH2_Scer ------------------------------------------------------------ PKH1_Scer ------------------------------------------------------------ W04B5.5_Cele ------------------------------------------------------------ YDR466W_Scer ------------------------------------------------------------ Pdk1A_Ddis ------------------------------------------------------------ Pdk1B_Ddis ------------------------------------------------------------ 8643_Tthe ------------------------------------------------------------ PDK1_Spur ------------------------------------------------------------ CC1G_15192_Ccin ------------------------------------------------------------ AqueK012_Aque ------------------------------------------------------------ PDK1-2_Smoe ------------------------------------------------------------ PDK1-1_Smoe ------------------------------------------------------------ GK002_Glam PLATKPKPASEKDSAIYGTQFPNLPNMRRSSAECCLPSSANVDDEELQSDMYKDQARMSG PDK1_Hsap ------------------------------------------------------------ Pk61C_Dmel ------------------------------------------------------------ PDK1_Mmus ------------------------------------------------------------ pdk-1_Cele ------------------------------------------------------------ PKH2_Scer ------------------------------------------------------------ PKH1_Scer ------------------------------------------------------------ W04B5.5_Cele ------------------------------------------------------------ YDR466W_Scer ------------------------------------------------------------ Pdk1A_Ddis ------------------------------------------------------------ Pdk1B_Ddis ------------------------------------------------------------ 8643_Tthe ------------------------------------------------------------ PDK1_Spur ------------------------------------------------------------ CC1G_15192_Ccin ------------------------------------------------------------ AqueK012_Aque ------------------------------------------------------------ PDK1-2_Smoe ------------------------------------------------------------ PDK1-1_Smoe ------------------------------------------------------------ GK002_Glam ASTLSSITNRQSMSVQVISKQEKDLFEFFHANDSLINLEESGHVLPSSEQAARVSVDGKS PDK1_Hsap ----------------------------------------------------------PN Pk61C_Dmel ----------------------------------------------------------PN PDK1_Mmus ----------------------------------------------------------PN pdk-1_Cele ----------------------------------------------------------PN PKH2_Scer ----------------------------------------------------------PY PKH1_Scer ----------------------------------------------------------KE W04B5.5_Cele ------------------------------------------------------------ YDR466W_Scer ----------------------------------------------------------LN Pdk1A_Ddis ----------------------------------------------------------PK Pdk1B_Ddis ----------------------------------------------------------KG 8643_Tthe ----------------------------------------------------------PK PDK1_Spur ----------------------------------------------------------PN CC1G_15192_Ccin ------------------------------------------------------------ AqueK012_Aque ----------------------------------------------------------PN PDK1-2_Smoe ----------------------------------------------------------PK PDK1-1_Smoe ----------------------------------------------------------PK GK002_Glam YQDGGIMDGINQAHLDSIVQQVTLTSPLHTERNSASLITPPLNSCQYKYETPVYPQSSPN PDK1_Hsap RT----------------YYLM-------------------------------------- Pk61C_Dmel RT----------------YYLD-------------------------------------- PDK1_Mmus RT----------------YYLM-------------------------------------- pdk-1_Cele RV----------------YYLF-------------------------------------- PKH2_Scer KS----------------FLLS-------------------------------------- PKH1_Scer RA----------------VLMK-------------------------------------- W04B5.5_Cele ------------------------------------------------------------ YDR466W_Scer NS----------------QTNF-------------------------------------- Pdk1A_Ddis RK----------------YLLE-------------------------------------- Pdk1B_Ddis RS----------------RHFY-------------------------------------- 8643_Tthe KK----------------YFFK-------------------------------------- PDK1_Spur RT----------------YYLI-------------------------------------- CC1G_15192_Ccin ------------------------------------------------------------ AqueK012_Aque RT----------------YYLE-------------------------------------- PDK1-2_Smoe RT----------------YNLE-------------------------------------- PDK1-1_Smoe RT----------------YNLE-------------------------------------- GK002_Glam KAIPQKQSDLPTDIPGLLTYMDETPGHSVTPAVAPSGHASAVINKRDTLNSLQSMILGEF PDK1_Hsap ------------------------------------------------------------ Pk61C_Dmel ------------------------------------------------------------ PDK1_Mmus ------------------------------------------------------------ pdk-1_Cele ------------------------------------------------------------ PKH2_Scer ------------------------------------------------------------ PKH1_Scer --------------------------------------LWKLIHN-GMTAKPKVV----- W04B5.5_Cele ------------------------------------------------------------ YDR466W_Scer ------------------------------------------------------------ Pdk1A_Ddis ------------------------------------------------------------ Pdk1B_Ddis ------------------------------------------------------------ 8643_Tthe ------------------------------------------------------------ PDK1_Spur ------------------------------------------------------------ CC1G_15192_Ccin ------------------------------------------------------------ AqueK012_Aque ------------------------------------------------------------ PDK1-2_Smoe ------------------------------------------------------------ PDK1-1_Smoe ------------------------------------------------------------ GK002_Glam PELPTNVANQSSHIRITTASTQAILGSHSYSVRCLLAKIYAVSSAAELLPYPTLPLPRIL PDK1_Hsap ------------------------------------------------------------ Pk61C_Dmel ------------------------------------------------------------ PDK1_Mmus ------------------------------------------------------------ pdk-1_Cele ------------------------------------------------------------ PKH2_Scer ------------------------------------------------------------ PKH1_Scer ------------------------------------------------------------ W04B5.5_Cele ------------------------------------------------------------ YDR466W_Scer ------------------------------------------------------------ Pdk1A_Ddis ------------------------------------------------------------ Pdk1B_Ddis ------------------------------------------------------------ 8643_Tthe ------------------------------------------------------------ PDK1_Spur ------------------------------------------------------------ CC1G_15192_Ccin ------------------------------------------------------------ AqueK012_Aque ------------------------------------------------------------ PDK1-2_Smoe ------------------------------------------------------------ PDK1-1_Smoe ------------------------------------------------------------ GK002_Glam GYCGDRLLLQYRENIGVIGKFLTILYVLNNKQAILPPLGTTIVDKVEPHCICICQNERRV PDK1_Hsap ---D-------------------------------------------------------- Pk61C_Dmel ---D-------------------------------------------------------- PDK1_Mmus ---D-------------------------------------------------------- pdk-1_Cele ---D-------------------------------------------------------- PKH2_Scer ---T-------------------------------------------------------- PKH1_Scer ---S-------------------------------------------------------- W04B5.5_Cele ------------------------------------------------------------ YDR466W_Scer ---D-------------------------------------------------------- Pdk1A_Ddis ---D-------------------------------------------------------- Pdk1B_Ddis ---D-------------------------------------------------------- 8643_Tthe ---E-------------------------------------------------------- PDK1_Spur ---D-------------------------------------------------------- CC1G_15192_Ccin ------------------------------------------------------------ AqueK012_Aque ---D-------------------------------------------------------- PDK1-2_Smoe ---D-------------------------------------------------------- PDK1-1_Smoe ---D-------------------------------------------------------- GK002_Glam KLSDNIDTNYDVTIRHASPCYTCGGDVFKELPTGEIINDALLASLKSQQTSVTQIPTIVF PDK1_Hsap ------------------------------------------------------------ Pk61C_Dmel ------------------------------------------------------------ PDK1_Mmus ------------------------------------------------------------ pdk-1_Cele ------------------------------------------------------------ PKH2_Scer ------------------------------------------------------------ PKH1_Scer ------------------------------------------------------------ W04B5.5_Cele ------------------------------------------------------------ YDR466W_Scer ------------------------------------------------------------ Pdk1A_Ddis ------------------------------------------------------------ Pdk1B_Ddis ------------------------------------------------------------ 8643_Tthe ------------------------------------------------------------ PDK1_Spur ------------------------------------------------------------ CC1G_15192_Ccin ------------------------------------------------------------ AqueK012_Aque ------------------------------------------------------------ PDK1-2_Smoe ------------------------------------------------------------ PDK1-1_Smoe ------------------------------------------------------------ GK002_Glam PQGLSAANEKTTSKAPEVSGSVLVKRATMSNKKVSSVQLDDEIPLVSRDLNEEHSTNSYM PDK1_Hsap --------------------------------PS-------------------------- Pk61C_Dmel --------------------------------PE-------------------------- PDK1_Mmus --------------------------------PS-------------------------- pdk-1_Cele --------------------------------LE-------------------------- PKH2_Scer --------------------------------DK-------------------------- PKH1_Scer --------------------------------PK-------------------------- W04B5.5_Cele ------------------------------------------------------------ YDR466W_Scer --------------------------------RE-------------------------- Pdk1A_Ddis --------------------------------VA-------------------------- Pdk1B_Ddis --------------------------------LD-------------------------- 8643_Tthe --------------------------------LD-------------------------- PDK1_Spur --------------------------------PE-------------------------- CC1G_15192_Ccin ------------------------------------------------------------ AqueK012_Aque --------------------------------PT-------------------------- PDK1-2_Smoe --------------------------------TK-------------------------- PDK1-1_Smoe --------------------------------TK-------------------------- GK002_Glam AVFDKRRTSNTVCIQELDTESEECFETYKHFDTEPSVETAVPLSAGLKFYFHANGNTPVA PDK1_Hsap ------------------------------------------------------GNAHKW Pk61C_Dmel ------------------------------------------------------GYAIHW PDK1_Mmus ------------------------------------------------------GNAHKW pdk-1_Cele ------------------------------------------------------KKADEW PKH2_Scer ------------------------------------------------------KTTSKL PKH1_Scer ------------------------------------------------------SDHKMF W04B5.5_Cele ------------------------------------------------------------ YDR466W_Scer ---------------------IAS------------------------------RGASAA Pdk1A_Ddis ------------------------------------------------------HNPQKW Pdk1B_Ddis ------------------------------------------------------GQSKLW 8643_Tthe ------------------------------------------------------HPANIW PDK1_Spur ------------------------------------------------------SDAVEW CC1G_15192_Ccin ------------------------------------------------------------ AqueK012_Aque ------------------------------------------------------GSAKKW PDK1-2_Smoe ------------------------------------------------------GQARVW PDK1-1_Smoe ------------------------------------------------------GQARVW GK002_Glam LIPIAELSWLNIGASARYRKAIKEKVAEALTPLCCSHQRKPEVSLPGIMSIKQFQQKDKW PDK1_Hsap CRKIQEV----------WRQ-------------RY-----------Q------------- Pk61C_Dmel SEAIENM----------RKL-------------AY-----------G------------- PDK1_Mmus CRKIQEV----------WRQ-------------QY-----------Q------------- pdk-1_Cele CKAINDV----------RKR-------------YS-----------V------------- PKH2_Scer FTVLKKI----------LNS-------------NTNKIEKELLQRNQKVIERRTSSSGRA PKH1_Scer D----------------------------------------------------------- W04B5.5_Cele ------------------------------------------------------------ YDR466W_Scer FRSLQ------------------------------------------------------- Pdk1A_Ddis VDSIKSV----------ILS---------------------------------------- Pdk1B_Ddis VDLINEL----------NM----------------------------------------- 8643_Tthe VEKVSKL----------IKD-------------K-------------------------- PDK1_Spur CQAIKEM----------YRH-------------TY------------------------- CC1G_15192_Ccin ------------------------------------------------------------ AqueK012_Aque VETLNKS----------LVL---------------------------------------- PDK1-2_Smoe KESIE------------------------------------------------------- PDK1-1_Smoe KESIE------------------------------------------------------- GK002_Glam CKYLGANGSAFELTEEIYKVGKLQDLRFLLEMNTYH-------KQVSF------------ PDK1_Hsap ------------------------------------------------------------ Pk61C_Dmel ----DPSSTSAVSCSSGSSNSLAVISNSSAASSSNSPTVKRSSPV-----------NAPQ PDK1_Mmus ------------------------------------------------------------ pdk-1_Cele ----TIEKTFNSAMRDGTFGSIYGKKKS------------RKEMMREQKA-----LRRKQ PKH2_Scer IPKDLPTSKSPSPKPRTHSQSPSISKHNSFSESINSAKSNRSS------RIFETFINAKE PKH1_Scer -----------------------------------------------------KFILQKR W04B5.5_Cele ------------------------------------------------------------ YDR466W_Scer ------------------------------------------------------------ Pdk1A_Ddis ------------------------------------------------------------ Pdk1B_Ddis ------------------------------------------------------------ 8643_Tthe ------------------------------------------------------------ PDK1_Spur ------------------------------------------------------------ CC1G_15192_Ccin ------------------------------------------------------------ AqueK012_Aque ------------------------------------------------------------ PDK1-2_Smoe ------------------------------------------------------------ PDK1-1_Smoe ------------------------------------------------------------ GK002_Glam ----DVTIQYDE-SSDGYFNALYLDE------------CMRSSAVSATTA---------- PDK1_Hsap ------------------------------------------------------------ Pk61C_Dmel A--------ST------------------------------------------------- PDK1_Mmus ------------------------------------------------------------ pdk-1_Cele E----------------------------------------------------------- PKH2_Scer QNSKK--HAAPVPLTSKLVNGLPKRQV--------------------------------- PKH1_Scer QNTKKKNQAPPVPQSNRLINGLPDRCILKTPEEGALHTKRPTSLQT---RSS-------- W04B5.5_Cele ------------------------------------------------------------ YDR466W_Scer ------------------------------------------------------------ Pdk1A_Ddis ------------------------------------------------------------ Pdk1B_Ddis ------------------------------------------------------------ 8643_Tthe ------------------------------------------------------------ PDK1_Spur ------------------------------------------------------------ CC1G_15192_Ccin ------------------------------------------------------------ AqueK012_Aque ------------------------------------------------------------ PDK1-2_Smoe ------------------------------------------------------------ PDK1-1_Smoe ------------------------------------------------------------ GK002_Glam -----------------------------------------YTVEDLGTSTGTSIHNHNK PDK1_Hsap ------------------------------------------------------------ Pk61C_Dmel --ASDNRTL--------------------------------------------------G PDK1_Mmus ------------------------------------------------------------ pdk-1_Cele --KEEKKAL--------------------------------------------------K PKH2_Scer ---TVGLGL--------------------------------------------------N PKH1_Scer --SNYSKLL--------------------------------------------------A W04B5.5_Cele ------------------------------------------------------------ YDR466W_Scer ------------------------------------------------------------ Pdk1A_Ddis ------------------------------------------------------------ Pdk1B_Ddis ------------------------------------------------------------ 8643_Tthe ------------------------------------------------------------ PDK1_Spur ------------------------------------------------------------ CC1G_15192_Ccin ------------------------------------------------------------ AqueK012_Aque ------------------------------------------------------------ PDK1-2_Smoe ------------------------------------------------------------ PDK1-1_Smoe ------------------------------------------------------------ GK002_Glam PDTVYQHMVEDYTQSSFKLANRQPYIHYCRRCVCSECISKIEQKDCFIKLEAVEQKSAFI PDK1_Hsap ------------------------------------------------------------ Pk61C_Dmel S---------------------------------------------T------------- PDK1_Mmus ------------------------------------------------------------ pdk-1_Cele A---------------------------------------------EQV----------- PKH2_Scer ----------------------------------------------TG------------ PKH1_Scer ----------------------------------------------RS------------ W04B5.5_Cele ------------------------------------------------------------ YDR466W_Scer ------------------------------------------------------------ Pdk1A_Ddis ------------------------------------------------------------ Pdk1B_Ddis ------------------------------------------------------------ 8643_Tthe ------------------------------------------------------------ PDK1_Spur ------------------------------------------------------------ CC1G_15192_Ccin ------------------------------------------------------------ AqueK012_Aque ------------------------------------------------------------ PDK1-2_Smoe ------------------------------------------------------------ PDK1-1_Smoe ------------------------------------------------------------ GK002_Glam ASEFGKDEYSFELFKSWVSRRFPFQFREGNFPLRHRCRYEQCKRYVESIAPCGDVNLRLP PDK1_Hsap --------------------------SHPDAAVQ Pk61C_Dmel ----------------RT-----GTSPSKKTASK PDK1_Mmus --------------------------SNPDAAVQ pdk-1_Cele ----------------SK-----KLSMQMDKKSP PKH2_Scer ----------------TN-----FKNSSAKSKRS PKH1_Scer ----------------TQ-----MRKNMTRTDEK W04B5.5_Cele ---------------------------------Y YDR466W_Scer ----------------------------KSKKKK Pdk1A_Ddis -----------------------------SGSSN Pdk1B_Ddis ------------------------------LSFK 8643_Tthe ----------------------------FEDLKL PDK1_Spur ------------------------------QKSI CC1G_15192_Ccin ------------------------------EGRI AqueK012_Aque ----------------------------YKSQNK PDK1-2_Smoe ----------------------------KLVNAK PDK1-1_Smoe ----------------------------KLVNAK GK002_Glam FVTMARPADAEVMEVGTQIPTSAELDEYWVDFAT