CLUSTAL W (1.83) multiple sequence alignment PHKg2_Hsap MTL---DVGPEDE----LPDWAAAKEFYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVK PHKg1_Hsap MTR---D----EA----LPDSHSAQDFYENYEPKEILGRGVSSVVRRCIHKPTSQEYAVK PHKg2_Mmus MTL---DVGPEDE----LPDWAAAKEFYQKYDPKDIIGRGVSSVVRRCVHRATGDEFAVK PHKg1_Mmus MTR---D----DA----LPDSHSAQTFYENYEPKEILGRGVSSVVRRCIHKPTCQEYAVK Y50D7A.3_Cele MGMLIVDTDHEDSDESQHYRHEEDQGFNAAYESKEVLGRGLASTVRRCIEKGSGQHFAVK PHKG1_Spur MTV---DDNQDET----DFGIEYDDAFSSKYMAKHILGRGVSSTVRLCCNRNTNEEYAVK PhK__Dmel MAK---DE-EDDL----LPDKDAAKGFYAKYEPKEILGRGISSTVRRCIEKETGKEFAAK AqueK079_Aque MAD---S-GGSTS----FLQGTDEGEFHNKYEPKEILGRGLSSTVRRCVSRDTGLEYAVK * . * * .*.::***::*.** * : : .:*.* PHKg2_Hsap IMEVTAE-RLSPEQLEEVREATRRETHILRQVA---GHPHIITLIDSYESSSFMFLVFDL PHKg1_Hsap VIDVTGGGSFSPEEVRELREATLKEVDILRKVS---GHPNIIQLKDTYETNTFFFLVFDL PHKg2_Mmus IMEVSAE-RLSLEQLEEVRDATRREMHILRQVA---GHPHIITLIDSYESSSFMFLVFDL PHKg1_Mmus IIDITGGGSFSSEEVQELREATLKEVDILQKVS---GHPNIIQLKDTYETNTFFFLVFDL Y50D7A.3_Cele IVDISTE-KQSENEAKRLLEETISEVEILRQLS---GHPSIIKIHDFYQTPSFLFAVFEM PHKG1_Spur IIDITGQNHGGDNRAEAIQEEYRNEILILNKMAEGEGHPNIR------------------ PhK__Dmel IIDLGATTESGETNPYHMLEATRQEISILRQVM---GHPYIIDLQDVFESDAFVFLVFEL AqueK079_Aque IISRT--------QDEVINESIAAEIEVLNLLP---KHPNIIQLYDKFETPAYIFLVFEL ::. . : : * :*. : ** * PHKg2_Hsap MRKGELFDYLTEKVALSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENILLDDNMQIRL PHKg1_Hsap MKRGELFDYLTEKVTLSEKETRKIMRALLEVICTLHKLNIVHRDLKPENILLDDNMNIKL PHKg2_Mmus MRKGELFDYLTEKVALSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENILLDDNMQIRL PHKg1_Mmus MKRGELFDYLTEKVTLTEKETRKIMRALLEVICTLHKLNIVHRDLKPENILLDDNMNIKL Y50D7A.3_Cele APRGELFDVLNSTVTVSEKRARRLMKQLFDGVEYMHARDIVHRDLKLENILCIDEERIVI PHKG1_Spur ----ELFDYLTAVITLSEKKTRAIMRSVISAVAYIHSHNIVHRDLKPENILLDANLKVKI PhK__Dmel CPKGELFDYLTSVVTLSEKKTRTIMRQIFEGVEYIHAKSIVHRDLKPENILLDENHNVKI AqueK079_Aque ACGGELFDYLTKVVRLSEKKTRLIMQQVFSGVHHMHSSCVVHRDLKPENILLDKNGNVKI **** *. : ::**.:* :*: ::. : :* :****** **** : .: : PHKg2_Hsap SDFGFSCHLEPGEKLRELCGTPGYLAPEILKCSMD-ETHPGYGKEVDLWACGVILFTLLA PHKg1_Hsap TDFGFSCQLEPGERLREVCGTPSYLAPEIIECSMN-EDHPGYGKEVDMWSTGVIMYTLLA PHKg2_Mmus SDFGFSCHLEAGEKLRELCGTPGYLAPEILKCSMD-ETHPGYGKEVDLWACGVILFTLLA PHKg1_Mmus TDFGFSCQLQPGEKLREVCGTPSYLAPEIIQCSMD-DGHPGYGKEVDMWSTGVIMYTLLA Y50D7A.3_Cele SDFGFATRIPRGKKLRDLCGTPGYLAPETIRCQWY-DNAEGYSLEVDEWALGVIMYTLLA PHKG1_Spur SDFGMAAELTEGVYLRELCGTPGYMAPEMLKCSMGLENISSYGQKIDLWACGVIMYTLLV PhK__Dmel TDFGFAKQLQEGEKLTNLCGTPGYLAPETLKCNMF-EGSPGYSQEVDIWACGVIMFTLLV AqueK079_Aque SDFGFATRVEENDELSDLLGTPGYLAPELLKRSTE-PDAPGYNKEVDLWACGVIMYTLLA :***:: .: . * :: ***.*:*** :. . .*. ::* *: ***::***. PHKg2_Hsap GSPPFWHRRQILMLRMIMEGQYQFSSPEWDDRSSTVKDLISRLLQVDPEARLTAEQALQH PHKg1_Hsap GSPPFWHRKQMLMLRMIMSGNYQFGSPEWDDYSDTVKDLVSRFLVVQPQNRYTAEEALAH PHKg2_Mmus GSPPFWHRRQILMLRMIMEGQYQFTSPEWDDRSNTVKDLISKLLQVDPEARLTAEQALQH PHKg1_Mmus GSPPFWHRKQMLMLRMIMDGKYQFGSPEWDDYSDTVKDLVSRFLVVQPQDRCSAEEALAH Y50D7A.3_Cele GCAPFYHRKQLMMLRLIQQGKFEFRNEQWANITAEAKNLITQLLQVDATKRISSKECLAH PHKG1_Spur GRPPFWHRKKMLMLRAIMEGRYRFGSPEWDDISDTPKDLISKLLVVDPKLRLTAEEALEH PhK__Dmel GCPPFWHRKQMVMLRNIMEGKYSFTSPEWADISEDPKDLIRKCLVVDPSQRITVKEVLRH AqueK079_Aque GFPPFWHRKQLIMLRKIMNGDYEFVSPEWDEISDAAKDMIRRLLTVDPKQRMTALEALEH * .**:**::::*** * .