CLUSTAL W (1.83) multiple sequence alignment TRRAP_Hsap_TRRAP MAFVATQGA-TV-VDQ-T-TL-M---KK-------------------------------- SMG1_Hsap_SMG1 MSRRAPGSR-LSSG--GG-GG-G---TK-----------YP-RSWNDWQPR-TDSASADP FRAP_Hsap_FRAP MLGTGPAAA-TTAA--TT--------SS-------------------------------- mei-41_Dmel_ATR MYAKSLL---EV-LQH-A------------------------------------------ CG2905_Dmel_TRRAP MSVIENVPV-N----------------T-------------------------------- CG6535_Dmel_ATM MSALLNEIQ-RI------------------------------------------------ CG4549_Dmel_SMG1 MKNAIHPEN-CNG---AG-TE-----EE-----------AS----SAFH--------AEI FRAP_Mmus_FRAP MLGTGPAVA-TASA--AT--------SS-------------------------------- DNAPK_Mmus_DNAPK MAEEGTGVR-CW-LLQ-LQEF-L---SAADRCS-AAGAS--------------------- ATR_Mmus_ATR MGDHGLELA-SM-IPA-L------------------------------------------ ATM_Mmus_ATM MSLALNDLL-IC------------------------------------------------ C47D12.1_Cele_TRRAP MDPAMASPG-YRSVQSDR--------SN-------------------------------- B0261.2_Cele_FRAP MLQQHGISF-QMNA--D-RQN-KAA--T-------------------------------- atm-1_Cele_ATM MKHYKKIIH--------------------------------------------------- atl-1_Cele_ATR MNIDKDVSA-LL-CTA-K-KY-V---TQ-------------------------------- TEL1_Scer_ATM MEDHGIV---ET-LN--------------------------------------------- MEC1_Scer_ATR MESHVKYLD-EL------------------------------------------------ ATM_Hsap_ATM MSLVLNDLL-IC------------------------------------------------ ATR_Hsap_ATR MGEHGLELA-SM-IPA-L------------------------------------------ DNAPK_Hsap_DNAPK MAGSGAGVR-CS-LLR-LQET-L---SAADRCG-AALAG--------------------- TOR_Dmel_FRAP MSTTSVV----------------------------------------------------- SMG1_Mmus_SMG1 MSRRAPGSR-LSSG--GG----G---TK-----------YP-RSWNDWQPR-TDSASADP TRRAP_Mmus_TRRAP MAFVATQGA-TV-VDQ-T-TL-M---KK-------------------------------- smg-1_Cele_SMG1 MITSRNNDI-G------------------------------------------------- TOR1_Scer_FRAP MEPHEEQIW-KS-KLLKAANN-DMDMDR-------------------------------- TOR2_Scer_FRAP MNKYINKYT-TPPNLLSLRQR-AEGKHR-------------------------------- TRA1_Scer_TRRAP MSLTEQIE---------------------------------------------------- ATR_Ddis_ATR MPSEQFQ---EQ-QRQQQ------------------------------------------ DNAPK_Ddis_DNAPK MDNIYQRIE-NY-LIK-LFQT-I---SETNNNNNNNNTNN-------------------- SMG1_Ddis_SMG1 MNDSNSSND-SCNT--EN-NT-L---TA-----------TK-NSINNTTTT-TTTPNNNV Tor_Ddis_FRAP MSQHEQPSI--------------------------------------------------- TRRAP_Ddis_TRRAP MSTNPPQPP-PSST--IAS--------N-----------P-------PQPIATPMSTTNP ATMa_Spur_ATM KQIDIVKKE-L------------------------------------------------- ATR_Spur_ATR SSYQMRQR---------------------------------------------------- DNAPK_Spur_DNAPK MIVCALLEYRSD-DVW-LEDDVV---NREIRKR--------------------------- FRAP_Spur_FRAP MSQMNS------------------------------------------------------ SMG1_Spur_SMG1 LT---------------------------------------------------------- TRRAP_Spur_TRRAP DETRLK------------------------------------------------------ CC1G_00839_Ccin_ATM MASTLKSIL--DALKDG------------------------------------------- CC1G_08126_Ccin_ATR MSTNASKAT-TE-LDG-AANA-N----------SSNFKN--------------------- CC1G_00894_Ccin_FRAP MASADQAPV-GDQ----------------------------------------------- CC1G_06302_Ccin_PI3K MDKDNRDDF-TFAR--L------------------------------------------- CC1G_04234_Ccin_PI4K MQAALNDLS-V------------------------------------------------- CC1G_13883_Ccin_PI4K MDCLEFNI---------------------------------------------------- CC1G_00331_Ccin_TRRAP MSQVQRAMV-SPSIQG-TI----------------------------------------- AqueK043_Aque_ATM MAPYVLLNL-Y------------------------------------------------- AqueK044_Aque_ATR MLMVGKL------LE--------------------------------------------- AqueK045_Aque_DNAPK MSSSGYKFG-HN-NSE-GKE---------------------------------------- AqueK046_Aque_FRAP TN---------------------------------------------------------- AqueK047_Aque_SMG1 MLYTTIMPV-FFTR--V------------------------------------DMIENSP AqueK048_Aque_TRRAP MNFMEA------------------------------------------------------ ATM_Smoe_ATM MYMVFQIEE-AK------------------------------------------------ ATR_Smoe_ATR MIFCRGM---DE-DN--------------------------------------------- DNAPK_Smoe_DNAPK MLVESDTSA-QL-GRT-KLDL-L---I--------------------------------- FRAP_Smoe_FRAP MAGAQGVAP-RPP---D------------------------------------------- SMG1_Smoe_SMG1 MAEMLLQTL-ASQV--RAAHT-F---DD-----------HGGGGGAAVTAA----ALPPP GK008_Glam_FRAP MSTDAITSS-R------------------------------------------------- GK009_Glam_PIKK-Unclassified MLASSLRSL-MANY--HATGGVV---QD-------------------------------- TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 DNLKYS--SSRDRGGSSSY----------------------------------------- FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ---------------------------YQ------------------------------- ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP -----------------TSN--------RIVS---APATNE-FD---------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ---------------------------HQ------------------------------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 DTLKYS--SSRDRGVSSSY----------------------------------------- TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP -------------------N--------VP----LAPNLNVNMNMKMNASRNGDEF--GL TOR2_Scer_FRAP -----------------TRK--------KLTHKSH------SHDDEMSTTSNTDSNHNGP TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK -------------------NVGIKFENDLL------------------------------ SMG1_Ddis_SMG1 NCLKTS--GSIK------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP SQPTITSSSAASSSSSSSSG---------------------------------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ---------------------------SG------------------------------- CC1G_00894_Ccin_FRAP ----------------------------Q------------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 SELS-------------------------------------------------------- AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ----------------------------A------------------------------- SMG1_Smoe_SMG1 PLLP------------S------------------------------------------- GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP --------------------------------YL-----------------QFV------ SMG1_Hsap_SMG1 -------------------------------GLQ-----------------PSN------ FRAP_Hsap_FRAP ----------------------------NVSVLQ-----------------QFA------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP --------------------------------FR-----------------NYL------ CG6535_Dmel_ATM -----------------------------------------------------L------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ----------------------------NVSVLQ-----------------QFA------ DNAPK_Mmus_DNAPK ----------------------------LIR------------SL--------G----QE ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM -----------------------------------------------------C------ C47D12.1_Cele_TRRAP ----------------------------HLTELE-----------------TRI------ B0261.2_Cele_FRAP ----------------------ERHRKQGIDAAR-----------------ALA------ atm-1_Cele_ATM ---------------------------------------------------QVL------ atl-1_Cele_ATR ------------------------------KEFNRQKMKFLLDDITKLLSKSFV------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR -----------------------------------------------------I------ ATM_Hsap_ATM -----------------------------------------------------C------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ----------------------------LIR------------GL--------G----QE TOR_Dmel_FRAP ---------------------------------Q-----------------QFV------ SMG1_Mmus_SMG1 -------------------------------GLQ-----------------PSN------ TRRAP_Mmus_TRRAP --------------------------------YL-----------------QFV------ smg-1_Cele_SMG1 ---------------------------------------------------NLI------ TOR1_Scer_FRAP TSSRFDGVVIGS---NGDVN--------FKPILE-----------------KIF------ TOR2_Scer_FRAP --NDSGRVITGSAGHIGKISFVDSELDTTFSTLN-----------------LIF------ TRA1_Scer_TRRAP ---------------------------------------------------QFA------ ATR_Ddis_ATR ------------------------------Q------------QY--------Q------ DNAPK_Ddis_DNAPK ----------------------------LVN------------EL--------GSIILKE SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ----------------------------WADALT-----------------KLL------ TRRAP_Ddis_TRRAP ----------------------------NPVNFE-----------------SYA------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ----------------------------------------------------LV------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ----------------------------LFK------------SL--------N------ CC1G_00894_Ccin_FRAP --------------------------------LN-----------------AIF------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K --------------------------------HQ-----------------RIL------ CC1G_00331_Ccin_TRRAP -----------------------------------------------------A------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM -----------------------------------------------------V------ ATR_Smoe_ATR ------------------------------E------------QV--------Q------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP --------------------------------LQ-----------------RLL------ SMG1_Smoe_SMG1 ---------------------------------V-----------------QVC------ GK008_Glam_FRAP --------------------------------FY-----------------PYL------ GK009_Glam_PIKK-Unclassified ------------------------------AELL-----------------ALS------ TRRAP_Hsap_TRRAP --------------AA---LTD--------V--N------TP-D-E------------TK SMG1_Hsap_SMG1 --------------SAV-VSRQ--------R--H------D----D------------TR FRAP_Hsap_FRAP --------------SG---LKS--------R--N------E----E------------TR mei-41_Dmel_ATR --------------------HH--------I--G------YA-THG------------D- CG2905_Dmel_TRRAP --------------NI---LND--------S--S------SK-D-E------------LK CG6535_Dmel_ATM --------------GD---LQS--------G--K------A----A------------SR CG4549_Dmel_SMG1 -------------------DRV--------L--L------N----N------------NG FRAP_Mmus_FRAP --------------SG---LKS--------R--N------E----E------------TR DNAPK_Mmus_DNAPK CVLSTSSAVQALQISL---VFSRDFGLLVFI--RK--SLSI------------------- ATR_Mmus_ATR --------------------RE--------L--A------SA-T-P------------E- ATM_Mmus_ATM --------------RQ---LEH--------D--R------A----T------------ER C47D12.1_Cele_TRRAP --------------QN---LAD--------NSQR------D----D------------VK B0261.2_Cele_FRAP --------------SQ---YRS--------R--I------TENRDA------------NQ atm-1_Cele_ATM --------------LK---LHS--------VCI--------------------------- atl-1_Cele_ATR --------------SR---IEQ--------L--D------ENEF-M------------EK TEL1_Scer_ATM ---------------------F--------L--S------ST-K-I------------K- MEC1_Scer_ATR --------------LA---IKD--------L--N------SG-V-D------------SK ATM_Hsap_ATM --------------RQ---LEH--------D--R------A----T------------ER ATR_Hsap_ATR --------------------RE--------L--G------SA-T-P------------E- DNAPK_Hsap_DNAPK CVLSSSPAVLALQTSL---VFSRDFGLLVFV--RK--SLNS------------------- TOR_Dmel_FRAP --------------NG---LKS--------R--N------R----N------------VQ SMG1_Mmus_SMG1 --------------SAV-VSRQ--------R--H------D----D------------TR TRRAP_Mmus_TRRAP --------------AA---LTD--------V--N------TP-D-E------------TK smg-1_Cele_SMG1 --------------EQ---FRQ--------R----------------------------- TOR1_Scer_FRAP --------------RE---LTS--------D--Y------K----E------------ER TOR2_Scer_FRAP --------------DK---LKS--------D--V------P----Q------------ER TRA1_Scer_TRRAP --------------SR---FRD--------D--D------AT-L-Q------------SR ATR_Ddis_ATR --------------------QQ--------L--E------RE-R-Q------------E- DNAPK_Ddis_DNAPK LVLE---EEIGLVASL---LFTGDHSLLKYL--EKSSTISN------------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP --------------ND---LKS--------K--K------E----E------------DR TRRAP_Ddis_TRRAP --------------RRCFELNN--------N--N------E----Q------------TQ ATMa_Spur_ATM --------------NK--------------K--T------V------------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK -------YGMAIYSAV---LTQWE-------------TL--------------------- FRAP_Spur_FRAP --------------GG---LKS--------R--H------D----D------------VR SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ---------------------------------T------A----T------------AR CC1G_08126_Ccin_ATR --------------QV---LED--------L--K---RRPEG-F-D------------PA CC1G_00894_Ccin_FRAP --------------SG---LKS--------R--S------A----D------------TR CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K --------------SE---LAS--------K--Q------D----D------------TP CC1G_00331_Ccin_TRRAP --------------PA---FEM--------L--A---QESSAQH-K------------AR AqueK043_Aque_ATM --------------SE----GS--------L--C------P----D------------I- AqueK044_Aque_ATR ---------------------E--------T--D------HD-S---------------- AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM --------------L--------------------------------------------- ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP --------------SE---LRF--------K--T------A----S------------IK SMG1_Smoe_SMG1 --------------TLL-K---------------------M----N------------LQ GK008_Glam_FRAP --------------AD---LKS--------I--D------P----N------------IY GK009_Glam_PIKK-Unclassified --------------DG---LLE--------D--A------RR-S-PVSCAFAASLAIRTA TRRAP_Hsap_TRRAP LK-MM--Q---------------------------------------EVSENF----ENV SMG1_Hsap_SMG1 V-HAD--IQNDEKGGYSVNGGSGE-------------------------------N---- FRAP_Hsap_FRAP AK-AA--K---------------------------------------ELQ-----HYV-- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP LK-AT--Q---------------------------------------ELSEHF----EMI CG6535_Dmel_ATM NK-GI--Q---------------------------------------QLD-----EKL-- CG4549_Dmel_SMG1 N-HGD--SSNEGGGGNGSGRGGATGSGNIAGLGGSESMWSPGGGKSHDVA-----Q---- FRAP_Mmus_FRAP AK-AA--K---------------------------------------ELQ-----HYV-- DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM RK-EV--D---------------------------------------KFK-----RLI-- C47D12.1_Cele_TRRAP LK-ML--Q---------------------------------------EIWSTI----ENH B0261.2_Cele_FRAP RQ-AA--R---------------------------------------ELS-----RYV-- atm-1_Cele_ATM -G-QL--S---------------------------------------KLEEYR----ETR atl-1_Cele_ATR IM-ILQSI---------------------------------------TFTLHLITEKQEL TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR VQ---------------------------------------------------------- ATM_Hsap_ATM KK-EV--E---------------------------------------KFK-----RLI-- ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP NK-AT--Q---------------------------------------DLL-----FYV-- SMG1_Mmus_SMG1 G-HAD--IQNDEKGGYSVNGGSGE-------------------------------N---- TRRAP_Mmus_TRRAP LK-MM--Q---------------------------------------EVSENF----ENV smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP KL-AS--I---------------------------------------SLF-----DLL-- TOR2_Scer_FRAP AS-GA--N---------------------------------------ELS-----TTL-- TRA1_Scer_TRRAP YS-TL--S---------------------------------------ELYDIM----ELL ATR_Ddis_ATR KE-QN------------------------------------------------------- DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 L-SAS--SVPFI---------PGS-------------------------------S---- Tor_Ddis_FRAP VK-AS--K---------------------------------------NLK-----SYV-- TRRAP_Ddis_TRRAP LLALV--T---------------------------------------EIR-----DNIEL ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP TR-AA--K---------------------------------------NLQ-----HYV-- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ---AA--Q---------------------------------------EISENF----EVI CC1G_00839_Ccin_ATM KE-AL--Q---------------------------------------EFRTAV----FAD CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP MQ-AA--E---------------------------------------DLK-----RFV-- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K GQDSS--K---------------------------------------DLI----ISKV-- CC1G_00331_Ccin_TRRAP TD-FEAMG---------------------------------------GIWAGMAPTIKNP AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 --SL-------------------------------------------------------- AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP DGAAA--A---------------------------------------ALR-----KHV-- SMG1_Smoe_SMG1 M-LA-------------------------------------------------------- GK008_Glam_FRAP TRAA---M---------------------------------------AIR-----MQV-- GK009_Glam_PIKK-Unclassified GE-GP--E---------------------------------------RLE-----RIV-- TRRAP_Hsap_TRRAP T-------SSP-----QYSTFLEHIIPRFLT------------------FLQDGEVQFLQ SMG1_Hsap_SMG1 -------------------TYGRKSLGQELR------------------VNNVTSPEFT- FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ----------------IF------------------------------------------ CG2905_Dmel_TRRAP M-------QSP-----AYPSFLDNSLKIFMR------------------ILQDGEPQFIQ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 -------------------AFANALL---LRN-----------------MNHVVGKGQP- FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ----------E-----DF------------------------------------------ ATR_Mmus_ATR ----------------EY------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP F-------TLSSH-----EKVVERLILSFLQ------------------VFCNTSPQFIA B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM T-------YRMKQ----------------------------------------------- atl-1_Cele_ATR --------SSE-----EKIRLFQ------------------------------------- TEL1_Scer_ATM ----------------ER------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ----------------EY------------------------------------------ DNAPK_Hsap_DNAPK ----------I-----EF------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 -------------------TYGRKSLGQELR------------------INNVTSPEFT- TRRAP_Mmus_TRRAP T-------SSP-----QYSTFLEHIIPRFLT------------------FLQDGEVQFLQ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP N-------SPE-----DYHFFLQAVIPLLLN------------------QLKEVPISYDA ATR_Ddis_ATR ----------------EK------------------------------------------ DNAPK_Ddis_DNAPK ----------K-----EN------------------------------------------ SMG1_Ddis_SMG1 -------------------AS--------------------------------------- Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP V-------HTV-----EYPTFLNFLFPVFYN------------------ILRQGAVQFN- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP I-------SSS-----QYHSFLETAIPHFLK------------------VLKDEKPQFIA CC1G_00839_Ccin_ATM RDLLPYLTRQKSNDKHAYKDWLSI-VQALLASVQADKPLLRQKIAQGRTVPATVTSRF-- CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP T-------IYN-----DL------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP -------------------------HSS-LL------------------LLKE------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP EKPAQQLR-----------------------KLVLEIIHRI------------------- SMG1_Hsap_SMG1 --------------------------------------------------S--VQH---- FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR SGSLHQ----------------------------------A------------------- CG2905_Dmel_TRRAP ENTMQHIR-----------------------KLILEMIHRL------------------- CG6535_Dmel_ATM ----SSCR--EDLDKLFLSKTS-DISWTTIFEASKEAL---------------------- CG4549_Dmel_SMG1 --------------------------------------------------V--VQN---- FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK RDCREEAL-----------------------KFLCVFLEKI------------------- ATR_Mmus_ATR NTVVQKPR-----------------------QILCQFIDRI------------------- ATM_Mmus_ATM ----QDPETVQHLDRHSDSKQGKYLNWDAVFRFLQKYI---------------------- C47D12.1_Cele_TRRAP ENNTQQLR-----------------------KLMLEIILRL------------------- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM QAVTAFEQ-----------------------QIQN------------------------- atl-1_Cele_ATR --------------------------------SVIASM--C------------------- TEL1_Scer_ATM NNALDELT-----------------------TILKEDPERI------------------- MEC1_Scer_ATR -------------------------------------IKKV------------------- ATM_Hsap_ATM ----RDPETIKHLDRHSDSKQGKYLNWDAVFRFLQKYI---------------------- ATR_Hsap_ATR NTVVQKPR-----------------------QILCQFIDRI------------------- DNAPK_Hsap_DNAPK RECREEIL-----------------------KFLCIFLEKM------------------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 --------------------------------------------------S--VQH---- TRRAP_Mmus_TRRAP EKPAQQLR-----------------------KLVLEILHRI------------------- smg-1_Cele_SMG1 ---------------------------------------------------DTPQK---- TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP HSPEQKLR-----------------------NSMLDIFNRC------------------- ATR_Ddis_ATR ESLISNLV-----------------------SLIIE----IQQLGGNEYNS--QNHPINL DNAPK_Ddis_DNAPK VKIKVSIL-----------------------NLIAEFIEIL------------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP --------------------------------------------------DGPEQK---- ATMa_Spur_ATM ---------QLQLDKHTLEGKSN-FTWQEVFKCVWAYI---------------------- ATR_Spur_ATR --------------------------------RCAEIFSR-------------------- DNAPK_Spur_DNAPK --------------------------------------SNL------------------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ESPLQHLR-----------------------KLLLELLHRM------------------- CC1G_00839_Ccin_ATM ------TT-----------------------A---VGTVRW------------------- CC1G_08126_Ccin_ATR -DASHRVL-----------------------EVAQSFLCGY------------------- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP IQAQIKML-----------------------SYLAFVMRYL------------------- AqueK043_Aque_ATM ---------RCSLA-----------------DALVAAV---------------------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR EALCSTIG-----------------------KLFCV------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP -----P-TNE-------------------------------------------------- SMG1_Hsap_SMG1 -----------------------GSRALA--T-KDMRKSQERSM---------------- FRAP_Hsap_FRAP -------------------------------T-MEL-----REM---------------- mei-41_Dmel_ATR --------------------LLI------------------LKE---------------- CG2905_Dmel_TRRAP -----P-ITE-------------------------------------------------- CG6535_Dmel_ATM -------------------------------F-KQA-----GNLEDVNEKVFKTLAGKNY CG4549_Dmel_SMG1 -----------------------HRKAYQCKG-DT-----INPM---------------- FRAP_Mmus_FRAP -------------------------------T-MEL-----REM---------------- DNAPK_Mmus_DNAPK -----D-QKVM------HYSLDI------------------KN----------------- ATR_Mmus_ATR -----L-TDVN------VVALEL------------------VKK---------------- ATM_Mmus_ATM -------------------------------Q-KEM-----ESLRTAKSNVSATTQ---S C47D12.1_Cele_TRRAP -----S-NVE-------------------------------------------------- B0261.2_Cele_FRAP -------------------------------R-SEL-----KDE---------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -----AFEDE-------------------------------------------------- TEL1_Scer_ATM -----P-TKAL-----STTAEAL------------------VEL---------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM -------------------------------Q-KET-----ECLRIAKPNVSASTQ---A ATR_Hsap_ATR -----L-TDVN------VVAVEL------------------VKK---------------- DNAPK_Hsap_DNAPK -----G-QKIA------PYSVEI------------------KN----------------- TOR_Dmel_FRAP -------------------------------K-TEL-----REM---------------- SMG1_Mmus_SMG1 -----------------------GSRALA--T-KDMRKSQERSM---------------- TRRAP_Mmus_TRRAP -----P-TNE-------------------------------------------------- smg-1_Cele_SMG1 -----------------------ERKAI---L-AR-----IEEI---------------- TOR1_Scer_FRAP -------------------------------V-SLE-----HEL---------------- TOR2_Scer_FRAP -------------------------------T-SLA-----REV---------------- TRA1_Scer_TRRAP -----L-MNQ-------------------------------------------------- ATR_Ddis_ATR SKDSIV-DDKNNKKDLDTTSVTNNNKQQQ------------QQN---------------- DNAPK_Ddis_DNAPK -----Q-VRTD------DYAIAI------------------KN----------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP -------------------------------I-SQS-----REM---------------- TRRAP_Ddis_TRRAP -----------------------IRNTI---L-DI-----LNKL---------------- ATMa_Spur_ATM -------------------------------V-KEI-----ELLKGKGASSS-RTS---T ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK -----G-Q---------------------------------------------------- FRAP_Spur_FRAP -------------------------------S-TEL-----REV---------------- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -----P-TNE-------------------------------------------------- CC1G_00839_Ccin_ATM -----I-VEE-------------------------------------------------- CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP -------------------------------Q-VSY-----AEM---------------- CC1G_06302_Ccin_PI3K ---------------------------------SDLKLPVTFRI---------------- CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K -------------------------------QTRDV-----SEV---------------- CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM -------------------------------S-TD------------------------- AqueK044_Aque_ATR -------QTIL-----KHYK----------------------EV---------------- AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------AAANL------------------VPT---------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -------------------------------Q-EEA-----RDL---------------- SMG1_Smoe_SMG1 -------------------------------A-QGLALHPSAAL---------------- GK008_Glam_FRAP -------------------------------E-KDS-----RQM---------------- GK009_Glam_PIKK-Unclassified -------------------------------L-LSD-----LQL---------------- TRRAP_Hsap_TRRAP --------------------------------------------HLRPHTK-NVLS---- SMG1_Hsap_SMG1 -----------------------S-------------YSD----ES-------RLS---- FRAP_Hsap_FRAP -----------------------S-------------QEE----S-TRFYD-QLNH---- mei-41_Dmel_ATR -----------------------CD------------MDT----K--------------- CG2905_Dmel_TRRAP --------------------------------------------SLRQHVK-TIIT---- CG6535_Dmel_ATM LYDNVLEKITQFN---LEAGSQTS--------------GN----GHFLAKT-SIFS---- CG4549_Dmel_SMG1 -----------------------A-------------NGE----DL-------RLS---- FRAP_Mmus_FRAP -----------------------S-------------QEE----S-TRFYD-QLNH---- DNAPK_Mmus_DNAPK -----------------------TCT-----------SVY----T--------------- ATR_Mmus_ATR -----------------------TDA-----------QPT----S--------------- ATM_Mmus_ATM SRQKKMQEISSLVRYFIKCA---N--------------KR----APRLKCQ-DLLN---- C47D12.1_Cele_TRRAP --------------------------------------------AMKHHSK-EIIK---- B0261.2_Cele_FRAP -----------------------P-------------NTF----S-DAFLN-AIDGRTDI atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR --------------------------------------------ELAKCFD-RILS---- TEL1_Scer_ATM -----------------------LAS-----------EHT-------------------- MEC1_Scer_ATR ------------------------PT-----------DPS----S--------------- ATM_Hsap_ATM SRQKKMQEISSLVKYFIKCA---N--------------RR----APRLKCQ-ELLN---- ATR_Hsap_ATR -----------------------TDS-----------QPT----S--------------- DNAPK_Hsap_DNAPK -----------------------TCT-----------SVY----T--------------- TOR_Dmel_FRAP -----------------------S-------------QEE----L-AQFFD-EFDH---- SMG1_Mmus_SMG1 -----------------------S-------------YSD----ES-------RLS---- TRRAP_Mmus_TRRAP --------------------------------------------HLRPHTK-NVLS---- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP -----------------------S-------------IEE----F-QAVSN-DINN---- TOR2_Scer_FRAP -----------------------S-------------AEQ----F-QRFSN-SLNN---- TRA1_Scer_TRRAP --------------------------------------------TFQPYAM-EVLE---- ATR_Ddis_ATR -----------------------KTT-----------HKI----Q--------------- DNAPK_Ddis_DNAPK -----------------------TCV-----------LVF----R--------------- SMG1_Ddis_SMG1 ---------------------------------------L----PS-------ILS---- Tor_Ddis_FRAP -----------------------T-------------NEN----F-TKFMN-ELNNN--- TRRAP_Ddis_TRRAP -----------------------P-------------NNE----LLRPHIL-VLLQ---- ATMa_Spur_ATM TNQTRKREVRSTLKWIVGVA---N--------------GR----GPKLSVV-KLVK---- ATR_Spur_ATR -----------------------AKA---------------------------------- DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP -----------------------S-------------ADE----R-TSFMD-ELNH---- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP --------------------------------------------QLRTFVR-QILE---- CC1G_00839_Ccin_ATM --------------------------------------------YYEYFSK-SVLD---- CC1G_08126_Ccin_ATR ------------------------A------------SPH----T--------------- CC1G_00894_Ccin_FRAP -----------------------T-------------SDA----A-AKLWDDHINR---- CC1G_06302_Ccin_PI3K -----------------------S-------------QLE----GI-------R------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K -----------------------S-------------AEGCPEPT-TRVY---------- CC1G_00331_Ccin_TRRAP -------------------------N-----------ETE----A--------------- AqueK043_Aque_ATM --------LKGNVLFLTRKR---K------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM -WAQGQREL----------------------------------------AV-SLVK---- ATR_Smoe_ATR -----------------------SDM-----------QQL----S--------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -----------------------S-------------AEG----L-TKFLD-ILYD---- SMG1_Smoe_SMG1 -----------------------R-------------LLE-----T-------------- GK008_Glam_FRAP -----------------------L-------------ADP----R-TLFIS-DLMS---- GK009_Glam_PIKK-Unclassified -----------------------GVEQPYVLWILDLQPES----S-ECVLN-WPTTR--- TRRAP_Hsap_TRRAP ----VMFR-FLETENE-----------------------------------ENVLICLRI SMG1_Hsap_SMG1 ----NLLR-RITREDD-------------------------------------RDRRLAT FRAP_Hsap_FRAP ----HIFE-L-------------------------------------------------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ----MMLK-ILKTDNE-----------------------------------ENVLVCLRI CG6535_Dmel_ATM ----AFED-GIKMR-------------------------------------VV------- CG4549_Dmel_SMG1 ----KIIR-RLINENN-------------------------------------PTVSLEL FRAP_Mmus_FRAP ----HIFE-L-------------------------------------------------- DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ----YVMD-TVKDS-------------------------------------SN------- C47D12.1_Cele_TRRAP ----QMMR-LITVENE-----------------------------------ENANLAIKI B0261.2_Cele_FRAP ASQSAIYNCM-------------------------------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ----VLMI-SVTKQDP-----------------------------------RETIYFLQG TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ----YIMD-TVKDS-------------------------------------SN------- ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ----HIFT-M-------------------------------------------------- SMG1_Mmus_SMG1 ----NLLR-RITREDD-------------------------------------RDRRLAT TRRAP_Mmus_TRRAP ----VMFR-FLETENE-----------------------------------ENVLICLRI smg-1_Cele_SMG1 ---------LQTTKNV-----------------------------------ES--LCVKW TOR1_Scer_FRAP ----KILE-L-------------------------------------------------- TOR2_Scer_FRAP ----KIFE-L-------------------------------------------------- TRA1_Scer_TRRAP ----FLLS-VLPKENE-----------------------------------ENGILCMKV ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ----NQYK-LAASNNV-------------------------------------SNNIMMI Tor_Ddis_FRAP ----LIFE-L-------------------------------------------------- TRRAP_Ddis_TRRAP ----LSMY-LLEVDNE-----------------------------------ENALVCLRI ATMa_Spur_ATM ----KMIF-LLKDD-------------------------------------FT------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ----HIFE-L-------------------------------------------------- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ----LMFI-LLEAENE-----------------------------------ENVLVCLKI CC1G_00839_Ccin_ATM ----SLLD-HITSTLLDRRLFDYVSLDYFKTIKSLLLHQPHLDHLDGLRWTNLVEICFNV CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ----RLFA-L-------------------------------------------------- CC1G_06302_Ccin_PI3K -----------------------------------------------------------K CC1G_04234_Ccin_PI4K -----------QRRNT-----------------------------------QSFAVCQRV CC1G_13883_Ccin_PI4K -------M-S-------------------------------------------------- CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ----YLLT-YI------------------------------------------------- ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ----RINC-L-------------------------------------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ----FIRN-L-------------------------------------------------- GK009_Glam_PIKK-Unclassified ----LLLC-L-------------------------------------------------- TRRAP_Hsap_TRRAP II--------ELHKQFRPPITQEIHH--------------------FLDF---------- SMG1_Hsap_SMG1 VK--------QLKEFIQQP----------------------------------------- FRAP_Hsap_FRAP -------------------V---------------------------------------- mei-41_Dmel_ATR -----------------------L-A--------------------SLNY---------- CG2905_Dmel_TRRAP II--------ELHKHFRPSFNSEIQL--------------------FLGF---------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 CS--------KLDQAVRTP----------------------------------------- FRAP_Mmus_FRAP -------------------V---------------------------------------- DNAPK_Mmus_DNAPK -----------------------KDR--------------------TAKC---------- ATR_Mmus_ATR -----------------------V-M--------------------LLDF---------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP VT--------DQGRST------GKMQ--------------------YCGE---------- B0261.2_Cele_FRAP -------------------K---------------------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR LL--------EVVKYC-------------------------------------------- TEL1_Scer_ATM -------------------------K--------------------YCDL---------- MEC1_Scer_ATR -----------------------SQE--------------------YAKS---------- ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR -----------------------V-M--------------------LLDF---------- DNAPK_Hsap_DNAPK -----------------------KDR--------------------AAKC---------- TOR_Dmel_FRAP -------------------V---------------------------------------- SMG1_Mmus_SMG1 VK--------QLKEFIQQP----------------------------------------- TRRAP_Mmus_TRRAP II--------ELHKQFRPPITQEIHH--------------------FLDF---------- smg-1_Cele_SMG1 TY--------LLDNLCWPSL---------------------------------------- TOR1_Scer_FRAP -------------------V---------------------------------------- TOR2_Scer_FRAP -------------------I---------------------------------------- TRA1_Scer_TRRAP LT--------TLFKSFKSILQDKLDS--------------------FIRI---------- ATR_Ddis_ATR -----------------------Q-KY----------------EL-YISR---------- DNAPK_Ddis_DNAPK -----------------------KDQ--------------------SHSV---------- SMG1_Ddis_SMG1 -STPIISSAQQQQQQVPPP----------------------------------------- Tor_Ddis_FRAP -------------------V---------------------------------------- TRRAP_Ddis_TRRAP II--------ELHKNYRNAL---------------------------------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP -------------------V---------------------------------------- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP II--------ELHKYYRPTMQPEVSD--------------------RNQL---------- CC1G_00839_Ccin_ATM IL--------DLDL---------------------------------RTPLTEVDEDSED CC1G_08126_Ccin_ATR -----------------------TRA--------------------WADL---------- CC1G_00894_Ccin_FRAP -------------------I---------------------------------------- CC1G_06302_Ccin_PI3K PK--------SFTEVLENP----------------------------------------- CC1G_04234_Ccin_PI4K LH--------KCHEII-------------------------------------------- CC1G_13883_Ccin_PI4K -------------------A---------------------------------------- CC1G_00331_Ccin_TRRAP -------------------------S--------------------YGE----------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR -----------------------C-NICDNGIASASAVLKDLEYPYWKTV---------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -------------------I---------------------------------------- SMG1_Smoe_SMG1 GS--------PFS----------------------------------------------- GK008_Glam_FRAP -------------------A---------------------------------------- GK009_Glam_PIKK-Unclassified -------------------V---------------------------------------- TRRAP_Hsap_TRRAP --------------------------------VKQIY----KE----------------L SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP -----------------------------------------SSS--DANE-R-------- mei-41_Dmel_ATR --------------------------------CHNVL----RS----------------Q CG2905_Dmel_TRRAP --------------------------------VKEIY----TN----------------L CG6535_Dmel_ATM ------------------------------------------------VK-Y-------- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP -----------------------------------------SSS--DANE-R-------- DNAPK_Mmus_DNAPK --------------------------------KIP------------------------- ATR_Mmus_ATR --------------------------------IQHIM----KS----------------S ATM_Mmus_ATM ------------------------------------------------GL-T-------- C47D12.1_Cele_TRRAP --------------------------------VSQIM----VS----------------F B0261.2_Cele_FRAP -----------------------------------------SNS--NIDQ-K-------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------DVEPSSS----------------L TEL1_Scer_ATM --------------------------------LRNL------------------------ MEC1_Scer_ATR ------------------------------------L----K------------------ ATM_Hsap_ATM ------------------------------------------------GA-I-------- ATR_Hsap_ATR --------------------------------IQHIM----KS----------------S DNAPK_Hsap_DNAPK --------------------------------KIP------------------------- TOR_Dmel_FRAP -----------------------------------------NAT--DINE-K-------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP --------------------------------VKQIY----KE----------------L smg-1_Cele_SMG1 -----------------------------------------TKH--DRND-M-------- TOR1_Scer_FRAP -----------------------------------------HTK--KTST-R-------- TOR2_Scer_FRAP -----------------------------------------HGF--TSSE-K-------- TRA1_Scer_TRRAP --------------------------------IIQIY----KN----------------T ATR_Ddis_ATR --------------------------------IRSI------------------------ DNAPK_Ddis_DNAPK --------------------------------QAA------------------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP -----------------------------------------NSS--VIPE-K-------- TRRAP_Ddis_TRRAP -----------------------------------------ESEIQPFLN-IVLKLYTDL ATMa_Spur_ATM ------------------------------------------------GP-E-------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ----------------------------------EDD----F------------------ FRAP_Spur_FRAP -----------------------------------------SSQ--DVSE-K-------- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP --------------------------------F--------------------------- CC1G_00839_Ccin_ATM EQATPSRKGTPLDSDDDDAPSPGTFAQKRRRNDKDV------------------------ CC1G_08126_Ccin_ATR --------------------------------MEEII----P------------------ CC1G_00894_Ccin_FRAP -----------------------------------------HSQ--NINE-A-------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K --------------------------------------------------------FSDL CC1G_13883_Ccin_PI4K -----------------------------------------SRV--HCN----------- CC1G_00331_Ccin_TRRAP -----------------------------------------T------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR --------------------------------VLKL------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -----------------------------------------ESA--DVSD-N-------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP -----------------------------------------TSS--SYED-R-------- GK009_Glam_PIKK-Unclassified -----------------------------------------CAH--LLDATT-------- TRRAP_Hsap_TRRAP PKV------------------------------------------------VNRYFENPQ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR S----------------------------------------------------------- CG2905_Dmel_TRRAP PNH------------------------------------------------LTSIFETSN CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR PLM------------------------------------------------F-------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP KTMVIDLTA--SGRAGDMFNIKEHKAPPSTSSDEQVITEYLKTCYYQQTVLLN------- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR PQ---------------------------------------------------------- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR PLM------------------------------------------------F-------- DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP PKV------------------------------------------------VNRYFENPQ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP PNL------------------------------------------------INQTFYEAG ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP PST------------------------------------------------IEKTFSSSS ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP PYI------------------------------------------------HKTYFLD-- CC1G_00839_Ccin_ATM ---LPQPTMKRAGRTRRQGQIPVKPAQVECAIILSLLLCSHNNPMSSPSTKID------- CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP VI---------------------------------------------------------- SMG1_Hsap_SMG1 ---------------------------------------------EN------------- FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP DV---------------------------------------------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ---------------------------------------------IN------------- FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ---------------------------------------------EN------------- TRRAP_Mmus_TRRAP GI---------------------------------------------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP KA---------------------------------------------------------- ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ---------------------------------------------QQ------------- Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP SASLSTTTTAISPTTTTTTTPATATTPATTTATGNTITTPPPATPP-------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP VI---------------------------------------------------------- CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ---------------------------------------------DLRFHGVQQ--ATLS CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ---------------------------------------------NLRLHPCQAITSSVA GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------KLV--------------------------------------- FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------MGY--------------------------------------- FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------KLV--------------------------------------- TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------TTTTTTATATAITPT--------------------------- Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP -----------------------STTATAISPTSSTTTTTTATTAAAATIATTTATTTIT ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K DLYVT-----CQ------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------SP---------------------------- CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ATYVYFLQHGCEKVAVESALC--------------------------------------- GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------PENTVPPPEMV---GMI-----TT--IAVKV----N-----PER---- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP -------K----GGI-------------------L--AIASLI----G-----VEG---- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------WVTDLKD---LNLEVLLSE----SYSVRTIH----V-----EKA---- CG6535_Dmel_ATM -------FGDRILSL-------------------L--E-KGIY----SSVSYVRDL---- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP -------K----GGI-------------------L--AIASLI----G-----VEG---- DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ----------------------------------------VNV-----------NGS--Q ATM_Mmus_ATM -------YGADCSNI-------------------L--L-KDIL----SVRKYWCEV---- C47D12.1_Cele_TRRAP -----------------------------------------------------GT----- B0261.2_Cele_FRAP -------R----AGI-------------------Y--LIVCLA----E-----TH----- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM -----------------------------------------TV-----------STTNKL MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM -------YGADCSNI-------------------L--L-KDIL----SVRKYWCEI---- ATR_Hsap_ATR ----------------------------------------VNV-----------SG---- DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP -------K----GGA-------------------L--AMKCLI----N-----CEG---- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------PENTVPPPEMV---GMI-----TT--VAVKV----N-----PER---- smg-1_Cele_SMG1 -------K----TLA-------------------G--KVIRLV----G-----VLL---- TOR1_Scer_FRAP -------V----GAV-------------------L--SIDTLI----S-----FYA---- TOR2_Scer_FRAP -------I----GGI-------------------L--AVDTLI----S-----FYL---- TRA1_Scer_TRRAP ------------EQGDLDSPKEPQADELL-D----EF----SK----N-----DEE---- ATR_Ddis_ATR -----------------------------------------LP-----------ELINSH DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP -------I----GGI-------------------M--AIDELI----D-----VDY---- TRRAP_Ddis_TRRAP PPLPPYMI----KSI-------------------E--SFK-------------------- ATMa_Spur_ATM -------FGADCCSI-------------------I--T-RDVL----GCQKYWHEL---- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP -------K----GGI-------------------L--AIVSLI----G-----IDG---- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------PGTPAPDPMNI---QLFVDKAGFS--CQTII----T-----IQQ---- CC1G_00839_Ccin_ATM -----------------------------------------------------DN----- CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP -------F----GGL-------------------L--GIERLL----E-----LDL---- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------AP----SGP-------------------Y--SIS-------------------- CC1G_13883_Ccin_PI4K ----------------------------------I--AFGELVVNFPA-----IQL---- CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM -------------------------------------------------------K---- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR -----------------------------------------LL-----------TN---- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -------L----GAL-------------------R--AIDVLI----D-----VEL---- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP -------L----ASL-------------------W--VMRELI----Q-----SRP---- GK009_Glam_PIKK-Unclassified -------F----GAA-------------------L--AELCVI----G-----GV----- TRRAP_Hsap_TRRAP ED--S--------------ET----------RTHSIIPRGSLSLKV-LAELPIIVVLMYQ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP -G----N-----------AT--------------------------RI---G-------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP LDSNS--------------QQ----------QIYNLLPRGILSLKV-LQELPIIVVLMYQ CG6535_Dmel_ATM -K----I-----------NE--------------------------YS---R-------- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP -G----N-----------ST--------------------------RI---G-------- DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR G----------------------------------------------------------- ATM_Mmus_ATM -S----Q-----------QQ--------------------------WL---E-------- C47D12.1_Cele_TRRAP -EGKP---------------P----------LKYNMIPSAHQSTKV-LLEVPYLVIFFYQ B0261.2_Cele_FRAP ------------------SG--------------------------NV---I-------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM S----------------------------------------------------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM -S----Q-----------QQ--------------------------WL---E-------- ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP -SL--TA-----------RK--------------------------GI---S-------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ED--S--------------ET----------RTHSIIPRGSLSLKV-LAELPIIVVLMYQ smg-1_Cele_SMG1 -F----D-----------TE-------------------------S----YPE------- TOR1_Scer_FRAP -YT-ERL-----------PN--------------------------ET---S-------- TOR2_Scer_FRAP -ST-EEL-----------PN--------------------------QT---S-------- TRA1_Scer_TRRAP KDFPS--------------KQSSTEPRFENSTSSNGLRSSMFSFKI-LSECPITMVTLYS ATR_Ddis_ATR L----------------------------------------------------------- DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP -D---EN-----------AT--------------------------KI---T-------- TRRAP_Ddis_TRRAP ---------------------------------------------I-LTECPIVVILLFQ ATMa_Spur_ATM -D----Q-----------RT--------------------------WI---E-------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP -D----N-----------AT--------------------------RI---T-------- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP AD--G--------------QK----------VQQTILPKGVNSLKV-LAEYPIIVVLMYQ CC1G_00839_Ccin_ATM -STPE---------------N----------RIARDRGILNRLRQF-LKKYPS------- CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP -EETIES-----------KR--------------------------NH---F-------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ---------------------------------------------N-L------------ CC1G_13883_Ccin_PI4K -GQS--------------IE-------------------------SIM---A-------- CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM -K----E-----------E----------------------------------------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR R----------------------------------------------------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -GES--------------AT--------------------------KT---M-------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP -TIS--------------MI--------------------------PL---T-------- GK009_Glam_PIKK-Unclassified --G--TVRDVLTAPLGTDA----------------------------------------- TRRAP_Hsap_TRRAP LYKLN-------------IHNV-V---A-EF---VP--------------LIMN-TIAIQ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP RFANY-------------LRNL-L---P-SN---DP--------------VVM-EMASKA mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP IYKNA-------------VHQE-V---S-EF---IP--------------LILT-TINLQ CG6535_Dmel_ATM ILSYL-------------FEL--N---V-DM---DE--------------V---L-RTRI CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP RFANY-------------LRNL-L---P-SS---DP--------------VVM-EMASKA DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM LFSLY-------------FRLYLK---P-SQ---DI--------------NRV-L-VARI C47D12.1_Cele_TRRAP HFKTA-------------IQTE-A---L-DF---MR--------------LGLD-FLNVR B0261.2_Cele_FRAP RYANY-------------LLKM-L---N-NGNGLDE--------------DTV-KMASKA atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------LI--TP--------------EIAS-AISLG TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM LFSVY-------------FRLYLK---P-SQ---DV--------------HRV-L-VARI ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP PYLNR-------------LRDL-L---L-IN---DV--------------SVM-EIAARS SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP LYKLN-------------IHNV-V---A-EF---VP--------------LIMN-TIAIQ smg-1_Cele_SMG1 -FLIY-------------LGTL-Y---Q-SV---TKKSEETRADIVFSVYFIVGVISQKT TOR1_Scer_FRAP RLAGY-------------LRGL-I---P-SN---DV--------------EVM-RLAAKT TOR2_Scer_FRAP RLANY-------------LRVL-I---P-SS---DI--------------EVM-RLAANT TRA1_Scer_TRRAP SYKQL-------------TSTS-L---P-EF---TP--------------LIMN-LLNIQ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP RLANY-------------LRIG-L---G-FN---DF--------------TVM-LMASKA TRRAP_Ddis_TRRAP LYNSY-------------MSSN-V---P-KF---IP--------------LIIE---TLS ATMa_Spur_ATM LIETV-------------TMAIHH---T-DQ---GV--------------SLD-P-QARA ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP RFANY-------------LRNL-L---P-SN---DV--------------VVM-EMAAKA SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP LYKQN-------------VHNV-V---A-DF---IP--------------LVMN-TIGLQ CC1G_00839_Ccin_ATM ------------------ESSL-L---H-DF---LS--------------CVEG-TLDAL CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP RFYNY-------------VKHL-L---P-NP---DV--------------HLM-MAASKT CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ----------------------------------SP--------------LL-------- CC1G_13883_Ccin_PI4K ALLDI-------------LRDI-PFIDFD-P----------------------------- CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ----------------------------------------------------D-P-I-S- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ---------------------------G-ST---DS--------------MAL-Y----- ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP KFANC-------------VKRV-L---EEKQ---DP--------------DVL-VRASEV SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP YFEEI-------------ALEL-V---ND-P---SE--------------VII-LTNCVF GK009_Glam_PIKK-Unclassified --APFLSVYACGTALLCMLLGF-G------------------------------------ TRRAP_Hsap_TRRAP VSA----QARQH---------------K--LY--N---KELYADFIA---AQ-------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP IGR----LAMAG---------------D--TF--T----AEYVEFEV---KRAL-EWLGA mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP PTV----TRRN-------------------SP--Q---KEIYVEFMG---AQ-------- CG6535_Dmel_ATM LKCITRTVSLAK---------------D--RVQLH----VDLVEYLPELSSFAL-SAFGA CG4549_Dmel_SMG1 -------------------------------M--T----CS------------------- FRAP_Mmus_FRAP IGR----LAMAG---------------D--TF--T----AEYVEFEV---KRAL-EWLGA DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM IHAVTRGCCSQT---------------D--GL--P----SKFLDLFS----KAI-QYARQ C47D12.1_Cele_TRRAP VPD----EDK-----------------L--KT--N---QIITDDFVS------------- B0261.2_Cele_FRAP LAF----LIATC---------------K--SY--A----AELVDRCL---DHCH-EWLGQ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ASG----FFRYH---------------L--KW--NIIST--------------------- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM IHAVTKGCCSQT---------------D--GL--N----SKFLDFFS----KAI-QCARQ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP LVK----LANMP---------------T--SK--G----ADSFDFDI---KKAF-EVLRG SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP VST----QARQH---------------K--LY--N---KELYADFIA---AQ-------- smg-1_Cele_SMG1 ENR----L-IAT---------------D--TE--NV---EKSLDWII---KV-------- TOR1_Scer_FRAP LGK----LAVPG---------------G--TY--T----SDFVEFEI---KSCL-EWLTA TOR2_Scer_FRAP LGR----LTVPG---------------G--TL--T----SDFVEFEV---RTCI-DWLTL TRA1_Scer_TRRAP IKQ----QQEAREQAESRGEHFTSISTE--II--N---RPAYCDFIL---AQ-------- ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 -------PITTS---------------Q--ST--S----SSMLNLPL---KV-------- Tor_Ddis_FRAP LGR----LARSS---------------G--TL--T----AEFVEFEV---TRAL-EWLSG TRRAP_Ddis_TRRAP LQA----PANST---------------V--TH--H----SQYVDFIA---AQ-------- ATMa_Spur_ATM VQSLVAGATIQG---------------A--LP--T----SYLFNFFG----SML-KRIRT ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP IGH----LALAG---------------G--TF--T----PEYVDFEV---KRAL-EWLGG SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP PTQ----QARAS---------------P--NF--N---KEMYVDFIA---AQ-------- CC1G_00839_Ccin_ATM ALN----RVRDV---------------A--LF--A---RETWDGFVG------------- CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP LGK----IAEIG---------------GGVAF--G----ERFMEYEI---PAAI-ELMQP CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K --------RRHK---------------I-------------------------------- CC1G_13883_Ccin_PI4K ----------------------------------------------------SL-SWHG- CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM --------------------------------------------VRD----ALI-Q---- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP LGH----IVSTG------------------PQ--T----ADIVESQV---SCAL-KWLR- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP IGR----LINAE---------------G-H----G----IDFVPKLF---VISIDKIKSG GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------DRNEG----RRHAAVLVLRELAISVPTFFF------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------RK-----TEIVRVYLIFASELAVNYNHQLN------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------DRNEG----RRHAAVLVLRELAISVPTFFF------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------EKSSPGLSHILAALNIFLKSLAVNFRKRVC------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP NVPHSQQPKNQQEIDQI----RRLAASHLSRELALATPTAFF------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------EKSSSGLNHILAALTIFLKTLAVNFRIRVC------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------ERQEY----RRHSAVFILRELAIALPTYFY------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP STEKN---SFSSSKPDH----AKHAALLIITALAENCPYLLY------------------ TOR2_Scer_FRAP TADNN----SSSSKLEY----RRHAALLIIKALADNSPYLLY------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------DRIEA----RRHAAVLVLKELAQNAPTLFY------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------ERSTTVISCTLSALNIFSLHVAPDRRHHLC------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------DRQEG----RRHAA---------------------------------- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------DKQEA----PRYAGVLILKELARNSPTYFH------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K -----------AVLSEF----VIAWGTHVRSRLGVSGPASLFYDLCSTSTFFVDQVVDSI CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP --------------GES----RRFAAVLILKEMADQAPTVFN------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP DST--------K----------VYTGMLLFNDLT-EVETSF------------------- GK009_Glam_PIKK-Unclassified -------------KGCG----EPFSACLPLLEILRADACAFA------------------ TRRAP_Hsap_TRRAP --------------------------------------IKTL------SFLAYI-IR--I SMG1_Hsap_SMG1 -------LV-KQLDNILAAVH--DV-------------LNESS----------------- FRAP_Hsap_FRAP ----Q--QVQPFFDNIFVAVW--DP-----------------K----------------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP --------------------------------------IKTL------SFLAYI-VR--I CG6535_Dmel_ATM ----V--HMQEILPKLCE-YHDEDAF----------------R----------------- CG4549_Dmel_SMG1 -------FV-WILDNMLT------L-------------YKQCP----------------- FRAP_Mmus_FRAP ----Q--QVQPFFDNIFVAVW--DP-----------------K----------------- DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ----E--AGDEILPTLLY-IWTQHRL----------------N----------------- C47D12.1_Cele_TRRAP ------------------------------------AQSRFL------SFVNIM-AKIPA B0261.2_Cele_FRAP ----L--RVNLFFKYIFNAVR--DK-----------------N----------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -----------------------------------------L------FGENAGECV--H TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ----E--LGDEILPTLLY-IWTQHRL----------------N----------------- ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ----Q--HILTFFEVIFNAIF--DP-----------------K----------------- SMG1_Mmus_SMG1 -------LV-KQLDNILAAVH--DV-------------LNESS----------------- TRRAP_Mmus_TRRAP --------------------------------------IKTL------SFLAYI-IR--I smg-1_Cele_SMG1 --------------------------------------LPNSSISVYNHCLKGF-VL--V TOR1_Scer_FRAP ----Q--YLNSILDNIWRALR--DP-----------------H----------------- TOR2_Scer_FRAP ----P--YVNSILDNIWVPLR--DA-----------------K----------------- TRA1_Scer_TRRAP --------------------------------------IKAT------SFLAYVFIR--G ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 -------GK-ESIETLFRNRF--HP-----------------K----------------- Tor_Ddis_FRAP ----V--HASSFVDLIWVALK--DP-----------------K----------------- TRRAP_Ddis_TRRAP --------------------------------------VKTL------YLLAYV-LK--W ATMa_Spur_ATM ----K--LGEESLTCLLL-AWRSNT-----------------A----------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP --------------------------------------IKTL------SFLAYI-IK--I CC1G_00839_Ccin_ATM -------------------LW--GVKDKRLKEKILIVLRALF------PFIL---VEEPV CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ----P--HIGIVFDNILLPLR--DP-----------------R----------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ASST-------------------------------------------------------- CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ----V--HVPEFVDAIWIALR--DP-----------------R----------------- SMG1_Smoe_SMG1 -------LK-REIET--------------------------------------------- GK008_Glam_FRAP ---AIDISSEEFLEPIWHVIT--ET-----------------RN---------------- GK009_Glam_PIKK-Unclassified ----A--HRAASSANPWLPPA--DP-----------------A----------------- TRRAP_Hsap_TRRAP Y-QELVTKYSQQ----MVKGML----------------QLL-------SN--CPAETAH- SMG1_Hsap_SMG1 ---------------------------------------------------------KLL FRAP_Hsap_FRAP ---------------------------------------------------------QAI mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP F-QEVVIASSLS----VTSGML----------------NLM-------KN--CPKEAAH- CG6535_Dmel_ATM ---------------------------------------------------------DDT CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ---------------------------------------------------------QAI DNAPK_Mmus_DNAPK ----------------ALDLLI----------------KLLQIL----RS-T--RLMDE- ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ---------------------------------------------------------DSL C47D12.1_Cele_TRRAP F-MDLIMQNGPL----LVSGTM----------------QML-------ER--CPADLIS- B0261.2_Cele_FRAP ---------------------------------------------------------PAV atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR F-DELVLFWPHC----RSQLED----------------KLK-------ND--CSMTENC- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ----------------ILNTLI----------------RNL-------KD---------- ATM_Hsap_ATM ---------------------------------------------------------DSL ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ----------------ALDLLI----------------KLLQTF----RS-S--RLMDE- TOR_Dmel_FRAP ---------------------------------------------------------PAI SMG1_Mmus_SMG1 ---------------------------------------------------------KLL TRRAP_Mmus_TRRAP Y-QELVTKYSQQ----MVKGML----------------QLL-------SN--CPAETAH- smg-1_Cele_SMG1 A-NTFPNVYAAM----FESTLR----------------AIL-------TN--LPDFNSHE TOR1_Scer_FRAP ---------------------------------------------------------LVI TOR2_Scer_FRAP ---------------------------------------------------------LII TRA1_Scer_TRRAP YAPEFLQDYVNF----VPDLII----------------RLL-------QD--CPSELSS- ATR_Ddis_ATR ---------VSTASISDINQIV----------------KLISYL---IE----------- DNAPK_Ddis_DNAPK ----------------AFGPIK----------------KILHLMSRVLKQGS--IVAES- SMG1_Ddis_SMG1 ---------------------------------------------------------NNI Tor_Ddis_FRAP ---------------------------------------------------------VAI TRRAP_Ddis_TRRAP H-IEQIKQYSDR----FPRSVI----------------QLL-------QN--CPAHSSAI ATMa_Spur_ATM ---------------------------------------------------------QAI ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ----------------MLNLMK----------------KVLQ------------------ FRAP_Spur_FRAP ---------------------------------------------------------QAI SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP Y-QDLVNSYAPQ----MVKGML----------------GLF-------GN--CPSEVAH- CC1G_00839_Ccin_ATM F-QEGTRNGTLN----LVEGLQ----------------KLW-------AT--LSGEADS- CC1G_08126_Ccin_ATR ----------------LTEGLL----------------ALIQMM----FATQSPSIYHY- CC1G_00894_Ccin_FRAP ---------------------------------------------------------LHV CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------KHHAEP----VIVGIG----------------TML-------AG--APGM---- CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ----------------LVSSAL----------------RIL-------QD--CPSNGNT- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ---------SYRVQSAVVRNLSRLLAHSFEGDARDIWVKCLDV----FP----------- DNAPK_Smoe_DNAPK --------------------------------------------DKDLD-TN--A----- FRAP_Smoe_FRAP ---------------------------------------------------------QAI SMG1_Smoe_SMG1 ----------------------------------------------------------LS GK008_Glam_FRAP ---------------------------------------------------------SNI GK009_Glam_PIKK-Unclassified ---------------------------------------------------------AFP TRRAP_Hsap_TRRAP -------------LRKELL--------------------------IA--AK--------- SMG1_Hsap_SMG1 QELR-QE-G-----------------------------------------ACCLGLLCAS FRAP_Hsap_FRAP R-----E-GAVAAL------------------------------------RACLILTTQ- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP -------------LRKELL--------------------------IA--AR--------- CG6535_Dmel_ATM R-----N-LFFQCV------------------------------------SKSLHSM--- CG4549_Dmel_SMG1 PPVL-EE-C-----------------------------------------SKTLGLI-GF FRAP_Mmus_FRAP R-----E-GAVAAL------------------------------------RACLILTTQ- DNAPK_Mmus_DNAPK -------------FKIGEL---FNKFYGELASKSKLPDTVLEKVY--------------- ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM K-----E-VIIELI------------------------------------QLQIYIH--- C47D12.1_Cele_TRRAP -------------VRREVL--------------------------MA--LK--------- B0261.2_Cele_FRAP R-----I-AGIDAL------------------------------------HVVLTIVSQ- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -------------LRAGLT--------------------------IL--KY--------- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR -------------QRRNNI----------------------------------------- ATM_Hsap_ATM K-----E-VIIELF------------------------------------QLQIYIH--- ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK -------------FKIGEL---FSKFYGELALKKKIPDTVLEKVY--------------- TOR_Dmel_FRAP R-----E-SAGEAL------------------------------------RAALIVTAQ- SMG1_Mmus_SMG1 QELR-QE-G-----------------------------------------ACCLGLLCAS TRRAP_Mmus_TRRAP -------------LRKELL--------------------------IA--AK--------- smg-1_Cele_SMG1 K-----NFELLIDT------------------------------------V--------- TOR1_Scer_FRAP R-----I-DASITL------------------------------------AKCLSTLRN- TOR2_Scer_FRAP R-----L-DAAVAL------------------------------------GKCLTIIQD- TRA1_Scer_TRRAP -------------ARKELL--------------------------HA--TR--------- ATR_Ddis_ATR ----------------------------------KIPN---------------------- DNAPK_Ddis_DNAPK -------------FGVSEM---TQLFLLQFTCG-KLTQTVRGEII--------------- SMG1_Ddis_SMG1 R-----E-TVLSSL------------------------------------QSILIPDLSD Tor_Ddis_FRAP R-----E-GAVEAL------------------------------------RACLELISE- TRRAP_Ddis_TRRAP R-----K-ELLVTL------------------------------------R--------- ATMa_Spur_ATM R-----D-ELVTFL------------------------------------RLQMSVH--- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP R-----E-AAVSAL------------------------------------RACLELTAQ- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -------------LRKELL--------------------------IA--AR--------- CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR --------------MRDSVKIVF---------------CRLVDIGYTLGLW--------- CC1G_00894_Ccin_FRAP R-----E-GAADLL------------------------------------ANCLEIVCS- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP -------------LRKEPV--------------------------WP--AK--------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------L---F------------------------------------- AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ----------------------------------LHPD---------------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP R-----E-HAVEAL------------------------------------RACLTVIVT- SMG1_Smoe_SMG1 RSLAGKK-G-----------------------------------------AMG------L GK008_Glam_FRAP K-----E-VGFKAI------------------------------------NKFIS---Y- GK009_Glam_PIKK-Unclassified R-----LLTASDTF------------------------------------QVLLTCR--- TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 LSYEAEK---IFKWI-F--------S---K--FSS-----------------SAKD---- FRAP_Hsap_FRAP --REPKEMQ-KPQWY-R--------H---T--FEEAEKGFDETLA---KEKGMNRD---- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ---YLKMDMCDFNTLGVPVHEKWPQTLLRL--KTI------------------------- CG4549_Dmel_SMG1 INRKSYP---IYEEFIV--------K---N--Y-K-----------------SSKR---- FRAP_Mmus_FRAP --REPKEMQ-KPQWY-R--------H---T--FEEAEKGFDETLA---KEKGMNRD---- DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ---HPQGARAPEEGAY--ESMKWKSILYNL--YDL------------------------- C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP --REAK--NK-TEWF-K--------K---C--FDEALEGQPNPS-------QKDDL---- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ---HPKGAKTQEKGAY--ESTKWRSILYNL--YDL------------------------- ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP --RESTKQSSEPQWY-R--------I---C--YDEANGSFNADLGSSKDQKGVTRD---- SMG1_Mmus_SMG1 LSYEAEK---IFKWI-F--------S---K--FSS-----------------SAKD---- TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP --RDPQ--L-TSQWV-Q--------R---L--ATSCEYGFQV-----------NTL---- TOR2_Scer_FRAP --RDPA--L-GKQWF-Q--------R---L--FQGCTHGLSL-----------NTN---- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 TINNTKE----------------------------------------------------- Tor_Ddis_FRAP --RESR--L-RLQWY-Q--------K---I--YDEAQKSFKQNG----------SP---- TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ---HPKGVMTEEQGAYAGDFDQWKNQLTSL--YEE------------------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP --RETKEMQ-KPQWY-K--------Q---T--YEEAEKGFEETGK---GEKGLNRD---- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP --RERQ--TR-NPYL-Y--------K---I--LQDAQAGLKS-----------SQP---- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP --RETR--WR-VRWY-Y--------R---M--FEATQDGLGKN----------ATV---- SMG1_Smoe_SMG1 VEAEVVS---LLK------------------------------------------F---- GK008_Glam_FRAP --QKKA--TK-HDVL-V--------R---L--ITMIRAALDGK-------NISEQL---- GK009_Glam_PIKK-Unclassified --RARKLAD-ADSLM-C--------R---LSDVQAV-------------------TDRIN TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 -----------------------EVK---LLYLCATYKALET--VGEKKAFSSVMQLVMT FRAP_Hsap_FRAP -----------------------DRIHGALLI------------LNE------------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 -----------------------MQK-----YMIMALRATLS--CDTKCELHMYADKIML FRAP_Mmus_FRAP -----------------------DRIHGALLI------------LNE------------- DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP -----------------------DRWHAVALI------------LNE------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP -----------------------DRIHGGLVV------------FNE------------- SMG1_Mmus_SMG1 -----------------------EVK---LLYLCATYRALET--VGEKKAFSSVMQLVMT TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP -----------------------ECIHASLLV------------YKE------------- TOR2_Scer_FRAP -----------------------DSVHATLLV------------FRE------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ---------------------------------------------------------NIE Tor_Ddis_FRAP -----------------------ESIHGSLIT------------VSE------------- TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP -----------------------DRAHGALLI------------INE------------- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP -----------------------EVIHGSLAA------------YRE------------- CC1G_06302_Ccin_PI3K -----------------------------------LIADNKPLTIPYRTPF-KAF----- CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ----------------------------AFII------------LTQ------------- CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -----------------------ESIHGSLLA------------VGE------------- SMG1_Smoe_SMG1 -----------------------D-----LLLLLMSVRANAA--------E-SQVQKVKS GK008_Glam_FRAP -----------------------I----ALHL------------LLN------------- GK009_Glam_PIKK-Unclassified GVAAAELRNATVLVGLFSACIAPD------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 SLQSILENVDTPE--LLCKCVKCILLVARCYP---------------------------- FRAP_Hsap_FRAP --------------------------LVRISSME---------GERLREEMEEIT---QQ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM --------------------------VNVEIRKNSWARCKNALLS--------------- CG4549_Dmel_SMG1 LLKDFLENAESAD--IFIVVSNTLVQFAASYA---------------------------- FRAP_Mmus_FRAP --------------------------LVRISSME---------GERLREEMEEIT---QQ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM --------------------------LVNEISHI---------GSRGKY----------- C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP --------------------------LLRISDQR---------FELIRCESSQFI---KQ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM --------------------------LVNEISHI---------GSRGKY----------- ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP --------------------------LFRCANAT---------WERRYTSLKTLF----P SMG1_Mmus_SMG1 SLQSILENVDTPE--LLCKCVKCILLVARCYP---------------------------- TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP --------------------------ILFLK----------------------------- TOR2_Scer_FRAP --------------------------LLSLK----------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 YFYNMII--DENNYIL---KLLLLNIINDTKRN--------------------LVVYNYN Tor_Ddis_FRAP --------------------------LLRNT----------------------------- TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM --------------------------LVREWRQE---------GSKLKL----------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP --------------------------LIRTSSRE---------GERLRQEMEEVS---QQ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP --------------------------LLLHAG---------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K --------------------------LF------------------------------PA CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP --------------------------LLRNTG---------------------------- SMG1_Smoe_SMG1 IINFVLEKSDPF------------------------------------------------ GK008_Glam_FRAP --------------------------ML------------------------------NL GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP QLVHDKYCKDLMG-------FGTKP------RHITPFTSFQAVQPQQSNALVGLLGYS-S mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP QLVHDKYCKDLMG-------FGTKP------RHITPFTSFQAVQPQQPNALVGLLGYS-S DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP KFL-----KEDE-------EEG-------------------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP KTQHNKFLEASSSSSMGSQLNTLVP------RLKVPFID--------------KLGSTQT SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 Q------------------------------QH--------------------------- Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP QTQHEHSFRDLGS-------SSNKAKSPTGPQ--------------LGHNQYVQRALA-S SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K IHGLYRALISTSYTWTLSHWNTLT------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP -------HQGLMGFGTSPSPAKSTLVESRC------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP -------PQGLMGFGTSPSPAKSTLVESRC------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP -------VEW------LVLTKQQTIVESVT------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP HLGEGEHHKG------VAKFASHNVLESAY------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP -------PLSLVATGIQPK---PRITESRY------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------LGLQRL------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------SVKDKS------------------------------ GK009_Glam_PIKK-Unclassified -----------------------------SLAALVANRGSHFCHLAAGLGLPNQVEGQRL TRRAP_Hsap_TRRAP -------------------------------------------------HILTTE----- SMG1_Hsap_SMG1 -------------------------------------------------HIFSTN----- FRAP_Hsap_FRAP -----------------------------------------------CRDLMEEK----- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP -------------------------------------------------HIFATD----- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 -------------------------------------------------ETFECH----- FRAP_Mmus_FRAP -----------------------------------------------CRDLMEEK----- DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP -------------------------------------------------YFTSGE----- B0261.2_Cele_FRAP -----------------------------------------------ARKLVLER----- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -------------------------------------------------KKLHNS----- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP -----------------------------------------------AQEILQEH----- SMG1_Mmus_SMG1 -------------------------------------------------HIFSTN----- TRRAP_Mmus_TRRAP -------------------------------------------------HILTTE----- smg-1_Cele_SMG1 -------------------------------------------------MRF-------- TOR1_Scer_FRAP ------------------------------------------------DPFLNQV----- TOR2_Scer_FRAP ------------------------------------------------APYLRDK----- TRA1_Scer_TRRAP -------------------------------------------------HILSTN----- ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 -------------------------------------------------QLPIQNTSSPN Tor_Ddis_FRAP ------------------------------------------------GDFMLSK----- TRRAP_Ddis_TRRAP -------------------------------------------------HILSSD----- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP -----------------------------------------------CLELMQEN----- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -------------------------------------------------HILGTD----- CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR -------------------------------------------------M---------- CC1G_00894_Ccin_FRAP -------------------------------------------------MFMQEN----- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K -----------------------------------------------CSASAITR----- CC1G_00331_Ccin_TRRAP -------------------------------------------------I---------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -------------------------------------------------EFMMSR----- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP -----------------------------------------------IADYFQEN----- GK009_Glam_PIKK-Unclassified GSVSEVSKSILDTLYAHDTLRKLSAFTNRIYMKAYKRFVLIHVVFAYFDDWLHAD----- TRRAP_Hsap_TRRAP --------LR---------------------------------------------NQFIP SMG1_Hsap_SMG1 --------FR-------------------------------------------------- FRAP_Hsap_FRAP --------FD-------------------------------------------------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP --------LR---------------------------------------------QKFIP CG6535_Dmel_ATM ---------------NNKFSDPFIKMSALAMYIVL------------------------- CG4549_Dmel_SMG1 --------FT-------------------------------------------------- FRAP_Mmus_FRAP --------FD-------------------------------------------------- DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ---------S-SGSRNIAVKENLI--------DLMADICYQLFDADTRSVEIS------- C47D12.1_Cele_TRRAP --------MK---------------------------------------------SKFFP B0261.2_Cele_FRAP --------FP-------------------------------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR --------I--------------------------------------------------L TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ---------S-SGFRNIAVKENLI--------ELMADICHQVFNEDTRSLEIS------- ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP --------YT-------------------------------------------------- SMG1_Mmus_SMG1 --------FR-------------------------------------------------- TRRAP_Mmus_TRRAP --------LR---------------------------------------------NQFIP smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP --------FD-------------------------------------------------- TOR2_Scer_FRAP --------YD-------------------------------------------------- TRA1_Scer_TRRAP --------YK---------------------------------------------KLFLP ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 TPSSTTTTT--------------------------------------------------- Tor_Ddis_FRAP --------FK-------------------------------------------------- TRRAP_Ddis_TRRAP --------FK---------------------------------------------SKFIV ATMa_Spur_ATM ---------KGAGKRDVNFKQDLV--------ELAADVCHQIFNAGLVSYEVSLQGSQVP ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP --------FD-------------------------------------------------- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP --------LR---------------------------------------------NKFVP CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP --------FL-------------------------------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K --------LN-------------------------------------------------- CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP --------YK-------------------------------------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP --------YS-------------------------------------------------- GK009_Glam_PIKK-Unclassified --------YG-------------------------------------------------- TRRAP_Hsap_TRRAP CMD-----------------KLFDESI-------------LIGSGY----------TARE SMG1_Hsap_SMG1 ------------------------DTV-----------DILVGWH----------I--DH FRAP_Hsap_FRAP ------------------------QVC-----------QWVLKC----------RN---- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP SIE-----------------QLFDEDL-------------LIGKGV----------T-LD CG6535_Dmel_ATM ---------------------WHLE----------------------------------T CG4549_Dmel_SMG1 ------------------------DVV-----------DIVIGWQ----------L--EA FRAP_Mmus_FRAP ------------------------QVC-----------QWVLKC----------RS---- DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM --------------------QSY------------------------------------- C47D12.1_Cele_TRRAP MLP-----------------RLIAEEV-------------VLGTGF----------TAIE B0261.2_Cele_FRAP ------------------------KIL-----------DCVRQIIPLANKTSSTKQ---- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR DQA-----------------LFIDELF-------------ATFNSL----------TAKK TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM --------------------QSYT------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------SIC-----------DNVLEQ----------RT---- SMG1_Mmus_SMG1 ------------------------DTV-----------DILVGWH----------I--DH TRRAP_Mmus_TRRAP CMD-----------------KLFDESI-------------LIGSGY----------TARE smg-1_Cele_SMG1 ----SDQLNEKPH----------------------------------------------- TOR1_Scer_FRAP ------------------------QMC-----------LNCIAY----------EN---- TOR2_Scer_FRAP ------------------------DIY-----------KSTMKY----------KE---- TRA1_Scer_TRRAP KLD-----------------YLFDERI-------------LIGNGF----------TMHE ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 --------------------------TTSTKPSKRGDKERERGR-----------RNKDK Tor_Ddis_FRAP ------------------------DIC-----------ETVLKY----------KD---- TRRAP_Ddis_TRRAP YLD-----------------LLLDEK-------------IILGTS----------RTSYE ATMa_Spur_ATM STS-----------------RLMS------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------IVC-----------QQVLKF----------CG---- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP SID-----------------KLFEEHV-------------LVGSGW----------TSKE CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------DTA-----------EAILRF----------KS---- CC1G_06302_Ccin_PI3K --------------------------------------KNSYTWN--------------- CC1G_04234_Ccin_PI4K --PRLTAIMGDVAIEQGRAEEDFDDR-------------TAVG------------PRSED CC1G_13883_Ccin_PI4K ------------------------QLC-----------ADII------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------EVL-----------DIAFKF----------RD---- SMG1_Smoe_SMG1 --------------------------------------EAPVRWH--------------- GK008_Glam_FRAP ------------------------SFF-----------SLVANI----------FR---- GK009_Glam_PIKK-Unclassified ------------------------RVC-----------AELVSS----------YSS--- TRRAP_Hsap_TRRAP -------------TL-------------------RPL-AY---------------STLAD SMG1_Hsap_SMG1 -------------TQ-------------------KP-SLTQQVSG--------WL----- FRAP_Hsap_FRAP --------------S-------------------KNSLIQMTILN--------LL---P- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP -------------SI-------------------RPL-AY---------------STLAD CG6535_Dmel_ATM KKADENGEGDAPKKIPKPADKMETIFSLIDKKENT-----FND-V--------WLAIFTE CG4549_Dmel_SMG1 -------------GQ-------------------PT-DLKTHCAQ--------VL----- FRAP_Mmus_FRAP --------------S-------------------KNSLIQMTILN--------LL---P- DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM VTQRESTDYSVPCKRRKIDVGWEVIKDYLQKSQSD-----FDLVP--------WLQITTR C47D12.1_Cele_TRRAP -------------HL-------------------RVF-MY---------------QMLAD B0261.2_Cele_FRAP --------------Q-------------------SSIYLNTVLMQ--------LL---P- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -------------ST-------------------NHM-TF---------------PKLLN TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM TTQRESSDYSVPCKRKKIELGWEVIKDHLQKSQND-----FDLVP--------WLQIATQ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP --------------S-------------------KSPYVQQALLQ--------IL---P- SMG1_Mmus_SMG1 -------------TQ-------------------KP-SLTQQVSG--------WL----- TRRAP_Mmus_TRRAP -------------TL-------------------RPL-AY---------------STLAD smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP --------------H-------------------KAKMIREKIYQ--------IV---P- TOR2_Scer_FRAP --------------Y-------------------KFDVIRREVYA--------IL---P- TRA1_Scer_TRRAP -------------TL-------------------RPL-AY---------------STVAD ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 -------------IN-------------------EK-QLQQQQLQ--------QL----- Tor_Ddis_FRAP --------------H-------------------RDKLVKKTVLA--------LF---P- TRRAP_Ddis_TRRAP -------------SL-------------------RSMA----------------YGSLAD ATMa_Spur_ATM SQMRLTSQVTTPSKRRRLESGWELLREYISQPLQH-----ASIIP--------WLQLLAA ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP --------------S-------------------RNPLIQQILLN--------LL---P- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -------------SL-------------------RPL-AY---------------STLAD CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP --------------S-------------------RDPLVRRMVIT--------MI---P- CC1G_06302_Ccin_PI3K --------------------------------------------E--------------- CC1G_04234_Ccin_PI4K -------------DL-------------------APPA----------------VSAR-- CC1G_13883_Ccin_PI4K ------------------------------------HKDGLDTEE--------IFYAQA- CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP --------------H-------------------RDRLVRRSITS--------LL---P- SMG1_Smoe_SMG1 --------------------------------------------SELQLAVVQA------ GK008_Glam_FRAP --------------S-------------------KTSEGRMLVAS--------II---S- GK009_Glam_PIKK-Unclassified ----------------------------------SPSSLQHNI----------------- TRRAP_Hsap_TRRAP LVHHVRQHL-------------PLSD---------------------------------- SMG1_Hsap_SMG1 --QSLE-PF-------------WVAD---------------------------------- FRAP_Hsap_FRAP ---RLA------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP LAHHVRQSL-------------NIDV---------------------------------- CG6535_Dmel_ATM ILQLSSVIL-------------NVAN---------------------------------- CG4549_Dmel_SMG1 --EQLT-PF-------------FSKQ---------------------------------- FRAP_Mmus_FRAP ---RLA------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM LISKYPSSL-------------PNCE---------------------------------- C47D12.1_Cele_TRRAP LLHHMRNSI-------------DYEM---------------------------------- B0261.2_Cele_FRAP ---RIC------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR EIQHFLQDHGKVLIMHKELRQKPVQW---------------------------------- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM LISKYPASL-------------PNCE---------------------------------- ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ---RLA------------------------------------------------------ SMG1_Mmus_SMG1 --QSLE-PF-------------WVAD---------------------------------- TRRAP_Mmus_TRRAP LVHHVRQHL-------------PLSD---------------------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ---LLA------------------------------------------------------ TOR2_Scer_FRAP ---LLA------------------------------------------------------ TRA1_Scer_TRRAP FIHNIRSEL-------------QLSE---------------------------------- ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 --QL-------------------------------------------------------- Tor_Ddis_FRAP ---RLA------------------------------------------------------ TRRAP_Ddis_TRRAP FIHNMRNEL-------------NINQ---------------------------------- ATMa_Spur_ATM IVTKYPKDL-------------PEEE---------------------------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ---RLA------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP LVHHVRQQL-------------PLQH---------------------------------- CC1G_00839_Ccin_ATM ---RWGTNGL------------KLSTLRLQIIRAGDPRNDTSNPFIASTFRSGWDFDIDQ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ---TLA------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ---FLA------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ---RIA------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ---LFA------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------LSLAVQL----------------------------------------- SMG1_Hsap_SMG1 ------------LAFSTTL----------------------------------------- FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------LIKAVNL----------------------------------------- CG6535_Dmel_ATM ------------YQMALTTV---------------------------------------- CG4549_Dmel_SMG1 ------------IDFSYG------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------LSPLILIL---------------------------------------- C47D12.1_Cele_TRRAP ------------ITHVIFV----------------------------------------- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------LIIYLEL----------------------------------------- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------LSPLLMIL---------------------------------------- ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------LAFSTTL----------------------------------------- TRRAP_Mmus_TRRAP ------------LSLAVQL----------------------------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------IEKTIKI----------------------------------------- ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ---------------QQQLDHEGSSLYLPFSSLLSFIKPDKQQQPQQSQQSQLNEIDQMV Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------ISKVVAI----------------------------------------- ATMa_Spur_ATM ------------YALFVSAL---------------------------------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------LSMAVHL----------------------------------------- CC1G_00839_Ccin_ATM ALAWGILELQADVAKQLFM----------------------------------------- CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ----------------------------------------------------------FA SMG1_Hsap_SMG1 ---------------------------------------------L-------------G FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ----------------------------------------------------------FS CG6535_Dmel_ATM -----------------------------------------------------------A CG4549_Dmel_SMG1 --------------------------------------------LL-------------D FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM -----------------------------------------------------------Y C47D12.1_Cele_TRRAP ----------------------------------------------------------FC B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ----------------------------------------------------------SC atl-1_Cele_ATR ---------------------------------------------IDDANDKFGLLENFS TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM -----------------------------------------------------------S ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ---------------------------------------------L-------------G TRRAP_Mmus_TRRAP ----------------------------------------------------------FA smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ----------------------------------------------------------YT ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 RPKSLPKDDNDSDNFNIRVLEYNLKLLIKIYFKVSMYQDSIKTHIF-------------D Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ---------------------------------------------Y-------------S ATMa_Spur_ATM -----------------------------------------------------------H ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ----------------------------------------------------------FS CC1G_00839_Ccin_ATM ----------------------------------------------------------FA CC1G_08126_Ccin_ATR ----------------------------------------------------------DV CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ----------------------------------------------------------LS AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ----KN----------------------IDDES-----LPSSIQTMSCKLLLN-----L- SMG1_Hsap_SMG1 ----QFLEDMEAYAEDLSHVASGE---SVDEDV-----PPPSVSLPKLAALLR-----VF FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ----KN----------------------VHDES-----LAVGIQTMSCKLLLN-----L- CG6535_Dmel_ATM EIMQM---------------------------YGNAKNL-----RNLRLCLAHLLTKEQ- CG4549_Dmel_SMG1 ----QFVEDITTLEEG-----------------------EPANTAERVGAFVG-----AF FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM QLLPQ---------------------------QRRGERI-----PYVLRCLKE-----V- C47D12.1_Cele_TRRAP ----RT----------------------LHDPN-----NSSQVQIMSARLLNS-----L- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ----LL----------------------LLDLS-----TNHDIHEFPARLCMT-----A- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ---------------------------------------------MKNDTIF-------- ATM_Hsap_ATM QLLPQ---------------------------QRHGERT-----PYVLRCLTE-----V- ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ----QFLEDMEAYAEDLSHVASGE---SVDEDV-----PPPSVSLPKLAALLR-----VF TRRAP_Mmus_TRRAP ----KN----------------------IDDES-----LPSSIQTMSCKLLLN-----L- smg-1_Cele_SMG1 -------------------------------------------------LAEE-----M- TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ----GY----------------------LLDES-----LALTVQIMSAKLLLN-----L- ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ----LYIQINQAISEQQRQLQEKEKESKTSKPI-----PQPIIS--------L-----VI Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ----RH----------------------LHDQT-----NPVSIQIMSVKLIIS-----L- ATMa_Spur_ATM NLQAH---------------------------SKRSQLQ-----SHVLRCLQC-----I- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ----KN----------------------VHDES-----LPCNIQTMSCKLLLN-----L- CC1G_00839_Ccin_ATM ----ES----------------------MH------------------------------ CC1G_08126_Ccin_ATR ----VE----------------------PDDEI-----QP-----SPGKLRNS------- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ----AL----------------------LFNTS-----LGFNLHILFAKVIFG-----L- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM -------------------------------------------------C---------- ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 --------------------------------------------------LRR-----VF GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP VD-CIRS---K-SEQESG-NGRDV-L---------------------------------- SMG1_Hsap_SMG1 ST---------------------------------------------------------- FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP VD-CLRH---H-SETEPQ-RSKAL-L---------------------------------- CG6535_Dmel_ATM EL-LHS----------KS-IREDFLG---------------------------------- CG4549_Dmel_SMG1 NT---------------------------------------------------------- FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK --------------------------ELLGVLGEVH---P----------SEMINHSE-- ATR_Mmus_ATR --------------------------------------QNEAKDS--------------- ATM_Mmus_ATM AL-CQGK---K-SNLESS-QKSDL-L---------------------------------- C47D12.1_Cele_TRRAP AE-SLCK---M-DSHD---TTRDL-L---------------------------------- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM RT-SLAR---GNSG---------------------------------------------- atl-1_Cele_ATR SEICMRR---I-KHSIQS-THTDC-L---------------------------------- TEL1_Scer_ATM --------------------------------------LSENRLS--------------- MEC1_Scer_ATR ---------------------SKT-VSALALLLEYN-------------PFLLVMKDSN- ATM_Hsap_ATM AL-CQDK---R-SNLESS-QKSDL-L---------------------------------- ATR_Hsap_ATR --------------------------------------SHEAKGS--------------- DNAPK_Hsap_DNAPK --------------------------ELLGLLGEVH---P----------SEMINNAE-- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ST---------------------------------------------------------- TRRAP_Mmus_TRRAP VD-CIRS---K-SEQESG-NGRDV-L---------------------------------- smg-1_Cele_SMG1 VR-IIRP---D-IKKNGLGNMREL-K---------------------------------- TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP VE-RILKLGKE-NPQEAP-RAKKL-L---------------------------------- ATR_Ddis_ATR SS-LA---------------------------------IGDSSGD--------------- DNAPK_Ddis_DNAPK --------------------------VVLGLFTEYF---S----------SNMCDRNQ-- SMG1_Ddis_SMG1 PT---------------------------------------------------------- Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP MD-VIQR---K-QDPPEY-KSRSI-I---------------------------------- ATMa_Spur_ATM AA-SQES---R-QKFSQH-TKDQL-S---------------------------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP VE-CIRQ---K-SEQDGA-NAREI-L---------------------------------- CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR -----VL---E--------VLAEV-LSGLP---KPFPRLPAPARSISSDQ--------FA CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K -W---------------------------------------------------------- CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP TD-AIVA---K-EVP--Q-TAAKL-L---------------------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR RS---------------------------------------------------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 SW---------------------------------------------------------- GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR --------------------ASSWIT---------------------------------- CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ---------------NLFRAFL----GE------LKTQMTSTVREPKFPV---------- ATR_Mmus_ATR -----------------CIEFSHWIIT-------------RLLRIAATPSCHMLHKK--- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM -----------------TI-------S-------------YVLRLFVEKSCERFKVK--- MEC1_Scer_ATR --GNFEIQRLI---DD-----------FLNISVLNYD------N--YHRI---------- ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR -----------------CIEFSNWIIT-------------RLLRIAATPSCHLLHKK--- DNAPK_Hsap_DNAPK ---------------NLFRAFL----GE------LKTQMTSAVREPKLPV---------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR -----------------ICFFLFKLIP-------------FLSHKSSTNICSQQHQQLDE DNAPK_Ddis_DNAPK ---------------QLSFIFM----ET------LGGQLRSK--SPESTL---------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR -----------------------------------------------------LDKK--- DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR EAQKFQNPEALKVLRE-----------MVNEVVELTDIVQLYLG--T------------- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR -------ICEVICSLLF------------------------------------------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM -------TLKLLLAVVP--------------------------------EL--------- MEC1_Scer_ATR -------------------------------------------------------WFMRR ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR -------ICEVICSLLF------------------------------------------- DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR NEEFTENLITAIKAMLN------------------------------------------- DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR -------LQKF------------------------------------------------- DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR --------------------------------------------------I--------- AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ---ARKAFCSQLRGLLTQEHIWYSTVGHKSGDYEILKKLGDALAIATDPDVLETLMETVA DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP --MR---MLEVFVLKFH--TIARYQLSAIFKKCKPQSEL--------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP --SK---LLKVFVKKFE--TIAKIQLPLIIQKCKGHAFS--------------------- CG6535_Dmel_ATM --EL---WSQM-----------------A------------------------------- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK --------LAGCL---K--GLSSLL----------------------------------- ATR_Mmus_ATR -------L---------------------------------------------------- ATM_Mmus_ATM --KL---WIKIWSITFR--GISSGQTQTE------------------------------- C47D12.1_Cele_TRRAP --IE---ILESHVAKLK--TLAVYHMPILFQQYGTEIDYEYKSYE-------------RD B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM --------------------------------------------DEWTKKTVQRVRKEH- atl-1_Cele_ATR --AD---YLDILA-SLL--KLARIQKL--------------------------------- TEL1_Scer_ATM -------M---------------------------------------------------- MEC1_Scer_ATR KLGS---WCKACVEFYG--KPAKFQ----------------------------------- ATM_Hsap_ATM --KL---WNKIWCITFR--GISSEQIQAE------------------------------- ATR_Hsap_ATR -------L---------------------------------------------------- DNAPK_Hsap_DNAPK --------LAGCL---K--GLSSLL----------------------------------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP --MR---MLEVFVLKFH--TIARYQLSAIFKKCKPQSEL--------------------- smg-1_Cele_SMG1 --KRMKLTMALVKMAKSQKM---------------------------------------- TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP --MI---IIDSYMNRFK--TLNR-QYDTIMKYYG-RYET--------------------- ATR_Ddis_ATR -------F---------------------------------------------------- DNAPK_Ddis_DNAPK --------IQSCL---K--GLNSLL----------------------------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP --YK---VIESFINKFS--S---------------------------------------- ATMa_Spur_ATM --RE---WSKVWSATIR--TICLHSAEDE------------------------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP --MR---MLEVFVLKFH--TIADNQLPVIFDKCRQQQE---------------------- CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP --SS---MLETCLERLE--GLCTVQ----------------------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR -------A---------------------------------------------------- AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR EVGK---V---------------------------------------------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP GAVEAA----------LPGVP--------------------------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP G----------------------------------------------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK --------------------------------CNFTKS-MEEDPQTSKEIFGFTFKAIRP ATR_Mmus_ATR --------------------------------FK---S---------------------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP A----EKPGMNIPKDTIRG----------------------------------------- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM --------------------------------VK---D---------------------- MEC1_Scer_ATR --------------------------------LTA------------------------- ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR --------------------------------FK---S---------------------- DNAPK_Hsap_DNAPK --------------------------------CNFTKS-MEEDPQTSREIFNFVLKAIRP TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP GAAEAA----------LPGVP--------------------------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP HK---------------------------------------------------------- ATR_Ddis_ATR --------------------------------LN---D---------------------- DNAPK_Ddis_DNAPK --------------------------------VHFSGDFIASDPKNVQLIYQYVYICLDP SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP AAQEKM----------LPPVSRSISVSSATASS--------------------------- CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP --------------------------------ADVSQ----------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR --------------------------------ID---G---------------------- AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR --------------------------------AKGDEL---------------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR -------------------------------NPDVGH----------------------- CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK QIEMKRYAVPLAGLRLLTLHASQFTACLLDNYITLFEVLSKWCSHT-NVELKKAAHSALE ATR_Mmus_ATR ------------------------------KNPAIFG----------------------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------GSKSLLD----------------------- MEC1_Scer_ATR --------------------------------------HF-------------------- ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------KSPAIFG----------------------- DNAPK_Hsap_DNAPK QIDLKRYAVPSAGLRLFALHASQFSTCLLDNYVSLFEVLLKWCAHT-NVELKKAALSALE TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------D-ANVLL----------------------- DNAPK_Ddis_DNAPK ASSTQRFEIPRAAMKIVARHAVLLRQYLAEHSQPFYTRIEHWCNHI-NKLNRDIAFTAVD SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP --------------------------------------ALERIRSGSQEVTV-------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ----------------------------------------------------EKLKEKLQ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------R-VSATI----------------------- DNAPK_Smoe_DNAPK ------------LSQSM--------------------------------ALLGSA----- FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR -------------YAQLT---------------------------------------LEA CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK SFLRQISFTVAE---DAELHKSRLKY-------------------FMEQFYGIIR-NTDS ATR_Mmus_ATR -------------VLTRE----LLYL-------------------FEDLIYLHKRN-AVG ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM -------------AVSVH----LSFA-------------------LDALIKSDPFK-LKF MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR -------------VLTKE----LLQL-------------------FEDLVYLHRRN-VMG DNAPK_Hsap_DNAPK SFLKQVSNMVAK---NAEMHKNKLQY-------------------FMEQFYGIIR-NVDS TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR -------------LFFK----ETICL-------------------FKDCIDFIKCLNSSN DNAPK_Ddis_DNAPK SFFQQISKELTSGNRSLEADQSTFKF-------------------FIRKFYSIFE-NNNS SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ----------------------------------------------IHVLSVSLND-FPL DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK SQL--------------------------------------------------------- AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR -------------LLIEQLDKSEVSARAVSVRLICEIAAAQWPSDSNRCVER-------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR TAI-M----WSAV-AKWLDM-----GCMTR-QELKRLNIT-TKLLLEVLHMRARPA---- CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK NNK-E----LAIAIRG----------YGLFAGPCKVINAK-D-------------V---- ATR_Mmus_ATR EVM-E----WPVVVSRFLSRLDEHMGCLQP-APLQFMNVQ-N-------------V---- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM MIH-Q----W-------ISLVDKICEYFQSQM---------------------KLSM--- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR HAV-E----WPVVMSRFLSQLDEHMGYLQS-APLQLMSMQ-N-------------L---- DNAPK_Hsap_DNAPK NNK-E----LSIAIRG----------YGLFAGPCKVINAK-D-------------V---- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR NQQEQEKSIFPMVLKTYC-----------------------------------ELSSSVI DNAPK_Ddis_DNAPK SRF-E----LSIAIRG----------CGRFASPVKSFMGEWE-------------L---- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR -----------------------------S-CIYQIM----------------------- DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR INSNTTGNTSSYSKHYQSLDLLVQTEMAFNQYSKNNNNNNNNNNNSEKDKNIEKEKSNSN DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------S----- CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR -------------------MVDSSSEILFEFFLK-------------------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------HHLGYLLL----------------------------NEI-LS---LPT CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------DFMYVELIQRCKQMFLTHADASEDHVYQMPSFLQSIASVLLYLDTVPE ATR_Mmus_ATR ------------EFIEVTLL----------------------------MVLIHI---VPT ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------VDKTLTNFI--SIL----------------------------LNLLAL---DTV MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------EFIEVTLL----------------------------MVLTRI---IAI DNAPK_Hsap_DNAPK ------------DFMYVELIQRCKQMFLTQTDTGDDRVYQMPSFLQSVASVLLYLDTVPE TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR DDNSKSID--------EGVI----------------------------IVISSINRLIN- DNAPK_Ddis_DNAPK ------------KSLLNSLFKFSEKLMVVKIENIDEITLHLSSFINAFACILYELNELEF SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR -AIELDDGLLETLSSYIQGQLEHSVVPLEQLVHLQQLMLSHWHCHP-THLVP-IL-ALMG CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK VY----------------------------TPVLEHLMVVQ------------ID--SFP ATR_Mmus_ATR -V---------------------------------------FFRRQELLLWQ-IGCALLE ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM -G---------------------------------------IFQVTRTITWTVIDFLRLS MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR -V---------------------------------------FFRRQELLLWQ-IGCVLLE DNAPK_Hsap_DNAPK VY----------------------------TPVLEHLVVMQ------------ID--SFP TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR --------------------------------------------LQYGLLVS-ISS-VID DNAPK_Ddis_DNAPK WY----------------------------LDHIEQVLETY------------FI--IFP SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR LKQTEMRSGVVQVLTQS---------LVEILKK----------------------EE--- CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK QYSPKMQLVCCKAIIKL--------------------------------------FLALS ATR_Mmus_ATR HGSPKIRSLAISLLTEL---------FEL-GGL----------------------PA--- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP --------------------------------VPKRRIRRLSIDSVEELEFLASEP---- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM KKENGNTRLIMSLINQLI---LKCHCFSVIDTL----------------------ML--- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR YGSPKIKSLAISFLTEL---------FQL-GGL----------------------PA--- DNAPK_Hsap_DNAPK QYSPKMQLVCCRAIVKV--------------------------------------FLALA TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR NFSPILYSVSIDLWDVLSQYLFLLNDLKLSSFK----------------------Y---- DNAPK_Ddis_DNAPK HLFVKSRDRYFKAVNRL--------------------------------------ISSLF SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR -------------------------------------------------------NL--- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP --------------------------------------TAPAAPGPAPSPAPVPAPPPPP SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK EKGPVHWNCISAVVHQGLIRICSKPV------VLQKDV----ESRSDN------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP -----------------------------------------STSEDADESGGDPNKLP-- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK AKGPVLRNCISTVVHQGLIRICSKPV------VLPKGP----ESESED------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP --------------------------------------TAPAAPGPAPSPAPVPAPAPPP smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK YHGEYLKILLSRFVKKGLLITFSKPNDSIKNLIT-------------------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -------------------------------------TTTTTTTTTSSSTASVSLPPPPP CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP P-PPP-----------------PATP-----VTPAPVPP--------------------- SMG1_Hsap_SMG1 ----------------VVRSIGERFS----PI---RG----------------------- FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ----------------LLKCLA-RMQ----IF---VG----------------------- FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP --------------------------------------PPTKEGKKTSPEAILTAMSTMT B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ----------------VVRSIGERFS----PI---RG----------------------- TRRAP_Mmus_TRRAP PPPPA-----------------PATP-----VTPAPVPP--------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ----------------VLVSIGDIIKYKYATP---SP----------------------- Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ----------------LKRSIPK------------LL----------------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP T-PTTPQTMSFASLSTTAATIPPATP-----TTP--APP--------------------- CC1G_00839_Ccin_ATM -----------------------------------------------------PATPCTS CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ----------------I------------------------------------------- CC1G_04234_Ccin_PI4K ------------------TSLDE------------DD----------------------- CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ----------------IVP----------------------------------------- GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ---FEK---------------QGE------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ---------------------------------------------ALVNSSGNASLSHIN CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP PPPL-------------------------------------------------------- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ---FEK---------------QGE------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ----------------------KEKAEKLKNSIQDNDKESEEFMRKVLEPSDDDHLMPQP ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ----------------ADQQKEKE------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ---VTPGVSSITTAPLSSLFPTRE------------------------------------ CC1G_00839_Ccin_ATM QRKD-------------------------------------------------------- CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ----------------DDQ----------------------------------------- CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP -KDKED-----------K-------------------------QTFQVTDCRSLV---KT SMG1_Hsap_SMG1 -----------PPITE-----------------------------AYVTDVLYRV---MR FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP APDLKDDISNIQVSASGSQW----------------------IYSVNVAEFRSLV---KT CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 -----------MPTCE-----------------------------CIVKMAVDHLIKIMP FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ----------------------------------------------------------RS ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ----------------------------------------------AIVEARNLV---KY B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ----------------------------------------------------------HR TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 -----------PPITE-----------------------------AYVTDVLYRV---MR TRRAP_Mmus_TRRAP -KDKED-----------K-------------------------QTFQVTDCRSLV---KT smg-1_Cele_SMG1 ------LEETNQMISEMSIELEENGGKWSSASLITIVCDVFNELLILGKDDVKLQ---KG TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP KKEDINDSPDVEMTES--DKVVKNDVEMFDIKNYAPILLLPTPTNDPIKDAFYLY---RT ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 -----------PNLTP-------------------TTTTKMEEEER-------------- Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP -KELKDPQS------------LKDKLDGLSSANTTTSSTGEIIILDPVKDTRTLI---KT ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -KDESKPKKYLPTGLTHF-------------------------NNYSVVDCRSLV---KT CC1G_00839_Ccin_ATM ----------------------------------------------KRFRLQNPV---ST CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K -----------------------------------EGSPSSEESLP-AK----------- CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP LVCGVKTITW------------------------------------GITSCKAPGEAQ-- SMG1_Hsap_SMG1 CVTAANQVFF------------------------------------SEAVLTAANECVGV FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ----V------------------------------------------------------- CG2905_Dmel_TRRAP LVGGVKTITW------------------------------------GFFNSKFQLTDT-- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------TLHL------------------------------------NTEALVNINELICI FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ASEEV------------------------------------------------------- ATR_Mmus_ATR ----Q------------------------------------------------------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP IMHTCKFVTG------------------------------------QLRIARPS------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ----I------------------------------------------------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ----Q------------------------------------------------------- DNAPK_Hsap_DNAPK ASGEV------------------------------------------------------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 CVTAANQVFF------------------------------------SEAVLTAANECVGV TRRAP_Mmus_TRRAP LVCGVKTITW------------------------------------GITSCKAPGEAQ-- smg-1_Cele_SMG1 VEESL------------------------------------------------------- TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP LMSFLKTIIH------------------------------------DLKVFNPPPNEY-- ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP MTSSLRNIFW------------------------------------SLSACPINKPGTGI ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP VVCGVKTITW------------------------------------GVSACKVSTDP--- CC1G_00839_Ccin_ATM LLHNIETQILTVPRCYHLQVLLFFVDRHWSIVHDTLKRQIMDTLIQVQNLED-------- CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ----V------------------------------------------------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------FI--PN-K-------QL---------QPKETQIYIKLVKYAM SMG1_Hsap_SMG1 LLG----SLD-----------------------------------PSMTIHCDMVITYGL FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------KLANHE-K-------IF---------GPEIVCSYIDLVYYAM CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 CLLNNFTGLD-----------------------------------PIL---LEQV---LL FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ----------------------QDM--------YH---------CSKERDLFERLLRYGV B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 LLG----SLD-----------------------------------PSMTIHCDMVITYGL TRRAP_Mmus_TRRAP ------------------FI--PN-K-------QL---------QPKETQIYIKLVKYAM smg-1_Cele_SMG1 ------------------------CN--------VLKDLNLSNQSTMEKQAFFN------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------TVAN-P-KLWASVSRVF---------SYEEVIVFKDLFHECI ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP TT-------GAGATTTTTTN--TNNT--------IIPPVRIALPSIEESLLFIKLFKSTV ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -------------------N--QN-K-------QF---------HPKETAVFIKLVKHAL CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K -------------------------------------------------------T---- CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 -----------------------------------------------------WEV---- GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP QALDIYQVQ---IAG---NGQTYIRV---------------------------------- SMG1_Hsap_SMG1 DQLENCQT-----CGTDYIISVLNLLTLIVEQINTKL----------------------- FRAP_Hsap_FRAP ----------------------------------AFR----------------------- mei-41_Dmel_ATR ------------------------LS----KDWQ----KLIAILRGFKQLEKLILSQSQH CG2905_Dmel_TRRAP EALDIYTIN---VNP---NQQ----R---------------------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 DQVKRMIS-----LTELQRQSVLYLLLCTVRRLRARL----------------------- FRAP_Mmus_FRAP ----------------------------------AFR----------------------- DNAPK_Mmus_DNAPK ------------------------RTGRWKVPTYKDYVDLFQHLLGCDQ----------- ATR_Mmus_ATR ------------------------PA----STFFSLFLELLQHLVGMDA----------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP MCMDVFVLP---TTR---NQP--------------------------------------- B0261.2_Cele_FRAP ----------------------------------AFP----------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------KEAWSYNLTIGCTSNELVQ----------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------PA----STFFSSFLELLKHLVEMDT----------- DNAPK_Hsap_DNAPK ------------------------RTGKWKVPTYKDYVDLFRHLLSSDQ----------- TOR_Dmel_FRAP ----------------------------------AFN----------------------- SMG1_Mmus_SMG1 DQLENCQT-----CGTDYIISVLNLLTLIVEQINTKL----------------------- TRRAP_Mmus_TRRAP QALDIYQVQ---IAG---NGQTYIRV---------------------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ----------------------------------SFN----------------------- TOR2_Scer_FRAP ----------------------------------AFD----------------------- TRA1_Scer_TRRAP IGLKFFKDHNEKLSPETTKKHFDISM---------------------------------- ATR_Ddis_ATR -----------------------------MANFIYSLLVLFEKLLKLSS----------- DNAPK_Ddis_DNAPK ---------------------------TANTPFYQVYKDLWYNLLNPTI----------- SMG1_Ddis_SMG1 -----------------------IINTILINEFK-------------------------- Tor_Ddis_FRAP ----------------------------------VFC----------------------- TRRAP_Ddis_TRRAP KCFPIYG----------------------------------------------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ----------------------------------AFE----------------------- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP KALDIYQIQ---ISP---TGQTSIRA---------------------------------- CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ----------------------------------AYD----------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ----------------------------------RYTAQGRPVSGYFLICCILEIEWTVL CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------LRPFLVKEFAEAV----------------------- DNAPK_Smoe_DNAPK ---------------------------------YKTYSELLR------------------ FRAP_Smoe_FRAP ----------------------------------HFL----------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ----------------------------------KLD----------------------- GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 PSS--FVEKL-----FIPSSKL-------------------------------------- FRAP_Hsap_FRAP PSA--FTDTQ-----YLQDTMN-------------------------------------- mei-41_Dmel_ATR KIAEHEG----------------------------------------------------- CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 TPS--LVHFI-----FQSNPYM-------------------------------------- FRAP_Mmus_FRAP PSA--FTDTQ-----YLQDTMN-------------------------------------- DNAPK_Mmus_DNAPK ----------MEDFIL----GDETFLFVN---------------SSLKSLN--------- ATR_Mmus_ATR ---DQLK----------------------------------------------------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP QCDRTFQ-TI-----SFD------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ---DQLS----------------------------------------------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ---DQLK----------------------------------------------------- DNAPK_Hsap_DNAPK ----------MMDSIL----ADEAFFSVN---------------SSSESLN--------- TOR_Dmel_FRAP RAV--FV-EK-----YLQTCVS-------------------------------------- SMG1_Mmus_SMG1 PSS--FVEKL-----FIPSSKL-------------------------------------- TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP PQL--FA-GK-----YLHQIMD-------------------------------------- TOR2_Scer_FRAP PAI--FT-KK-----YLDRIMV-------------------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ---NQIP----------------------------------------------------- DNAPK_Ddis_DNAPK ---D--TIDKDLNSTI----KKENNNNNNNKNKNNNNNQTLTKEEISKSIK--------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP SRD--FV-LN-----YFNACMN-------------------------------------- TRRAP_Ddis_TRRAP ---------------------G-------------------------------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP PKM--FV-TS-----YLEDTVK-------------------------------------- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP TQT--FT-EH-----FLHKAMA-------------------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K AQT--MT-EPVVNRATVTEA---------------------------------------- CC1G_00331_Ccin_TRRAP --------------------------------------------------DTLFIEKSRP AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP RDR--FV-TS-----YFTTSMD-------------------------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP PER--FCTTE-----RLQMILT-------------------------------------- GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP -ANCQTV-----------------------------RMKEEKE---------VL-EHFAG SMG1_Hsap_SMG1 ---LFL------------------------------RYHKEKE---------VV-AVAHA FRAP_Hsap_FRAP ---HVLS-----------------------------CVK-KE---------KERTAAFQ- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP -TSGLIS-----------------------------RSKEEKE---------VL-EHFSG CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ---TKV------------------------------RLRSPGE---------TSYKLLLR FRAP_Mmus_FRAP ---HVLS-----------------------------CVK-KE---------KERTAAFQ- DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP -QMHSSM-----------------------------RTKDEKD---------AL-ESLAN B0261.2_Cele_FRAP ---TSFT-----------------------------IL-------------QRNAVAAP- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ---HLMQ-----------------------------ILRGKE---------KDRTVAYI- SMG1_Mmus_SMG1 ---LFL------------------------------RYHKEKE---------VV-AVAHA TRRAP_Mmus_TRRAP -ANCQTV-----------------------------RMKEEKE---------VL-EHFAG smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ---NYLE-----------------------------ILT-NAPANKIPHLKDDKPQILI- TOR2_Scer_FRAP ---HYLR-----------------------------YLK-NIDMNA--ANNSDKPFILV- TRA1_Scer_TRRAP -PSLPVS-----------------------------ATKDARE---------LM-DYLAF ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 --------------------------------------KTDVS---------II-ESNLY Tor_Ddis_FRAP ---HLLA-----------------------------ALR-NQ---------NERPTAFI- TRRAP_Ddis_TRRAP ---CNP------------------------------SPQEEKE---------MI-ENFTA ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ---YMLI-----------------------------SLR-RE---------RERSNAFQ- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -ANTQSV-----------------------------RLKEEKE---------VL-EHFAG CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ---------------------------------------E-------------------- CC1G_00894_Ccin_FRAP ---HLLT-----------------------------QLD-KA---------PERNFAFI- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K --------------------------------------A-------------AANK---- CC1G_00331_Ccin_TRRAP VGGALYA-----------------------------LEKP-------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ---HLLA-----------------------------VMR-NP---------SERSTGFA- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ---FYKK-----------------------------MIP-------------TQQELFI- GK009_Glam_PIKK-Unclassified ------SLCAEASGLAALSSLNVTCYLAVCVHALDYT----------------------- TRRAP_Hsap_TRRAP VFTMMNPL------------------------------TFKEIFQTTVPYMVERIS-KNY SMG1_Hsap_SMG1 VYQA--------------------------------------------------VL-SLK FRAP_Hsap_FRAP ----ALGLLSVA--VRS-EFKVYLPRVLDIIRA--------------------------- mei-41_Dmel_ATR --------------------------------------HIDSS-VLAMLP---------- CG2905_Dmel_TRRAP IFLMMHSQ------------------------------NFQEIFSTTINFLVERIY-KNQ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 TCQE--------------------------------------------------TL-LIR FRAP_Mmus_FRAP ----ALGLLSVA--VRS-EFKVYLPRVLDIIRA--------------------------- DNAPK_Mmus_DNAPK ------HL------------------------------LYDEF-IRSVLKIVEKLD-LTL ATR_Mmus_ATR --------------------------------------LYEEP-LSKLLK---------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP VFTTIDHA------------------------------IFREIFEKYMDFLIERIYNRNY B0261.2_Cele_FRAP ----AIGMMMLS--NPD-VHATHIEKTISFISA--------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM --------------------------------------LFDVM-SSELMN---------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR --------------------------------------LYEEP-LSKLIK---------- DNAPK_Hsap_DNAPK ------HL------------------------------LYDEF-VKSVLKIVEKLD-LTL TOR_Dmel_FRAP ----TIGYMAVA--VQS-AIEVHLSSIMTSVKV--------------------------- SMG1_Mmus_SMG1 VYQA--------------------------------------------------VL-SLK TRRAP_Mmus_TRRAP VFTMMNPL------------------------------TFKEIFQTTVPYMVERIS-KNY smg-1_Cele_SMG1 ----SLAKIVKQLPAE-SQVKTRVHQIVFNTETGLFTPKNRDNRMFGHNMIYKDLI-NLV TOR1_Scer_FRAP ----SIGDIAYE--VGP-DIAPYVKQILDYIEH--------------------------- TOR2_Scer_FRAP ----SIGDIAFE--VGS-SISPYMTLILDNIRE--------------------------- TRA1_Scer_TRRAP MFMQMDNA------------------------------TFNEIIEQELPFVYERML-EDS ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------KL------------------------------VYDEI-VSSILSIIKKLD-LQY SMG1_Ddis_SMG1 LFEC--------------------------------------------------IL-SI- Tor_Ddis_FRAP ----ALGEIAMA--VGG-SIKPYLDSIVVMIKQ--------------------------- TRRAP_Ddis_TRRAP SFMMLDQR------------------------------TFQEVSTFILPFLYQRSL-NNP ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ----AVGLLAVA--VKG-NITEHLGKILEIVRS--------------------------- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP VFNMMHPL------------------------------TFREIFQTTIEYMVERIY-KNY CC1G_00839_Ccin_ATM ------------------------------------------------PDVQSWI-LLNY CC1G_08126_Ccin_ATR ------RR------------------------------LLVESAR--------------- CC1G_00894_Ccin_FRAP ----AIGHTALA--VGS-DMKPFLDPIMDNVRS--------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------ED------------------------------VMLEVWTHKMGFFFEHAQ-KRI AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ---------------------------------------MD------------------- AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ----ALGEMAGA--VGC-ALGEYLPAIMNFIRD--------------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ----PLGEFVIV--IGEKHVKPIFNDLINLITS--------------------------- GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ALQIV------------------------------A-------NSFL-ANPTT------- SMG1_Hsap_SMG1 NIPVL------------------------------ETAYKL---------ILGEMTCALN FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP SLQVI------------------------------A-------NSFL-ANPTT------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 NVPLL------------------------------QQAYKY---------LVDDIDACLE FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK EKQTVGEQE--------DGS-T-ADVWVIPTSDPAA-------NLHP-AKPSD------- ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP PLQLM------------------------------V-------NTFL-VRNE-------- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR --------------------------------------------------ENT------- ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK EIQTVGEQE--------NGD-EAPGVWMIPTSDPAA-------NLHP-AKPKD------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 NIPVL------------------------------ETAYKL---------ILGEMTCALN TRRAP_Mmus_TRRAP ALQIV------------------------------A-------NSFL-ANPTT------- smg-1_Cele_SMG1 SVLLT------------------------------PTSLNHLQATYT-DLRKIM------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP GLLHV------------------------------A-------QSFL-TSEIT------- ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK QKDENDNNSNSNSNNNNNNDQDNNKISIIEYESEIN-------QLKP-VTSKD------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP SLLLI------------------------------P-------QGFL-SVTQMN------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ALQLI------------------------------A-------NSFL-ANLTT------- CC1G_00839_Ccin_ATM AAIAY------------------------------A-------ESHWAGANV-------- CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP VLLTV------------------------------C-------QFLF-NREST------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP --------------SALFATILVEYLLDRLPEMGS-NVE-LSNLYL-------------- SMG1_Hsap_SMG1 NLLHSLQLPEACSEIKHEAFKNHVFNVDNAKFVVI-FDL-SALTTI-------------- FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ----------------------------------------------LQ------------ CG2905_Dmel_TRRAP --------------SPLFATVLVEYLLNKMEEMGS-NLE-RSNLYL-------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 KLLIT----------------APRSKARKASVLLV-FHL-SALAAL-------------- FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK --------------FSAL-INLVEFCREILPRKHV-GF-FEPWVYS-------------- ATR_Mmus_ATR ----------------------------------------------TLFPF--------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP --------------VPFFASTMLSFLMSRMKLLEVS-ND-KTMLYV-------------- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ----------------------------------------------HKLPY--------- MEC1_Scer_ATR --------------MNLYEQALTEVLLGKTELLKF-YDTLK-GLYILLYWFTSEYSTFGN ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ----------------------------------------------TLFPF--------- DNAPK_Hsap_DNAPK --------------FSAF-INLVEFCREILPEKQA-EF-FEPWVYS-------------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 NLLHSLQLPDACSEIKHEAFQNHVFNIDNANFVVI-FDL-SALTTI-------------- TRRAP_Mmus_TRRAP --------------SALFATILVEYLLERLPEMGS-NVE-LSNLYL-------------- smg-1_Cele_SMG1 --------IDSMSRLKQSEDTPYSDNIRWNESILL-LFF-SSLQSI-------------- TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP --------------SPNFAGILLRFLKGKLKDLGNVDFN-TSNVLI-------------- ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK --------------IELF-LGLVEFFKLFISKYNT-EL-FVQWIYI-------------- SMG1_Ddis_SMG1 -------------------------SVSNEPTIVV-PNT-TTATTA-------------- Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP --------PTGVQINRVFLEVLTPFLYEKIRNLQP-TDK-PDICMI-------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP --------------SATFATILVEYLLERMEEMGT-NQE-RSNLYL-------------- CC1G_00839_Ccin_ATM --------------DALISS---------------------------------------- CC1G_08126_Ccin_ATR --------------------RVFDYILSPSCH-FT-N-DRRIRWLG-------------- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP --------------TSILLGIVLKYLVGRLPLLGE-YDDITAAATI-------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ----------------------KLFKLVFGSVSL-------------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR -----------------------------------------CEIIKVADTNWNNLSMQLV CG2905_Dmel_TRRAP ----------------------RLFKLVFGSVSL-------------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ----------------------FAYELILQSTRLPLISG--------------------- ATR_Mmus_ATR ------------------------------------EAEAYRNIEPVYLNVLLEKLSVMF ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ----------------------KLFKIIFSAIGA-------------------------- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------MIGQENYVEEL----RSESLVSLY MEC1_Scer_ATR SIAFLDSSLGFTKFDFNFQRLIRIVLYVFDSCEL-------------------------- ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------EAEAYRNIEPVYLNMLLEKLCVMF DNAPK_Hsap_DNAPK ----------------------FSYELILQSTRLPLISG--------------------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ----------------------KLFKLVFGSVSL-------------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ----------------------RLFKLSFMSVNL-------------------------- ATR_Ddis_ATR -------------------------------------ALLYNNIVGQFFNVLLP-MSMLL DNAPK_Ddis_DNAPK ----------------------FGKEMISFSKKYPLISG--------------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ----------------------KLIKLIFNAIQP-------------------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ----------------------KLFKLVFGSVSL-------------------------- CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ----------------------KLFQVVLETLSD-------------------------- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ----------------------RLFKMAFNAVTT-------------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ----------------------FA------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------GNAKNSLIGMWA FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ELESK--CSADR------------------------------------------------ CG2905_Dmel_TRRAP ----------------------FP------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------AKQTSSIIGMYA FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ----------------FYKLLSIA------------------------------------ ATR_Mmus_ATR EDRVL--MRLKS------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ----------------------NG------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM REYIL--LRLSNYKPQLFTVNH-------------------------------------- MEC1_Scer_ATR ----------------------AA------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR EDGVL--MRLKS------------------------------------------------ DNAPK_Hsap_DNAPK ----------------FYKLLSIT------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------GNAKNSLIGMWA TRRAP_Mmus_TRRAP ----------------------FA------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------SCAKSSLIVMMG TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ----------------------FP------------------------------------ ATR_Ddis_ATR NDKDCSKRRE-------------------------------------------------- DNAPK_Ddis_DNAPK ----------------FYKLVQIV------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------TTATTSNTSTAA Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ----------------------NNNSGVGGSGGSNSSGGGGGGGSNSSNNSTNSNTTTNI ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ----------------------FA------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ----------------------TG------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ----------------------YP------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP -------A--E----------------------NEQMLK--------------------- SMG1_Hsap_SMG1 LSPTVFAL-----------------------------LS--------------------- FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP -------V--E----------------------NEQMLR--------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 CKPSILEL-----------------------------LL--------------------- FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK -------V--KNARKIKYFEG--------------------------------------- ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP -------SGLH----------------------GDKMLTSYLPE-------------ILK B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM -----------------------------------QFEKNDLEK-------------VDN atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR -------L--E----------------------YAEIQL--------------------- ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK -------V--RNAKKIKYFEG--------------------------------------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 LSPTVFAL-----------------------------LS--------------------- TRRAP_Mmus_TRRAP -------A--E----------------------NEQMLK--------------------- smg-1_Cele_SMG1 IRPSIFEF-----------------------------FS--------------------- TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP -------N--I----------------------NEVVLL--------------------- ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK -------M--QICKSQKYFNELQQDDNINSVIFNNQIID--------------------- SMG1_Ddis_SMG1 AATTT------------------------------------------------------- Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP DSTCVQQV-----------------------------LS--------------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -------N--E----------------------NEQMLK--------------------- CC1G_00839_Ccin_ATM ----------------------------------------QAPDVLDAKVWDTILQSVVR CC1G_08126_Ccin_ATR -------P--L----------------------FSYMQE--------------------- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP -------H--T----------------------NESILA--------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP PHLHK------------------IV----NSSME-LAQT--AKEPYNYFL-----LLRAL SMG1_Hsap_SMG1 KNLM--------------------------IVHSDL---AVHFPAIQY-A-----VLYTL FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP PHLHK------------------IV----NRSME-LALI--SEEPYNYFL-----LLRAL CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 TNCR--------------------------AHELKF---WSKYPAAQQ-A-----IFGLL FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK -----------------------IS----PKSLK-HSPE--DTEKYSCFA-----LFAKF ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP Q------------------------------STV-LALT--AREPLNYFL-----LLRAL B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM S------------------------------LNS-AA----------------------- atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------VEFS-YIRG--SRDKNSWFA-----LPDFR MEC1_Scer_ATR KYISL------------------VVDYVCNRTIS-TALD--AP----------------- ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK -----------------------VS----PKSLK-HSPE--DPEKYSCFA-----LFVKF TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 KNLM--------------------------IVHSDL---AVHFPAIQY-A-----VLYTL TRRAP_Mmus_TRRAP PHLHK------------------IV----NSSME-LAQT--AKEPYNYFL-----LLRAL smg-1_Cele_SMG1 SELP--------------------------LTEYWL---ASNHPEVYHL------FITIF TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP PHLND------------------LI----LNSLK-YSTT--AEEPLVYFY-----LIRTL ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK EQLQQQQDIMDIDDTDNNSNSNNKI----NKKLT-NS-L--EEDKNNCFI-----LFKKY SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP SMIL--------------------------ILLK-LITESKQIDSIQYLL-----LLKTI ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP PHLHK------------------IV----NRSME-LATT--AKDPYNYFL-----LLRAL CC1G_00839_Ccin_ATM R------------------------------INT-AAVC--RAASHATHS-----LLISL CC1G_08126_Ccin_ATR RLLHS------------------RY----DGTIH-GNT-----------TTLDVLLNQSF CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP SHLPK------------------LL----MDCFP-LAAK--ASKPTHYFY-----LLRAL AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP FRSI--GGGSH-DLLY-----------------------QEFLPLLP------------- SMG1_Hsap_SMG1 YSHC--TRHDH----FISSS-LSSSSPSLFDGAVISTVTTATKKHFS------------- FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------RHIH-----------------------LEICSLLM------------- CG2905_Dmel_TRRAP FRSI--GGGSH-DLLY-----------------------QEFLPLLP------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 VVHC--QANHN----FRT------NSSLLRDQELSAENTSPTANSFA------------- FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK GKEV-------------------------------------------------------- ATR_Mmus_ATR ------------DLLK-----------------------AALCHLLQ------------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP FRSI--GGGAQ-DILY-----------------------GKFLQLLPN------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM LR--DRGGRSVWLKIL-----------------------GITKSLLT------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------DLLK-----------------------AALCHLLQ------------- DNAPK_Hsap_DNAPK GKEV-------------------------------------------------------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 YSHC--TRHDH----FISSS-LSSSSPSLFDGAVISTVTTATKKHFS------------- TRRAP_Mmus_TRRAP FRSI--GGGSH-DLLY-----------------------QEFLPLLP------------- smg-1_Cele_SMG1 VGHL--KAHDF----YIV------QSDYIVRGDSIGQSIGQTKRDYA------------- TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP FRSI--GGGRF-ENLY-----------------------RSIKPILQ------------- ATR_Ddis_ATR -------------EID-----------------------IKLTSIIP------------- DNAPK_Ddis_DNAPK IKEV-------------------------------------------------------- SMG1_Ddis_SMG1 ------------------TPTLSTSSSS-LSPPAST------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP FKSC--TRPDQ----S-----------------------KEITLLFP------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP FRSI--GGGSH-DLLY-----------------------QEFLPLLP------------- CC1G_00839_Ccin_ATM YR---------------------------------------------YTPPSGHIFLSSP CC1G_08126_Ccin_ATR DR--PFSTASR-AVVY-----------------------QAL----G------------- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP FRAIGVGGGRF-ELLY-----------------------SAVLPLLP------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP N--L---------------L-QG-------------L-NM-LQ-SGLH---KQHMKDLFV SMG1_Hsap_SMG1 I--I---------------L-NL-------------L-GILLK-KDNLNQ---DTRKLLM FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR Q--I-------------------------------------------------------- CG2905_Dmel_TRRAP N--L---------------L-EG-------------L-NR-LQ-SGFH---KQHMRDLFV CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 S--I---------------L-RF-------------LDSVLGQ-AHQLAP---QNLRVLL FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ---------------------------------------------SVK---MKQYKDELL ATR_Mmus_ATR Y--FL-TFVPAG---------------------------YE------S---ALQVRKVYV ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ---L---------------L-QF-------------L-NK-LT-SCQH---RIQMRELFV B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR --------------------------------------------------------DIFQ TEL1_Scer_ATM Y--FALNRKN-------------------------------------------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR Y--FL-KFVPAG---------------------------YE------S---ALQVRKVYV DNAPK_Hsap_DNAPK ---------------------------------------------AVK---MKQYKDELL TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 I--I---------------L-NL-------------L-GILLK-KDNLNQ---DTRKLLM TRRAP_Mmus_TRRAP N--L---------------L-QG-------------L-NM-LQ-SGLH---KQHMKDLFV smg-1_Cele_SMG1 RKQV---------------V-AL-------------Q-KIINNFGDKLW----------- TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP V--L---------------L-QS-------------L-NQ-MI-LTAR---LPHERELYV ATR_Ddis_ATR L--LF-SNVPSSTLFDFSSIILP-------------N-ILFII--NNT---NLTELKVSI DNAPK_Ddis_DNAPK ---------------------------------------------SNF---ISHYKDELL SMG1_Ddis_SMG1 Q--S---------------S-LSLSSSSSAVIAPTTV-GYI------------------- Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP I--I---------------L-ET-------------L-NDLLL-SSSHSTMIPAVQQLLI ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP N--L---------------L-QG-------------L-NQ-LQ-SGLH---KQHMKDLFV CC1G_00839_Ccin_ATM R--V---------------L-QE-------------I-EI-IC-KDIN---IEGPHAPYD CC1G_08126_Ccin_ATR C--LNASPNDERNPQVHTLAISY-------------L-KHSLS--GID---KELL----- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP E--L---------------L-ES-------------L-NR-QL--LAS---EGQTRDMIV AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP -ELCLTVPVRL-S----------------------------------------------- SMG1_Hsap_SMG1 -TWALEAAVLM-K----------------------------------------------- FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP -ELCLTVPVRL-S----------------------------------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 -QWIQM---LLRE----------------------------------------------- FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK -ASCLTFVLSL-P----------------------------------------------- ATR_Mmus_ATR TNIC-RALVDA-L----------------------------------------------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP -ELCLTVPVRL-S----------------------------------------------- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -CFATEIEAHH-S----------------------------------------------- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ---ALVCCEQL-K----------------------------------------------- ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR RNIC-KALLDV-L----------------------------------------------- DNAPK_Hsap_DNAPK -ASCLTFLLSL-P----------------------------------------------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 -TWALEVAVLM-K----------------------------------------------- TRRAP_Mmus_TRRAP -ELCLTVPVRL-S----------------------------------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP -ELCITVPVRL-S----------------------------------------------- ATR_Ddis_ATR LDIY-LNILKL-S----------------------------------------------- DNAPK_Ddis_DNAPK -SSCIELLLSL-P----------------------------------------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP -ELSLSIPVQI-A----------------------------------------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -ELCLTVPVRL-S----------------------------------------------- CC1G_00839_Ccin_ATM -SVCMLLI---------------------------------------------------- CC1G_08126_Ccin_ATR -------PLVL-K----------------------------------------------- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------FPVRY-CDLPASSQITFTVWDIGGPRTAVPVGGSTFRLFGKKWTLRRGKHRLLL CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP -ELCLTVPLRL-T----------------------------------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K WPGVEADGSVETTTPSKLAIRDEMGRLEKLVKKYERGDLPKNDWLDTMAFRKMEEIHAAE CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------DAEGAMEFFGKCSVAMARGLEKGVASLTVRIEVLEWVGEFPKWFRKLEGMTLLS GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ---------------------S------LLPYLPMLMDP-----------LVSALNG-S- SMG1_Hsap_SMG1 ---------------------K------SETYAPLFSLPSFHKFCKG--LLANTLV-ED- FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ---------------------S------LLPYLPMLMDP-----------LVSALNG-S- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ---------------------C------REKIDLLMEQENFRGICRNIAATASKLV---- FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ---------------------HDIIELDVRAYVPALQMA-----------FKLGLSH--- ATR_Mmus_ATR ---------------------G------VQKHVGYLLGP-----------FYAALKM-E- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ---------------------S------LLPYLPLLMDP-----------LVCAMNG-S- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ---------------------L------NNPLWPRILRS-----------LLSVQNP-H- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ---------------------F------VLTTMHHFLDN-----------KYGLLDN-D- ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ---------------------G------IEVDAEYLLGP-----------LYAALKM-E- DNAPK_Hsap_DNAPK ---------------------HNIIELDVRAYVPALQMA-----------FKLGLSY--- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ---------------------K------SETYAPLFSLPSFHKFSKG--LLANTLV-ED- TRRAP_Mmus_TRRAP ---------------------S------LLPYLPMLMDP-----------LVSALNG-S- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ---------------------V------LAPYLPFLMKP-----------LVFALQQ-Y- ATR_Ddis_ATR ---------------------E------LQFKSIYNLVP-----------LFGDEGI-HD DNAPK_Ddis_DNAPK ---------------------KQLIS--IPLLVPIANLA-----------FQYGISY--- SMG1_Ddis_SMG1 ---------------------------------FKFNKELFRKLIAL--VY-STVV--Q- Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ---------------------T------LLPSLHLLVKP-----------LMLALDSSS- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ---------------------S------LLPYLPMLMDP-----------LVSALNG-S- CC1G_00839_Ccin_ATM --------------------------------------------------------E-C- CC1G_08126_Ccin_ATR ---------------------H------LQATLGHAIEP-----------PRTLIKA-T- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K TEKSENLFLYIDLP---------------------------------------------- CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ---------------------H------LLPHLSYLMQP-----------LALALRG-G- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 SSLFVALVAAASDEEHTVRLQA------SKTF---------------------------- GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP -----QT-------------------------------------------LVSQGLRTLE SMG1_Hsap_SMG1 -----VN-------------------------------------------ICLQACSSLH FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP -----PT-------------------------------------------LISQGLRTLE CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------P-------------------------------------------LESAAC---- FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK -----MP-------------------------------------------LAEIGLHALK ATR_Mmus_ATR -----SK-------------------------------------------EIIERIQ--- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP -----PN-------------------------------------------IVTQGLRTLE B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM -----RK-------------------------------------------AVSSGFDAL- atl-1_Cele_ATR ---------------------------------------------------------C-- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR -----PT-------------------------------------------MAKGILRLYS ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR -----SM-------------------------------------------EIIEEIQ--- DNAPK_Hsap_DNAPK -----TP-------------------------------------------LAEVGLNALE TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 -----VN-------------------------------------------ICLQACSSLH TRRAP_Mmus_TRRAP -----QT-------------------------------------------LVSQGLRTLE smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP -----PD-------------------------------------------LVSQGLRTLE ATR_Ddis_ATR KLYQCFDYVINQSYLIDTDDDDDDTDIDISLEILNTLIDYSNCLNISNIYESISTVT--- DNAPK_Ddis_DNAPK -----LP-------------------------------------------LAHVGLNAIE SMG1_Ddis_SMG1 -----HQ-------------------------------------------ITLSTVFTTL Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP -----SE-------------------------------------------LLSTTFRILE ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -----QT-------------------------------------------LVSQGLRTLE CC1G_00839_Ccin_ATM -----LK-------------------------------------------IASQDVRLYR CC1G_08126_Ccin_ATR -----QP-------------------------------------------KPSAGST--- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP -----FE-------------------------------------------LASQGLRTLE AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ---------------------------------------------------------GAL GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP LCVDNLQPD-F------------------------------------------------- SMG1_Hsap_SMG1 ALSSSLPDD-L------------------------------------------------- FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP LCVDNLQPD-F------------------------------------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 --IQTVLDY-G------------------------------------------------- FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK EW-SVHIDKSI------------------------------------------------- ATR_Mmus_ATR ----CQAQQENLS----------------------------------------------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP LCVDNLQPE-Y------------------------------------------------- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM LCIS-------------------------------------------------------- atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR LCISNDFSK-C------------------------------------------------- ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ----CQTQQENLS----------------------------------------------- DNAPK_Hsap_DNAPK EW-SIYIDRHV------------------------------------------------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ALSSSLPDD-L------------------------------------------------- TRRAP_Mmus_TRRAP LCVDNLQPD-F------------------------------------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP LCIDNLTAE-Y------------------------------------------------- ATR_Ddis_ATR ----NSVKDKNIDNNTENIEKDDGDGGAGGTSENVNNKQIENQKSITEDSKQQQQQQQQQ DNAPK_Ddis_DNAPK YW-NLVVPD-Q------------------------------------------------- SMG1_Ddis_SMG1 VLKGYLNED-Q------------------------------------------------- Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP LIVDNATGD-F------------------------------------------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP LCVDNLQPD-F------------------------------------------------- CC1G_00839_Ccin_ATM LHMEDKV----------------------------------------------------- CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP LCIDNLTPD-F------------------------------------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 LRHKCLSSS-Q------------------------------------------------- GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP --LYDH-IQP---VRAELMQAL-------------------------------------- SMG1_Hsap_SMG1 --LQRC-VDV---CRVQLVHSG-------------------------------------- FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP --LYDH-IQP---VRAALMQAL-------------------------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 --LERL-EK--------------------------------------------------- FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK --LQPY-YKD---ILPCLDGYLNTSTLSDETKSHWGLSALSRAAQKG------------- ATR_Mmus_ATR -GNNDE-VSP---KRRKLSSSLS-----------------------SYKKPSRQPEEIIH ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP --LLEN-MLP---VRGALMQGL-------------------------------------- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ---QQF-CKKFVPSI----DKL-------------------------------------- TEL1_Scer_ATM ---ENYSLLF---KRRKCDSDIP-----------------------SILRISD------- MEC1_Scer_ATR --FVDH-F-P---ID--------------------------------------------- ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR -SNSDG-ISP---KRRRLSSSLN-----------------------PSKRAPKQTEEIKH DNAPK_Hsap_DNAPK --MQPY-YKD---ILPCLDGYLKTSALSDETKNNWEVSALSRAAQKG------------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 --LQRC-VDV---CRVQLVHSG-------------------------------------- TRRAP_Mmus_TRRAP --LYDH-IQP---VRAELMQAL-------------------------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP --FDPI-IEP---VIDDVSKAL-------------------------------------- ATR_Ddis_ATR PTIEQ------------------------------------------------------- DNAPK_Ddis_DNAPK --VHKH-LDQ---LLPSLNDYLKISTNSSDSTSGGDIDIDSGGSMGGGGVVPPPSSSSRH SMG1_Ddis_SMG1 --IQKL-LNI---TLFKLSDPS-------------------------------------- Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP --LLFT-FRD---NKSEFLQIL-------------------------------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP --LYEH-IQP---VRAELMQAL-------------------------------------- CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ---------Q---ARMNLKDHV-------------------------------------- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K -------------RFDFPVIFC-------------------------------------- CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP --LDPT-LSV---VLRELMEAL-------------------------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK -----------------------------------------------NADSVPPS----- FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 --LYSV-ASA---AFEQLGDPD-------------------------------------- GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ---------WRTL----R------------------------------------------ SMG1_Hsap_SMG1 ---------TRIR----QAFGKL------LKSIP--LDVVLSNNNHTEIQEI-------- FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ---------WKTL----R------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ----------------------YPKLLILYRDTALQQLQMLSTNYHAPYFQI-------- FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK FN----RHVVKHLKRTRN------------------------------------------ ATR_Mmus_ATR VDMDKKSILWNVL----K------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ---------WRVV----S------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ---------WITL----L------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR VDMNQKSILWSAL----K------------------------------------------ DNAPK_Hsap_DNAPK FN----KVVLKHLKKTKN------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ---------TRIR----QAFGKL------LKSIP--LDVVLSNNNHTEIQEI-------- TRRAP_Mmus_TRRAP ---------WRTL----R------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ---------FNLL----Q------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK R--------------KMK------------------------------------------ SMG1_Ddis_SMG1 ---------EQVK----LSYLTL------LSKMVSYFDLNHQKNLNHKVNDI-------- Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ---------SKHL----------------------------------------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ---------WRTL----R------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ---------W-------------------------------------------------- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ---------EPEP----VASTS-----------------------------AAATTTTTT CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ---------FSHL----K------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ---------PGIQ----AAFRE-----------------------------VLATCALGA GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ---------WRSL----K------------------------------------------ TRRAP_Hsap_TRRAP ------------N----------------------------------------------- SMG1_Hsap_SMG1 ----------SL------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------N----------------------------------------------- CG6535_Dmel_ATM ------------N----------------------------------------------- CG4549_Dmel_SMG1 ----------YA------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------S----------------------------------------------- ATR_Mmus_ATR ------------Q----------------------------------------------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------K----------------------------------------------- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------N----------------------------------------------- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------Q----------------------------------------------- DNAPK_Hsap_DNAPK ------------L----------------------------------------------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ----------SL------------------------------------------------ TRRAP_Mmus_TRRAP ------------N----------------------------------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------P----------------------------------------------- ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------F----------------------------------------------- SMG1_Ddis_SMG1 ----------SL------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP -----------RP----------------------------------------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------N----------------------------------------------- CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K LTTVTQA----------------------------------------------------- CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------P----------------------------------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 LWVHGWNSDLDA------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------SDPSPVPSAVSQNNTHVTDIIAHITHASKHHSKHLHLMLRDARMDTSQ TRRAP_Hsap_TRRAP ------------------------PADS--ISHVAYRV---------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------Q-DN--AALVAFRV---------------------- CG6535_Dmel_ATM ------------------------Q----------------------------------- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ----------SPD----------EALSLEEIRIKVVQI---------------------- ATR_Mmus_ATR --------------------------KAESL----------------------------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------APDT-SSMTAAFRI---------------------- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------GESSR--------ATLNSLVIVTASCPFANNNDEGV TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR --------------------------KAESL----------------------------- DNAPK_Hsap_DNAPK ----------SSN----------EAISLEEIRIRVVQM---------------------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------PADS--ISHVAYRV---------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------QPFNHAISHNVVRI---------------------- ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ----------KSNSSLIDPKQLQFKTSIEDLQNRIIRL---------------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------APYF--YGPHAIRI---------------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------RSDQ--IARVAFRV---------------------- CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------APQSHHLAHTTIRI---------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified HALLRQAVNAYCRLMQVLTEFLSNPVG--------------------------------- TRRAP_Hsap_TRRAP -----------------------------------------LGKFGGSNRKMLKESQKL- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP -----------------------------------------LGKFGGGNRKMMVEPQAL- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK -----------------------------------------LGSLGGQINKSLVTATS-G ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP -----------------------------------------LGKFGGANRKLLNQPQIL- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR KQIIPFLLIPCFQDFRDRVGSKWDNFRFIGLPKSEPSELINLERFTTVL----------- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR -----------------------------------------------------------Q ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK -----------------------------------------LGSLGGQINKNLLTVTSSD TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP -----------------------------------------LGKFGGSNRKMLKESQKL- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP -----------------------------------------LGKLGGRNRQFLKPPTDL- ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK -----------------------------------------LGQLGGDNVHFLGKVSLVG SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP -----------------------------------------LGKMAGKSRSFSVLSPIL- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -----------------------------------------LGKLGGGNRKMLREPQRL- CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP -----------------------------------------LGKLGGRNRRLLFKEPALI AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------HYVV-TEVQG----------------PSIT------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------SYII-NDKPT----------------ISIV------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK --------ERMKKYVAWDAERR----------------LSFA------------------ ATR_Mmus_ATR ---------------------------------------QI------------------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------QVAT-LG--D----------------SYINM----------------- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR WADFSQSEH----FP--FTQL-----------------TNKA------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ---------------------------------------QI------------------- DNAPK_Hsap_DNAPK --------EMMKSYVAWDREKR----------------LSFA------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------HYVV-TEVQG----------------PSIT------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------TE-K-TELDI----------------DA-I------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK --------EEIVNGVAWDTEPK----------------VLIK------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------SIDS-TS-NS----------------RSIPSSNKNNNNNNYYYNGSCS ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------TYED-DENDG----------------PCIT------------------ CC1G_00839_Ccin_ATM ---------------------LEWLKNSWVITGYEKTAGPHPV----------------- CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP --------Y----HH--PSEP-----------------AKMV------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified --------------------------------------TSAVLMDELCSELLSVRLLHTI TRRAP_Hsap_TRRAP ------------VEFS----D---CKAS--L----------------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP -----------AL----------------------------------------------- mei-41_Dmel_ATR -------------TFI----RHFLK-----TQTQHQLLAILQRHLKLSYLCA-------- CG2905_Dmel_TRRAP ------------TYFQ----E---YETP--I----------------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP -----------AL----------------------------------------------- DNAPK_Mmus_DNAPK ------------VPFR----E---MKPV--IYL--------------------------- ATR_Mmus_ATR -------------SLE----CGTLK-----NSVAE-ALEGITVVLQLTALCTVHCSHQDM ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP -------------EFSRMGLD---GNHS--I----------------------------- B0261.2_Cele_FRAP -----------AI----------------------------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM -------------------------------DMDTF------------------------ MEC1_Scer_ATR ------------LSIV----Y---FDL--KRRS--------------------------- ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR -------------SLE----YSGLK-----NPVIE-MLEGIAVVLQLTALCTVHCSHQNM DNAPK_Hsap_DNAPK ------------VPFR----E---MKPV--IFL--------------------------- TOR_Dmel_FRAP -----------AL----------------------------------------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------VEFS----D---CKAS--L----------------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP -----------DL----------------------------------------------- TOR2_Scer_FRAP -----------GL----------------------------------------------- TRA1_Scer_TRRAP ------------ADFK----I---NGMPEDV----------------------------- ATR_Ddis_ATR -------------------------------------QKSIRIYLKALHLIFKICK---- DNAPK_Ddis_DNAPK ------------IPFA----D---QNNI-DIYL--------------------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP -----------GL----------------------------------------------- TRRAP_Ddis_TRRAP NSENYSKVFKLLL----------------------------------------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP -----------SL----------------------------------------------- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------ILFP----D---HKTP--V----------------------------- CC1G_00839_Ccin_ATM -------------NDLILLLA---TICG--I----------------------------- CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP -----------CL----------------------------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ----------PTL----------------------------------------------- CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------ISFN----G---NEE--KILL--------------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -----------AV----------------------------------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP -----------SF----------------------------------------------- GK009_Glam_PIKK-Unclassified LSGIQLLYVLHCL----------------------------------------------- TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR DGHNVKDHQHKYKKKPPVV----------------------------------------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------LIHLLEENSSHEFEVLGLQLCSFYGTLQDFTKSFAEQLKELL MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR NCRTFKDCQHKSKKKPSVV----------------------------------------- DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------NHHNRVSVKELVN----------------------------------------- DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP PPKD---------------FAHKRQKAMQVDATVFTCISMLARAMGP------------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP PPKD---------------FAHKRQKTVQVDATVFTCISMLARAMGP------------- DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR -------------------------------------VTWMS------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP K----------------------KTTNSDVLDNYFTFLFLFVDAYHE------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM FSK--------------------FEK--------IQCFNWVCFSFIP------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR -------------------------------------ITWMS------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP PSKD---------------LT--SKRKVPVDPAVFACITLLAHAVKS------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP QTKF--------------------KFRKKFENEIFYCIGRLAVPLGP------------- TOR2_Scer_FRAP RTKF--------------------KVRKQFEKDLFYCIGKLACALGP------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR -------------------------------------L---------------------- DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP MTK--------------------G---KQFCPEVLTCISMLASAVGQ------------- TRRAP_Ddis_TRRAP PC-E---------------TGDDKTKSIPLDKSIQSIKNILLYQL--------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP PHKD---------------IPHRKHKSIIVDPAVFTCISMLARAVGP------------- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP QNR--------------------GRKNAPSEEPIFQCIGMLAAAVGP------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K PSNS---------------ALLAR------------------------------------ CC1G_13883_Ccin_PI4K --------------------------------------AWLALSRNPALELQVDDNTKST CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP LYFSSVGFYILILYFFVCQLQ--PRRGKP-SMEAIACVGNLTEALGP------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP KSQN---------------FT---KAGSILPPEPLKCIQYITKGAPN------------- GK009_Glam_PIKK-Unclassified --------------------EDK--SSAPIPVNSEECYTQ-------------------- TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ----------------------------------------------------GI------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ----------------------------------------------------GI------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ----------------------------------------------------QV------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ----------------------------------------------------LLSQKECE MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ----------------------------------------------------EI------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ----------------------------------------------------VL------ TOR2_Scer_FRAP ----------------------------------------------------AF------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ----------------------------------------------------SM------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ----------------------------------------------------VI------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ----------------------------------------------------NL------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K LRAGVAYSMQCFTDLLVQIEAMRVDPSIDIYAWETMAESLKLASVCCIALRELD------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ----------------------------------------------------LM------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ----------------------------------------------------LV------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------QLPMEKA----------------------------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------QQDI-K------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------DFPVDEA----------------------------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------QQDI-K------------------------------------------------ DNAPK_Mmus_DNAPK ------------DVFLPRV----------------------------------------- ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------HLPLSEL----------------------------------------- B0261.2_Cele_FRAP ------TTQI-K------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ----------------ERSTSESTKLRAVNCALQLEKKTGKYINLVAEMSLAVFSKSQTD TEL1_Scer_ATM LSNGDMARLFKVCLPLVKS----------------------------------------- MEC1_Scer_ATR ----------------LPV----------------------------------------- ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------DVFLPRV----------------------------------------- TOR_Dmel_FRAP ------ADDV-K------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------QLPMEKA----------------------------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------GKLLNR------------------------------------------------ TOR2_Scer_FRAP ------AKHLNK------------------------------------------------ TRA1_Scer_TRRAP ------------PLSVTPG----------------------------------------- ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------DVILPNV----------------------------------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------YPHM-Q------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------ARDV-K------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------HLPVSKV----------------------------------------- CC1G_00839_Ccin_ATM ------------SKPIGLV----------------------------------------- CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------TKLL-H------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------EHLH-S------------------------------------------------ CC1G_00331_Ccin_TRRAP ----------------GPI----------------------------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------EEHV-R------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------QKHV-T------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------ELL-EPM-LAVG mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------ELL-EPM-LAVG DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------AII-PQL-MDIT atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR RIANSFEPLILFLTDNLQLINDFITILIAKLCEKQEFYSELTILKYFKTLQKLFCLAAN- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------DIL-EQM-FYTG SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------NIL-DLM-FKCP TOR2_Scer_FRAP ------------------------------------------------DLL-NLM-LNCP TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------VIL-PQMIVSSG TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------ELL-EPM-LAVG SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------DQL-DLM-LACG CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------RILLLLS-NTSP CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------STL-DIM-FDTG SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------SIL-ECI-FSVG GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP LSPALTAV-----LYDLSRQIPQLKKDIQDGLLKMLSLVLMH------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP LSPALTAV-----LYDLSRQIPQLKKDIQDGLLKMLSLVLMH------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP LSRSLANV-----LKMIMMRIPKLRLNVQDGVMASVYQTLTG------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -----------------------------------------GRNSCKKCGEECFVDPDSK TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP LSPALTVC-----LRELSENVPQLKSAITEGLIGILSQVLMN------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP LSDYMQET-----FQILTERIPSLGPKINDELLNLVCSTLSG------------------ TOR2_Scer_FRAP MSDHMQET-----LMILNEKIPSLESTVNSRILNLLSISLSG------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP LTVVLTDA-----LRDLTINLPTLIPNIQYKLLNLISQVLAN------------------ TRRAP_Ddis_TRRAP -----------------------------------------D------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP LSPALTAA-----LHDLAKQIPQLKKDIQDGLLKMLSLVLMH------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP LSEPLSQA-----LAAIAKYIPPLLKTIQDRLLQLLSMLLSG------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ISDNLVQEAALKSTTVLVRSFPAIAADMTTQLRKFVTS---------------------- CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP LTPTLEKA-----LNQIVTSLPSFLPPIQERLLDFISLVLCK------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP LCESLTSA-----LQDLSANLHNRLLDIQGLLLYLVANELGG------------------ GK009_Glam_PIKK-Unclassified --------------------------DS-------------------------------- TRRAP_Hsap_TRRAP ------------------------------------------------------IETALD SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------IKSAFR CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------TELALS ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------MRVVAD B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ENVKIDYESLSGLIKGIVARRNTFSQELIREFLQTSRVMLLHVDSKGIASSFTSIIKALD TEL1_Scer_ATM ------------------------------------------------------NESCQL MEC1_Scer_ATR ------------------------------------------------------E----- ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------TELALT TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------IETALD smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------IQ---- ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------VNLAEK SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------IETALS CC1G_00839_Ccin_ATM ------------------------------------------------------IRTSLP CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------CKLAIT AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP -CLK---------SA--NTEPYYRRQAWEVIKCFLVAMMSLED----NKHAL-YQLLAHP SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP -------------------K---------------------------------------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP -ALG---------SN--STDQFYRRQSWEVIRCFLAAFISLDD----EKHML-LKLFTHV CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP -------------------K---------------------------------------- DNAPK_Mmus_DNAPK -----------------ASDRQTKVAACELLHSMVMFMLGRAT----QMPEG-QGLPPMY ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP -QMRYPADMILNPSPAMIPSTHMKKWCMELSKAVLLAGLGSSGSPITPSANL-PKIIKKL B0261.2_Cele_FRAP -------------------S---------------------------------------- atm-1_Cele_ATM -----------------------------------------------------------Q atl-1_Cele_ATR -IGF---------SE--NANAYFR--VWELVCCR-------------------------- TEL1_Scer_ATM SCLL---------LA--NSIKFSKQLLSDEKTINQIYDL--------------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK -----------------ASDRQTKVAACELLHSMVMFMLGKAT----QMPEGGQGAPPMY TOR_Dmel_FRAP -------------------K---------------------------------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP -CLK---------SA--NTEPYYRRQAWEVIRCFLVAMMSLED----NKHAL-YQLLAHP smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP -------------------T---------------------------------------- TOR2_Scer_FRAP -------------------E---------------------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK -----------------SPNRQIKVAAGELLHSVLLMMIGNSA----NQSQA-NQ-ISYS SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP -------------------K---------------------------------------- TRRAP_Ddis_TRRAP -------------------DSYLQSNAYSLLKYYISLYLSSQDFLINQQSLL-NELLNNL ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP -------------------K---------------------------------------- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -KLT---------SP--TTDVFYRRQAWEVIRHFIVSMLSLGD----EQRTI-QQLLFHT CC1G_00839_Ccin_ATM -S--CP------------------------------------------------------ CC1G_08126_Ccin_ATR -----------------------RRQVQELVQA--------------------------- CC1G_00894_Ccin_FRAP -------------------Q---------------------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP T------------LA--KSPPADQMHAYSFLENCASLFLYEG-----------IKGRNVE AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -------------------A---------------------------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP -------------------I---------------------------------------- GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP N--------------------------------------------------------FTE SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP --------------------------------------------------------PL-- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP D--------------------------------------------------------FVE CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP --------------------------------------------------------PL-- DNAPK_Mmus_DNAPK Q--------------------------------------------------------LYK ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ----------------------------------------------------------LE B0261.2_Cele_FRAP --------------------------------------------------------LI-- atm-1_Cele_ATM ----------------------------------------------------------LE atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK Q--------------------------------------------------------LYK TOR_Dmel_FRAP --------------------------------------------------------AA-- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP N--------------------------------------------------------FTE smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP --------------------------------------------------------PF-- TOR2_Scer_FRAP --------------------------------------------------------KF-- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK R--------------------------------------------------------LYR SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP --------------------------------------------------------PF-- TRRAP_Ddis_TRRAP KQSNNNNNNNSSTVNLNIIELDNENENENDNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP --------------------------------------------------------PL-- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP S--------------------------------------------------------FHD CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP --------------------------------------------------------PY-- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP D--------------------------------------------------------FFV AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP --------------------------------------------------------PY-- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP --------------------------------------------------------NLFL GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP KTIPNVIISHRYKAQDTPARKTFEQALTGAFMSAVIK-----------D-LR-------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ---------------------------------------------------R-------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP NKIMNW-STFQHKAGNETVRETHQTALIGMLVASATK-----------D-LR-------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ---------------------------------------------------R-------- DNAPK_Mmus_DNAPK H---------------------------------TFPVLLQLACDVDQV-TRQ------- ATR_Mmus_ATR ----------------------------LDFYTKVLK-----------S-CRSLLESVQ- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP DFDPNNRTTEVYTCPRESDRELFVNALLAMAYGIWNK-----------DGFR-------- B0261.2_Cele_FRAP ---------------------------------------------------P-------- atm-1_Cele_ATM DDDEAIRASS-------------------------------------------------- atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ---------YELSDILGPILVTNESFMLWGYLQYVGK-----------D-FQSM-NGISS MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ----------------------------LDFYTKVLK-----------S-CRSLLESVQ- DNAPK_Hsap_DNAPK R---------------------------------TFPVLLRLACDVDQV-TRQ------- TOR_Dmel_FRAP ---------------------------------------------------I-------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP KTIPNVIISHRYKAQDTPARKTFEQALTGAFMSAVIK-----------D-LR-------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ---------------------------------------------------I-------- TOR2_Scer_FRAP ---------------------------------------------------I-------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK K---------------------------------IFPSLICLSTDVEQV-TKQ------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ---------------------------------------------------S-------- TRRAP_Ddis_TRRAP NNNNNNIKTFKTKEEYLNEIKNFKDLVYCLFLSITND-----------H-LK-------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ---------------------------------------------------R-------- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP GEIPRT-TSHAYKCHDHLSRICFQNALTSMIVSATIK-----------D-LR-------- CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ---------------------------------------------------R-------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP RTVEGIFDSI------------------------YIPT---IQ--------NEA------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ---------------------------------------------------F-------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP SNAYGVIDGSEDYYLVLTENQSQAVADGHDSGVLDSQ-----------T-SI-------- GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ----------------------KLELELVIDSM--------------------------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ADRIFEWLKSKWNQLRGTDAKQD--------QFCNFISWLGNKYDPENPFNDKKGEGANP MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ----------------------KLDLEATIDKV--------------------------- DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------P--SAL SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------D--SVC CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ---------------------------------------------------------LYE ATR_Mmus_ATR --------VRICDALMYMQVKSS-----------------------FKDH---------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------H--VYS B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM VSLCWDESHKIWQ---------HFQEQREFLLGVKPEEKSECFNTPFFNL---------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR --------VKIYDALIYMQVNSS-----------------------FEDH---------- DNAPK_Hsap_DNAPK ---------------------------------------------------------LYE TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------P--SAL smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ---------------------------------------------------------LFQ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------EKFDSL ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------P--SSL CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR --------------------------------------------------IISPD--SIT CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP -----------------------------------------------ESYLR--K--LAS AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP PFVASLIRHYTMVAVAQQCGPFLLPCYQVGSQPSTAMF---------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP --------H-------------------PGMPKG-------------------LAH---- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP PVMAAVVRHYTMVAIAQQAGPFPQ-------------K---------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP --------H-------------------PGMPKG-------------------LAH---- DNAPK_Mmus_DNAPK PLVMQLIHWLTN------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP KFFIKVLRQFALIGVLEYIGGNGW------------MR---------------------- B0261.2_Cele_FRAP --------P-------------------KSEP---------------------IGR---- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK PLVMQLIHWFTN------------------------------------------------ TOR_Dmel_FRAP --------L-------------------PYTAL--------------------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP PFVASLIRHYTMVAVAQQCGPFLLPCYQVGSQPSTAMF---------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP --------Q-------------------PGSPME-------------------IPSFSRE TOR2_Scer_FRAP --------Q-------------------SNQYDF-------------------NNQFSIE TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK PLVFQMIHWFTR------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP --------E-------------------PGAPSP-------------------YRK---- TRRAP_Ddis_TRRAP KFLNNFIYH-------------------FVLYLSTF------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP --------H-------------------PGTPRA-------------------LLS---- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP PFMMNVVRHITLVAVAQQAGPLPT-------------A---------------------- CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR WMDDDFRPN--------------------------------------------------- CC1G_00894_Ccin_FRAP --------P-------------------LGAPAP-------------------LGR---- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP TVFENEIRRNQS------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP --------S-------------------QRKSLL-------------------V------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP --------I-------------------PGTRPSTTQATTHVEDTRTNEDAIELAH---- GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP -------------------------------------------------HSE-ENGS--- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ---QLASPGL-------------------------------------------TTLP--- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP -------------------------------------------------G---YQAT--- CG6535_Dmel_ATM ----LI------------------------------------------S-ETTTNSE--- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ---QLASPGL-------------------------------------------TTLP--- DNAPK_Mmus_DNAPK -------------------------------------------------NK-KFESQ--- ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP -------------------------------------------------HAE-EEGV--- B0261.2_Cele_FRAP ---PASPKAI--------------------------------------LQK---AET--- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK -------------------------------------------------NK-KFESQ--- TOR_Dmel_FRAP ---PT--IAI--------------------------------------DGS--L--M--- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP -------------------------------------------------HSE-ENGS--- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP RAREWRNKNI--------------------------------------LQKTGESND--- TOR2_Scer_FRAP KARKSRNQSF--------------------------------------MKKTGESND--- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK -------------------------------------------------NK-KQESD--- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP SATPFQGGSI--------------------------------------P---QLGQN--- TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ---PTGQTGT------------------------------------------ALSSI--- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -------------------------------------------------HSRQKSLN--- CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP NEFPAPPNQL--------------------------------------TAT--QMTT--- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP -------------------------------------------------RE-VGARP--- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -RLPQ--KA---------------------------------------VG---LPSS--- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ---DLSITGLKEESEQCDFKNSLSVYQTVTTSAGITALYKLSDRIATALGTSKLRPR--- GK009_Glam_PIKK-Unclassified --------------------------------------------------------SSIS TRRAP_Hsap_TRRAP --------------------------------------K--GMD---------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP --------------------------------------E--ASD---------------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP --------------------------------------H--GID---------------- CG6535_Dmel_ATM --------------------------------------E--IKEKQLVLQMLIRHNKL-- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP --------------------------------------E--ASD---------------- DNAPK_Mmus_DNAPK --------------------------------------DT-VAL---------------- ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM --------------------------------------------NFGLLEAIIQGSLVEL C47D12.1_Cele_TRRAP --------------------------------------LPLCLD---------------- B0261.2_Cele_FRAP --------------------------------------D--PKE---------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM --------------------------------------------NFGLLGAIIQGSLVEV ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK --------------------------------------DT-VAL---------------- TOR_Dmel_FRAP --------------------------------------Q--NGD---------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP --------------------------------------K--GMD---------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP --------------------------------------D--NND---------------- TOR2_Scer_FRAP --------------------------------------D--ITD---------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK --------------------------------------DT-MNL---------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP --------------------------------------S--DVD---------------- TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM --------------------------------------------GFDLLTSLVHHGIVKP ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP --------------------------------------D--SGD---------------- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP --------------------------------------D--NMD---------------- CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP --------------------------------------T--DKN---------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP --------------------------------------TP-SPV---------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP --------------------------------------E--IQG---------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP --------------------------------------R--HST---------------- GK009_Glam_PIKK-Unclassified ETYTMVPLATQLLLLLFRRHLHLSNMVGLQQHESSMTSKL-FAS---------------- TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------NQKLSSTLLNNIISNEMLKRNECLATIREIFIHADKCGQDKA------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM DREFWKLFTGSACK----------------PSSPSVCCLTLALSICVVPD--AIKMGTEQ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM DREFWKLFTGSACR----------------PSCPAVCCLTLALTTSIVPG--TVKMGIEQ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM DKEVWKLFLPDVTQ----------------PSRCSVTFLLTLLTSHPIPENHVCQVGLLA ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ---------SADLEPIIAWAYGSADRFIAAQMIHN------------------------- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM SVCEANR-SFSVKESIMRWLL-----------FYQLEDDLEDSTELPPILQRNFPHLVVE C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM NMCEVNR-SFSLKESIMKWLL-----------FYQLEGDLENSTEVPPILHSNFPHLVLE ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM SLTGVQRGQYPLRHQLLNWIL-----------PAEEVEDAGERLAVTPLILKSVPRDLLA ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ----------IDSIDAQLQADTFAISIINFLDVQQLRQISQSEHIVPST--ERNLLAYKY CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM KILVSLTMKNSKAAMK--FFQSVPECEQHCEDKEEPSFSEVEELFLQTTFDKMDFLTTVK C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM KILVSLTMKNCKAAMN--FFQSVPECEHHQKDKEELSFSEVEELFLQTTFDKMDFLTIVR ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM SLLTTLFTKNCRGQQLGIAFAARPNPE-----NGSSRLSFIEELYLRASF--HIPL--TK ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP -----------------------------------------------------------P SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP -----------------------------------------------------------V mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP -----------------------------------------------------------P CG6535_Dmel_ATM NEQL-------------------------------------------------------- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP -----------------------------------------------------------V DNAPK_Mmus_DNAPK -----------------------------------------------------------L ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM EYAVE--KFQSSVGFS--------VQQNLKESLDHYLLGLSEQLLSNYSSE-ITSSETLV C47D12.1_Cele_TRRAP -----------------------------------------------------------S B0261.2_Cele_FRAP -----------------------------------------------------------L atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ECGIE--KHQSSIGFS--------VHQNLKESLDRCLLGLSEQLLNNYSSE-ITNSETLV ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK -----------------------------------------------------------L TOR_Dmel_FRAP -----------------------------------------------------------G SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP -----------------------------------------------------------P smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP -----------------------------------------------------------I TOR2_Scer_FRAP -----------------------------------------------------------A TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK -----------------------------------------------------------L SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP -----------------------------------------------------------P TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM DSQVNAVEHDTARAFSTEGAVIMMVVQSVSERLGH-------------VVKLVTD----S ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP -----------------------------------------------------------L SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -----------------------------------------------------------P CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP -----------------------------------------------------------S CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP -----------------------------------------------------------L AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -----------------------------------------------------------P SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP -----------------------------------------------------------S GK009_Glam_PIKK-Unclassified -----------------------------------------------------------C TRRAP_Hsap_TRRAP LVL--------------------------------------------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP GSITLALRTLGSFEFEGHSLTQFVRHCADH------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP MIL--------------------------------------------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ASITLALRTLGSFEFEGHSLTQFVRHCADH------------------------------ DNAPK_Mmus_DNAPK EAI--------------------------------------------------------- ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM RCSSLLVGVLGCYCYMGI------------------------------------------ C47D12.1_Cele_TRRAP SVM--------------------------------------------------------- B0261.2_Cele_FRAP QRIVLAVDVLGEFYFSRGALQRIMQYVADY------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM RCSRLLVGVLGCYCYMGV------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK EAI--------------------------------------------------------- TOR_Dmel_FRAP ATTVLALKTLGTFNFEEQNMLDFVQRCADY------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP LVL--------------------------------------------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP KIIIQAFRMLKNIK-SRFSLVEFVRIVALS------------------------------ TOR2_Scer_FRAP QILIQCFKMLQLIH-HQYSLTEFVRLITIS------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK NAI--------------------------------------------------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP QMIALALKTLGSFDFSKHNLLEFVRECVVN------------------------------ TRRAP_Ddis_TRRAP -----------------------KFNYSII------------------------------ ATMa_Spur_ATM QC---------------------------------------------------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP TSTVLALRTLGNFDFEGHSLTQFVRHCADH------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP HVL--------------------------------------------------------- CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ELITLALKTLGTFDFSGHVLNEFVRSCALP------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K --------PLPLFEFEF------------------------------------------- CC1G_00331_Ccin_TRRAP NSF--------------------------------------------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ALVQLALKILTNFNFKGHDLLEFAREAVVM------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP EAILLAFQALYDFDFSLFDLTIFAADYLTR------------------------------ GK009_Glam_PIKK-Unclassified FAFLFSLDTIFSASHDGYMVI--------DFSEEHKDLLRSFLPATATEEFLISLLPFAI TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ----------------------FL----------------------------------NS mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ----------------------FL----------------------------------NS DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM -----------------------ITEDEAHKSELFQKAKSLMQCAGESISL-----FKNK C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ----------------------YL----------------------------------TA atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM -----------------------IAEEEAYKSELFQKAKSLMQCAGESITL-----FKNK ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ----------------------FI----------------------------------VH SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ----------------------YI----------------------------------EH TOR2_Scer_FRAP ----------------------YI----------------------------------EH TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ----------------------YL----------------------------------DD TRRAP_Ddis_TRRAP ----------------------SM----------------------------------KE ATMa_Spur_ATM -------------------------------KEVL---LKRFALGFK---VLEIQSDLTP ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ----------------------FL----------------------------------SS SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ----------------------YL----------------------------------ED CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K -----------------------A----------------------------------SE CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ----------------------HL----------------------------------ED SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ----------------------YL----------------------------------RN GK009_Glam_PIKK-Unclassified ASFIPGASVPSDFVSLYLKQISQL----------------------------------YD TRRAP_Hsap_TRRAP -------------IDA-----------------------------------------IAI SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP EHKEIRM------EAA-----------------------------------------RTC mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP -------------IDA-----------------------------------------LAS CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP EHKEIRM------EAA-----------------------------------------RTC DNAPK_Mmus_DNAPK -------------LDG-----------------------------------------IVD ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM TNEESRI------GSL-----------------------------------------RNV C47D12.1_Cele_TRRAP -------------VDA-----------------------------------------LII B0261.2_Cele_FRAP DNVEIRL------AAV-----------------------------------------SSC atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM TNEEFRI------GSL-----------------------------------------RNM ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK -------------LDG-----------------------------------------IVD TOR_Dmel_FRAP EQQEIRL------EAV-----------------------------------------QTC SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP -------------IDA-----------------------------------------IAI smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP TDPRVRK------LAA-----------------------------------------LTS TOR2_Scer_FRAP EDSSVRK------LAA-----------------------------------------LTS TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK -------------VDA-----------------------------------------VGN SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP DNIEIRR------EAA-----------------------------------------ITC TRRAP_Ddis_TRRAP LDPKIF-------LEA-----------------------------------------LVD ATMa_Spur_ATM DSSISRA------HSL-----------------------------------------KSL ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP EHKEIRI------EA--------------------------------------------- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -------------IDA-----------------------------------------ISA CC1G_00839_Ccin_ATM ---------------I-----------------------------------------VTA CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP DNPQVRC------AAA-----------------------------------------ETC CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K TRAPPPL------AAA-----------------------------------------AKC CC1G_00331_Ccin_TRRAP -------------LEA-----------------------------------------IPH AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP DDAGVRR------HAA-----------------------------------------RCC SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP DSSTLRI------KAA-----------------------------------------QTI GK009_Glam_PIKK-Unclassified TNPRVQSYYKLICRIADSCHTVATLNQSAQTSRYMLAYIFFQYFLVQVCGEKYHLITTTI TRRAP_Hsap_TRRAP CMAYEE-----KE----------------------------------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP SRLLTP-----SIHLIS------------------------------------------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP CMGHEE-----KE----------------------------------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP SRLLTP-----SIHLIS------------------------------------------- DNAPK_Mmus_DNAPK PVDSTLRDFCGRC----------------------------------------------- ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM MHLCTS-----CLCIHTK------------------------------------------ C47D12.1_Cele_TRRAP CLSETSSS---------------------------------------------------- B0261.2_Cele_FRAP CEMVVP-----FVGVYK------------------------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ---SEA-----TV----------------------------------------------- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM MQLCTR-----CLSNCTK------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK PVDSTLRDFCGRC----------------------------------------------- TOR_Dmel_FRAP TRLLKL-----AVQ--S------------------------------------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP CMAYEE-----KE----------------------------------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP CEIYVK-----DN----------------------------------------------- TOR2_Scer_FRAP CDLFIK-----DD----------------------------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK PLDGARRDFAGQC----------------------------------------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP AQLMVG-----TEE---------------------------------------------- TRRAP_Ddis_TRRAP VMSMSS-----HN----------------------------------------------- ATMa_Spur_ATM CSVLLP-----LY---AC------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP CMAHEE-----KE----------------------------------------------- CC1G_00839_Ccin_ATM MQKESQLQ---------------------------------------------------- CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP CTLFIK----------D------------------------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K LALC-------------------------------------------------------- CC1G_00331_Ccin_TRRAP GLAREQ-----PA----------------------------------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP CRLVEH-----SYQ--T------------------------------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP LKLMSE-----DHFEKIRRGKHSQYKSMTIKAEDCHSWAGSTLGEAPTPSGGATIIPPAV GK009_Glam_PIKK-Unclassified SELCM------EQIC--------------------------------------------- TRRAP_Hsap_TRRAP -------------------L---------------------------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------GH---------------------------------------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP -------------------L---------------------------------------- CG6535_Dmel_ATM ----------------------------------ICFDKDYATPFEIAIKKSYTSNLTAK CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------GH---------------------------------------- DNAPK_Mmus_DNAPK -------------------V---------------------------------------- ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM -------------------HTPNKIASGF-FLRLL------------------------- C47D12.1_Cele_TRRAP -------------------F---------------------------------------- B0261.2_Cele_FRAP ------------------KV---------------------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -------------------E---------------------------------------- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM -------------------KSPNKIASGF-FLRLL------------------------- ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK -------------------I---------------------------------------- TOR_Dmel_FRAP ------------------SE---------------------------------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP -------------------L---------------------------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP -------------------I---------------------------------------- TOR2_Scer_FRAP -------------------I---------------------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK -------------------L---------------------------------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP -------------------I---------------------------------------- ATMa_Spur_ATM -------------------QPGQQGEAGQMVASLV------------------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -------------------L---------------------------------------- CC1G_00839_Ccin_ATM -------------------S---------------------------------------- CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------PI---------------------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K -------IKLAPGDDLIMS----------------------------------------- CC1G_00331_Ccin_TRRAP -------------------Q---------------------------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------AI---------------------------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP VSNQSFATTISPKTR---HI---------------------------------------- GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM IVRCVGLIAQRCPDI----YLLENFAVICKSTAKFITMPT-------------------- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM -------------TS----KLMNDIADICKSLASCTKKPLDHG--------------V-H C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM -------------TS----KLMNDIADICKSLASFIKKPFDRG--------------EVE ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM -------------RSCTPAELLDALLDVLHKRGSCQ----KQGSKVTNHHDPFGDSMELG ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM PGEDDEDGGGCDSLMEAEGPSSTGLSTAYPASSVSDANDYGENQNAVGAMSPLAADYLSK C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM SMEDDTNG----NLMEVEDQSSMNLFNDYPDSSVSDANEPGESQSTIGAINPLAEEYLSK ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM SDDEFPSTQQAQGDLDDDFGEVTTISAQATTGTSEKKRHKSREDSMTGTHSMLSIESLPH ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM -----------------------------LEVRFATLFTFTILLE-SNCVTSDAIGHSR- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM QDHLLLDMLRFLG-RSVTASQSHTVSFRGADI----RRKLLLLLD-SSILD-----LMKP C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM QDLLFLDMLKFLC-LCVTTAQTNTVSFRAADI----RRKLLMLID-SSTLE-----PTKS ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM EEQLAISSAKVLSSWCWSCDFSDQVTSEARDNRTAVTQRLLKMFDDG------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ----------------------------------------------CKIGEVALAVIFDV SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ----------------------------------------------A------------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ----------------------------------------------CKPGIACMGIILDT CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ----------------------------------------------A------------- DNAPK_Mmus_DNAPK ----------------------------------------------QEFLKWSI------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM LHLHMYLVLLKDLPGNEHSLPMEDVVE-LLQPLSLVCSLHRRDQDVC------------- C47D12.1_Cele_TRRAP ----------------------------------------------IIAGVMSLRHINET B0261.2_Cele_FRAP ----------------------------------------------T------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ----------------------------------------------KKLQMYIPLIGRSF TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR --------------------------------------------------------ALKY ATM_Hsap_ATM LHLHMYLMLLKELPGEEYPLPMEDVLE-LLKPLSNVCSLYRRDQDVC------------- ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ----------------------------------------------REFLKWSI------ TOR_Dmel_FRAP ----------------------------------------------S------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ----------------------------------------------CKIGEVALAVIFDV smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ----------------------------------------------C------------- TOR2_Scer_FRAP ----------------------------------------------C------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ----------------------------------------------CEFAKWSL------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ----------------------------------------------P------------- TRRAP_Ddis_TRRAP ----------------------------------------------I------------- ATMa_Spur_ATM ---------------EDQDLTNSYEVQLTNGPRRELVSVNRKVQEVC------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ----------------------------------------------CKTGQLAMTVIVET CC1G_00839_Ccin_ATM ----------------------------------------------IRNFMLYAQLPSYK CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ----------------------------------------------C------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ----------------------------------------------CERAKEVVAILIND AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ----------------------------------------------T------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ----------------------------------------------R------------- GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP AS---------------------------------------------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ---HVVS----------------------------------------------------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP AT---------------------------------------------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ---HVVS----------------------------------------------------- DNAPK_Mmus_DNAPK --KQ-------------------------------------------------------- ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ---KTIL----------------------------------------------------- C47D12.1_Cele_TRRAP LS---------------------------------------------------------- B0261.2_Cele_FRAP ---SDKR----------------------------------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR AL---------------------------------------------------------- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ---KTIL----------------------------------------------------- ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK --KQ-------------------------------------------------------- TOR_Dmel_FRAP ---MENS----------------------------------------------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP AS---------------------------------------------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ---KQTS----------------------------------------------------- TOR2_Scer_FRAP ---KQTS----------------------------------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK --KN-------------------------------------------------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ---TPTR----------------------------------------------------- TRRAP_Ddis_TRRAP ---NQSNIEDLQTISTSKFNKAHITSLLDMIFNCSNQIFSENSNSKKNNELMTSSTDVKD ATMa_Spur_ATM ---AEAM----------------------------------------------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP AA---------------------------------------------------------- CC1G_00839_Ccin_ATM PS---------------------------------------------------------- CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ---YQAS----------------------------------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP LIEM-------------------------------------------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ---GRSA----------------------------------------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ---THSS----------------------------------------------------- GK009_Glam_PIKK-Unclassified ---KQTS----------------------------------------------------- TRRAP_Hsap_TRRAP ---------------------------------IILGSKERACQLPLFSY---------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ---------------------------------NIMGNKDRACKLPIIQY---------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ---------------------------------TTP--QQQEKSPVNSKS---------- ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ---------------------------------LTLPDIDQMSKVPMCKY---------- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ---------------------------------LGDDAALKVHGFLSNVL---------- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ---------------------------------ITP--QQQEKSPVNTKS---------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ---------------------------------IILGSKERACQLPLFSY---------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ---------------------------------TSV--KQQEKNAFNFKS---------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP GEKVEMETEDSLKKDEMSAAATSEIKKETNVVVENEQDKDTVLISPIFKY---------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ---------------------------------AVMGSKARACSLSIFEY---------- CC1G_00839_Ccin_ATM ---------------------------------EQSKSVSFPTSVEPGVE---------- CC1G_08126_Ccin_ATR -----------------------------------------------EPYTLRRILADVA CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ---------------------------------RTRPNIGLQGIFPLLHS---------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ---IVERLCACCYEQAWYAKLGGVVSI-KFLMERLPL----------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ---LAEKMVSLCYDRPWYSKVGGCQAI-QFLCKHMSL----------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ---LFKRLYSLALHPNAFKRLGAALAF-NHIYKEFREE---------------------- ATR_Mmus_ATR ---VLEELCGML-------------------------SLPWIYSYSDDNSLKMTTFATNL ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ---LMEKVFKLCHGPAWYARSGGINAI-GYMIESFPR----------------------- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ---SARLSSTVKATLFASSFAHSVLKN-CEIDWNVSY----------------------- TEL1_Scer_ATM ---PKVSLDLTR------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ---ILEDLCGML-------------------------SLPWIYSHSDDGCLKLTTFAANL DNAPK_Hsap_DNAPK ---LFKRLYSLALHPNAFKRLGASLAF-NNIYREFREE---------------------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ---IVERLCACCYEQAWYAKLGGVVSI-KFLMERLPL----------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ---ILKRIYSLAHHPDPYKRLGAAISF-NQLYRIFREE---------------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ---LVKLFIKCCYDKDFSVKGAGLIGI-EYIIENVKL----------------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ---VADRMCNCCYERAWYAKLGGCIAI-KFMMENMDM----------------------- CC1G_00839_Ccin_ATM ---PADISPLSSSRRSPNAREGRVLSFLERMIKALKL----------------------- CC1G_08126_Ccin_ATR ERFSRPL----SQADDESRIKLARNLA-KLPCLLVVCT---------------------- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K -------------------------------RKTVTG----------------------- CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ---LANRFTGLCLDESWIRKAAGCNGI-KLMLNAPVVA---------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP -----------------------------------------TWVLQNQQTFLKAL----- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR -------------------------------------IRLETPSSVHTQMQSFYAQQYMR CG2905_Dmel_TRRAP -----------------------------------------RALFQNLFNFLKAF----- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ----------------------------------------GSLVEQFVFEALVTY----- ATR_Mmus_ATR LPLSQRVWDSYSPQAQSKCVFLLTLFPRRIFLEWRTAVYNWALKSSHEVIRASCVKGFFI ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP -----------------------------------------KFVMDFVIDVVDSI----- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -----------------------------------------TWKTQFSQCLIKAP----- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR LTLSCRISDSYSPQAQSRCVFLLTLFPRRIFLEWRTAVYNWALQSSHEVIRASCVSGFFI DNAPK_Hsap_DNAPK ----------------------------------------ESLVEQFVFEALVIY----- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP -----------------------------------------TWVLQNQQTFLKAL----- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ----------------------------------------DSLVDQFIFEILHNI----- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP -----------------------------------------SWIQPFQHLILKSL----- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -----------------------------------------CWVQSHLYLFLKAL----- CC1G_00839_Ccin_ATM -----------------------------------------HWQS--------------- CC1G_08126_Ccin_ATR ----------------------------------------GESCTTFRNASGPSLLGFYV CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K -----------------------------------------AQTVPTLPL---------- CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ----------------------------------------QKWVSDREIELVRNL----- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ---LFVM-MDLTG----------------EVSN--------------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP --------------------------------Q--------------------------- mei-41_Dmel_ATR LFQSEETQEIFC------------------------------------------------ CG2905_Dmel_TRRAP ---MFVL-MDLEG----------------DVSN--------------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP --------------------------------Q--------------------------- DNAPK_Mmus_DNAPK ---MESLALAHED----------------EKSLG-------------------------- ATR_Mmus_ATR LLHQ----QNSC------------------------------------------------ ATM_Mmus_ATM ----S------------------------------------------------------- C47D12.1_Cele_TRRAP ---MEVI-LGTVE----------------EISS--------------------------- B0261.2_Cele_FRAP --------------------------------N--------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ---VGTC-E--------------------------------------------------- TEL1_Scer_ATM -----------YN----------------EILYR-------------------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ----N------------------------------------------------------- ATR_Hsap_ATR LLQQ----QNSC------------------------------------------------ DNAPK_Hsap_DNAPK ---MESLALAHAD----------------EKSLG-------------------------- TOR_Dmel_FRAP --------------------------------K--------------------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ---LFVM-MDLTG----------------EVSN--------------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP --------------------------------L--------------------------- TOR2_Scer_FRAP --------------------------------V--------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ---FFSLRIGDDL----------------TNTSS-------------------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP --------------------------------G--------------------------- TRRAP_Ddis_TRRAP ---LFVC-EDLSY----------------SGYQ--------------------------- ATMa_Spur_ATM ----A------------------------------------------------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ---LFVM-MDLTK----------------EVSS--------------------------- CC1G_00839_Ccin_ATM ------------------------------TPN--------------------------- CC1G_08126_Ccin_ATR PILQALL-AGPAD----------------EVTP--------------------------- CC1G_00894_Ccin_FRAP --------------------------------S--------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K -----HL-RSLRKPRLSDDPLGQLETDSFNTP---------------------------- CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ---MHAL-KDLPY----------------DLPR--------------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP --------------------------------SRLT------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP --------------------------------SHLDDMSSTSFCINQDCILSQDILKSSD GK009_Glam_PIKK-Unclassified --------------------------------V--------------------------- TRRAP_Hsap_TRRAP ------------------------GAV----------------------------AMAKT SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP -----------T-----------A--V----------------------------QVVAD mei-41_Dmel_ATR --------------------------------------------------S--------- CG2905_Dmel_TRRAP ------------------------GAI----------------------------EITKS CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP -----------T-----------A--V----------------------------QVVAD DNAPK_Mmus_DNAPK -----------------------TV-----------------------------QQ---- ATR_Mmus_ATR --------------------------------------------------N--------- ATM_Mmus_ATM -----------NVLHIVTNLGQGS------------------------------------ C47D12.1_Cele_TRRAP ------------------------GSA----------------------------DSAYD B0261.2_Cele_FRAP -----------S-----------L--L----------------------------QTIYG atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM -----------------------LLENIESDAFSSPLQKFTWVAKLIQIVD--------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM -----------HVLHVVKNLGQSN------------------------------------ ATR_Hsap_ATR --------------------------------------------------N--------- DNAPK_Hsap_DNAPK -----------------------TI-----------------------------QQ---- TOR_Dmel_FRAP -----------T-----------L--S----------------------------DTVSH SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------GAV----------------------------AMAKT smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP -----------H-----------S--L----------------------------NTVSE TOR2_Scer_FRAP -----------H-----------A--L----------------------------HSVSE TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK -----------------------SKNNSNSNSNNNNNNNNNSEDGTEDSIVEIASK---- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP -----------H-----------S--A----------------------------VIVGE TRRAP_Ddis_TRRAP -----------P-----------T--I----------------------------DYASE ATMa_Spur_ATM -----------FLRAITPHLAMSG------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------GAL----------------------------NMAKS CC1G_00839_Ccin_ATM ------------------------PTI----------------------------EVARR CC1G_08126_Ccin_ATR -----------------------SVRR----------------------------EVYSV CC1G_00894_Ccin_FRAP -----------H-----------A--I----------------------------EVISD CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K --------NMYS-----------L--L----------------------------NY--- CC1G_00331_Ccin_TRRAP ------------------------DVE----------------------------DVIET AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ---SGRPLTFRK-----------H--R----------------------------ILIEE SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP LGTDGFFNSGPY-----------R--H----------------------------MLISD GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP TLEQLLMRCA-------------------------------------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP VLSKL------------------------------------------------------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP YMKSMLEICL-------------------------------------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP VLSKL------------------------------------------------------- DNAPK_Mmus_DNAPK --------C--------------------------------------------------- ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP CLKKMMRVYF-------------------------------------------------- B0261.2_Cele_FRAP VLRAV------------------------------------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK --------C--------------------------------------------------- TOR_Dmel_FRAP VIERL------------------------------------------------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP TLEQLLMRCA-------------------------------------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP VLSKL------------------------------------------------------- TOR2_Scer_FRAP VLSKL------------------------------------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK --------Y--------------------------------------------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP VLEKL------------------------------------------------------- TRRAP_Ddis_TRRAP IIINLIKLCVPNLNIVPDSMEIDQSTTTASTTETAATTTTTETATPMVTESTAIVTEPTA ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP NVDLVLKLCA-------------------------------------------------- CC1G_00839_Ccin_ATM TLD--------------------------------------------------------- CC1G_08126_Ccin_ATR LL-PVLK----------------------------------------------------- CC1G_00894_Ccin_FRAP VLDKL------------------------------------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ----------------------------------------------------------SH CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP LL-DVLRLS--------------------------------------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ILEKL------------------------------------------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP TLRQI------------------------------------------------------- GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP TTPTATPTSTPTSTSTPTPTPIPTATTSSTTTAPTTTTTTTTNLSSSSTINQKPHCKLNQ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K SSPSL------------------------------------------------------- CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP -----------------T--------------------------------PLKD-EE--- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ---------------LVV------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP -----------------T--------------------------------PINE-CY--- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ---------------LVV------------------------------------------ DNAPK_Mmus_DNAPK --------------------------------------------------------CDAI ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ---------------------------------------------------IKE-E---- B0261.2_Cele_FRAP ---------------CSV------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -----------------EALQIMFKRYSTIFTRCFLNRLFFDASSAGAQKPSY-DEH--- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK --------------------------------------------------------CDAI TOR_Dmel_FRAP ---------------LMV------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP -----------------T--------------------------------PLKD-EE--- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ---------------LAI------------------------------------------ TOR2_Scer_FRAP ---------------LMI------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK --------------------------------------------------------SNVL SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ---------------LVV------------------------------------------ TRRAP_Ddis_TRRAP LKLKDRELLKLILEILME------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -----------------T--------------------------------PPTGADA--- CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ---------------LTV------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP --------------------------------------------------------NS-- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ---------------LVA------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ---------------III------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------RAEE-- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------KNID-- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK DHLRRIIEKKHVSLNKAKKRRLPQGFPPLT------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP -----------------------------------------------------GQEEENL B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------RIRE-- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK DHLCRIIEKKHVSLNKAKKRRLPRGFPPSA------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------RAEE-- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK AALTKVIIK--------------------RADMLN--------------KPSNTRR---- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------ENPK-- CC1G_00839_Ccin_ATM ----------------------------------------------------------FA CC1G_08126_Ccin_ATR --------------------------------------------------HRNEEEPD-- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP --------------------------------------------------SLDFTGDG-- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK -----------------------------REMARTSFKFACFCDDLLNTADD-------- FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP -IVAAQEKSFHHVTHDLVREVTSP------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP -------------------GITDP------------------------------------ mei-41_Dmel_ATR -----------NLPQLYISGFIK------------------------------------- CG2905_Dmel_TRRAP -LKDLQAKATYEVIHELVRHITSP------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP -------------------GITDP------------------------------------ DNAPK_Mmus_DNAPK -----SLCLLDLVEWLLA-HCGRP------------------------------------ ATR_Mmus_ATR -----------QIPKMLVDRVKDD------------------------------------ ATM_Mmus_ATM -----------------------VD----MESTRIAQGHFLTVMGAFWHLTKEKKCVFSV C47D12.1_Cele_TRRAP TLATI-------FVSAISKHYFHS------------------------------------ B0261.2_Cele_FRAP -------------------IVNDQ------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -I---------------------------------------------------------- TEL1_Scer_ATM -----------NLCGDSTFSEFIA------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM -----------------------MD----SENTRDAQGQFLTVIGAFWHLTKERKYIFSV ATR_Hsap_ATR -----------RVPKILIDKVKDD------------------------------------ DNAPK_Hsap_DNAPK -----SLCLLDLVKWLLA-HCGRP------------------------------------ TOR_Dmel_FRAP -------------------AITDM------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP -IVLAQEKSFHHVTHDLVREVTSP------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP -------------------TIADP------------------------------------ TOR2_Scer_FRAP -------------------AITDP------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ---E-HKDLSQFVQWVFQNGCSRT------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP -------------------GIADP------------------------------------ TRRAP_Ddis_TRRAP -------------------RITSW------------------------------------ ATMa_Spur_ATM -----------------------SDDGMVSSDIKVCRDVALLLLAAFWQLQATY--STPV ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -LAVAQQKAFHDVTRELVREVTSP------------------------------------ CC1G_00839_Ccin_ATM VIAI-------------------------------------------------------- CC1G_08126_Ccin_ATR -E---------PVLEMITRGVTDD------------------------------------ CC1G_00894_Ccin_FRAP -------------------GIADP------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP -AAH-ARNKIVHLAGMFFPEFQSS------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -------------------AVSDT------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP -------------------GTTDI------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ----------------------------------------NSTVR-------------KQ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ----------------------------------------DPDIR-------------YC mei-41_Dmel_ATR --------------------------------------------PEQLMKALPTINNRSG CG2905_Dmel_TRRAP ----------------------------------------NTIVR-------------EE CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ----------------------------------------DPDIR-------------YC DNAPK_Mmus_DNAPK ----------------------------------------QTECR-------------HK ATR_Mmus_ATR ----------------------------------------SDMVK-------------KE ATM_Mmus_ATM RMALVKCLQTLLEADPYSEWAILNVKGQD---------FPV------------------- C47D12.1_Cele_TRRAP ----------------------------------------NERVR-------------EF B0261.2_Cele_FRAP ----------------------------------------DVRVR-------------MQ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ----------------------------------------AYKRTTLITIPQLSFDSQNS MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM RMALVNCLKTLLEADPYSKWAILNVMGKD---------FPV------------------- ATR_Hsap_ATR ----------------------------------------SDIVK-------------KE DNAPK_Hsap_DNAPK ----------------------------------------QTECR-------------HK TOR_Dmel_FRAP ----------------------------------------DCNVR-------------IR SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ----------------------------------------NSTVR-------------KQ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ----------------------------------------LQDIR-------------LE TOR2_Scer_FRAP ----------------------------------------VAEIR-------------LE TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ----------------------------------------ESIVR-------------YE SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ----------------------------------------DPSIR-------------KT TRRAP_Ddis_TRRAP ----------------------------------------SGHTR-------------SL ATMa_Spur_ATM KHQMALCIEALIKIDPDSQWTFIKAKGREKGHGDSNERSEV------------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ----------------------------------------NQTVR-------------EQ CC1G_00839_Ccin_ATM --------------------------------------------V-------------FQ CC1G_08126_Ccin_ATR ----------------------------------------DRAVR-------------VQ CC1G_00894_Ccin_FRAP ----------------------------------------DPGIR-------------NV CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ----------------------------------------NRIIR-------------DA AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ----------------------------------------DASVR-------------ED SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ----------------------------------------DPEVR-------------MS GK009_Glam_PIKK-Unclassified -----------------------------------------------------------A TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified FCLFSSAYLPSLIINLYLPLSRTALSKELALLCVESRTPVMMSYPRLSVEDFVTVTGALA TRRAP_Hsap_TRRAP AMHSL-Q----------------------------------------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP VLASL-D----------------------------------------------------- mei-41_Dmel_ATR RAQVIRLLLCSQPGKLSVFKVK-----------DRIELYCPKCRP--------------- CG2905_Dmel_TRRAP SMVLL-K----------------------------------------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP VLASL-D----------------------------------------------------- DNAPK_Mmus_DNAPK SMELF-YKFVPLLPGN------KSPSLWLKDLI--KKKGISFLINTFE--G---GASSSD ATR_Mmus_ATR FASVLGQLVCTLHGMFYLSS-SV----EPCFE--HMDLFSKNLKATSQHECSSSQ----- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP AIGLM-D----------------------------------------------------- B0261.2_Cele_FRAP VISCF-G----------------------------------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM YQSFFEEVLSIRTINVDHLVLDK----INMKEI--VNDFIRMQKNK--SQTGTSA----- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR FASILGQLVCTLHGMFYLTSSLT----EPFSEHGHVDLFCRNLKATSQHECSSSQ----- DNAPK_Hsap_DNAPK SIELF-YKFVPLLPGN------RSPNLWLKDVL--KEEGVSFLINTFE--G---GGCG-- TOR_Dmel_FRAP ILRSL-D----------------------------------------------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP AMHSL-Q----------------------------------------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP VLKNL-N----------------------------------------------------- TOR2_Scer_FRAP ILQHL-G----------------------------------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK SMILF-TQLVTLLPNI------KTPLQWVKERI--KSNGIQFIVSIAEQQG---GGV--- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP VLSSL-E----------------------------------------------------- TRRAP_Ddis_TRRAP AQRML-T----------------------------------------------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP AMDSL-R----------------------------------------------------- CC1G_00839_Ccin_ATM TM--L-S----------------------------------------------------- CC1G_08126_Ccin_ATR AGLTL-Q----------------------------------------------------- CC1G_00894_Ccin_FRAP VLRGL-H----------------------------------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K IAATS-K----------------------------------------------------- CC1G_00331_Ccin_TRRAP AQRCI-N----------------------------------------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP VFVSL-G----------------------------------------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP IIQAL-T----------------------------------------------------- GK009_Glam_PIKK-Unclassified ILSCV-D----------------------------------------------------- TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK QP---------------------------------------------------------- ATR_Mmus_ATR --V-------------------------------------------KA------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM --INYFEASSEDTTQNNSPYTIGGRFQKPLHSTIDKAVRAYLWSSRNK------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR --L-------------------------------------------KA------------ DNAPK_Hsap_DNAPK QP---------------------------------------------------------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK -GGG-------------------------------------------SSNGNTSLGRIPK SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK --------AGILAQPTLVYLQGPISLRGVLQWLDLLLAALECYNTFIEKETVQGQEVLGA ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK --------SGILAQPTLLYLRGPFSLQATLCWLDLLLAALECYNTFIGERTVGALQVLGT TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK IEIGKHKDI--------------------EFWFRNLSTSLNIYLWFFSEGFFEPIQILTS SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------VLA-QV SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------HIG-TI CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK -EVQSSLL-----------------------KSVAFFLESIATHSARAVEQRFGSGA-PG ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------HCM-VH B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK -EAQSSLL-----------------------KAVAFFLESIAMHDIIAAEKCFGTGA-AG TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------VLA-QV smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK REFKSSLLSSA-----------FHTFTTQFSMLNFNSNLKTNQQQQQQQVSMFSSM---- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------MISVEI ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------WLA-DF CC1G_00839_Ccin_ATM ------------------------------------------------------VNS-VI CC1G_08126_Ccin_ATR ------------------------------------------------------AVV--- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------YMV-TL AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP -----------------------------------------------------------V ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK SKWKSEVRRSIQDSRQSFGVTSFSVFREAMVTNML------------------------- FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP T---GKSV-------------T-----VIMEPHKE------------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR -------------------------------------LPKKLPGIYLGKCKQQLPCPDFS CG2905_Dmel_TRRAP Q---SKTV-------------S-----EVMDPHKD------------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK P----PSLHEEEKYNYSKCTVL-----VRIMEFTT------------------------- ATR_Mmus_ATR ----------------STCKPF-----LFLL-TKNTPSPV-------------------- ATM_Mmus_ATM ---------------------------------NE------------------------- C47D12.1_Cele_TRRAP SRLAP-----------------------SLDKFYY------------------------- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ----TRCY-------------LSHVLSDFNFPNQK------------------------- TEL1_Scer_ATM ----------------SISERL-----VAILEFSDCVST--------------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ---------------------------------NE------------------------- ATR_Hsap_ATR ----------------SVCKPF-----LFLL-KKKIPSPV-------------------- DNAPK_Hsap_DNAPK N---RTSPQEGERYNYSKCTVV-----VRIMEFTT------------------------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP T---GKSV-------------T-----VIMEPHKE------------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------TPKEIDQFNRLKCNVI-----TNLFGLYI------------------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP T---KIPM-------------S-----QLIEDLKM------------------------- ATMa_Spur_ATM ---------------------------------AT------------------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP T---DKKV-------------M-----EIMSPHKE------------------------- CC1G_00839_Ccin_ATM T---GKE---------------------VLKVGAE------------------------- CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ---------------------T-----SALMSGRP------------------------- CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP S---GRTP-------------G-----ELFLPHRE------------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP T---GRTV-------------A-----SIIEPHKE------------------------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP -----------VL-------------------------------------------QDMV SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR STNLEMIANDLLFYPDFECIAQHLDLLCFE--PNVILGLLRETEALQKVSVKVIGQL--- CG2905_Dmel_TRRAP -----------VL-------------------------------------------ADII CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK -----------TL-------------------------------------------LIAS ATR_Mmus_ATR ---------KLAFIDNLHHLCKHLDFQEDEREVKA-----------------VLGTL--- ATM_Mmus_ATM -----------AF-------------------------------------------SQFL C47D12.1_Cele_TRRAP -----------RF-------------------------------------------KEFF B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -----------IT-------------------------------------------FNMI TEL1_Scer_ATM ----------DVFISYLGTVCQWLK----------------------------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM -----------VF-------------------------------------------TQFL ATR_Hsap_ATR ---------KLAFIDNLHHLCKHLDFREDETDVKA-----------------VLGTL--- DNAPK_Hsap_DNAPK -----------TL-------------------------------------------LNTS TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP -----------VL-------------------------------------------QDMV smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK -----------LL-------------------------------------------L--- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP -----------TV-------------------------------------------QKLL ATMa_Spur_ATM -----------LF-------------------------------------------PNLL ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -----------VL-------------------------------------------ADMI CC1G_00839_Ccin_ATM -----------VL-------------------------------------------NLVV CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K -----------LR-------------------------------------------SAMM CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP -----------RM-------------------------------------------LAGV AqueK043_Aque_ATM ----------------------------------------------------------FI AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP -----------LL-------------------------------------------IDMI ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP PP-KKHLLR-HQPAN---A--QIGLME---GN---------TFCTTL--Q-P--RL---- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ----------------------------------------------ERFDA---HL---- mei-41_Dmel_ATR ---------------------VSAMRVRSPEFLEQLANLVLAAI-KAMLA-K--PL---- CG2905_Dmel_TRRAP PP-KKHLLR-HQPAN---A--QIGLMD---GN---------TFCTTL--E-P--RL---- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ----------------------------------------------ERFDA---HL---- DNAPK_Mmus_DNAPK PE-DCKLLE-KD-------------------------------------------LCNTN ATR_Mmus_ATR ---------------------LNLMEDPDKDVRI----AFSGNI-KYILE-S--LN---- ATM_Mmus_ATM AD-DHHQ----------------------------------------------------- C47D12.1_Cele_TRRAP EPELMRVLT-TVPTMSLAD--AGGSLD---GV---------QNYMFN--C-P--DG---- B0261.2_Cele_FRAP -----QM--------------------------------------PRPFLA---HL---- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR RP-S-------------------------------------------------------- TEL1_Scer_ATM ---------------------------------------QAIGE-KSS------------ MEC1_Scer_ATR ------------DNK---FNIWVYQSEPDSSL---------KNV-TSPFD-D--RY---- ATM_Hsap_ATM AD-NHHQ----------------------------------------------------- ATR_Hsap_ATR ---------------------LNLMEDPDKDVRV----AFSGNI-KHILE-S--LD---- DNAPK_Hsap_DNAPK PE-GWKLLK-KD-------------------------------------------LCNTH TOR_Dmel_FRAP ----------------------------------------------ETFDG---KL---- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP PP-KKHLLR-HQPAN---A--QIGLME---GN---------TFCTTL--Q-P--RL---- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ----------------------------------------------PCFDP---QL---- TOR2_Scer_FRAP ----------------------------------------------SNFDP---QL---- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ---------------------------------------FINNL-NFIYD-L--II---- DNAPK_Ddis_DNAPK -E-KYKFEQVID-------------------------------------------YGGVA SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ----------------------------------------------ARFDH---YL---- TRRAP_Ddis_TRRAP PK-T--P--------------------------------------LKSLS----IS---- ATMa_Spur_ATM QD-STHE----------------------------------------------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP PP-KKHLLR-HQPAN---A--QRGLMD---SN---------TFCTTL--E-P--RL---- CC1G_00839_Ccin_ATM NP-SAM----GPNGN---A--KWTLAE---RA---------TLCEGL--E-P--LV---- CC1G_08126_Ccin_ATR ----------------------------------------------EFYSGN--TL---- CC1G_00894_Ccin_FRAP ----------------------------------------------ERFDK---HL---- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K NP-ADIL--------------------------------------LERYD----HE---- CC1G_13883_Ccin_PI4K ----------------------------------------------EVYDA---SL---- CC1G_00331_Ccin_TRRAP Y---TKPLR-ALPFL---K--QIGIME---SM---------RYCLKL--E-P--QV---- AqueK043_Aque_ATM VD-ADHS----------------------------------------------------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP PP-KKHLLK-HQPIN---T--QIALMD---GY---------TFCCNL--S-P--RL---- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -----T---------------------------------------NGSFYD---FL---- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP -----T---------------------------------------TNRYDI---YL---- GK009_Glam_PIKK-Unclassified ----------------------------------------------STIASALAYH---- TRRAP_Hsap_TRRAP -------------------FTMD------------LNVV--------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ---------------------AQ------------AE----------------------- mei-41_Dmel_ATR ---------------------TE------------QN----------------------- CG2905_Dmel_TRRAP -------------------FTID------------LTNT--------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ---------------------AQ------------AE----------------------- DNAPK_Mmus_DNAPK LMQVLVKMICEPMSLGFNIGD--------------VQVM--------------------- ATR_Mmus_ATR ---------------------SE------------DG----------------------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP -------------------FDFE------------KDMD--------------------- B0261.2_Cele_FRAP ---------------------AQ------------PE----------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ---------------------KQ------------LE----------------------- ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ---------------------SE------------DG----------------------- DNAPK_Hsap_DNAPK LMRVLVQTLCEPASIGFNIGD--------------VQVM--------------------- TOR_Dmel_FRAP ---------------------AQ------------PE----------------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP -------------------FTMD------------LNVV--------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ---------------------AQ------------PD----------------------- TOR2_Scer_FRAP ---------------------AQ------------PD----------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ----------------------Q------------QK----------------------- DNAPK_Ddis_DNAPK FVQLLVKCLMDPQSVGFV--------------------NNYLEEREVELSKSSRQDIRNL SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ---------------------AQ------------AE----------------------- TRRAP_Ddis_TRRAP ---------------------LQ------------TG----------------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -------------------FTMD------------PTIP--------------------- CC1G_00839_Ccin_ATM -------------------WTSD------------PPVE--------------------- CC1G_08126_Ccin_ATR ---------------------AS------------RQ----------------------- CC1G_00894_Ccin_FRAP ---------------------AQ------------AE----------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ---------------------AQ------------TQ----------------------- CC1G_13883_Ccin_PI4K ---------------------FDVKGDFVGDTHKTLH----------------------- CC1G_00331_Ccin_TRRAP -------------------IDAS------------EE----------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP -------------------FSIN------------LSVP--------------------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ---------------------AQ------------AD----------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ---------------------VH------------ES----------------------- GK009_Glam_PIKK-Unclassified ---------------------AS------------PK----------------------- TRRAP_Hsap_TRRAP -------------E------------------HKV----------------FYTE----- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP -----------NLQ-------------------------------------ALFVAL-ND mei-41_Dmel_ATR -----------VLQ-------------------------------------QRSMLN--- CG2905_Dmel_TRRAP -------------Y------------------HKL----------------FFHE----- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP -----------NLQ-------------------------------------ALFVAL-ND DNAPK_Mmus_DNAPK ----------NH------------------------------------------------ ATR_Mmus_ATR -----------FVK-------------------------------------ELFVLR--- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP -------------M------------------YKR----------------YLSH----- B0261.2_Cele_FRAP -----------MLE-------------------------------------VQFMAL-HD atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ----------------------------------LLYWSLLSSARGINSKLTLSV----- TEL1_Scer_ATM ------------------------------------------------------YNK--- MEC1_Scer_ATR -----------KLR-------------------------------------LLVL----- ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR -----------FIK-------------------------------------ELFVLR--- DNAPK_Hsap_DNAPK ----------AH------------------------------------------------ TOR_Dmel_FRAP -----------SLN-------------------------------------SLFITL-HD SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP -------------E------------------HKV----------------FYTE----- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP -----------NLR-------------------------------------LLFTAL-HD TOR2_Scer_FRAP -----------NLR-------------------------------------LLFMAL-ND TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR -----------ELD-------------------------------------NLFLEVLM- DNAPK_Ddis_DNAPK MSRTFKFPPLLE------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP -----------NLR-------------------------------------SLFIAL-ND TRRAP_Ddis_TRRAP -----------VID------------------G------------------LTFC----- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -------------E------------------HKV----------------FFTE----- CC1G_00839_Ccin_ATM -------------TGWEAVAQPDFSRDGVTRKE--------------------------- CC1G_08126_Ccin_ATR -----------NIE-------------------------------------NFFHRL-Y- CC1G_00894_Ccin_FRAP -----------NVR-------------------------------------SLFIAL-ND CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K -----------LLR-------------------------------------NHFC----- CC1G_13883_Ccin_PI4K -----------SLQ-------------------------------------SGLHGL-SE CC1G_00331_Ccin_TRRAP -----------LLR-------------------------------------LLHE----- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP -------------E------------------HKV----------------FFQE----- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -----------CLK-------------------------------------AIFIAF-ND SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP -----------SLR-------------------------------------TLFIAL-YD GK009_Glam_PIKK-Unclassified -----------DLS-------------------------------------LSDATL-HD TRRAP_Hsap_TRRAP -LL--------------------------------------------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP QVFE-IRELAI------------------------------------------------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP -LL--------------------------------------------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP QVFE-IRELAI------------------------------------------------- DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM -----VRMLAAGSVNRLFQDMRQGDFSRSLKALPLKFQQTSFNNAYTTAEAGIRGLLCDS C47D12.1_Cele_TRRAP -LL--------------------------------------------------------- B0261.2_Cele_FRAP EKLE-MQQACV------------------------------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -ID--------------------------------------------------------- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR -KK--------------------------------------------------------- ATM_Hsap_ATM -----VRMLAAESINRLFQDT-KGDSSRLLKALPLKLQQTAFENAYLKAQEGMREMSHSA ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP EIFE-IRELAM------------------------------------------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP -LL--------------------------------------------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ESFN-IQSVAM------------------------------------------------- TOR2_Scer_FRAP EIFG-IQLEAI------------------------------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR DLLKLSSTVEI------------------------------------------------- DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ELFE-IRELAI------------------------------------------------- TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM -----VRMHMATAVGCLFNTPG-TQ------PYKTETQNQAFNLVYQYVEEAMQ-ISDDF ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -LM--------------------------------------------------------- CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR QVFE-------------------------------------------------------- CC1G_00894_Ccin_FRAP EVMA-NREAAV------------------------------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K --DE-KRLIGI------------------------------------------------- CC1G_00331_Ccin_TRRAP -AL--------------------------------------------------------- AqueK043_Aque_ATM -----VRLHLARNITVLFPETNTP----------LEHMNNFNDLKDMLRKST-L-VKSNL AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP -LI--------------------------------------------------------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP QSFE-VRKLSI------------------------------------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP DNIE-IRILAV------------------------------------------------- GK009_Glam_PIKK-Unclassified ALVV-------------------------------------------------------- TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------THWDFCQELYESIEFKKLTYNNEDAIQNSNALIVQMLIAIFLRSSFHQEIALKE CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM QNPDLLD-----------------------EIYNRKSVLLMMIAVVLHCSPVCEKQALFA C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ENPETLD-----------------------EIYNRKSVLLTLIAVVLSCSPICEKQALFA ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM GEAESKE-----------------------ETKNRTASLLRTLANVALSSHVCEKKTIFA ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM DEHSSED-----------------------ESVNRVASMLCTLQSVACSARSCEYHVISL AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------CTVGRLSSMN---------------------------P-AF----VMP mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM LLHHCALRRLTEKDIERCSKS-------------------------------ISEELALP CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------CTVGRLSSMN---------------------------P-AF----VMP DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM LC---------------------------------------------------------- C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------TLLGRLAELN---------------------------P-AL----VLP atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM LC---------------------------------------------------------- ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------VTIGRLSSIN---------------------------P-AY----VMP SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------ELVGRLSSVN---------------------------P-AY----VIP TOR2_Scer_FRAP ------------KIIGRLSSVN---------------------------P-AY----VVP TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------EYLHRISTLKSNEQLLESLFKLSTIVTNHSTIFNLTKY-AE----IIN DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------TVIGRLTIRN---------------------------P-AY----VMP TRRAP_Ddis_TRRAP -----------------LSQKP---------------------------SPLI----EIG ATMa_Spur_ATM LL---------------------------------------------------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------GLIGRLAKHN---------------------------P-AY----VMP CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K -----------------MSEVS---------------------------L-AF----TLP CC1G_13883_Ccin_PI4K ------------STISVVTRLA---------------------------L-EF----QME CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM LV---------------------------------------------------------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------VMAGKLSDKN---------------------------A-AY----VCP SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------KLIGRLCSLN---------------------------P-AL----VTP GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP FL---------------------------------------------------------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ILA--------------------------------------------------------- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP FL---------------------------------------------------------- DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP RL---------------------------------------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP KL---------------------------------------------------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP SI---------------------------------------------------------- TOR2_Scer_FRAP SL---------------------------------------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR SI---------------------------------------------------------- DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP SL---------------------------------------------------------- TRRAP_Ddis_TRRAP A----------------------------------------------------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP SL---------------------------------------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K LL---------------------------------------------------------- CC1G_13883_Ccin_PI4K EV---------------------------------------------------------- CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP AL---------------------------------------------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP EI---------------------------------------------------------- GK009_Glam_PIKK-Unclassified -AILFLTVLYADTEALAGAKTLKKVELVTSSIKAIKELVALPIFANVKPHKLFSEGIESY TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ----------RK------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM -----------SFLLIKNSSCSESEGQNFKEHLQLLSENLSY-SQLNA------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ----------RK------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ----------------KSVKENRLEPHLVKKVLEKVSESFGC-RSLEDFMISHLDYLVLE C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ----------RL------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ----------------KSVKENGLEPHLVKKVLEKVSETFGY-RRLEDFMASHLDYLVLE ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ----------RT------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ----------RK------------------------------------------------ TOR2_Scer_FRAP ----------RK------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ----------KV------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ----------RK------------------------------------------------ TRRAP_Ddis_TRRAP ----------DT------------------------------------------------ ATMa_Spur_ATM ----------------LTTKINKIPSSVMKKVLSCIAEGMSHCSSGPELATLHLGFLVYQ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ----------RK------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ----------RL------------------------------------------------ CC1G_13883_Ccin_PI4K ----------TR------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ----------------TSTGQGHMNSDIVKKVIRRISEYLG-YANEICLLEEMLSYLVSQ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ----------RR------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ----------RH------------------------------------------------ GK009_Glam_PIKK-Unclassified NGATAHIFRLLS------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ----------------------------M--LIQILTELEH------------------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ----TDVDLDLDILCYVISMLHDPQEMMR------------------------------- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ----------------------------M--LIQILTELEH------------------- DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM WLNLQDTEYS-------------------------------------------------- C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ----------------------------M--LLETLSQMQQ------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM WLNLQDTEYN-------------------------------------------------- ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ----------------------------T--MIELITDLKY------------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ----------------------------I--LLELLTKLKF------------------- TOR2_Scer_FRAP ----------------------------T--LLELLTQLKF------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ----------------------------I--SFSLVCWLPCSYYVNERVDIVLSTLSLNK DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ----------------------------T--LIQLLTELEF------------------- TRRAP_Ddis_TRRAP ----------------------------VR----VLQECLN------------------- ATMa_Spur_ATM WLQ---ESYE-------------------------------------------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ----------------------------A--LIQLLTELEY------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ----------------------------TDNKVQFLLSLEN------------------- CC1G_13883_Ccin_PI4K ----------------------------L--TIS-------------------------- CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM WMN----EGT-------------------------------------------------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ----------------------------H--LQQLLTDMEH------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ----------------------------L--ILVLLTELRL------------------- GK009_Glam_PIKK-Unclassified ----------------------------V--IFILMTAL-F------------------- TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM --------------------------------------ILEEFTEVLGEKLLCNHYSSSN MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR SLVNSTTTTTTTTTTTTTTTTTTATTNTTTTTATTTDKSSSQQNVGESNKN--------- DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ----------------------------------------VLTAIA-------------- CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ----------------------------------------MKEAYT-------------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM QAMLLLTSYIEAIRPQWLSYPEQPLNSDCNDILDWIISRFEDNSFT-------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ----------------------------------------MKEAYT-------------- DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR -------------------------NPTIVSSSPILVNISSDTSSSMGDSQAISASQQQQ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR RNNNNNNKGEKYLSKLDQNYLINVIKLLPVFISNMSPVNSLATISTNHQYQIMCNDIIKR DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR LESIIDLNVTSLILDMVGVIGGSLYCLKEGYCFFENLNRCTYLNNNNNNNNNNNNNNNNN DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR NNNNNNIQEQNNLIIINNSILLQRFTDTKNNRIKIDPLLSNYNNLVGCGIFEGVWLPLCS DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR CKCVTVSSVLNTNIVDLNLKPYRPIHKSPPSNNNNNNNEKDETIMDIDKTNNNEQILILE DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR SKYKENILFSKLFLEYHDGQNSDLDNDTSMMTSGGGDGDHDSSIKYFYLGFTFKNILIHN DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR SPLPSTSIEGFFKFYLNLLSANRNDIIRKSVIKIIISMLKFNYQTNPDVLTNFFYQLHPL DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR -------------------------------------------------------HME-- CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR -------------------------------------------------------HAQIA ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM -------------------------------------------------------GVAPT MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR -------------------------------------------------------HAQIS DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR YSNKSEREDILFSILYLLKKIANLIIQSQKDQYILNNSLNNNNNNNNNNNVQQLSSSSSS DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR -----------------------------------------------------------G CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP --NLC-EAEDSA----LTK-LPCYKS--------------LPSLVPLRIAALNALAAC-- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR --------------------DNEIWL--------------FHWFKM---TFFFLV----- CG2905_Dmel_TRRAP --TLS-EAEDAT----LAK-LDCYKN--------------VPNLIPLRTSALRALAAC-- CG6535_Dmel_ATM --------------------------------------------------LFGSLAIC-- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ----------------------------------------------LPSICVNLLKALRK ATR_Mmus_ATR RNNEL-KDTLIL----TTGDIGRAAK--------------GDLIPF---ALLHLL----- ATM_Mmus_ATM ---------------------------------------------------LSSFPFM-- C47D12.1_Cele_TRRAP --DIA-QTDTFTL----NQ-RNAFKKCETCPSHFLPPFPITTHIDSMRASALQCLVIA-- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR --FICQEMSAAS----VSM-SSISPN--------------PS------------------ TEL1_Scer_ATM VNLSM-LLLSLL----QNHDLSHGSI--------------RGGKQR---VFATFI----- MEC1_Scer_ATR --FNK-TERGTL----LKYRVNQLSP--------------GFFQR--------------- ATM_Hsap_ATM ---------------------------------------------------LSSFPFI-- ATR_Hsap_ATR RNNEL-KDTLIL----TTGDIGRAAK--------------GDLVPF---ALLHLL----- DNAPK_Hsap_DNAPK ----------------------------------------------LPDVCVNLMKALKM TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP --NLC-EAEDSA----LTK-LPCYKS--------------LPSLVPLRIAALNALAAC-- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR HNNQL-NNNNTT----TTNNDSITWQ--------------DKIYSN---DFILII----- DNAPK_Ddis_DNAPK ----------------------------------------------IINNIIKLLIQI-K SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ---VA-GDESSPTQQSQIK-SSSAKS--------------ISATNNLRVCGVEMVATA-- ATMa_Spur_ATM ---------------------------------------------------IREFPYG-- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP --NLC-ETEDSG----LVK-LPCYKA--------------VPSLVPLRISALNALAAC-- CC1G_00839_Ccin_ATM ------------------------RSL--------------PSVT--------------- CC1G_08126_Ccin_ATR CRHSI-KETLLI----SVGSLGKTAN--------------PFILGS---TLCLLI----- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ---IC-NR-----------------L--------------LVVPRPARVSALRA------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP --ALA-DAEDVQ----LVGPRTTRSS--------------ALEILKLRESCIKLLTAA-- AqueK043_Aque_ATM ---------------------------------------------------IDGFPYT-- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP --TLCGEGDDAA----LAK-SPCYKG--------------VQSLVPLKISGLAALAAC-- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP N-------Y------LP-------------------------------Q--------SRE SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP H-------Y------IS-------------------------------DI------GYKE CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK SPYRDMLE--------T-------------------------------H--------LKE ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP Y-------DRMKKQYIDKGIELGDEHKMIEILALRSSKITVDQVYESDE--------SWR B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK SPYKDILE--------T-------------------------------H--------LRE TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP N-------Y------LP-------------------------------Q--------SRE smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK PKYNDILH--------K-------------------------------E--------LME SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP M-------T------CP-------------------------------DFLQFECLEFKN ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP R-------Y------IP-------------------------------Q--------ARE CC1G_00839_Ccin_ATM ------------------------------------------------D--------AKE CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP MPITDFFGK------IP-------------------------------H--------TRQ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP T-------Y------LT-------------------------------E--------MRE ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP KIIAAL--------FKALNSTNSELQEAGEACM---RKFLEGA-TI-------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP -------------------SGIGRIKEQS------------------------------- mei-41_Dmel_ATR ---------------HTRSLVAQEAVLAAT---EMCASQGLQTIHL-------------- CG2905_Dmel_TRRAP KIINII--------FKVMESDKSELQTTAFHCM---KHFITGV-TL-------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP -------------------SGIGRIKEQS------------------------------- DNAPK_Mmus_DNAPK KVTVQS--------VE-------------------------------------------- ATR_Mmus_ATR --HC-L--------LSKSASVSGAAYTEIR---ALVAAKSVKLQNF-------------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP RLMTVL--------LRAVTD-------------------------R-------------- B0261.2_Cele_FRAP -------------------SGQARLEQHS------------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM --KC-LQKLDSSNII--------------------------------------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR --HC-L--------LSKSASVSGAAYTEIR---ALVAAKSVKLQSF-------------- DNAPK_Hsap_DNAPK KITAQS--------IE-------------------------------------------- TOR_Dmel_FRAP -------------------SGMSRNKEQS------------------------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP KIIAAL--------FKALNSTNSELQEAGEACM---RKFLEGA-TI-------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP -------------------STSSREKEET------------------------------- TOR2_Scer_FRAP -------------------SNMPKKKEES------------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR --FCTL--------IE-----------------NLSRQTTIKVNSIETIEFIAKKLNQTP DNAPK_Ddis_DNAPK YILPNN------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP -------------------SGDGRNKEES------------------------------- TRRAP_Ddis_TRRAP RIIRMF--------FKVVTARNKEMAMAAKRGL---ANSIQQQ-RL-------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP RIFKIL--------FNALNSNVSELQEAGAKCM---EKFIAGQ-PV-------------- CC1G_00839_Ccin_ATM ELRRNI--------LRAIWS---------------------------------------- CC1G_08126_Ccin_ATR --------------LQLGQSNLLLHSLACTQLLNISRHHKKSIYSL-------------- CC1G_00894_Ccin_FRAP -------------------STVMRNREDC------------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ----------------ELTALN-------------------------------------- CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP RVTSVY--------FKSLYSPSAEVKEAAHTGL---RMVLAHQNRL-------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP RIFGAL--------YKAINSNSVELQNAGKEAM---RKFMSDTSQS-------------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -------------------SADSKSKEES------------------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP -------------------TTENNKRATS------------------------------- GK009_Glam_PIKK-Unclassified --------------------SFSRDVLHR------------------------------- TRRAP_Hsap_TRRAP -------EVDQI---------HTHMRPLL----------MMLG----------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR -------WNWYKRDALDLTVRLALNVYLL----------DGVR----------------- CG2905_Dmel_TRRAP -------EKEKV---------QSAMRPLL----------LKLG----------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR -------FSQYK---------KPICQFLV----------ESLH----------------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP -------ETPEI---------AEKLHPSL----------LKVSPISTIIIATFGASYIRN B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ----------------------NIMNSISSYMAQVSYKNQSII----------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR -------FSQYK---------KPICQFLV----------ESLH----------------- DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP -------EVDQI---------HTHMRPLL----------MMLG----------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR KTLMMTNMAQYI---------N---PRII----------ENLY----------------- DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP -------HRDLL---------QTCLRPVL----------SNIT----------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -------EMELV---------HTSVRPLL----------LMLG----------------- CC1G_00839_Ccin_ATM -------NSEKE---------GFVGLLGY----------IRSQVADASILD--------- CC1G_08126_Ccin_ATR -------LSPHF---------DRVVKIVF----------ERLS----------------- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP -------PKELL---------QSGLRPIL----------MNLA----------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP -------DIELV---------HSALRPLL----------MMLG----------------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ---------DYRS-------LTLN------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ---------DHRN-------LSIP------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ---------SSQM-------TALPSAPCQSSEI--------------------------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ISGAGDDSDSDRH-------ISYN------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ---------FYEI-------KSLFGPPQQSIEKSAFYSLAMSMLSLVSYPSLVFSLEDMM MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ---------SSQM-------TALPNTPCQNADV--------------------------- DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ---------DYRS-------LTLN------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ---------TNR------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ---------DPKS-------LSVP------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ---------DHRT-------LNLN------------------------------------ CC1G_00839_Ccin_ATM ---------NPTTLAMDADDGGAW------------------------------------ CC1G_08126_Ccin_ATR ----------TQP----------------------------------------------- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ---------DPKR-------LTVS------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ---------DFRN-------LNPT------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP -------VVNRLTSVTRLFP---------------------------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ----FTR-------SLRALT---------------------------------------- CG2905_Dmel_TRRAP -------AIKRLSYFTQIFP---------------------------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK -----------------ELC---------------------------------------- ATR_Mmus_ATR RKQDVAHHREMALNTLSEIA---------------------------------------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP -------DIMKFKCLVELNP---------------------------------------- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM TYSGFNHTRAFIQQALNKITVAFRYQNLTELFEYCKFDLIMYWFNRTKVPTSKLEKEWDI MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR RKQDVAHQREMALNTLSEIA---------------------------------------- DNAPK_Hsap_DNAPK -----------------ELC---------------------------------------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP -------VVNRLTSVTRLFP---------------------------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR -------------QSLVELC---------------------------------------- DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP -------FLQGLSRLLELLS---------------------------------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -------VIQRLHSLTQLFP---------------------------------------- CC1G_00839_Ccin_ATM -------AVRTSETSTSKLP---------------------------------------- CC1G_08126_Ccin_ATR -------------TLLTELC---------------------------------------- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP -------GLEGLARVLSLLN---------------------------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP -------LLQRLTHMVELFP---------------------------------------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP N----------------------------------------------SFNDKFC-----D SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR KMLGFTCVQEFTCKYHRLLTAMVLPHCIVNP--L--CKGVLVLIAKQMQKHIGT-----L CG2905_Dmel_TRRAP Q----------------------------------------------MFNEKLS-----E CG6535_Dmel_ATM -NRTASWYSLSGESLF----KCLNFHIDPEMR--PSMDSRIQSMT-TLQTKHSR-----V CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK S-INLCS---SGARQE----RSKLLSILSAC--KQL---HKAGFSHVISPSQST-----A ATR_Mmus_ATR NVFDFPDLNRFLTRTL----QVLLPDLAAKA--SPAASALIRTLGKQLNVSRRE-----I ATM_Mmus_ATM -LLNYTSIEDFYRSCY----KILIPHLVIRS-----HFDEVKSIANQIQKCWKS-----L C47D12.1_Cele_TRRAP K----------------------------------------------ILVTKMA-----V B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM SLFGFADIHEFLGR-----YFVEISAIYFSQ--GF---NQ-------------------- MEC1_Scer_ATR ------------------------------------------------AGNDFK-----L ATM_Hsap_ATM -LLNYTNIEDFYRSCY----KVLIPHLVIRS-----HFDEVKSIANQIQEDWKS-----L ATR_Hsap_ATR NVFDFPDLNRFLTRTL----QVLLPDLAAKA--SPAASALIRTLGKQLNVNRRE-----I DNAPK_Hsap_DNAPK A-VNLYG---PDAQVD----RSRLAAVVSAC--KQL---HRAGLLHNILPSQST-----D TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP N----------------------------------------------SFNDKFC-----D smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR RYFLGIGLNQFLISSL----PTVIPVLIFKS--SNN---ILNCLKDELKDLKELCGQDYL DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP N----------------------------------------------CFNAALG-----E ATMa_Spur_ATM -VLGCSSSQEFLSKHH----TAIIPHLVNLK-----KLGTVKSIAGELKQDWKD-----L ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP N----------------------------------------------AFNEKLC-----E CC1G_00839_Ccin_ATM G----------------------------------------------EKNQELC-----R CC1G_08126_Ccin_ATR R-LMQLNIEEFISRHH----AKALPDVLLRC--DMK---GVDLIAHSLGKNRST-----T CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP N----------------------------------------------YFKVEIG-----H AqueK043_Aque_ATM -LLSLDNINEFYRKYY----RSVVPHILA-T-----DRDSLQSISDATLLSKED-----L AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP T----------------------------------------------SFNEKMC-----E ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ---MKISTGDLLRKMI----PYVLPKLILDQQHDERAPQTLNTLAHLLQTSLPL-----V DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP Q----------------------------------------MMQHLRKWMEVVVITHKGG SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR F----------------------------------------SISFLRIYTH--------- CG2905_Dmel_TRRAP Q----------------------------------------ILQHCSKIMEIFVSEYKST CG6535_Dmel_ATM L----------------------------------------VDIFG----R--------- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK L-------------------------------------------NHSVGMRLLSLVYKGI ATR_Mmus_ATR L----------------------------------------INNFKYIFSH--------- ATM_Mmus_ATM L----------------------------------------VDCFPKILVH--------- C47D12.1_Cele_TRRAP NLANQMVKYKMSDKISRILSVPSSFTEEELDDFEAEKMKGIRELD--------------- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM LIIFPLIDVIYKYET--------------------------------------------- atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR I----------------------------------------LNEASVSIQ---------- ATM_Hsap_ATM L----------------------------------------TDCFPKILVN--------- ATR_Hsap_ATR L----------------------------------------INNFKYIFSH--------- DNAPK_Hsap_DNAPK L-------------------------------------------HHSVGTELLSLVYKGI TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP Q----------------------------------------MMQHLRKWMEVVVITHKGG smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR M----------------------------------------GLIFEYIFIH--------- DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP K----------------------------------------LFEYLKKFEEAGKLSYLAN ATMa_Spur_ATM L----------------------------------------KSSFPRTIAS--------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP Q----------------------------------------MLGHLKKWLETTVISQKNG CC1G_00839_Ccin_ATM ----------------------------------------LVEGQLIFTIRVAALSSLLG CC1G_08126_Ccin_ATR I----------------------------------------LDSLDKILVP--------- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP K----------------------------------------LLEHFRVVADPQSLQATAR AqueK043_Aque_ATM I----------------------------------------KESLPVTMAS--------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP S----------------------------------------LLAHLKRWVEVIVNNSQSK ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR L----------------------------------------LEWCHKVLSV--------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP QRSDGNESISECGRCPLSPFCQFEEMKICSAIINLFHLI------------PAAPQTLVK SMG1_Hsap_SMG1 --------------------------------ALRSHMS--------------------- FRAP_Hsap_FRAP -------------------------------------------------------ARMLG mei-41_Dmel_ATR -----------------------------------VFLT------------EEPELA--- CG2905_Dmel_TRRAP SPNVNFFAS----------SKGGEYEQKIVILIEMFFYI------------SAS-VKYIE CG6535_Dmel_ATM -----------------------------------LKTNC-------------------- CG4549_Dmel_SMG1 --------------------------------QLPLHLT--------------------- FRAP_Mmus_FRAP -------------------------------------------------------ARMLG DNAPK_Mmus_DNAPK VPAEERQCL--------------------------------------------------- ATR_Mmus_ATR -----------------------------------LVCS------------CSKDEL--- ATM_Mmus_ATM -----------------------------------ILPYFAYEGTRDSYVSQ-------- C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP -------------------------------------------------------AKMIA atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM -----------------------------------ILPYFAYEGTRDSGMAQ-------- ATR_Hsap_ATR -----------------------------------LVCS------------CSKDEL--- DNAPK_Hsap_DNAPK APGDERQCL--------------------------------------------------- TOR_Dmel_FRAP -------------------------------------------------------AKMLD SMG1_Mmus_SMG1 --------------------------------ALRSHMS--------------------- TRRAP_Mmus_TRRAP QRSDGNESLSECGRCSLSPFCQFEEMKICSAIINLFHLI------------PAAPQTLVK smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP -------------------------------------------------------ASLLC TOR2_Scer_FRAP -------------------------------------------------------ATLLC TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR -----------------------------------A---------------TSVENL--- DNAPK_Ddis_DNAPK -SNNNNNSSSSGNNKSMFSLIDIRQLINTEGTDRLIHLI------------HS-YQILYK SMG1_Ddis_SMG1 --------------------------------PYKLLIM--------------------- Tor_Ddis_FRAP -------------------------------------------------------ARLLG TRRAP_Ddis_TRRAP K------------------YRDSEEVKICASIIDIFHLL------------PPA-AKLLD ATMa_Spur_ATM -----------------------------------LLPLLAQSREHSERAEE-------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -------------------QKSTDSLKICTAILNIFHAI------------PAASAKILE CC1G_00839_Ccin_ATM DSSD-------------------VKDFQQFLNGLLNSVE------------ESAPWCLLV CC1G_08126_Ccin_ATR -----------------------------------ILLL------------PTVPQT--- CC1G_00894_Ccin_FRAP -------------------------------------------------------TRLLT CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP L-----------------PFSETEGVPKLVRLANIFHLL------------PSAANVFLD AqueK043_Aque_ATM -----------------------------------ILKAMAHSDGDEDSKRQ-------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------PVRRGEEVQVCILILDMFHML------------PASSFKLFD ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR -----------------------------------LLLR------------ADGREL--- DNAPK_Smoe_DNAPK -------------RTLSMDASVGPQLAV-------------------------------- FRAP_Smoe_FRAP -------------------------------------------------------AILLG SMG1_Smoe_SMG1 --------------------------------KEEGNFV------------TKR------ GK008_Glam_FRAP -------------------------------------------------------NELIV GK009_Glam_PIKK-Unclassified -------------------------------------------------------VQLLH TRRAP_Hsap_TRRAP -P----------------LLEVVMKTERAMLIE-------------------------AG SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP -H----------------LVSN--------APR-------------------------LI mei-41_Dmel_ATR -------------------------------NS-------------------------CI CG2905_Dmel_TRRAP -K----------------LCQLVLKTEKNLMIE-------------------------AS CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP -H----------------LVSN--------APR-------------------------LI DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR -------------------------------ER-------------------------AL ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ---------------------MIGHTVKMLAG---------------------------- B0261.2_Cele_FRAP -Q----------------LAKQ--------SPK-------------------------FM atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------DIRIVMIQRKSL-----------------------------I TEL1_Scer_ATM --------------------------------KWILDMLHAITGNGDAYLVDNSYYLCIP MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR -------------------------------ER-------------------------AL DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP -H----------------LVIS--------TPR-------------------------LI SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP -P----------------LLEVVMKTERAMLIE-------------------------AG smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP -T----------------LIRS--------SKD-------------------------VA TOR2_Scer_FRAP -T----------------LINS--------SDE-------------------------VA TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR -------------------------------TS-------------------------CI DNAPK_Ddis_DNAPK YN----------------LLDS-------ILLE-------------------------NY SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP -H----------------LISA--------SEK-------------------------LI TRRAP_Ddis_TRRAP -S----------------TIILTIRLEQSLCKE-------------------------VT ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -H----------------LLTLVIKAEGALTME-------------------------VG CC1G_00839_Ccin_ATM VPILLREIDIGSLKVNEDIALSLLNAIARCLK---------------------------- CC1G_08126_Ccin_ATR -------------------------------NK-------------------------AV CC1G_00894_Ccin_FRAP -L----------------LVSA--------TQR-------------------------LI CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP -P----------------LVNLIIQTETQMHFS-------------------------TV AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP -P----------------LISLCIKAEKALGTE-------------------------LS ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR -------------------------------MA-------------------------AL DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -S----------------LIRA--------CET-------------------------LI SMG1_Smoe_SMG1 -------------------------------PL-------------------------ER GK008_Glam_FRAP -K----------------IFKF--------CGS-------------------------IV GK009_Glam_PIKK-Unclassified -T----------------LVSS--------KKK-------------------------GS TRRAP_Hsap_TRRAP S---PF-------------------------REPLIK----------------------- SMG1_Hsap_SMG1 ----------------------------------K------------------------- FRAP_Hsap_FRAP R---PY-------------------------MEPILK----------------------- mei-41_Dmel_ATR E---LV--------------------------------VSCTQS---------------- CG2905_Dmel_TRRAP S---PY-------------------------REALIK----------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ----------------------------------L------------------------- FRAP_Mmus_FRAP R---PY-------------------------MEPILK----------------------- DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR H---YL--------------------------------KNETEI---------------- ATM_Mmus_ATM --------------------------------------KRETATKVYDTLKG-EDFLGK- C47D12.1_Cele_TRRAP CPVTTF-------------------------TEQIIV----------------------- B0261.2_Cele_FRAP R---PY-------------------------VGSLMI----------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR T---ET-------------------------FAQLVQ----------------------- TEL1_Scer_ATM L---AF--------------------------------ISGGVN---------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM --------------------------------------QRETATKVYDMLKS-ENLLGK- ATR_Hsap_ATR H---YL--------------------------------KNETEI---------------- DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP S---SY-------------------------MNPILK----------------------- SMG1_Mmus_SMG1 ----------------------------------K------------------------- TRRAP_Mmus_TRRAP S---PF-------------------------REPLIK----------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP K---PY-------------------------IEPLLN----------------------- TOR2_Scer_FRAP K---PY-------------------------IDPILD----------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR I---CF--------------------------------CRFADF---------------- DNAPK_Ddis_DNAPK N---EQ-------------------------SEQ-------------------------- SMG1_Ddis_SMG1 ----------------------------------G------------------------- Tor_Ddis_FRAP K---PY-------------------------VEPILK----------------------- TRRAP_Ddis_TRRAP S---PY-------------------------REPLIR----------------------- ATMa_Spur_ATM --------------------------------------EKERAAWAVQCLEELKQAIGQE ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP S---PF-------------------------REPLLK----------------------- CC1G_00839_Ccin_ATM TYNHSY-------------------------NTEMRC----------------------- CC1G_08126_Ccin_ATR A---FL-------------------------IGIFNEDSRDAKI---------------- CC1G_00894_Ccin_FRAP K---PY-------------------------AIPMLR----------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP N---PF-------------------------SEPLAK----------------------- AqueK043_Aque_ATM --------------------------------------AKDTNEYILSVIS-------KE AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP S---PF-------------------------REPLLK----------------------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR H---FY--------------------------------EAQTGS---------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP T---PY-------------------------VIPIHK----------------------- SMG1_Smoe_SMG1 E---KH-------------------------WRSV------------------------- GK008_Glam_FRAP L---PY-------------------------VPMVYS----------------------- GK009_Glam_PIKK-Unclassified A---PAEMPISIFANLSNYTGFLFRITSLCHMKPLLG----------------------- TRRAP_Hsap_TRRAP ----FLTRHPSQTVELFM--MEATLNDP-------------------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ----ALILK--------------------------------------------------- mei-41_Dmel_ATR SLQQLMNADVKQTVAELLIYF--NRN-P-------------------------------- CG2905_Dmel_TRRAP ----FLQRFPTETVDLFL--TESLMIDP-------------------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ----ALILK--------------------------------------------------- DNAPK_Mmus_DNAPK ----------------------------QSLDPSCKSLANGLLELAFGFGGLCDHLVSLL ATR_Mmus_ATR ELGSLLRQDFQGLHNELLLRI--GEH-Y-------------------------------- ATM_Mmus_ATM QIDQ-------------------------------------------------------- C47D12.1_Cele_TRRAP ----DISRFAAHFE---------------------------------------------- B0261.2_Cele_FRAP ----AMIPK--------------------------------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ----FL-----------A--FENNRNTT-------------------------------- TEL1_Scer_ATM ELIFDILPQISG------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM QIDH-------------------------------------------------------- ATR_Hsap_ATR ELGSLLRQDFQGLHNELLLRI--GEH-Y-------------------------------- DNAPK_Hsap_DNAPK ----------------------------PSLDLSCKQLASGLLELAFAFGGLCERLVSLL TOR_Dmel_FRAP ----ALVPK--------------------------------------------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ----FLTRHPSQTVELFM--MEATLNDP-------------------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ----VLLPK--------------------------------------------------- TOR2_Scer_FRAP ----VILPK--------------------------------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR NQDAVVSNLPKSFINSLILNL--ANGDG-------------------------------- DNAPK_Ddis_DNAPK -GIQDLPKSSLE-FSEFIFDY--LFNNCENLSPSKLLISKELIQLALTIGIKPIKLLSLI SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ----ALLPK--------------------------------------------------- TRRAP_Ddis_TRRAP ----FLAKYPQRTIEIFM--GQ----LP-------------------------------- ATMa_Spur_ATM TLNA-------------------------------------------------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ----YLLRYAQQTVDLFL--QENNLKNH-------------------------------- CC1G_00839_Ccin_ATM ----LATRALASTF---------------------------------------------- CC1G_08126_Ccin_ATR SLQTILPGHTTSVLTELVIRM--GVDDP-------------------------------- CC1G_00894_Ccin_FRAP ----VLLQK--------------------------------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ----MLLQR--------------------------------------------------- CC1G_00331_Ccin_TRRAP ----YLDRYPVEGIDFLV--R--NLQLP-------------------------------- AqueK043_Aque_ATM TLNT-------------------------------------------------------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ----FTLRFTSLSMEFFL--S--HLSDI-------------------------------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR DAREIFAAVLPALLDELVWFL--GDTSN-------------------------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ----ALVAR--------------------------------------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ----AVMGL--------------------------------------------------- GK009_Glam_PIKK-Unclassified ----SICYR--------------------------------------------------- TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK LNSAMLSTQYLGSSQR----------------------NISFSHGEYFYSLFSEVINSEL ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK LNPAVLSTASLGSSQG---------------------SVIHFSHGEYFYSLFSETINTEL TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK INPNVQNTTTTTTT-TSTTTTTTTTTTSTNNNNDNNNEFIKDIHDIFYKTLFTE-INNYI SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ----------------QWSRMF-----------M-SFLKH--K----------DA-RPLR SMG1_Hsap_SMG1 ---------------------------------------A--PSNT-FH----------- FRAP_Hsap_FRAP -------------------------------------------------LKDPDP-DP-- mei-41_Dmel_ATR -------------------TFVMR--------SFQ------------------------- CG2905_Dmel_TRRAP ----------------QWNRLF-----------I-YLLKH--E----------TG-VSFR CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ---------------------------------------T--GGES-SM----------- FRAP_Mmus_FRAP -------------------------------------------------LKDPDP-DP-- DNAPK_Mmus_DNAPK LKNLDIAVSRLMESSSDNPKMV-----------ST------------------------- ATR_Mmus_ATR -------------------QQVFN--------GLS------------------------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP -------------------------------------------------LRNDQ---K-- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ----------------SFWKFC-----------S-DHCDFKDE--------------DIR TEL1_Scer_ATM -----------------------KTTVKYHKKYRL------------------------- MEC1_Scer_ATR -----------------------------------TCFKT----------------NNIT ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR -------------------QQVFN--------GLS------------------------- DNAPK_Hsap_DNAPK LKNLDLAVLELMQSSVDNTKMV-----------SA------------------------- TOR_Dmel_FRAP -------------------------------------------------LHEPE---S-- SMG1_Mmus_SMG1 ---------------------------------------A--PSNT-FH----------- TRRAP_Mmus_TRRAP ----------------QWSRMF-----------M-SFLKH--K----------DA-RPLR smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP -------------------------------------------------FQDT------- TOR2_Scer_FRAP -------------------------------------------------CQDA------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR -------------------QQAK-K-------ALD------------------------- DNAPK_Ddis_DNAPK SNNFQLF-LPLLANRIIETNQI-----------HK------------------------- SMG1_Ddis_SMG1 ---------------------------------------S--TSQPFFN----------- Tor_Ddis_FRAP -------------------------------------------------LRDS------- TRRAP_Ddis_TRRAP ----------------QFNLIF-----------R-LILKH--Q---------PLS-KP-- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ----------------QLSRMF-----------N-YLLKH--E----------LA-EPLR CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ----------------QSRHQA-----------LNAV----------------------- CC1G_00894_Ccin_FRAP -------------------------------------------------ANDP------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K -------------------------------------------------LRSA------- CC1G_00331_Ccin_TRRAP ----------------RTVRTF-----------R-SALQA--K----------VS-PNLE AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ----------------TISRIL-----------Q-YFLKH--K----------DG-KPLK ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR -------------------DEAV-KRSARVGPMIQ------------------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -------------------------------------------------LSEGSGGSG-- SMG1_Smoe_SMG1 ---------------------------------------L--SANR-FALQLS------- GK008_Glam_FRAP -------------------------------------------------ISKDC--D--- GK009_Glam_PIKK-Unclassified ---------------------------------------E-------------------- TRRAP_Hsap_TRRAP DVL--AAN-------PNR-FIT--------L-LLPGGAQTAVRPGSPSTSTMRLDLQFQ- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP -------NPGVINNVLATI----------------------------------------- mei-41_Dmel_ATR ------S--------LLQ-LSIG--SLEELSSQTA----------------NAEFANFI- CG2905_Dmel_TRRAP AVI--KSSR------YNN-LIH--------Y-LNT-HT--------EFPEALKYEIQHQ- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP -------NPGVINNVLATI----------------------------------------- DNAPK_Mmus_DNAPK --------------------------------VLNGMLDTSFR--------DRAVQKHQ- ATR_Mmus_ATR ------I--------LAS-FASSDDPYQGPRDITS----------------PELMADYL- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP -------YAEVTAQVLNAV----------------------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR TVI--SSY-------RKQVFMH----------LLLVSAREFLNPRNPSMIVEQLRATYE- TEL1_Scer_ATM ------L--------MLKWIIRFTDLG--------------------------------- MEC1_Scer_ATR RLTSWTV--------ILG-RL---------------------A--------CLESEKFSG ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------I--------LAS-FASSDDPYQGPRDIIS----------------PELMADYL- DNAPK_Hsap_DNAPK --------------------------------VLNGMLDQSFR--------ERANQKHQ- TOR_Dmel_FRAP -------NPGVILNVLRTI----------------------------------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP DVL--AAN-------PNR-FIT--------L-LLPGGAQTAVRPGSPSTSNMRLDLQFQ- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP -------SSTVASTALRTI----------------------------------------- TOR2_Scer_FRAP -------SSAVASTALKVL----------------------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------Y--------VSQ-F------------VGG----------------DMTFDKFL- DNAPK_Ddis_DNAPK --------------------------------VLN---DVCIM--------KQQQQPNR- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP -------NPRVASCVLAAL----------------------------------------- TRRAP_Ddis_TRRAP --------IVEELANTYSIWLE--------A-HLK----------SPS-----ADIRFH- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP SAI--QKN-------PSK-LIN--------L-AFSK-SQPPARP-TNTAEKFLLELQYQ- CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ----------------KK-VETA--LQKGTI-SIS-------Q--------KANPSEFL- CC1G_00894_Ccin_FRAP -------NPAVAANVLMCL----------------------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K -------EPTVEAAIAYNL----------------------------------------- CC1G_00331_Ccin_TRRAP REL--VS--------RTP-ILA--------P-RLS-------G--------GADQNQMR- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP EHL--YSN-------PQK-LID--------A-TFR---QPAAGT-DDASIQKKAELQYQ- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------E--------VAR-I------------ISG----------------SDDLPSFL- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -------NIGVVSGVMATV----------------------------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP -------DEYLLITSLTTL----------------------------------------- GK009_Glam_PIKK-Unclassified --------------------AYIDDEPKAPDVV--------------------------- TRRAP_Hsap_TRRAP -----------------------------------------A-IKIISII-VKN---DD- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------AERFLGV-ITY---FES- CG2905_Dmel_TRRAP -----------------------------------------A-VLIIFTL-MES---DD- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------GLKLATAI-LQNWRKCD- ATR_Mmus_ATR ------------------------------------------QPKLLGI-LAF---FNM- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ----------------------------------------------------------YA B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -----------------------------------------N-IK-------KG---EK- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR TLPNSTKDMDNWYVCHLCDIEKTGNPFVRINPNRPEAAGKSE-------IFRI---LHS- ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------QPKLLGI-LAF---FNM- DNAPK_Hsap_DNAPK ------------------------------------------GLKLATTI-LQHWKKCD- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP -----------------------------------------A-IKIISII-VKN---DD- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------IKEFLGS-MNF---FTM- DNAPK_Ddis_DNAPK ------------------------------------------GFKDIIES-IVLFLNSI- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP -----------------------------------------T-LSMVSII-RKQ---LP- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -----------------------------------------S-IRICATM-VKH---DK- CC1G_00839_Ccin_ATM ----------------------------------------------------------DL CC1G_08126_Ccin_ATR ------------------------------------------ATQMLGI-MSK---IID- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP -----------------------------------------AILEIIDDL--I---TLE- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP -----------------------------------------G-ISLFHFL-LEE---RE- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------RQHFVRL-LNN---IDR- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP YSQD-KLIDLDDEENKDEDERKIWDRDMF------------------------------- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM WLTSQT----------------------QHVSPKAAQLCSWIATSLGNSRFDSWVMRDAC CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP -------------------------------------------------AFSIVDRISKS B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM VQFLCRYLSVSGRRSSWPFKGTGEEPTPTSILEKLTTDPDVRVRFRVATAIPMLFAVSRT CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP --SWLA----S-----QH-----------SLVSQLRRVWVSEN--FQE------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR --CLSE----------PSFEK--PL----------------------------------- CG2905_Dmel_TRRAP --QWIP----T-----RQ-----------DIVDALKNCWQN----YLS------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK --SWWA----PD-----S--APESKTTVLSLLAKMLQIDSALS--FDTNHSSFSEIFTTY ATR_Mmus_ATR --QLLS----------SSVGI--ED----------------------------------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP CPEWLI----S-----PN-----------SPIPRIKKLFSETE--FNE------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR --FMISTAIET-----R------------------------------------------- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR --NFLS----HPNIDEFSESLLSG------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR --QLLS----------SSVGI--ED----------------------------------- DNAPK_Hsap_DNAPK --SWWA----KD-----S--PLETKMAVLALLAKILQIDSSVS--FNTSHGSFPEVFTTY TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP --AWLA----S-----QH-----------SLVSQLRRVWVSET--FQE------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR --IMTN----------KQKST--QE----------------------------------- DNAPK_Ddis_DNAPK --SEWT----LN-----SNLKLVEKENIIEFTKNLIKIDPIQF--FENKHC-YEFVYNII SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP --NWLP----E-----NR-----------KVLDILIEYWRPLSHMIQS------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK -------------------------------------IDFKFA--TDPTHLAFCPVFNQY FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP --EWLP----Q-----TP-----------TVFVHLRRIWVSDA--FQE------------ CC1G_00839_Ccin_ATM DNHKLP----S-----L------------------------------------------- CC1G_08126_Ccin_ATR --TLQD----VH----GKKSV--E------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP --PTFL----SQ----HAYVT--D------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP --EWIK----D-----KG-----------EVIKHLKAIWLSDS--YHS------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR --KLLR----------S-EDV--QM----------------------------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ---------------------------------RHR---------------KENMAATNW SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR -------------------KEETLYSLGQ--IM--------------------------- CG2905_Dmel_TRRAP ---------------------------------TLS---------------SEDVLCDLW CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ASLLADTKLGLHLKGQAII----------------------------------------- ATR_Mmus_ATR -------------------KKMALTSLMS--LM--------------------------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ---------------------------------RYVVRALTEVKKFQEEIIVKRMTEHKY B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------ILFSLHRIFSHFQPPKLT---------------DGNGQINKS ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR -------------------KKMALNSLMS--LM--------------------------- DNAPK_Hsap_DNAPK ISLLADTKLDLHLKGQAVT----------------------------------------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ---------------------------------RHR---------------KENMAATNW smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR -------------------KLTMMTSFHR--LL--------------------------- DNAPK_Ddis_DNAPK TNYLCR-SNPLTFKNKVLV----------------------------------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ---------------------------------ASN---------------PLDISNQTL ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK LSMLRDPKKPLAWKTQVLD----------------------------------------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ---------------------------------RHR---------------HDNQGVSHW CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------AKEQIIRSIGV--FI--------------------------- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------QLVAVWRSLGL--TPNDG---------------NDKAEITYW AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ---------------------------------LIT---------------KDAVPLSHW ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR -------------------QKQALRCIER--LL--------------------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ---------------------------------------------------------ALW TRRAP_Hsap_TRRAP KEPKLLAYCLLNYCKRNYGDIELLFQLLRAFTGRFLCNMTFLKEYMEEEIPKN------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP -----------------------------------------------G------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ---HLIGKILLHYFSNNTNDIELLFQLLRALCFRFIPDVYFLRDFLQHTVAQS------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP -----------------------------------------------G------------ DNAPK_Mmus_DNAPK ----LLPFFTSLR--E--------------------GSLENLKHILEKLIVCNFPMKSDE ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP KVPKLILNTFLRYLRLNIYDYDLFIVIASCFNGNFVTDLSFLREYLETEVIPK------- B0261.2_Cele_FRAP -----------------------------------------------S------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -----------------NEGIEFLFIFRTYFT---------------------------- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR F--KLVQKCFMN------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ----LLPFFTSLT--G--------------------GSLEELRRVLEQLIVAHFPMQSRE TOR_Dmel_FRAP -----------------------------------------------G------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP KEPKLLAFCLLNYCKRNYGDIELLFQLLRAFTGRFLCNMTFLKEYMEEEIPKN------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP -----------------------------------------------G------------ TOR2_Scer_FRAP -----------------------------------------------G------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ----LLPYLLSYPK-H--------------------NNFDLIKQKLNEIVVYDFPLNSKD SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP -----------------------------------------------G------------ TRRAP_Ddis_TRRAP RETKIIVKCFLQYCKAHSEETDLYFYMLSVLTLRASMDFNFLRDYYQH------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ----VLYFFANVP--E--------------------KEEKELKSALDLLVANHFPLKSTD FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP EEPKLLVKCLLNYAKQHPSNVELLFQLLRVFSNRYLPNFQFFRTFLEETVAQG------- CC1G_00839_Ccin_ATM -----------------------YNEMKDAFSADVDHHCQVLQKDIETGIDQC------- CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP -----------------------------------------------G------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K -----------------------------------------------V------------ CC1G_00331_Ccin_TRRAP H--SIIQSSFIKAM-KQTPRIDLLFELIAIYSRNLEIDTVKTTTFLYQHVALS------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP QECSMLVNCLLLYCKYHKDDIETLFYLLKVFMFRHVTSFPFLKSYLENEVAKQ------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -----------------------------------------------G------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP -----------------------------------------------A------------ GK009_Glam_PIKK-Unclassified NRLKVMYL---------------------------------------------------- TRRAP_Hsap_TRRAP -------------------------------YSIAQKRALFFRFVD-FNDPN--FG---- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP -------------------------------FTVNWKRNAFFYFVENFNNSF--LS---- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK FPPDSLKYNNYVDCMKKFLDALELSQSPMLFQLM-------------------------- ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP -------------------------------VPLQWRRELFLRIMQKFDTDPQTAG---- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK FPPGTPRFNNYVDCMKKFLDALELSQSPMLLELM-------------------------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP -------------------------------YSIAQKRALFFRFVE-FNDPN--FG---- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK LTVKSPIYNEYITCIERLLETFELTKNPLVIDTL-------------------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK LDAGSPRYNDYIMALNKILTSLVMSGSLMLLKLI-------------------------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -------------------------------YSVEQKRHIFFKFVELFHDKS--FP---- CC1G_00839_Ccin_ATM -------------------------------FGDIVGFHVVVYFFEH--DNPNE-AAMVG CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP -------------------------------EDIIFRRNVLMRFLTWFNDSS--VP---- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP -------------------------------YTIEQKRAVFFKFVEIFSLSD--YL---- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ----------DELKAKV--------------------------------------LQHIL SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ----------------ELAQVSG--LEMRKWVDELFII---------------------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ----------EELKAKI--------------------------------------ITAVI CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ----------------ELAQVSG--LEMRKWVDELFII---------------------- DNAPK_Mmus_DNAPK ----------TDILCRE--------------------------------------QRHIM ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ----------TSMQ-----------------------------------HV--KALQYLV B0261.2_Cele_FRAP ----------------EIAVIGG--AEIVKNLKPLFEK---------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ----------TEVLCRE--------------------------------------QQHVM TOR_Dmel_FRAP ----------------DLAEVNGGSDEMELWADDLLSI---------------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ----------DELKAKV--------------------------------------LQHIL smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ----------------ELSVVGG--EDMKIYLKDLFPL---------------------- TOR2_Scer_FRAP ----------------ELSVVGG--KEMTRYLKELMPL---------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ----------LHVL-KE--------------------------------------TDHTH SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ----------------ELSVVGG--EEMVQHIDSLLPL---------------------- TRRAP_Ddis_TRRAP ----------------DLAPSST--IEQKKKIIQTFLIFFKDQTIPSDNKV--QAIQNLI ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ----------ISILCRD--------------------------------------EKHSY FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ----------QELKAKA--------------------------------------LQYVI CC1G_00839_Ccin_ATM GLATLLGREEDKLR-----------------------------------SDFSAHADAII CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ----------------ELACVAG--EDAMPHVQELMQI---------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ----------------DLALIAP--RNAFVDIVRVFSA---------------------- CC1G_00331_Ccin_TRRAP ----------LDTKGYF--------------------------------------IRYVV AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ----------QELKAKI--------------------------------------LQYIL ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ----------------ELARVAG--CAIRPHIKDLMPL---------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ----------------ELFTIGS--TSMVHCLAEVIPL---------------------- GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP NPAFLYSFEKGEGEQ-LLG-----------------PPNPEGDN---------PESITS- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ---------------RFVGSQHVT------------------QF---------RFKIIA- CG2905_Dmel_TRRAP IPCFAVSFDKGEGNK-LIGAPP----------------TPYQED---------EKNIVS- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK EELFQTTFKR-------------------------------------------------- ATR_Mmus_ATR ---------------KLMGPKHVS------------------SV---------RVKMMT- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP IPTLHWAFERYDTDE-IVG----------------TAPIDDSDSSMDVDPAGSSDNLVA- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ---------------------SLT------------------EL---------RST---- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ---------------KLMGPKHVS------------------SV---------RVKMMT- DNAPK_Hsap_DNAPK EELFQSSFRR-------------------------------------------------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP NPAFLYSFEKGEGEQ-LLG-----------------PPNPEGDN---------PESITS- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ---------------GLMGQ-SVD------------------LF---------RPKIMA- DNAPK_Ddis_DNAPK INYINLSIER-------------------------------------------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP TPILTNYFHQTDRNS-SSG----------------GGII--------------EDSLFI- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK EDKIQGALSS-------------------------------------------------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP IPMFAASFDKGEGDS-LIGGPPNPGQDSPDNPLIGGPPNPGQDS---------PDNLVS- CC1G_00839_Ccin_ATM ASMLRTMGDQDYTDN-GKI----------------I------------------------ CC1G_08126_Ccin_ATR ---------------SLVGP-PIH------------------SL---------SSQIMA- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP TPTLLVQANRSPTSDRLIN----L------------------DF---------ISQLHR- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP IPVFTFSFEEGERDE-LLGGPP----------------DPERDS---------DTNIIS- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ---------------EMIGS-HLS------------------AF---------IPKIMA- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified QVIIY--------------------------------------------------GIHTP TRRAP_Hsap_TRRAP ----------------------------------VFITKVL--DPEK------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ----------------------------------MLSFVHTLQEPRL------------- CG2905_Dmel_TRRAP ----------------------------------VFINKVF--DPDK------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK --------------------------------------------IAR------------- ATR_Mmus_ATR ----------------------------------TLRTGLRFK-DDF------------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP -----------------------------------RLTSVI--DSHR------------- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR --------------------------------------------NDQYFLTREATAESFR TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ----------------------------------TLRTGLRFK-DDF------------- DNAPK_Hsap_DNAPK --------------------------------------------IAR------------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ----------------------------------VFITKVL--DPEK------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ----------------------------------FLRLA--IK-TPM------------- DNAPK_Ddis_DNAPK --------------------------------------------SIL------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ----------------------------------QLTKQTL--ETEV------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK --------------------------------------------FAK------------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ----------------------------------VFISKVI--DPEN------------- CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ----------------------------------IFQTSLS--VAEL------------- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ----------------------------------IIWSPIT--ENDA------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ----------------------------------VFISKVI--NPDK------------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ----------------------------------LLSQP-----QDL------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified VILESLLDYFGIFFYAVSTLVPGFLYTQLAVDMFLTLEEVI--DTDQ------------- TRRAP_Hsap_TRRAP ------QADML--------------------DSL-RIYL--------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ----------------------------------I------------------------- mei-41_Dmel_ATR ------QRICL--------------------KIW-H------------------------ CG2905_Dmel_TRRAP ------QY--D--------------------DAV-RIAL--------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ----------------------------------I------------------------- DNAPK_Mmus_DNAPK ------QSPCVTQLNLLESVYTMFRKADLPSNVT-RQAF--------------------- ATR_Mmus_ATR ------PELCC--------------------RAW-D------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------NY-LS--------------------DGM-VIVF--------------------- B0261.2_Cele_FRAP ----------------------------------L------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ILLQNMKQDFF--------------------DTNWYI----------------------- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------PELCC--------------------RAW-D------------------------ DNAPK_Hsap_DNAPK ------RGSCVTQVGLLESVYEMFRKDDPRLSFT-RQSF--------------------- TOR_Dmel_FRAP ----------------------------------L------------------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------QADML--------------------DSL-RIYL--------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ----------------------------------I------------------------- TOR2_Scer_FRAP ----------------------------------I------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------EEIAI--------------------DAW-F------------------------ DNAPK_Ddis_DNAPK ------STNDIEAKEIFSHCFELFLN---HYDEL-KITL--------------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ----------------------------------I------------------------- TRRAP_Ddis_TRRAP ------KASYD--------------------DTLL------------------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------RLPSEKQSAAANIPFEIFKQDKRYSKEI-RKAA--------------------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------PYGTS--------------------DSV-RILL--------------------- CC1G_00839_Ccin_ATM ------------------------------------PALESVTGSDNLQEDSKHVAVFRV CC1G_08126_Ccin_ATR ------AEVTL--------------------ESW-H------------------------ CC1G_00894_Ccin_FRAP ----------------------------------I------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ----------------------------------I------------------------- CC1G_00331_Ccin_TRRAP ------FLGSE--------------------EYF-KIEI--------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------PFGSS--------------------DSV-CILL--------------------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------QYESL--------------------SVW-L------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ----------------------------------I------------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ----------------------------------L------------------------- GK009_Glam_PIKK-Unclassified ------NN------------------------SIFTIYW--------------------- TRRAP_Hsap_TRRAP -LQYATL----------------------------------------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP -MDMLQD----------------------------------------------------- mei-41_Dmel_ATR -IFLHVV----------------------------------------------------- CG2905_Dmel_TRRAP -LQLACL----------------------------------------------------- CG6535_Dmel_ATM ----------------------------------------------------YSASFSSQ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP -MDMLQD----------------------------------------------------- DNAPK_Mmus_DNAPK -V---------------------------------------------------------- ATR_Mmus_ATR -CFVRCL----------------------------------------------------- ATM_Mmus_ATM ------VFISNLPEIVVELLMTLHETADSADSDASQSATALCDFSGDLDPAPNPPYFPSH C47D12.1_Cele_TRRAP -YQLCTL----------------------------------------------------- B0261.2_Cele_FRAP -THMIND----------------------------------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------LFISNLPEIVVELLMTLHEPANSS---ASQ-STDLCDFSGDLDPAPNPPHFPSH ATR_Hsap_ATR -CFVRCL----------------------------------------------------- DNAPK_Hsap_DNAPK -V---------------------------------------------------------- TOR_Dmel_FRAP -LEMLGD----------------------------------------------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP -LQYATL----------------------------------------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP -IKTFQD----------------------------------------------------- TOR2_Scer_FRAP -INTFQD----------------------------------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR -TFIQLL----------------------------------------------------- DNAPK_Ddis_DNAPK -I---------------------------------------------------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP -IDTLQD----------------------------------------------------- TRRAP_Ddis_TRRAP -IELLQL----------------------------------------------------- ATMa_Spur_ATM ------WIQSHLHLIVVELLTMLYEPWTE----TS----QSSRFMTPSDPEPDPPFFTSY ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK -I---------------------------------------------------------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -LQFAAL----------------------------------------------------- CC1G_00839_Ccin_ATM LTRYRG------------------------------------------------------ CC1G_08126_Ccin_ATR -EYLVTI----------------------------------------------------- CC1G_00894_Ccin_FRAP -LAKLAD----------------------------------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K -NRSANP----------------------------------------------------- CC1G_00331_Ccin_TRRAP -LNLTTV----------------------------------------------------- AqueK043_Aque_ATM ------SLKHSLPLLVVELLTRLYVPANS----DS----ALAQYSNVCDPEPIPPHHSLS AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP -LQFSSL----------------------------------------------------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR -SFVKRL----------------------------------------------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -VDALRD----------------------------------------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP -ITCIKE----------------------------------------------------- GK009_Glam_PIKK-Unclassified -L---GY----------------------------------------------------- TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ALH-------------------------------DFFLYCEVADAV---YDAARKNETIV CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM VIQATFAYISNCHKT-KFKSILEILSKIPDSYQKILLAICEQAAETNNVFKKHRILKIYH C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM VIKATFAYISNCHKT-KLKSILEILSKSPDSYQKILLAICEQAAETNNVYKKHRILKIYH ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM MIKATLDHLTTCHAGGRSLTLISLLAKTHDSIQKVLLELHLRMWRCRQPYERRRLLLGYR ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM AISTTLQYLPSCFSS-STDSFISVLAKQKEALQTIALHLNLRIFSTHRVFERKRLLISYS AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM TQCSFFVR-------DIWFFVVRLLIHTKFIRVQMAA------LT--------------- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM LFVSLLLKDIQSGLGGAWAFVLRDVIYTLIHYINK-RS-----SHFTDVSLRSFSLCCDL C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM LFVSLLLKDIKSGLGGAWAFVLRDVIYTLIHYINQ-RP-----SCIMDVSLRSFSLCCDL ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM LFGLLLIKELHTKLGGSWVYVLQNLIYTLVHTIHQ-HRAGEGRSSVMEGSSSLVLPCLDL ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM YFSSLVSRELTSGLHGSLPYMVMDIIYSVGRVMHH-HG-----N---DE--SISLICCDT AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP --------L---V-------EHAPHHIHDN--N-KNRNSKLRR------------LM--T SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP --------SSLLA----------------------------------------------- mei-41_Dmel_ATR --------N---V-------QELGPSLGRI----------V-A------------TL--Q CG2905_Dmel_TRRAP --------L---V-------ERASQHIHDGDANNKRQGNKLRR------------LM--T CG6535_Dmel_ATM -------FLELLLNKHNFRLDDYQNHFGDI----------A-K------------LLSNF CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP --------SSLLA----------------------------------------------- DNAPK_Mmus_DNAPK ----------------------------------------DRS------------LL--T ATR_Mmus_ATR --------D---H-------AYLGPLLSHV----------I-V------------AL--L ATM_Mmus_ATM LSRVCHTAVTQC-------KDALESHLHVI----------V-G------------TL--I C47D12.1_Cele_TRRAP --------F---V-------QNASEHIHN--NNCKKQGGRLRI------------LM--L B0261.2_Cele_FRAP --------SSSLH----------------------------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------ILMTLRQIPLNLDST--Q TEL1_Scer_ATM ----------------------------------------V-E------------KL--F MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM LSQVCQTAVTYC-------KDALENHLHVI----------V-G------------TL--I ATR_Hsap_ATR --------D---H-------ACLGSLLSHV----------I-V------------AL--L DNAPK_Hsap_DNAPK ----------------------------------------DRS------------LL--T TOR_Dmel_FRAP --------AGSPD----------------------------------------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP --------L---V-------EHAPHHIHDN--N-KNRNSKLRR------------LM--T smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP --------QSNSF----------------------------------------------- TOR2_Scer_FRAP --------QSNSF----------------------------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR --------K---L-------DSIGPILNQI----------V-F------------SI--L DNAPK_Ddis_DNAPK ----------------------------------------DKF------------CV--P SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP --------QSSTS----------------------------------------------- TRRAP_Ddis_TRRAP --------ETLLV----------------------------------------------- ATMa_Spur_ATM LRHISEAAVVQC-------SEEFSKHIEVI----------L-G------------AV--V ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ----------------------------------------QRV------------CI--P FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP --------L---V-------ERAAPHIHDA--ADKKQGTKLRR------------LM--T CC1G_00839_Ccin_ATM --------L---E-------TFTPH-EPN--SPALPTSCI---------------LR--G CC1G_08126_Ccin_ATR --------D---S-------KDLGPHLGST----------C-S------------AF--V CC1G_00894_Ccin_FRAP --------PQT-L----------------------------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K --------HKLPA----------------------------------------------- CC1G_13883_Ccin_PI4K --------DDPRF----------------------------------------------- CC1G_00331_Ccin_TRRAP --------L---V-------QYYSDLLDDV----------KKD------------II--R AqueK043_Aque_ATM LTNVTKAAIEKC-------PEVIGRHCHMI----------I-N------------TL--L AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP --------L---V-------EHAAPHIHDS--NNKKQGAKLRR------------LM--T ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR --------AQVSP-------ANLKTVASQI----------V-V------------AL--M DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP --------TSAAS----------------------------------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP --------ETSKT----------------------------------------------- GK009_Glam_PIKK-Unclassified --------IRLLL-------EH-------------------------------------- TRRAP_Hsap_TRRAP ---------FAWPCLLSKA-----CVD---------------------------PA---- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP --------------KRQVALWTLGQLVASTGYVVEP-------------------YRKYP mei-41_Dmel_ATR PL------LA-------------------------------------------------- CG2905_Dmel_TRRAP ---------FAWPCLLSKS-----SVD---------------------------PT---- CG6535_Dmel_ATM QL------CC-------------------------------------------------- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP --------------KRQVALWTLGQLVASTGYVVEP-------------------YRKYP DNAPK_Mmus_DNAPK ---------LLWHCDLDTLKEFFSRIVVDAIDVLKSRFTKLNE--FTFDTQITKKM---- ATR_Mmus_ATR PL------IH-------------------------------------------------- ATM_Mmus_ATM PL------VD-------------------------------------------------- C47D12.1_Cele_TRRAP ---------FAWPCLTMYN-----HQD---------------------------PT---- B0261.2_Cele_FRAP --------------KREAALRAIGGICRSTAYVVDP-------------------YRDYP atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ---------SSWISFIE------------------------------------------- TEL1_Scer_ATM PTSYLSPYLF-------------------------------------------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM PL------VY-------------------------------------------------- ATR_Hsap_ATR PL------IH-------------------------------------------------- DNAPK_Hsap_DNAPK ---------LLWHCSLDALREFFSTIVVDAIDVLKSRFTKLNE--STFDTQITKKM---- TOR_Dmel_FRAP --------------KRGVALWTLGQLISATGRVVTP-------------------YHKYP SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ---------FAWPCLLSKA-----CVD---------------------------PA---- smg-1_Cele_SMG1 -------------------------------------------------------KK--T TOR1_Scer_FRAP --------------KREAALKALGQLAASSGYVIDP-------------------LLDYP TOR2_Scer_FRAP --------------KRDAALTTLGQLAASSGYVVGP-------------------LLDYP TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR PF------VQ-------------------------------------------------- DNAPK_Ddis_DNAPK ---------LISHMKENILVQIFSQHLSSLMSIIQPLQPKYLSDSQERKSSIIEKI---- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP --------------KREVALKTLAQLASSTGYVIKP-------------------FSKYP TRRAP_Ddis_TRRAP --------------KNLS-------------SVLVD-------------------CR--K ATMa_Spur_ATM PL------VG-------------------------------------------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ---------LLRQASRDATVTFYKGHIHDIISVLEARLTKNPV--PAFENQLVSKI---- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ---------FAWPCLIQKN-----CVD---------------------------PT---- CC1G_00839_Ccin_ATM ---------LAWMETVPQA-----CRK---------------------------AT---- CC1G_08126_Ccin_ATR ---------SAWPNLSD-------R----------------------------------- CC1G_00894_Ccin_FRAP --------------KRDAALHALGQVCSSTGYVVQP-------------------LLDHP CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K --------------EV-------------------------------------------- CC1G_13883_Ccin_PI4K --------------SNNMVLAAQ-------TRLAQE-------------------LHRRP CC1G_00331_Ccin_TRRAP ---------CAWAPIQN-------NDD---------------------------VL---- AqueK043_Aque_ATM PL------TQ-------------------------------------------------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ---------FAWPCLLPKQ-----CVD---------------------------PA---- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR PC------LE-------------------------------------------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP --------------KRDVAVRTLGQLVQNTGYVVTP-------------------YTEFP SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP --------------LRLTTTRCFVRIVEATSFVVFP-------------------WFIYH GK009_Glam_PIKK-Unclassified -----------------------------SGETLT------------------------- TRRAP_Hsap_TRRAP ------------------CKYSGHLLLAHIIAKFAIH------KK--IVLQVFHSLLKAH SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP TLLEVLLN-FLK-TEQNQGTRREAIRVLGLL----------------------------- mei-41_Dmel_ATR -----------------------------------DN-E-S--VKQ-------------- CG2905_Dmel_TRRAP ------------------ARYHGHLLLSHIIARLAIH------KK--IVLQVFHSLLKGH CG6535_Dmel_ATM -----------------------------------EAK-EV--REK-------------- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP TLLEVLLN-FLK-TEQNQGTRREAIRVLGLL----------------------------- DNAPK_Mmus_DNAPK ------------------CYYKMLAVMYSRLLKDDVH------SKEAKINQAFHGSR--- ATR_Mmus_ATR -----------------------------------MQ------PKE-------------- ATM_Mmus_ATM -----------------------------------Y-Q-EV--QEQ-------------- C47D12.1_Cele_TRRAP ------------------MRYTGFFFLANIIERFTIN------RK--IVLQVFHQLMTTY B0261.2_Cele_FRAP SLLDDLLR-ILK-TVMSNTMRREAIKTLGIL----------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR --------------------------------------------------QINYSILR-- TEL1_Scer_ATM -----------------------------------EN-S-S--VSM-------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM -----------------------------------EQV-EV--QKQ-------------- ATR_Hsap_ATR -----------------------------------IQ------PKE-------------- DNAPK_Hsap_DNAPK ------------------GYYKILDVMYSRLPKDDVH------AKESKINQVFHGSC--- TOR_Dmel_FRAP VLIDILIN-FLK-TEQRRSIRRETIRVLGLL----------------------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------CKYSGHLLLAHIIAKFAIH------KK--IVLQVFHSLLKAH smg-1_Cele_SMG1 RLMISSWLHSLI-ATACE----------HQIGSDSFS------QR--EWVRLRNTVIHQS TOR1_Scer_FRAP ELLGILVN-ILK-TENSQNIRRQTVTLIGIL----------------------------- TOR2_Scer_FRAP ELLGILIN-ILK-TENNPHIRRGTVRLIGIL----------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR -----------------------------------SY-P-----EK-------------- DNAPK_Ddis_DNAPK ------------------CCFHLIEALYQSLPSAII---------KEKINPFFYDKP--- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP MLLDTLLN-AIK-TERIGSIRREVIKVLGIL----------------------------- TRRAP_Ddis_TRRAP ELIKFAWN-HLK-NEDLTCKQSAYILACGFIEAYETP------HK--IVLQVYVPLLRAY ATMa_Spur_ATM -----------------------------------NSHDDV--SKQ-------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------CYFELIEVLYSRLSKDDLN------SKDSALNREYRHGN--- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------TKYHGHLLLAHNIAKFAIH------KR--IVLQVFHSLLKAH CC1G_00839_Ccin_ATM ------------------TYHVIHELFASIEDTPLVN------EK--LRL---------- CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP QLLPLLGR-IMR-TETSVQTRREVVKVLGIL----------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ELY--------------------------------------------------------- CC1G_00331_Ccin_TRRAP ------------------IRQMAFLLLARFFSVFPSP------PK--FVLRAWTDLLRLP AqueK043_Aque_ATM -----------------------------------LPEP-K--NKP-------------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------TKYHGHLLLAHIISKFAIH------KR--IVLQVFHSLLKAH ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR -----------------------------------SE-Q-SSTIDA-------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP HLLGLLLR-ILLNGELEWSTRNEVLKVLGVI----------------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP DLFTIVFG-ILK-NDTSQEIRLEAAKLITTI----------------------------- GK009_Glam_PIKK-Unclassified QLI----ELIIDGRRISEET----KRVARLLV---------------------------- TRRAP_Hsap_TRRAP AME-ARAIVR-QAMAILTPAV---P----------------------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP --------------------G--------------------------------------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ALE-ARSIVK-QALDVLTPAM---P----------------------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP --------------------G--------------------------------------- DNAPK_Mmus_DNAPK VAE-GNELT-KTLLKLCHDAF---TENMVGESQLLEK--RRLYHCAAYNCAISLISCVFN ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP QQD-TRDQIR-KAIDILTPAL---R----------------------------------- B0261.2_Cele_FRAP --------------------G--------------------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ITE-GNELT-KTLIKLCYDAF---TENMAGENQLLER--RRLYHCAAYNCAISVICCVFN TOR_Dmel_FRAP --------------------G--------------------------------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP AME-ARAIVR-QAMAILTPAV---P----------------------------------- smg-1_Cele_SMG1 VLTWNNECVN-QALTILSTAT--------------------------------------- TOR1_Scer_FRAP --------------------G--------------------------------------- TOR2_Scer_FRAP --------------------G--------------------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK DGK-GTELT-AAIMKAAHSAK---SEKLTSDDKYVTRSLCTKYHGAAFSALASVIVSTQT SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP --------------------G--------------------------------------- TRRAP_Ddis_TRRAP QPE-SKHLVK-QALDILMPCF--------------------------------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK VEK-GNEMS-TALTKAALGAR---NEDCRGETVAVEL--RRQFHCAAFNCSAAIISCVQD FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP AAE-ARSVVR-QALDILTPVL---P----------------------------------- CC1G_00839_Ccin_ATM ----------------VNALCLWIA----------------------------------- CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP --------------------G--------------------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP HSE-GRASVRYEALSILAPSL---P----------------------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP AIE-ARAIVR-QALDILTPVV---P----------------------------------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP --------------------G--------------------------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP --------------------G--------------------------------------- GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ----------ALD----------------------------------------------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ----------ALD----------------------------------------------- DNAPK_Mmus_DNAPK ELKFYQGFLFNEKPEKNLFIFENLIDLKRCYTFPIEVEVPMERKKKYIEIRKEARDAA-- ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ----------AID----------------------------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ELKFYQGFLFSEKPEKNLLIFENLIDLKRRYNFPVEVEVPMERKKKYIEIRKEAREAA-- TOR_Dmel_FRAP ----------AMD----------------------------------------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ----------KWS----------------------------------------------- TOR1_Scer_FRAP ----------AID----------------------------------------------- TOR2_Scer_FRAP ----------ALD----------------------------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK KENFFHVFFFKENKDKNEYLWENIIDTDQVFNFQPETNFLVSYSTPQ------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ----------SLD----------------------------------------------- TRRAP_Ddis_TRRAP ----------K------------------------------------------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK NIKFYNAFLFSENHAKGQFLLDNLVDPKKEYGFAIEMDAPVERKKRFVAIRTQARETNTP FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ----------ALD----------------------------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ----------ALD----------------------------------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ----------AID----------------------------------------------- GK009_Glam_PIKK-Unclassified ----------S------------------------------------------------- TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK --NGASGS-PHYMSSLSYLTDSSLSEEMSQFDFSTGVQSYSYSSQDRKPTTGHFQRREHQ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK --NGDSDG-PSYMSSLSYLADSTLSEEMSQFDFSTGVQSYSYSSQDPRPATGRFRRREQR TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK --SLF-ANDLRYLS-SQYLVDSSLSQDFIAKNFLEGDNNST--TNNNNGDDGIIMQGQSQ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK EESGYVSGPAHYL-SSQYLSDSSLSEDVNQFDFSSSVRHFGSSMESQRDGGSQGSQGSQR FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK DSM------------TQDD-IMELEMDELNQHECMAPMIALIKHMQRN-VIAPK-----G ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK DPT------------VHDD-VLELEMDELNRHECMAPLTALVKHMHRS-LGPPQ-----G TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK SGDN------------ENQISNDIEIDQVNSNPSMIAMLKIIDFYQKKFVVTPPSSILFG SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK PGSMASRQDSKPVFSPGGE-YLEMEEDALNQHECMAAMTGVLKHMTNN-KINPD-----I FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ----A----------RMEDG--------H------------------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ----PY----------K------------------------------------------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ----L----------RMEDG--------N------------------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ----PY----------K------------------------------------------- DNAPK_Mmus_DNAPK E--------------EGSI---------P------------------------------- ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ----T----------RMEDG--------H------------------------------- B0261.2_Cele_FRAP ----PY----------T------------------------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ----SNIWRILTDISRIENNDILIEKVWN------------------------------- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK E--------------EDSV---------P------------------------------- TOR_Dmel_FRAP ----PY----------K------------------------------------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ----A----------RMEDG--------H------------------------------- smg-1_Cele_SMG1 ----EL----------TSDI---------------------------------------- TOR1_Scer_FRAP ----PY----------R------------------------------------------- TOR2_Scer_FRAP ----PY----------K------------------------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK QQSQQ----------PKPT---------V------------------------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ----PY----------K------------------------------------------- TRRAP_Ddis_TRRAP ----TR----------LPGG--------D------------------------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK T--------------KATK---------A------------------------------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ----Q----------RMEDG--------N------------------------------- CC1G_00839_Ccin_ATM ----Y----------RHQDF--------NDVILLYAVLHGASALLRQEVLARAAQSILQW CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ----PY----------R------------------------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ----K----------SDGD---------D------------------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ----V----------RMEDA--------N------------------------------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ----PH----------V------------------------------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ----PI----------F------------------------------------------- GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP --------------------------Q---MLTHWTR--------KI------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ---------------------------------------VNDLYEFI------------- CG2905_Dmel_TRRAP --------------------------T---MLTHWTK--------KI------------- CG6535_Dmel_ATM ---------------------------------------TMSIVMYI------------- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK --------------------------K---DLPPWMKFLHDKLGN--------------- ATR_Mmus_ATR ---------------------------------------TAAIFHYL------------- ATM_Mmus_ATM ---------------------------------------VLDLLKYL------------- C47D12.1_Cele_TRRAP --------------------------L---QILSHVK--------KI------------- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR --------------------------R---LS----Y--------DM------------- TEL1_Scer_ATM ---------------------------------------RYQYPLHI------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ---------------------------------------VLDLLKYL------------- ATR_Hsap_ATR ---------------------------------------TAAIFHYL------------- DNAPK_Hsap_DNAPK --------------------------R---DLPSWMKFLHGKLGN--------------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP --------------------------Q---MLTHWTR--------KI------------- smg-1_Cele_SMG1 ----------------------------HRDIADKTK--------KA------------- TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ---------------------------------------SLLIFDYL------------- DNAPK_Ddis_DNAPK --------------------------G---DMPKWMFEIYQKLQ---------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP --------------------------PKNSTWVKWTK--------KI------------- ATMa_Spur_ATM ---------------------------------------ALSLVEFL------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK --------------------------E---EMPQWMSGLQKKLSS--------------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP --------------------------A---MLTHWTK--------KI------------- CC1G_00839_Ccin_ATM TFRCYHKFKAADSRLSRILIRLSSICH---DYAAQVH--------DP------------- CC1G_08126_Ccin_ATR --------------------------------------ARKIIVESL------------- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------C--------LPLWCPGTDTAHTNP CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP --------------------------P---EFPQWAKATRRLLTE--------------- AqueK043_Aque_ATM ---------------------------------------AIALLDYI------------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP --------------------------A---TLVHWTK--------KI------------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ---------------------------------------AVQILEEL------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP -----------------IV------------------------------EEGH-T--VP- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR -----------------IL------------------------------RNAS-M--LG- CG2905_Dmel_TRRAP -----------------IV------------------------------EEGH-A--MQ- CG6535_Dmel_ATM -----------------LE------------------------------SKKG-HINLN- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK --------------------------------------------------AS-----VSL ATR_Mmus_ATR -----------------II------------------------------ENRD-A--VQ- ATM_Mmus_ATM -----------------VI------------------------------DNKD-NKNLS- C47D12.1_Cele_TRRAP -----------------LI------------------------------EECH-N--LQ- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -----------------VIDKISTDAMIKRVFWLIPLEVEKRIDLKFEISKSR-Q--IE- TEL1_Scer_ATM -----------------PL------------------------------ALGA-T--LV- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM -----------------VI------------------------------DNKD-NENLY- ATR_Hsap_ATR -----------------II------------------------------ENRD-A--VQ- DNAPK_Hsap_DNAPK --------------------------------------------------PI-----VPL TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP -----------------IV------------------------------EEGH-T--VP- smg-1_Cele_SMG1 -----------------KW------------------------------KEAT-T--IW- TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR -----------------II------------------------------KNRT-I--LK- DNAPK_Ddis_DNAPK --------------------------------------------------QG-----VHP SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP -----------------IV------------------------------EEGH-T--TA- ATMa_Spur_ATM -----------------VV------------------------------ENHG---KLK- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK --------------------------------------------------QS-----TEH FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -----------------IV------------------------------EEGY-T--IA- CC1G_00839_Ccin_ATM -----------------AA------------------------------VRLGED--LL- CC1G_08126_Ccin_ATR -----------------QL------------------------------AFGR-L--KD- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K SHPHHRIVRIPPGESVVL------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP --------------------------------------------------EG-----AG- AqueK043_Aque_ATM ------------------I------------------------------ENGQ-IRALQ- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP -----------------IV------------------------------EEGQ-T--MA- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR -----------------IL------------------------------KNRR-L--LG- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP -QLVHILHLIVQHF---------------------------------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR -TFITDLYFLDRME---NVSPSIQKCIRRHTAHLDLKGLAEEENQSPPLVDQLRFLQKHI CG2905_Dmel_TRRAP -QLFHILQLIIRHY---------------------------------------------- CG6535_Dmel_ATM -SF---LEETTDCEF---LKPLRE-------------DCKSSQPN-ID-RADVANYLRSF CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK NIRLFLAKLVINTE---------------------------------------------- ATR_Mmus_ATR -DFLHEIYFLPDHPELEKIKAVLQ-------------EYRKETSETTDLQTTLQLSMKAI ATM_Mmus_ATM -VTIKLLDPFPDHVIFKDLRLTQQ-------------KIKYSGGP-FSLLEEINHFLSVS C47D12.1_Cele_TRRAP -HVQHVFQMVVRNY---------------------------------------------- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -DVLEFIRMFPQY----------------------------------------------- TEL1_Scer_ATM -QTQFAHEKNNTHEFKLLFLSVITDL-EK------------TSTYIGKLRCARELKYLFV MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM -ITIKLLDPFPDHVVFKDLRITQQ-------------KIKYSRGP-FSLLEEINHFLSVS ATR_Hsap_ATR -DFLHEIYFLPDHPELKKIKAVLQ-------------EYRKETSESTDLQTTLQLSMKAI DNAPK_Hsap_DNAPK NIRLFLAKLVINTE---------------------------------------------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP -QLVHILHLIVQHF---------------------------------------------- smg-1_Cele_SMG1 -ESGDCNTYIRQSM---------------------------------------------- TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR -PYFKTIPFLPKEY--TVLKPYIQ-------------ELES---SSANLTTQIKQLMELF DNAPK_Ddis_DNAPK NIVIFMIKIIINRP---------------------------------------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP -QLVHIIQLIVRHP---------------------------------------------- ATMa_Spur_ATM -EALLDTNPLPDKAELKKARKVLE-------------KIKNKQED-ANLLAEINHFLMRG ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK NIKLFIVRLVINAQ---------------------------------------------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -QLVHMLQLLVRHY---------------------------------------------- CC1G_00839_Ccin_ATM -QWFDAQMVKLSTV---------------------------------------------- CC1G_08126_Ccin_ATR -DLIHYLDDLPDLSIIDDLKPLHF----------HLSQLRH----PLPPRDSLEKLLDRC CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP -QAFAIYHLIVKQP---------------------------------------------- AqueK043_Aque_ATM -DHLILLDPLPGEGPVKEASSRLD-------------IIKASVNE-QSLSREINRFCMVH AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP -QLIHILQLLCRHY---------------------------------------------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR -DQIKELPLLPSLEPLAAVNAVLN-------------EVRG---F-LSLRDQLLRAGEGL DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified -------------------------------------IYRKE------------------ TRRAP_Hsap_TRRAP ----------------KVYYPVRHHLVQHMVS-AMQRLGFTP---------SV-TI---E SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR -TDECLQVRVYALQHLGDLFG---RRRPKLNS---------------------------- CG2905_Dmel_TRRAP ----------------KVYFPVRHQLVQHLIN-YMQRLGFPP---------TA-SI---E CG6535_Dmel_ATM LLS----PTPERLRDLRTYIA---EHKDKV------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ----------------EVFRPYAKHWLSP-----LLQLAVCE---------NN-RE---G ATR_Mmus_ATR -QHENVDVRIHALTSLKETLY---KNQEKLIK---------------------------- ATM_Mmus_ATM AYNPLPLTRLEGLKDLRRQLE---QHKDQMLD---------------------------- C47D12.1_Cele_TRRAP ----------------RVYYHVRLELLTPLLN-GVQRALVMP---------NS-VLENWQ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------PSVQ-------------------------------- TEL1_Scer_ATM -LYENVLVKSSTLN----FII---IRLSKFLI---------------------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM VYDALPLTRLEGLKDLRRQLE---LHKDQMVD---------------------------- ATR_Hsap_ATR -QHENVDVRIHALTSLKETLY---KNQEKLIK---------------------------- DNAPK_Hsap_DNAPK ----------------EVFRPYAKHWLSP-----LLQLAASE---------NNGGE---G TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ----------------KVYYPVRHHLVQHMVS-AMQRLGFTP---------SV-TI---E smg-1_Cele_SMG1 ----------------STVYQMSQERQQKTI----------------------------- TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR -SNESIEVKLMSTNKLKELLS---ANKSIIHE---------------------------- DNAPK_Ddis_DNAPK ----------------QYFERFHELWIPI-----LMDYVVSE---------GNGGN---G SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ----------------QLFYPSRSQFVPHIIL-LLPKIALGS---------NL-TA---E ATMa_Spur_ATM GQH-CKNHTLEGLNSLHHELA---SRKAELAM---------------------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ----------------DVFQPYARFWLSP-----LMQFLAGG---------QQ--G---G FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ----------------KVYYPVRHHLIQTMVY-SIQRLGNTP---------NA-TL---E CC1G_00839_Ccin_ATM ----------------PVLLDVI-CKAMPAWAHR-------PSAALATVQKAV-TVEHL- CC1G_08126_Ccin_ATR -SSSNLTIATLALEELKRFMQ---TGDPALLH---------------------------- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ----------------DLFYPVRSLFVPHMTN-SLNKLGMSP---------SS-TT---E AqueK043_Aque_ATM SGNSIASDSVQGLKSLLHCLK---SFHSEL------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ----------------KVYYPVRQHLVQHMVS-SMQRLGLTS---------NA-TL---E ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR -NHESLSLRLVTATELLKLLS---SKRNDITA---------------------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified -------------------NEMRH------------------------------------ TRRAP_Hsap_TRRAP QRRLAVDLSEVVIKWELQRIKDQQPD-SDMDPNSS-G---EGVNSVS------SSIKRGL SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ---------------HKVNIGMIDQS--RDASAVSLS----------------------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP HKKLAVDLAEVIIKWELHRIKDDRET--KTDGT-E-E---ELIQES--------SVKRSG CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ---------------HKVNIGMIDQS--RDASAVSLS----------------------- DNAPK_Mmus_DNAPK IHYMMVEIVATILSWTGLATPTGVP--KDE------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP TRRHAVEICEMVIKWELFRTLKTDHIISDEEALEV-DKQLDKLRT--------------- B0261.2_Cele_FRAP ---------------HKVFTGSVQS---STAISTALS----------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK IHYMVVEIVATILSWTGLATPTGVP--KDE------------------------------ TOR_Dmel_FRAP ---------------HKMNKGLIDSQ--KDNVLIAYS----------------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP QRRLAVDLSEVVIKWELQRIKDQQPD-SDMDPNSS-G---EGVNSV--------SIKRGL smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ---------------QKEREVT-STT---------------------------------- TOR2_Scer_FRAP ---------------HREIEVT-SNS---------------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK LHYFVRDVCFILLKWPNIYKSQDGG--GGT------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ---------------HKMNELG-KRR--E------------------------------- TRRAP_Ddis_TRRAP NKKLSIDIADTIIIWEKMRMSNLQQS--IKTSSSSLP----------------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK INYMVLDIMLVMLDWSTLAVPEDDE--ERS------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP HRKLVVELVEVIIKWEVQRIREDEGT--A-EPATP-V---EEPPVVAAAPAAPAGVKRSA CC1G_00839_Ccin_ATM -------------------------------------SAIL------------------- CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ---------------RKSRPDE-DVA--------SNA----------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP SRHLSLDILQTVFNWEEQAARQAQD--AGE-NKGG-I----------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP QRRLAVDLTEVIIKWEFQRAKEAQEM--DGEPMEI-M---KDTASTA--VTSGLGLKRSG ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ---------------NKRNELRLHP---SDGNRSSLS----------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ---------------YQNGKPDL--S--ALVPPTNLT---CKCQSTDVFSLDYIMDESNI GK009_Glam_PIKK-Unclassified ----------------TQLYSSVDSQ---------------------------------- TRRAP_Hsap_TRRAP SVDSAQEVKR----------------------------------------FRT-ATGAIS SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------ESKSSQDSSDYSTSEMLV--------------------NMG-NL---------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP -IDLVE------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------ESKSSQDSSDYSTSEMLV--------------------NMG-NL---------- DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------ASSTDR B0261.2_Cele_FRAP ------LPISETDSKDPRQDIIHW--------------------FNYEKC---------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------DGKVD-ESQDIS--TAEL--------------------LVNMGN---------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP SVDSAQEVKR----------------------------------------FRA-ATGAIS smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------D--ISTEQNAPPIDIALL--------------------MQGMSP---------- TOR2_Scer_FRAP ------K--SSVEQNAPSIDIALL--------------------MQGVSP---------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------DPKANDDKNNNMTNEV-I--------------------TI--SP---------- TRRAP_Ddis_TRRAP ------TTTTTTTSSNKPTDSSSL---------------------PP--NTPI-AEGSIT ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP STDLLPDPKR----------------------------------------VRH-TSSGST CC1G_00839_Ccin_ATM -----------------------------------------------------------R CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------ETSVA-AVNQV----PIN--------------------PHPTSS---------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP SDGTA----------------------------------------------GSGNGGGGG ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------ETVHG-QTNDESLMEAWP--------------------TGGISA---------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP WVCHKGEGGAAQEASIKSHGKAVVSPITGHVVENVYIMKLDSGSEVSANV---------- GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP AVFGRSQS---LPGAD-------------------------------------------- SMG1_Hsap_SMG1 -----------------------PQDFSDVISFILY-GNS------------------HR FRAP_Hsap_FRAP -------------PLDEFYP---------------------------------------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ---TRKK----------------------------------------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 -----------------------PGMASRRVSVWQQ-RISQYSAVRDNVFRDFFDR-VQK FRAP_Mmus_FRAP -------------PLDEFYP---------------------------------------- DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP FDFEEAHNKRDMP----------------------------------------------- B0261.2_Cele_FRAP -------------TLEEFYP---------------------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -------------FAD-------------------------------------------- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP -------------ALDEYYP---------------------------------------- SMG1_Mmus_SMG1 -----------------------PQDFSDVISFILY-GNS------------------HR TRRAP_Mmus_TRRAP AVFGRSQS---LPGAD-------------------------------------------- smg-1_Cele_SMG1 -----------------TSTSFGAEEFIIITNFLLKQA----------------TPTTFK TOR1_Scer_FRAP -------------SNDEYYT---------------------------------------- TOR2_Scer_FRAP -------------SNDEYYP---------------------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 -----------------------GQIFKKIFDWIMG-IGK------------------DQ Tor_Ddis_FRAP -------------SNEDYYP---------------------------------------- TRRAP_Ddis_TRRAP TPSQGGVA---TPNVSDSTPTPG------------------------------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP V----------RS-IT-------------------------------------------- CC1G_00839_Ccin_ATM DGHISSNKFRVVR----------------------------------------------- CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP -------------SSDDYFQ---------------------------------------- CC1G_06302_Ccin_PI3K ----------------------------PSAP---Q-ISATFVNDPSL--WGVVDP---- CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K -----------------ETY---------------------------------------- CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP AELKRQRS---QA-QV-------------------------------------------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -------------ATEDYYS---------------------------------------- SMG1_Smoe_SMG1 -----------------------PPQVVCILN---Y-ISQRPQSLPAGWQQRLVFN---- GK008_Glam_FRAP -------------SDFELTL---------------------------------------- GK009_Glam_PIKK-Unclassified --------------LHDVDDP--------------------------------------- TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 TGKDNW----LERLF-YS-----------------------------------CQR---- FRAP_Hsap_FRAP -----------------A--VSMVALMRIFRDQSLSHHH------------------TM- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 PEQDSLIHC-LRELFVRS-----------------------------------CQV---- FRAP_Mmus_FRAP -----------------A--VSMVALMRIFRDQSLSHHH------------------TM- DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP -----------------A--ITIANLMLMMQDEDS-QSY------------------AE- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP -----------------A--VAIAALMRILRDPTLSTRH------------------TS- SMG1_Mmus_SMG1 TGKDNW----LERLF-YS-----------------------------------CQR---- TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 KGQNSWMDEVLET-FTQG-----------------------------------CRT---- TOR1_Scer_FRAP -----------------T--VVIHCLLKILKDPSLSSYH------------------TA- TOR2_Scer_FRAP -----------------T--VVIHNLMKILNDPSLSIHH------------------TA- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 PSFDSLTKY-LIDLF-DS--FNVISILFNEQNK-ILSQQYLAAQSTMITPPLSLHQ---- Tor_Ddis_FRAP -----------------T--VALTALMKILRDPSLSSHH------------------TS- TRRAP_Ddis_TRRAP ----------------IH-----------------------------------HGA---- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP -----------------T--VVITSLLAILKDQSLSSHH------------------HT- CC1G_06302_Ccin_PI3K -----------------------------------------------------DITNENP CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ----------------------LIELLTLFGDKGVAIQH------------------SKA CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -----------------TVKVAINALMRTLRDPSSSIYH------------------QS- SMG1_Smoe_SMG1 -----------------------------------------------------CLKTKSA GK008_Glam_FRAP -----------------N--VIMSTLYSILSESTLDMYH------------------YD- GK009_Glam_PIKK-Unclassified --------------------AAVLALLELLVDAS-------------------------- TRRAP_Hsap_TRRAP -------------S----LLAK--PID-KQ---HTDTVVNFLIRVACQ-VND-NT---N- SMG1_Hsap_SMG1 --------LDKRDQ-STI-----------PRNLLKTDAVLWQ-WAIWEAAQF--TVLSKL FRAP_Hsap_FRAP -------------------------------------VVQAITFIF-----------KSL mei-41_Dmel_ATR ---------------------T--ILS-EL---PLEPMLEQIVNVLMAGC-Q-HD----- CG2905_Dmel_TRRAP --------------------------------------SFDIIR---------------- CG6535_Dmel_ATM -----------------------------Q---EHEKLLFGVINKLIQMT-RD-AHN--- CG4549_Dmel_SMG1 --------APQDERQMNL-----------SQCTKRCQRLAIA-WLQFEAARY--CVDQRL FRAP_Mmus_FRAP -------------------------------------VVQAITFIF-----------KSL DNAPK_Mmus_DNAPK -----------------------------VL---ANRLLRFLMKH-----VF-HP---K- ATR_Mmus_ATR ---------------------Y--ATD-SE---TVEPVISQLVTVILKGC-Q-DA----- ATM_Mmus_ATM ---------------------LLRASQ-DN---PQDGIVVKLVVSLLQLS-KM-AVNQT- C47D12.1_Cele_TRRAP ------------------DAQR--TII-KE---HADVIVNMLVRFCMT-FHQ-NS----- B0261.2_Cele_FRAP -------------------------------------IAQAIVTIF-----------RSL atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -------------NLASKIERK--TVY-KE---ELPKLIGSLSRILPQ-CHS-KR---E- TEL1_Scer_ATM ---------------------D--TQI-HD---EVITIFSSLLNL----A-D-KN----- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ---------------------IMRASQ-DN---PQDGIMVKLVVNLLQLS-KM-AINHT- ATR_Hsap_ATR ---------------------Y--ATD-SE---TVEPIISQLVTVLLKGC-Q-DA----- DNAPK_Hsap_DNAPK -----------------------------VL---ANRLLNFLMKH-----VF-HP---K- TOR_Dmel_FRAP -------------------------------------VVQAVTFIF-----------QSL SMG1_Mmus_SMG1 --------LDKRDQ-STI-----------PRNLLKTDAVLWQ-WAIWEAAQF--TVLSKL TRRAP_Mmus_TRRAP -------------S----LLAK--PID-KQ---HTDTVVNFLIRVACQ-VND-NT---N- smg-1_Cele_SMG1 --------LEKPDSY--V---------------PETFIEKWD-WIINQTANF--CIVNKM TOR1_Scer_FRAP -------------------------------------VIQAIMHIF-----------QTL TOR2_Scer_FRAP -------------------------------------AIQAIMHIF-----------QNL TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ---------------------M---IQ-LD---SDPILINDLVKSLLIGC-R-DP----- DNAPK_Ddis_DNAPK -----------------------------TLEKHLSKFVNHLMKN-----TY-CT---D- SMG1_Ddis_SMG1 --------I--DDR-RKF-----------ETLISKSDELIWF-WTVWECSKF--CIANRL Tor_Ddis_FRAP -------------------------------------VIQAVMYIF-----------KSL TRRAP_Ddis_TRRAP --------TNIDDE-------------------YRPPLSAIE-HISLFLIRM-ASNWYHI ATMa_Spur_ATM ---------------------LVSMCA-ES---ASDSVLPQLICELVSLC-GSNHSNQD- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK -----------------------------PL---VAQD---------------------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -------------S----EASK--PIE-KV---YSDAVVNFLIRLACQ-VND-SS---S- CC1G_00839_Ccin_ATM ------------------RLAE--EPF-HN---EIQFPSKAFWRLKES-LPP-TD----- CC1G_08126_Ccin_ATR ---------------------E--LLE-DD---MFDPMIGRLISTVYSAAAR-DG---D- CC1G_00894_Ccin_FRAP -------------------------------------VIEAIMSIF-----------KTQ CC1G_06302_Ccin_PI3K V-----------------EDKH--RRLVRSHRSSPYDRELKPNAKIRDELTH--ILNYSP CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K QNMELKIDDMVEQLASLLLPVD--ALLTHADFNPHEDASKEIVTLF-----------RNT CC1G_00331_Ccin_TRRAP -------------------WRT--PL---S---LRENMVSYLMRLATI-AHD-QP---T- AqueK043_Aque_ATM ----------------------QI--N-NP---DTSNLILELIHTLLNTA-RH-SPD--- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP -------------A----DPTW--PLD-KQ---HADSIINFLIRLACQ-VND-TQ---VP ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ---------------------L--VLRETP---ADADAVSSLVTRLLRGC-S-EESRTS- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -------------------------------------VVKSLMYIC-------------- SMG1_Smoe_SMG1 DDKKQGDGLDRKED-FSVVEDA--ARFDLVESWCCSSNMAAAWFIIQELARH--CITVRF GK008_Glam_FRAP -------------------------------------AVVVFRTII-----------QTE GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ---TAG-S---------------------------------------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP -GLK-------------------------------------------------------- mei-41_Dmel_ATR -----D-S---------------------------------------------------- CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM -------K---------------------------------------------------- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP -GLK-------------------------------------------------------- DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR -----N-S---------------------------------------------------- ATM_Mmus_ATM ----GER----------------------------------------------------- C47D12.1_Cele_TRRAP --GSSS-T---------------------------------------------------- B0261.2_Cele_FRAP -GDM-------------------------------------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -Q---------------------------------------------------------- TEL1_Scer_ATM -----T-FEIEPSLPNLFCKIFIYLRENKQLSPSFQQAIKLLEHRDLIKIKTWKYFLDAI MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ----GEK----------------------------------------------------- ATR_Hsap_ATR -----N-S---------------------------------------------------- DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP -GIK-------------------------------------------------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ---TAG-S---------------------------------------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP -GLK-------------------------------------------------------- TOR2_Scer_FRAP -GLR-------------------------------------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR -----Y-L---------------------------------------------------- DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP -SLK-------------------------------------------------------- TRRAP_Ddis_TRRAP -NEK-------------------------------------------------------- ATMa_Spur_ATM ----GQAS---------------------------------------------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -TTTVS-S---------------------------------------------------- CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ----LT-E---------------------------------------------------- CC1G_00894_Ccin_FRAP -GLK-------------------------------------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K W-FL-------------------------------------------------------- CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM -------S---------------------------------------------------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP GNATSP-N---------------------------------------------------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ----AG-Q---------------------------------------------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP CTAI-------------------------------------------------------- GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP --------------------------------------PGEVLSRRCVNL---------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ----------------------------------------------CVQF---------- mei-41_Dmel_ATR --------------------------------------QLQMASAKCLGE---------- CG2905_Dmel_TRRAP ---------------------------------------ETTVQGKCVML---------- CG6535_Dmel_ATM --------------------------------------TTSIDSLKCLAQ---------- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ----------------------------------------------CVQF---------- DNAPK_Mmus_DNAPK ----------------------------------------RAVFRHNLEI---------- ATR_Mmus_ATR --------------------------------------QARLLCGECLGE---------- ATM_Mmus_ATM --------------------------------------EVLEAVGRCLGE---------- C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ----------------------------------------------APLY---------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -----------------------------------------NKIIKILQK---------- TEL1_Scer_ATM FGNIVQDDIYENTELLDASDCGVDDVVLVSLLFSYARRPVASKIGCSLSK---------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM --------------------------------------EVLEAVGSCLGE---------- ATR_Hsap_ATR --------------------------------------QARLLCGECLGE---------- DNAPK_Hsap_DNAPK ----------------------------------------RAVFRHNLEI---------- TOR_Dmel_FRAP ----------------------------------------------CVPY---------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP --------------------------------------PGEVLSRRCVNL---------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ----------------------------------------------CVSF---------- TOR2_Scer_FRAP ----------------------------------------------CVSF---------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR --------------------------------------KLSVNFLTCLGE---------- DNAPK_Ddis_DNAPK ----------------------------------------RRILKSNLNI---------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ----------------------------------------------SIPF---------- TRRAP_Ddis_TRRAP ----------------------------------------------CSEL---------- ATMa_Spur_ATM --------------------------------------ALQKAAGQCLGE---------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------IAMTRSSI---------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP --------------------------------------PGEQLSRRCMAL---------- CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR --------------------------------------SLRLVAYECIGI---------- CC1G_00894_Ccin_FRAP ----------------------------------------------CVTF---------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ----------------------------------------------CVLFDFTHMDNQES CC1G_00331_Ccin_TRRAP --------------------------------------R-GIYVSRALGL---------- AqueK043_Aque_ATM --------------------------------------SC--HVSQCLGE---------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP --------------------------------------PAEQLSKRCVSL---------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR --------------------------------------KFKLACAECLGG---------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ----------------------------------------------SLPM---------- GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP --LKTALRPDMWPK-S--ELKLQWFDKLLMTVEQPNQ----------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP --LPQ--------------------------------VMPTFLNVIRVC-----DGAIRE mei-41_Dmel_ATR --LG-AIDASYLP---------------SNYNFAS------------------------- CG2905_Dmel_TRRAP --LKMAMRPEIWPQPF--DIKLNWLDKVLATVETPH------------------------ CG6535_Dmel_ATM --IG-PLKISTVS---------------YYFQTD-------------------------- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP --LPQ--------------------------------VMPTFLNVIRVC-----DGAIRE DNAPK_Mmus_DNAPK --IKTLV--ECWKE-CL-SIP--------------------------------------- ATR_Mmus_ATR --LG-AIDPGRLD---------------FSTTETQ------------------------- ATM_Mmus_ATM --IG-PLDFSTIA---------------VQHNK--------------------------- C47D12.1_Cele_TRRAP ---SQTLRPSMWGEFV--SFRLTMIEKFLSI-PNDNA----------------------- B0261.2_Cele_FRAP --TEQ--------------------------------VIPRLIEVCRRATESSNRANLRE atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR --LPIICSDLPDHNFIRWDTRFKF-------FCEPRQ----------------------- TEL1_Scer_ATM --AA-AINILK------------------------------------------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM --VG-PIDFSTIA---------------IQHSK--------------------------- ATR_Hsap_ATR --LG-AIDPGRLD---------------FSTTETQ------------------------- DNAPK_Hsap_DNAPK --IKTLV--ECWKD-CL-SIP--------------------------------------- TOR_Dmel_FRAP --LAQ--------------------------------VLPNLLDNVRTA-----DNNLRE SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP --LKTALRPDMWCK-S--ELKLQWFDKLLMTVEQPNQ----------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP --LDQ--------------------------------IIPTILDVMRTC-----SQSLLE TOR2_Scer_FRAP --LDQ--------------------------------IIPGIILVMRSC-----PPSQLD TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR --LG-AIDPVKLD---------------FSLRNQS------------------------- DNAPK_Ddis_DNAPK --VKSFV--ERWKS-LF-KVD--------------------------------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP --LPQ--------------------------------IMPPFLHAMNTG-----EPLFRE TRRAP_Ddis_TRRAP --LRQTL--VIWPE-T--NIKFSVFEKPMNT-DQPQ-M---------------------- ATMa_Spur_ATM --IG-SPDLSVIA---------------LKKWGGG------------------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK --TKTTS----QRK-AK-HPP--------------------------------------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP --LKTALRPDVWPN-S--ELRLNFLDKLFLSVGK-------------------------- CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR --LG-ALDPYRFQ---------------LPARRAD------------------------- CC1G_00894_Ccin_FRAP --LPQ--------------------------------IIPAFAAITRTS-----IARLQE CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K TALDW--------------------------------LRPALARIALKT-----PSMVV- CC1G_00331_Ccin_TRRAP --LQNIVGPSGWTD-V--TVGLRFFSRALEQTELS------------------------- AqueK043_Aque_ATM --IG-CIELQSIS---------------AHVVTNG------------------------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP --IRTALKPDLWPS-I--DVKLSWFGKLLETISQVDPS---------------------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR --LG-AIDPVKLQ---------------ISLRHRS------------------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ----K--------------------------------VMPDLLLTIRNC-----EDNLRE SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP --VPK--------------------------------IISLILENIQNC-----KVFMQE GK009_Glam_PIKK-Unclassified -------------------------------------------------------HTPCE TRRAP_Hsap_TRRAP ------------------------VN-----------YGNI---C-------TGLEVLSF SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP FLFQQLGMLVSFVKSHIRP---------------------------------YMDEIVTL mei-41_Dmel_ATR -----------------------PQ------------H--L---P-------LNILSDDF CG2905_Dmel_TRRAP ------------------------HN-----------LNNI---C-------TGIDFLTF CG6535_Dmel_ATM -------------------------------------FEAF---EKSNG-----E-PMEA CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP FLFQQLGMLVSFVKSHIRP---------------------------------YMDEIVTL DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR -----------------------GK------------DFTF---V-------TGVEDLSF ATM_Mmus_ATM -------------------------------------DVSY---TKAYGLPED--RELQ- C47D12.1_Cele_TRRAP ------------------------LRNDISSTAYANTIQNA---Q-------HTLDMLCN B0261.2_Cele_FRAP FFLQQLANFVAIIRKHAAP---------------------------------YMPAIFTI atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------LT-----------QAVLEDCA--------------- TEL1_Scer_ATM --------------------------------------HHV---P-------KEYLSKNF MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM -------------------------------------DASY---TKALKLFED--KELQ- ATR_Hsap_ATR -----------------------GK------------DFTF---V-------TGVEDSSF DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP FLFQQLAILVAFVKLHIIS---------------------------------YMGDIFKL SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------VN-----------YGNI---C-------TGLEVLNF smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP FYFQQLCSLIIIVRQHIRP---------------------------------HVDSIFQA TOR2_Scer_FRAP FYFQQLGSLISIVKQHIRP---------------------------------HVEKIYGV TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR -----------------------TA------------E--K---D-----------KVQI DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP FLFQQLGSLVSIVKQHIRD---------------------------------YLVNVFAL TRRAP_Ddis_TRRAP -----------------IS---------------------------------TCLSMLNL ATMa_Spur_ATM -----------------------EQ------------SASY---STAVKRFSDNNDRISC ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR -----------------------TIV-----------LRNF---T-------DENETYQF CC1G_00894_Ccin_FRAP FHLQQLAILVGIIKQHIRN---------------------------------YTLDVFSL CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP -----------------------DAT-----------LLQA---L-------SAAKVLHV AqueK043_Aque_ATM -----------------------GTR-----------GRGP---GGG-YVFKQERDKIV- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------NAAASNST-----------YVNV---C-------TALEILLF ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR -----------------------SM------------Q--H---T-----------EEDL DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP FIFCQLADLVAIVRQHIRK---------------------------------YLSSILSL SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP TMLRELILIISSIGHHAHS---------------------------------YVSDIFDI GK009_Glam_PIKK-Unclassified FLWRV------------------------------------------------------- TRRAP_Hsap_TRRAP LLTVLQ----SPAILSSFKPLQRGIAACMT--CGNTKVLRAVHSLLSRLMSIF---P--- SMG1_Hsap_SMG1 -------------------------RTPLG--RAQDT----------------------- FRAP_Hsap_FRAP MREFWVM---NTSIQSTIILLIEQIVVALG--GE---FKLYLPQLIPHMLRVF---M--- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP LTTILS----PDQLVSIIRPVQRGLSLCII--HQNTRIVRLMHMFLTRIMAIF---P--- CG6535_Dmel_ATM F----------------------------------------------------------- CG4549_Dmel_SMG1 -------------------------RTTVG--KPQET----------------------- FRAP_Mmus_FRAP MREFWVM---NTSIQSTIILLIEQIVVALG--GE---FKLYLPQLIPHMLRVF---M--- DNAPK_Mmus_DNAPK ----------------YRLIFEKFSHKDP------------------------------- ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM W----------------------------------------------------------- C47D12.1_Cele_TRRAP IIPVMP----KTSLMTMMRQLQRPLIQCLNNGAQNFKMTRLVTQIVSRLL---------- B0261.2_Cele_FRAP IADAWKE---DISVKMVVIEVLTDMGTAIG--ND---FSKYTGELIPYLLTVL---Q--- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -----------------------GIVEVMT--G-TSK-IEYVDRTMCEIYKFF---N--- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR -------------------------------------SNRYLRLLSTRIIPLF---N--- ATM_Hsap_ATM W----------------------------------------------------------- ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ----------------YRLIFEKFSGKDP------------------------------- TOR_Dmel_FRAP IKEFWTI---NTPLQNTLINLIEQIAVALG--CE---FRDYLAELIPQILRVL---Q--- SMG1_Mmus_SMG1 -------------------------RTPLG--RAQDT----------------------- TRRAP_Mmus_TRRAP LLTVLQ----SPAILSSFKPLQRGIAACMT--CGNTKVLRAVHSLLSRLMSIF---P--- smg-1_Cele_SMG1 -------------------------KTPLG--KPMQT----------------------- TOR1_Scer_FRAP IKDFSS----VAKLQITLVSVIEAISKALE--GE---FKRLVPLTLTLFLVIL---E--- TOR2_Scer_FRAP IREFFP----IIKLQITIISVIESISKALE--GE---FKRFVPETLTFFLDIL---E--- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ----------------KSIILELLSTKGD------------------------------- SMG1_Ddis_SMG1 -------------------------KSPYG--SAFQT----------------------- Tor_Ddis_FRAP IEKYWNS-----NLLIPIIKLVEEISSALN--DE---FKVYLPNLIPQMLNVL---H--- TRRAP_Ddis_TRRAP IAEYQV----NTFIPNNVVALQQSLLQALN--SDNAKISSLLGSLFKKILAAF---P--- ATMa_Spur_ATM R----------------------------------------------------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ----------------AGVIYESLQDRSP------------------------------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -----------PPILSGSKPLQGGIAACMT--CPSTKVIRSVHALLVKLMSTF---P--- CC1G_00839_Ccin_ATM -----------------------KIQ--VEDIAAFTDLLIAHHG---QIDSLN---P--- CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ITELWD----NVTLQLPIVALIEALGKALD--AE---FKPFLPTILPLVLKVF---D--- CC1G_06302_Ccin_PI3K -------------------------SQ--------------------------------- CC1G_04234_Ccin_PI4K ----------NSAERAPYL----------------------------------------- CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP VSKEQP----DSWYLSNAVLLEKLVQKGLL--YDDANLQDALYPIFDKLVTLF---P--- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP LINVLP----PNVLLSGFKSLNRGLHFCMT--SNNTKVVRYLHSFLSRLIKMF---T--- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP VLDMILPTSPRSASHSPILHLVERLCVALH--DE---FRMHMPEILPKCIQAL---N--- SMG1_Smoe_SMG1 -------------------------RTHLG--GPTQT----------------------- GK008_Glam_FRAP IEVLWA----NQQLIELILALLEEVSIVLD--LS---LGNYGSQFFLKFVGLFTVLK--- GK009_Glam_PIKK-Unclassified --------------------------------------------LIPLVIHVL---NGLF TRRAP_Hsap_TRRAP -------------------------------------------TEPS-----TSSVA--- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP -------------------------------------------H---------------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP -------------------------------------------PDTQ------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP -------------------------------------------H---------------- DNAPK_Mmus_DNAPK --------------------------------------------------------N--- ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP --------------------------------------------EK------TNVSV--- B0261.2_Cele_FRAP -------------------------------------------T---------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -------------------------------------------PNEA-----SPEMK--- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR -------------------------------------------ISDSHNSEDEH------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK --------------------------------------------------------N--- TOR_Dmel_FRAP -------------------------------------------H---------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP -------------------------------------------TEPS-----TSSVA--- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP -------------------------------------------N---------------- TOR2_Scer_FRAP -------------------------------------------N---------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK -------------------------------------------------------FK--- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP -------------------------------------------T---------------- TRRAP_Ddis_TRRAP -------------------------------------------LPTN-----NTTTTTPV ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK --------------------------------------------------------D--- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -------------------------------------------TESS-----TSNVA--- CC1G_00839_Ccin_ATM -------------------------------------------EKPS-----LSTIR--- CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP -------------------------------------------G---------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP -------------------------------------------LPEA-----AP-S---- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP -------------------------------------------SELV-----S---G--- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -------------------------------------------E---------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP -------------------------------------------S---------------- GK009_Glam_PIKK-Unclassified VRSYLSLLITLLPHGANLFDQRGMLQIRGGGTPLAHLLLYIKAY---------------- TRRAP_Hsap_TRRAP -------------------------SKYEEL-------------ECLY-----AAVGKVI SMG1_Hsap_SMG1 ----------------------------------------------FQTIEGIIRSLAAH FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP -------------------------HKHEDL-------------DLLY-----TAVSKMI CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ----------------------------------------------FLGFEAIIMRHARL FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK -------------------------S---K-----------------DNSVGIQLLGIVI ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP -------------------------NGLDEL-------------EQLN-----QYISRFL B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -------------------------STLDGI-------------KNMY-----A------ TEL1_Scer_ATM