* : * . :* : : *::: : * *:. * : : * * PHKg2_Hsap PFFERCEG---------------------------------------------------- PHKg1_Hsap PFFQQYLV---------------------------------------------------- PHKg2_Mmus PFFERCEG---------------------------------------------------- PHKg1_Mmus PFFQEYVV---------------------------------------------------- Y50D7A.3_Cele EWMIPIAQQQAPQ----------------------------------------------- PHKG1_Spur PFFQQTEV---------------------------------------------------- PhK__Dmel PFFNQMVLM---GDRRHPAPPIAPAQTNSRHLLQPEASSYRFGQLNSSCAGAPNYLYCAP AqueK079_Aque PFLESKPA---------------------------------------------------- :: PHKg2_Hsap ------------------------------------------------------------ PHKg1_Hsap ------------------------------------------------------------ PHKg2_Mmus ------------------------------------------------------------ PHKg1_Mmus ------------------------------------------------------------ Y50D7A.3_Cele ------------------------------------------------------------ PHKG1_Spur ------------------------------------------------------------ PhK__Dmel QSSYSSNRMRDGALDDAGASAASATCHVMSPSNASNSYATNTTANTSNSALASASSHKTL AqueK079_Aque ------------------------------------------------------------ PHKg2_Hsap ------------------------------------------------------------ PHKg1_Hsap ------------------------------------------------------------ PHKg2_Mmus ------------------------------------------------------------ PHKg1_Mmus ------------------------------------------------------------ Y50D7A.3_Cele ----------------------------MVPVV------------------------EVE PHKG1_Spur ------------------------------------------------------------ PhK__Dmel TAMVYYQQQPQQHQTQQQQQQYQQQQTTQLPVQLQLQHPLLQTGGDGKQSVYAPPTVQ-- AqueK079_Aque ------------------------------------------------------------ PHKg2_Hsap --SQPWNLTPRQRFRVAVWTVLAAGRVALSTHRVRPLTKNALLRDPYALRSVRHLIDNCA PHKg1_Hsap --EEVRHFSPRGKFKVIALTVLASVRIYYQYRRVKPVTREIVIRDPYALRPLRRLIDAYA PHKg2_Mmus --SQPWNLTPRQRFRVAVWTILAAGRVALSSHRLRPLTKNALLRDPYALRPVRRLIDNCA PHKg1_Mmus --EEVRHFSPRGKFKVICLTVLASVKIYYQYRRVKPVTREIVIRDPYALRPLRRLIDAYA Y50D7A.3_Cele LVKDQTSERARKRFKTAIIWVRFFQRLAKYKYLKTVIDRDVLRKRPFRDRDIRHEAESSM PHKG1_Spur --PIGTTFNARRKFKAACLVVYGVVRLRH-YCGQRIISPHSIQENPYGVKAIRKALDGCA PhK__Dmel -LRKQSRFNARKKFQFAILVIRAIIRIRRLRFTAEPLHVEEAIRDPYRVKVLRKVIDGCA AqueK079_Aque --E-FVIFSAGRKLKAILWCVRFCVAVDRSRKTPKVVTIKDIGTSPYENRYIRKLIDTCA . ::: : : : . *: : :*: : PHKg2_Hsap FRLYGHWVKKGEQQNRAALFQHRPPGPFPIMGPEEE---GDS--A--------------- PHKg1_Hsap FRIYGHWVKKGQQQNRAALFENTPKAVLLSLAE-E------------------------- PHKg2_Mmus FRLYGHWVKKGEQQNRAALFQHQPPRLFPIAATELE---GDS--G--------------- PHKg1_Mmus FRIYGHWVKKGQQQNRAALFENTPKAVLLSLAEEE------------------------- Y50D7A.3_Cele FSVYGHWVNRGFYYSRDMLFANKPRPKIAKKTDGAAAVEQKLKVPPIALRKFNFLAEIFQ PHKG1_Spur FNIYRHWVKKGQGQDRAALFANSPKMDIKNLNNSLSSSQQTTP-T--------------- PhK__Dmel FRVYGHWVKKGEGQNRAALFENTPRTELHALY---------------------------- AqueK079_Aque FHIYSPWVKRGEEQNRAALFETAPKVAMKHPNFYISS----------------------- * :* **::* .* ** * : PHKg2_Hsap --------------------AITED-----------------EAVLVLG PHKg1_Hsap -----------------------------------------------DY PHKg2_Mmus --------------------AITED-----------------EATLVRS PHKg1_Mmus -----------------------------------------------DF Y50D7A.3_Cele KKKLDYFDWKMFKIPDFNSNSVKNSRFSLRFYVKNIEFPLFPIIFLPPP PHKG1_Spur --------------------MSRSS-----------------STTGMAT PhK__Dmel -------------------------------------------INNLSR AqueK079_Aque ------------------------A-----------------AVTFTFT